Selected Publications
Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1 / 2 Pathway. Szybowska P, Kostas M, Wesche J, Wiedlocha A, Haugsten EM, Cells. May 29; 8 (6) 2019. Pubmed
Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling. Zakrzewska M, Opalinski L, Haugsten EM , Otlewski J, Wiedlocha A, Int J Mol Sci, 20 (8) 2019. Pubmed
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors. Kostas M , Haugsten EM , Zhen Y , Sørensen V , Szybowska P , Fiorito E , Lorenz S , Jones N, de Souza GA, Wiedlocha A , Wesche J. Molecular & Cellular Proteomics, 2018 May . PubMed
Proximity Labeling by a Recombinant APEX2-FGF1 Fusion Protein Reveals Interaction of FGF1 with the Proteoglycans CD44 and CSPG4. Zhen Y , Haugsten EM , Singh SK , Wesche J. Biochemistry, 2018 Jul . PubMed
The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases. Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M, Jonatova L, Cernohorsky NH, Zieba JT, Kostas M , Haugsten EM , Wesche J , Erneux C , Trantirek L, Krakow D, Krejci P. Sci Signal. 2018 Sep. PubMed