News - Page 4

Sean Harrison, Saphira Baumgarten and Gareth Sullivan have published a review in Frontiers in Medicine that summarizes the current state of Liver Organoids

Dr. Håkon Høgset is joining the Krauss lab. at the HTH- Centre of Excellence as a Marie Curie post-doctoral fellow.

The new article from the Scholz group highlights the importance of working multidisciplinary for beta-cell replacement therapy in Norway. 

Members of the Hybrid Technology Hub have demonstrated a new approach for mapping drug metabolism in organoids.

LagLivLab er et verksted med avansert utstyr for å bygge lab-brikker.

Gareth Sullivan has co-authored a perspective article of how current brain organoid models recapitulate the brain in many facets.  

Gareth Sullivan has co-authored a publication in an ongoing collaboration. The paper describes generation of hiPSCs from two POLG patients and differentiation into DA neurons to establish a disease model to elucidate mechanisms involved in neuronal dysfunction caused by POLG mutations and to examine the pathological role of ROS in this process.

Project abstract:

New review article in Current Diabetes Reports by HTH reseachers summarizing the current progress and possibilities of using pancreas-on-a-chip (PoC) technology as a tool in clinical islet transplantation.

Two Hybrid Technology Hub projects: DUCT chip – An artificial bile duct on a chip recapitulating immune functions and Tankyrase inhibition as a therapeutic principle in idiopathic lung fibrosis have received innovation funding from the University of Oslo for early phase support. 

Hanne Scholz and her collaborators within the Oxford Consortium for Islet Transplantation have co-authored a new article in Cell Transplantation on the proteomic profiling of the mesenchymal stem cell secretome. 

Alexandre Corthay and his PhD-student Astri Frafjord have studied the body's immune response towards human lung cancer, and developed a new method to identify and quantify which types of immune cells are present inside tumors. Data from this research will serve as a basis for designing the cellular content for the coming "tumor-on-a-chip".

Hybrid Technology Hub PI Gareth Sullivan have co-authored a new paper on cardiac differentiation in Scientific Reports.

This month Kristine Dolva joined the Hybrid Technology Hub - Center for Organ on a Chip-technology. Kristine will work on the development of a "Heart-fibre-on-chip"-system to allow physiological media recirculation in the microfluidic system.

As a part of the CompSci doctral programme funded by HORIZON2020, Hanne Scholz and Dag Kristian Dysthe will lead a project on deep-learning based analysis and modelling of stem cell differentiation pathways. The project will hire one PhD-student, and is closely related to the ABINO Convergence enviroment.

Hanne Scholz co-authored a paper on Placenta-derived Cell Therapy for COVID-19 pasients with acute respiratory distress syndrome (ARDS).

Gareth Sullivan has co-authored a paper in an ongoing collaboration. The paper demonstrates the recapitulation of both neuronal molecular and biochemical defects associated with POLG mutation in a human stem cell model. Furthermore, we provide insight into how mitochondrial dysfunction and mtDNA alterations influence cellular fate determining processes.

Cécile Echalier joined the Hybrid Technology Hub – Centre for Organ on a Chip Technology – in February. She was awarded an outgoing Scientia fellowship to develop an islets-on-chip platform with integrated biosensors.

Justyna Stokowiec is the principal engineer at The Hybrid Technology Hub Core Facility. Justyna will be responsible for handling, delivering and quality control of the induced pluripotent stemcells, as well as the daily running of the core facility laboratory.

Centre PI Professor Jan Helge Solbakk, with centre director Professor Stefan Krauss as partner were successfully awarded funding from the EU Horizon 2020;  Science with and for Society-program (SwafS) with the project The ethics of organoids (HYBRIDA). The project is granted 3,0 million EURO and the project period is three years (2021-2023).

This semester, three master students involved in HTH and Organ-on-a-chip-projects submitted their master thesis. The students graduated from the Department of Chemistry, UiO and they all recieved the grade A!

Jo Waaler and Stefan Krauss published an article on the chemical synthesis of a novel tankyrase inhibitor series. Tankyrase1/2 is a central biotarget at the cross road between WNT/YAP and PGC-1a signaling with implications in tissue differentiation and a broad spectrum of diseases.