Jerome Nicolas Marius Ruzzin

Persistent organic pollutants disrupt the oxidant/antioxidant balance of INS-1E pancreatic β-cells causing their physiological dysfunctions. Environment International 2024 . Impact Factor: 11.8

Mice lacking intestinal Nr1i2 have normal intestinal homeostasis under steady-state conditions and are not hypersensitive to inflammation under lipopolysaccharide treatment. FASEB Journal 2023 - Impact Factor: 5.83

Associations between persistent organic pollutants and type 1 diabetes in youth. Environment International 2022 . Impact Factor: 13.35

Treatment with fibroblast growth factor 19 increases skeletal muscle fiber size, ameliorates metabolic perturbations and hepatic inflammation in 5/6 nephrectomized mice. Science Reports 2023 - Impact factor: 4.99 

Fibroblast growth factor 19 as a countermeasure to muscle and locomotion dysfunctions in experimental cerebral palsy. Journal of Cachexia, Sarcopenia and Muscle 2021 - Impact Factor: 12.91

Fibroblast growth factor 19 regulates skeletal muscle mass and protects from muscle wasting. Nature Medicine 2017 - Impact Factor: 32.62

Environmental Health Perspectives (2010), PLoS ONE (2011), Journal of Clinical Endocrinology & Metabolism (2014). 

• Bresson, Sophie Emilie & Ruzzin, Jerome Nicolas Marius (2024). Persistent organic pollutants disrupt the oxidant/antioxidant balance of INS-1E pancreatic β-cells causing their physiological dysfunctions. Environment International. ISSN 0160-4120. 190. doi: 10.1016/j.envint.2024.108821.
• Amini, Salah Edden; Bresson, Sophie Emilie & Ruzzin, Jerome Nicolas Marius (2023). Mice lacking intestinal Nr1i2 have normal intestinal homeostasis under steady-state conditions and are not hypersensitive to inflammation under lipopolysaccharide treatment. The FASEB Journal. ISSN 0892-6638. 37(8). doi: 10.1096/fj.202301126. Full text in Research Archive
• Benoit, Berengère; Beau, Alice; Bres, Émilie; Chanon, Stéphanie; Pinteur, Claudie & Vieille-Marchiset, Aurélie [Show all 14 contributors for this article] (2023). Treatment with fibroblast growth factor 19 increases skeletal muscle fiber size, ameliorates metabolic perturbations and hepatic inflammation in 5/6 nephrectomized mice. Scientific Reports. ISSN 2045-2322. 13. doi: 10.1038/s41598-023-31874-4. Full text in Research Archive
• Bresson, Sophie Emilie; Isom, Scott; Jensen, ET; Huber, Sandra; Oulhote, Youssef & Rigdon, Joseph [Show all 12 contributors for this article] (2022). Associations between persistent organic pollutants and type 1 diabetes in youth. Environment International. ISSN 0160-4120. 163. doi: 10.1016/j.envint.2022.107175. Full text in Research Archive Show summary

  Background: Diabetes affects millions of people worldwide with a continued increase in incidence occurring within the pediatric population. The potential contribution of persistent organic pollutants (POPs) to diabetes in youth remains poorly known, especially regarding type 1 diabetes (T1D), generally the most prevalent form of diabetes in youth. Objectives: We investigated the associations between POPs and T1D in youth and studied the impacts of POPs on pancreatic β-cell function and viability in vitro. Methods: We used data and plasma samples from the SEARCH for Diabetes in Youth Case Control Study (SEARCH-CC). Participants were categorized as Controls, T1D with normal insulin sensitivity (T1D/IS), and T1D with insulin resistance (T1D/IR). We assessed plasma concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides and estimated the odds of T1D through multivariable logistic regression. In addition, we performed in vitro experiments with the INS-1E pancreatic β-cells. Cells were treated with PCB-153 or p,p’- DDE at environmentally relevant doses. We measured insulin production and secretion and assessed the mRNA expression of key regulators involved in insulin synthesis (Ins1, Ins2, Pdx1, Mafa, Pcsk1/3, and Pcsk2), glucose sensing (Slc2a2 and Gck), and insulin secretion (Abcc8, Kcnj11, Cacna1d, Cacna1b, Stx1a, Snap25, and Sytl4). Finally, we assessed the effects of PCB-153 and p,p’-DDE on β-cell viability. Results: Among 442 youths, 112 were controls, 182 were classified with T1D/IS and 148 with T1D/IR. The odds ratios (OR) of T1D/IS versus controls were statistically significant for p,p’-DDE (OR 2.0, 95% confidence interval (CI) 1.0, 3.8 and 2.4, 95% CI 1.2, 5.0 for 2nd and 3rd tertiles, respectively), trans-nonachlor (OR 2.5, 95% CI 1.3, 5.0 and OR 2.3, 95% CI 1.1, 5.1 for 2nd and 3rd tertiles, respectively), and PCB-153 (OR 2.3, 95% CI 1.1, 4.6 for 3rd tertile). However, these associations were not observed in participants with T1D/IR. At an experimental level, treatment with p,p’-DDE or PCB-153, at concentrations ranging from 1 × 10-15 M to 5 × 10-6 M, impaired the ability of pancreatic β-cells to produce and secrete insulin in response to glucose. These failures were par- alleled by impaired Ins1 and Ins2 mRNA expression. In addition, among different targeted genes, PCB-153 significantly reduced Slc2a2 and Gck mRNA expression whereas p,p’-DDE mainly affected Abcc8 and Kcnj11. While treatment with PCB-153 or p,p’-DDE for 2 days did not affect β-cell viability, longer treatment progres- sively killed the β-cells

