Hege Beate Ihle-Hansen

• Hagberg, Guri; Ihle-Hansen, Haakon; Abzhandadze, Tamar; Reinholdsson, Malin; Viktorisson, Adam & Ihle-Hansen, Hege Beate [Vis alle 7 forfattere av denne artikkelen] (2024). The precision by the Face Arm Speech Time (FAST) algorithm in stroke capture, sex and age differences: a stroke registry study. BMJ Neurology Open. 6(1). doi: 10.1136/bmjno-2023-000574.
• Ihle-Hansen, Håkon; Hagberg, Guri; Ihle-Hansen, Hege Beate; Sandset, Else Charlotte; Andrade, Jason G. & Mandrola, John [Vis alle 7 forfattere av denne artikkelen] (2024). What Do We Really Know about the Effect of Prolonged Heart Rhythm Monitoring after Stroke? Stroke. ISSN 0039-2499. 55(4), s. 1136–1140. doi: 10.1161/STROKEAHA.123.045843.
• Jamtli, Bjørn; Hov, Maren Ranhoff; Jørgensen, Trine Møgster; Kramer-Johansen, Jo; Ihle-Hansen, Hege Beate & Sandset, Else Charlotte [Vis alle 8 forfattere av denne artikkelen] (2024). Telephone triage and dispatch of ambulances to patients with suspected and verified acute stroke - a descriptive study. BMC Emergency Medicine. ISSN 1471-227X. 24(1). doi: 10.1186/s12873-024-00962-7.
• Sanders, Anne-Marthe; Richard, Geneviève; Kolskår, Knut-Kristian; Ulrichsen, Kristine Moe; Alnæs, Dag & Dørum, Erlend Solberg [Vis alle 10 forfattere av denne artikkelen] (2024). Exploring the associations between physical activity level, cognitive performance, and response to computerized cognitive training among chronic stroke patients. Brain and Behavior. ISSN 2162-3279. 14(2). doi: 10.1002/brb3.3406.
• Amundsen, Erik Koldberg; Ihle-Hansen, Hege Beate; Kraglund, Kristian Lundsgaard & Hagberg, Guri (2024). Acute ischemic stroke and measurement of apixaban and rivaroxaban: an observational cohort implementation study. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 8(1). doi: 10.1016/j.rpth.2023.102307.
• Navickaite, Egle; Saltvedt, Ingvild Tina; Lydersen, Stian; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege Beate & Grambaite, Ramune [Vis alle 7 forfattere av denne artikkelen] (2024). Diagnostic accuracy of the Clock Drawing Test in screening for early post-stroke neurocognitive disorder: the Nor-COAST study. BMC Neurology. ISSN 1471-2377. 24(1). doi: 10.1186/s12883-023-03523-w. Fulltekst i vitenarkiv
• Hagberg, Guri; Ihle-Hansen, Håkon; Abzhandadze, Tamar; Reinholdsson, Malin; Ihle-Hansen, Hege Beate & Sunnerhagen, Kathrina Stibrant (2023). Prognostic value of acute National Institutes of Health Stroke Scale Items on disability: a registry study of first-ever stroke in the western part of Sweden. BMJ Open. ISSN 2044-6055. 13(12). doi: 10.1136/bmjopen-2023-080007.
• Vlachos, Georgios; Ihle-Hansen, Hege Beathe; Wyller, Torgeir Bruun; Brækhus, Anne; Mangset, Margrete & Hamre, Charlotta [Vis alle 7 forfattere av denne artikkelen] (2023). Factors Determining Not Returning to Full-Time Work 12 Months After Mild Ischemic Stroke. Archives of Rehabilitation Research and Clinical Translation. ISSN 2590-1095. 5(1). doi: 10.1016/j.arrct.2022.100245. Fulltekst i vitenarkiv
• Ihle-Hansen, Håkon; Vigen, Thea; Berge, Trygve; Walle-Hansen, Marte; Hagberg, Guri & Ihle-Hansen, Hege Beathe [Vis alle 12 forfattere av denne artikkelen] (2023). Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 12(17), s. 1–10. doi: 10.1161/JAHA.123.030739. Fulltekst i vitenarkiv
• Guterud, Mona; Bugge, Helge Fagerheim; Røislien, Jo; Kramer-Johansen, Jo; Toft, Mathias & Ihle-Hansen, Hege Beathe [Vis alle 11 forfattere av denne artikkelen] (2023). Prehospital screening of acute stroke with the National Institutes of Health Stroke Scale (ParaNASPP): a stepped-wedge, cluster-randomised controlled trial. Lancet Neurology. ISSN 1474-4422. 22(9), s. 800–811. doi: 10.1016/S1474-4422(23)00237-5.
• Ratajczak-Tretel, Barbara; Lambert, Anna Tancin; Al-Ani, Riadh Ibrahim Mahmud; Arntzen, Kathrine Grønning; Bakkejord, Grete & Bekkeseth, Hanna Marie Otterholt [Vis alle 32 forfattere av denne artikkelen] (2023). Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study. Journal of Neurology. ISSN 0340-5354. 270, s. 4049–4059. doi: 10.1007/s00415-023-11680-8. Fulltekst i vitenarkiv Vis sammendrag

  Background Atrial fibrillation (AF) detection and treatment are key elements to reduce recurrence risk in cryptogenic stroke (CS) with underlying arrhythmia. The purpose of the present study was to assess the predictors of AF in CS and the utility of existing AF-predicting scores in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study. Method The NOR-FIB study was an international prospective observational multicenter study designed to detect and quantify AF in CS and cryptogenic transient ischaemic attack (TIA) patients monitored by the insertable cardiac monitor (ICM), and to identify AF-predicting biomarkers. The utility of the following AF-predicting scores was tested: AS5F, Brown ESUS-AF, CHA2DS2-VASc, CHASE-LESS, HATCH, HAVOC, STAF and SURF. Results In univariate analyses increasing age, hypertension, left ventricle hypertrophy, dyslipidaemia, antiarrhythmic drugs usage, valvular heart disease, and neuroimaging findings of stroke due to intracranial vessel occlusions and previous ischemic lesions were associated with a higher likelihood of detected AF. In multivariate analysis, age was the only independent predictor of AF. All the AF-predicting scores showed significantly higher score levels for AF than non-AF patients. The STAF and the SURF scores provided the highest sensitivity and negative predictive values, while the AS5F and SURF reached an area under the receiver operating curve (AUC) > 0.7. Conclusion Clinical risk scores may guide a personalized evaluation approach in CS patients. Increasing awareness of the usage of available AF-predicting scores may optimize the arrhythmia detection pathway in stroke units.

• Sandvig, Heidi Vihovde; Aam, Stina; Alme, Katinka Nordheim; Askim, Torunn; Beyer, Mona K. & Ellekjær, Hanne [Vis alle 16 forfattere av denne artikkelen] (2023). Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study. Stroke. ISSN 0039-2499. 54(5), s. 1303–1311. doi: 10.1161/STROKEAHA.122.041965. Fulltekst i vitenarkiv
• Ihle-Hansen, Håkon; Bøås, Håkon; Tapia, German; Hagberg, Guri; Ihle-Hansen, Hege Beathe & Berild, Jacob Dag [Vis alle 10 forfattere av denne artikkelen] (2023). Stroke After SARS-CoV-2 mRNA Vaccine: A Nationwide Registry Study. Stroke. ISSN 0039-2499. 54(5), s. e190–e193. doi: 10.1161/STROKEAHA.122.040430.
• Ratajczak-Tretel, Barbara; Lambert, Anna Tancin; Al-Ani, Riadh Ibrahim Mahmud; Bekkeseth, Hanna Marie Otterholt; Bakkejord, Grete & Bjerkeli, Vigdis [Vis alle 31 forfattere av denne artikkelen] (2023). Underlying causes of cryptogenic stroke and TIA in the nordic atrial fibrillation and stroke (NOR-FIB) study – the importance of comprehensive clinical evaluation. BMC Neurology. ISSN 1471-2377. 23(1), s. 1–10. doi: 10.1186/s12883-023-03155-0. Fulltekst i vitenarkiv Vis sammendrag

