Paul Remy Jones

• Howe, Laurence J; Rasheed, Humaira; Jones, Paul Remy; Boomsma, Dorret I; Evans, David M & Giannelis, Alexandros [Vis alle 46 forfattere av denne artikkelen] (2023). Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study. International Journal of Epidemiology. ISSN 0300-5771. 52(5), s. 1579–1591. doi: 10.1093/ije/dyad079. Fulltekst i vitenarkiv
• Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein & Anderssen, Sigmund Alfred [Vis alle 10 forfattere av denne artikkelen] (2022). Associations of lipoprotein particle profile and objectively measured physical activity and sedentary time in schoolchildren: a prospective cohort study. International Journal of Behavioral Nutrition and Physical Activity. ISSN 1479-5868. 19(1). doi: 10.1186/s12966-022-01244-w. Fulltekst i vitenarkiv Vis sammendrag

  Background: Our understanding of the mechanisms through which physical activity might benefit lipoprotein metabolism is inadequate. Here we characterise the continuous associations between physical activity of different intensities, sedentary time, and a comprehensive lipoprotein particle profile. Methods: Our cohort included 762 fifth grade (mean [SD] age = 10.0 [0.3] y) Norwegian schoolchildren (49.6% girls) measured on two separate occasions across one school year. We used targeted proton nuclear magnetic resonance (1H NMR) spectroscopy to produce 57 lipoprotein measures from fasted blood serum samples. The children wore accelerometers for seven consecutive days to record time spent in light-, moderate-, and vigorous-intensity physical activity, and sedentary time. We used separate multivariable linear regression models to analyse associations between the device-measured activity variables—modelled both prospectively (baseline value) and as change scores (follow-up minus baseline value)—and each lipoprotein measure at follow-up. Results: Higher baseline levels of moderate-intensity and vigorous-intensity physical activity were associated with a favourable lipoprotein particle profile at follow-up. The strongest associations were with the larger subclasses of triglyceride-rich lipoproteins. Sedentary time was associated with an unfavourable lipoprotein particle profile, the pattern of associations being the inverse of those in the moderate-intensity and vigorous-intensity physical activity analyses. The associations with light-intensity physical activity were more modest; those of the change models were weak. Conclusion: We provide evidence of a prospective association between time spent active or sedentary and lipoprotein metabolism in schoolchildren. Change in activity levels across the school year is of limited influence in our young, healthy cohort.

• Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein & Anderssen, Sigmund Alfred [Vis alle 10 forfattere av denne artikkelen] (2021). Cross-sectional and prospective associations between aerobic fitness and lipoprotein particle profile in a cohort of Norwegian schoolchildren. Atherosclerosis. ISSN 0021-9150. 321, s. 21–29. doi: 10.1016/j.atherosclerosis.2021.02.002. Fulltekst i vitenarkiv
• Jones, Paul Remy & Ekelund, Ulf (2019). Physical activity in the prevention of weight gain: the impact of measurement and interpretation of associations. Current Obesity Reports. ISSN 2162-4968. 8(2), s. 66–76. doi: 10.1007/s13679-019-00337-1. Fulltekst i vitenarkiv Vis sammendrag

  Purpose of Review: To what extent do different methods of physical activity measurement and statistical analysis influence the reported associations between physical activity and weight gain? Recent Findings: The obesity epidemic has led to a focus on lifestyle approaches to the prevention of weight gain. Physical activity is one such approach. A number of studies have reported beneficial associations between higher levels of physical activity and weight gain at the population level. However, limitations of physical activity measurement and analytical models in some of these studies are likely to have resulted in overestimation of the strength of association. Summary: Understanding the limitations of assessment methods and analytical models used in epidemiological research should facilitate more realistic appraisal for physical activity to prevent weight gain at the population level and inform approaches to future research.

• Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein & Anderssen, Sigmund Alfred [Vis alle 10 forfattere av denne artikkelen] (2019). Associations of physical activity and sedentary time with lipoprotein subclasses in Norwegian schoolchildren: The Active Smarter Kids (ASK) study. Atherosclerosis. ISSN 0021-9150. 288, s. 186–193. doi: 10.1016/j.atherosclerosis.2019.05.023. Fulltekst i vitenarkiv Vis sammendrag

  Background and aims: Physical activity is favourably associated with certain markers of lipid metabolism. The relationship of physical activity with lipoprotein particle profiles in children is not known. Here we examine cross-sectional associations between objectively measured physical activity and sedentary time with serum markers of lipoprotein metabolism. Methods: Our cohort included 880 children (49.0% girls, mean age 10.2 years). Physical activity intensity and time spent sedentary were measured objectively using accelerometers. 30 measures of lipoprotein metabolism were quantified using nuclear magnetic resonance spectroscopy. Multiple linear regression models adjusted for age, sex, sexual maturity and socioeconomic status were used to determine associations of physical activity and sedentary time with lipoprotein measures. Additional models were adjusted for adiposity. Isotemporal substitution models quantified theoretical associations of replacing 30 min of sedentary time with 30 min of moderate- to vigorous-intensity physical activity (MVPA). Results: Time spent in MVPA was associated with a favourable lipoprotein profile independent of sedentary time. There were inverse associations with a number of lipoprotein measures, including most apolipoprotein B-containing lipoprotein subclasses and triglyceride measures, the ratio of total to high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol concentration. There were positive associations with larger HDL subclasses, HDL cholesterol concentration and particle size. Reallocating 30 min of sedentary time to MVPA had broadly similar associations. Sedentary time was only partly and weakly associated with an unfavourable lipoprotein profile. Conclusions: Physical activity of at least moderate-intensity is associated with a favourable lipoprotein profile in schoolchildren, independent of time spent sedentary, adiposity and other confounders.

Se alle arbeider i Cristin

• Næss, Øyvind Erik & Jones, Paul Remy (2021). Sosiale ulikheter i helse – før, under og etter pandemien. Michael. ISSN 1893-9651.
• Sainani, Kristin L.; Lohse, Keith R.; Jones, Paul Remy & Vickers, Andrew (2019). Magnitude‐based Inference is not Bayesian and is not a valid method of inference. Scandinavian Journal of Medicine & Science in Sports. ISSN 0905-7188. 29(9), s. 1428–1436. doi: 10.1111/sms.13491.

Se alle arbeider i Cristin