Espen Saxhaug Kristoffersen

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English version of this page

E-post e.s.kristoffersen@medisin.uio.no

Mobiltelefon +47 97665483

Brukernavn

Besøksadresse Kirkeveien 166 Fredrik Holsts hus 0450 Oslo

Postadresse Postboks 1130 Blindern 0318 Oslo

Pressebilde Last ned visittkort

ORCID: 0000-0002-8999-5424

Researchgate

Academic interests

Ischemic stroke and intracerebral hemorrhage incl. epidemiology, prevention, acute treatment, imaging and prediction
Headache/migraine/cluster headache incl. epidemiology, treatment effects, cardiovascular risk, biomarkers, genetics, epigenetics and imaging
Cerebral Venous Thrombosis (epidemiology, risk factors, treatment and long-term prognosis
General Practice/Neurology
Mountain medicine, wilderness medicine, rescue medicine

Education/background

2022 to present: Part of Norwegian Research Centre for Headache NorHEAD, Norway
2019 to present: Senior consultant, Stroke Unit and Department of Neurology, Akershus University Hospital (Ahus), Norway
2017 to present: Associate professor, Department of General Practice, University of Oslo, Norway
2018-2022: Leader Work Package 2, Recruitment and Research of PraksisNett, a research infrastructure funded by Norwegian Research Council and the University of Oslo, Norway
2014-2017: Postdoctoral fellow, Department of General Practice, University of Oslo
2013-2019: resident, Department of Neurology, Akershus University Hospital
2014: Ph.d with the thesis “Brief Intervention for Medication-overuse headache in primary care”
2008-2014: PhD student - Department of General Practice, University of Oslo
2011: part-time at the central primary care emergency ward in Oslo
2010: General practitioner (part-time) in the municipality of Høyanger
2007-08: General practitioner and chief medical officer in the municipality of Høyanger
2005-07: Intern at Department of Medicine, Orthopedics and Surgery at Helse Førde hospital (Nordfjord/Førde) and the municipality of Balestrand
2004-05: Six months as resident doctor with students licentia practicandi at the Acute psychiatric ward, the University Hospital of Northern Norway (UNN)
2004 Medical students mandatory practice period at Longyearbyen Hospital, Svalbard 3 months
2003 Medical students mandatory practice period at Internal Medicine and Surgery, Hammerfest Hospital 2+2 months
2005: Medical degree (MD) University of Tromsø
1999-2005: Medical school, University Of Tromsø

Positions held

2024 to preset: European Stroke Organisation Working group for new guideline for PRES and RCVS
2022 to present: European Academy of Neurology Working group for new guideline for migraine treatment
2019 to present: Member of the Special Interest Group of Secondary headaches, International Headache Society (IHS)
2019 to present: Responsible for the eBrain interactive learning course on migraine and trigeminal autonomic cephalalgias for the European Academy of Neurology
2016 to present: Member of European Academy of Neurology (EAN) Scientific Panel Headache
2020-2023: Board member of the Nansen Neuroscience Network, NO
2019-2023: Member of the Reference group at the Norwegian Advisory Unit on Headache, St. Olav's Hospital, Trondheim, Norway.
2019-2022: Member of the Education Committee of the International Headache Society (IHS)
2018-2022: Norwegian representative International Headache Society and European Headache Federation
2017-2021: Board member and vice-chair of the Norwegian Headache Society
2014-2021: Board member of the International Headache Society (IHS) Trainees and Residents Special Interest Group
2013-2014: Member of the group “AG4 – kommunesektoren” in the national strategy process ”HelseOmsorg21”.
2012-13: Member of the project group within the Norwegian Medical Association (representing the College of General Practice), working with the plan for further
development of the Norwegian list patient system (“Opptrappingsplan for fastlegeordningen 2015-2020”).
2012-2013: Board member of Oslo Legeforening (the largest local part of the Norwegian Medical Association)
2011-2015: Board member of LVS (Doctors in Scientific Positions) at the Norwegian Medial Association
2011-2015: Founding member of the Project Group (ALIS-utvalget) within the Norwegian College of General Practice, working with recruitment schemes for younger doctors into primary care
2010-12: Board member of the PhD forum at HELSAM (The institute of general practice and public health) , University of Oslo
2009-2016: Member of the Network Group for Out-Of-Hours Services at Norwegian College of General Practice (part of the Norwegian Medical Association)

Awards

European Academy of Neurology (EAN) Investigator Award for the subspecialty Headache - 1st EAN Congress Berlin, Germany June 2015
Norwegian Neurological Federation - National Headache fellowship 2018
Best poster presentation at the Norwegian Neurology Congress 2018
Forsberg og Aulies legat 2018
Norwegian Neurological Federation – National Neurology Fellowship 2020

Project management experience (Project leader)

Completed studies

2013-2017 Long-term follow-up of a Brief intervention for Medication Overuse Headache – in primary care (own post.doc, funded by University of Oslo)
2016-2018 Neurology residents’ knowledge of the management of headache
2016-2019 Norwegian GPs experience and training in handling of headache patients
2020 Stroke during a pandemic (StrokePan)
2020 Neurology during a pandemic (NeuroPan)

Ongoing studies

2017- The Akershus aCute Headache Evaluation 1 (ACHE-1) study. Epidemiology, clinical presentation, treatment and follow-up of subarachnoid haemorrhage in a Norwegian population
2017- The Akershus Study of Ischemic Stroke and Thrombolysis 1 (ASIST-1)
2018- The Akershus Cerebellar Haemorrhage Evaluation study (ACHE-3)
2018- Epidemiology, clinical and radiological presentation and prognosis of cerebral venous thrombosis in a Norwegian population (NoCVT)
2019 - Job satisfaction, career and burn-out among neurologists in Norway
2020- Secondary prevention in Stroke - a nationwide register-linked prospective follow-up study in general practice
2020 - Intracerebral Haemorrhage in a Norwegian population - a prospective long-term follow-up study
2021- Exploring the biology, treatment and prognosis of cerebral venous thrombosis

Major International collaborations (all on-going)

2016 - HUNT All-In project Headache
2016 - International Cluster Headache Genetics Consortium
2018 - Different research projects on migraine, telemedicine, cluster headache, headache education, GPs handling of headache and medication-overuse headache with Danish Headache Centre, DK
2019 - HUNT All-In project Cerebrovascular diseases
2019 - International Migraine Genetics Consortium
2019 - International Headache Society Secondary headaches projects
2020 - The Global COVID-19 Stroke Registry led by Raul Nogueira and Thanh Nguyen, US
2021 - International Cerebral Venous Thrombosis Consortium
2021 - The Global COVID-19 CVT Registry led by Thanh Nguyen, US
2021 - International CVT consortium post-vaccine study led by Jonathan Couthino, Netherland
2021 - CVT-AIM (CVT and Autoimmune diseases), led by Dr. Sini Hiltunen, Helsinki, Finland
2022 - DOAC-IVT, led by David Seiffge, Bern, Switzerland
2022 - ICEBERG project, led by Bradley MacIntosh, Toronto, Canada
2023 - READOUT-ICH, led by Bradley MacIntosh, Toronto, Canada
2023 - Several projects in collaboration with David Seiffge and Thomas Meinel, Bern, Switzerland
International treatment studies (investigator-initiated):
National leader ExCOA-CVT (treatment study of CVT), led by prof. Jóse Ferro, Lisbon, Portugal
National leader DOAC-CVT (treatment study of DOAC in CVT), led by prof. Jonathan Couthino, Amsterdam, Netherland
PI at Akershus University Hospital- Biofeedback for migraine (BioCer) RCT, led by Tore Meisingset, St.Olavs, Norway
PI at Akershus University Hospital – ELAN study, led by prof. Urs Fischer, Bern, Switzerland (completed)

Courses taught

2021- Headache Master Programme, Danish Headache Centre, University of Copenhagen, DK
2020- Censorship Headache Master Programme, Danish Headache Centre, University of Copenhagen, DK
2008-to present: Teaching and censorship in various terms (including final exams) in Medical School at the University of Oslo, NO
2008-to present: 5-10 yearly invited lectures for Norwegian neurology and GPs in training as a part of their educational activity to become certified specialists, NO
2019-2021: Teaching and lectures in final neurology term in Medical School at the University of Tromsø, Finmarksmodellen, NO
2010-12: Various lectures held twice a year at the Oslo Emergency ward for the doctors there as a part of their educational activity, NO
2010-12: Teaching CME groups about headache, NO
2010-12: Project and course leader for a CME course called Management of chronic headache in primary care – course held 11 times (15 hours each course)