  Background Cryptogenic stroke is a heterogeneous condition, with a wide spectrum of possible underlying causes for which the optimal secondary prevention may differ substantially. Attempting a correct etiological diagnosis to reduce the stroke recurrence should be the fundamental goal of modern stroke management. Methods Prospective observational international multicenter study of cryptogenic stroke and cryptogenic transient ischemic attack (TIA) patients clinically monitored for 12 months to assign the underlying etiology. For atrial fibrillation (AF) detection continuous cardiac rhythm monitoring with insertable cardiac monitor (Reveal LINQ, Medtronic) was performed. The 12-month follow-up data for 250 of 259 initially included NOR-FIB patients were available for analysis. Results After 12 months follow-up probable stroke causes were revealed in 43% patients, while 57% still remained cryptogenic. AF and atrial flutter was most prevalent (29%). In 14% patients other possible causes were revealed (small vessel disease, large-artery atherosclerosis, hypercoagulable states, other cardioembolism). Patients remaining cryptogenic were younger (p<0.001), had lower CHA2DS2-VASc score (p<0.001) on admission, and lower NIHSS score (p=0.031) and mRS (p=0.016) at discharge. Smoking was more prevalent in patients that were still cryptogenic (p=0.014), while dyslipidaemia was less prevalent (p=0.044). Stroke recurrence rate was higher in the cryptogenic group compared to the group where the etiology was revealed, 7.7% vs. 2.8%, (p=0.091). Conclusion Cryptogenic stroke often indicates the inability to identify the cause in the acute phase and should be considered as a working diagnosis until efforts of diagnostic work up succeed in identifying a specific underlying etiology. Timeframe of 6-12-month follow-up may be considered as optimal. Trial registration ClinicalTrials.gov Identifier NCT02937077, EudraCT 2018-002298-23

• Lambert, Anna Tancin; Ratajczak-Tretel, Barbara; Al-Ani, Riadh Ibrahim Mahmud; Arntzen, Kathrine Grønning; Bakkejord, Grete & Bekkeseth, Hanna Marie Otterholt [Vis alle 35 forfattere av denne artikkelen] (2023). Biomarkers predictive of atrial fibrillation in patients with cryptogenic stroke. Insights from the Nordic Atrial Fibrillation and Stroke (NOR-FIB) study. European Journal of Neurology. ISSN 1351-5101. 30(5), s. 1352–1363. doi: 10.1111/ene.15746. Vis sammendrag

  Background There are currently no biomarkers used to select cryptogenic stroke (CS) patients for monitoring with insertable cardiac monitors (ICMs), the most effective tool for diagnosing atrial fibrillation (AF) in CS. The purpose of this study was to assess clinically available biomarkers as predictors of AF. Methods Eligible CS and cryptogenic transient ischemic attack (TIA) patients underwent 12-month monitoring with ICMs, clinical follow-up, and biomarker sampling. Levels of cardiac and thromboembolic biomarkers, taken within 14 days from symptom onset, were compared between patients diagnosed with AF (n=74) during monitoring and those without AF (n=185). Receiver operating characteristic (ROC) curves were created. Biomarkers reaching area under ROC curve (AUC) ≥ 0.7 were dichotomized by finding optimal cut-off values and used in logistic regression establishing their predictive value for increased risk of AF in unadjusted and adjusted models. Results B-type natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase, D-dimer, high-sensitivity cardiac Troponin I and T were significantly higher in the AF than non-AF group. BNP and NT-proBNP reached predefined AUC level, 0.755 and 0.725 respectively. Optimal cut-off values were 33.5 ng/L for BNP, and 87 ng/L for NT-proBNP. Regression analysis showed that NT-proBNP was a predictor of AF in both unadjusted, odds ratio (OR) 7.72 (95% confidence interval [CI] 3.16–18.87), and age and sex adjusted models, OR 4.82 (95% CI 1.79–12.96). Conclusion Several clinically established biomarkers were associated with AF. NT-proBNP performed best as AF predictor and could be used for selecting patients for long-term monitoring with ICMs.

• Walle-Hansen, Marte; Berge, Trygve; Vigen, Thea; Myrstad, Marius; Hagberg, Guri & Ihle-Hansen, Hege Beathe [Vis alle 14 forfattere av denne artikkelen] (2022). Systolic blood pressure at age 40 and cognitive function 25 years later: The Akershus Cardiac Examination (ACE) 1950 Study. Journal of Hypertension. ISSN 0263-6352. 41(1), s. 132–139. doi: 10.1097/HJH.0000000000003312.
• Vahedi, Ali; Eriksdotter, Maria; Ihle-Hansen, Hege; Wyller, Torgeir Bruun; Øksengård, Anne Rita & Fure, Brynjar (2022). Cognitive impairment in people with physical frailty using the phenotype model: A systematic review and meta analysis. International Journal of Geriatric Psychiatry. ISSN 0885-6230. 37(11), s. 1–12. doi: 10.1002/gps.5822. Fulltekst i vitenarkiv
• Ratajczak-Tretel, Barbara; Lambert, Anna Tancin; Al-Ani, Riadh Ibrahim Mahmud; Arntzen, Kathrine Grønning; Bakkejord, Grete & Bekkeseth, Hanna Marie Otterholt [Vis alle 33 forfattere av denne artikkelen] (2022). Atrial fibrillation in cryptogenic stroke and TIA patients in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Main results. European Stroke Journal. ISSN 2396-9873. 8(1), s. 148–156. doi: 10.1177/23969873221123122. Fulltekst i vitenarkiv Vis sammendrag

  Introduction: Secondary stroke prevention depends on proper identification of the underlying etiology and initiation of optimal treatment after the index event. The aim of the NOR-FIB study was to detect and quantify underlying atrial fibrillation (AF) in patients with cryptogenic stroke (CS) or transient ischaemic attack (TIA) using insertable cardiac monitor (ICM), to optimise secondary prevention, and to test the feasibility of ICM usage for stroke physicians. Patients and methods: Prospective observational international multicenter real-life study of CS and TIA patients monitored for 12 months with ICM (Reveal LINQ) for AF detection. Results: ICM insertion was performed in 91.5% by stroke physicians, within median 9 days after index event. Paroxysmal AF was diagnosed in 74 out of 259 patients (28.6%), detected early after ICM insertion (mean 48 ± 52 days) in 86.5% of patients. AF patients were older (72.6 vs 62.2; p< 0.001), had higher pre-stroke CHA₂DS₂-VASc score (median 3 vs 2; p< 0.001) and admission NIHSS (median 2 vs 1; p= 0.001); and more often hypertension (p = 0.045) and dyslipidaemia (p = 0.005) than non-AF patients. The arrhythmia was recurrent in 91.9% and asymptomatic in 93.2%. At 12-month follow-up anticoagulants usage was 97.3%.Discussion and conclusions: ICM was an effective tool for diagnosing underlying AF, capturing AF in 29% of the CS and TIA patients. AF was asymptomatic in most cases and would mainly have gone undiagnosed without ICM. The insertion and use of ICM was feasible for stroke physicians in stroke units. © The Author(s) 2022.

