Finn Olav Levy

• Andresen, Henriette; Pérez-Ternero, Cristina; Robinson, Jerid; Dickey, Deborah M.; Hobbs, Adrian J. & Potter, Lincoln R. [Show all 9 contributors for this article] (2023). Novel enhancers of guanylyl cyclase-A activity acting via allosteric modulation. British Journal of Pharmacology. ISSN 0007-1188. doi: 10.1111/bph.16203. Full text in Research Archive
• Levy, Finn Olav & Osnes, Jan-Bjørn (2023). Can acetate via FFA receptors contribute to the diabetogenic effect of statins? Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 0, p. 1–4. doi: 10.1007/s00210-023-02647-7. Full text in Research Archive
• Manfra, Ornella; Calamera, Gaia; Froese, Alexander; Arunthavarajah, Dulasi; Surdo, Nicoletta C. & Meier, Silja [Show all 14 contributors for this article] (2022). CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors. Cardiovascular Research (CVR). ISSN 0008-6363. 118(6), p. 1506–1519. doi: 10.1093/cvr/cvab167. Full text in Research Archive
• Calamera, Gaia; Moltzau, Lise Roman; Levy, Finn Olav & Andressen, Kjetil Wessel (2022). Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts. International Journal of Molecular Sciences. ISSN 1661-6596. 23:2145(4), p. 1–24. doi: 10.3390/ijms23042145. Full text in Research Archive
• Danielsen, Tore Kristian; Sadredini, Mani; Manotheepan, Ravinea; Aronsen, Jan Magnus; Frisk, Michael & Hansen Haugsten, Marie [Show all 13 contributors for this article] (2021). Exercise training stabilizes RyR2-dependent Ca2+ release in post-infarction heart failure. Frontiers in Cardiovascular Medicine. ISSN 2297-055X. 7. doi: 10.3389/fcvm.2020.623922. Full text in Research Archive
• Barnes, Nicholas M.; Ahern, Gerard P.; Becamel, Carine; Bockaert, Joël; Camilleri, Michael & Chaumont-Dubel, Severine [Show all 39 contributors for this article] (2021). International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacological Reviews. ISSN 0031-6997. 73(1), p. 310–520. doi: 10.1124/PR.118.015552.
• Jang, Wonjo; Adams, C. Elizabeth; Liu, Heng; Zhang, Cheng; Levy, Finn Olav & Andressen, Kjetil Wessel [Show all 7 contributors for this article] (2020). An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 117(48), p. 30755–30762. doi: 10.1073/pnas.2010801117. Full text in Research Archive
• Calamera, Gaia; Li, Dan; Ulsund, Andrea Hembre; Kim, Jeong Joo; Neely, Oliver C. & Moltzau, Lise Roman [Show all 11 contributors for this article] (2019). FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons. Communications Biology. ISSN 2399-3642. 2:394, p. 1–12. doi: 10.1038/s42003-019-0641-x. Full text in Research Archive
• Melsom, Elin Maria Caroline Bull; Cosson, Marie-Victoire; Ørstavik, Øivind; Lai, Ngai Chin; Hammond, H. Kirk & Osnes, Jan-Bjørn [Show all 10 contributors for this article] (2019). Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6. PLOS ONE. ISSN 1932-6203. 14:e021810(6), p. 1–19. doi: 10.1371/journal.pone.0218110. Full text in Research Archive
• Ndongson, Bernadin Dongmo; Lang, Guang-Ping; Mece, Odeta; Hechaichi, Nadine; Lajqi, Trim & Hoyer, Dirk [Show all 12 contributors for this article] (2019). Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice. Basic Research in Cardiology. ISSN 0300-8428. 114:26(3), p. 1–20. doi: 10.1007/s00395-019-0734-1.
• Cosson, Marie-Victoire; Hiis, Halvard Gautefall; Moltzau, Lise Roman; Levy, Finn Olav & Krobert, Kurt Allen (2019). Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the ? <sub>1</sub> -adrenoceptor-mediated inotropic response . Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 131, p. 132–145. doi: 10.1016/j.yjmcc.2019.04.017.
• Ulsund, Amanda Hembre; Dahl, Marie; Frimurer, Thomas; Manfra, Ornella; Schwartz, Thue W. & Levy, Finn Olav [Show all 7 contributors for this article] (2018). Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase. The FASEB Journal. ISSN 0892-6638. 33(3), p. 3870–3886. doi: 10.1096/fj.201800805RR.