• Pereira, Sabrina da Conceição; Benoit, Bérengère; de Aguiar Junior, Francisco Carlos Amanajás; Chanon, Stéphanie; Vieille-Marchiset, Aurélie & Pesenti, Sandra [Show all 9 contributors for this article] (2021). Fibroblast growth factor 19 as a countermeasure to muscle and locomotion dysfunctions in experimental cerebral palsy. Journal of Cachexia, Sarcopenia and Muscle. ISSN 2190-5991. 12(6), p. 2122–2133. doi: 10.1002/jcsm.12819. Full text in Research Archive
• Dusanov, Sasa; Svendsen, Mette; Ruzzin, Jerome; Kiviranta, Hannu; Gulseth, Hanne Løvdal & Klemsdal, Tor Ole [Show all 7 contributors for this article] (2019). Effect of fatty fish or nut consumption on concentrations of persistent organic pollutants in overweight or obese men and women: A randomized controlled clinical trial. NMCD. Nutrition Metabolism and Cardiovascular Diseases. ISSN 0939-4753. 30(3), p. 448–458. doi: 10.1016/j.numecd.2019.11.006. Full text in Research Archive
• Dusanov, Sasa; Ruzzin, Jérôme; Kiviranta, Hannu; Klemsdal, Tor Ole; Retterstøl, Lars & Rantakokko, Panu [Show all 9 contributors for this article] (2018). Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals. NMCD. Nutrition Metabolism and Cardiovascular Diseases. ISSN 0939-4753. p. 1–8. doi: 10.1016/j.numecd.2018.03.004.
• Benoit, Berengère; Meugnier, Emmanuelle; Castelli, Martina Galatea; Chanon, Stéphanie; Vieille-Marchiset, Aurélie & Durand, Christine [Show all 15 contributors for this article] (2017). Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice. Nature Medicine. ISSN 1078-8956. 23(8), p. 990–996. doi: 10.1038/nm.4363.
• Geng, Dawei; Jogsten, Ingrid Ericson; Dunstan, Jody; Hagberg, Jessika; Wang, Thanh & Ruzzin, Jérôme [Show all 8 contributors for this article] (2016). Gas chromatography/atmospheric pressure chemical ionization/mass spectrometry for the analysis of organochlorine pesticides and polychlorinated biphenyls in human serum. Journal of Chromatography A. ISSN 0021-9673. 1453, p. 88–98. doi: 10.1016/j.chroma.2016.05.030.
• Gauthier, Marie-Soleil; Rabasa-Lhoret, Rémi Rabasa; Prud'homme, Denis; Karelis, Antony D.; Geng, Dawei & van Bavel, Bert [Show all 7 contributors for this article] (2014). The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 99(6), p. E1061–E1066. doi: 10.1210/jc.2013-3935.
• Ibrahim, Mohammad Madani; Fjære, Even; Lock, Erik-Jan; Frøyland, Livar; Jessen, Niels & Lund, Sten [Show all 8 contributors for this article] (2012). Metabolic impacts of high dietary exposure to persistent organic pollutants in mice. Toxicology Letters. ISSN 0378-4274. 215(1), p. 8–15. doi: 10.1016/j.toxlet.2012.09.022.
• Ruzzin, Jérôme; Lee, Duk-Hee; Carpenter, David O. & Jacobs, David (2012). Reconsidering metabolic diseases: The impacts of persistent organic pollutants. Atherosclerosis. ISSN 0021-9150. 224(1), p. 1–3. doi: 10.1016/j.atherosclerosis.2012.02.039.
• Ruzzin, Jérôme (2012). Public health concern behind the exposure to persistent organic pollutants and the risk of metabolic diseases. BMC Public Health. ISSN 1471-2458. 12. doi: 10.1186/1471-2458-12-298.
• Ibrahim, Mohammad Madani; Fjære, Even; Lock, Erik-Jan; Naville, Danielle; Amlund, Heidi & Meugnier, Emmanuelle [Show all 13 contributors for this article] (2011). Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice. PLOS ONE. ISSN 1932-6203. 6(9). doi: 10.1371/journal.pone.0025170.
• Pilon, Geneviève; Ruzzin, Jérôme; Rioux, Laurie Eve; Lavigne, Charles; White, Philip J. & Frøyland, Livar [Show all 10 contributors for this article] (2011). Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat-fed rats. Metabolism: Clinical and Experimental. ISSN 0026-0495. 60(8), p. 1122–1130. doi: 10.1016/j.metabol.2010.12.005.
• Ruzzin, Jérôme; Petersen, Rasmus; Meugnier, Emmanuelle; Madsen, Lise; LOCK, ERIK-JAN & Lillefosse, Haldis Haukås [Show all 19 contributors for this article] (2010). Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome. Environmental Health Perspectives. ISSN 0091-6765. 118(4), p. 465–471. doi: 10.1289/ehp.0901321.

