Our latest publications

Selected publications

• Hanage WP, Fraser C, Tang J, Connor T, Corander J. (2009) Hyper-recombination, diversity and antibiotic resistance in the pneumococcus. Science, 324, 1454-1457.
• John A. Lees, Minna Vehkala, Niko Välimäki, Simon R. Harris, Claire Chewapreecha, Nicholas J. Croucher, Pekka Marttinen, Mark R. Davies, Andrew C. Steer, Steven Y. C. Tong, Antti Honkela, Julian Parkhill, Stephen D. Bentley, Jukka Corander (2016) Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes. Nature Communications, doi:10.1038/ncomms12797.
• Marcin J. Skwark, Nicholas J Croucher, Santeri Puranen, Claire Chewapreecha, Maiju Pesonen, Ying Ying Xu, Paul Turner, Simon R. Harris, Stephen B. Beres, James M. Musser, Julian Parkhill, Stephen D. Bentley, Erik Aurell, Jukka Corander (2017) Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis. PloS Genetics, DOI: 10.1371/journal.pgen.1006508.
• Michael Gutmann, Jukka Corander (2016). Bayesian Optimization for Likelihood-Free Inference of Simulator-Based Statistical Models. Journal of Machine Learning Research, 17 (125), 1-47.
• Jukka Corander, Christophe Fraser, Michael U. Gutmann, Brian Arnold, William P. Hanage, Stephen D. Bentley, Marc Lipsitch, Nicholas J. Croucher (2017). Frequency-dependent selection in vaccine-associated pneumococcal population dynamics. Nature Ecology & Evolution, DOI: 10.1038/s41559-017-0337-x.
• Emily Richardson, Rodrigo Bacigalupe, Ewan Harrison, Lucy Weinert, Samantha Lycett, Manouk Vrieling, Kirsty Robb, Paul Hoskisson, Matthew Holden, Edward Feil, Gavin Paterson, Steven Tong, Adebayo Shittu, Willem van Wamel, David Aanensen, Julian Parkhill, Sharon Peacock, Jukka Corander, Mark Holmes, and Ross Fitzgerald (2018) Gene exchange drives the ecological success of a multi-host bacterial pathogen. Nature Ecology & Evolution, doi: 10.1038/s41559-018-0617-0.
• Johan Pensar, Santeri Puranen, Brian Arnold, Neil MacAlasdair, Juri Kuronen, Gerry Tonkin-Hill, Maiju Pesonen, Yingying Xu, Aleksi Sipola, Leonor Sánchez-Busó, John A Lees, Claire Chewapreecha, Stephen D Bentley, Simon R Harris, Julian Parkhill, Nicholas J Croucher, Jukka Corander (2019) Genome-wide epistasis and co-selection study using mutual information. Nucleic Acids Research, doi: 10.1093/nar/gkz656.
• Caroline Colijn, Jukka Corander, Nicholas J. Croucher (2020) Designing ecologically-optimised pneumococcal vaccines using population genomics. Nature Microbiology, DOI: 10.1038/s41564-019-0651-y.
• Rebecca A Gladstone, Alan McNally, Anna K. Pöntinen, Gerry Tonkin-Hill, John A. Lees, Kusti O. Skytén, François Cléon, Martin O. K. Christensen, Bjørg C. Haldorsen, Kristina K. Bye, Karianne W. Gammelsrud, Reidar Hjetland, Angela Kümmel, Hege E. Larsen, Paul Christoffer Lindemann, Iren H. Löhr, Åshild Marvik, Einar Nilsen, Marie T. Noer, Gunnar S. Simonsen, Martin Steinbakk, Ståle Tofteland, Marit Vattøy, Stephen D. Bentley, Nicholas J. Croucher, Julian Parkhill, Pål J. Johnsen, Ørjan Samuelsen, Jukka Corander (2021) Emergence and dissemination of antimicrobial resistance in Escherichia coli causing bloodstream infections: a nationwide longitudinal microbial population genomic study in Norway between 2002-2017. Lancet Microbe, doi: 10.1016/S2666-5247(21)00031-8.
• Anu Kantele, Esther Kuenzli, Steven J Dunn, David AB Dance, Paul N Newton, Viengmon Davong, Sointu Mero, Sari H Pakkanen, Andreas Neumayr, Christoph Hatz, Ann Snaith, Teemu Kallonen, Jukka Corander, Alan McNally (2021) Prospective study of intestinal multidrug-resistant bacteria contracted by visitors to a high-endemic setting: daily real-time sampling abroad to analyse acquisition rates and dynamics of colonisation. Lancet Microbe, doi: 10.1016/S2666-5247(20)30224-X.
• Anna K. Pöntinen, Janetta Top, Sergio Arredondo-Alonso, Gerry Tonkin-Hill, Ana R. Freitas, Carla Novais, Rebecca A. Gladstone, Maiju Pesonen, Rodrigo Meneses, Henri Pesonen, John A. Lees, Dorota Jamrozy, Stephen D. Bentley, Val Fernandez Lanza, Carmen Torres, Luisa Peixe, Teresa M. Coque, Julian Parkhill, Anita C. Schürch, Rob J. L. Willems, Jukka Corander (2021) Apparent nosocomial adaptation of the generalist major pathogen Enterococcus faecalis predates the modern hospital era. Nature Communications, doi: 10.1038/s41467-021-21749-5.
• Gerry Tonkin-Hill, Clare Ling, Chrispin Chaguza, Susannah J Salter, Pattaraporn Hinfonthong, Elissavet Nikolaou, Natalie Tate, Andrzej Pastusiak, Claudia Turner, Claire Chewapreecha, Simon DW Frost, Jukka Corander, Nicholas J Croucher, Paul Turner, Stephen D Bentley (2022) Pneumococcal within-host diversity during colonisation, transmission and treatment. Nature Microbiology, doi: 10.1038/s41564-022-01238-1.
• Jukka Corander, William P Hanage, Johan Pensar (2022). Causal discovery for the microbiome. Lancet Microbe, DOI: 10.1016/S2666-5247(22)00186-0.
• Sebastiaan J. van Hal, Rob J. L. Willems, Theodore  Gouliouris, Susan A. Ballard, Teresa M. Coque, Anette M. Hammerum, Kristin Hegstad, Mette Pinholt, Benjamin P. Howden, Surbhi Malhotra-Kumar, Guido Werner, Katsunori Yanagihara, Ashlee M. Earl, Katherine E. Raven, Jukka Corander, Rory Bowden (2022) The interplay between community and hospital Enterococcus faecium clones within healthcare settings, a genomic analysis. Lancet Microbe, doi: 10.1016/S2666-5247(21)00236-6.
• Harry A. Thorpe, Ross Booton, Teemu Kallonen, Marjorie J. Gibbon, Natacha Couto, Virginie Passet, Juan Sebastian Lopez Fernandez, Carla Rodrigues, Louise Matthews, Sonia Mitchell, Richard Reeve, Sophia David, Cristina Merla, Marta Corbella, Carolina Ferrari, Francesco Comandatore, Piero Marone, Sylvain Brisse, Davide Sassera, Jukka Corander, Edward J. Feil (2022) A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings. Nature Microbiology, doi: 10.1038/s41564-022-01263-0.
• Jessica K. Calland, Kaisa Haukka, Stephen W. Kpordze, Atanyiwoen Brusah, Marta Corbella, Cristina Merla, Ørjan Samuelsen, Edward J. Feil, Davide Sassera, Akosua B. Karikari, Courage K. S. Saba, Harry A. Thorpe, Jukka Corander (2023) Population structure and antimicrobial resistance among Klebsiella isolates sampled from human, animal, and environmental sources in Ghana: A cross-sectional genomic One Health study. Lancet Microbe, DOI: 10.1016/S2666-5247(23)00208-2.
• Tommi Mäklin,  Harry A. Thorpe,  Anna K. Pöntinen,  Rebecca A. Gladstone,  Yan Shao,  Maiju Pesonen,  Alan McNally,  Pål J. Johnsen,  Ørjan Samuelsen,  Trevor D. Lawley,  Antti Honkela,  Jukka Corander (2022) Strong pathogen competition in neonatal gut colonization. Nature Communications, doi: 10.1038/s41467-022-35178-5.
• Sergio Arredondo-Alonso, George Blundell-Hunter, Zuyi Fu, Rebecca A. Gladstone, Alfred Fillol-Salom, Jessica Loraine, Elaine Cloutman-Green, Pål J. Johnsen, Ørjan Samuelsen, Anna K. Pöntinen, François Cléon, Susana Chavez-Bueno, Miguel Ángel De la Cruz, Miguel A. Ares, Manivanh Vongsouvath,  Agnieszka Chmielarczyk, Carolyne Horner, Nigel Klein, Alan McNally, Joice Neves Reis, José R. Penadés, Nicholas R. Thomson, Jukka Corander, Peter W. Taylor, Alex J. McCarthy (2023) Evolutionary and Functional History of the Escherichia coli K1 Capsule. Nature Communications, DOI: 10.1038/s41467-023-39052-w.
• Anna K. Pöntinen, Rebecca A. Gladstone, Henri Pesonen, Maiju Pesonen, François Cléon, Benjamin J. Parcell, Teemu Kallonen, Gunnar Skov Simonsen, Nicholas J. Croucher, Alan McNally, Julian Parkhill, Pål J. Johnsen, Ørjan Samuelsen, Jukka Corander (2024) Modulation of multi-drug resistant clone success in Escherichia coli populations: a longitudinal multi-country genomic and antibiotic usage cohort study. Lancet Microbe, DOI: 10.1016/S2666-5247(23)00292-6.

