Marivi Nabong Moen

• Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar & Kirpekar, Finn [Show all 10 contributors for this article] (2021). Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.762032. Full text in Research Archive
• Alexeeva, Marina; Moen, Marivi Nabong; Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Xu, Xiang Ming & Muruzábal-Lecumberri, Izaskun [Show all 12 contributors for this article] (2018). Excision of uracil from DNA by hSMUG1 includes strand incision and processing. Nucleic Acids Research (NAR). ISSN 0305-1048. 47(2), p. 779–793. doi: 10.1093/nar/gky1184. Full text in Research Archive
• Moen, Marivi Nabong; Fjær, Roar; Hamdani, El Hassan; Lærdahl, Jon Kristen; Menchini, Robin Johansen & Vigeland, Magnus Dehli [Show all 12 contributors for this article] (2016). Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport. Brain. ISSN 0006-8950. 139, p. 3109–3120. doi: 10.1093/brain/aww244.
• Ougland, Rune; Jonson, Ida; Moen, Marivi Nabong; Nesse, Gaute; Asker, Gry & Klungland, Arne [Show all 7 contributors for this article] (2016). Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells. Cellular Physiology and Biochemistry. ISSN 1015-8987. 38(1), p. 173–184. doi: 10.1159/000438619.
• Ougland, Rune; Lando, David; Jonson, Ida; Dahl, John Arne; Moen, Marivi & Nordstrand, Line Mari [Show all 11 contributors for this article] (2012). ALKBH1 Is a Histone H2A Dioxygenase Involved in Neural Differentiation. Stem Cells. ISSN 1066-5099. 30(12), p. 2672–2682. doi: 10.1002/stem.1228. Full text in Research Archive
• Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne & Grini, Paul Eivind [Show all 7 contributors for this article] (2012). The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research (NAR). ISSN 0305-1048. 40(14), p. 6620–6631. doi: 10.1093/nar/gks327. Full text in Research Archive
• Moen, Marivi; Knævelsrud, Ingeborg; Haugland, Gyri Teien; Grøsvik, Kristin; Birkeland, Nils-Kåre & Klungland, Arne [Show all 7 contributors for this article] (2011). Uracil-DNA Glycosylase of Thermoplasma acidophilum Directs Long-Patch Base Excision Repair, Which Is Promoted by Deoxynucleoside Triphosphates and ATP/ADP, into Short-Patch Repair. Journal of Bacteriology. ISSN 0021-9193. 193(17), p. 4495–4508. doi: 10.1128/JB.00233-11.
• Knævelsrud, Ingeborg; Moen, Marivi; Grøsvik, Kristin; Haugland, Gyri Teien; Birkeland, Nils-Kåre & Klungland, Arne [Show all 8 contributors for this article] (2010). The Hyperthermophilic Euryarchaeon Archaeoglobus fulgidus Repairs Uracil by Single-Nucleotide Replacement. Journal of Bacteriology. ISSN 0021-9193. 192(21), p. 5755–5766. doi: 10.1128/JB.00135-10. Show summary

  Hydrolytic deamination of cytosine to uracil in cellular DNA is a major source of C-to-T transition mutations if uracil is not repaired by the DNA base excision repair (BER) pathway. Since deamination increases rapidly with temperature, hyperthermophiles, in particular, are expected to succumb to such damage. There has been only one report of crenarchaeotic BER showing strong similarities to that in most eukaryotes and bacteria for hyperthermophilic Archaea. Here we report a different type of BER performed by extract prepared from cells of the euryarchaeon Archaeoglobus fulgidus. Although immunodepletion showed that the monofunctional family 4 type of uracil-DNA glycosylase (UDG) is the principal and probably only UDG in this organism, a beta-elimination mechanism rather than a hydrolytic mechanism is employed for incision of the abasic site following uracil removal. The resulting 3' remnant is removed by efficient 3'-phosphodiesterase activity followed by single-nucleotide insertion and ligation. The finding that repair product formation is stimulated similarly by ATP and ADP in vitro raises the question of whether ADP is more important in vivo because of its higher heat stability.

