Randi Opheim

• Salihovic, Samira; Nyström, Niklas; Mathisen, Charlotte Bache-Wiig; Kruse, Robert; Olbjørn, Christine & Andersen, Svend [Show all 30 contributors for this article] (2024). Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease. Nature Communications. ISSN 2041-1723. doi: 10.1038/s41467-024-48763-7. Show summary

  Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.

• Maurud, Sigurd; Lunde, Lene; Moen, Anne & Opheim, Randi (2024). Exploring the foundations of a digital health information service for patients with inflammatory bowel disease: a mixed method study in Gravitate-Health. BMC Gastroenterology. ISSN 1471-230X. 24(1). doi: 10.1186/s12876-024-03272-1.
• Strande, Vibeke; Lund, Charlotte; Hagen, Milada; Bengtson, May-Bente; Boyar Cetinkaya, Raziye & Detlie, Trond Espen [Show all 23 contributors for this article] (2024). Clinical course of ulcerative colitis: Frequent use of biologics and low colectomy rate first year after diagnosis—results from the IBSEN III inception cohort. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. doi: 10.1111/apt.18097. Show summary

  Background: The introduction of biologic therapies and the 'treat-to-target' treatment strategy may have changed the disease course of ulcerative colitis (UC). Aims: To describe the early disease course and disease outcome at 1-year follow-up in a population-based inception cohort of adult patients with newly diagnosed UC. Methods: The Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III study is a population-based inception cohort study with prospective follow-up. Patients newly diagnosed with inflammatory bowel disease during 2017-2019 were included. Patients ≥18 years at diagnosis of UC who attended the 1-year follow-up were investigated. We registered clinical, endoscopic and demographic data at diagnosis and 1-year follow-up. Results: We included 877 patients with UC (median age 36 years (range: 18-84), 45.8% female). At diagnosis, 39.2% presented with proctitis, 24.7% left-sided colitis and 36.0% extensive colitis. At the 1-year follow-up, 13.9% experienced disease progression, and 14.5% had received one or more biologic therapies. The colectomy rate was 0.9%. Steroid-free clinical remission was observed in 76.6%, and steroid-free endoscopic remission in 68.7%. Anaemia and initiation of systemic steroid treatment at diagnosis were associated with biologic therapy within the first year after diagnosis. Conclusion: In this population-based inception cohort, colectomy rate in the first year after diagnosis was low, and a high proportion of patients were in remission at 1-year follow-up. The use of biologic therapy increases, consistent with findings from previous studies.

• Zerouga, Insaf; Valeur, Jørgen; Sommer, Christine; Småstuen, Milada Cvancarova; Medhus, Asle Wilhelm & Lund, Charlotte [Show all 22 contributors for this article] (2024). Dietary intake and nutritional status in patients with newly diagnosed inflammatory bowel disease: insights from the IBSEN III study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. p. 1–9. doi: 10.1080/00365521.2024.2313056. Show summary

  Background: Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim of this study was to compare dietary intakes and nutritional status in men and women with newly diagnosed IBD with a general population sample, and to investigate whether intakes were in line with the Nordic Nutrition Recommendations. Methods: This was a cross-sectional study including adults≥ 40 years with IBD from the Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III cohort study. A validated food frequency questionnaire (FFQ) was used in dietary data collection, and a sample from the seventh survey of the Tromsø Study was included as a comparison group. Results: A total of 227 men and women with IBD were included. IBD patients had higher intake of grain products, sweetened beverages, energy, fat and polyunsaturated fat (PUFA), but lower intake of dairy products, alcohol and iodine compared to adults from the comparison sample (p < 0.01). Intakes of saturated fat and carbohydrates in both genders, and vitamin D in women were not within recommended levels. Anemia and hypoalbuminemia were more prevalent in IBD patients than in the comparison sample. Conclusions: Dietary intakes in newly diagnosed IBD patients were mostly in line with Nordic Nutrition Recommendations. Higher proportion of IBD patients exceeded recommended allowances of fat and added sugar than the comparison sample. Insufficient micronutrient intake, anemia and hypoalbuminemia are present challenges in IBD patients that require monitoring.