• Berge, Leon Alexander Mclaren; Shala, Nita Kaupang; Barone-Adesi, Francesco; Hosgood, H Dean; Samuelsen, Sven Ove & Bråtveit, Magne [Show all 13 contributors for this article] (2024). Exposure to fibres and risk of pleural mesothelioma in the Norwegian Offshore Petroleum Workers cohort. Occupational and Environmental Medicine. ISSN 1351-0711. doi: 10.1136/oemed-2024-109424.
• Rehbinder, Eva Maria; Gerdin, Sabina Wärnberg; Hoyer, Angela; Bradley, Maria; Carlsen, Karin Cecilie Lødrup & Granum, Berit [Show all 15 contributors for this article] (2024). Frequent oil baths and skin barrier during infancy in the PreventADALL study. British Journal of Dermatology. ISSN 0007-0963. 191(1), p. 49–57. doi: 10.1093/bjd/ljae091.
• Witteveen, Sandra; Hans, Jörg B; Izdebski, Radosław; Hasman, Henrik; Samuelsen, Ørjan & Dortet, Laurent [Show all 41 contributors for this article] (2024). Dissemination of extensively drug-resistant NDM-producing Providencia stuartii in Europe linked to patients transferred from Ukraine, March 2022 to March 2023. Eurosurveillance. ISSN 1025-496X. 29(23). doi: 10.2807/1560-7917.ES.2024.29.23.2300616.
• Mallawaarachchi, Sudaraka; Tonkin-Hill, Gerry; Pöntinen, Anna Kaarina; Calland, Jessica K.; Gladstone, Rebecca Ashley & Alonso, Sergio Arredondo [Show all 13 contributors for this article] (2024). Detecting co-selection through excess linkage disequilibrium in bacterial genomes. NAR Genomics and Bioinformatics. ISSN 2631-9268. 6(2). doi: 10.1093/nargab/lqae061.
• Kjeseth, Trond; Hagen, Rolf E.; Edwin, Bjørn von Gohren; Lai, Xiaoran; Røsok, Bård Ingvald & Tholfsen, Tore [Show all 8 contributors for this article] (2024). Impact of pancreas transection site on incidence of pancreatic fistula after distal pancreatectomy: a propensity score matched study. HPB. ISSN 1365-182X. doi: 10.1016/j.hpb.2024.05.012.
• Salte, Odd Bjørn; Olbers, Torsten; Risstad, Hilde; Fagerland, Morten; Søvik, Torgeir Thorson & Høgestøl, Ingvild Kristine [Show all 9 contributors for this article] (2024). Ten-Year Outcomes Following Roux-en-Y Gastric Bypass vs Duodenal Switch for High Body Mass Index: A Randomized Clinical Trial. JAMA Network Open. ISSN 2574-3805. doi: 10.1001/jamanetworkopen.2024.14340.
• Krutto, Annika; Haugdahl Nost, Therese & Thoresen, Magne (2024). A heavy-tailed model for analyzing miRNA-seq raw read counts. Statistical Applications in Genetics and Molecular Biology. ISSN 1544-6115. 23(1). doi: 10.1515/sagmb-2023-0016.
• Tveiten, Lars; Diep, Lien My; Halvorsen, Thomas & Markestad, Trond (2024). Normal range and risk factors for deviating body temperatures during the first 24 hours in term-born infants under standardised care: an observational study. BMJ Paediatrics Open. ISSN 2399-9772. 8(1). doi: 10.1136/bmjpo-2024-002596. Show summary

  Objective Body temperature for a known ambient temperature is not known for infants born at term. We aimed to determine the normal range and the incidences of hypothermia and hyperthermia during the first 24 hours of life in healthy term-born infants nursed according to WHO recommendations. Design Prospective observational study. Setting Norwegian single centre district hospital. Infants were observed during skin-to-skin care or when dressed in cots. Participants Convenience sample of 951 healthy infants born at term. Methods Delivery room temperature was aimed at 26–30°C and rooming-in temperature at 24°C. We measured rectal and room temperatures at 2, 4, 8, 16 and 24 hours of age. Main outcome measures Percentile curves for rectal temperature. Proportions and risk factors for hypothermia and hyperthermia. Results The mean (SD) room temperature was 24.0°C (1.1), 23.8°C (1.0), 23.8°C (1.0)., 23.7°C (0.9) and 23.8°C (0.9). The median (2.5, 97.5 percentile) rectal temperature was 36.9°C (35.7–37.9), 36.8°C (35.9–37.5), 36.9°C (36.1–37.5), 37.0°C (36.4–37.7) and 37.1°C (36.5–37.7). Hypothermia (37.5°C) occurred in 12% and most commonly in large infants after 8 hours of life. Risk factors for hyperthermia were high birth weight (OR 2.2 (95% CI, 1.4 to 3.5), per kg), being awake, nursed skin to skin and being born through heavily stained amniotic fluid. Conclusions Term-born infants were at risk of hypothermia during the first hours after birth even when nursed in an assumed adequate thermal environment and at risk of hyperthermia after 8 hours of age.

• Ohnstad, Hege Oma; Blix, Egil Støre; Akslen, Lars Andreas; Gilje, Bjørnar; Raj, Sunil Xavier & Skjerven, Helle [Show all 46 contributors for this article] (2024). Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer—a prospective national multicentre study (EMIT-1). ESMO Open. ISSN 2059-7029. 9(6). doi: 10.1016/j.esmoop.2024.103475.
• Rolfsen, Mads Peder; Gammelsrud, Karianne Wiger; Espeland, Ansgar; Bråten, Lars Christian Haugli; Mjønes, Sverre Bugge & Austevoll, Ivar Magne [Show all 15 contributors for this article] (2024). Bacterial growth in patients with low back pain and Modic changes: protocol of a multicentre, case–control biopsy study. BMJ Open. ISSN 2044-6055. doi: 10.1136/bmjopen-2023-082244.
• Torland, Lilly Anne; Lai, Xiaoran; Kumar, Surendra; Riis, Margit; Geisler, Jürgen & Lüders, Torben [Show all 10 contributors for this article] (2024). Benign breast tumors may arise on different immunological backgrounds. Molecular Oncology. ISSN 1574-7891. doi: 10.1002/1878-0261.13655.
• Merkus, Suzanne; Hoff, Rune; Hasting, Rachel Louise; Undem, Karina; Robroek, Suzan J.W. & Gran, Jon Michael [Show all 7 contributors for this article] (2024). Gender and educational differences in work participation and working years lost in Norway. Scandinavian Journal of Work, Environment and Health. ISSN 0355-3140. doi: 10.5271/sjweh.4166. Full text in Research Archive Show summary