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• Heindel, Jerrold J.; Vom Saal, Frederick S.; Blumberg, Bruce; Bovolin, Patrizia; Calamandrei, Gemma & Ceresini, Graziano [Show all 31 contributors for this article] (2017). Correction to: Parma consensus statement on metabolic disruptors (Environmental Health: A Global Access Science Source (2015) 14:1 (54) DOI: 10.1186/s12940-015-0042-7). Environmental health. ISSN 1476-069X. 16(1). doi: 10.1186/s12940-017-0343-0.
• Bolann, Bjørn Johan; Huber, Sandra; Ruzzin, Jérôme; Brox, Jan; Huitfeldt, Henrik & Monsen, Anne Lise Bjørke (2017). Miljøgifter i kosten handler om mer enn fisk. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(14-15), p. 973–974. doi: 10.4045/tidsskr.17.0521.
• Bolann, Bjørn Johan; Huber, Sandra; Ruzzin, Jérôme; Brox, Jan; Huitfeldt, Henrik & Monsen, Anne Lise Bjørke (2017). Er miljøgifter i norsk kosthold skadelig for barn? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(4), p. 295–297. doi: 10.4045/tidsskr.16.0978.
• Ruzzin, Jérôme; Bethune, Claudette; Goksøyr, Anders; Hylland, Ketil; Lee, Duk Hee & Jacobs, David R [Show all 7 contributors for this article] (2015). Comment on "Contaminant levels in Norwegian farmed Atlantic salmon (Salmo salar) in the 13-year period from 1999 to 2011" by Nøstbakken et al. Environment International. ISSN 0160-4120. 80, p. 98–99. doi: 10.1016/j.envint.2015.01.003.
• Heindel, Jerold J.; Vom Saal, Frederick S.; Blumberg, Bruce; Bovolin, Patrizia; Calamandrei, Gemma & Ceresini, Graziano [Show all 31 contributors for this article] (2015). Parma consensus statement on metabolic disruptors. Environmental health. ISSN 1476-069X. 14:19. doi: 10.1186/s12940-015-0042-7.
• Jacobs, David R. Jr.; Ruzzin, Jérôme & Lee, Duk Hee (2014). Environmental pollutants: Downgrading the fish food stock affects chronic disease risk. Journal of Internal Medicine. ISSN 0954-6820. 276(3), p. 240–242. doi: 10.1111/joim.12205.
• Ruzzin, Jérôme & Jacobs, David (2012). The secret story of fish: decreasing nutritional value due to pollution? British Journal of Nutrition. ISSN 0007-1145. 108(3), p. 397–399. doi: 10.1017/S0007114512002048.

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