• Mølsæter, Anne Britt; Henni, Silje Havrevold; Opheim, Randi; Høye, Sigurd & Børøsund, Elin (2023). Antibiotikasmarte sykepleierstudenter? Sykepleierstudenters kunnskap og egenvurdert kompetanse om antibiotikabruk og -resistens. Sykepleien Forskning. ISSN 1890-2936. 18, p. 1–13. doi: 10.4220/Sykepleienf.2023.93743. Show summary

  Bakgrunn: Moderne medisin er avhengig av virksom antibiotika. Imidlertid har antibiotikaresistens blitt et raskt voksende problem i verden, som utgjør en alvorlig trussel mot den globale helsen. Riktig antibiotikabruk er avgjørende for å redusere antibiotikaresistensen i fremtiden. Norske sykepleierstudenters kunnskapsnivå om antibiotikabruk og -resistens er lite utforsket. Hensikt: Å kartlegge sykepleierstudenters kunnskap om antibiotikaresistens og antibiotikabruk. Vi ønsket også å undersøke hvordan de vurderer sin egen kompetanse på dette området. Metode: Studien har et deskriptivt tverrsnittsdesign. Dataene ble samlet inn via et spørreskjema utdelt til sykepleierstudenter ved fire utvalgte utdanningsinstitusjoner fra september 2019 til februar 2020. Kartleggingen besto av et spørreskjema med 43 spørsmål, fordelt på ni spørsmål om egenvurdering av kunnskap og 34 kunnskapsspørsmål om antibiotikabruk inndelt i seks temaer. Vi anvendte ANOVA, t-tester og bivariate korrelasjonsanalyser for å vurdere sammenhengen mellom faktisk kunnskap om antibiotikabruk og egenvurdering av kunnskap, tidligere arbeidserfaring i helsevesenet, frivillig eller obligatorisk undervisning, undervisningssted og alder. Resultat: Av 480 forespurte studenter deltok 410 (84,5 prosent) i studien. Studentene hadde en gjennomsnittskår på 48,6 prosent korrekte svar for alle kunnskapsspørsmålene samlet. De hadde minst kunnskap om temaene om antibiotikaforbruk, urinveisinfeksjon og asymptomatisk bakteriuri samt allergi og bivirkninger. En høy andel av studentene vurderte sin egen kunnskap om antibiotikaresistens og riktig antibiotikabruk som lav. Jo høyere studentene skåret på kunnskapsnivå, jo høyere vurderte de sin egen kunnskap. Verken alder, tidligere jobberfaring, eller hvorvidt undervisningen var frivillig eller obligatorisk, hadde sammenheng med kunnskapsnivået. Konklusjon: Sykepleierstudenter har mangelfull kunnskap om antibiotikaresistens og riktig antibiotikabruk, og de vurderer også selv at de har lite kunnskap og lav kompetanse. Resultatene indikerer et behov for å styrke studentenes kompetanse, slik at de kan benytte sin profesjon bedre til å påvirke og forebygge antibiotikaresistens. Videre forskning bør undersøke om kunnskapsnivået er forbedret etter at flere av studiestedene har satt i gang undervisning etter at studien ble utført.

