Shadab Abadpour

• Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Larsen, Ulrik; Unger, Lucas; Abadpour, Shadab & Paulo, Joao A. [Show all 9 contributors for this article] (2024). The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop. Mechanisms of Ageing and Development. ISSN 0047-6374. 220. doi: 10.1016/j.mad.2024.111951.
• Aizenshtadt, Aleksandra; Wang, Chencheng; Abadpour, Shadab; Menezes, Pedro Duarte; Wilhelmsen, Ingrid & Dalmao-Fernandez, Andrea [Show all 15 contributors for this article] (2024). Pump-Less, Recirculating Organ-on-Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver. Advanced Healthcare Materials. ISSN 2192-2640. doi: 10.1002/adhm.202303785.
• Wang, Chencheng; Abadpour, Shadab; Olsen, Petter Angell; Wang, Daxin; Stokowiec, Justyna & Chera, Simona [Show all 11 contributors for this article] (2024). Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells. Transplant International. ISSN 0934-0874. 37. doi: 10.3389/ti.2024.11900.
• Mathisen, Andreas Frøslev; Abadpour, Shadab; Legøy, Thomas Aga; Paulo, Joao A.; Ghila, Luiza Mihaela & Scholz, Hanne [Show all 7 contributors for this article] (2023). Global proteomics reveals insulin abundance as a marker of human islet homeostasis alterations. Acta Physiologica. ISSN 1748-1708. 239(2). doi: 10.1111/apha.14037. Full text in Research Archive
• Olsen, Christine; Wang, Chencheng; Aizenshtadt, Aleksandra; Abadpour, Shadab; Lundanes, Elsa & Skottvoll, Frøydis Sved [Show all 11 contributors for this article] (2023). Simultaneous LC–MS determination of glucose regulatory peptides secreted by stem cell–derived islet organoids. Electrophoresis. ISSN 0173-0835. 44(21-22), p. 1682–1697. doi: 10.1002/elps.202300095. Full text in Research Archive
• Abadpour, Shadab; Niemi, Essi Maria; Strid Orrhult, Linnea; Hermanns, Carolin; de Vries, Rick & Parreiras Nogueira, Liebert [Show all 12 contributors for this article] (2023). Adipose-Derived Stromal Cells Preserve Pancreatic Islet Function in a Transplantable 3D Bioprinted Scaffold. Advanced Healthcare Materials. ISSN 2192-2640. 12(32). doi: 10.1002/adhm.202300640. Full text in Research Archive
• Olsen, Christine; Wiborg, Elisa; Lundanes, Elsa; Abadpour, Shadab; Scholz, Hanne & Wilson, Steven Ray Haakon (2022). On-line reduction of insulin disulfide bonds with photoinduced radical reactions, upstream to nano liquid chromatography-mass spectrometry. Separation Science Plus (SSC plus). ISSN 2573-1815. 5(6), p. 220–227. doi: 10.1002/sscp.202200022.
• Olsen, Christine; Wang, Chencheng; Abadpour, Shadab; Lundanes, Elsa; Hansen, Audun Skau & Skottvoll, Frøydis Sved [Show all 8 contributors for this article] (2022). Determination of insulin secretion from stem cell-derived islet organoids with liquid chromatography-tandem mass spectrometry. Journal of chromatography. B. ISSN 1570-0232. 1215. doi: 10.1016/j.jchromb.2022.123577. Full text in Research Archive
• Kogler, Stian; Aizenshtadt, Aleksandra; Harrison, Sean; Skottvoll, Frøydis Sved; Berg, Henriette Engen & Abadpour, Shadab [Show all 14 contributors for this article] (2022). "Organ-in-a-Column" Coupled On-line with Liquid Chromatography-Mass Spectrometry. Analytical Chemistry. ISSN 0003-2700. 94(50), p. 17677–17684. doi: 10.1021/acs.analchem.2c04530. Full text in Research Archive
• Fernandez, Manuel Carrasco; Wang, Chencheng; Søviknes, Anne Mette; Bjørlykke, Yngvild; Abadpour, Shadab & Paulo, Joao A. [Show all 16 contributors for this article] (2022). Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. Diabetes. ISSN 0012-1797. 71(4), p. 862–869. doi: 10.2337/db20-1279. Show summary