  Objectives This study aimed to quantify the duration of work participation and reasons for working years lost, according to gender and educational attainment, among a Norwegian population. Methods Register data on labor market attachment between 2000–2015 were obtained from Statistics Norway. We included five cohorts: individuals turning 20 (N=323 333), 30 (N=386 006), 40 (N=388 962), 50 (N=358 745), and 60 years (N=284 425) between 1 January 2000 and 31 December 2005. Individuals were followed for ten years. Data completeness allowed calculation of the average time spent in work and years lost to healthrelated absences and non-employment states per cohort. Changes in state probabilities over time were also depicted. Mean differences between genders and educational levels, and corresponding 95% confidence intervals were based on 1000 bootstrap samples. Results Both genders spent most time in work; however, per cohort, women worked approximately one year less than men. As cohorts aged, main reasons for working years lost changed from education and economic inactivity to sickness absence and disability pensioning; this trend was stronger for women than men. Individuals with a low education spent fewer years in work and more years in sickness absence and disability pensioning than highly educated peers. This difference tended to be larger for women and older cohorts. Conclusions Per cohort, women participated one year less in work than men and, depending on age, spent more time in education, economic inactivity, sickness absence, and disability pensioning. Stronger educational gradients were seen for work and health-related absences for older cohorts and women.

• Nordengen, Anne Lene; Krutto, Annika; Kværner, Ane Sørlie; Alavi, Dena Treider; Henriksen, Hege & Smeland, Sigbjørn [Show all 11 contributors for this article] (2024). Attenuation of DNA base oxidation in post-surgery colorectal stage III patients at subsequent follow-ups. Free Radical Biology & Medicine. ISSN 0891-5849. 221, p. 75–80. doi: 10.1016/j.freeradbiomed.2024.05.029. Show summary

  DNA damage caused by oxidative reactions plays a crucial role in the pathogenesis of colorectal cancer (CRC). In a previous cross-sectional study, CRC patients diagnosed with regional disease (stage III) exhibited a higher level of DNA base oxidation in peripheral blood mononuclear cells (PBMCs) 2-9 months post-surgery compared to those with localized disease (stage I-II). To further explore this observation over time, the present study aimed to investigate DNA base oxidation in CRC patients with localized versus regional disease 6 and 12 months after the initial measurements. The present study included patients enrolled in the randomized controlled trial Norwegian Dietary Guidelines and Colorectal Cancer Survival (CRC-NORDIET). The standard comet assay, modified with the lesion-specific enzyme formamidopyrimidine DNA glycosylase (Fpg), was applied to measure DNA base oxidation in PBMCs at the 6- and 12-month follow-ups. Of the 255 patients assessed at baseline, 156 were included at the 6-month follow-up, with 89 of these patients included in the 12-month follow-up. In contrast to our observation at baseline, there were no significant differences in the levels of DNA base oxidation between patients diagnosed with localized disease and those with regional involvement at the 6- and 12-month follow-up visits (P=0.81 and P=0.09, respectively). Patients with stage III disease exhibited a significant decrease in the levels of DNA base oxidation from baseline to 6 months (P

• Mohamad, Dima; Kjørholt, Anne Trine; Pesonen, Henri & Tateo, Luca (2024). Inclusion of Syrian students in need of special support in Norwegian schools - a qualitative study with students and parents. European Journal of Special Needs Education. ISSN 0885-6257. doi: 10.1080/08856257.2024.2354606. Full text in Research Archive
• Strand, Elin Bolle; Solberg Nes, Lise ; Børøsund, Elin; Pripp, Are Hugo; Malarkey, William & Dammen, Toril (2024). Psychometric properties of the REMAP resilience scale in a Norwegian sample of ME/CFS patients and healthy controls. . Psychological Test Adaptation and Development (PTAD). 5, p. 163–174. doi: 10.1027/2698-1866/a000076. Full text in Research Archive
• Pedersen, E.S.L.; de Jong Carmen, Jong; Jurca, M.; Berger, D.O.; Sanz, J. & Sluka, S.H.M. [Show all 12 contributors for this article] (2024). Cystic fibrosis newborn screening in Switzerland – evaluation and scenarios for improvement after 11 years of follow-up. Journal of Cystic Fibrosis. ISSN 1569-1993. doi: 10.1016/j.jcf.2024.04.008.
• Nordengen, Anne Lene; Zheng, Congying; Krutto, Annika; Kværner, Ane Sørlie; Alavi, Dena Treider & Henriksen, Hege [Show all 13 contributors for this article] (2024). Effect of a personalized intensive dietary intervention on base excision repair (BER) in colorectal cancer patients: Results from a randomized controlled trial. Free Radical Biology & Medicine. ISSN 0891-5849. 218, p. 178–189. doi: 10.1016/j.freeradbiomed.2024.04.211. Show summary

  DNA repair is essential to maintain genomic integrity and may affect colorectal cancer (CRC) patients’ risk of secondary cancers, treatment efficiency, and susceptibility to various comorbidities. Bioactive compounds identified in plant food have the potential to modulate DNA repair mechanisms, but there is limited evidence of how dietary factors may affect DNA repair activity in CRC patients in remission after surgery. The aim of this study was to investigate the effect of a 6 months personalized intensive dietary intervention on DNA repair activity in post-surgery CRC patients (stage I-III). The present study included patients from the randomized controlled trial CRC-NORDIET, enrolled 2-9 months after surgery. The intervention group received an intensive dietary intervention emphasizing a prudent diet with specific plant-based foods suggested to dampen inflammation and oxidative stress, while the control group received only standard care advice. The comet-based in vitro repair assay was applied to assess DNA repair activity, specifically base excision repair (BER), in peripheral blood mononuclear cells (PBMCs). Statistical analyses were conducted using gamma generalized linear mixed models (Gamma GLMM). A total of 138 CRC patients were included, 72 from the intervention group and 66 from the control group. The BER activity in the intervention group did not change significantly compared to the control group. Our findings revealed a substantial range in both inter- and intra-individual levels of BER. In conclusion, the results do not support an effect of dietary intervention on BER activity in post-surgery CRC patients during a 6-month intervention period.