Qu, Kang; Li, Ming-Xi; Yu, Peng; Wu, Bai-Hua; Shi, Miao & Dong, Ming [Vis alle 72 forfattere av denne artikkelen] (2024). HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study. Scientific Reports. ISSN 2045-2322. 14(1). doi: 10.1038/s41598-024-61628-9.
Scutelnic, Adrian; van de Munckhof, Anita; Miraclin, Angel T.; Aaron, Sanjith; Hameed, Sajid & Wasay, Mohammad [Vis alle 46 forfattere av denne artikkelen] (2024). Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19. European Stroke Journal. ISSN 2396-9873. doi: 10.1177/23969873241241885.
Kristoffersen, Espen Saxhaug; Waage, Siri; Pallesen, Staale & Bjorvatn, Bjørn (2024). Changes in work schedule affect headache frequency among Norwegian nurses: A 3-year-follow-up study. Occupational and Environmental Medicine. ISSN 1351-0711. doi: 10.1136/oemed-2023-109164.
Mitsikostas, Dimos-Dimtirios D.; Caronna, Edoardo; De Tommaso, Marina; Deligianni, Christina I.; Ekizoglu, Esme & Bolay, Hayrunnisa [Vis alle 14 forfattere av denne artikkelen] (2024). Headaches and facial pain attributed to SARS-CoV-2 infection and vaccination: a systematic review. European Journal of Neurology. ISSN 1351-5101. doi: 10.1111/ene.16251.
Siepen, Bernhard M.; Forfang, Elisabeth; Branca, Mattia; Drop, Boudewijn; Mueller, Madlaine & Goeldlin, Martina B. [Vis alle 36 forfattere av denne artikkelen] (2024). Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries. Stroke and Vascular Neurology. ISSN 2059-8688. doi: 10.1136/svn-2023-002813.
Bjelkarøy, Maria Torheim; Simonsen, Tone Breines; Siddiqui, Tahreem Ghazal; Halset, Sigrid; Cheng, Socheat & Grambaite, Ramune [Vis alle 10 forfattere av denne artikkelen] (2024). Brief Intervention as a Method to Reduce Z-Hypnotic Use by Older Adults: Feasibility Case Series. JMIR Formative Research. ISSN 2561-326X. 8(1). doi: 10.2196/51862. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Pallesen, Ståle; Waage, Siri & Bjorvatn, Bjørn (2024). The long-term effect of work schedule, shift work disorder, insomnia and restless legs syndrome on headache among nurses: A prospective longitudinal cohort study. Cephalalgia. ISSN 0333-1024. 44(1). doi: 10.1177/03331024231226323.
Van De Munckhof, Anita; Borhani-Haghighi, Afshin; Aaron, Sanjith; Krzywicka, Katarzyna; Sánchez van Kammen, Mayte & Cordonnier, Charlotte [Vis alle 48 forfattere av denne artikkelen] (2023). Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries. International Journal of Stroke. ISSN 1747-4930. 18(9), s. 1112–1120. doi: 10.1177/17474930231182901.
Ken-Dror, Gie; Sharma, Pankaj; Kristoffersen, Espen Saxhaug & Study Group, CVT VITT (2023). ABO blood group associated with cerebral venous thrombosis after Oxford-AstraZeneca COVID-19 vaccination: a case-control study. Journal of the Royal Society of Medicine. ISSN 0141-0768. doi: 10.1177/01410768231214341. Fulltekst i vitenarkiv
Strambo, Davide; Marto, João Pedro; Ntaios, George; Nguyen, Thanh N; Michel, Patrik & Herzig, Roman [Vis alle 51 forfattere av denne artikkelen] (2023). Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes. Stroke. ISSN 0039-2499. 55(1), s. 78–88. doi: 10.1161/STROKEAHA.123.043899. Fulltekst i vitenarkiv
Scutelnic, Adrian; van de Munckhof, Anita; Krzywicka, Katarzyna; van Kammen, Mayte Sánchez; Lindgren, Erik & Cordonnier, Charlotte [Vis alle 186 forfattere av denne artikkelen] (2023). Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19. European Stroke Journal. ISSN 2396-9873. 8(4), s. 1001–1010. doi: 10.1177/23969873231185213.
Jacobsen, Kaya Kvarme; Børte, Sigrid; Laborie, Lene Bjerke; Kristiansen, Hege; Schäfer, Annette & Martinsen, Amy [Vis alle 30 forfattere av denne artikkelen] (2023). COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study. Osteoarthritis and Cartilage Open. ISSN 2665-9131. 6(1), s. 1–7. doi: 10.1016/j.ocarto.2023.100424. Fulltekst i vitenarkiv Vis sammendrag
Objective: Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30% of all total hip arthroplasties (THAs) in adults <40 years of age and can result in loss of life quality. Our aim was to explore the genetic background of DDH in order to improve diagnosis, management and longterm outcome. Design: We used the large, ongoing, longitudinal Trøndelag Health Study (HUNT) database. Case definition was based on ICD-9/-10 diagnoses of DDH, or osteoarthritis secondary to DDH. Analyses were performed using SAIGE software, with covariates including sex, batch, birth year and principal components. We included only single nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) 0.01, R2 0.8 and Hardy-Weinberg equilibrium (HWE) P-value 0.0001. Significance level was set at p < 5x10-8. Meta-analysis using data from DDH and primary osteoarthritis genome-wide association studies (GWASs) was done using METAL software. The study was approved by the regional ethical committee. Results: Analysis included 69,500 individuals, of which 408 cases, and 8,531,386 SNPs. Two SNPs near COL11A1 were significantly associated with DDH; rs713162 ( = -0.43, SE = 0.07, p = 8.4x10-9) and rs6577334 ( = -0.43, SE = 0.08, p = 8.9x10-9). COL11A1 has previously been associated with acetabular dysplasia and osteoarthritis. Meta-analysis supported previous GWAS findings of both DDH and primary osteoarthritis. Conclusions: This large, genome-wide case-control study indicates an association between COL11A1 and DDH and is an important contribution to investigating the etiology of DDH, with further research needed.
Bjelkarøy, Maria Torheim; Saltyte Benth, Jurate; Simonsen, Tone Breines; Siddiqui, Tahreem Ghazal; Cheng, Socheat & Kristoffersen, Espen Saxhaug [Vis alle 7 forfattere av denne artikkelen] (2023). Measuring pain intensity in older adults. Can the visual analogue scale and the numeric rating scale be used interchangeably? Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 130. doi: 10.1016/j.pnpbp.2023.110925. Fulltekst i vitenarkiv
van de Munckhof, Anita; Sánchez van Kammen, Mayte; Krzywicka, Katarzyna; Aaron, Sanjith; Aguiar de Sousa, Diana & Antochi, Florina [Vis alle 31 forfattere av denne artikkelen] (2023). Direct oral anticoagulants for the treatment of cerebral venous thrombosis – a protocol of an international phase IV study. Frontiers in Neurology. ISSN 1664-2295. 14. doi: 10.3389/fneur.2023.1251581.
Fischer, Urs; Koga, Masatoshi; Strbian, Daniel; Branca, Mattia; Abend, Stefanie & Trelle, Sven [Vis alle 65 forfattere av denne artikkelen] (2023). Early versus Later Anticoagulation for Stroke with Atrial Fibrillation. New England Journal of Medicine. ISSN 0028-4793. 388(26), s. 2411–2421. doi: 10.1056/NEJMoa2303048. Fulltekst i vitenarkiv
MacIntosh, Bradley; Liu, Qinghui; SCHELLHORN, TILL; Beyer, Mona K.; Groote, Inge Rasmus & Morberg, Pål [Vis alle 20 forfattere av denne artikkelen] (2023). Radiological features of brain hemorrhage through automated segmentation from computed tomography in stroke and traumatic brain injury. Frontiers in Neurology. ISSN 1664-2295. 14. doi: 10.3389/fneur.2023.1244672. Fulltekst i vitenarkiv
Winsvold, Bendik Kristoffer Slagsvold; Harder, Aster V. E.; Ran, Caroline; Chalmer, Mona A.; Dalmasso, Maria Carolina & Ferkingstad, Egil [Vis alle 93 forfattere av denne artikkelen] (2023). Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor. Annals of Neurology. ISSN 0364-5134. 94(4), s. 713–726. doi: 10.1002/ana.26743. Fulltekst i vitenarkiv
Klein, Piers; Huo, Xiaochuan; Chen, Yimin; Abdalkader, Mohamad; Qiu, Zhongming & Nagel, Simon [Vis alle 76 forfattere av denne artikkelen] (2023). Specialist Perspectives on the Imaging Selection of Large Vessel Occlusion in the Late Window. Clinical Neuroradiology. ISSN 1869-1439. 33(3), s. 801–811. doi: 10.1007/s00062-023-01284-0.
Krzywicka, Katarzyna; Aguiar de Sousa, Diana; Cordonnier, Charlotte; Bode, Felix J.; Field, Thalia S. & Michalski, Dominik [Vis alle 52 forfattere av denne artikkelen] (2023). Decompressive surgery in cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia. European Journal of Neurology. ISSN 1351-5101. 30(5), s. 1335–1345. doi: 10.1111/ene.15735. Fulltekst i vitenarkiv
Edwards, Christopher; Drumm, Brian; Siegler, James E.; Schonewille, Wouter J.; Klein, Piers & Huo, Xiaochuan [Vis alle 58 forfattere av denne artikkelen] (2023). Basilar artery occlusion management: Specialist perspectives from an international survey. Journal of Neuroimaging (JON). ISSN 1051-2284. 33(3), s. 422–433. doi: 10.1111/jon.13084.
Larsen, Kristin Tveitan; Sandset, Else Charlotte; Selseth, Maiken Nordahl; Jahr, Silje Holt; Koubaa, Nojoud & Hillestad, Vigdis [Vis alle 8 forfattere av denne artikkelen] (2023). Antithrombotic Treatment, Prehospital Blood Pressure, and Outcomes in Spontaneous Intracerebral Hemorrhage. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 12(5), s. 1–12. doi: 10.1161/JAHA.122.028336. Fulltekst i vitenarkiv
Meinel, Thomas R.; Wilson, Duncan; Gensicke, Henrik; Scheitz, Jan F.; Ringleb, Peter & Goganau, Ioana [Vis alle 50 forfattere av denne artikkelen] (2023). Intravenous thrombolysis in patients with ischemic stroke and recent ingestion of direct oral anticoagulants. JAMA Neurology. ISSN 2168-6149. 80(3), s. 233–243. doi: 10.1001/jamaneurol.2022.4782.
Nguyen, Thanh; Qureshi, Muhammad M.; Klein, Piers; Yamagami, Hiroshi; Mikulik, Robert & Czlonkowska, Anna [Vis alle 50 forfattere av denne artikkelen] (2022). Global Effect of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events A 1-Year Follow-up. Neurology. ISSN 0028-3878. 100(4), s. e408–e421. doi: 10.1212/WNL.0000000000201426. Fulltekst i vitenarkiv
Marto, João Pedro; Strambo, Davide; Ntaios, George; Nguyen, Thanh; Herzig, Roman & Czlonkowska, Anna [Vis alle 46 forfattere av denne artikkelen] (2022). Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry. Neurology. ISSN 0028-3878. 100(7), s. e739–e750. doi: 10.1212/WNL.0000000000201537. Fulltekst i vitenarkiv