• Bugge, Helge Fagerheim; Guterud, Mona; Røislien, Jo; Larsen, Karianne; Ihle-Hansen, Hege & Toft, Mathias [Vis alle 8 forfattere av denne artikkelen] (2022). National Institutes of Health Stroke Scale scores obtained using a mobile application compared to the conventional paper form: A randomised controlled validation study. BMJ Innovations. ISSN 2055-8074. 9(1), s. 57–63. doi: 10.1136/bmjinnov-2022-000968. Fulltekst i vitenarkiv
• Hagberg, Guri; Ihle-Hansen, Håkon; Sandset, Else Charlotte; Jacobsen, Dag; Wimmer, Rolf Henning & Ihle-Hansen, Hege (2022). Long Term Cognitive Function After Cardiac Arrest: A Mini-Review. Frontiers in Aging Neuroscience. ISSN 1663-4365. 14, s. 1–8. doi: 10.3389/fnagi.2022.885226.
• Ulrichsen, Kristine Moe; Kolskår, Knut-Kristian; Richard, Geneviève; Pedersen, Mads Lund; Alnæs, Dag & Dørum, Erlend Solberg [Vis alle 13 forfattere av denne artikkelen] (2022). No add-on effect of tDCS on fatigue and depression in chronic stroke patients: A randomized sham-controlled trial combining tDCS with computerized cognitive training. Brain and Behavior. ISSN 2162-3279. 12(7). doi: 10.1002/brb3.2643. Fulltekst i vitenarkiv
• Kolskår, Knut-Kristian; Ulrichsen, Kristine Moe; Richard, Geneviève; Dørum, Erlend Solberg; de Schotten, Michel Thiebaut & Rokicki, Jaroslav [Vis alle 12 forfattere av denne artikkelen] (2022). Structural disconnectome mapping of cognitive function in poststroke patients. Brain and Behavior. ISSN 2162-3279. doi: 10.1002/brb3.2707. Fulltekst i vitenarkiv
• Fremstad, Kjell Otto; Lindenskov, Paal Helge H.; Ihle-Hansen, Hege; Jamtli, Bjørn; Kramer-Johansen, Jo & Hardeland, Camilla [Vis alle 8 forfattere av denne artikkelen] (2022). Veien inn til sykehus for pasienter innlagt ved mistanke om akutt hjerneslag. Sykepleien Forskning. ISSN 1890-2936. 17. doi: 10.4220/Sykepleienf.2022.89354. Fulltekst i vitenarkiv
• Nerdal, Vilde Kristine; Gjestad, Elise Ødegård; Saltvedt, Ingvild; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege & Ryum, Truls [Vis alle 8 forfattere av denne artikkelen] (2022). The relationship of acute delirium with cognitive and psychiatric symptoms after stroke: a longitudinal study. BMC Neurology. ISSN 1471-2377. 22(1). doi: 10.1186/s12883-022-02756-5. Fulltekst i vitenarkiv
• Vlachos, Georgios; Ihle-Hansen, Hege; Wyller, Torgeir Bruun; Brækhus, Anne; Mangset, Margrete & Hamre, Sophia Charlotta [Vis alle 7 forfattere av denne artikkelen] (2022). Predictors of cognitive and emotional symptoms 12 months after first-ever mild stroke. Neuropsychological Rehabilitation. ISSN 0960-2011. doi: 10.1080/09602011.2022.2038211. Fulltekst i vitenarkiv
• Strømsnes, Torbjørn Austveg; Hagen, Truls Jørgen Kaugerud; Ouyang, Menglu; Wang, Xia; Chen, Chen & Rygg, Silje-Emilie Soltvedt [Vis alle 20 forfattere av denne artikkelen] (2022). Pressor therapy in acute ischaemic stroke: an updated systematic review. European Stroke Journal. ISSN 2396-9873. 7(2), s. 99–116. doi: 10.1177/23969873221078136.
• Munthe-Kaas, Ragnhild; Aam, Stina; Saltvedt, Ingvild; Wyller, Torgeir Bruun; Pendlebury, Sarah T. & Lydersen, Stian [Vis alle 10 forfattere av denne artikkelen] (2022). Is Frailty Index a better predictor than pre-stroke modified Rankin Scale for neurocognitive outcomes 3-months post-stroke? BMC Geriatrics. ISSN 1471-2318. 22(1). doi: 10.1186/s12877-022-02840-y. Fulltekst i vitenarkiv
• Dahl, Fredrik Andreas; Barra, Mathias; Faiz, Kashif Waqar; Ihle-Hansen, Hege; Næss, Halvor & Rand, Kim [Vis alle 10 forfattere av denne artikkelen] (2022). Stroke unit demand in Norway – present and future estimates. BMC Health Services Research. ISSN 1472-6963. 22. doi: 10.1186/s12913-021-07385-1. Fulltekst i vitenarkiv Vis sammendrag

  Background All stroke patients should receive timely admission to a stroke unit (SU). Consequently, most patients with suspected strokes – including stroke mimics (SM) are admitted. The aim of this study was to estimate the current total demand for SU bed capacity today and give estimates for future (2020–2040) demand. Methods Time trend estimates for stroke incidence and time constant estimates for length of stay (LOS) were estimated from the Norwegian Patient Registry (2010–2015). Incidence and LOS models for SMs were based on data from Haukeland University Hospital (2008–2017) and Akershus University Hospital (2020), respectively. The incidence and LOS models were combined with scenarios from Statistic Norway’s population predictions to estimate SU demands for each health region. A telephone survey collected data on the number of currently available SU beds. Results In 2020, 361 SU beds are available, while demand was estimated to 302. The models predict a reduction in stroke incidence, which offsets projected demographic shifts. Still, the estimated demand for 2040 rose to 316, due to an increase in SMs. A variation of this reference scenario, where stroke incidence was frozen at the 2020-level, gave a 2040-demand of 480 beds. Conclusions While the stroke incidence is likely to continue to fall, this appears to be balanced by an increase in SMs. An important uncertainty is how long the trend of decreasing stroke incidence can be expected to continue. Since the most important uncertainty factors point toward a potential increase, which may be as large as 50%, we would recommend that the health authorities plan for a potential increase in the demand for SU bed capacity.

• Efjestad, Anne; Ihle-Hansen, Hege; Hjellvik, Vidar; Engedal, Knut & Blix, Hege Salvesen (2022). Use of Drugs With Risk of Heart Rate-Related Problems is Common in Norwegian Dementia Patients Treated With Acetylcholinesterase Inhibitors: A Prevalence Study Based on the Norwegian Prescription Database . Frontiers in Pharmacology. ISSN 1663-9812. 12, s. 1–12. doi: 10.3389/fphar.2021.791578. Fulltekst i vitenarkiv Vis sammendrag

  Background: Drugs commonly prescribed for heart rate control may induce adverse drug reactions in Alzheimer patients treated with acetylcholinesterase inhibitors (AChEIs). We have studied use of drugs with a known risk of Torsades de pointes (TdP) and drugs used to treat behavioral and psychological symptoms of dementia, as well as a combination of drugs with a known risk of TdP and drugs with a known heart rate-lowering effect, before and after initiating treatment with AChEIs. Methods: The study applied data from the Norwegian Prescription Database for the period 2004-2016. Prescriptions of concomitant use of drugs in persistent users of AChEIs was studied in a follow-up period from 4 years before to 2 years after AChEI initiation in men and women of two age groups: 37-80 and 81-88 years. Results: A small number of patients were prescribed haloperidol (∼1.5% The second year after AChEI initiation), digoxin/digitoxin (∼3%), and verapamil (∼1.3%), while a substantial proportion of the patients were prescribed betablockers (∼28%) and citalopram/escitalopram (∼17%). During follow-up, up to 6% of the study population were prescribed both betablockers and citalopram/citalopram in addition to AChEIs, a combination that increased over the follow-up period and was observed most frequently in women in the oldest age group. Conclusions: A large proportion (∼44%) of patients treated with AChEIs were prescribed drugs that could cause bradycardic and prolonged time from the start of the Q wave to the end of the T wave (QT interval). Thus, action should be taken to reduce the combination of drugs with risk of bradycardia and prolonged QT interval. Medication review on a regular basis could be an option as an important risk-reducing intervention.

• Langhammer, Birgitta; Ihle-Hansen, Hege; Indredavik, Bent & Askim, Torunn (2022). Perceived Caregiver Strain, 3- and 18-Month Poststroke, in a Cohort of Caregivers from the Life after Stroke Trial (LAST). Nursing Research and Practice. ISSN 2090-1429. 2022. doi: 10.1155/2022/2619893. Fulltekst i vitenarkiv Vis sammendrag

  Aim: to gain more knowledge of caregiver strain in the Life After Stroke (LAST) population. Methods: This is a sub-study of the LAST study, including all caregivers reports of perceived Caregiver strain index (CSI) at inclusion and at 18 months follow-up irrespective of group allocation. The checklist “STROBE Statement—Checklist of items that should be included in reports of cohort studies” was used. Caregivers to adults (age ≥18 years), here defined as the person living with, a patient with a first-ever or recurrent stroke, community dwelling, with modified Rankin Scale (mRS)<5 and no serious comorbidities, was invited to fill out the Caregiver Strain Index at three months (10-16 weeks) post-stroke. Domains indicating differences of change in perceived strain in the total sample were analyzed in a linear regression analysis. Results: Caregiver strain (n=147) varying from 5% to 27% was reported by the caregivers at baseline and between 2% to18% at 18-months follow-up. The Items indicating the highest level of strain at baseline and 18-months were: “Caregiving is confining”, “There have been changes in personal plans”, and “There have been emotional adjustments” and “I feel completely overwhelmed”. The sample divided in age 0-79 years age 80 –100 years, indicated a higher strain on the caregiver for persons 80-100 years at 18-months. Conclusion: Caregiver strain was relatively low both at baseline and at 18-months follow-up. Main caregiver strains were reported in terms of; a sense of confinement, a tendency of emotional strain and the altering of plans at both timepoints. Depression was one of the main explanatory factors for perceived caregiver strain. The perception of caregiver strain was higher in age groups 80-100 years than age groups 0-79 years.

