Abstract
In this project the Melum lab will apply cutting-edge sequencing-based methods and 3D immunohistochemistry histology alongside organoid co-cultures and murine experimental models to pinpoint the key interactions that leads to destruction of the bile ducts. Our approach of combining unbiased, high-resolution multiomics with robust functional approaches will greatly improve upon previous efforts and aims to define the important biological networks underlying biliary inflammation which are amendable to intervention.