Hautakangas, Heidi; Winsvold, Bendik K S; Ruotsalainen, Sanni; Bjornsdottir, Gyda; Harder, Aster V. E. & Kogelman, Lisette J. A. [Vis alle 50 forfattere av denne artikkelen] (2022). Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles . Nature Genetics. ISSN 1061-4036. 54, s. 152–160. doi: 10.1038/s41588-021-00990-0. Fulltekst i vitenarkiv
Klein, Piers; Herning, Ana; Drumm, Brian; Raymond, Jean; Abdalkader, Mohamad & Siegler, James E. [Vis alle 56 forfattere av denne artikkelen] (2022). Basilar Artery Occlusion Thrombectomy Technique: An International Survey of Practice Patterns. Stroke: Vascular and Interventional Neurology. ISSN 2694-5746. s. 1–10. doi: 10.1161/SVIN.122.000642. Fulltekst i vitenarkiv
Drumm, Brian; Banerjee, Soma; Qureshi, Muhammad M.; Schonewille, Wouter J.; Klein, Piers & Huo, Xiaochuan [Vis alle 48 forfattere av denne artikkelen] (2022). Current Opinions on Optimal Management of Basilar Artery Occlusion: After the BEST of BASICS Survey. Stroke: Vascular and Interventional Neurology. ISSN 2694-5746. 2(5), s. 1–14. doi: 10.1161/SVIN.122.000538. Fulltekst i vitenarkiv
Nguyen, Thanh; Klein, Piers; Berberich, Anne; Nagel, Simon; Abdalkader, Mohamad & Herning, Ana [Vis alle 66 forfattere av denne artikkelen] (2022). Late Window Imaging Selection for Endovascular Therapy of Large Vessel Occlusion Stroke: An International Survey. Stroke: Vascular and Interventional Neurology. ISSN 2694-5746. 3(1), s. 1–15. doi: 10.1161/SVIN.122.000595. Fulltekst i vitenarkiv
Carlsen, Louise Ninett; Stefansen, Simon; Ahnfeldt-Mollerup, Peder; Jensen, Rigmor H; Kristoffersen, Espen Saxhaug & Hansen, Jakob Møller [Vis alle 7 forfattere av denne artikkelen] (2022). Diagnostics and management of headache in general practice. Family Practice. ISSN 0263-2136. doi: 10.1093/fampra/cmac121.
Drumm, Brian; Herning, Ana; Klein, Piers; Raymond, Jean; Abdalkader, Mohamad & Huo, Xiaochuan [Vis alle 65 forfattere av denne artikkelen] (2022). Basilar artery occlusion management: An international survey of middle versus high-income countries. Interventional Neuroradiology. ISSN 1591-0199. s. 1–10. doi: 10.1177/15910199221143190.
Larsen, Kristin Tveitan; Selseth, Maiken Nordahl; Jahr, Silje Holt; Hillestad, Vigdis; Koubaa, Nojoud & Sandset, Else Charlotte [Vis alle 8 forfattere av denne artikkelen] (2022). Prehospital Blood Pressure and Clinical and Radiological Outcomes in Acute Spontaneous Intracerebral Hemorrhage. Stroke. ISSN 0039-2499. 53(12), s. 3633–3641. doi: 10.1161/STROKEAHA.121.038524.
Nguyen, Thanh N.; Qureshi, Muhammad M.; Klein, Piers; Yamagami, Hiroshi; Abdalkader, Mohamad & Mikulik, Robert [Vis alle 269 forfattere av denne artikkelen] (2022). Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality. Journal of Stroke (JOS). ISSN 2287-6391. 24(2), s. 256–265. doi: 10.5853/jos.2022.00752. Fulltekst i vitenarkiv
Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi & Posner, Daniel C. [Vis alle 203 forfattere av denne artikkelen] (2022). Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. ISSN 0028-0836. 611(7934). doi: 10.1038/s41586-022-05165-3. Fulltekst i vitenarkiv
Huo, Xiaochuan; Klein, Piers; Raynald, NN.; Drumm, Brian; Chen, Yimin & Qureshi, Muhammad M. [Vis alle 45 forfattere av denne artikkelen] (2022). Perceptions on basilar artery occlusion management in China versus other countries: Analysis of the after the BEST of BASICS (ABBA) survey. Journal of Stroke & Cerebrovascular Diseases. ISSN 1052-3057. 31(11). doi: 10.1016/j.jstrokecerebrovasdis.2022.106804.
Yang, Min; Cheng, Hang; Wang, Xia; Ouyang, Menglu; Shajahan, Sultana & Carcel, Cheryl [Vis alle 12 forfattere av denne artikkelen] (2022). Antithrombotics prescription and adherence among stroke survivors: A systematic review and meta-analysis. Brain and Behavior. ISSN 2162-3279. 12(10), s. 1–15. doi: 10.1002/brb3.2752. Fulltekst i vitenarkiv
Nguyen, Thanh N; Qureshi, Muhammad M; Klein, Piers; Yamagami, Hiroshi; Mikulik, Robert & Etminan, Nima [Vis alle 275 forfattere av denne artikkelen] (2022). Global impact of the COVID-19 pandemic on subarachnoid haemorrhage hospitalisations, aneurysm treatment and in-hospital mortality: 1-year follow-up. Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050. 93(10), s. 1028–1038. doi: 10.1136/jnnp-2022-329200.
Clausen, Tobias Christian; Greve, Nikolaos Kalogeropoulos; Müller, Kai Ivar; Kristoffersen, Espen Saxhaug & Schytz, Henrik Winther (2022). Telemedicine in headache care: A systematic review. Cephalalgia. ISSN 0333-1024. 42(13), s. 1397–1408. doi: 10.1177/03331024221111554.
Scutelnic, Adrian; Krzywicka, Katarzyna; Mbroh, Joshua; van de Munckhof, Anita; van Kammen, Mayte Sánchez & de Sousa, Diana Aguiar [Vis alle 105 forfattere av denne artikkelen] (2022). Management of Cerebral Venous Thrombosis Due to Adenoviral COVID-19 Vaccination. Annals of Neurology. ISSN 0364-5134. 92(4), s. 562–573. doi: 10.1002/ana.26431.
Kristoffersen, Espen Saxhaug; Bjorvatn, Bjørn; Halvorsen, Peder Andreas; Nilsen, Stein; Fossum, Guro Haugen & Fors, Egil Andreas [Vis alle 12 forfattere av denne artikkelen] (2022). The Norwegian PraksisNett: a nationwide practice-based research network with a novel IT infrastructure. Scandinavian Journal of Primary Health Care. ISSN 0281-3432. 40(2), s. 217–226. doi: 10.1080/02813432.2022.2073966. Fulltekst i vitenarkiv Vis sammendrag
Clinical research in primary care is relatively scarce. Practice-based research networks (PBRNs) are research infrastructures to overcome hurdles associated with conducting studies in primary care. In Norway, almost all 5.4 million inhabitants have access to a general practitioner (GP) through a patient-list system. This gives opportunity for a PBRN with reliable information about the general population. The aim of the current paper is to describe the establishment, organization and function of PraksisNett (the Norwegian Primary Care Research Network). Materials and Methods We describe the development, funding and logistics of PraksisNett as a nationwide PBRN. Results PraksisNett received funding from the Research Council of Norway for an establishment period of five years (2018–2022). It is comprised of two parts; a human infrastructure (employees, including academic GPs) organized as four regional nodes and a coordinating node and an IT infrastructure comprised by the Snow system in conjunction with the Medrave M4 system. The core of the infrastructure is the 92 general practices that are contractually linked to PraksisNett. These include 492 GPs, serving almost 520,000 patients. Practices were recruited during 2019–2020 and comprise a representative mix of rural and urban settings spread throughout all regions of Norway. Conclusion Norway has established a nationwide PBRN to reduce hurdles for conducting clinical studies in primary care. Improved infrastructure for clinical studies in primary care is expected to increase the attractiveness for studies on the management of disorders and diseases in primary care and facilitate international research collaboration. This will benefit both patients, GPs and society in terms of improved quality of care.
Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Winsvold, Bendik K S; O'Connell, Kevin Sean; Frei, Oleksandr & Shadrin, Alexey [Vis alle 39 forfattere av denne artikkelen] (2022). Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools. Brain. ISSN 0006-8950. 145(1), s. 142–153. doi: 10.1093/brain/awab267. Fulltekst i vitenarkiv Vis sammendrag
Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are implicated in both. A shared genetic basis to migraine and mental disorders has been suggested but previous studies have reported weak or non-significant genetic correlations and five shared risk loci. Using the largest samples to date and novel statistical tools, we aimed to determine the extent to which migraine’s polygenic architecture overlaps with bipolar disorder, depression and schizophrenia beyond genetic correlation, and to identify shared genetic loci. Summary statistics from genome-wide association studies were acquired from large-scale consortia for migraine (n cases = 59 674; n controls = 316 078), bipolar disorder (n cases = 20 352; n controls = 31 358), depression (n cases = 170 756; n controls = 328 443) and schizophrenia (n cases = 40 675, n controls = 64 643). We applied the bivariate causal mixture model to estimate the number of disorder-influencing variants shared between migraine and each mental disorder, and the conditional/conjunctional false discovery rate method to identify shared loci. Loci were functionally characterized to provide biological insights. Univariate MiXeR analysis revealed that migraine was substantially less polygenic (2.8 K disorder-influencing variants) compared to mental disorders (8100–12 300 disorder-influencing variants). Bivariate analysis estimated that 800 (SD = 300), 2100 (SD = 100) and 2300 (SD = 300) variants were shared between bipolar disorder, depression and schizophrenia, respectively. There was also extensive overlap with intelligence (1800, SD = 300) and educational attainment (2100, SD = 300) but not height (1000, SD = 100). We next identified 14 loci jointly associated with migraine and depression and 36 loci jointly associated with migraine and schizophrenia, with evidence of consistent genetic effects in independent samples. No loci were associated with migraine and bipolar disorder. Functional annotation mapped 37 and 298 genes to migraine and each of depression and schizophrenia, respectively, including several novel putative migraine genes such as L3MBTL2, CACNB2 and SLC9B1. Gene-set analysis identified several putative gene sets enriched with mapped genes including transmembrane transport in migraine and schizophrenia. Most migraine-influencing variants were predicted to influence depression and schizophrenia, although a minority of mental disorder-influencing variants were shared with migraine due to the difference in polygenicity. Similar overlap with other brain-related phenotypes suggests this represents a pool of ‘pleiotropic’ variants that influence vulnerability to diverse brain-related disorders and traits. We also identified specific loci shared between migraine and each of depression and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for experimental validation.