• Westerberg, Ane Cecilie; Degnes, Maren-Helene Langeland; Andresen, Ina Jungersen; Roland, Marie Cecilie & Michelsen, Trond Melbye (2024). Angiogenic and vasoactive proteins in the maternal-fetal interface in healthy pregnancies and preeclampsia. American Journal of Obstetrics and Gynecology. ISSN 0002-9378. doi: 10.1016/j.ajog.2024.03.012.
• Grindedal, Eli Marie; Zucknick, Manuela; Stormorken, Astrid T.; Rønne, Elin; Tandstad, Nora Martinussen & Isaacs, William B. [Show all 8 contributors for this article] (2024). Outcomes of 10 years of PSA screening for prostate cancer in Norwegian men with Lynch syndrome. The Prostate. ISSN 0270-4137. p. 1–9. doi: 10.1002/pros.24711.
• Wagner, Theresa Maria; Pöntinen, Anna Kaarina; Fenzel, Carolin Kornelia; Engi, Daniel; Janice, Jessin & Almeida-Santos, Ana C. [Show all 12 contributors for this article] (2024). Interactions between commensal Enterococcus faecium and Enterococcus lactis and clinical isolates of Enterococcus faecium. FEMS microbes. 5. doi: 10.1093/femsmc/xtae009.
• Štrumbelj, Erik; Bouchard-Côté, Alexandre; Corander, Jukka; Gelman, Andrew; Rue, Håvard & Murray, Lawrence [Show all 9 contributors for this article] (2024). Past, Present and Future of Software for Bayesian Inference. Statistical Science. ISSN 0883-4237. 39(1), p. 46–61. doi: 10.1214/23-STS907.
• Metzcar, John; Jutzeler, Catherine R.; Macklin, Paul; Luque, Alvaro Kohn & Brüningk, Sarah C. (2024). A review of mechanistic learning in mathematical oncology. Frontiers in Immunology. ISSN 1664-3224. 15. doi: 10.3389/fimmu.2024.1363144.
• Haukeland-Parker, Stacey Marie; Jervan, Øyvind; Ghanima, Waleed; Spruit, Martijn A.; Holst, Rene & Tavoly, Mazdak [Show all 8 contributors for this article] (2024). Physical activity following pulmonary embolism and clinical correlates in selected patients: a cross-sectional study. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 8(2). doi: 10.1016/j.rpth.2024.102366.
• Akman, Tuğba; Arendt, Lisa M.; Geisler, Jürgen; Kristensen, Vessela N.; Frigessi, Arnoldo & Luque, Alvaro Kohn (2024). Modeling of Mouse Experiments Suggests that Optimal Anti-Hormonal Treatment for Breast Cancer is Diet-Dependent. Bulletin of Mathematical Biology. ISSN 0092-8240. 86(4). doi: 10.1007/s11538-023-01253-1.
• Leblanc, Marissa Erin; Williamson, Jon; De Pretis, Francesco; Landes, Jurgen & Rocca, Elena (2024). Individual consent in cluster randomised trials for non-pharmaceutical interventions: going beyond the Ottawa statement. Critical Public Health. ISSN 0958-1596. 34(1). doi: 10.1080/09581596.2024.2338074. Full text in Research Archive
• Xie, Ouli; Morris, Jacqueline M.; Hayes, Andrew J.; Towers, Rebecca J.; Jespersen, Magnus G. & Lees, John A. [Show all 32 contributors for this article] (2024). Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis. Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-46530-2.
• Pripp, Are Hugo (2024). Statistisk analyse av én enkelt pasient. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 144(2). doi: 10.4045/tidsskr.23.0695.
• Ghiasvand, Reza; Green, Adele C.; Veierød, Marit Bragelien & Robsahm, Trude Eid (2024). Incidence and Factors Associated with Second Primary Invasive Melanoma in Norway. JAMA dermatology. ISSN 2168-6068. doi: 10.1001/jamadermatol.2023.6251.
• Alonso-Rodríguez, Noelia; Vianello, Eleonora; van Veen, Suzanne; Jenum, Synne; Tonby, Kristian & van Riessen, Rosalie [Show all 10 contributors for this article] (2024). Whole blood RNA signatures in tuberculosis patients receiving H56:IC31 vaccine as adjunctive therapy. Frontiers in Immunology. ISSN 1664-3224. 15. doi: 10.3389/fimmu.2024.1350593.
• Pleym, Karin; Dammen, Toril; Weedon-Fekjær, Harald; Husebye, Einar; Sverre, Elise Christine Bjørkholen & Tonstad, Serena [Show all 7 contributors for this article] (2024). A multi-component intervention increased access to smoking cessation treatment after hospitalization for atherosclerotic cardiovascular disease: A randomized trial. European Heart Journal Open (EHJ Open). 4(2). doi: 10.1093/ehjopen/oeae028.
• Vázquez Fernández, Liliana; Diz-Lois Palomares, Alfonso; Vicedo Cabrera, Ana M.; De Blasio, Birgitte Freiesleben; Di Ruscio, Francesco & Wisløff, Torbjørn [Show all 7 contributors for this article] (2024). Short-term association between air temperature and mortality in seven cities in Norway: A time series analysis. Scandinavian Journal of Public Health. ISSN 1403-4948. doi: 10.1177/14034948241233359.
• Wu, Chenyu; Gunnarsson, Einar Bjarki; Myklebust, Even Moa; Luque, Alvaro Kohn; Tadele, Dagim Shiferaw & Enserink, Jorrit [Show all 9 contributors for this article] (2024). Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data. PLoS Computational Biology. ISSN 1553-734X. 20(3). doi: 10.1371/journal.pcbi.1011888.
• Lindberg, Nina Kristine Ellefsen; Kynø, Nina M; Feragen, Kristin Judith Billaud; Pripp, Are Hugo & Tønseth, Kim Alexander (2024). Parental Stress, Infant Feeding and Well-being in Families Affected by Cleft Lip and/or Cleft Palate: The Impact of Early Follow-up. The Cleft Palate-Craniofacial Journal. ISSN 1055-6656. doi: 10.1177/10556656241231524.
• Zhao, Zhi; Zobolas, John; Zucknick, Manuela & Aittokallio, Tero Antero (2024). Tutorial on survival modeling with applications to omics data. Bioinformatics. ISSN 1367-4803. 40(3). doi: 10.1093/bioinformatics/btae132.
• Thelle, Dag Steinar & Grønbæk, Morten (2024). Alcohol – a scoping review for Nordic Nutrition Recommendations 2023. Food & Nutrition Research (FNR). ISSN 1654-6628. 68. doi: 10.29219/fnr.v68.10540.
• Bjørneboe, John Andreas; Bratsberg, Andrea Mathisen; Brox, Jens Ivar; Skatteboe, Sigrid; Wilhelmsen, Maja & Samuelsen, Kjetil Magne [Show all 10 contributors for this article] (2024). Symptom burden and follow-up of patients with neck and back complaints in specialized outpatient care: a national register study. Scientific Reports. ISSN 2045-2322. 14(1). doi: 10.1038/s41598-024-53879-3.
• Chan, Yat Hin; Rø, Gunnar; Midtbø, Jørgen E.; Di Ruscio, Francesco; Watle, Sara Sofie Viksmoen & Juvet, Lene Kristine [Show all 19 contributors for this article] (2024). Modeling geographic vaccination strategies for COVID-19 in Norway. PLoS Computational Biology. ISSN 1553-734X. 20(1). doi: 10.1371/journal.pcbi.1011426.
• Plaksienko, Anna; Lena, Pietro Di; Nardini, Christine & Angelini, Claudia (2024). methyLImp2: faster missing value estimation for DNA methylation data. Bioinformatics. ISSN 1367-4803. 40(1). doi: 10.1093/bioinformatics/btae001.
• Helset, Elin; Cheng, Vesa; Sporsem, Hilde Margrete; Thorstensen, Christian; Nordøy, Ingvild & Gammelsrud, Karianne Wiger [Show all 10 contributors for this article] (2024). Meropenem pharmacokinetic/pharmacodynamic target attainment and clinical response in ICU patients: A prospective observational study. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. doi: 10.1111/aas.14376.
• Hov, Brit; Andersen, Tiina Maarit; Toussaint, Michel; Mikalsen, Ingvild Bruun; Vollsæter, Maria & Brunborg, Cathrine [Show all 8 contributors for this article] (2024). Mechanically assisted cough strategies: user perspectives and cough flows in children with neurodisability. European Respiratory Journal Open Research (ERJ Open Research). ISSN 2312-0541. 10(1). doi: 10.1183/23120541.00274-2023.
• Heimersheim, Stefan; Rønneberg, Leiv; Linton, Henry; Pagani, Filippo & Fialkov, Anastasia (2024). FlexKnot and Gaussian Process for 21 cm global signal analysis and foreground separation. Monthly notices of the Royal Astronomical Society. ISSN 0035-8711. 527(4), p. 11404–11421. doi: 10.1093/mnras/stad3936.
• Deng, Wei Hai; Zürcher, Simeon J.; Schindera, Christina; Jung, Ruedi; Hebestreit, Helge & Bänteli, Iris [Show all 10 contributors for this article] (2024). Effect of a 1-year physical activity intervention on quality of life, fatigue, and distress in adult childhood cancer survivors—A randomized controlled trial (SURfit). Cancer. ISSN 0008-543X. doi: 10.1002/cncr.35207.
• Pöntinen, Anna Kaarina; Gladstone, Rebecca Ashley; Pesonen, Henri; Pesonen, Maiju; Cleon, Francois Pierre Alexandre & Parcell, Benjamin J [Show all 14 contributors for this article] (2024). Modulation of multidrug-resistant clone success in Escherichia coli populations: a longitudinal, multi-country, genomic and antibiotic usage cohort study. Lancet Microbe. ISSN 2666-5247. 5(2), p. e142–e150. doi: 10.1016/S2666-5247(23)00292-6.
• Barnoiu, Ovidiu-Spiru; Johannessen, Tom Børge; Diep, Lien My; Pedersen, Eskil Sønvisen; Hjelle, Karin Margrethe & Beisland, Christian (2024). Prediction of clinically significant recurrence after partial nephrectomy. Data from the Cancer Registry of Norway with more than five years of follow-up. Scandinavian Journal of Urology. ISSN 2168-1805. 59, p. 1–9. doi: 10.2340/sju.v59.18674.
• Galtung, Kristina Flor; Lauritzen, Peter Mæhre; Sandbæk, Gunnar; Bay, Dag; Ponzi, Erica & Baco, Eduard [Show all 9 contributors for this article] (2024). Computed tomography for visible haematuria – a single nephrographic phase is sufficient for detecting renal cell carcinoma. Scandinavian Journal of Urology. ISSN 2168-1805. 59, p. 10–18. doi: 10.2340/sju.v59.18467.
• Eide, Nils; Faber, Rowan Thomas; Garred, Øystein; Falk, Ragnhild Sørum & Robsahm, Trude Eid (2024). Characterizations of uveal melanoma patients with three additional primary malignancies. Acta Ophthalmologica. ISSN 1755-375X. doi: 10.1111/aos.16631.
• Patrick-Brown, Dawn Judith; Trøseid, Marius & Olsen, Inge Christoffer (2024). Experiences and challenges with the new European Clinical Trials Regulation. Trials. ISSN 1745-6215. 25(1). doi: 10.1186/s13063-023-07869-x.
• Sarjomaa, Marjut Anneli; Zhang, Chi; Tveten, Yngvar; Kersten, Hege; Reiso, Harald & Eikeland, Randi [Show all 14 contributors for this article] (2024). Risk factors for SARS-CoV-2 infection: A test-negative case-control study with additional population controls in Norway. BMJ Open. ISSN 2044-6055. 14(1), p. 1–11. doi: 10.1136/bmjopen-2023-073766. Full text in Research Archive Show summary