• Ihle-Hansen, Håkon; Ihle-Hansen, Hege; Sandset, Else Charlotte & Hagberg, Guri (2021). Subclinical Carotid Artery Atherosclerosis and Cognitive Function: A Mini-Review. Frontiers in Neurology. ISSN 1664-2295. 12. doi: 10.3389/fneur.2021.705043.
• Ihle-Hansen, Håkon; Ihle-Hansen, Hege; Fure, Brynjar; Thommessen, Bente; Helland, Gisle Berg & Øksengård, Anne Rita [Vis alle 10 forfattere av denne artikkelen] (2021). Carotid Atherosclerosis and Longitudinal Changes of MRI Visual Rating Measures in Stroke Survivors: A Seven-Year Follow-Up Study. Journal of Stroke & Cerebrovascular Diseases. ISSN 1052-3057. 30(10), s. 1–6. doi: 10.1016/j.jstrokecerebrovasdis.2021.106010. Fulltekst i vitenarkiv
• Ihle-Hansen, Håkon; Hagberg, Guri; Sandset, Else Charlotte; Ihle-Hansen, Hege; Amundsen, Erik Koldberg & Sandset, Per Morten [Vis alle 7 forfattere av denne artikkelen] (2021). Reversering av antikoagulerende legemidler ved hjerneblødning. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(14), s. 1–6. doi: 10.4045/tidsskr.21.0063. Fulltekst i vitenarkiv
• Efjestad, Anne; Ihle-Hansen, Hege; Hjellvik, Vidar; Engedal, Knut & Blix, Hege Salvesen (2021). Sex differences in psychotropic and analgesic drug use before and after initiating treatment with acetylcholinesterase inhibitors. PLOS ONE. ISSN 1932-6203. 16(9). doi: 10.1371/journal.pone.0243804. Fulltekst i vitenarkiv Vis sammendrag

  Background/aims The aim was to explore the impact of sex on prevalence, patterns and trends in the prescription of psychotropics and analgesics in users of acetylcholinesterase inhibitors (AChEIs), before and after AChEI initiation, compared to the general population. Methods A prospective study applying data from the Norwegian Prescription Database (NorPD) in the period 2004–2016. Prescription of antidepressants, antipsychotics, analgesics including opioids, benzodiazepines and z-hypnotics in persistent AChEI users was studied in a follow-up period from four years before to two years after AChEI initiation in men and women of four age groups: 37–64, 65–72, 73–80 and 81–88 years. Results Use of antidepressants, antipsychotics and weaker analgesics increased in both sexes during the follow-up period in 11.764 persistent AChEI users. Women with pre-dementia and dementia stages of AD showed a prescription pattern with more use of psychotropics and opioids than men, except for antipsychotics. Conclusion Female sex showed to have a significant influence on the prescriptions of psychotropics and analgesics in AD patients in a pre-dementia and dementia stage. The exception is for antipsychotics, that men used more than women. The prescription pattern showed a higher extent of polypharmacy of psychotropics and/or opioids in women than in men. The total prescription pattern of analgesics could indicate an undertreatment of pain in pre-dementia and dementia stages, most pronounced in men.

• Aam, Stina; Gynnild, Mari Nordbø; Munthe-Kaas, Ragnhild; Saltvedt, Ingvild; Lydersen, Stian & Knapskog, Anne Brita [Vis alle 10 forfattere av denne artikkelen] (2021). The Impact of Vascular Risk Factors on Post-stroke Cognitive Impairment: The Nor-COAST Study. Frontiers in Neurology. ISSN 1664-2295. 12, s. 1–11. doi: 10.3389/fneur.2021.678794. Fulltekst i vitenarkiv Vis sammendrag

  Introduction: Post-stroke cognitive impairment (PSCI) is common, but evidence on the impact of vascular risk factors is lacking. We explored the association between pre-stroke vascular risk factors and PSCI and studied the course of PSCI. Materials and Methods: Vascular risk factors were collected at baseline in stroke survivors (n = 635). Cognitive assessments of attention, executive function, memory, language, and the Montreal Cognitive Assessment (MoCA) were performed at 3 and/or 18 months post-stroke. Stroke severity was assessed with the National Institutes of Health Stroke Scale (NIHSS). PSCI was measured with global z; MoCA z-score; and z-score of the four assessed cognitive domains. Mixed-effect linear regression was applied with global z, MoCA z-score, and z-scores of the cognitive domains as dependent variables. Independent variables were the vascular risk factors (hypertension, hypercholesterolemia, smoking, diabetes mellitus, atrial fibrillation, coronary heart disease, previous stroke), time, and the interaction between these. The analyses were adjusted for age, education, and sex. There were between 5 and 25% missing data for the variables for PSCI. Results: Mean age was 71.6 years (SD 11.7); 42% were females; and the mean NIHSS score at admittance was 3.8 (SD 4.8). Regardless of vascular risk factors, global z, MoCA, and all the assessed cognitive domains were impaired at 3 and 18 months, with MoCA being the most severely impaired. Atrial fibrillation (AF) was associated with poorer language at 18 months and coronary heart disease (CHD) with poorer MoCA at 18 months (LR = 12.80, p = 0.002, and LR = 8.32, p = 0.004, respectively). Previous stroke was associated with poorer global z and attention at 3 and 18 months (LR = 15.46, p < 0.001, and LR = 16.20, p < 0.001). In patients without AF, attention improved from 3 to 18 months, and in patients without CHD, executive function improved from 3 to 18 months (LR = 10.42, p < 0.001, and LR = 9.33, p = 0.009, respectively). Discussion: Our findings indicate that a focal stroke lesion might be related to pathophysiological processes leading to global cognitive impairment. The poorer prognosis of PSCI in patients with vascular risk factors emphasizes the need for further research on complex vascular risk factor interventions to prevent PSCI.

• Schellhorn, Till; Zucknick, Manuela; Askim, Torunn; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege & Seljeseth, Yngve Müller [Vis alle 13 forfattere av denne artikkelen] (2021). Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study. BMC Geriatrics. ISSN 1471-2318. 21:362, s. 1–10. doi: 10.1186/s12877-021-02327-2. Fulltekst i vitenarkiv Vis sammendrag

  Background: Chronic brain pathology and pre-stroke cognitive impairment (PCI) is predictive of post-stroke dementia. The aim of the current study was to measure pre-stroke neurodegenerative and vascular disease burden found on brain MRI and to assess the association between pre-stroke imaging pathology and PCI, whilst also looking for potential sex differences. Methods: This prospective brain MRI cohort is part of the multicentre Norwegian cognitive impairment after stroke (Nor-COAST) study. Patients hospitalized with acute ischemic or hemorrhagic stroke were included from five participating stroke units. Visual rating scales were used to categorize baseline MRIs (N = 410) as vascular, neurodegenerative, mixed, or normal, based on the presence of pathological imaging findings. Pre-stroke cognition was assessed by interviews of patients or caregivers using the Global Deterioration Scale (GDS). Stroke severity was assessed with the National Institute of Health Stroke Scale (NIHSS). Univariate and multiple logistic regression analyses were performed to investigate the association between imaging markers, PCI, and sex. Results: Patients’ (N = 410) mean (SD) age was 73.6 (±11) years; 182 (44%) participants were female, the mean (SD) NIHSS at admittance was 4.1 (±5). In 68% of the participants, at least one pathological imaging marker was found. Medial temporal lobe atrophy (MTA) was present in 30% of patients, white matter hyperintensities (WMH) in 38% of patients and lacunes in 35% of patients. PCI was found in 30% of the patients. PCI was associated with cerebrovascular pathology (OR 2.5; CI = 1.4 to 4.5, p = 0.001) and mixed pathology (OR 3.4; CI = 1.9 to 6.1, p = 0.001) but was not associated with neurodegeneration (OR 1.0; CI = 0.5 to 2.2; p = 0.973). Pathological MRI markers, including MTA and lacunes, were more prevalent among men, as was a history of clinical stroke prior to the index stroke. The OR of PCI for women was not significantly increased (OR 1.2; CI = 0.8 to 1.9; p = 0.3).

