Chromatin Biology
Chromatin structure, epigenetics, and other gene regulatory processes play an integral part in a cell's response to developmental and environmental stimuli. Many chronic diseases are characterized by epigenetic reprogramming and deregulation of gene expression.
We study
Epigenetic mechanisms during stem cell differentiation , by combining genome editing with in vitro and in vivo approaches (Eskeland ).
Chromatin structure and transcription factor regulation in cancer , by integrating ChiP, single cell ATAC, and RNA-sequencing data, visualized with custom-made, open-source programs (Eskeland ).
The effect of xenobiotic signaling on gene regulation in skeletal muscle , using cell cultures, mouse models, and human cohort samples (Ruzzin ).
Chromatin modifications and genome organization during multi-lineage stem-cell differentiation in normal and laminopathy contexts (Collas/Sæther ).
3-dimensional chromatin organization , using high-throughput chromatin interaction data, microscopy and in-house designed computational tools (Collas ).
Publications
Principal investigators
The PIs (left to right): Thomas Sæther, Jerome Ruzzin, Philippe Collas and Ragnhild Eskeland. Photo: Åsne Rambøl Hillestad, UiO
Published June 9, 2023 1:25 PM
- Last modified Jan. 19, 2024 1:42 PM