• Hiis, Halvard Gautefall; Cosson, Marie-Victoire; Dahl, Christen Peder; Fiane, Arnt E; Levy, Finn Olav & Andersen, Geir Øystein [Show all 7 contributors for this article] (2018). Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 315(5), p. H1137–H1147. doi: 10.1152/ajpheart.00208.2018. Full text in Research Archive
• Andressen, Kjetil Wessel; Ulsund, Andrea Hembre; Krobert, Kurt Allen; Lohse, Martin J.; Bünemann, Moritz & Levy, Finn Olav (2017). Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation. The FASEB Journal. ISSN 0892-6638. 32(2), p. 1059–1069. doi: 10.1096/fj.201700486R.
• Moltzau, Lise Roman; Meier, Silja; Andressen, Kjetil Wessel & Levy, Finn Olav (2017). Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy. In Nikolaev, Viacheslav & Zaccolo, Manuela (Ed.), Microdomains in the Cardiovascular System.. Springer. ISSN 978-3-319-54578-3. p. 245–271. doi: 10.1007/978-3-319-54579-0_12.
• Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina & Skomedal, Tor [Show all 10 contributors for this article] (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology. ISSN 0014-2999. 812, p. 174–183. doi: 10.1016/j.ejphar.2017.07.014.
• Ahamed, Muneer; Vermeulen, Koen; Schnekenburger, Michael; Moltzau, Lise Roman; Levy, Finn Olav & Marton, Janos [Show all 10 contributors for this article] (2017). Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers. Letters in Drug Design & Discovery. ISSN 1570-1808. 14(7), p. 787–797. doi: 10.2174/1570180813666161101152943. Show summary

  Histone deacetylases (HDACs) emerged as important epigenetic regulators of gene expression. In order to identify potential positron emission tomography (PET) tracers for imaging HDACs, we evaluated in vitro and in cellulo activities of some compounds that were reported as potent HDAC2-selective inhibitors. We observed marked differences between reported activity values and the values obtained in our assays for some of the compounds. To understand the structural basis of the activity of some of these inhibitors, we also performed molecular docking studies to understand their interaction patterns and binding modes with HDAC2. We observed the low affinity compounds 4, 6 and 7 did not showed equal number of key π-π interactions and hydrogen bonding when compared to high affinity compounds, and could be the possible reason for poor inhibition as reflected in in vitro assays. These preliminary experimental and computational results will help to interpret the HDAC affinity values of these key compounds with caution.

• Villar, Inmaculada C; Bubb, Kristen J; Moyes, Amie J; Steiness, Eva; Gulbrandsen, Trygve & Levy, Finn Olav [Show all 7 contributors for this article] (2016). Functional pharmacological characterization of SER100 in cardiovascular health and disease. British Journal of Pharmacology. ISSN 0007-1188. 173(23), p. 3386–3401. doi: 10.1111/bph.13634.
• Eikemo, Hilde; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2016). CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 477(1), p. 14–19. doi: 10.1016/j.bbrc.2016.05.138.
• Olberg, Dag Erlend; Bauer, Nadine; Andressen, Kjetil Wessel; Hjornevik, Trine; Cumming, Paul & Levy, Finn Olav [Show all 9 contributors for this article] (2016). Brain penetrant small molecule 18F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats. Nuclear Medicine and Biology. ISSN 0969-8051. 43(8), p. 478–489. doi: 10.1016/j.nucmedbio.2016.05.003.
• Eikemo, Hilde; Moltzau, Lise Roman; Hussain, Rizwan; Nguyen, Hong Cam Thi; Qvigstad, Eirik & Skomedal, Tor [Show all 8 contributors for this article] (2016). CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 471(1), p. 219–225. doi: 10.1016/j.bbrc.2016.01.132.
• Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre; Katz, Betina; Kellmann, Ralf & Gauthier-Landry, louis [Show all 18 contributors for this article] (2016). Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism . OncoTarget. ISSN 1949-2553. 7(2), p. 1878–1894. doi: 10.18632/oncotarget.6479. Full text in Research Archive Show summary

  The underlying mechanisms responsible for the development of castration-resistant prostate cancer (CRPC) in patients who have undergone androgen deprivation therapy are not fully understood. This is the first study to address whether β2-adrenergic receptor (ADRB2)- mediated signaling may affect CRPC progression in vivo. By immunohistochemical analyses, we observed that low levels of ADRB2 is associated with a more rapid development of CRPC in a Norwegian patient cohort. To elucidate mechanisms by which ADRB2 may affect CRPC development, we stably transfected LNCaP cells with shRNAs to mimic low and high expression of ADRB2. Two UDP-glucuronosyltransferases, UGT2B15 and UGT2B17, involved in phase II metabolism of androgens, were strongly downregulated in two LNCaP shADRB2 cell lines. The low-ADRB2 LNCaP cell lines displayed lowered glucuronidation activities towards androgens than high-ADRB2 cells. Furthermore, increased levels of testosterone and enhanced androgen responsiveness were observed in LNCaP cells expressing low level of ADRB2. Interestingly, these cells grew faster than high-ADRB2 LNCaP cells, and sustained their low glucuronidation activity in castrated NOD/SCID mice. ADRB2 immunohistochemical staining intensity correlated with UGT2B15 staining intensity in independent TMA studies and with UGT2B17 in one TMA study. Similar to ADRB2, we show that low levels of UGT2B15 are associated with a more rapid CRPC progression. We propose a novel mechanism by which ADRB2 may affect the development of CRPC through downregulation of UGT2B15 and UGT2B17.

• Manfra, Ornella; Van Craenenbroeck, Kathleen; Skieterska, Kamila; Frimurer, Thomas; Schwartz, Thue W. & Levy, Finn Olav [Show all 7 contributors for this article] (2015). Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1. ACS Chemical Neuroscience. ISSN 1948-7193. 6(7), p. 1206–1218. doi: 10.1021/cn500339p.
• Andressen, Kjetil Wessel; Manfra, Ornella; Brevik, Christian Hellesylt; Ulsund, Andrea Hembre; Vanhoenacker, Peter & Levy, Finn Olav [Show all 7 contributors for this article] (2015). The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors. British Journal of Pharmacology. ISSN 0007-1188. 172(15), p. 3846–3860. doi: 10.1111/bph.13169.
• Ørstavik, Øivind; Manfra, Ornella; Andressen, Kjetil Wessel; Andersen, Geir Øystein; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 8 contributors for this article] (2015). The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium. PLOS ONE. ISSN 1932-6203. 10(3). doi: 10.1371/journal.pone.0115547. Full text in Research Archive
• Impellizzeri, Agata Antonina Rita; Pappalardo, Matteo; Basile, Livia; Manfra, Ornella; Andressen, Kjetil Wessel & Krobert, Kurt Allen [Show all 9 contributors for this article] (2015). Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis. Frontiers in Behavioral Neuroscience. ISSN 1662-5153. 9(MAY). doi: 10.3389/fnbeh.2015.00092. Full text in Research Archive
• Olberg, Dag Erlend; Hausner, Sven H.; Bauer, Nadine; Klaveness, Jo; Indrevoll, Bård & Andressen, Kjetil Wessel [Show all 10 contributors for this article] (2015). Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats. MedChemComm. ISSN 2040-2503. 6, p. 708–714. doi: 10.1039/c4md00486h.
• Ørstavik, Øivind; Ata, Salmana H; Riise, Jon; Dahl, Christen Peder; Andersen, Geir Øystein & Levy, Finn Olav [Show all 9 contributors for this article] (2014). Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart. British Journal of Pharmacology. ISSN 0007-1188. 171(23), p. 5169–5181. doi: 10.1111/bph.12647.
• Melsom, Elin Maria Caroline Bull; Ørstavik, Øivind; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav & Krobert, Kurt Allen (2014). Gi proteins regulate adenylyl cyclase activity independent of receptor activation. PLoS Medicine. ISSN 1549-1277. 9:e0106608(9). doi: 10.1371/journal.pone.0106608. Full text in Research Archive
• Melsom, Elin Maria Caroline Bull; Hussain, Rizwan; Ørstavik, Øivind; Aronsen, Jan Magnus; Sjaastad, Ivar & Skomedal, Tor [Show all 9 contributors for this article] (2014). Non-classical regulation of β1- and β2 adrenoceptor- mediated inotropic responses in rat ventricle by the G protein Gi. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(12), p. 1177–1186. doi: 10.1007/s00210-014-1036-7.
