Ishaq, Bushra
(2021).
Islamsk tro og helse.
I Botten, Grete Synøve (Red.),
Mangfold og engasjement i ti år. Institutt for helse og samfunn ved Universitetet i Oslo 2010-2020..
Norwegian Medical Society.
ISSN 978-82-92871-76-8.s. 141–147.Fulltekst i vitenarkiv
Ishaq, Bushra
(2020).
Lidelse og mening i islamske tradisjoner - fra et klinisk perspektiv .
I Austad, Anne; Borge, Lisbet; Leenderts, Torborg Aalen; Stifoss-Hanssen, Hans & Thomassen, Magdalene (Red.),
Lidelse mening og livssyn : teori og praksis.
Fagbokforlaget.
ISSN 9788245024098.s. 123–135.
Aims: Gene therapy of a peripheral organ to protect the heart is clinically attractive. The transcription factor hypoxia-inducible factor 1 alpha (HIF-1 alpha) transactivates cardioprotective genes. We investigated if remote delivery of DNA encoding for HIF-1 alpha is protective against myocardial ischemia-reperfusion injury in vivo.
Main methods: DNA encoding for human HIF-1 alpha was delivered to quadriceps muscles of mice. One week later myocardial infarction was induced and four weeks later its size was measured. Echocardiography and in vivo pressure-volume analysis was performed. Coronary vascularization was evaluated through plastic casting. HL-1 cells, transfected with either HIF-1 alpha or HMOX-1 or administered bilirubin or the carbon monoxide (CO) donor CORM-2, were subjected to lipopolysacharide (LPS)-induced cell death to compare the efficacy of treatments.
Key findings: After four weeks of reperfusion post infarction, animals pretreated with HIF-1 alpha showed reduced infarct size and left ventricular remodeling (p<0.05, respectively). Fractional shortening was preserved in mice pretreated with HIF-1 alpha (p<0.05). Invasive hemodynamic parameters indicated preserved left ventricular function after HIF-1 alpha (p<0.05), which also induced coronary vascularization (p<0.05). HIF-1 alpha downstream target heme oxygenase 1 (HMOX-1) was upregulated in skeletal muscle, while serum bilirubin was increased. Transfection of HL-1 cells with HIF-1 alpha or HMOX-1 and administration of bilirubin or CORM-2 comparably salvaged cells from lipopolysacharide (LPS)-induced cell death (all p<0.05).
Significance: HIF-1 alpha gene delivery to skeletal muscle preceding myocardial ischemia reduced infarct size and postischemic remodeling accompanied by an improved cardiac function and vascularization. Similar to HIF-1 alpha, HMOX-1, bilirubin and CO were protective against LPS-induced injury. This observation may have clinical potential. (C) 2011 Elsevier Inc. All rights reserved.
Czibik, Gabor Tamas; Gravning, JA; Martinov, VN; Ishaq, Bushra; Attramadal, Håvard & Valen, Guro
(2011).
Remote delivery of DNA encoding for hypoxia-inducible factor 1 alpha is protective against in vivo myocardial ischemia-reperfusion injury.
Life Sciences.
ISSN 0024-3205.
16,
s. 71–78.
Czibik, Gabor Tamas; Sagave, Julia Fritzi; Martinov, Vladimir Nikolkaev; Ishaq, Bushra; Sohl, M & Sefland, Iren
[Vis alle 10 forfattere av denne artikkelen](2009).
Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice.
Cardiovascular Research (CVR).
ISSN 0008-6363.
82(1),
s. 107–114.
doi: 10.1093/cvr/cvp035.
Korte innlegg fra inviterte innledere, etterfulgt av dialog/panel.
Bushra Ishaq (assisterende bydelsoverlege, forsker og skribent) ; Esperanza Diaz (lege og professor, leder av Pandemisenteret v/Universitetet i Bergen) ; Sandra Oliveira e Costa og Hjördis Rut Sigurjonsdottir (forskere, Nordregio - Sverige) ; Thor Indseth (avdelingsdirektør, område for helsetjenester, Folkehelseinstituttet). Møteledere: Avdelingsdirektør Øyvind Giæver og fagrådsleder Hege Linnestad
Ishaq, Bushra
(2021).
Ulikhet i helse, og Coronapandemien.
Ishaq, Bushra
(2024).
Determinants of health among Muslims in Norway : Muslim religiosity and perceived discrimination among Muslims in Norway - impacts on health and health behaviour.
MF vitenskapelig høyskole.
Ishaq, Bushra; Tyssvang, Marius & Høiland, Tor Erik
(2021).
Kartlegging av uvaksinerte innbyggere i Bydel Alna i aldersgruppen 65-74 år: Notat.
Oslo kommune, bydel Alna.