Kathrine Jørgensen Vinknes

• Olsen, Thomas; Elshorbagy, Amany; Stolt, Emma Theresia Kjelland; Åsberg, Anders; Zare, Hasse Khiabani & Bastani, Nasser Ezzatkhah [Show all 9 contributors for this article] (2024). Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study. Amino Acids. ISSN 0939-4451. 56. doi: 10.1007/s00726-024-03398-2.
• Olsen, Thomas; Vinknes, Kathrine Jørgensen; Barvíková, Kristýna; Stolt, Emma Theresia Kjelland; Lee-Ødegård, Sindre & Troensegaard, Hannibal [Show all 18 contributors for this article] (2024). Dietary sulfur amino acid restriction in humans with overweight and obesity: Evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass and adipose tissue gene expression. Redox Biology. ISSN 2213-2317. 73. doi: 10.1016/j.redox.2024.103192.
• Olsen, Thomas; Stolt, Emma Theresia Kjelland; Øvrebø, Bente; Elshorbagy, Amany; Tore, Elena C. & Lee-Ødegård, Sindre [Show all 20 contributors for this article] (2024). Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial. Journal of Translational Medicine. ISSN 1479-5876. 22(1). doi: 10.1186/s12967-023-04833-w.
• Vinknes, Kathrine Jørgensen; Olsen, Thomas; Zare, Hasse Khiabani; Bastani, Nasser Ezzatkhah; Stolt, Emma Theresia Kjelland & Dahl, Anja Falkenhaug [Show all 11 contributors for this article] (2023). Cysteine-lowering treatment with mesna against obesity: Proof of concept and results from a human phase I, dose-finding study. Diabetes, obesity and metabolism. ISSN 1462-8902. 25(11), p. 3161–3170. doi: 10.1111/dom.15210. Full text in Research Archive
• Tore, Elena C.; Eussen, Simone; Bastani, Nasser Ezzatkhah; Dagnelie, Pieter; Elshorbagy, Amany K & Grootswagers, Pol [Show all 14 contributors for this article] (2023). The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study. Journal of Nutrition. ISSN 0022-3166. 153(7), p. 2027–2040. doi: 10.1016/j.tjnut.2023.05.008.
• Elshorbagy, Amany; Bastani, Nasser Ezzatkhah; Lee-Ødegård, Sindre; Øvrebø, Bente; Haj Yasein, Nadia & Svendsen, Karianne [Show all 10 contributors for this article] (2022). The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression. Amino Acids. ISSN 0939-4451. doi: 10.1007/s00726-022-03229-2. Full text in Research Archive
• Nichenametla, Sailendra N.; Mattocks, Dwight A.L.; Cooke, Diana; Midya, Vishal; Malloy, Virginia L. & Mansilla, Wilfredo [Show all 18 contributors for this article] (2022). Cysteine restriction-specific effects of sulfur amino acid restriction on lipid metabolism. Aging Cell. ISSN 1474-9718. 21(12). doi: 10.1111/acel.13739. Full text in Research Archive
• Tore, Elena C.; Elshorbagy, Amany K.; Bakers, Frans CH; Brouwers, Marin C.G.J.; Dagnelie, Pieter & Eussen, Simone J. [Show all 17 contributors for this article] (2022). Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-022-03041-4. Full text in Research Archive
• Parys, Anthea van; Sæle, Jostein; Puaschitz, Nathalie Genevieve; Anfinsen, Åslaug Matre; Karlsson, Therese & Olsen, Thomas [Show all 12 contributors for this article] (2022). The association between dairy intake and risk of cardiovascular disease and mortality in patients with stable angina pectoris. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. 30(3), p. 219–229. doi: 10.1093/eurjpc/zwac217. Full text in Research Archive
• Svendsen, Karianne; Olsen, Thomas; Vinknes, Kathrine Jørgensen; Mundal, Liv; Holven, Kirsten Bjørklund & Bogsrud, Martin Prøven [Show all 9 contributors for this article] (2022). Risk of stroke in genetically verified familial hypercholesterolemia: A prospective matched cohort study. Atherosclerosis. ISSN 0021-9150. 358, p. 34–40. doi: 10.1016/j.atherosclerosis.2022.08.015. Full text in Research Archive Show summary