• Ulrichsen, Kristine Moe; Kolskår, Knut-Kristian; Richard, Geneviève; Alnæs, Dag; Dørum, Erlend Solberg & Sanders, Anne-Marthe [Vis alle 13 forfattere av denne artikkelen] (2021). Structural brain disconnectivity mapping of post-stroke fatigue. NeuroImage: Clinical. ISSN 2213-1582. 30. doi: 10.1016/j.nicl.2021.102635. Fulltekst i vitenarkiv
• Vlachos, Georgios; Ihle-Hansen, Hege; Wyller, Torgeir Bruun; Brækhus, Anne; Mangset, Margrete & Hamre, Sophia Charlotta [Vis alle 7 forfattere av denne artikkelen] (2021). Cognitive and emotional symptoms in patients with first-ever mild stroke: The syndrome of hidden impairments. Journal of Rehabilitation Medicine. ISSN 1650-1977. 53:jrm00135, s. 1–7. doi: 10.2340/16501977-2764. Fulltekst i vitenarkiv
• Einstad, Marte Stine; Saltvedt, Ingvild; Lydersen, Stian; Ursin, Marie Helene; Munthe-Kaas, Ragnhild & Ihle-Hansen, Hege [Vis alle 13 forfattere av denne artikkelen] (2021). Associations between post-stroke motor and cognitive function: a cross-sectional study. BMC Geriatrics. ISSN 1471-2318. 21, s. 1–10. doi: 10.1186/s12877-021-02055-7. Fulltekst i vitenarkiv Vis sammendrag

  Background: Motor and cognitive impairments are frequently observed following stroke, but are often managed as distinct entities, and there is little evidence regarding how they are related. The aim of this study was to describe the prevalence of concurrent motor and cognitive impairments 3 months after stroke and to examine how motor performance was associated with memory, executive function and global cognition. Methods: The Norwegian Cognitive Impairment After Stroke (Nor-COAST) study is a prospective multicentre cohort study including patients hospitalized with acute stroke between May 2015 and March 2017. The National Institutes of Health Stroke Scale (NIHSS) was used to measure stroke severity at admission. Level of disability was assessed by the Modified Rankin Scale (mRS). Motor and cognitive functions were assessed 3 months post-stroke using the Montreal Cognitive Assessment (MoCA), Trail Making Test Part B (TMT-B), 10-Word List Recall (10WLR), Short Physical Performance Battery (SPPB), dual-task cost (DTC) and grip strength (Jamar®). Cut-offs were set according to current recommendations. Associations were examined using linear regression with cognitive tests as dependent variables and motor domains as covariates, adjusted for age, sex, education and stroke severity. Results: Of 567 participants included, 242 (43%) were women, mean (SD) age was 72.2 (11.7) years, 416 (75%) had an NIHSS score ≤ 4 and 475 (84%) had an mRS score of ≤2. Prevalence of concurrent motor and cognitive impairment ranged from 9.5% for DTC and 10WLR to 22.9% for grip strength and TMT-B. SPPB was associated with MoCA (regression coefficient B = 0.465, 95%CI [0.352, 0.578]), TMT-B (B = -9.494, 95%CI [− 11.726, − 7.925]) and 10WLR (B = 0.132, 95%CI [0.054, 0.211]). Grip strength was associated with MoCA (B = 0.075, 95%CI [0.039, 0.112]), TMT-B (B = -1.972, 95%CI [− 2.672, − 1.272]) and 10WLR (B = 0.041, 95%CI [0.016, 0.066]). Higher DTC was associated with more time needed to complete TMT-B (B = 0.475, 95%CI [0.075, 0.875]) but not with MoCA or 10WLR.

• Hamre, Sophia Charlotta; Fure, Brynjar; Helbostad, Jorunn L.; Wyller, Torgeir Bruun; Ihle-Hansen, Hege & Vlachos, Georgios [Vis alle 8 forfattere av denne artikkelen] (2021). Factors Associated with Level of Physical Activity After Minor Stroke. Journal of Stroke & Cerebrovascular Diseases. ISSN 1052-3057. 30(4). doi: 10.1016/j.jstrokecerebrovasdis.2021.105628. Fulltekst i vitenarkiv Vis sammendrag

  Objectives: To explore factors from the acute phase, and after three and 12 months, associated with level of self-reported physical activity 12 months after a minor ischemic stroke with National Institutes of Health Stroke Scale (NIHSS) score ≤ 3 in persons 70 years or younger. Materials and method: In this longitudinal cohort study patients were recruited consecutively from two stroke units. Activity level were measured with three sets of questions addressing the average number of frequency (times exercising each week), the average intensity, and duration (the average time), and a sum score was constructed. The association between physical activity 12 months after stroke and sociodemographic factors, NIHSS, body mass index, balance, and neuropsychiatric symptoms were explored using multiple linear regression. Results: This study included 101 patients, with mean age (SD) 55.5 (11.4) years, NIHSS median (Q1, Q3) 0.0 (0.0, 1.0), and 20 % were female. Multiple linear regression analyses showed sick leave status at stroke onset, balance at three and 12 months, and anxiety, depression, apathy, and fatigue at 12 months to be factors associated with physical activity at 12 months after stroke. Conclusion: We found that pre-stroke sick leave, post-stroke balance, and neuropsychiatric symptoms were associated with the level of physical activity one year after minor stroke. This might be of importance when giving information about physical activity and deciding about post-stroke follow-up.

• Hamre, Charlotta; Fure, Brynjar; Helbostad, Jorunn L.; Wyller, Torgeir B.; Ihle-Hansen, Hege & Vlachos, Georgios [Vis alle 8 forfattere av denne artikkelen] (2021). Balance and gait after first minor ischemic stroke in people 70 years of age or younger: A prospective observational cohort study. Physical Therapy. ISSN 0031-9023. 100(5), s. 798–806. doi: 10.1093/PTJ/PZAA010. Fulltekst i vitenarkiv
• Ihle-Hansen, Håkon; Sandset, Else Charlotte; Hagberg, Guri & Ihle-Hansen, Hege (2020). Antitrombotisk behandling ved etablert cerebrovaskulær sykdom. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(12), s. 1–2. doi: 10.4045/tidsskr.20.0651.
• Munthe-Kaas, Ragnhild; Aam, Stina; Saltvedt, Ingvild; Wyller, Torgeir Bruun; Pendlebury, Sarah T. & Lydersen, Stian [Vis alle 7 forfattere av denne artikkelen] (2020). Test Accuracy of the Montreal Cognitive Assessment in Screening for Early Poststroke Neurocognitive Disorder. Stroke. ISSN 0039-2499. 52(1), s. 317–320. doi: 10.1161/STROKEAHA.120.031030. Fulltekst i vitenarkiv
• Dørum, Erlend Solberg; Kaufmann, Tobias; Alnæs, Dag; Richard, Geneviève; Kolskår, Knut-Kristian & Engvig, Andreas [Vis alle 11 forfattere av denne artikkelen] (2020). Functional brain network modeling in sub-acute stroke patients and healthy controls during rest and continuous attentive tracking. Heliyon. ISSN 2405-8440. 6:e04854(9), s. 1–11. doi: 10.1016/j.heliyon.2020.e04854. Fulltekst i vitenarkiv
• Kolskår, Knut-Kristian; Richard, Geneviève; Alnæs, Dag; Dørum, Erlend Solberg; Sanders, Anne-Marthe & Ulrichsen, Kristine Moe [Vis alle 10 forfattere av denne artikkelen] (2020). Reliability, sensitivity, and predictive value of fMRI during multiple object tracking as a marker of cognitive training gain in combination with tDCS in stroke survivors. Human Brain Mapping. ISSN 1065-9471. doi: 10.1002/hbm.25284. Fulltekst i vitenarkiv
• Alme, Katinka Nordheim; Knapskog, Anne Brita; Næss, Halvor; Naik, Mala; Beyer, Mona K. & Ellekjær, Hanne [Vis alle 15 forfattere av denne artikkelen] (2020). Is long-bout sedentary behaviour associated with long-Term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study. BMJ Open. ISSN 2044-6055. 10(11), s. 1–9. doi: 10.1136/bmjopen-2020-037475. Fulltekst i vitenarkiv
• Ulrichsen, Kristine Moe; Alnæs, Dag; Kolskår, Knut-Kristian; Richard, Geneviève; Sanders, Anne-Marthe & Dørum, Erlend Solberg [Vis alle 11 forfattere av denne artikkelen] (2020). Dissecting the cognitive phenotype of post-stroke fatigue using computerized assessment and computational modeling of sustained attention. European Journal of Neuroscience. ISSN 0953-816X. 52(7), s. 3828–3845. doi: 10.1111/ejn.14861. Fulltekst i vitenarkiv
• Munthe-Kaas, Ragnhild; Aam, Stina; Ihle-Hansen, Hege; Lydersen, Stian; Knapskog, Anne Brita & Wyller, Torgeir Bruun [Vis alle 15 forfattere av denne artikkelen] (2020). Impact of different methods defining post-stroke neurocognitive disorder: The Nor-COAST study. Alzheimer's and Dementia: Translational Research and Clinical Interventions. ISSN 2352-8737. 6:e12000(1), s. 1–9. doi: 10.1002/trc2.12000. Fulltekst i vitenarkiv
• Richard, Geneviève; Petersen, Anders; Ulrichsen, Kristine Moe; Kolskår, Knut-Kristian; Alnæs, Dag & Sanders, Anne-Marthe [Vis alle 10 forfattere av denne artikkelen] (2020). TVA-based modeling of short-term memory capacity, speed of processing and perceptual threshold in chronic stroke patients undergoing cognitive training: Case-control differences, reliability, and associations with cognitive performance. PeerJ. ISSN 2167-8359. 8:e9948, s. 1–21. doi: 10.7717/peerj.9948. Fulltekst i vitenarkiv
• Aam, Stina; Einstad, Marte Stine; Munthe-Kaas, Ragnhild; Lydersen, Stian; Ihle-Hansen, Hege & Knapskog, Anne Brita [Vis alle 9 forfattere av denne artikkelen] (2020). Post-stroke Cognitive Impairment—Impact of Follow-Up Time and Stroke Subtype on Severity and Cognitive Profile: The Nor-COAST Study. Frontiers in Neurology. ISSN 1664-2295. 11:699, s. 1–10. doi: 10.3389/fneur.2020.00699. Fulltekst i vitenarkiv
• Thommessen, Bente; Næss, Halvor; Logallo, Nicola; Kvistad, Christopher Elnan; Waje-Andreassen, Ulrike & Ihle-Hansen, Hege [Vis alle 9 forfattere av denne artikkelen] (2020). Tenecteplase versus alteplase after acute ischemic stroke at high age. International Journal of Stroke. ISSN 1747-4930. doi: 10.1177/1747493020938306.
• Gynnild, Mari Nordbø; Aakerøy, Rachel; Spigset, Olav; Askim, Torunn; Beyer, Mona Kristiansen & Ihle-Hansen, Hege [Vis alle 15 forfattere av denne artikkelen] (2020). Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke. Journal of Internal Medicine. ISSN 0954-6820. s. 1–14. doi: 10.1111/joim.13161. Fulltekst i vitenarkiv
• Hagberg, Guri; Ihle-Hansen, Hege; Fure, Brynjar; Thommessen, Bente; Ihle-Hansen, Håkon & Øksengård, Anne Rita [Vis alle 11 forfattere av denne artikkelen] (2020). No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - A seven-year follow-up study. BMC Neurology. ISSN 1471-2377. 20, s. 1–11. doi: 10.1186/s12883-020-01753-w. Fulltekst i vitenarkiv
• Hamre, Sophia Charlotta; Fure, Brynjar; Helbostad, Jorunn L.; Wyller, Torgeir Bruun; Ihle-Hansen, Hege & Vlachos, Georgios [Vis alle 8 forfattere av denne artikkelen] (2020). Impairments in spatial navigation during walking in patients 70 years or younger with mild stroke. Topics in Stroke Rehabilitation. ISSN 1074-9357. 27, s. 601–609. doi: 10.1080/10749357.2020.1755814. Fulltekst i vitenarkiv Vis sammendrag