• Svendsen, Edel Jannecke; Opheim, Randi; Hermansen, Bjørg Elisabeth & Hardeland, Camilla (2023). Ad hoc digital communication and assessment during clinical placements in nursing education; a qualitative research study of students', clinical instructors', and teachers' experiences. PLOS ONE. ISSN 1932-6203. 18(7), p. 1–14. doi: 10.1371/journal.pone.0287438.
• Lindemann, Kristina Yvonne Kathe; Danbolt, Svana Heimisdottir; Ramberg, Lene Kristine Marsby; Eyjólfsdóttir, Brynhildur; Wang, Yun & Heli-Haugestøl, Anne Gjertine [Show all 15 contributors for this article] (2023). Patient-reported nausea after implementation of an enhanced recovery after surgery protocol for gynae-oncology patients. International Journal of Gynecological Cancer. ISSN 1048-891X. 33(8), p. 1287–1294. doi: 10.1136/ijgc-2023-004356. Full text in Research Archive
• Johansen, Ingunn; Småstuen, Milada Cvancarova; Løkkeberg, Stine Eileen Torp; Kristensen, Vendel Ailin; Høivik, Marte Lie & Lund, Charlotte [Show all 16 contributors for this article] (2023). Symptoms and symptom clusters in patients newly diagnosed with inflammatory bowel disease: results from the IBSEN III Study. BMC Gastroenterology. ISSN 1471-230X. 23(1). doi: 10.1186/s12876-023-02889-y. Full text in Research Archive Show summary

  Patients with inflammatory bowel disease report multiple symptoms, but the relationships among co-occurring symptoms are poorly understood. This study aimed to examine the prevalence of symptoms and explore symptom clusters and possible associations between symptom clusters and socio-demographic and clinical variables in patients newly diagnosed with inflammatory bowel disease. Methods The IBSEN III study is a prospective population-based inception cohort of patients with inflammatory bowel disease. This study used patient data from the three largest hospitals in the study catchment area. The Memorial Symptom Assessment Scale was used to assess the prevalence of symptoms. Symptom clusters were identified using principal component analysis. Possible associations between socio-demographic and clinical variables and symptom cluster membership were estimated using regression analysis. Results Of the 573 patients (age, ≥18 years) diagnosed with inflammatory bowel disease, 350 (61.1%) completed the questionnaire (responders). Eleven symptoms were reported by >50% of the responders. The three most prevalent symptoms were bloating (84%), drowsiness (81%), and lack of energy (81%). Three symptom clusters were identified: psychological (56% of the patients), impaired energy (28%), and physical (16%) clusters. Multinomial regression analysis revealed that vitamin D deficiency was significantly associated with the impaired energy cluster (odds ratio=2.49, 95% confidence interval [1.00-6.2], p=0.05). Conclusions We found high symptom prevalence in patients newly diagnosed with inflammatory bowel disease. Three distinct symptom clusters were identified, and the psychological cluster includes >50% of the patients. Vitamin D deficiency is the only factor associated with cluster membership, namely the impaired energy cluster.

• Holten, Kristina Ingeborg; Bernklev, Tomm; Opheim, Randi; Johansen, Ingunn; Olsen, Bjørn Christian Elias Grova & Lund, Charlotte [Show all 22 contributors for this article] (2023). Fatigue in Patients with Newly Diagnosed Inflammatory Bowel Disease: Results from a Prospective Inception Cohort, the IBSEN III Study. Journal of Crohn's and Colitis. ISSN 1873-9946. 17(11), p. 1781–1790. doi: 10.1093/ecco-jcc/jjad094. Full text in Research Archive
• Olsen, Bjørn Christian Elias Grova; Opheim, Randi; Høivik, Marte Lie; Lund, Charlotte; Aabrekk, Tone Bergene & Johansen, Ingunn [Show all 15 contributors for this article] (2023). Health-related quality of life in patients with newly diagnosed inflammatory bowel disease: an observational prospective cohort study (IBSEN III). Quality of Life Research. ISSN 0962-9343. 32(10), p. 2951–2964. doi: 10.1007/s11136-023-03435-9. Full text in Research Archive
• Janson, Astri Letnes; Opheim, Randi & Hellesø, Ragnhild (2023). Advanced practice nurse education in its infancy: an exploratory study of Norwegian higher education institutions’ program descriptions. Scandinavian Journal of Educational Research. ISSN 0031-3831. doi: 10.1080/00313831.2023.2185810.
• Håvi, Gry; Feiring, Eli & Opheim, Randi (2022). «Mer enn bare en håndlanger»: oppfatninger om sykepleierens betydning for kvalitet ved koloskopi. Sykepleien Forskning. ISSN 1890-2936. 17. doi: 10.4220/Sykepleienf.2022.90030.
• Opheim, Randi; Moum, Kristian Marling; Småstuen, Milada Cvancarova & Moum, Bjørn Allan (2022). The impact of restrictions on psychological outcomes in patients with inflammatory bowel disease on biological treatment during the coronavirus pandemic in Norway. Quality of Life Research. ISSN 0962-9343. 20. doi: 10.1007/s11136-022-03254-4. Full text in Research Archive
• Moum, Kristian Marling; Moum, Bjørn & Opheim, Randi (2021). Patients with inflammatory bowel disease on immunosuppressive drugs: perspectives’ on COVID-19 and health care service during the pandemic. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(5), p. 1–8. doi: 10.1080/00365521.2021.1901308. Full text in Research Archive
• Kristensen, Vendel Ailin; Opheim, Randi; Perminow, Gøri Margrete; Huppertz-Hauss, Gert; Detlie, Trond Espen & Lund, Charlotte [Show all 39 contributors for this article] (2021). Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 56(8), p. 899–905. doi: 10.1080/00365521.2021.1922746. Full text in Research Archive Show summary