  Background and aims: Individuals with familial hypercholesterolemia (FH), causing severely elevated LDL-C, are expected to have a higher risk of ischemic stroke. The risk of hemorrhagic stroke and impact of statin use are, however, not known. We aimed to investigate the risk of incident total, ischemic and hemorrhagic stroke in individuals with FH compared to controls, and to explore the association between cumulative statin use and risk of total stroke in FH. Methods: This prospective cohort study consists of 4186 individuals with genetically verified FH and 82 180 age and sex matched controls followed from 2008 to 2018 for incident stroke. Daily defined doses (DDD) described cumulative statin exposure: 0–5000 DDD (“low”), 5000–10,000 DDD (“intermediate”), and >10 000 DDD (“high”). Results were presented as hazard ratio (95% CI) derived from Cox proportional hazards models. Results: Individuals with FH did not have a higher risk of total stroke (1.16 (0.95–1.43) nor ischemic stroke (1.11 (0.88–1.38). Excess risk of hemorrhagic stroke was observed (1.63 (1.07, 2.48) but attenuated after adjusting for antithrombotic medication (1.25 (0.81, 1.93). Among individuals with FH, there was no association between statin use and total stroke for intermediate vs. low DDD [0.69 (0.32, 1.48)] or for high vs. low DDD [0.83 (0.41, 1.67)]. Conclusions: No significant excess risk of incident total and ischemic stroke in FH, and no difference in total stroke risk among the FH population with low, intermediate, and high statin exposure were observed. The observed relationship between FH and hemorrhagic stroke was no longer significant after adjusting for use of anti- thrombotic medication.

• Parys, Anthea van; Brække, Maria Sandvik; Karlsson, Therese; Vinknes, Kathrine Jørgensen; Tell, Grethe S. & Haugsgjerd, Teresa Risan [Show all 11 contributors for this article] (2021). Assessment of dietary choline intake, contributing food items and associations with one-carbon and lipid metabolites in middle-aged and elderly adults: the Hordaland Health Study . Journal of Nutrition. ISSN 0022-3166. p. 1–12. doi: 10.1093/jn/nxab367. Full text in Research Archive
• van Parys, Anthea; Karlsson, Therese; Vinknes, Kathrine; Olsen, Thomas; Øyen, Jannike & Dierkes, Jutta [Show all 8 contributors for this article] (2021). Food Sources Contributing to Intake of Choline and Individual Choline Forms in a Norwegian Cohort of Patients With Stable Angina Pectoris. Frontiers in Nutrition. ISSN 2296-861X. 8, p. 1–8. doi: 10.3389/fnut.2021.676026. Full text in Research Archive
• Stolt, Emma Theresia Kjelland; Olsen, Thomas; Elshorbagy, Amany; Kozich, Viktor; Van Greevenbroek, Marleen M.J. & Øvrebø, Bente [Show all 10 contributors for this article] (2021). Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements. Journal of Translational Medicine. ISSN 1479-5876. 19. doi: 10.1186/s12967-021-02824-3. Full text in Research Archive
• Vinknes, Kathrine; Refsum, Helga; Turner, Cheryl; Khaw, Kay-Tee; Wareham, Nicholas J. & Forouhi, Nita G. [Show all 7 contributors for this article] (2021). Plasma Sulfur Amino Acids and Risk of Cerebrovascular Diseases: A Nested Case-Control Study in the EPIC-Norfolk Cohort. Stroke. ISSN 0039-2499. 52(1), p. 172–180. doi: 10.1161/STROKEAHA.120.029177.
• Olsen, Thomas; Øvrebø, Bente; Turner, Cheryl; Bastani, Nasser Ezzatkhah; Refsum, Helga & Vinknes, Kathrine (2021). Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study. BMC Research Notes. ISSN 1756-0500. 14(43). doi: 10.1186/s13104-021-05463-5. Full text in Research Archive
• Olsen, Thomas; Sollie, Ove; Nurk, Eha; Turner, Cheryl; Jernerén, Fredrik & Ivy, John L. [Show all 10 contributors for this article] (2020). Exhaustive Exercise and Post-exercise Protein Plus Carbohydrate Supplementation Affect Plasma and Urine Concentrations of Sulfur Amino Acids, the Ratio of Methionine to Homocysteine and Glutathione in Elite Male Cyclists. Frontiers in Physiology. ISSN 1664-042X. doi: 10.3389/fphys.2020.609335. Full text in Research Archive Show summary