• Brudeli, Bjarne; Navaratnarajah, Mirusha; Andressen, Kjetil Wessel; Manfra, Ornella; Moltzau, Lise Roman & Nilsen, Nils Olav [Show all 8 contributors for this article] (2014). Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(18), p. 4598–4602. doi: 10.1016/j.bmcl.2014.06.083.
• Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira Hebold & Sutcliffe, Julie L. (2014). Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(7), p. 1846–1850. doi: 10.1016/j.bmcl.2014.02.002.
• Kilander, Michael Brita Christina; Petersen, Julian; Andressen, Kjetil Wessel; Ganji, Ranjani Sri; Levy, Finn Olav & Schuster, Jens [Show all 9 contributors for this article] (2014). Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6. The FASEB Journal. ISSN 0892-6638. 28(5), p. 2293–2305. doi: 10.1096/fj.13-246363.
• Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Skogestad, Jonas; Ørstavik, Øivind & Lothe, Gustav B [Show all 11 contributors for this article] (2014). Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. doi: 10.1124/jpet.114.214882.
• Moltzau, Lise Roman; Meier, Silja; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar & Skomedal, Tor [Show all 9 contributors for this article] (2014). Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(5), p. 407–417. doi: 10.1007/s00210-013-0953-1.
• Bach, Trond; Bergholtz, Stine Louise; Riise, Jon; Qvigstad, Eirik; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 7 contributors for this article] (2014). Identification of small molecule NPR-B antagonists by high throughput screening - potential use in heart failure. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(1), p. 5–14. doi: 10.1007/s00210-013-0940-6.
• Brudeli, Bjarne; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Andressen, Kjetil Wessel; Nilsen, Nils Olav & Levy, Finn Olav [Show all 7 contributors for this article] (2013). Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European Journal of Medicinal Chemistry. ISSN 0223-5234. 64, p. 629–637. doi: 10.1016/j.ejmech.2013.03.060.
• Brudeli, Bjarne; Andressen, Kjetil Wessel; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 21(22), p. 7134–7145. doi: 10.1016/j.bmc.2013.09.004.
• Gravning, Jørgen A.; Ahmed, Muhammad Shakil; Qvigstad, Eirik; Krobert, Kurt Allen; Edvardsen, Thor & Moe, Ingvild Tronstad [Show all 13 contributors for this article] (2013). Connective Tissue Growth Factor/CCN2 Attenuates beta-Adrenergic Receptor Responsiveness and Cardiotoxicity by Induction of G Protein-Coupled Receptor Kinase-5 in Cardiomyocytes. Molecular Pharmacology. ISSN 0026-895X. 84(3), p. 372–383. doi: 10.1124/mol.113.087312.
• Levay, Magdolna; Krobert, Kurt Allen; Wittig, Karola; Voigt, Niels; Bermudez, Marcel & Wolber, Gerhard [Show all 9 contributors for this article] (2013). NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. 347(1), p. 69–79. doi: 10.1124/jpet.113.207266.
• Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Hougen, Karina & Ørstavik, Øivind [Show all 12 contributors for this article] (2013). SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium. British Journal of Pharmacology. ISSN 0007-1188. 170(2), p. 366–379. doi: 10.1111/bph.12282.
• Gellynck, Evelien; Heyninck, Karen; Andressen, Kjetil Wessel; Haegeman, Guy; Levy, Finn Olav & Vanhoenacker, Peter [Show all 7 contributors for this article] (2013). The serotonin 5-HT7 receptors: two decades of research. Experimental Brain Research. ISSN 0014-4819. 230(4), p. 555–568. doi: 10.1007/s00221-013-3694-y.
• Molenaar, Peter; Christ, Torsten; Hussain, Rizwan; Engel, Andreas; Berk, Emanuel & Gillette, Katherine T. [Show all 12 contributors for this article] (2013). PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients. British Journal of Pharmacology. ISSN 0007-1188. 169(3), p. 528–538. doi: 10.1111/bph.12167.
• Hussain, Rizwan; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Osnes, Jan-Bjørn & Skomedal, Tor [Show all 8 contributors for this article] (2013). The functional activity of inhibitory G protein (Gi) is not increased in failing heart ventricle. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 56, p. 129–138. doi: 10.1016/j.yjmcc.2012.11.015.