  Studies of monogenic diabetes are particularly useful because we can gain insight into the molecular events of pancreatic β-cell failure. Maturity-onset diabetes of the young 1 (MODY1) is a form of monogenic diabetes caused by a mutation in the HNF4A gene. Human-induced pluripotent stem cells (hiPSCs) provide an excellent tool for disease modeling by subsequently directing differentiation toward desired pancreatic islet cells, but cellular phenotypes in terminally differentiated cells are notoriously difficult to detect. Re-creating a spatial (three-dimensional [3D]) environment may facilitate phenotype detection. We studied MODY1 by using hiPSC-derived pancreatic β-like patient and isogenic control cell lines in two different 3D contexts. Using size-adjusted cell aggregates and alginate capsules, we show that the 3D context is critical to facilitating the detection of mutation-specific phenotypes. In 3D cell aggregates, we identified irregular cell clusters and lower levels of structural proteins by proteome analysis, whereas in 3D alginate capsules, we identified altered levels of glycolytic proteins in the glucose sensing apparatus by proteome analysis. Our study provides novel knowledge on normal and abnormal function of HNF4A, paving the way for translational studies of new drug targets that can be used in precision diabetes medicine in MODY.

• Abadpour, Shadab; Wang, Chencheng; Niemi, Essi Maria & Scholz, Hanne (2021). Tissue Engineering Strategies for Improving Beta Cell Transplantation Outcome. Current Transplantation Reports. 8(3), p. 205–219. doi: 10.1007/s40472-021-00333-2. Full text in Research Archive
• Zhou, Alex-Xianghua; Mondal, Tanmoy; Tabish, Ali Mustafa; Abadpour, Shadab; Ericson, Elke & Smith, David M. [Show all 11 contributors for this article] (2021). The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 320(4), p. E846–E857. doi: 10.1152/AJPENDO.00335.2020.
• Ghila, Luiza; Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Abadpour, Shadab; Paulo, Joao A. & Scholz, Hanne Bjørnson [Show all 8 contributors for this article] (2021). Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human ipsc-derived pancreatic progenitors. International Journal of Molecular Sciences. ISSN 1661-6596. 22(7). doi: 10.3390/ijms22073698. Full text in Research Archive
• Abadpour, Shadab; Tyrberg, Björn; Schive, Simen Walberg; Huldt, Charlotte; Gennemark, P & Ryberg, Erik [Show all 12 contributors for this article] (2020). Inhibition of the Prostaglandin D(2)-Gpr44/Dp2 Axis Improves Human Islet Survival and Function. Diabetologia. ISSN 0012-186X. 63(7), p. 1355–1367. doi: 10.1007/s00125-020-05138-z. Full text in Research Archive
• Abadpour, Shadab; Aizenshtadt, Aleksandra; Olsen, Petter Angell; Shoji, Kayoko; Wilson, Steven Ray Haakon & Krauss, Stefan [Show all 7 contributors for this article] (2020). Pancreas-on-a-Chip Technology for Transplantation Applications. Current Diabetes Reports. ISSN 1534-4827. 20. doi: 10.1007/s11892-020-01357-1. Full text in Research Archive
• Kogler, Stian; Harrison, Sean; Aizenshtadt, Aleksandra; Skottvoll, Frøydis Sved; Abadpour, Shadab & Krauss, Stefan [Show all 10 contributors for this article] (2020). “Organoid-in-a-column” coupled on-line with liquid chromatography-mass spectrometry. bioRxiv. ISSN 2692-8205. doi: 10.1101/2020.09.08.282756.
• Legøy, Thomas Aga; Vethe, Heidrun; Abadpour, Shadab; Strand, Berit Løkensgard; Scholz, Hanne & Paulo, Joao A. [Show all 9 contributors for this article] (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling . Scientific Reports. ISSN 2045-2322. 10, p. 1–16. doi: 10.1038/s41598-019-57305-x. Full text in Research Archive
• Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Salim, Zaidon; Vethe, Heidrun; Bjørlykke, Yngvild & Abadpour, Shadab [Show all 11 contributors for this article] (2020). In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 8:109, p. 1–14. doi: 10.3389/fcell.2020.00109. Full text in Research Archive
• Legøy, Thomas Aga; Ghila, Luiza; Vethe, Heidrun; Abadpour, Shadab; Mathisen, Andreas Frøslev & Paulo, Joao A. [Show all 9 contributors for this article] (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiologica. ISSN 1748-1708. 23:247577, p. 1–16. doi: 10.1111/apha.13433. Full text in Research Archive
• Vethe, Heidrun; Legøy, Thomas Aga; Abadpour, Shadab; Strand, Berit Løkensgard; Scholz, Hanne & Paulo, Joao A. [Show all 9 contributors for this article] (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. bioRxiv. ISSN 2692-8205. doi: 10.1101/791442.
• Schive, Simen Walberg; Fjukstad, Ragnhild; Josefsen, Dag; Katavic, Marina; Abadpour, Shadab & Gullestad, Hans Petter [Show all 8 contributors for this article] (2018). Automated isolation and expansion of human adipose tissuederived stem cells for a seamless translation into clinical trials. CellR4 (repair, Replacement, Regenerative&Reprogramming. ISSN 2329-7042. 6(2).
• Abadpour, Shadab; Halvorsen, Bente; Sahraoui, Afaf; Korsgren, Olle; Aukrust, Pål & Scholz, Hanne (2018). Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT. Journal of Molecular Endocrinology. ISSN 0952-5041. 60(3), p. 171–183. doi: 10.1530/JME-17-0182.
• Abadpour, Shadab; Göpel, Sven O; Schive, Simen Walberg; Korsgren, Olle; Foss, Aksel & Scholz, Hanne (2017). Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-01805-1.
• Kloster-Jensen, Kristine; Vethe, Nils Tore; Bremer, Sara; Abadpour, Shadab; Korsgren, Olle & Foss, Aksel [Show all 8 contributors for this article] (2015). Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro. Transplant International. ISSN 0934-0874. 28(10), p. 1152–1161. doi: 10.1111/tri.12617.
• Sahraoui, Afaf; Winzell, Maria Sörhede; Gorman, Tracy; Smith, Dave M.; Skrtic, Stanko & Høyem, Merete [Show all 11 contributors for this article] (2015). The effects of exendin-4 treatment on graft failure: An animal study using a novel revascularized minimal human islet transplant model. PLOS ONE. ISSN 1932-6203. 10(3). doi: 10.1371/journal.pone.0121204. Full text in Research Archive

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• Abadpour, Shadab; Niemi, Essi Maria; Strid Orrhult, Linnea; Parreiras Nogueira, Liebert; Haugen, Håvard Jostein & Josefsen, Dag [Show all 10 contributors for this article] (2021). 307.7: 3D Bioprinting of Functional Islets With Adipose-derived Stromal Cells in an Alginate/Nanocellulose Scaffold. Transplantation. ISSN 0041-1337. p. S25–S25. doi: 10.1097/01.tp.0000804424.50335.7e.
• Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Alexandra; Chera, Simona; Ghila, Luiza Mihaela & Ræder, Helge [Show all 7 contributors for this article] (2021). Glucose during in vitro pancreatic beta cells regeneration: friends or for?
• Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Alexandra; Chera, Simona; Ghila, Luiza Mihaela & Ræder, Helge [Show all 7 contributors for this article] (2021). 402.2: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells. Transplantation. ISSN 0041-1337. p. S27–S27. doi: 10.1097/01.tp.0000804436.14096.44.

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