Bergh, Elin; Jahr, Silje Holt; Rønning, Ole Morten; Askim, Torunn; Thommessen, Bente & Kristoffersen, Espen Saxhaug (2022). Reasons and predictors of non-thrombolysis in patients with acute ischemic stroke admitted within 4.5 h. Acta Neurologica Scandinavica. ISSN 0001-6314. 146(1), s. 61–69. doi: 10.1111/ane.13622. Fulltekst i vitenarkiv Vis sammendrag
Abstract Objectives Thrombolytic treatment in acute ischemic stroke (AIS) reduces stroke-related disability. Nearly 40% of all patients with AIS (<4.5 h) receive thrombolysis, but there is a large variation in the use between hospitals. Little is known about reasons and predictors for not giving thrombolytic treatment. Therefore, we aimed to investigate reasons for non-thrombolysis in patients admitted within 4.5 h. Methods All patients with AIS (<4.5 h) admitted to Akershus University Hospital, Norway, between January 2015 and December 2017 were examined. Patient characteristics and reasons for not giving thrombolysis were registered. Descriptive statistics and logistic regression analyses were performed. Results Of 535 patients admitted with AIS (<4.5 h), 250 (47%) did not receive thrombolysis and of these only 26% had an absolute contraindication to treatment. Among the 74% with relative contraindications, the most common reasons given were mild and improving symptoms. Previous stroke (OR 3.32, 95%CI 1.99–5.52), arriving between 3 h and 4.5 h after onset (OR 7.76, 95%CI 3.73–16.11) or having mild symptoms (OR 2.33, 95%CI 1.56–3.49) were all significant predictors of not receiving thrombolytic treatment in the multivariable logistic regression model. Conclusion A large proportion of patients with AIS do not receive thrombolysis. This study highlights up-to-date findings that arriving late in the time window, mild symptoms, and previous stroke are strong predictors of non-treatment. It is uncertain whether there is an underuse of thrombolysis in AIS. Increasing the utility of thrombolysis in the 4.5 h time window must be weighed against possible harms.
Do, Thien Phu; Dømgaard, Mikala; Stefansen, Simon; Kristoffersen, Espen Saxhaug; Ashina, Messoud & Hansen, Jakob Møller (2022). Barriers and gaps in headache education: a national cross-sectional survey of neurology residents in Denmark. BMC Medical Education. ISSN 1472-6920. 22. doi: 10.1186/s12909-022-03299-6.
Siddiqui, Tahreem Ghazal; Bjelkarøy, Maria Torheim; Cheng, Socheat; Kristoffersen, Espen Saxhaug; Grambaite, Ramune & Lundqvist, Christofer (2022). The effect of cognitive function and central nervous system depressant use on mortality—A prospective observational study of previously hospitalised older patients. PLOS ONE. ISSN 1932-6203. 17(3). doi: 10.1371/journal.pone.0263024. Fulltekst i vitenarkiv
Romoli, Michele; Eusebi, Paolo; Forlivesi, Stefano; Gentile, Mauro; Giammello, Fabrizio & Piccolo, Laura [Vis alle 20 forfattere av denne artikkelen] (2021). Stroke network performance during the first COVID-19 pandemic stage: A meta-analysis based on stroke network models. International Journal of Stroke. ISSN 1747-4930. 16(7), s. 771–783. doi: 10.1177/17474930211041202.
Nogueira, Raul; Qureshi, Muhammad; Abdalkader, Mohamad; Martins, Sheila; Yamagami, Hiroshi & Qiu, Zhongming [Vis alle 50 forfattere av denne artikkelen] (2021). Global Impact of COVID-19 on Stroke Care and IV Thrombolysis. Neurology. ISSN 0028-3878. 96(23), s. e2824–e2838. doi: 10.1212/WNL.0000000000011885.
Bjelkarøy, Maria Torheim; Cheng, Socheat; Siddiqui, Tahreem Ghazal; Saltyte Benth, Jurate; Grambaite, Ramune & Kristoffersen, Espen Saxhaug [Vis alle 7 forfattere av denne artikkelen] (2021). The association between pain and central nervous system depressing medication among hospitalised Norwegian older adults. Scandinavian Journal of Pain. ISSN 1877-8860. s. 1–11. doi: 10.1515/sjpain-2021-0120. Fulltekst i vitenarkiv
Stubberud, Anker; Buse, Dawn C.; Kristoffersen, Espen Saxhaug; Linde, Mattias & Tronvik, Erling Andreas (2021). Is there a causal relationship between stress and migraine? Current evidence and implications for management. The Journal of Headache and Pain. ISSN 1129-2369. 22, s. 1–11. doi: 10.1186/s10194-021-01369-6. Fulltekst i vitenarkiv Vis sammendrag
Background The purpose of this narrative review is to examine the literature investigating a causal relationship between stress and migraine and evaluate its implications for managing migraine. Methods PubMed, PsycINFO and CINAHL were searched from 1988 to August 2021, identifying 2223 records evaluating the relationship between stress and migraine. Records were systematically screened. All potentially relevant records were thematically categorized into six mechanistic groups. Within each group the most recent reports providing new insights were cited. Results First, studies have demonstrated an association of uncertain causality between high stress loads from stressful life events, daily hassles or other sources, and the incidence of new-onset migraine. Second, major stressful life events seem to precede the transformation from episodic to chronic migraine. Third, there is some evidence for changes in levels of stress as a risk factor for migraine attacks. Research also suggests there may be a reversed causality or that stress-trigger patterns are too individually heterogeneous for any generalized causality. Fourth, migraine symptom burden seems to increase in a setting of stress, partially driven by psychiatric comorbidity. Fifth, stress may induce sensitization and altered cortical excitability, partially explaining attack triggering, development of chronic migraine, and increased symptom burden including interictal symptom burden such as allodynia, photophobia or anxiety. Finally, behavioral interventions and forecasting models including stress variables seem to be useful in managing migraine. Conclusion The exact causal relationships in which stress causes incidence, chronification, migraine attacks, or increased burden of migraine remains unclear. Several individuals benefit from stress-oriented therapies, and such therapies should be offered as an adjuvant to conventional treatment and to those with a preference. Further understanding the relationship between stress, migraine and effective therapeutic options is likely to be improved by characterizing individual patterns of stress and migraine, and may in turn improve therapeutics.
Kristoffersen, Espen Saxhaug; Faiz, Kashif Waqar; Hansen, Jakob Møller; Tronvik, Erling Andreas; Frich, Jan C & Lundqvist, Christofer [Vis alle 7 forfattere av denne artikkelen] (2021). The management and clinical knowledge of headache disorders among general practitioners in Norway: a questionnaire survey. The Journal of Headache and Pain. ISSN 1129-2369. 22(1), s. 1–11. doi: 10.1186/s10194-021-01350-3. Fulltekst i vitenarkiv Vis sammendrag
Background General practitioners (GPs) diagnose and manage a majority of headache patients seeking health care. With the aim to understand the potential for clinical improvement and educational needs, we performed a study to investigate Norwegian GPs knowledge about headache and its clinical management. Methods We invited GPs from a random sample of 130 Norwegian continuous medical education (CME) groups to respond to an anonymous questionnaire survey. Results 367 GPs responded to the survey (73% of invited CME groups, 7.6% of all GPs in Norway). Mean age was 46 (SD 11) years, with an average of 18 (SD 10) years of clinical experience. In general the national treatment recommendations were followed, while the International Classification of Headache Disorders and other international guidelines were rarely used. Overall, 80% (n = 292) of the GPs suggested adequate prophylactic medication for frequent episodic migraine, while 28% (n = 101) suggested adequate prophylactic medication for chronic tension-type headache (CTTH). Half (52%, n = 191)) of the respondents were aware that different types of acute headache medication can lead to medication-overuse headache (MOH), and 59% (n = 217) knew that prophylactic headache medication does not lead to MOH. GPs often used MRI in the diagnostic work-up. GPs reported that lack of good treatment options was a main barrier to more optimized treatment of headache patients. Conclusion The knowledge of management of CTTH and MOH was moderate compared to migraine among Norwegian GPs.
Harder, Aster V.E.; Winsvold, Bendik K S; Noordam, Raymond; Vijfhuizen, Lisanne S.; Børte, Sigrid & Kogelman, Lisette J.A. [Vis alle 22 forfattere av denne artikkelen] (2021). Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache. Annals of Neurology. ISSN 0364-5134. 90(2), s. 203–216. doi: 10.1002/ana.26146. Fulltekst i vitenarkiv Vis sammendrag
Objective Identifying common genetic variants that confer genetic risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). Replication was performed in a Norwegian sample of 144 cases from the Trondheim Cluster headache sample and 1,800 controls from the Nord-Trøndelag Health Survey (HUNT). Gene set and tissue enrichment analyses, blood cell-derived RNA-sequencing of genes around the risk loci and linkage disequilibrium score regression were part of the downstream analyses. Results An association was found with cluster headache for 4 independent loci (r2 < 0.1) with genomewide significance (p < 5 × 10−8), rs11579212 (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.33–1.72 near RP11-815 M8.1), rs6541998 (OR = 1.53, 95% CI = 1.37–1.74 near MERTK), rs10184573 (OR = 1.43, 95% CI = 1.26–1.61 near AC093590.1), and rs2499799 (OR = 0.62, 95% CI = 0.54–0.73 near UFL1/FHL5), collectively explaining 7.2% of the variance of cluster headache. SNPs rs11579212, rs10184573, and rs976357, as proxy SNP for rs2499799 (r2 = 1.0), replicated in the Norwegian sample (p < 0.05). Gene-based mapping yielded ASZ1 as possible fifth locus. RNA-sequencing indicated differential expression of POLR1B and TMEM87B in cluster headache patients. Interpretation This genomewide association study (GWAS) identified and replicated genetic risk loci for cluster headache with effect sizes larger than those typically seen in complex genetic disorders.
