Emma Joanna Lengle

Doctoral Research Fellow - Department of Community Medicine and Global Health

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Email e.j.lengle@medisin.uio.no

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Visiting address Kirkeveien 166 Fredrik Holsts hus 0450 Oslo

Postal address Postboks 1130 Blindern 0318 Oslo

Other affiliations Faculty of Medicine (Student)

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Academic interests

Emma joined the Department of Community Medicine and Global Health within the Institute for Health and Society as a doctoral research fellow in 2022. She is a medical doctor and holds a Master of Public Health from Harvard University.

Her thesis explores the role of normative frameworks, contested evidence, and participatory practice in the Oslo City Public Health Strategy for 2023-2030, which aims to reduce the city's growing levels of social inequality in health. She is particularly interested in the impact of the policymaking process itself on the pursuit of more equitable futures. Her work applies theories and methods of policy research at the intersection of anthropology, sociology, and science studies (STS) to public health policy in Norway.

Emma is an affiliate researcher at the Center for Sustainable Healthcare Education. She is also a Commissioner on the Oslo-Lancet Commission on Global Governance for Health launched in 2023.

Courses taught

Emma has taught a variety of social medicine seminars at the University of Oslo and Harvard University. She is particularly inspired by teaching opportunities that engage questions of health equity, antiracist medical practice, and redistributive health policy.

Background

2022: Master of Public Health, Harvard University
Spring 2022: Project coordinator, Physicians for Human Rights
2021: MD, University of Oslo
2020-2021: Medical student with authorization, Oslo Public Emergency Care Ward
2020: MD/PhD track in medical genetics, Oslo University Hospital
Fall 2019: Intern, UNICEFs Regional Office for the Middle East and North Africa
Spring 2019: OB/GYN and community pediatrics, University of New South Wales, Australia

Awards

Aker Scholarship 2021-2022

Center for Sustainable Healthcare Education stipend for the podcast Folkefeber 2020

Norwegian Ministry of Foreign Affairs UN internship scholarship 2019

Appointments

Commissioner, Lancet Commission on Global Governance for Health 2023-
National chair, Norwegian Medical Students' Humanitarian campaign 2016-2018
Board member, UiO Medical Student Society 2015-2016
Board member, Oslo Doctor's Association 2015-2016
Chair, Norwegian Medical Students' Association Oslo 2015-2016
Board member, Norwegian Medical Students' Association Oslo 2014-2015

Yaddehi Gamage, Thilini Hansamali Gamage; Lengle, Emma; Gunnes, Gjermund; Pullisaar, Helen; Holmgren, Asbjørn & Reseland, Janne Elin [Show all 16 contributors for this article] (2019). STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone. Cell Calcium. ISSN 0143-4160. 85. doi: 10.1016/j.ceca.2019.102110.
Yaddehi Gamage, Thilini Hansamali Gamage; Gunnes, Gjermund; Lee, Robert Hugh; Louch, William Edward; Holmgren, Asbjørn & Bruton, Joseph D. [Show all 19 contributors for this article] (2018). STIM1 R304W causes muscle degeneration and impaired platelet activation in mice. Cell Calcium. ISSN 0143-4160. 76, p. 87–100. doi: 10.1016/j.ceca.2018.10.001. Full text in Research Archive Show summary
STIM1 and ORAI1 regulate store-operated Ca2+ entry (SOCE) in most cell types, and mutations in these proteins have deleterious and diverse effects. We established a mouse line expressing the STIM1 R304 W gain-of-function mutation causing Stormorken syndrome to explore effects on organ and cell physiology. While STIM1 R304 W was lethal in the homozygous state, surviving mice presented with reduced growth, skeletal muscle degeneration, and reduced exercise endurance. Variable STIM1 expression levels between tissues directly impacted cellular SOCE capacity. In contrast to patients with Stormorken syndrome, STIM1 was downregulated in fibroblasts from Stim1R304W/R304W mice, which maintained SOCE despite constitutive protein activity. In studies using foetal liver chimeras, STIM1 protein was undetectable in homozygous megakaryocytes and platelets, resulting in impaired platelet activation and absent SOCE. These data indicate that downregulation of STIM1 R304 W effectively opposes the gain-of-function phenotype associated with this mutation, and highlight the importance of STIM1 in skeletal muscle development and integrity.

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Spjeldnæs, Amanda Hylland; Patel, Davina Kaur; Lichtwarck, Hanne Ochieng; Givan, Kathleen Alexandra; Gravdahl, Oline Friestad & Lengle, Emma Joanna (2023). Legeopprop for sivilbefolkningen på Gaza. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(17). doi: 10.4045/tidsskr.23.0713.
Engebretsen, Eivind; Sørly, Rita; Lengle, Emma Joanna; Walsh, Tricia; Clark, Helen & Helm, Sarah [Show all 7 contributors for this article] (2023). Webinar - Minimising social and health harms from methamphetamine use in Norway and New Zealand. [Internet]. zoom seminar.

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Published Sep. 27, 2022 8:56 AM - Last modified Dec. 7, 2023 3:29 PM