Ivan Dikic: Keynote Speaker
Institute of Biochemistry II and Max Planck Institute for Biophysics, Goethe University, Frankfurt / Main, Germany, @ idikic2 Email: dikic@biochem2.uni-frankfurt.de
PROXIDRUGS: new therapeutics for multiple diseases
The new class of proximity-inducing drugs allows for the Ubiquitin-dependent degradation of disease-relevant target structures (proteins, nucleic acids, organelles) thus opening up new therapeutic options in numerous diseases. The respective drugs usually are small, bifunctional molecules which directly target structures straight towards the cellular waste system. While 80% of proteins are still deemed to be undruggable, a large proportion of these are thought to be targetable by the new strategy. Together with academic and industrial partners, Goethe University Frankfurt has established the BMBF-funded Cluster4Future PROXIDRUGS. Key piece of the Cluster is a technology platform for drug discovery and preclinical development.The Cluster aims at systematically improving the new class of proximity-inducing drugs and establishing a toolbox that can be quickly adapted to different target structures and disease settings. The Cluster comprises ten different research projects focusing on cutting-edge challenges, such as the development of novel degradation strategies, use of tissue specific Ubiquitin ligases, the solubility enhancement of target proteins, the creation of proximity-based agents against cancer, bacterial and viral pathogens. The research projects are accompanied by an integrative facilities and available screening libraries at the newly establishedsuch as the development of novel degradation strategies, use of tissue specific Ubiquitin ligases, the solubility enhancement of target proteins, the creation of proximity-based agents against cancer, bacterial and viral pathogens. The research projects are accompanied by an integrative facilities and available screening libraries at the newly established such as the development of novel degradation strategies, use of tissue specific Ubiquitin ligases, the solubility enhancement of target proteins, the creation of proximity-based agents against cancer, bacterial and viral pathogens. The research projects are accompanied by an integrative facilities and available screening libraries at the newly established Frankfurt Center for Innovation and Technologies .
Program:
11:00: Welcome address (Harald / Anne)
11:10: Keynote lecture guest professor Ivan Dikic: " PROXIDRUGS: new therapeutics for multiple diseases "
12:00: Kaisa Haglund: “Cytokinetic abscission in vivo”
12:30: Nathalia Chica: “Intelligent algorithms reveal the functional landscape of temporal dynamics of autophagy - a path towards tuning autophagy”
* 13: 00-14: 00 Lunch (Medica Spiceri, Domus Medica) *
14:00: Matthew Ng: "GRAMD1C regulates autophagy initiation and mitochondrial cholesterol transport."
14:30: Michal Kostas: "Activation of unliganded FGFR1 by inorganic phosphate and oxidative stress"
15:00: Eva Wenzel: "TKS4 and TKS5 promote the long-distance ECM degradative potential of MT1-MMP"
* 15: 30 Break w / refreshments *
16: 00-17: 00: Panel discussion 17:15 Bus departure to Ekebergsletta
* 18: 00- Social event Ekebergsletta (BBQ & drinks, cricket, leisure games) *