García-Azorín, David; Do, Thien Phu; Gantenbein, Andreas R.; Hansen, J. M.; Souza, Marcio Nattan P. & Obermann, Mark [Vis alle 12 forfattere av denne artikkelen] (2021). Delayed headache after COVID-19 vaccination: a red flag for vaccine induced cerebral venous thrombosis. The Journal of Headache and Pain. ISSN 1129-2369. 22(1), s. 1–5. doi: 10.1186/s10194-021-01324-5.
Bjørk, Marte-Helene; Kristoffersen, Espen Saxhaug; Tronvik, Erling Andreas & Nordeng, Hedvig Marie Egeland (2021). Management of cluster headache and other trigeminal autonomic cephalalgias in pregnancy and breastfeeding. European Journal of Neurology. ISSN 1351-5101. 28(7), s. 2443–2455. doi: 10.1111/ene.14864. Fulltekst i vitenarkiv Vis sammendrag
Many clinicians lack experience in managing trigeminal autonomic cephalalgias (TACs) in pregnancy and lactation. In addition to cluster headache, TACs include hemicrania continua, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache with conjunctival injection and tearing/autonomic symptoms (SUNCT/SUNA). Treating these rare, severe headache conditions often requires off-label drugs that have uncertain teratogenic potential. In the last few years, several new treatment options and safety documentation have emerged, but clinical guidelines are lacking. This narrative review aimed to provide an updated clinical guide and good clinical practice recommendations for the management of these debilitating headache disorders in pregnancy and lactation.
Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S; Sandset, Else Charlotte; Storstein, Anette & Faiz, Kashif Waqar (2021). Experiences, distress and burden among neurologists in Norway during the COVID-19 pandemic. PLOS ONE. ISSN 1932-6203. 16:e0246567(2), s. 1–14. doi: 10.1371/journal.pone.0246567. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Jahr, Silje Holt; Faiz, Kashif Waqar; Thommessen, Bente & Rønning, Ole M. (2021). Stroke admission rates before, during and after the first phase of the COVID-19 pandemic. Neurological Sciences. ISSN 1590-1874. 42(3), s. 791–798. doi: 10.1007/s10072-021-05039-y.
Pohl, Heiko; Do, Thien Phu; García-Azorín, David; Hansen, Jakob Møller; Kristoffersen, Espen Saxhaug & Nelson, Sarah E. [Vis alle 13 forfattere av denne artikkelen] (2021). Green Flags and headache: A concept study using the Delphi method. Headache. ISSN 0017-8748. 61(2), s. 300–309. doi: 10.1111/head.14054.
Kristoffersen, Espen Saxhaug; Jahr, Silje Holt; Faiz, Kashif Waqar; Storstein, Anette; Winsvold, Bendik K S & Sandset, Else Charlotte (2021). Acute stroke care during the first phase of COVID-19 pandemic in Norway. Acta Neurologica Scandinavica. ISSN 0001-6314. 143(4), s. 349–354. doi: 10.1111/ane.13392.
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Wyller, Torgeir Bruun; Kristoffersen, Espen Saxhaug & Lundqvist, Anders Christofer (2021). The patterns and burden of multimorbidity in geriatric patients with prolonged use of addictive medications. Aging Clinical and Experimental Research. ISSN 1594-0667. 33, s. 2857–2864. doi: 10.1007/s40520-021-01791-5. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Sandset, Else Charlotte; Winsvold, Bendik K S; Faiz, Kashif Waqar & Storstein, Anette Margrethe (2020). Experiences of telemedicine in neurological out-patient clinics during the COVID-19 pandemic. Annals of clinical and translational neurology. ISSN 2328-9503. s. 1–8. doi: 10.1002/acn3.51293. Fulltekst i vitenarkiv
Kristoffersen, Epen Saxhaug; Faiz, Kashif Waqar; Sandset, Else Charlotte; Storstein, Anette; Stefansen, Simon & Winsvold, Bendik K S [Vis alle 7 forfattere av denne artikkelen] (2020). Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway. The Journal of Headache and Pain. ISSN 1129-2369. 21(128). doi: 10.1186/s10194-020-01195-2. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Børte, Sigrid; Hagen, Knut; Zwart, John-Anker & Winsvold, Bendik K S (2020). Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study. BMJ Open. ISSN 2044-6055. 10. doi: 10.1136/bmjopen-2020-040685. Fulltekst i vitenarkiv Vis sammendrag
Objectives: To evaluate the association between caesarean section and migraine in a population-based register-linked cohort study. Setting: Data from the population-based Nord-Trøndelag Health Studies (HUNT2 and HUNT3) were linked to information from the Norwegian Medical Birth Registry. Participants: 65 343 participants responded to the headache questions in any of the two HUNT studies. Only those answering the headache questions in HUNT2 or 3 and had information about mode of delivery in the Norwegian Medical Birth Registry (born after 1967) were included. Our final sample consisted of 6592 women and 4602 men, aged 19–41 years. Outcomes: ORs for migraine given caesarean section. Analyses were performed in multivariate logistic regression models. Results: After adjusting for sex, age and fetal growth restriction, delivery by caesarean section was not associated with migraine later in life (OR 0.86, 95% CI 0.64 to 1.15). Delivery by caesarean section was associated with a reduced OR of non-migrainous headache (OR 0.77, 95% CI 0.60 to 0.99). Conclusion: No association was found between caesarean section and migraine in this population-based register-linked study.
Kristoffersen, Espen Saxhaug; Harper, Charlotte Elena; Vetvik, Kjersti; Zarnovicky, Svetozar; Hansen, Jakob Møller & Faiz, Kashif Waqar (2020). Incidence and mortality of cerebral venous thrombosis in a Norwegian population. Stroke. ISSN 0039-2499. 51(10), s. 3023–3029. doi: 10.1161/STROKEAHA.120.030800.
Ntaios, George; Michel, Patrik; Georgiopoulos, Georgios; Guo, Yutao; Li, Wencheng & Xiong, Jing [Vis alle 68 forfattere av denne artikkelen] (2020). Characteristics and outcomes in patients with COVID-19 and acute ischemic stroke: The Global COVID-19 Stroke Registry. Stroke. ISSN 0039-2499. s. 254–258. doi: 10.1161/STROKEAHA.120.031208.
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Stavem, Knut; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer (2020). Health-related quality of life in hospitalized older patients with versus without prolonged use of opioid analgesics, benzodiazepines, and z-hypnotics: a cross-sectional study. BMC Geriatrics. ISSN 1471-2318. 20(425), s. 1–9. doi: 10.1186/s12877-020-01838-8. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Børte, Sigrid; Hagen, Knut; Zwart, John-Anker & Winsvold, Bendik K S (2020). Migraine, obesity and body fat distribution - a population-based study. The Journal of Headache and Pain. ISSN 1129-2369. 21, s. 1–8. doi: 10.1186/s10194-020-01163-w. Fulltekst i vitenarkiv Vis sammendrag
Background: Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between obesity and headache in a large, population-based study where we could take into account body fat distribution, migraine subtypes and tension-type headache. Methods: The third population-based Nord-Trøndelag Health Study (HUNT3) included validated headache questionnaires and objective anthropometric measurements. Using a cross-sectional design, our sample consisted of 18,191 women and 14,985 men, aged 19 to 96 years. Of these 4290 (12.9%) had migraine, 4447 (13.4%) had frequent tension-type headache (TTH), and 24,439 were headache-free controls. A total of 5049 individuals with unclassified headache were excluded from the analyses. Using logistic regression, we modeled the association between obesity and headache prevalence, adjusting for relevant confounders. Results: Both total body obesity (TBO) and abdominal obesity (AO) were associated with a higher prevalence of migraine when compared to headache-free controls (OR 1.45 95% CI 1.32–1.59 and OR 1.29 95% CI 1.18–1.41, respectively), in particular for individuals < 50 years of age (OR 1.74 95% CI 1.54–1.98 and OR 1.89 95% CI 1.69–2.11). Similar results were seen for migraine with and without aura. Similar Overall, a weaker associations were as observed between obesity and TTH. There was a dose-response relationship between obesity categories and increased headache frequency in subjects with migraine. TBO was associated with migraine prevalence and attack frequency independent of AO. Conclusion: Both TBO and AO were associated with migraine prevalence and attack frequency. This association was largely limited to individuals < 50 years of age. TBO, rather than AO, may be a better measure of obesity in relation to migraine.
Diener, Hans-Christoph; Antonaci, Fabio; Braschinsky, Mark; Evers, Stefan; Jensen, Rigmor & Laínez, Jose Miguel [Vis alle 10 forfattere av denne artikkelen] (2020). European Academy of Neurology guideline on the management of medication-overuse headache. European Journal of Neurology. ISSN 1351-5101. 27(7), s. 1102–1116. doi: 10.1111/ene.14268. Fulltekst i vitenarkiv
Siddiqui, Tahreem Ghazal; Cheng, Socheat; Gossop, Michael; Kristoffersen, Espen Saxhaug; Grambaite, Ramune & Lundqvist, Christofer (2020). Association between prescribed central nervous system depressant drugs, comorbidity and cognition among hospitalised older patients: a cross-sectional study. BMJ Open. ISSN 2044-6055. 10(7). doi: 10.1136/bmjopen-2020-038432. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Jahr, Silje Holt; Thommessen, Bente & Rønning, Ole M. (2020). Effect of COVID-19 pandemic on stroke admission rates in a Norwegian population. Acta Neurologica Scandinavica. ISSN 0001-6314. 142, s. 632–636. doi: 10.1111/ane.13307. Fulltekst i vitenarkiv