  Background and aim: Modern treatment strategies for inflammatory bowel disease (IBD) are postulated to change the natural disease course. Inception cohort studies are the gold standard for investigating such changes. We have initiated a new population-based inception cohort study; Inflammatory bowel disease in South Eastern Norway III (IBSEN III). In this article, we describe the study protocol and baseline characteristics of the cohort. Methods: IBSEN III is an ongoing, population-based observational inception cohort study with prospective follow-up. Adult and pediatric patients with suspected IBD in the South-Eastern Health Region of Norway (catchment area of 2.95 million inhabitants in 2017), during the 3-year period from 2017 to 2019, were eligible for inclusion. Comprehensive clinical, biochemical, endoscopic, demographic, and patient-reported data were collected at the time of diagnosis and throughout standardized follow-up. For a portion of the patients, extensive biological material was biobanked. Results: The study included 2168 patients, of whom 1779 were diagnosed with IBD (Crohn's disease: 626, ulcerative colitis: 1082, IBD unclassified: 71). In 124 patients, there were subtle findings indicative of, but not diagnostic for, IBD. The remaining 265 patients were classified as symptomatic non-IBD controls. Conclusion: We have included patients in a comprehensive population-based IBD cohort from a catchment population of 2.95 million, and a unique biobank with materials from newly diagnosed and treatment-naïve IBD patients and symptomatic non-IBD controls. We believe this cohort will add important knowledge about IBD in the years to come.

• Bigum Sundar, Turid Kristin; Riiser, Kirsti; Småstuen, Milada Cvancarova; Opheim, Randi; Løndal, Knut & Glavin, Kari [Show all 7 contributors for this article] (2020). Health-related quality of life among 13–14 year old adolescents with overweight−a mixed methods approach. Health and Quality of Life Outcomes. ISSN 1477-7525. 18, p. 1–10. doi: 10.1186/s12955-020-01413-0. Full text in Research Archive
• Normann, Cathrine Olaussen; Opheim, Randi; Kulle, Bettina; Bernklev, Tomm & Haug, Erik Skaaheim (2020). Health-related quality-of-life after radical cystectomy among Norwegian men and women compared to the general population. Scandinavian Journal of Urology. ISSN 2168-1805. 54(3), p. 181–187. doi: 10.1080/21681805.2020.1754906. Show summary