  Plasma and tissue sulfur amino acid (SAA) availability are crucial for intracellular methylation reactions and cellular antioxidant defense, which are important processes during exercise and in recovery. In this randomized, controlled crossover trial among eight elite male cyclists, we explored the effect of exhaustive exercise and post-exercise supplementation with carbohydrates and protein (CHO+PROT) vs. carbohydrates (CHO) on plasma and urine SAAs, a potential new marker of methylation capacity (methionine/total homocysteine ratio [Met/tHcy]) and related metabolites. The purpose of the study was to further explore the role of SAAs in exercise and recovery. Athletes cycled to exhaustion and consumed supplements immediately after and in 30 min intervals for 120 min post-exercise. After ~18 h recovery, performance was tested in a time trial in which the CHO+PROT group cycled 8.5% faster compared to the CHO group (41:53 ± 1:51 vs. 45:26 ± 1:32 min, p

• Haugsgjerd, Teresa Risan; Egeland, Grace M.; Nygård, Ottar; Igland, Jannicke; Sulo, Gerhard & Lysne, Vegard [Show all 9 contributors for this article] (2020). Intake of carbohydrates and SFA and risk of CHD in middle-age adults: The Hordaland Health Study (HUSK). Public Health Nutrition (PHN). ISSN 1368-9800. p. 1–15. doi: 10.1017/S1368980020003043. Full text in Research Archive
• Haugsgjerd, Teresa Risan; Egeland, Grace M.; Nygård, Ottar; Vinknes, Kathrine; Sulo, Gerhard & Lysne, Vegard [Show all 8 contributors for this article] (2020). Association of dietary vitamin K and risk of coronary heart disease in middle-age adults: the Hordaland Health Study Cohort. BMJ Open. ISSN 2044-6055. 10(5). doi: 10.1136/bmjopen-2019-035953. Full text in Research Archive
• Olsen, Thomas; Turner, Cheryl; Øvrebø, Bente; Bastani, Nasser Ezzatkhah; Refsum, Helga & Vinknes, Kathrine (2020). Postprandial effects of a meal low in sulfur amino acids and high in polyunsaturated fatty acids compared to a meal high in sulfur amino acids and saturated fatty acids on stearoyl CoA-desaturase indices and plasma sulfur amino acids: a pilot study. BMC Research Notes. ISSN 1756-0500. 13. doi: 10.1186/s13104-020-05222-y. Full text in Research Archive
• Olsen, Thomas; Øvrebø, Bente; Haj Yasein, Nadia; Lee-Ødegård, Sindre; Svendsen, Karianne & Hjorth, Marit [Show all 11 contributors for this article] (2020). Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study. Journal of Translational Medicine. ISSN 1479-5876. 18(122). doi: 10.1186/s12967-020-02288-x. Full text in Research Archive
• Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind & Dhar, Indu [Show all 12 contributors for this article] (2019). Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-019-02086-2. Full text in Research Archive
• Hanvold, Susanna; Vinknes, Kathrine; Løken, Elin Bjørge; Hjartåker, Anette; Klungsøyr, Ole & Birkeland, Eline [Show all 10 contributors for this article] (2019). Does Lifestyle Intervention After Gastric Bypass Surgery Prevent Weight Regain? A Randomized Clinical Trial. Obesity Surgery. ISSN 0960-8923. 29(11), p. 3419–3431. doi: 10.1007/s11695-019-04109-7. Full text in Research Archive
• Lee-Ødegård, Sindre; Olsen, Thomas; Vinknes, Kathrine; Refsum, Helga; Gulseth, Hanne Løvdal & Birkeland, Kåre I. [Show all 7 contributors for this article] (2019). Plasma Sulphur-Containing Amino Acids, Physical Exercise and Insulin Sensitivity in Overweight Dysglycemic and Normal Weight Normoglycemic Men. Nutrients. ISSN 2072-6643. 11(1). doi: 10.3390/nu11010010. Full text in Research Archive
• Olsen, Thomas; Øvrebø, Bente; Turner, Cheryl; Bastani, Nasser Ezzatkhah; Refsum, Helga & Vinknes, Kathrine (2018). Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial. Nutrients. ISSN 2072-6643. 10(12), p. 1–15. doi: 10.3390/nu10121822. Full text in Research Archive
• Puaschitz, Nathalie Genevieve; Assmus, Jörg; Strand, Elin; Karlsson, Therese; Vinknes, Kathrine & Lysne, Vegard [Show all 10 contributors for this article] (2018). Adherence to the Healthy Nordic Food Index and the incidence of acute myocardial infarction and mortality among patients with stable angina pectoris. Journal of human nutrition and dietetics. ISSN 0952-3871. 32, p. 86–97. doi: 10.1111/jhn.12592. Full text in Research Archive
• Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Dhar, Indu & Tell, Grethe S. [Show all 11 contributors for this article] (2018). The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. 25(15), p. 1612–1620. doi: 10.1177/2047487318788587. Full text in Research Archive
• Vinknes, Kathrine; Nurk, Eha; Tell, Grethe S.; Sulo, Gerhard; Refsum, Helga & Elshorbagy, Amany K. (2017). The relation of CUN-BAE index and BMI with body fat, cardiovascular events and diabetes during a 6-year follow-up: The hordaland health study. Clinical Epidemiology. ISSN 1179-1349. 9, p. 555–566. doi: 10.2147/CLEP.S145130.
• Hanvold, Susanna; Vinknes, Kathrine; Bastani, Nasser Ezzatkhah; Turner, Cheryl; Løken, Elin Bjørge & Mala, Tom [Show all 8 contributors for this article] (2017). Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain? European Journal of Nutrition. ISSN 1436-6207. p. 1–9. doi: 10.1007/s00394-017-1533-9.
• Øyen, Jannike; Gjesdal, Clara Gram; Karlsson, Therese; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S. & Strand, Elin [Show all 11 contributors for this article] (2017). Dietary choline intake is directly associated with bone mineral density in the Hordaland Health Study. Journal of Nutrition. ISSN 0022-3166. 147(4), p. 572–578. doi: 10.3945/jn.116.243006.
• Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Tell, Grethe S. & Blomhoff, Rune [Show all 11 contributors for this article] (2017). Cardiovascular disease risk associated with serum apolipoprotein B is modified by serum vitamin A. Atherosclerosis. ISSN 0021-9150. p. 325–330. doi: 10.1016/j.atherosclerosis.2017.07.020.
• Haugsgjerd, Teresa Risan; Dierkes, Jutta; Vollset, Stein Emil; Vinknes, Kathrine; Nygård, Ottar & Seifert, Reinhard [Show all 8 contributors for this article] (2016). Association between weight change and mortality in community living older people followed for up to 14 years. The Hordaland Health Study (HUSK). The Journal of Nutrition, Health & Aging. ISSN 1279-7707. 21(8), p. 909–917. doi: 10.1007/s12603-016-0866-z.
• Mansoor, Nadia; Vinknes, Kathrine; Veierød, Marit Bragelien & Retterstøl, Kjetil (2015). Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors a meta-analysis of randomised controlled trials. British Journal of Nutrition. ISSN 0007-1145. 115(3), p. 466–479. doi: 10.1017/S0007114515004699.
• Vinknes, Kathrine; Elshorbagy, Amany K; Nurk, Eha; Drevon, Christian A; Gjesdal, Clara Gram & Tell, Grethe S [Show all 9 contributors for this article] (2013). Plasma stearoyl-CoA desaturase indices: Association with lifestyle, diet and body composition. Obesity. ISSN 1930-7381. 21(3), p. E294–E302. doi: 10.1002/oby.20011.
• Vinknes, Kathrine; Elshorbagy, Amany K.; Drevon, Christian A; Nurk, Eha; Tell, Grethe S & Nygård, Ottar [Show all 8 contributors for this article] (2013). Associations between plasma polyunsaturated fatty acids, plasma stearoyl-CoA desaturase indices and body fat. Obesity. ISSN 1930-7381. 21(9), p. E512–E519. doi: 10.1002/oby.20457.
• Vinknes, Kathrine; Dekker, Jacqueline M.; Drevon, Christian A; Refsum, Helga; Nurk, Eha & Nijpels, Giel [Show all 13 contributors for this article] (2013). Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations. Prostaglandins Leukot Essent Fatty Acids 2. Prostaglandins, Leukotrienes and Essential Fatty Acids. ISSN 0952-3278. 89(5), p. 297–303. doi: 10.1016/j.plefa.2013.09.007.
• Vinknes, Kathrine; Elshorbagy, Amany K.; Drevon, Christian A; Gjesdal, Clara Gram; Tell, Grethe S & Nygård, Ottar [Show all 8 contributors for this article] (2013). Evaluation of the body adiposity index in a caucasian population: the Hordaland Health Study. American Journal of Epidemiology. ISSN 0002-9262. 177(6), p. 586–592. doi: 10.1093/aje/kws271.
• Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal & Holen, Torgeir [Show all 12 contributors for this article] (2012). Molecular nutrition research - the modern way of performing nutritional science. Nutrients. ISSN 2072-6643. 4(12), p. 1898–1944. doi: 10.3390/nu4121898. Show summary