  Objectives This study aims to assess risk factors for SARS-CoV-2 infection by combined design; first comparing positive cases to negative controls as determined by PCR testing and then comparing these two groups to an additional prepandemic population control group. Design and setting Test-negative design (TND), multicentre case–control study with additional population controls in South-Eastern Norway. Participants Adults who underwent SARS-CoV-2 PCR testing between February and December 2020. PCR-positive cases, PCR-negative controls and additional age-matched population controls. Primary outcome measures The associations between various risk factors based on self- reported questionnaire and SARS-CoV-2 infection comparing PCR-positive cases and PCR-negative controls. Using subgroup analysis, the risk factors for both PCR-positive and PCR-negative participants were compared with a population control group. Results In total, 400 PCR-positive cases, 719 PCR-negative controls and 14 509 population controls were included. Male sex was associated with the risk of SARS-CoV-2 infection only in the TND study (OR 1.9, 95% CI 1.4 to 2.6), but not when PCR-positive cases were compared with population controls (OR 1.2, 95% CI 0.9. to 1.5). Some factors were positively (asthma, wood heating) or negatively (hypertension) associated with SARS-CoV-2 infection when PCR-positive cases were compared with population controls, but lacked convincing association in the TND study. Smoking was negatively associated with the risk of SARS-CoV-2 infection in both analyses (OR 0.5, 95% CI 0.3 to 0.8 and OR 0.6, 95% CI 0.4 to 0.8). Conclusions Male sex was a possible risk factor for SARS-CoV-2 infection only in the TND study, whereas smoking was negatively associated with SARS-CoV-2 infection in both the TND study and when using population controls. Several factors were associated with SARS-CoV-2 infection when PCR-positive cases were compared with population controls, but not in the TND study, highlighting the strength of combining case–control study designs during the pandemic.

• Nordengen, Anne Lene; Kværner, Ane Sørlie; Krutto, Annika; Alavi, Dena Treider; Henriksen, Hege & Henriksen, Christine [Show all 12 contributors for this article] (2023). DNA base oxidation in relation to TNM stages and chemotherapy treatment in colorectal cancer patients 2–9 months post-surgery. Free Radical Biology & Medicine. ISSN 0891-5849. 212, p. 174–185. doi: 10.1016/j.freeradbiomed.2023.12.016. Full text in Research Archive Show summary

  Accumulation of DNA damage is a critical feature of genomic instability, which is a hallmark of various cancers. The enzyme-modified comet assay is a recognised method to detect specific DNA lesions at the level of individual cells. In this cross-sectional investigation, we explore possible links between clinicopathological and treatment related factors, nutritional status, physical activity and function, and DNA damage in a cohort of colorectal cancer (CRC) patients with non-metastatic disease. Levels of DNA damage in peripheral mononuclear blood cells (PBMCs) assessed 2-9 months post-surgery, were compared across tumour stage (localized (stage I-II) vs. regional (stage III) disease), localization (colon vs. rectosigmoid/rectum cancer), and adjuvant chemotherapy usage, with the last dosage administrated 2-191 days prior to sampling. Associations between DNA damage and indicators of nutritional status, physical activity and function were also explored. In PBMCs, DNA base oxidation was higher in patients diagnosed with regional compared with localized tumours (P=0.03), but no difference was seen for DNA strand breaks (P>0.05). Number of days since last chemotherapy dosage was negatively associated with DNA base oxidation (P

• Moltu, Sissel Jennifer; Nordvik, Tone; Rossholt, Madelaine; Wendel, Kristina; Chawla, Maninder Singh & Server, Andrés [Show all 18 contributors for this article] (2023). Arachidonic and docosahexaenoic acid supplementation and brain maturation in preterm infants; a double blind RCT. Clinical Nutrition. ISSN 0261-5614. 43(1), p. 176–186. doi: 10.1016/j.clnu.2023.11.037.
• Eide, Per Kristian; Lashkarivand, Aslan; Pripp, Are Hugo; Valnes, Lars Magnus; Hovd, Markus & Ringstad, Geir [Show all 8 contributors for this article] (2023). Mechanisms behind changes of neurodegeneration biomarkers in plasma induced by sleep deprivation. Brain Communications. ISSN 2632-1297. 5(6). doi: 10.1093/braincomms/fcad343. Full text in Research Archive
• Brynjulvsen, Marit; Solli, Elise; Walewska, Maria; Zucknick, Manuela; Djirackor, Luna & Langmoen, Iver Arne [Show all 10 contributors for this article] (2023). Functional and Molecular Heterogeneity in Glioma Stem Cells Derived from Multiregional Sampling. Cancers. ISSN 2072-6694. 15(24). doi: 10.3390/cancers15245826. Full text in Research Archive
• Perera, M. Prabhavi N.; Mallawaarachchi, Sudaraka; Bailey, Neil W.; Murphy, Oscar W. & Fitzgerald, Paul B. (2023). Obsessive-compulsive disorder (OCD) is associated with increased engagement of frontal brain regions across multiple event-related potentials. Psychological Medicine. ISSN 0033-2917. 53(15), p. 7287–7299. doi: 10.1017/S0033291723000843. Full text in Research Archive
• Babigumira, Ronnie; Veierød, Marit Bragelien; Hosgood, H. Dean; Samuelsen, Sven Ove; Bråtveit, Magne & Kirkeleit, Jorunn [Show all 13 contributors for this article] (2023). Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study. Occupational and Environmental Medicine. ISSN 1351-0711. 81(1). doi: 10.1136/oemed-2023-109139. Full text in Research Archive Show summary

  Objective The objective of our study was to examine whether occupational exposure to benzene is associated with lung cancer among males in the Norwegian Offshore Petroleum Workers cohort. Methods Among 25 347 male offshore workers employed during 1965–1998, we conducted a case-cohort study with 399 lung cancer cases diagnosed between 1999 and 2021, and 2035 non-cases sampled randomly by 5-year birth cohorts. Individual work histories were coupled to study-specific job-exposure matrices for benzene and other known lung carcinogens. Weighted Cox regression was used to estimate HRs and 95% CIs for the associations between benzene exposure and lung cancer, by major histological subtypes, adjusted for age, smoking and occupational exposure to welding fumes, asbestos and crystalline silica. Missing data were imputed. Results For lung cancer (all subtypes combined), HRs (95% CIs) for the highest quartiles of benzene exposure versus unexposed were 1.15 (0.61 to 2.35) for cumulative exposure, 1.43 (0.76 to 2.69) for duration, and 1.22 (0.68 to 2.18) for average intensity (0.280≤P-trend≤0.741). For 152 adenocarcinoma cases, a positive trend was observed for exposure duration (P-trend=0.044). Conclusions In this cohort of offshore petroleum workers generally exposed to low average levels of benzene, we did not find an overall clear support for an association with lung cancer (all subtypes combined), although an association was suggested for duration of benzene exposure and adenocarcinoma. The limited evidence might be due to restricted statistical power.

