Academic interests
Impact of axonal functions on neuronal network activities.
Plasticity and regulation of GABAergic inhibition.
Current research
Functional analysis of cortical interneuron axons. Inhibitory interneurons play a key role in several higher microcircuit functions, such as feedforward and feedback inhibition, high-frequency network oscillations, and temporal encoding of information in the brain. Many of these functions are critically dependent on the rapid and temporally precise release of GABA from inhibitory axon terminals. We study the mechanisms in these interneuron axons that are underlying the fast signalling.
Background
2021– Principal Investigator, Synaptic physiology, University of Oslo
2016–2021 Postdoc, Synaptic physiology, University of Oslo
2009–2016 PhD student, Neurophysiology, University of Heidelberg
Partners
Andreas Draguhn, Heidelberg
Ethan Goldberg, Philadelphia
Awards
2021 RCN FRIPRO Researcher grant, young talents
2016 Scientia fellows Marie Sklodowska-Curie postdoctoral fellowship
Tags:
Brain and nervous system,
Cellular and subcellular electrophysiology,
Axon physiology,
Neuronal network oscillations
Selected publications
Roth, F. C., and Hu, H. (2020). An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons. Nature Communications, 11, 2248.
Thome, C., Roth, F. C., Obermayer, J., Yanez, A., Draguhn, A., Egorov, A. V. (2018). Synaptic entrainment of ectopic action potential generation in hippocampal pyramidal neurons. Journal of Physiology, 596(21), 5237-5249
Hu, H., Roth, F. C., Vandael, D., Jonas, P. (2018). Complementary Tuning of Na+ and K+ Channel Gating Underlies Fast and Energy-Efficient Action Potentials in GABAergic Interneuron Axons. Neuron, 98(1), 156–165.e6.
Roth, F. C., Beyer, K. M., Both, M., Draguhn, A., Egorov, A. V. (2016) Downstream effects of hippocampal sharp wave ripple oscillations on medial entorhinal cortex layer V neurons in vitro. Hippocampus, 26(12), 1493–1508.
Hick, M., Herrmann, U., Weyer, S. W., Mallm, J.-P., Tschäpe, J.-A., Borgers, M., Mercken, M., Roth, F. C., Draguhn, A., Slomianka, L., Wolfer, D. P., Korte, M., Müller, U. C. (2015). Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity. Acta Neuropathol, 129(1), 21–37.
Nordström, V., Willershäuser, M., Herzer, S., Rozman, J., Bohlen und Halbach, von, O., Meldner, S., Rothermel, U., Kaden, S. Roth, F. C., Waldeck, C., Gretz, N., de Angelis, M.H., Draguhn, A., Klingenspor, M., Gröne, H.-J., Jennemann, R. (2013). Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis. PLoS Biol., 11(3), e1001506.
Roth, F. C. & Draguhn, A. (2012). GABA Metabolism and Transport: Effects on Synaptic Efficacy. Neural Plasticity, 2012, 805830.
Reichinnek, S., Kameke, von, A., Hagenston, A. M., Freitag, E., Roth, F. C., Bading, H., et al. (2012). Reliable optical detection of coherent neuronal activity in fast oscillating networks in vitro. NeuroImage, 60(1), 139–152.
Roth, F. C., & Laberge, F. (2011). High convergence of olfactory and vomeronasal influence in the telencephalon of the terrestrial salamander Plethodon shermani. Neuroscience, 177, 148–158.
Published
Nov. 10, 2017 3:59 PM
- Last modified
Sep. 23, 2021 1:55 PM