Børte, Sigrid; Zwart, John-Anker; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Thomas, Laurent & Fritsche, Lars [Vis alle 18 forfattere av denne artikkelen] (2020). Mitochondrial genome-wide association study of migraine – the HUNT Study . Cephalalgia. ISSN 0333-1024. 40(6), s. 625–634. doi: 10.1177/0333102420906835. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S & Faiz, Kashif Waqar (2019). Prestige of neurological disorders among future neurologists in Norway. Acta Neurologica Scandinavica. ISSN 0001-6314. 139(6), s. 555–558. doi: 10.1111/ane.13087.
Kristoffersen, Espen Saxhaug; Saltyte Benth, Jurate; Straand, Jørund; Russell, Michael Bjørn & Lundqvist, Christofer (2019). Validity of self-reported assessment of severity of dependence scale in medication-overuse headache. Scandinavian Journal of Pain. ISSN 1877-8860. 19(4), s. 837–841. doi: 10.1515/sjpain-2019-0022.
Lundqvist, Christofer; Gossop, Michael; Russell, Michael Bjørn; Straand, Jørund & Kristoffersen, Espen Saxhaug (2019). Severity of Analgesic Dependence and Medication-overuse Headache . Journal of addiction medicine. ISSN 1932-0620. 13(5), s. 346–353. doi: 10.1097/ADM.0000000000000504.
Fetveit, Arne; Straand, Jørund; Bjorvatn, Bjørn & Kristoffersen, Espen Saxhaug (2019). Self-reported sleeplessness in 12,655 persons living in the north of Norway: The Tromsø Study. Sleep Science. ISSN 1984-0659. 12(3), s. 147–155. doi: 10.5935/1984-0063.20190070. Fulltekst i vitenarkiv
Hagen, Knut; Stovner, Lars Jacob; Nilsen, Kristian Bernhard; Kristoffersen, Espen Saxhaug & Winsvold, Bendik K S (2019). The impact of C-reactive protein levels on headache frequency in the HUNT study 2006-2008. BMC Neurology. ISSN 1471-2377. 19, s. 1–8. doi: 10.1186/s12883-019-1462-8. Fulltekst i vitenarkiv Vis sammendrag
Background: Increased high sensitivity C- reactive protein (hs-CRP) levels have been found in many earlier studies on migraine, and recently also in persons with migraine and insomnia. The aim of this study was to see whether these findings could be reproduced in a large-scale population-based study. Methods: A total of 50,807 (54%) out of 94,194 invited aged ≥20 years or older participated in the third wave of the Nord-Trøndelag Health Study study performed in 2006–2008. Among these, 38,807 (41%) had valid measures of hs-CRP and answered questions on headache and insomnia. Elevated hs-CRP was defined as > 3.0 mg/L. The crosssectional association with headache was estimated by multivariate analyses using multiple logistic regression. The precision of the odds ratio (OR) was assessed with 95% confidence interval (CI). Results: In the fully adjusted model, elevated hs-CRP was associated with migraine (OR 1.14, 95% CI 1.04–1.25) and migraine with aura (OR 1.15, 95% CI 1.03–1.29). The association was strongest among individuals with headache ≥15 days/month for any headache (OR 1.26, 95% CI 1.08–1.48), migraine (OR 1.62, 95% CI 1.21–2.17), and migraine with aura (OR 1.84, 95% CI 1.27–2.67). No clear relationship was found between elevated hs-CRP and headache less than 7 days/month or with insomnia. Conclusions: Cross-sectional data from this large-scale population-based study showed that elevated hs-CRP was associated with headache ≥7 days/month, especially evident for migraine with aura.
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer (2019). Sociodemographic, clinical and pharmacological profiles of medication misuse and dependence in hospitalised older patients in Norway: a prospective cross-sectional study. BMJ Open. ISSN 2044-6055. 9:e0311483(9), s. 1–9. doi: 10.1136/bmjopen-2019-031483. Fulltekst i vitenarkiv Vis sammendrag
OBJECTIVES: Timely recognition of medication misuse and dependence is crucial to avoid both adverse drug events and increasing health expenditure. Yet the detection of these disorders in older people remains challenging due to the paucity of evidence on characteristics of patients at risk. This study investigates sociodemographic, pharmacological and clinical characteristics and factors associated with prolonged medication use, misuse and dependence in hospitalised older patients, focusing on three commonly prescribed central nervous system depressants (CNSDs): opioid analgesics, benzodiazepines and z-hypnotics. DESIGN: A prospective, cross-sectional study complying with the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. SETTING: Somatic departments of the Akershus University Hospital, Norway. PARTICIPANTS: 246 patients aged 65-90 were included. OUTCOME MEASURES: Prolonged use was defined as using CNSDs for ≥4 weeks. Misuse and dependence were assessed with the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria for substance abuse and dependence. We used descriptive statistics to report patients' characteristics and logistic regression to demonstrate factors associated with prolonged use, and misuse or dependence. RESULTS: Forty per cent of participants reported using CNSDs for ≥4 weeks. The odds of prolonged use were higher for patients aged 75-84 (OR=2.32, 95% CI 1.16 to 4.65) and ≥85 (OR=3.33, 95% CI 1.25 to 8.87) vs <75 years, for pain intensity (OR=1.02, 95% CI 1.01 to 1.04), and polypharmacy versus no polypharmacy (OR=5.16, 95% CI 2.13 to 12.55). The odds were lower for patients who completed secondary education (OR=0.33, 95% CI 0.13 to 0.83) compared with those with only basic education. Factors associated with misuse or dependence were pain intensity (OR=1.02, 95% CI 1.01 to 1.04) and concurrent use of ≥2 CNSDs (OR=3.99, 95% CI 1.34 to 11.88). CONCLUSION: CNSD overuse is prevalent among hospitalised older patients, despite clear guidelines and recommendations. Our findings underline a need for stronger focus on responsible prescribing, timely detection and prevention of this issue, with special attention towards older patients, those with enhanced pain, polypharmacy and/or concurrent use of several CNSDs.
Snoer, A. H.; Lund, N.; Jensen, R. H.; Kristoffersen, Espen Saxhaug; Barloese, Mads & Hansen, J. M. (2019). More precise phenotyping of cluster headache using prospective attack reports. European Journal of Neurology. ISSN 1351-5101. doi: 10.1111/ene.13980.
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Kristoffersen, Espen Saxhaug & LUNDQVIST, CHRISTOFER (2019). The Severity of Dependence Scale detects medication misuse and dependence among hospitalized older patients. BMC Geriatrics. ISSN 1471-2318. 19(1), s. 1–8. doi: 10.1186/s12877-019-1182-3. Fulltekst i vitenarkiv
Aamodt, Anne Hege; Bjørk, Marte-Helene; Alstadhaug, Karl Bjørnar; Eldøen, Guttorm; Dueland, Aud Nome & Poole, Tine [Vis alle 14 forfattere av denne artikkelen] (2019). Praktisk håndtering av hodepine. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(7), s. 617–620. doi: 10.4045/tidsskr.18.0837. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Faiz, Kashif Waqar & Winsvold, Bendik K S (2019). Neurology residents’ knowledge of the management of headache. Cephalalgia. ISSN 0333-1024. 39(11), s. 1396–1406. doi: 10.1177/0333102419847973.
Kristoffersen, Espen Saxhaug; Stavem, Knut; LUNDQVIST, CHRISTOFER & Russell, Michael Bjørn (2019). The impact of chronic headache on workdays, unemployment and disutility in the general population. Journal of Epidemiology and Community Health. ISSN 0143-005X. doi: 10.1136/jech-2018-211127.
Kristoffersen, Espen Saxhaug; LUNDQVIST, CHRISTOFER & Russell, Michael Bjørn (2019). Illness perception in people With primary and secondary chronic headache in the general population. Journal of Psychosomatic Research. ISSN 0022-3999. 116, s. 83–92. doi: 10.1016/j.jpsychores.2018.12.001.
Bjorvatn, Bjørn; Pallesen, Ståle; Moen, Bente Elisabeth; Waage, Siri & Kristoffersen, Espen Saxhaug (2018). Migraine, tension-type headache and medication-overuse headache in a large population of shift working nurses: a cross-sectional study in Norway. BMJ Open. ISSN 2044-6055. 8(11), s. 1–7. doi: 10.1136/bmjopen-2018-022403. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Harper, Charlotte Elena; Vetvik, Kjersti & Faiz, Kashif Waqar (2018). Cerebral venetrombose – forekomst, diagnostikk og behandling. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(12). doi: 10.4045/tidsskr.17.1047.
Kristoffersen, Espen Saxhaug; Aaseth, Kjersti; Grande, Ragnhild Berling; LUNDQVIST, CHRISTOFER & Russell, Michael Bjørn (2018). Psychological distress, neuroticism and disability associated with secondary chronic headache in the general population - The Akershus study of chronic headache. The Journal of Headache and Pain. ISSN 1129-2369. 18(62). doi: 10.1186/s10194-018-0894-7. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Grande, Ragnhild Berling; Aaseth, Kjersti; Russell, Michael Bjørn & LUNDQVIST, CHRISTOFER (2018). Medication-overuse headache detoxification reduces headache disability - The Akershus study of chronic headache. European Journal of Neurology. ISSN 1351-5101. 25(9), s. 1140–1147. doi: 10.1111/ene.13674.
Faiz, Kashif Waqar & Kristoffersen, Espen Saxhaug (2018). Association between age and outpatient clinic arrival time: Myth or reality? BMC Health Services Research. ISSN 1472-6963. 18(235). doi: 10.1186/s12913-018-3057-2. Fulltekst i vitenarkiv
Alstadhaug, Karl Bjørnar; Ofte, Hilde Karen & Kristoffersen, Espen Saxhaug (2018). Prävention und Therapie des Medikamentenübergebrauchskopfschmerzes. Der Schmerz (Berlin. Print). ISSN 0932-433X. 32(3), s. 201–206. doi: 10.1007/s00482-018-0295-5.
Hagen, Knut; Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S; Stovner, Lars Jacob & Zwart, John-Anker (2018). Remission of chronic headache: An 11-year follow-up study. Data from the Nord-Trøndelag Health Surveys 1995–1997 and 2006–2008. Cephalalgia. ISSN 0333-1024. 38(14), s. 2026–2034 . doi: 10.1177/0333102418769940. Fulltekst i vitenarkiv
Kristoffersen, Espen Saxhaug; Stavem, Knut; LUNDQVIST, CHRISTOFER & Russell, Michael Bjørn (2018). Excessive daytime sleepiness in chronic migraine and chronic tension-type headache from the general population. Cephalalgia. ISSN 0333-1024. 38(5), s. 993–997. doi: 10.1177/0333102417721133.