  Objective: The aim of this study was to assess health-related quality-of-life (HRQoL) in men and women operated on with radical cystectomy, compared to the general Norwegian population. Materials and methods: All patients with bladder cancer who had undergone radical cystectomy (RC) between 2011–2017 and either received ileal conduit (IC) or orthotopic neobladder (ONB) as urinary diversion were included in a cross-sectional study. HRQoL and sociodemographic data was collected and measured with a questionnaire consisting of the generic EORTC QLQ-C30.v3 and the cancer specific EORTC QLQ-BLM30 and compared to a general population sample. Results: Of the 220 invited patients, 173 patients (78.6%) returned the questionnaires. The global quality-of-life (QoL) score was comparable with the general population. Women had significantly higher fatigue score, worse future perspective and symptoms like bloating, compared to male patients. Men had significantly lower social functioning, more constipation, diarrhoea and sleep disturbance compared to the general male population. There was no significant difference in HRQoL domains between female patients and the general female population. A follow-up (FU) period longer than 37 months since surgery was associated with significantly improved physical- and role-functioning, less fatigue and fewer problems with the urostoma, compared to a shorter FU time. Conclusion: This study found a high global QoL score after radical cystectomy, comparable with the general Norwegian population. Symptoms seem to improve over time. Difference in HRQoL outcomes between men and woman in the study population was comparable with the difference found in the general population.

• Opheim, Randi; Moum, Bjørn; Grimstad, Tore; Jahnsen, Jørgen; Berset, Ingrid Prytz & Hovde, Øistein [Show all 9 contributors for this article] (2020). Self-esteem in patients with inflammatory bowel disease. Quality of Life Research. ISSN 0962-9343. 29, p. 1839–1846 . doi: 10.1007/s11136-020-02467-9. Full text in Research Archive Show summary

  Purpose The purpose of this study was to explore self-esteem and associations between self-esteem and sociodemographic, clinical, and psychological factors in patients with infammatory bowel disease (IBD), a disease of chronic relapsing infammation of the gastrointestinal tract. IBD symptoms, including pain, fatigue, and diarrhea, as well as potential life-long medical treatment and surgery, may be demanding, cause signifcant challenges, and infuence self-esteem. Methods In this cross-sectional multicenter study, participants were recruited from nine hospitals in the southeastern and western regions of Norway from March 2013 to April 2014. Data were collected using self-report questionnaires. Selfesteem was assessed by the Rosenberg Self-Esteem Scale, fatigue was assessed by the Fatigue Questionnaire, self-efcacy was assessed by the General Self-Efcacy Scale, and disease activity was assessed by the Simple Clinical Colitis Activity Index for ulcerative colitis (UC) and Harvey Bradshaw Index for Crohn’s disease (CD). Multiple linear regression analysis was applied to examine associations between self-esteem and sociodemographic, clinical, and psychological factors. Results In total, 411 of 452 (91%) patients had evaluable data and were included in this study. The mean scores on selfesteem, self-efcacy, total fatigue, anxiety, and depression were similar between UC patients and CD patients. Male gender, being employed, and higher self-efcacy were independently associated with higher self-esteem, whereas anxiety and depression were independently associated with lower self-esteem. Neither disease activity nor fatigue were associated with self-esteem in the fnal multiple regression analyses. Conclusion Patient-centered interventions that improve self-esteem and reduce anxiety and depression seem to be important to optimize IBD management. Keywords Self-esteem · Self-efcacy · Coping · Infammatory bowel disease · Ulcerative colitis · Crohn’s disease · Health psychology · Chronic disease · Health-related quality of life