• Huynh, Thuy-Tien Maria; Dale, Einar; Falk, Ragnhild Sørum; Hellebust, Taran Annette Paulsen; Astrup, Guro Lindviksmoen & Malinen, Eirik [Show all 12 contributors for this article] (2023). Radiation-induced long-term dysphagia in survivors of head and neck cancer and association with dose-volume parameters. Radiotherapy and Oncology. ISSN 0167-8140. 190. doi: 10.1016/j.radonc.2023.110044. Full text in Research Archive
• Vilming, Bente ; Dahl, Jørgen Fallås; Bentzen, Anne Gry; Ingebrigtsen, Vibeke Anett; Nilsen, Elisabeth Berge & Vistad, Ingvild [Show all 12 contributors for this article] (2023). Real-world data on niraparib maintenance treatment in patients with non-gBRCA mutated platinum-sensitive recurrent ovarian cancer. International Journal of Gynecological Cancer. ISSN 1048-891X. 33(12), p. 1898–1905. doi: 10.1136/ijgc-2023-004484. Full text in Research Archive
• Chen, Yingjia; He, Liye; Ianevski, Aleksandr; Ayuda Duran, Pilar; Potdar, Swapnil & Saarela, Jani [Show all 14 contributors for this article] (2023). Robust scoring of selective drug responses for patient-tailored therapy selection. Nature Protocols. ISSN 1754-2189. p. 1–30. doi: 10.1038/s41596-023-00903-x. Full text in Research Archive
• Marjerrison, Niki; Grimsrud, Tom Kristian; Hansen, Johnni; Martinsen, Jan Ivar; Nordby, Karl-Christian & Olsen, Raymond [Show all 8 contributors for this article] (2023). Occupational exposures of firefighting and urinary tract cancer risk among men in the Norwegian Fire Departments Cohort. Occupational and Environmental Medicine. ISSN 1351-0711. 80(12). doi: 10.1136/oemed-2023-109003. Full text in Research Archive Show summary

  Objectives Increased risks of bladder cancer and mesothelioma were the strongest evidence for the recent reclassification of firefighting as carcinogenic (Group 1) by the International Agency for Research on Cancer. Our study aim was to develop indicators for specific firefighting exposures and examine associations with urinary tract cancer (UTC), including bladder cancer. Methods We developed indicators for exposure from employment at a fire department or in firefighting jobs, to fire and smoke, and to diesel exhaust for men in the Norwegian Fire Departments Cohort (n=4250). Incident UTC cases were obtained from the Cancer Registry of Norway (1960–2021). Poisson regression was used to estimate incidence rate ratios (IRR) with cumulative exposures grouped into tertiles (reference: lowest exposed tertile) with 0-year, 10-year and 15-year lagging of exposures. Results During 125 090 person-years of follow-up, there were 76 cases of UTC. IRRs were mostly non-significantly increased in the middle tertile and at or below 1 in the highest tertile for total duration of employment, number of fires attended and fire exposure score with and without lags. In the middle tertile for diesel exhaust exposure, UTC risk was elevated over twofold with 10-year (IRR 2.27, 95% CI 1.22 to 4.20) and 15- year (2.21, 1.18 to 4.16) lags, and near 1 in the highest tertile. Findings for bladder cancer were similar to those for UTC. Conclusions Dose-response associations between the exposure indicators and UTC were not observed. Future studies using the indicators with more cases are needed.

• Nyquist, Emil; Dalgaard, Jakob; Spetalen, Signe; Torkildsen, Synne; Frøen, Hege & Galteland, Eivind [Show all 17 contributors for this article] (2023). Pathogenic DDX41 variants, possible response predictors to low-dose melphalan in hypo- and normocellular MDS and AML. British Journal of Haematology. ISSN 0007-1048. 204(2), p. 724–729. doi: 10.1111/bjh.19226. Full text in Research Archive
• Pereira, Ana P.; Antunes, Patrícia; Bierge, Paula; Willems, Rob J.L.; Corander, Jukka & Coque, Teresa M. [Show all 10 contributors for this article] (2023). Unraveling Enterococcus susceptibility to quaternary ammonium compounds: genes, phenotypes, and the impact of environmental conditions. Microbiology spectrum. ISSN 2165-0497. 11(5). doi: 10.1128/spectrum.02324-23. Full text in Research Archive
• Zhao, Zhi; Banterle, Marco; Lewin, Alex & Zucknick, Manuela (2023). Multivariate Bayesian structured variable selection for pharmacogenomic studies. The Journal of the Royal Statistical Society, Series C (Applied Statistics). ISSN 0035-9254. 73(2), p. 420–443. doi: 10.1093/jrsssc/qlad102. Full text in Research Archive
• Presterud, Rebecca; Deng, Wei Hai; Wennerström, Anna Berit; Burgers, Geertruida Aleida Wilhelmina; Gajera, Bharat & Mattsson, Kirsten G. [Show all 11 contributors for this article] (2023). Long-Term Nicotinamide Riboside Use Improves Coordination and Eye Movements in Ataxia Telangiectasia. Movement Disorders. ISSN 0885-3185. p. 1–11. doi: 10.1002/mds.29645. Full text in Research Archive Show summary

  Background: Supplementation of nicotinamide riboside (NR) ameliorates neuropathology in animal models of ataxia telangiectasia (A-T). In humans, short-term NR supplementation showed benefits in neurological outcome. Objectives: The study aimed to investigate the safety and benefits of long-term NR supplementation in individuals with A-T. Methods: A single-arm, open-label clinical trial was performed in individuals with A-T, receiving NR over a period of 2 years. Biomarkers and clinical examinations were used to assess safety parameters. Standardized and validated neuromotor tests were used to monitor changes in neurological symptoms. Using generalized mixed models, test results were compared to expected disease progression based on historical data. Results: NAD+ concentrations increased rapidly in peripheral blood and stabilized at a higher level than baseline. NR supplementation was well tolerated for most participants. The total scores in the neuromotor test panels, as evaluated at the 18-month time point, improved for all but one participant, primarily driven by improvements in coordination subscores and eye movements. A comparison with historical data revealed that the progression of certain neuromotor symptoms was slower than anticipated. Conclusions: Long-term use of NR appears to be safe and well tolerated, and it improves motor coordination and eye movements in patients with A-T of all ages. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