  Background: Spatial navigation, the ability to determine and maintain a route from one place to another, is needed for independence in everyday life. Knowledge about impairments in spatial navigation in people with mild stroke is scarce. Objectives: To explore impairments in spatial navigation in patients ≤70 years after first-ever mild ischemic stroke (NIHSS≤3) and to explore which variables are associated with these impairments 12 months later. Methods: Patients were examined in the acute phase, and after 3 and 12 months. To assess impairments in spatial navigation, we used the Floor Maze Test (FMT), with time and FMT-errors as outcomes. Patients’ perceived navigational skills were collected using self-report. Logistic regression was used to explore which variables (sociodemographic data, stroke characteristics, cognition, and mobility) were associated with impaired navigation ability. Results: Ninety-seven patients (20 females) were included. The mean (SD) age was 55.5 (11.4) years. Timed FMT improved significantly from the acute phase to 12 months (p = <.001). At 12 months, 24 (24.7%) of the participants walked through the maze with errors, and 22 (22.7%) reported spatial navigational problems. The Trail Making Test (TMT)-B was the only variable from the acute phase associated with FMT-errors at 12 months, and being female was the only variable associated with self-reported navigational problems at 12 months. Conclusion: Nearly one in four patients experienced spatial navigation problems 12 months after a mild stroke. Executive function (TMT-B), measured in the acute phase, was associated with navigational impairments (FMT-errors) at 12 months, and being female was associated with self-reported navigational problems

• Døhl, Øystein; Halsteinli, Vidar; Askim, Torunn; Gunnes, Mari; Ihle-Hansen, Hege & Indredavik, Bent [Vis alle 9 forfattere av denne artikkelen] (2020). Factors contributing to post-stroke health care utilization and costs, secondary results from the life after stroke (LAST) study. BMC Health Services Research. ISSN 1472-6963. 20. doi: 10.1186/s12913-020-05158-w. Fulltekst i vitenarkiv
• Vigen, Thea; Ihle-Hansen, Håkon; Lyngbakken, Magnus; Berge, Trygve; Thommessen, Bente & Ihle-Hansen, Hege [Vis alle 11 forfattere av denne artikkelen] (2019). Carotid Atherosclerosis is Associated with Middle Cerebral Artery Pulsatility Index. Journal of Neuroimaging (JON). ISSN 1051-2284. doi: 10.1111/jon.12684. Fulltekst i vitenarkiv
• Richard, Geneviève; Kolskår, Knut-Kristian; Ulrichsen, Kristine Moe; Kaufmann, Tobias; Alnæs, Dag & Sanders, Anne-Marthe [Vis alle 12 forfattere av denne artikkelen] (2019). Brain age prediction in stroke patients: Highly reliable but limited sensitivity to cognitive performance and response to cognitive training. NeuroImage: Clinical. ISSN 2213-1582. 25, s. 1–11. doi: 10.1016/j.nicl.2019.102159. Fulltekst i vitenarkiv
• Vigen, Thea; Ihle-Hansen, Håkon; Lyngbakken, Magnus; Berge, Trygve; Thommessen, Bente & Ihle-Hansen, Hege [Vis alle 12 forfattere av denne artikkelen] (2019). Blood pressure at age 40 predicts carotid atherosclerosis two decades later: Data from the Akershus Cardiac Examination 1950 Study. Journal of Hypertension. ISSN 0263-6352. 37(10), s. 1982–1990. doi: 10.1097/HJH.0000000000002131. Fulltekst i vitenarkiv
• Hagberg, Guri; Fure, Brynjar; Thommessen, Bente; Ihle-Hansen, Håkon; Øksengård, Anne Rita & Nygård, Ståle [Vis alle 10 forfattere av denne artikkelen] (2019). Predictors for Favorable Cognitive Outcome Post-Stroke: A-Seven-Year Follow-Up Study. Dementia and Geriatric Cognitive Disorders. ISSN 1420-8008. s. 1–11. doi: 10.1159/000501850.
• Ihle-Hansen, Hege; Langhammer, Birgitta; Lydersen, Stian; Gunnes, Mari; Indredavik, Bent & Askim, Torunn (2019). A physical activity intervention to prevent cognitive decline after stroke – Secondary results from the LAST (Life After Stroke) study. An 18-month randomised controlled trial. Journal of Rehabilitation Medicine. ISSN 1650-1977. 51(9), s. 646–651. doi: 10.2340/16501977-2588. Fulltekst i vitenarkiv Vis sammendrag

  Objective: To examine the effects of individualized regular coaching and exercise on post-stroke cognitive and emotional function. Methods: The Life After STroke (LAST) study investigated the differences between intervention and care-as-usual between 3 and 21 months post-stroke. Outcome measures were the Trail Making Test (TMT) A and B, Mini Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS), and adherence to the intervention. Results: Of the 362 patients included in the study, 177 were assigned to the intervention. The mean age was 71.7 (SD 11.3) years and 39.5% were female. The adjusted mean difference between groups for TMT A was 8.54 (CI 0.7 to 16.3), p = 0.032, for TMT B 8.6 (CI –16.5 to 33.6), p = 0.50, for MMSE –0.1 (CI –0.8 to 0. 6), p = 0.77, for HADS A –0.2 (CI –0.9 to 0.5), p = 0.56 and for HADS D –0.1 (CI –0.7 to 0.5), p = 0.76). A higher level of adherence to the intervention was significantly associated with increased MMSE (B = 0.030 (CI 0.005–0.055), p = 0.020) Conclusion: No clinically relevant effects on cognitive or emotional function were found of individualized regular coaching for physical activity and exercise. However, increased adherence to the intervention was associated with improved cognitive function.