• Torres, Joana; Ellul, Pierre; Langhorst, Jost; Mikocka-Walus, Antonina; Barreiro-de Acosta, Manuel & Basnayake, Chamara [Show all 15 contributors for this article] (2019). European Crohn's and colitis organisation topical review on complementary medicine and psychotherapy in inflammatory bowel disease. Journal of Crohn's and Colitis. ISSN 1873-9946. 13(6), p. 673–685e. doi: 10.1093/ecco-jcc/jjz051.
• Lerdal, Anners; Opheim, Randi; Gay, Caryl; Moum, Bjørn; Fagermoen, May Solveig & Kottorp, Anders (2017). Psychometric limitations of the 13-item Sense of Coherence Scale assessed by Rasch analysis. BMC Psychology. ISSN 2050-7283. 5(18). doi: 10.1186/s40359-017-0187-y.
• Huppertz-Hauss, Gert; Høivik, Marte; Jelsness-Jørgensen, Lars-Petter; Opheim, Randi; Henriksen, Magne & Høie, Ole Ingebreth [Show all 13 contributors for this article] (2017). Fatigue in a population-based cohort of patients with inflammatory bowel disease 20 years after diagnosis: The IBSEN study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 52(3), p. 351–358. doi: 10.1080/00365521.2016.1256425.
• Jelsness-Jørgensen, Lars-Petter; Frigstad, Svein Oskar; Moum, Bjørn; Grimstad, Tore; Opheim, Randi & Jahnsen, Jørgen [Show all 7 contributors for this article] (2017). Pain may be an important factor to consider in inflammatory bowel disease patients troubled by fatigue. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 5(5), p. 687–693. doi: 10.1177/2050640616674654.
• Opheim, Randi; Høivik, Marte; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2016). The use of complementary and alternative medicine (CAM) among patients with inflammatory bowel disease (IBD) is associated with reduced health-related quality of life (HRQoL). Gastroenterology Research and Practice. ISSN 1687-6121. 2016. doi: 10.1155/2016/6453657.
• Jelsness-Jørgensen, Lars-Petter; Moum, Bjørn; Grimstad, Tore; Jahnsen, Jørgen; Opheim, Randi & Berset, Ingrid Prytz [Show all 11 contributors for this article] (2016). Validity, reliability, and responsiveness of the brief pain inventory in inflammatory bowel disease. Canadian Journal of Gastroenterology and Hepatology. ISSN 2291-2789. 2016:5624261. doi: 10.1155/2016/5624261.
• Opheim, Randi (2014). Et biopsykososialt perspektiv på abdominale smerter ved inflammatorisk tarmsykdom. Gastroskopet, fagtidsskrift for sykepleiere innen gastroenterologi. Gastroskopet. ISSN 1890-4122. 27(2).
• Opheim, Randi; Fagermoen, May Solveig; Jelsness-Jørgensen, Lars-Petter; Bernklev, Tomm & Moum, Bjørn (2014). Sense of coherence in patients with inflammatory bowel disease. Gastroenterology Research and Practice. ISSN 1687-6121. 2014:989038. doi: 10.1155/2014/989038.
• Opheim, Randi; Fagermoen, May Solveig; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2014). Fatigue interference with daily living among patients with inflammatory bowel disease. Quality of Life Research. ISSN 0962-9343. 23(2), p. 709–719. doi: 10.1007/s11136-013-0508-4.
• Opheim, Randi; Bernklev, Tomm; Fagermoen, May Solveig; Småstuen, Milada C & Moum, Bjørn (2012). Use of complementary and alternative medicine in patients with inflammatory bowel disease: results of a cross-sectional study in Norway. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 47(12), p. 1436–1447. doi: 10.3109/00365521.2012.725092.
• Opheim, Randi; Høivik, Marte; Solberg, Inger Camilla & Moum, Bjørn (2012). Complementary and alternative medicine in patients with inflammatory bowel disease: The results of a population-based inception cohort study (IBSEN). Journal - Crohn's and Colitis Foundation of Canada. ISSN 1197-4982. 6(3), p. 345–353. doi: 10.1016/j.crohns.2011.09.007.

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• Hellesø, Ragnhild & Opheim, Randi (2023). Samhandling i helsetenesta - Sjukepleiarens faglege og organisatoriske rolle. Det Norske Samlaget. ISBN 978-82-340-0311-0. 136 p.