• Riise, Jon; Nguyen, Hong Cam Thi; Hussain, Rizwan; Dahl, Christen Peder; Ege, Maren Stapnes & Osnes, Jan-Bjørn [Show all 10 contributors for this article] (2012). Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium. European Journal of Pharmacology. ISSN 0014-2999. 686(1-3), p. 66–73. doi: 10.1016/j.ejphar.2012.04.022.
• Riise, Jon; Ørstavik, Øivind; Qvigstad, Eirik; Dahl, Christen Peder; Osnes, Jan-Bjørn & Skomedal, Tor [Show all 8 contributors for this article] (2012). Prostaglandin E-1 facilitates inotropic effects of 5-HT4 serotonin receptors and beta-adrenoceptors in failing human heart. Basic Research in Cardiology. ISSN 0300-8428. 107(5). doi: 10.1007/s00395-012-0295-z.
• Bilbija, Dusan; Haugen, Fred; Sagave, Julia Fritzi; Baysa, Anton; Bastani, Nasser Ezzatkhah & Levy, Finn Olav [Show all 9 contributors for this article] (2012). Retinoic Acid Signalling Is Activated in the Postischemic Heart and May Influence Remodelling. PLOS ONE. ISSN 1932-6203. 7(9). doi: 10.1371/journal.pone.0044740.
• Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise & Birkeland, Jon Arne [Show all 10 contributors for this article] (2012). The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure. PLOS ONE. ISSN 1932-6203. 7(9). doi: 10.1371/journal.pone.0045489. Full text in Research Archive
• Gellynck, Evelien; Andressen, Kjetil Wessel; Lintermans, Béatrice; Haegeman, Guy; Levy, Finn Olav & Vanhoenacker, Peter [Show all 7 contributors for this article] (2012). Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor. The FEBS Journal. ISSN 1742-464X. 279(11), p. 1994–2003. doi: 10.1111/j.1742-4658.2012.08581.x.
• von Lueder, Thomas Gero; Gravning, Jørgen A.; How, Ole-Jakob; Vinge, Leif Erik; Ahmed, Muhammad Shakil & Krobert, Kurt Allen [Show all 11 contributors for this article] (2012). Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 303(1), p. H66–H74. doi: 10.1152/ajpheart.00724.2011.
• Brattelid, Trond & Levy, Finn Olav (2011). Quantification of GPCR mRNA Using Real-Time RT-PCR. Methods in molecular biology. ISSN 1064-3745. 746(3), p. 165–193. doi: 10.1007/978-1-61779-126-0_9.
• Berrade, Luis; Aisa, Bárbara; Ramirez, María; Galiano, Silvia; Guccione, Salvatore & Moltzau, Lise Roman [Show all 13 contributors for this article] (2011). Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action. Journal of Medicinal Chemistry. ISSN 0022-2623. 54(8), p. 3086–3090. doi: 10.1021/jm2000773.
• Afzal, Faraz; Qvigstad, Eirik; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar & Skomedal, Tor [Show all 8 contributors for this article] (2011). Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 384(6), p. 543–553. doi: 10.1007/s00210-011-0670-6.
• Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav & Skomedal, Tor [Show all 8 contributors for this article] (2011). Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle. British Journal of Pharmacology. ISSN 0007-1188. 162(1), p. 54–71. doi: 10.1111/j.1476-5381.2010.00890.x.
• Hussain, Rizwan; Afzal, Faraz; Mørk, Halvor Kjeang; Aronsen, Jan Magnus; Sjaastad, Ivar & Osnes, Jan-Bjørn [Show all 9 contributors for this article] (2011). Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. British Journal of Pharmacology. ISSN 0007-1188. 162(4), p. 908–916. doi: 10.1111/j.1476-5381.2010.01097.x.
• Brudeli, Bjarne; Moltzau, Lise Roman; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Klaveness, Jo & Levy, Finn Olav (2010). Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 18(24), p. 8600–8613. doi: 10.1016/j.bmc.2010.10.011.
• Brattelid, Trond; Winer, Lisbeth Hagen; Levy, Finn Olav; Liestøl, Knut; Sejersted, Ole M & Andersson, Kristin Brevik (2010). Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies. BMC Molecular Biology. ISSN 1471-2199. 11. doi: 10.1186/1471-2199-11-22.