• Van den Born, Erwin; Bekkelund, Anders; Moen, Marivi; Omelchenko, M.V.; Klungland, Arne & Falnes, Pål (2009). Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria. Nucleic Acids Research (NAR). ISSN 0305-1048. 37(21). doi: 10.1093/nar/gkp774.
• Ringvoll, Jeanette; Moen, Marivi N.; Nordstrand, Line M.; Meira, Lisiane B.; Pang, Bo & Bekkelund, Anders [Show all 11 contributors for this article] (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research. ISSN 0008-5472. 68(11), p. 4142–4149. Show summary

  Endogenous formation of the mutagenic DNA adduct 1,N-6-ethenoadenine (epsilon A) originates from lipid peroxidation. Elevated levels of epsilon A in cancer-prone tissues suggest a role for this adduct in the development of some cancers. The base excision repair pathway has been considered the principal repair system for epsilon A lesions until recently, when it was shown that the Escherichia coli AlkB dioxygenase could directly reverse the damage. We report here kinetic analysis of the recombinant human AlkB homologue 2 (hABH2), which is able to repair epsilon A lesions in DNA. Furthermore, cation exchange chromatography of nuclear extracts from wild-type and mABH2(-/-) mice indicates that mABH2 is the principal dioxygenase for EA repair in vivo. This is further substantiated by experiments showing that hABH2, but not hABH3, is able to complement the E. coli alkB mutant with respect to its defective repair of etheno adducts. We conclude that ABH2 is active in the direct reversal of epsilon A lesions, and that ABH2, together with the alkyl-N-adenine-DNA glycosylase, which is the most effective enzyme for the repair of epsilon A, comprise the cellular defense against epsilon A lesions.

• Wærsted, Jeanette Ringvoll; Nabong, Marivi; Nordstrand, Line Mari; Meira, LB; Pang, B & Bekkelund, Anders [Show all 11 contributors for this article] (2008). AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research. ISSN 0008-5472. 68(11), p. 4142–4149. doi: 10.1158/0008-5472.CAN-08-0796. Show summary

  Endogenous formation of the mutagenic DNA adduct 1,N6-ethenoadenine ({varepsilon}A) originates from lipid peroxidation. Elevated levels of {varepsilon}A in cancer-prone tissues suggest a role for this adduct in the development of some cancers. The base excision repair pathway has been considered the principal repair system for {varepsilon}A lesions until recently, when it was shown that the Escherichia coli AlkB dioxygenase could directly reverse the damage. We report here kinetic analysis of the recombinant human AlkB homologue 2 (hABH2), which is able to repair {varepsilon}A lesions in DNA. Furthermore, cation exchange chromatography of nuclear extracts from wild-type and mABH2–/– mice indicates that mABH2 is the principal dioxygenase for {varepsilon}A repair in vivo. This is further substantiated by experiments showing that hABH2, but not hABH3, is able to complement the E. coli alkB mutant with respect to its defective repair of etheno adducts. We conclude that ABH2 is active in the direct reversal of {varepsilon}A lesions, and that ABH2, together with the alkyl-N-adenine-DNA glycosylase, which is the most effective enzyme for the repair of {varepsilon}A, comprise the cellular defense against {varepsilon}A lesions. [Cancer Res 2008;68(11):4142–9]

• Leiros, Ingar; Nabong, MP; Nabong, Marivi; Grosvik, K; Grøsvik, Kristin & Ringvoll, J [Show all 20 contributors for this article] (2007). Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal. ISSN 0261-4189. 26. doi: 10.1038/sj.emboj.7601662.

View all works in Cristin

• Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn & Klungland, Arne [Show all 7 contributors for this article] (2017). hSMUG1 is a bi-functional DNA glycosylase.
• Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn & Klungland, Arne [Show all 7 contributors for this article] (2016). hSMUG1-catalysed uracil-DNA strand incision.
• Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn & Klungland, Arne [Show all 7 contributors for this article] (2016). hSMUG1-catalysed uracil-DNA strand incision.
• Meza, Trine Johansen; Moen, Marivi N.; Vågbø, Cathrine B.; Ulleland, Marius; Krokan, Hans Einar & Arne, Klungland [Show all 8 contributors for this article] (2010). The DNA dioxygenase AtALKBH2 protects Arabidopsis thaliana against methylation damage.

View all works in Cristin