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• Bazov, I.; Kruse, R.; Bergemalm, D.; Eriksson, C.; Hedin, C.R. & van Nieuwenhoven, M. [Show all 28 contributors for this article] (2023). A novel serum protein signature as biomarker for Inflammatory Bowel Disease: A diagnostic performance and prediction modelling study using data from two independent inception cohorts. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, p. i314–i315. doi: 10.1093/ecco-jcc/jjac190.0284.
• Mathisen, Carl Magnus Bache Wiig; Nyström, N.; Bazov, I.; Andersen, S.; Olbjørn, Christine & Perminow, Gøri Margrete [Show all 22 contributors for this article] (2023). A novel diagnostic serum protein signature for paediatric Inflammatory Bowel Disease: A discovery and validation study in two independent inception cohorts. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, p. i71– i71. doi: 10.1093/ecco-jcc/jjac190.0051.
• Janson, Astri Letnes; Opheim, Randi & Hellesø, Ragnhild (2023). Applying document analysis in nursing research – possibilities for understanding advanced practice nurse education.
• Hansen, Simen Hyll; Gjerstad Maseng, M; Bjørkqvist, O; Halfvarsson, J; Bang, C & Detlie, Trond Espen [Show all 23 contributors for this article] (2023). Gut microbiota at diagnosis is associated with clinical features and future disease course in Inflammatory Bowel Disease: Data from IBSEN III, a new large Norwegian population-based inception cohort. Journal of Crohn's and Colitis. ISSN 1873-9946. 17, p. i1028–I2029. doi: 10.1093/ecco-jcc/jjac190.1050.
• Zerouga, Insaf; Sommer, Christine; Carlsen, Monica Hauger; Valeur, Jørgen; Kristensen, Vendel Ailin & Høivik, Marte Lie [Show all 8 contributors for this article] (2023). Kosthold og ernæringsstatus ved nydiagostisert IBD: resultater fra IBSEN III.
• Johansen, Ingunn; Småstuen, Milada Cvancarova; Løkkeberg, Stine Eileen Torp; Kristensen, Vendel Ailin; Høivik, Marte Lie & Lund, Charlotte [Show all 16 contributors for this article] (2022). Symptoms and symptom clusters in patients newly diagnosed with inflammtory bowel disease – results from the IBSEN III study .
• Strande, Vibeke; Småstuen, Milada C.; Lund, Charlotte; Bengtson, May-Bente; Høie, Ole & Boyar Cetinkaya, Raziye [Show all 26 contributors for this article] (2022). Klinisk karakteristika hos nydiagnostiserte pasienter med inflammatorisk tarmsykdom - resultater fra IBSEN III-studien.
• Strande, Vibeke; Småstuen, Milada C; Huppertz-Hauss, Gert; Perminow, Gøri ; Henriksen, Magne & Bengtson, May-Bente [Show all 17 contributors for this article] (2022). Fecal calprotectin at diagnosis is associated with oral steroid use first year of inflammatory bowel disease.
• Janson, Astri Letnes; Opheim, Randi & Hellesø, Ragnhild (2021). Kliniske masterutdanninger for sykepleiere. Kompetanseheving for primærhelsetjenesten?
• Strande, Vibeke; Småstuen, Milada C.; Hasund, Audun; Huppertz-Hauss, Gert; Pallenschat, Jens & Bengtson, May-Bente [Show all 18 contributors for this article] (2021). Clinical characteristics associated with biochemical remission three months after diagnosis of Crohn's disease.
• Strande, Vibeke; Småstuen, Milada C.; Hasund, Audun; Huppertz-Hauss, Gert; Pallenschat, Jens & Bengtson, May-Bente [Show all 18 contributors for this article] (2021). Clinical characteristics associated with biochemical remission three months after diagnosis of ulcerative colitis.
• Kristensen, Vendel Ailin; Lund, Charlotte; Opheim, Randi; Ricanek, Petr; Huppertz-Hauss, Gert & Perminow, Gøri Margrete [Show all 37 contributors for this article] (2020). Inflammatory Bowel Disease in South-Eastern Norway III – IBSEN III.