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Mitsikostas, Dimos-Dimtirios D.; Caronna, Edoardo; De Tommaso, Marina; Deligianni, Christina I.; Ekizoglu, Esme & Bolay, Hayrunnisa [Vis alle 14 forfattere av denne artikkelen] (2024). Reply to the letter: Headaches during/after SARS-CoV-2 infection/vaccination can be primary and secondary as well as acute and chronic, by Finsterer J and Mehri S. European Journal of Neurology. ISSN 1351-5101. doi: 10.1111/ene.16308.
Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi & Posner, Daniel C. [Vis alle 57 forfattere av denne artikkelen] (2022). Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. ISSN 0028-0836. doi: 10.1038/s41586-022-05492-5. Vis sammendrag
In the version of this article initially published, the name of the PRECISE4Q Consortium was misspelled as “PRECISEQ” and has now been amended in the HTML and PDF versions of the article. Further, data in the first column of Supplementary Table 55 were mistakenly shifted and have been corrected in the file accompanying the HTML version of the article
Jahr, Silje Holt; Sandset, Else Charlotte; Faiz, Kashif Waqar; Larsen, Kristin Tveitan; Hillestad, Vigdis & Selseth, Maiken Nordahl [Vis alle 11 forfattere av denne artikkelen] (2022). PRE-HOSPITAL SYSTOLIC BLOOD PRESSURE AND DIAGNOSIS IN SUSPECTED STROKE: THE AKERSHUS STUDY OF ISCHEMIC STROKE AND THROMBOLYSIS-1.
Bjerkreim, Anna Therese; Jahr, Silje Holt; Faiz, Kashif Waqar; Larsen, Kristin Tveitan; Hillestad, Vigdis & Selseth, Maiken Nordahl [Vis alle 14 forfattere av denne artikkelen] (2022). TIME ON SCENE BEFORE ADMISSION OF ACUTE STROKE AND STROKE MIMICS: THE AKERSHUS STUDY OF ISCHEMIC STROKE AND THROMBOLYSIS-1.
Larsen, Kristin Tveitan; Selseth, Maiken Nordahl; Jahr, Silje Holt; Hillestad, Vigdis; Koubaa, Nojoud & Sandset, Else Charlotte [Vis alle 8 forfattere av denne artikkelen] (2022). IMPACT OF ANTITHROMBOTIC TREATMENT ON ASSOCIATIONS BETWEEN PREHOSPITAL SYSTOLIC BLOOD PRESSURE AND OUTCOMES IN ACUTE, SPONTANEOUS INTRACEREBRAL HAEMORRHAGE.
Koubaa, Nojoud; Larsen, Kristin Tveitan; Hillestad, Vigdis; Selseth, Maiken Nordahl; Jahr, Silje Holt & Faiz, Kashif Waqar [Vis alle 13 forfattere av denne artikkelen] (2022). EPIDEMIOLOGY AND CLINICAL PRESENTATION OF SPONTANEOUS CEREBELLAR HEMORRHAGE IN A NORWEGIAN POPULATION.
Krzywicka, Katarzyna; Sánchez Van Kammen, Mayte; Sousa, Diana Aguiar de; Heldner, Mirjam R; Aron, S & Jiang, D. [Vis alle 31 forfattere av denne artikkelen] (2022). DIRECT ORAL ANTICOAGULANTS FOR THE TREATMENT OF CEREBRAL VENOUS THROMBOSIS (DOAC-CVT).
Dharmi, Sanpreet Grewal; Vetvik, Kjersti; Zarnovicky, Svetozar; Hansen, Jakob Møller; Faiz, Kashif Waqar & Kristoffersen, Espen Saxhaug (2022). CLINICAL PRESENTATION AND LONG-TERM OUTCOMES OF CEREBRAL VENOUS THROMBOSIS IN A NORWEGIAN POPULATION.
Altmann, Marianne; Rønning, Ole Morten; Fure, Brynjar; Selnes, Per; Reichenbach, Antje & Kristoffersen, Espen Saxhaug [Vis alle 7 forfattere av denne artikkelen] (2022). SHORT- AND LONG-TERM MORTALITY AFTER LACUNAR INFARCT.
Do, Thien Phu; Dømgaard, Mikala; Stefansen, Simon; Kristoffersen, Espen Saxhaug; Ashina, Messoud & Møller Hansen, Jakob (2022). Barriers and gaps in headache education: a national cross-sectional survey of neurology residents in Denmark.
Aaseth, Kjersti; Dharmi, Sanpreet Grewal; Kravdal, Gunnhild; Zarnovicky, Svetozar; Faiz, Kashif Waqar & Vetvik, Kjersti [Vis alle 7 forfattere av denne artikkelen] (2022). Diagnostic work-up of acute headache and subarachnoid haemorrhage in a Norwegian population. European Journal of Neurology. ISSN 1351-5101. doi: 10.1111/ene.15465.
Bjelkarøy, Maria Torheim; Simonsen, Tone Breines; Siddiqui, Tahreem Ghazal; Halset, Sigrid; Cheng, Socheat & Grambaite, Ramune [Vis alle 10 forfattere av denne artikkelen] (2022). Brief intervention as a method for reducing use of z-hypnotics in older adult – a feasibility study .
Bjelkarøy, Maria Torheim; Simonsen, Tone Breines; Siddiqui, Tahreem Ghazal; Halset, Sigrid; Cheng, Socheat & Grambaite, Ramune [Vis alle 10 forfattere av denne artikkelen] (2022). Brief intervention as a method for reducing use of z-hypnotics in older adult – a feasibility study .
Nilsen, Stein; Bjorvatn, Bjørn & Kristoffersen, Espen Saxhaug (2021). PraksisNett- status etter tre år. Utposten. ISSN 0800-5680. 2-2021.
Bjelkarøy, Maria Torheim; Siddiqui, Tahreem Ghazal; Cheng, Socheat; Benth, Jurate Saltythè; Simonsen, Tone Breines & Halset, Sigrid [Vis alle 9 forfattere av denne artikkelen] (2021). Brief intervention as a method for reducing z hypnotics in the older adult a feasibility study.
Bjelkarøy, Maria Torheim; Cheng, Socheat; Siddiqui, Tahreem Ghazal; Benth, Jurate Saltythè; Grambaite, Ramune & Kristoffersen, Espen Saxhaug [Vis alle 7 forfattere av denne artikkelen] (2021). Pain and central nervous system depressing medication in hospitalised Norwegian older adults.
Bjelkarøy, Maria Torheim; Cheng, Socheat; Siddiqui, Tahreem Ghazal; Benth, Jurate Saltythè; Grambaite, Ramune & Kristoffersen, Espen Saxhaug [Vis alle 7 forfattere av denne artikkelen] (2021). Pain and central nervous system depressing medication in hospitalised Norwegian older adults.
Bjelkarøy, Maria Torheim; Cheng, Socheat; Siddiqui, Tahreem Ghazal; Benth, Jūratė Šaltytė; Grambaite, Ramune & Kristoffersen, Espen Saxhaug [Vis alle 7 forfattere av denne artikkelen] (2021). The association between pain and central nervous system depressing medication among hospitalised Norwegian older adults ( - and onwards from there; a pilot RCT).
Kristoffersen, Espen Saxhaug; Faiz, Kashif Waqar; Sandset, Else Charlotte; Storstein, Anette; Stefansen, Simon & Winsvold, Bendik K S [Vis alle 7 forfattere av denne artikkelen] (2020). Correction to: Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway (The Journal of Headache and Pain, (2020), 21, 1, (128), 10.1186/s10194-020-01195-2). The Journal of Headache and Pain. ISSN 1129-2369. 21(1). doi: 10.1186/s10194-020-01199-y.
Bjelkarøy, Maria Torheim; Cheng, Socheat; Siddiqui, Tahreem Ghazal; Grambaite, Ramune; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer (2020). P.424 Prolonged use of central nervous system depressant medication and cognitive function are associated with experienced pain among older adults.
Kristoffersen, Espen Saxhaug (2019). Cerebral venetrombose.
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer (2019). Characteristics of at-risk patients and a reliable screening tool for detecting medication dependence among elderly patients. European Journal of Neurology. ISSN 1351-5101. 26.
Siddiqui, Tahreem Ghazal; Cheng, Socheat; Grambaite, Ramune; Michele, Gossop; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer (2019). Long-term use of central nervous system depressant medications is associated with reduced cognitive function in hospitalised older patients: a cross sectional study. European Journal of Neurology. ISSN 1351-5101. 26.
Harper, Charlotte Elena; Faiz, Kashif Waqar; Vetvik, Kjersti; Zarnovicky, Svetozar; Hansen, Jakob Møller & Kristoffersen, Espen Saxhaug (2019). Incidence and mortality of cerebral venous thrombosis in a Norwegian population. European Journal of Neurology. ISSN 1351-5101. 26, s. 382–382.
Kristoffersen, Espen Saxhaug; REICHENBACH, ANTJE; Faiz, Kashif Waqar; Altmann, Marianne; Sundseth, Antje & Thommessen, Bente [Vis alle 7 forfattere av denne artikkelen] (2019). Is it possible to detect large-vessel occlusions in acute ischemic stroke using screening scales? European Journal of Neurology. ISSN 1351-5101. 26.
Harper, Charlotte Elena; Faiz, Kashif Waqar; Vetvik, Kjersti; Zarnovicky, Svetozar; Hansen, Jakob Møller & Kristoffersen, Espen Saxhaug (2019). INCIDENCE AND MORTALITY OF CEREBRAL VENOUS THROMBOSIS IN A NORWEGIAN POPULATION. European Stroke Journal. ISSN 2396-9873. 4, s. 321–322. doi: 10.1177/2396987319845581.
Kristoffersen, Espen Saxhaug; REICHENBACH, ANTJE; Faiz, Kashif Waqar; Altmann, Marianne; Sundseth, Antje & Thommessen, Bente [Vis alle 7 forfattere av denne artikkelen] (2019). IS IT POSSIBLE TO DETECT LARGE-VESSEL OCCLUSIONS IN ACUTE ISCHEMIC STROKE USING CLINICAL SCREENING SCALES? European Stroke Journal. ISSN 2396-9873. 4. doi: 10.1177/2396987319845578.