• Krishnan, Kailash; Bassilious, Kerolos; Eriksen, Erik; Bath, Philip M.; Sprigg, Nikola & Brækken, Sigrun Kierulf [Vis alle 9 forfattere av denne artikkelen] (2019). Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review. European Stroke Journal. ISSN 2396-9873. s. 1–7. doi: 10.1177/2396987319843701.
• Gunnes, Mari; Indredavik, Bent; Langhammer, Birgitta; Lydersen, Stian; Ihle-Hansen, Hege & Dahl, Anne Eitrem [Vis alle 7 forfattere av denne artikkelen] (2019). Associations Between Adherence to the Physical Activity and Exercise Program Applied in the LAST Study and Functional Recovery After Stroke. Archives of Physical Medicine and Rehabilitation. ISSN 0003-9993. s. 1–9. doi: 10.1016/j.apmr.2019.04.023. Fulltekst i vitenarkiv
• Ihle-Hansen, Håkon; Vigen, Thea; Berge, Trygve; Hagberg, Guri; Engedal, Knut & Rønning, Ole M. [Vis alle 12 forfattere av denne artikkelen] (2019). Carotid Atherosclerosis and Cognitive Function in a General Population Aged 63-65 Years: Data from the Akershus Cardiac Examination (ACE) 1950 Study. Journal of Alzheimer's Disease. ISSN 1387-2877. 70(4), s. 1041–1049. doi: 10.3233/JAD-190327. Fulltekst i vitenarkiv
• Efjestad, Anne; Ihle-Hansen, Hege; Hjellvik, Vidar; Engedal, Knut & Blix, Hege Salvesen (2019). Drug Use before and after Initiating Treatment with Acetylcholinesterase Inhibitors. Dementia and Geriatric Cognitive Disorders Extra. ISSN 1664-5464. 9(1), s. 196–206. doi: 10.1159/000497307. Fulltekst i vitenarkiv
• Langhammer, Birgitta; Ada, Louise; Gunnes, Mari; Ihle-Hansen, Hege; Indredavik, Bent & Askim, Torunn (2019). A physical activity program is no more effective than standard care at maintaining upper limb activity in community-dwelling people with stroke: secondary outcomes from a randomized trial. Clinical Rehabilitation. ISSN 0269-2155. 33(10), s. 1607–1613. doi: 10.1177/0269215519856048. Fulltekst i vitenarkiv
• Hagberg, Guri; Fure, Brynjar; Sandset, Else Charlotte; Thommessen, Bente; Ihle-Hansen, Håkon & Øksengård, Anne Rita [Vis alle 9 forfattere av denne artikkelen] (2019). Long-term effects on survival after a 1-year multifactorial vascular risk factor intervention after stroke or TIA: Secondary analysis of a randomized controlled trial, a 7-year follow-up study. Vascular Health and Risk Management. ISSN 1176-6344. 15, s. 11–18. doi: 10.2147/VHRM.S191873. Fulltekst i vitenarkiv
• Ratajczak-Tretel, Barbara; Lambert, Anna Tancin; Johansen, Henriette; Halvorsen, Bente; Bjerkeli, Vigdis & Russell, David [Vis alle 37 forfattere av denne artikkelen] (2019). Atrial fibrillation in cryptogenic stroke and transient ischaemic attack – The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Rationale and design. European Stroke Journal. ISSN 2396-9873. 4(2), s. 172–180. doi: 10.1177/2396987319837089. Fulltekst i vitenarkiv
• Gunnes, Mari; Langhammer, Birgitta; Aamot, Inger Lise; Lydersen, Stian; Ihle-Hansen, Hege & Indredavik, Bent [Vis alle 9 forfattere av denne artikkelen] (2019). Adherence to a Long-Term Physical Activity and Exercise Program After Stroke Applied in a Randomized Controlled Trial. Physical Therapy. ISSN 0031-9023. 99(1), s. 74–85. doi: 10.1093/ptj/pzy126. Fulltekst i vitenarkiv
• Thingstad, Pernille; Askim, Torunn; Beyer, Mona K.; Bråthen, Geir; Ellekjær, Hanne & Ihle-Hansen, Hege [Vis alle 13 forfattere av denne artikkelen] (2018). The Norwegian Cognitive impairment after stroke study (Nor-COAST): study protocol of a multicentre, prospective cohort study. BMC Neurology. ISSN 1471-2377. 18:193. doi: 10.1186/s12883-018-1198-x. Fulltekst i vitenarkiv
• Teuschl, Yvonne; Ihle-Hansen, Hege; Matz, Karl; Dachenhausen, Alexandra; Ratajczak, Paulina & Tuomilehto, Jaakko [Vis alle 11 forfattere av denne artikkelen] (2018). Multidomain intervention for the prevention of cognitive decline after stroke ? a pooled patient-level data analysis. European Journal of Neurology. ISSN 1351-5101. 25(9), s. 1182–1188. doi: 10.1111/ene.13684.
• Ursin, Marie Helene; Bergland, Astrid; Fure, Brynjar; Thommessen, Bente; Hagberg, Guri & Øksengård, Anne Rita [Vis alle 7 forfattere av denne artikkelen] (2018). Gait and balance one year after stroke; relationships with lesion side, subtypes of cognitive impairment and neuroimaging findings-a longitudinal, cohort study. Physiotherapy. ISSN 0031-9406. doi: 10.1016/j.physio.2018.07.007. Fulltekst i vitenarkiv
• Kvistad, Christopher Elnan; Novotny, Vojtech; Næss, Halvor; Hagberg, Guri; Ihle-Hansen, Hege & Waje-Andreassen, Ulrike [Vis alle 8 forfattere av denne artikkelen] (2018). Safety and predictors of stroke mimics in The Norwegian Tenecteplase Stroke Trial (NOR-TEST). International Journal of Stroke. ISSN 1747-4930. s. 1–9. doi: 10.1177/1747493018790015.
• Ihle-Hansen, Håkon; Vigen, Thea; Ihle-Hansen, Hege; Rønning, Ole M.; Berge, Trygve & Thommessen, Bente [Vis alle 12 forfattere av denne artikkelen] (2018). Prevalence of carotid plaque in a 63- to 65-Year-Old Norwegian cohort from the general population: The ACE (Akershus Cardiac Examination) 1950 study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 7(10). doi: 10.1161/JAHA.118.008562. Fulltekst i vitenarkiv
• Askim, Torunn; Gunnes, Mari; Ihle-Hansen, Hege; Langhammer, Birgitta; Lydersen, Stian & Indredavik, Bent [Vis alle 34 forfattere av denne artikkelen] (2017). Efficacy and Safety of Individualized Coaching After Stroke: the LAST Study (Life After Stroke) A Pragmatic Randomized Controlled Trial. Stroke. ISSN 0039-2499. doi: 10.1161/STROKEAHA.117.018827.
• Fisher, James Michael; Masud, Tahir; Holm, Ellen Astrid; Roller-Wirnsberger, Regina Elisabeth; Stuck, Andreas Ernst & Gordon, Adam [Vis alle 28 forfattere av denne artikkelen] (2017). New horizons in geriatric medicine education and training: The need for pan-European education and training standards. European Geriatric Medicine. ISSN 1878-7649. 8(5-6), s. 467–473. doi: 10.1016/j.eurger.2017.07.022.
• Ihle-Hansen, Håkon; Vigen, Thea; Berge, Trygve; Einvik, Gunnar; Aarsland, Dag & Rønning, Ole M. [Vis alle 10 forfattere av denne artikkelen] (2017). Montreal Cognitive Assessment in a 63- to 65-year-old Norwegian Cohort from the General Population: Data from the Akershus Cardiac Examination 1950 Study. Dementia and Geriatric Cognitive Disorders Extra. ISSN 1664-5464. 7(3), s. 318–327. doi: 10.1159/000480496. Fulltekst i vitenarkiv
• Askim, Torunn; Langhammer, Birgitta; Ihle-Hansen, Hege; Gunnes, Marit; Lydersen, Stian & Indredavik, Bent [Vis alle 34 forfattere av denne artikkelen] (2017). Efficacy and Safety of Individualized Coaching After Stroke: the LAST Study (Life After Stroke): A Pragmatic Randomized Controlled Trial. Stroke. ISSN 0039-2499. 49(2), s. 426–432. doi: 10.1161/STROKEAHA.117.018827. Fulltekst i vitenarkiv
• Logallo, Nicola; Novotny, Vojtech; Assmus, Jörg; Kvistad, Christopher Elnan; Alteheld, Lars Holger & Rønning, Ole M. [Vis alle 21 forfattere av denne artikkelen] (2017). Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial. Lancet Neurology. ISSN 1474-4422. 16(10), s. 781–788. doi: 10.1016/S1474-4422(17)30253-3.
• Ihle-Hansen, Hege; Hagberg, Guri; Fure, Brynjar; Thommessen, Bente; Fagerland, Morten & Øksengård, Anne Rita [Vis alle 8 forfattere av denne artikkelen] (2017). Association between total-Tau and brain atrophy one year after first-ever stroke. BMC Neurology. ISSN 1471-2377. 17. doi: 10.1186/s12883-017-0890-6. Fulltekst i vitenarkiv
• Efjestad, Anne; Ihle-Hansen, Hege; Hjellvik, Vidar & Blix, Hege Salvesen (2017). Comedication and treatment length in users of acetylcholinesterase inhibitors. Dementia and Geriatric Cognitive Disorders Extra. ISSN 1664-5464. 7(1), s. 30–40. doi: 10.1159/000454948. Fulltekst i vitenarkiv
• Loureiro C, Ana Paula; Langhammer, Birgitta; Gjøvaag, Terje; Ihle-Hansen, Hege & Guarita-Souza, LC (2017). Skeletal muscle metabolism after stroke: a comparative study using treadmill and overground walking test. Journal of Rehabilitation Medicine. ISSN 1650-1977. 49(7), s. 558–564. doi: 10.2340/16501977-2255.
• Mijajlović, Milija D.; Pavlović, Aleksandra; Brainin, Michael; Heiss, Wolf-Dieter; Quinn, Terence J. & Ihle-Hansen, Hege [Vis alle 33 forfattere av denne artikkelen] (2017). Post-stroke dementia - a comprehensive review. BMC Medicine. ISSN 1741-7015. 15:11(1), s. 1–12. doi: 10.1186/s12916-017-0779-7.