• Feyling, Anders Christian; Kamalo, Patrick D.; HANCHE-OLSEN, TERJE PEDER; Chikumbanje, Singatiya S.; Zsidek, Aina Sophie & Ponzi, Erica [Show all 7 contributors for this article] (2023). Preventing hypothermia in pediatric neurosurgery in Africa—A randomized controlled non-inferiority trial of insulation versus active warming. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. doi: 10.1111/aas.14341. Full text in Research Archive
• Hsieh, Ping-Han; Lopes-Ramos, Camila Miranda; Zucknick, Manuela; Sandve, Geir Kjetil Ferkingstad; Glass, Kimberly & Kuijjer, Marieke (2023). Adjustment of spurious correlations in co-expression measurements from RNA-Sequencing data. Bioinformatics. ISSN 1367-4803. 39(10). doi: 10.1093/bioinformatics/btad610. Full text in Research Archive
• Calland, Jessica Kate; Haukka, Kaisa; Kpordze, Stephen W; Brusah, Atanyiwoen; Corbella, Marta & Merla, Cristina [Show all 13 contributors for this article] (2023). Population structure and antimicrobial resistance among Klebsiella isolates sampled from human, animal, and environmental sources in Ghana: a cross-sectional genomic One Health study. Lancet Microbe. ISSN 2666-5247. 4(11), p. e943–e952. doi: 10.1016/S2666-5247(23)00208-2. Full text in Research Archive
• Schmutz, Maximilian; Zucknick, Manuela; Schlenk, Richard F.; Mertens, Daniel; Benner, Axel & Weichenhan, Dieter [Show all 11 contributors for this article] (2023). Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen. Clinical Epigenetics. ISSN 1868-7075. 15(1). doi: 10.1186/s13148-023-01580-z. Full text in Research Archive
• Perera, M. Prabhavi N.; Bailey, Neil W.; Murphy, Oscar W.; Mallawaarachchi, Sudaraka; Sullivan, Caley & Hill, Aron T. [Show all 7 contributors for this article] (2023). Home-Based Individualized Alpha Transcranial Alternating Current Stimulation Improves Symptoms of Obsessive-Compulsive Disorder: Preliminary Evidence from a Randomized, Sham-Controlled Clinical Trial. Depression and Anxiety. ISSN 1091-4269. 2023. doi: 10.1155/2023/9958884. Full text in Research Archive
• Hjell, Gabriela; Rokicki, Jaroslav; Szabo, Attila; Holst, Rene; Tesli, Natalia & Bell, Christina [Show all 19 contributors for this article] (2023). Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy. BMC Psychiatry. ISSN 1471-244X. 23(1). doi: 10.1186/s12888-023-05154-4. Full text in Research Archive
• Shahbazyan, Sevak S.; Sahakyan, Mushegh; Gabrielyan, Artak; Lai, Xiaoran; Martirosyan, Aram & Petrosyan, Hmayak [Show all 8 contributors for this article] (2023). Billroth-I anastomosis in distal subtotal gastrectomy for non-early gastric adenocarcinoma. Radiology and Oncology. ISSN 1318-2099. 57(3), p. 356–363. doi: 10.2478/raon-2023-0041. Full text in Research Archive
• Gjersvik, Petter; Falk, Ragnhild Sørum; Roscher, Ingrid; Rizvi, Syed Mohammad Husain; Mjøen, Geir & Gude, Einar [Show all 10 contributors for this article] (2023). Rates of Second Tumor, Metastasis, and Death from Cutaneous Squamous Cell Carcinoma in Patients with and Without Transplant-Associated Immunosuppression. JAMA dermatology. ISSN 2168-6068. 159(9), p. 923–929. doi: 10.1001/jamadermatol.2023.2029.
• Brevik, Thea Beate; da Matta Calegari, Lara Rodrigues; Metcalfe, Isabel Mosquera; Laake, Petter; Maza, Mauricio & Basu, Partha [Show all 8 contributors for this article] (2023). Training health care providers to administer VIA as a screening test for cervical cancer : a systematic review of essential training components. BMC Medical Education. ISSN 1472-6920. 23, p. 1–11. doi: 10.1186/s12909-023-04711-5. Full text in Research Archive Show summary

  Background: Training health care providers to administer visual inspection after application of acetic acid (VIA) is paramount in improving cervical cancer screening services for women in low- and middle-income countries. The objective of this systematic review was to create a framework of essential VIA training components and provide illustrating examples of how VIA training programs can be carried out in different clinical settings. Methods: A systematic review of PubMed, Embase, and Web of Science (from 2006 to 2021) was undertaken. Our inclusion criteria comprised articles reporting on implemented cervical cancer screening programs using VIA in a screen-and-treat approach. Trained health care providers with any level of health education were included, and the outcome of interest was the reporting of training components. Data were extracted by two reviewers, and a narrative synthesis of the training programs was performed. We developed a framework of seven essential training components and applied it to assess how training courses were conducted in different settings. Results: 13 primary studies were eligible for inclusion, including 2,722 trained health care providers and 342,889 screened women. Most training courses lasted 5–7 days and included theoretical education, practical skill development, and competence assessment. It was unclear how visual aids and training in client counselling and quality assessment were integrated in the training courses. After the training course, nearly all the VIA training programs made provisions for on-job training at the providers’ own clinical settings through supervision, feedback, and refresher training. Conclusions: This study demonstrates the feasibility of implementing international training recommendations for cervical cancer screening in real-world settings and provides valuable examples of training program implementation across various clinical settings. The diverse reporting practices of quality indicators in different studies hinder the establishment of direct links between these data and training program effectiveness. To enhance future reporting, authors should emphasize specific training components, delivery methods, and contextual factors. Standardized reporting of quality indicators for effective evaluation of VIA training programs is recommended, fostering comparability, facilitating research, and enhancing reporting quality in this field.

• Rüegg, Corina Silvia; Zürcher, Simeon J.; Schindera, Christina; Jung, Ruedi; Deng, Wei Hai & Bänteli, Iris [Show all 10 contributors for this article] (2023). Effect of a 1-year physical activity intervention on cardiovascular health in long-term childhood cancer survivors—a randomised controlled trial (SURfit). British Journal of Cancer. ISSN 0007-0920. 129, p. 1284–1297. doi: 10.1038/s41416-023-02410-y.
• Saga, Elin; Skovdahl, Kirsti-Iren; Lindholm, Espen; Falk, Ragnhild Sørum & Bing-Jonsson, Pia Cecilie (2023). Development of a Workplace-Based Training Program for Nurse-Led Ultrasound-Guided Femoral Nerve Blocks: A Feasibility Study with the Patients’ Perspective in Focus. Nursing Forum. ISSN 0029-6473. p. 1–11. doi: 10.1155/2023/8810083. Full text in Research Archive Show summary

  Background. Task shifting is a systematic delegation of tasks in order to make more efficient use of the available human resources for health. Training programs and the quality of these are sparsely studied and specially they that include the patients’ perspectives to an even lesser degree. Aim. A single-center feasibility study with a convergent parallel mixed method approach, integrating quantitative and qualitative components, was conducted at an emergency department aimed to evaluate a training program for nurse-led ultrasound-guided femoral nerve block. Method. Registered nurses (RNs) (n = 5), supervising anesthesiologists (n = 7), and patients with hip fracture (n = 15) participated. The training consisted of a one-day program that included comprehensive theoretical and practical instruction in anatomy, hygiene, and the application of ultrasound. The one-day training program was evaluated through an objective structured clinical examination (OSCE). Following that, each registered nurse conducted three supervised procedures in the weeks that followed. These procedures were performed on patients admitted with hip fractures in the emergency department. The patients (n = 15) were interviewed regarding their experiences and perspectives of pain, safety, and information of the procedures in emergency department. Results. In questionnaire, the RNs and anesthesiologists agreed that the training procedures were beneficial for the patients due to pain relief. Pain intensity showed a mean baseline pain score of 6.0 (95% CI 4.9–7.1) decreasing to 2.5 (95% CI 1.4–3.6) at 30 minutes after needle extraction. The interviews revealed that all patients experienced pain relief after the in situ nerve block training procedures as well as they felt safe and taken care of. Conclusions. The training program for nurse-led ultrasound-guided femoral nerve blocks was considered feasible. All included RNs learned the procedure for task shifting in a satisfactory way.