Kristoffersen, Espen Saxhaug; REICHENBACH, ANTJE; Faiz, Kashif Waqar; Bergh, Elin; Baar, Anette & Altmann, Marianne [Vis alle 9 forfattere av denne artikkelen] (2019). Prehospital tidsbruk ved hjerneslag. Tid brukt på hentested.
Harper, Charlotte Elena; Faiz, Kashif Waqar; Aaseth, Kjersti; Vetvik, Kjersti & Kristoffersen, Espen Saxhaug (2019). Reinnleggelse i nevrologisk avdeling grunnet postpunksjonshodepine etter utredning av akutt hodepine.
Aaseth, Kjersti; Harper, Charlotte Elena; Vetvik, Kjersti; Faiz, Kashif Waqar & Kristoffersen, Espen Saxhaug (2019). Utredning av subaraknoidalblødning – fortsatt behov for spinalpunksjon?
Carlsen, Louise N; Høst, Christel; Dømgaard, Mikala; Kristoffersen, Espen Saxhaug & Jensen, Rigmor Højland (2019). Brief Intervention – treatment of medication overuse headache in primary and secondary care, a study protocol. Cephalalgia. ISSN 0333-1024. 39. doi: 10.1177/0333102419859835.
Snoer, A. H.; Lund, Nunu; Jensen, Rigmor Højland; Kristoffersen, Espen Saxhaug; Barloese, Mads & Hansen, Jakob Møller (2019). More precise phenotyping of cluster headache using prospective attack reports. Cephalalgia. ISSN 0333-1024. 39. doi: 10.1177/0333102419859835.
Carlsen, Louise N; Høst, Christel; Dømgaard, Mikala; Kristoffersen, Espen Saxhaug; Jensen, Rigmor Højland & Hansen, Jakob Møller (2019). Brief Intervention – treatment of medication overuse headache in primary and secondary care, a study protocol.
Snoer, A. H.; Lund, Nunu; Jensen, Rigmor Højland; Kristoffersen, Espen Saxhaug; Barloese, Mads & Hansen, Jakob Møller (2019). More precise phenotyping of cluster headache using prospective attack reports.
Kristoffersen, Espen Saxhaug & Møller Hansen, Jakob (2019). Headache? Go see your GP!
Kristoffersen, Espen Saxhaug & Møller Hansen, Jakob (2019). Management of the difficult headache patient in general practice.
Siddiqui, Tahreem Ghazal; Cheng, Socheat; Kristoffersen, Espen Saxhaug; Gossop, Michael; Grambaite, Ramune & Lundqvist, Christofer (2019). The association between central nervous system depressant medications and cognitive function in hospitalised older patients: a cross sectional study. .
Siddiqui, Tahreem Ghazal; Cheng, Socheat; Kristoffersen, Espen Saxhaug; Gossop, Michael; Grambaite, Ramune & Lundqvist, Christofer (2019). Prescribed Central Nervous System Depressants are associated with Cognitive side effects among older patients.
Siddiqui, Tahreem Ghazal; Cheng, Socheat; Gossop, Michael; Kristoffersen, Espen Saxhaug; Grambaite, Ramune & Lundqvist, Christofer (2019). Prescribed Central Nervous System Depressants are associated with reduced cognition among hospitalised older patients.
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer (2019). Disparities in quality of life between elderly patients with and without long-term use of opioids and benzodiazepines.
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer (2019). Characteristics of at-risk patients and a reliable screening tool for detecting medication dependence among elderly patients.
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Stavem, Knut; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer (2019). Overuse of opioids and benzidiazepines among elderly patients: Characteristics of at-risk patients and disparities in quality of life .
Siddiqui, Tahreem Ghazal; Cheng, Socheat; Grambaite, Ramune; Michele, Gossop; Kristoffersen, Espen Saxhaug & Lundqvist, Christofer (2019). Long-term use of central nervous system depressant medications is associated with reduced cognitive function in hospitalised older patients: a cross sectional study.
Bjorvatn, Bjørn; Kristoffersen, Espen Saxhaug; Halvorsen, Peder Andreas; Fors, Egil Andreas; Nilsen, Stein & Rørtveit, Guri (2019). Ny infrastruktur for allmennmedisinsk forskning. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(1), s. 24–26. doi: 10.4045/tidsskr.18.0689.
Faiz, Kashif Waqar; Kristoffersen, Espen Saxhaug; Sundseth, Antje & Altmann, Marianne (2018). Legefrakk og håndhygiene. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(20). doi: 10.4045/tidsskr.18.0695.
Kristoffersen, Espen Saxhaug (2018). Seleksjon, triagering og vurdering – prehospital- og mottaksmedisin.
Kristoffersen, Espen Saxhaug; Stavem, Knut; LUNDQVIST, CHRISTOFER & Russell, Michael Bjørn (2018). The impact of chronic headache on workdays, unemployment and disutility in the general population.
Kristoffersen, Espen Saxhaug; REICHENBACH, ANTJE; Faiz, Kashif Waqar; Altmann, Marianne; Sundseth, Antje & Thommessen, Bente [Vis alle 7 forfattere av denne artikkelen] (2018). Is it possible to identify acute ischemic stroke patients with large-vessel occlusions using clinical screening scales?
Kristoffersen, Espen Saxhaug; Grande, Ragnhild Berling; Aaseth, Kjersti; Russell, Michael Bjørn & LUNDQVIST, CHRISTOFER (2018). Hodepinerelatert livskvalitet før og etter seponering av medikamenter ved medikamentoverforbrukshodepine – Akershus-undersøkelsen av kronisk hodepine.
Harper, Charlotte Elena; Kristoffersen, Espen Saxhaug; Vetvik, Kjersti & Faiz, Kashif Waqar (2018). Forekomst og klinisk presentasjon av cerebral venetrombose i en norsk populasjon.
Kristoffersen, Espen Saxhaug; REICHENBACH, ANTJE; Faiz, Kashif Waqar; Altmann, Marianne; Sundseth, Antje & Thommessen, Bente [Vis alle 7 forfattere av denne artikkelen] (2018). Kan pasienter med akutt storkarokklusjon identifiseres med kliniske skåringsverktøy?
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Kristoffersen, Espen Saxhaug & LUNDQVIST, CHRISTOFER (2018). Diagnostic accuracy and usability of the severity dependence scale in detecting medication misuse and dependence in elderly patients .
Cheng, Socheat; Siddiqui, Tahreem Ghazal; Gossop, Michael; Kristoffersen, Espen Saxhaug & LUNDQVIST, CHRISTOFER (2018). Socio-demographic and pharmacological profile of medication Misuse and dependence in elderly patients .
Bjorvatn, Bjørn; Straand, Jørund; Halvorsen, Peder Andreas; Wensaas, Knut-Arne; Bellika, Johan Gustav & Fors, Egil Andreas [Vis alle 10 forfattere av denne artikkelen] (2018). PraksisNett - et nettverk av fastlegepraksiser. En storsatsing på forskning i allmennpraksis. Utposten. ISSN 0800-5680. s. 40–43.
Faiz, Kashif Waqar & Kristoffersen, Espen Saxhaug (2018). Snehvit og de syv diagnosene. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(6). doi: 10.4045/tidsskr.17.0850.
Jarholm, Jonas Alexander; Faiz, Kashif Waqar; Nysted, Trond; Zarnovicky, Svetozar & Kristoffersen, Espen Saxhaug (2018). Orbital Pain, Ophthalmoplegia, and Oligoclonal Bands in the Cerebrospinal Fluid: A Case Report of Tolosa-Hunt Syndrome. Headache. ISSN 0017-8748. 58(5), s. 758–760. doi: 10.1111/head.13283.
Kristoffersen, Espen Saxhaug; Stavem, Knut; LUNDQVIST, CHRISTOFER & Russell, Michael Bjørn (2018). Reply to the letter by Min et al. Cephalalgia. ISSN 0333-1024. 38(10), s. 1701–1702. doi: 10.1177/0333102417747213.
Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S & Faiz, Kashif Waqar (2017). The knowledge of residents in neurology about management of headache.
Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S & Faiz, Kashif Waqar (2017). The knowledge of residents in neurology about management of headache.
Kristoffersen, Espen Saxhaug; LUNDQVIST, CHRISTOFER & Russell, Michael Bjørn (2017). Socioeconomic impact, disability, psychological distress and illness perception of primary chronic headache in the general population – the Akershus study of chronic headache.
Jarholm, Jonas Alexander; Kristoffersen, Espen Saxhaug; Wohlleben, Christine; Zarnovicky, Svetozar & Faiz, Kashif Waqar (2017). Mat på hjernen.
Kristoffersen, Espen Saxhaug; Winsvold, Bendik K S & Faiz, Kashif Waqar (2017). Leger i spesialisering i nevrologi sin erfaring og håndtering av hodepine i klinisk praksis.
Kristoffersen, Espen Saxhaug; LUNDQVIST, CHRISTOFER & Russell, Michael Bjørn (2017). Sykdomsbyrde ved primær kronisk hodepine – Akershus-undersøkelsen av kronisk hodepine.

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Publisert 12. apr. 2011 16:57 - Sist endret 6. jan. 2024 13:33

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Espen Saxhaug Kristoffersen

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