• Qvigstad, Eirik; Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Hougen, Karina & Sjaastad, Ivar [Show all 9 contributors for this article] (2010). Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition. Cardiovascular Research (CVR). ISSN 0008-6363. 85(4), p. 763–772. doi: 10.1093/cvr/cvp364.
• Hussain, RI; Qvigstad, Eirik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A & Sjaastad, Ivar [Show all 10 contributors for this article] (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology. ISSN 0007-1188. 156(4), p. 575–586. doi: 10.1111/j.1476-5381.2009.00016.x.
• Kjekshus, John; Torp-Pedersen, C; Gullestad, Lars; Kober, L; Edvardsen, Thor & Olsen, IC [Show all 11 contributors for this article] (2009). Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. European Journal of Heart Failure. ISSN 1388-9842. 11(8), p. 771–778. doi: 10.1093/eurjhf/hfp087.
• Hussain, Rizwan; Qvigstad, Erik; Birkeland, Jon Arne; Eikemo, Hilde; Glende, A & Sjaastad, Ivar [Show all 10 contributors for this article] (2009). Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. British Journal of Pharmacology. ISSN 0007-1188. 156(4), p. 575–586. doi: 10.1111/j.1750-3639.2009.00016.x. Show summary

  Background and purpose: Muscarinic stimulation increases myofilament Ca2+ sensitivity with no apparent inotropic response in normal rat myocardium. Increased myofilament Ca2+ sensitivity is a molecular mechanism promoting increased contractility in failing cardiac tissue. Thus, muscarinic receptor activation could elicit inotropic responses in ventricular myocardium from rats with heart failure, through increasing phosphorylation of myosin light chain (MLC). Experimental approach: Contractile force was measured in left ventricular papillary muscles from male Wistar rats, 6 weeks after left coronary artery ligation or sham surgery. Muscles were also frozen, and MLC‐2 phosphorylation level was quantified. Key results: Carbachol (10 µmol·L−1) evoked a positive inotropic response only in muscles from rats with heart failure approximating 36% of that elicited by 1 µmol·L−1 isoproterenol (20 ± 1.5% and 56 ± 6.1% above basal respectively). Carbachol‐evoked inotropic responses did not correlate with infarction size but did correlate with increased left ventricular end diastolic pressure, heart weight/body weight ratio and lung weight, primary indicators of the severity of heart failure. Only muscarinic receptor antagonists selective for M2 receptors antagonized carbachol‐mediated inotropic effects with the expected potency. Carbachol‐evoked inotropic responses and increase in phosphorylated MLC‐2 were attenuated by MLC kinase (ML‐9) and Rho‐kinase inhibition (Y‐27632), and inotropic responses were abolished by Pertussis toxin pretreatment. Conclusion and implications: In failing ventricular muscle, muscarinic receptor activation, most likely via M2 receptors, provides inotropic support by increasing MLC phosphorylation and consequently, myofilament Ca2+ sensitivity. Enhancement of myofilament Ca2+ sensitivity, representing a less energy‐demanding mechanism of inotropic support may be particularly advantageous in failing hearts.

• Eikemo, Hilde; Skomedal, Tor; Levy, Finn Olav & Osnes, Jan-Bjørn (2008). Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors. Analytical Biochemistry. ISSN 0003-2697. 383(2), p. 323–325. doi: 10.1016/j.ab.2008.09.011.
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• Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 9 contributors for this article] (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology. ISSN 2050-6511. 16, p. A66–A66. doi: 10.1186/2050-6511-16-S1-A66.
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• Levy, Finn Olav (2013). Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 386(8), p. 665–670. doi: 10.1007/s00210-013-0874-z.
• Dugstad, Kari Sandanger; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Zaccolo, Manuela & Levy, Finn Olav (2012). Compartmented production and degradation of cAMP by beta-adrenergic, prostanoid and 5-HT4 receptors in CHF, visualized by FRET-based cAMP sensors.
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• Meier, Silja; Aronsen, Jan Magnus; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2010). C-type natriuretic peptide signalling through NPR-B enhances the B1-AR signalling both in non-failing and failing rat hearts.
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• Levy, Finn Olav (2008). Antagonist-mediated down-regulation of 5-HT7 receptors by the atypical antipsychotics clozapine and olanzapine: evidence for functional selectivity. Fundamental & Clinical Pharmacology. ISSN 0767-3981. 22, p. 60–60.
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