• Schjøth-Iversen, Line; Sahakyan, Mushegh; Lai, Xiaoran & Refsum, Arne (2023). Laparoscopic vs open repair for primary midline ventral hernia: a prospective cohort study. Langenbeck's Archives of Surgery. ISSN 1435-2443. 408(1). doi: 10.1007/s00423-023-02958-6. Full text in Research Archive
• Jervan, Øyvind; Haukeland-Parker, Stacey Marie; Gleditsch, Jostein; Tavoly, Mazdak; Klok, Frederikus A. & Steine, Kjetil [Show all 14 contributors for this article] (2023). The Effects of Exercise Training in Patients With Persistent Dyspnea Following Pulmonary Embolism: A Randomized Controlled Trial. Chest. ISSN 0012-3692. 164(4), p. 981–991. doi: 10.1016/j.chest.2023.04.042. Full text in Research Archive
• Choi, Hye Jung; Leblanc, Marissa Erin; Moger, Tron Anders; Valberg, Morten; Page, Christian Magnus & Aamodt, Geir [Show all 7 contributors for this article] (2023). Geographical variation in cardiovascular disease mortality in Norway: The role of life course socioeconomic position and parental health. Health and Place. ISSN 1353-8292. 83. doi: 10.1016/j.healthplace.2023.103095. Full text in Research Archive Show summary

  Despite substantial geographical variation in cardiovascular (CVD) mortality within countries, little is known about whether this variation can be explained by individuals' life course socioeconomic position (SEP) or differences in family history of premature CVD deaths. Cox proportional hazards models were used to investigate the association between the county of residence at ages 50–59 and CVD death in Norwegians born between 1940 and 1959 and survived to at least age 60, using national data. Individual life course SEP and family history of premature CVD death reduced the geographical variation in CVD mortality across Norwegian counties, but some significant differences remained. Furthermore, CVD risk varied by residents' migration histories between two counties with distinct CVD and socioeconomic profiles.

• Alonso, Sergio Arredondo; Gladstone, Rebecca Ashley; Pöntinen, Anna Kaarina; Gama, João Alves; Schürch, Anita C. & Lanza, Val F. [Show all 10 contributors for this article] (2023). Mge-cluster: a reference-free approach for typing bacterial plasmids. NAR Genomics and Bioinformatics. ISSN 2631-9268. 5(3). doi: 10.1093/nargab/lqad066. Full text in Research Archive
• Vigeland, Maria Dehli; Flåm, Siri Tennebø; Vigeland, Magnus Dehli; Espeland, Ansgar; Zucknick, Manuela & Wigemyr, Monica [Show all 14 contributors for this article] (2023). Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes. Antibiotics. ISSN 2079-6382. 12(7). doi: 10.3390/antibiotics12071217. Full text in Research Archive

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• Moseid, Nils Fredrik Holm; Lemyre, Nicolas; Roberts, Glyn; Fagerland, Morten Wang; Moseid, Christine Holm & Bahr, Roald (2024). No Pain No Gain: Associations Between Health Problems, Motivation and Coach Relation.
• Grønvold, Lars Alexander Bergene; Forsmo, Håvard Mjørud; Pfeffer, Frank; Norderval, Stig; Sjo, Ole Helmer & Brunborg, Cathrine [Show all 8 contributors for this article] (2024). Aggregated 1-year complication rates and health-related quality of life after reconstructive surgery for rectal cancer with or without diverting stoma (Norwegian Stoma Trial): a protocol for national multicentre, open-label, prospective cohort study. BJS Open. ISSN 2474-9842. 8(1). doi: 10.1093/bjsopen/zrae010.
• Forslund, Marit Vindal; Borgen, Ida Maria Henriksen; Karic, Tanja; Kleffelgård, Ingerid; Hauger, Solveig Lægreid & Løvstad, Marianne [Show all 11 contributors for this article] (2024). Validity of the Norwegian Version of the Needs and Provision Complexity Scale (NPCS) in Patients with Traumatic Brain Injury and Atraumatic Subarachnoid Hemorrhage. Journal of Clinical Medicine. ISSN 2077-0383. 13(3). doi: 10.3390/jcm13030752.
• Frigessi, Arnoldo (2024). Kunstig intelligens for anestesiforskning og praksis .
• Frigessi, Arnoldo (2024). Supporting the AI revolution.
• Nilsen, Kristian Bernhard; Lie, Marie Udnesseter; Andries, Aristomo Ibnu Chalid; Dunker, Øystein; Do, Hoang Oanh Pauline & Reiner, Andrew Henry [Show all 10 contributors for this article] (2023). The DIGMINE project – Improved diagnostics by digital gold mining in historical neurophysiological data. Clinical Neurophysiology. ISSN 1388-2457. doi: 10.1016/j.clinph.2023.03.090.
• Rimal, Raju; Robsahm, Trude Eid; Green, Adele C.; Ghiasvand, Reza; Rueegg, Corina Silvia & Bassarova, Assia Vassileva [Show all 12 contributors for this article] (2023). Melanoma survival by tumour thickness in Norway, 1983–2019.
• Vigdal, Ørjan Nesse; Storheim, Kjersti; Killingmo, Rikke Munk; Rysstad, Tarjei Langseth; Pripp, Are Hugo & van der Gaag, Wendelien [Show all 9 contributors for this article] (2023). . External validation and updating of prognostic prediction models for nonrecovery among older adults seeking primary care for back pain.
• Frigessi, Arnoldo (2023). From limited patient data, to high frequency synthetic data, to the differential equation of a breast tumour growth.
• Frigessi, Arnoldo (2023). The AI algorithm that you are using has its own agenda: you might want to know it. .
• Frigessi, Arnoldo (2023). AI i medisin og klinikk.
• Frigessi, Arnoldo (2023). Kunstig intelligens, algoritmer i klinisk praksis, hvor er vi, hva skjer nå, muligheter og utfordringer .
• Frigessi, Arnoldo (2023). Pair copula constructions in machine learning.
• Frigessi, Arnoldo (2023). The AI ecosystem.
• Przybyła, Weronika; Trøen, Gunhild; Lai, Xiaoran; Samarakoon, Pubudu Saneth; Kaveh, Fatemeh & Hovig, Eivind [Show all 8 contributors for this article] (2023). Comparative whole genome copy number analysis of disseminated tumor cells and the primary tumor in high-risk neuroblastoma.
• Taraldsen, Kristin; Bjerk, Maria; Linnerud, Siv; Solli, Rune; Brovold, Therese & Olsen, Nina Rydland [Show all 12 contributors for this article] (2023). Implementation of National Advice on Falls Prevention in Municipalities in Norway – The FALLPREVENT Research Project.
• Døsen, Liv Kari; TarAngen, Magnus; Gay, Caryl; Pripp, Are Hugo & Shiryaeva, Olga (2023). Resultater av septumplastikk- klinisk relevans.
• Frigessi, Arnoldo (2023). Hjernen i sentrum: Kunstig intelligens Hva er best; kunstig eller ekte intelligens? .
• Simonsen, Cecilia Smith; Flemmen, Heidi Øyen; Broch, Line; Myklebust, Harald; Berg-Hansen, Pål & Brunborg, Cathrine [Show all 7 contributors for this article] (2023). The association between menopause and multiple sclerosis in a Norwegian MS cohort.
• Krogstie, John; Storsul, Tanja; Frigessi, Arnoldo; Lyngstad, Cathrine Pihl; Andreassen, Eirik & Martinkenaite, Ieva [Show all 13 contributors for this article] (2023). Overordnede tiltak - Andre notat fra rådgivende ekspertgruppe for KI-satsingen. Norges forskningsråd.
• Storsul, Tanja; Rettberg, Jill Walker; Brandtzæg, Petter Bae; Frigessi, Arnoldo; Strumke, Inga & Mahler, Tobias [Show all 12 contributors for this article] (2023). 1. notat fra rådgivende ekspertgruppe for KI-satsingen: Nåsituasjon og forventninger. Forskningsrådet.
• Killingmo, Rikke Munk; Øiestad, Britt Elin; Tveter, Anne Therese; Pripp, Are Hugo; Maas, Esther & Aanesen, Fiona [Show all 9 contributors for this article] (2023). Statistical analysis plan (SAP) for: Modifiable prognostic factors of high costs related to healthcare utilization and productivity loss among people on sick leave due to musculoskeletal disorders – an external validation study (working title). ClinicalTrials.gov .

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