For å studere disse utløsende og regulerende for cholangitt benyttes humant materiale, ulike musemodeller for cholangitt og organ-on-a-chip systemer.
Vi benytter også sekvenseringsbaserte teknikker med spatial transcriptomics og single-cell sequencing.
Les mer om forskningen vår på våre engelske gruppesider.
Publikasjoner
Under finner du forskergruppens siste publikasjoner i PubMed.
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T cells with increased responsiveness cause obesity in mice without diet intervention 29. mars 2024 10:00Gregersen I, Kong XY, Kooijman S, Foyn H, Grannes H, Olsen MB, Lone AM, Yang K, Quiles-Jiménez A, Tran M, Øgaard J, Segers FM, Rashidi A, Sagen EL, Lauritzen KH, Pronk ACM, de Boer JF, Holven KB, Melum E, Aukrust P, Taskén K, Holm S, Rensen PCN, Dahl TB, Halvorsen B (2024) T cells with increased responsiveness cause obesity in mice without diet intervention iScience, 27 (4), 109471 PubMed 38551005 DOI 10.1016/j.isci.2024.109471
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Cell-Free Microbial DNA Analysis: Effects of Blood Plasma and Serum Quantity, Biobanking Protocols, and Isolation Kits 28. feb. 2024 10:00Nikitina D, Lukosevicius R, Tilinde D, Muskieta T, Hov JR, Melum E, Klovins J, Org E, Kiudelis G, Kupcinskas J, Skieceviciene J (2024) Cell-Free Microbial DNA Analysis: Effects of Blood Plasma and Serum Quantity, Biobanking Protocols, and Isolation Kits Biopreserv Biobank PubMed 38416864 DOI 10.1089/bio.2023.0048
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Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion 9. feb. 2024 10:00Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS (2024) Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion Nature, 626 (8001), E19 PubMed 38336833 DOI 10.1038/s41586-024-07164-y
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Microbial exposure during early life regulates development of bile duct inflammation 24. nov. 2023 10:00Oldereid TS, Jiang X, Øgaard J, Schrumpf E, Bjørnholt JV, Rasmussen H, Melum E (2024) Microbial exposure during early life regulates development of bile duct inflammation Scand J Gastroenterol, 59 (2), 192-201 PubMed 37997753 DOI 10.1080/00365521.2023.2278423
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Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation 23. nov. 2023 10:00Jiang X, Otterdal K, Chung BK, Maucourant C, Rønneberg JD, Zimmer CL, Øgaard J, Boichuk Y, Holm S, Geanon D, Schneditz G, Bergquist A, Björkström NK, Melum E (2023) Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation Gastroenterology, 166 (4), 667-679 PubMed 37995866 DOI 10.1053/j.gastro.2023.11.283
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Role of bacteria and microbial metabolites in immune modulation during early life 5. mars 2024 10:00Oldereid TS, Jiang X, Nordhus KS, Ponzetta A, Bjørnholt JV, Björkström NK, Melum E, Rasmussen H (2023) Role of bacteria and microbial metabolites in immune modulation during early life Scand J Immunol, 99 (2), e13336 PubMed 38441196 DOI 10.1111/sji.13336
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Scalable production of tissue-like vascularized liver organoids from human PSCs 31. aug. 2023 11:00Harrison SP, Siller R, Tanaka Y, Chollet ME, de la Morena-Barrio ME, Xiang Y, Patterson B, Andersen E, Bravo-Pérez C, Kempf H, Åsrud KS, Lunov O, Dejneka A, Mowinckel MC, Stavik B, Sandset PM, Melum E, Baumgarten S, Bonanini F, Kurek D, Mathapati S, Almaas R, Sharma K, Wilson SR, Skottvoll FS, Boger IC, Bogen IL, Nyman TA, Wu JJ, Bezrouk A, Cizkova D, Corral J, Mokry J, Zweigerdt R, Park IH, Sullivan GJ (2023) Scalable production of tissue-like vascularized liver organoids from human PSCs Exp Mol Med, 55 (9), 2005-2024 PubMed 37653039 DOI 10.1038/s12276-023-01074-1
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Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation 16. juni 2023 11:00Braadland PR, Bergquist A, Kummen M, Bossen L, Engesæter LK, Reims HM, Björk I, Grzyb K, Abildgaard A, Småstuen MC, Folseraas T, Trøseid M, Ulvik A, Ueland PM, Melum E, Line PD, Høivik ML, Grønbæk H, Karlsen TH, Vesterhus M, Hov JR (2023) Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation J Hepatol, 79 (4), 955-966 PubMed 37328069 DOI 10.1016/j.jhep.2023.05.038
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Long-term survival after liver transplantation in patients with common variable immunodeficiency 18. mars 2023 10:00Andersen IM, Reims HM, Grzyb K, Fevang B, Melum E, Aukrust P, Wiencke K, Nordøy I, Line PD, Jørgensen SF (2023) Long-term survival after liver transplantation in patients with common variable immunodeficiency Liver Transpl, 29 (8), 894-899 PubMed 36932715 DOI 10.1097/LVT.0000000000000130
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Pump-less, recirculating organ-on-a-chip (rOoC) platform 19. jan. 2023 10:00Busek M, Aizenshtadt A, Koch T, Frank A, Delon L, Martinez MA, Golovin A, Dumas C, Stokowiec J, Gruenzner S, Melum E, Krauss S (2023) Pump-less, recirculating organ-on-a-chip (rOoC) platform Lab Chip, 23 (4), 591-608 PubMed 36655405 DOI 10.1039/d2lc00919f