Se alle arbeider i Cristin

• Ihle-Hansen, Hege Beate & Solberg, Carl Tollef (2023). Prioriteringer i helsetjenesten .
• Rønning, Ole Morten; Carlsson, Maria Kristin; Ihle-Hansen, Hege; Aamodt, Anne Hege ; Tveiten, Arnstein & Eltoft, Agnethe [Vis alle 9 forfattere av denne artikkelen] (2022). Overvåkning etter akutt hjerneslag bør bli bedre. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(14), s. 1–6. doi: 10.4045/tidsskr.22.0401.
• Ihle-Hansen, Hege; Kelly, Peter; Bladin, Christopher & Chaturvedi, Seemant (2022). Editorial: Emerging Areas in Extracranial Carotid Stenosis Evaluation and Management. Frontiers in Neurology. ISSN 1664-2295. 13. doi: 10.3389/fneur.2022.891883.
• Bugge, Helge Fagerheim; Guterud, Mona; Bache, Kristi Cecilie Grønvold; Braarud, Anne-Cathrine ; Eriksen, Erik & Fremstad, Kjell Otto [Vis alle 15 forfattere av denne artikkelen] (2022). Paramedic Norwegian Acute Stroke Prehospital Project (ParaNASPP) study protocol: a stepped wedge randomised trial of stroke screening using the National Institutes of Health Stroke Scale in the ambulance. Trials. ISSN 1745-6215. 23(1). doi: 10.1186/s13063-022-06006-4. Fulltekst i vitenarkiv
• Larsson, Petra; Skogestad, Ingrid Johansen; Edvardsen, Elisabeth; Gay, Caryl; Ursin, Marie Helene & Mack, Ulrich [Vis alle 9 forfattere av denne artikkelen] (2021). Association between fatigue and physical fitness three months after stroke.
• Ihle-Hansen, Håkon; Sandset, Else Charlotte; Ihle-Hansen, Hege; Hagberg, Guri; Thommessen, Bente & Rønning, Ole Morten [Vis alle 12 forfattere av denne artikkelen] (2021). Sex differences in the Norwegian Tenecteplase Trial (NOR-TEST). European Journal of Neurology. ISSN 1351-5101. 29, s. 609–614. doi: 10.1111/ene.15126. Fulltekst i vitenarkiv
• Nerdal, Vilde; Gjestad, Elise Ødegård; Saltvedt, Ingvild; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege & Ryum, Truls [Vis alle 8 forfattere av denne artikkelen] (2021). The Relationship of Acute Delirium with Cognitive and Psychiatric Symptoms After Stroke: A Longitudinal Study.
• Larsen, Kristin Tveitan; Forfang, Elisabeth; Pennlert, Johanna; Glader, Eva-Lotta; Kruuse, Christina & Wester, Per [Vis alle 12 forfattere av denne artikkelen] (2020). STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage: Protocol for a randomised controlled trial. European Stroke Journal. ISSN 2396-9873. 5(4), s. 414–422. doi: 10.1177/2396987320954671. Fulltekst i vitenarkiv
• Lambert, Anna Tancin; Ratajczak-Tretel, Barbara; Halvorsen, Bente; Bjerkeli, Vigdis; Russell, David & Sandset, Else Charlotte [Vis alle 25 forfattere av denne artikkelen] (2019). Clinically available biomarkers as predictors of atrial fibrillation in patients with cryptogenic stroke the Nordic Atrial Fibrillation and Stroke Study (NOR-FIB) . European Journal of Neurology. ISSN 1351-5101. 26, s. 90–90.
• Ratajczak-Tretel, Barbara; Lambert, Anna Tancin; Johansen, H; Halvorsen, Bente; Russell, David & Sandset, Else Charlotte [Vis alle 24 forfattere av denne artikkelen] (2019). Hunting for the underlying causes and links: Atrial fibrillation in cryptogenic stroke and TIA - The Nordic atrial fibrillation and stroke study (NOR-FIB). .
• Langhammer, Birgitta; Gunnes, Mari; Ihle-Hansen, Hege; Indredavik, Bent & Askim, Torunn (2019). Physical activity influence on arm and hand function post stroke.
• Knudtzon, Stephanie; Lane, Leon Andrew; Melhuus, Knut & Ihle-Hansen, Hege (2018). Hjerneslag etter opphold av direktevirkende antikoagulasjonsmidler . Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(8), s. 706–707. doi: 10.4045/tidsskr.18.0313.
• Munthe-Kaas, Ragnhild; Aam, Stina; Saltvedt, Ingvild; Thingstad, Pernille; Askim, Torunn & Beyer, Mona K. [Vis alle 14 forfattere av denne artikkelen] (2018). The burden of post-stroke cognitive impairments in a Norwegian stroke population (Nor-COAST).
• Aam, Stina; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege; Knapskog, Anne Brita & Saltvedt, Ingvild (2018). Classifying cognitive impairment after stroke - The Nor-COAST study.
• Ihle-Hansen, Hege & Wyller, Torgeir Bruun (2017). Re: Akutte nevrologer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(4), s. 260–260. doi: 10.4045/tidsskr.17.0102.
• Askim, Torunn; Langhammer, Birgitta; Ihle-Hansen, Hege; Gunnes, Marit; Lydersen, Stian & Indredavik, Bent (2017). Efficacy and safety of an individualised intervention programme with regular coaching on physical activity and exercise after stroke (LAST study). An 18-month multi-site randomised controlled trial.
• Gunnes, Mari; Langhammer, Birgitta; Aamot, Inger Lise; Lydersen, Stian; Ihle-Hansen, Hege & Indredavik, Bent [Vis alle 9 forfattere av denne artikkelen] (2017). How well do stroke survivors adhere to an 18-month physical activity and exercise programme? Secondary results form a randomized controlled trial.
• Gunnes, Mari; Langhammer, Birgitta; Aamot, Inger Lise; Lydersen, Stian; Ihle-Hansen, Hege & Indredavik, Bent [Vis alle 9 forfattere av denne artikkelen] (2017). Adherence to a long-term physical activity and exercise programme after stroke applied in a randomized controlled trial.

Se alle arbeider i Cristin