  In spite of amazing progress in food supply and nutritional science, and a striking increase in life expectancy of approximately 2.5 months per year in many countries during the previous 150 years, modern nutritional research has a great potential of still contributing to improved health for future generations, granted that the revolutions in molecular and systems technologies are applied to nutritional questions. Descriptive and mechanistic studies using state of the art epidemiology, food intake registration, genomics with single nucleotide polymorphisms (SNPs) and epigenomics, transcriptomics, proteomics, metabolomics, advanced biostatistics, imaging, calorimetry, cell biology, challenge tests (meals, exercise, etc.), and integration of all data by systems biology, will provide insight on a much higher level than today in a field we may name molecular nutrition research. To take advantage of all the new technologies scientists should develop international collaboration and gather data in large open access databases like the suggested Nutritional Phenotype database (dbNP). This collaboration will promote standardization of procedures (SOP), and provide a possibility to use collected data in future research projects. The ultimate goals of future nutritional research are to understand the detailed mechanisms of action for how nutrients/foods interact with the body and thereby enhance health and treat diet-related diseases.

• Vinknes, Kathrine; De Vogel, Stefan; Elshorbagy, Amany K; Nurk, Eha; Drevon, Christian A & Gjesdal, Clara Gram [Show all 9 contributors for this article] (2011). Dietary intake of protein is positively associated with percent body fat in middle-aged and older adults. Journal of Nutrition. ISSN 0022-3166. 141(3), p. 440–446. doi: 10.3945/jn.110.133710.

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• Elshorbagy, Amany; Bastani, Nasser Ezzatkhah; Lee-Ødegård, Sindre; Øvrebø, Bente; Haj Yasein, Nadia & Svendsen, Karianne [Show all 10 contributors for this article] (2023). Correction to: The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression (Amino Acids, (2022), 10.1007/s00726-022-03229-2). Amino Acids. ISSN 0939-4451. 55, p. 547–548. doi: 10.1007/s00726-023-03244-x.
• Bastani, Nasser Ezzatkhah; Refsum, Helga; Olsen, Thomas; Vinknes, Kathrine Jørgensen; Retterstøl, Kjetil & Zare, Hasse Khiabani (2022). Determination of plasma thiols using LC-MS/MS: Cysteine-lowering treatment with mesna against obesity: Preliminary results from a phase I dose-finding stud.
• Svendsen, Karianne; Olsen, Thomas; Vinknes, Kathrine Jørgensen; Mundal, Liv; Holven, Kirsten Bjørklund & Bogsrud, Martin Prøven [Show all 9 contributors for this article] (2022). No increased risk of stroke in genetically verified familial hypercholesterolemia: a prospective matched cohort study.
• Svendsen, Karianne; Vinknes, Kathrine Jørgensen; Retterstøl, Kjetil & Olsen, Thomas (2022). Why we can probably trust public policy dietary guidelines for prevention. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. 29(6), p. e209–e210. doi: 10.1093/eurjpc/zwaa008.
• Svendsen, Karianne; Vinknes, Kathrine; Retterstøl, Kjetil & Olsen, Thomas (2020). Why we can probably trust public policy dietary guidelines for prevention. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. doi: 10.1093/eurjpc/zwaa008.
• Svendsen, Karianne; Vinknes, Kathrine; Retterstøl, Kjetil & Olsen, Thomas (2020). Why we can probably trust public policy dietary guidelines for prevention. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. doi: 10.1093/EURJPC/ZWAA008.
• Øvrebø, Bente; Olsen, Thomas & Vinknes, Kathrine (2017). Stearoyl-CoA desaturase og energimetabolisme – et prosjekt ved Universitetet i Oslo. Norsk tidsskrift for ernæring (NTFE). ISSN 1503-5034. p. 20–22.
• Haugsgjerd, Teresa Risan; Dierkes, Jutta; Vollset, Stein Emil; Vinknes, Kathrine; Nygård, Ottar & Seifert, Reinhard [Show all 8 contributors for this article] (2016). Association between weight change and mortality in community living older people followed for up to 14 years: the Hordaland Health Study (HUSK).
• Mansoor, Nadia; Vinknes, Kathrine; Veierød, Marit Bragelien & Retterstøl, Kjetil (2016). Low-carbohydrate diets increase LDL-cholesterol, and thereby indicate increased risk of CVD. British Journal of Nutrition. ISSN 0007-1145. 115(12), p. 2264–2266. doi: 10.1017/S0007114516001343.

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