• Reime, Marit Hegg & Opheim, Randi (2019). Sykepleie til pasienter med fordøyelsessykdom. In Knutstad, Unni (Eds.), Utøvelse av klinisk sykepleie. Sykepleieboken 3. Cappelen Damm Akademisk. ISSN 9788202543099. p. 278–383.
• Opheim, Randi; Jahnsen, Jørgen; Bernklev, Tomm; Høie, Ole Ingebreth; Huppertz-Hauss, Gert & Moum, Bjørn (2019). Complementary and alternative medicine in patients with inflammatory bowel disease 20 years after diagnosis: Results from the IBSEN study. American Journal of Gastroenterology. ISSN 0002-9270. 114, p. S12–S13. doi: 10.14309/01.ajg.0000578256.56976.23.
• Opheim, Randi (2018). Psykososial helse blant barn og ungdom med inflammatorisk tarmsykdom - en populasjonsbasert prospektiv observasjonsstudie - IBSEN III studien.
• Opheim, Randi (2018). Complementary and alterantive therapies in inflammatory bowel disease.
• Opheim, Randi; Bernklev, Tomm; Jahnsen, Jørgen; Grimstad, Tore; Hovde, Øistein & Berset, Ingrid Prytz [Show all 8 contributors for this article] (2018). Chronic fatigue in patients with inflammatory bowel disease is associated with lower health–related quality of life, low self-esteem, increased anxiety and depression.
• Kristensen, Vendel Ailin; Opheim, Randi; Ricanek, Petr; Detlie, Trond Espen; Perminow, Gøri Margrete & Høivik, Marte Lie (2018). IBSEN III—a new population-based inception cohort from South-Eastern Norway.
• Opheim, Randi (2018). Complementary therapies in IBD.
• Opheim, Randi (2017). Psychosocial health and health-related quality of life in children and adolescents with IBD - an overview of the literature. .
• Opheim, Randi (2017). “Measurement of conditions”. .
• Bernklev, Tomm; Huppertz-Hauss, Gert; Opheim, Randi; Høivik, Marte; Moum, Bjørn & Jelsness-Jørgensen, Lars-Petter [Show all 7 contributors for this article] (2016). Co-existing Irritable Bowel Syndrome (IBS) in Inflammatory Bowel Disease (IBD) is associated with increased risk of chronic fatigue (CF), especially in females.
• Opheim, Randi (2015). Hver tredje pasient med inflammatorisk tarmsykdom oppsøker alternativ behandler. Best Practice Gastroenterology.
• Jelsness-Jørgensen, Lars-Petter; Lie Høivik, Marte; Moum, Bjørn; Opheim, Randi; Huppertz-Hauss, Gert & Grimstad, Tore [Show all 10 contributors for this article] (2015). Fatigue is associated with increased pain intensity and interference in IBD. Inflammatory Bowel Diseases. ISSN 1078-0998. doi: 10.1080/00365521.
• Opheim, Randi; Høivik Lie, Marte; Bernklev, Tomm; Jelsness-Jørgensen, Lars-Petter & Moum, Bjørn (2015). Relationship between use of complementary and alternative medicine (CAM) and health-related quality of life (HRQoL) among patients with inflammatory bowel disease. Journal of Crohn’s and Coltis Supplements. ISSN 1873-9954. 9.
• Bernklev, Tomm; Huppertz-Hauss, Gert; Jelsness-Jørgensen, Lars-Petter; Høivik, Marte; Opheim, Randi & Jahnsen, Jørgen [Show all 7 contributors for this article] (2014). Chronic Fatigue Twenty Years After Diagnosis. Results from the IBSEN-Study. Inflammatory Bowel Diseases. ISSN 1078-0998. 20(12), p. 31–32. doi: 10.1097/01.MIB.0000456782.03905.38.
• Opheim, Randi (2012). “Bruk av komplementær og alternativ medisin blant pasienter med inflammatoriske tarmsykdommer”.
• Opheim, Randi (2010). Complementary and alternative medicine among patients with Inflammatory Bowel Disease. Classification criteria determine level of use.
• Antonsen, Anniken; Opheim, Randi; Schnierer, Martin; Bernklev, Tomm; Hyrdel, Rudolf & Moum, Bjørn (2010). Use of complementary and alternative medicine in Inflammatory bowel disease. Results from a hospital based registry in Slovakia. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 45, p. 51–51.

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