Cardiometabolic disease – pathways, biomarkers, personalised medicine

Key dates: 

Programme

Thursday, October 31

09:00 Registration, poster set-up

10:00 Workshop opening by Jens Petter Berg, Pro-Dean for Research, Medical Faculty, University of Oslo

10:10 Welcome, Stine M. Ulven, local host, University of Oslo

Chair: Hanne C Bertram, Aarhus University

10:15 - 11:45 Session 1 – Metabolomics in cardiometabolic diseases

Invited talk 1 (30 min.) - Gabi Kastenmüller, Helmholtz Zentrum München, GER: Using metabolomics to identify and stratify people for better risk prediction

Invited talk 2 (30 min.) - Rikard Landberg, Chalmers University of Technology, SWE: Integrative metabolomics and proteomics to reflect lifestyle patterns related to T2D

Abstract talk 1 (15 min.) - Naba Al-Sari, Steno Diabetes Center DK:
Low carbohydrate diet elevates blood sphingomyelin in people with type 1 diabetes

Abstract talk 2 (15 min.) - Paul R Jones, Norwegian School of Sport Sciences, NOR: Prospective associations of cardiorespiratory fitness and lipoprotein subclasses in a cohort of Norwegian schoolchildren: the Active Smarter Kids (ASK) study
 

11:45 – 12:15 Coffee break and posters

Chair: Lars O Dragsted, University of Copenhagen

12:15 – 13:15 Session 2 – Metabolomics in gut-liver-host communication

Invited talk 3 (30 min.) – Henrik Munch Roager, University of Copenhagen, DK: Metabolomics to elucidate gut microbial-host interactions important for health

Abstract talk 3 (15 min.) - Vibeke Telle-Hansen, Oslo Metropolitan University, NOR: Comprehensive metabolic profiling supports that metabolically healthy obese subjects have intermediate-stage cardiovascular disease risk compared with normal weight and at-risk obese subjects

Abstract talk 4 (15 min.) -Topi Meuronen, University of Eastern Finland, FIN: LC-MS metabolic profiling of pig heart tissue after whole grain enriched feeding

 
13:15 -14:15   Lunch and posters
 

Chair: Kirsten Holven, University of Oslo
14:15 – 16:00 Session 3 – THS symposium-Nutrition and metabolomics

Invited talk 4 (30 min.) - Jose Ordovas, Tufts University, US:
Use of metabolomics to understand the role of diet on CVD risk

Invited talk 5 (30 min.) - Kati Hanhineva, University of Eastern Finland:
Non-targeted metabolomics in whole grain research

Invited talk 6 (30 min.) - Marc Gunter, International agency for research on cancer, FRA: Diet, metabolic health and cancer: metabolomics studies in population-based cohorts

Young investigator (15min.) - Jacob J Christensen, University of Oslo, NOR: Diet-derived fruit and vegetable metabolites suggest sex-specific mechanisms conferring protection against osteoporosis in humans

16:00 – 16:30 Coffee break and posters

Chair: Thomas Moritz, Swedish University of Agricultural Sciences

16:30-18:00 Session 4-Use of metabolomics in diagnosis

Invited talk 7 (30 min.) - Katja Benedikte Prestø Elgstøen, Oslo University Hospital, NOR: Untargeted metabolomics in body fluids for research and diagnostics in a clinical setting

Invited talk 8 (30 min.) - Hannele Yki-Järvinen, University of Helsinki, FIN: Use of lipidomics to reveal two major forms of Non-Alcoholic Fatty Liver disease

Abstract talk 5 (15 min.) - Aidan McGlinchey, Örebro University, SWE:
Metabolomics approaches in non-alcoholic fatty liver disease

Abstract talk 6 (15 min.) - Olle Hartvigsson, Chalmers University of Technology, SWE: Differences in metabolic profiles in venous and arterial cord blood
 

Chair: Matej Oresic, Örebro University

18:00 – 19:00 Session 5 – Industry session

Sponsored talk 1 (15 min.) - Paul Baker, Avanti Polar Lipids, US:
The Analysis of Oxidized, Complex Lipids: Assessing Oxidation in PUFA-Rich Natural Lipid Extracts

Sponsored talk 2 (15 min.) - Ørjan Espeseth, Matriks, NOR:

Solutions to Accelerate Metabolomics Research

Sponsored talk 3 (15 min.) - Adrian McCann, Bevital, NOR:
Targeted metabolomics including direct and functional biomarkers of vitamin and nutritional status, inflammation and lifestyle

Sponsored talk 4 (15 min.) - Peter Würtz, Nightingale health. FIN:

Affordable metabolomics for large cohorts and trials

20:00 Conference dinner at the Opera house in Oslo city center

Friday, November 1

0900– 14:00 Workshop-Clinical lipidomics (organized by Matej Oresic and Tuulia Hyötyläinen)

Lecturers

* Tuulia Hyötyläinen (Örebro University, Sweden)

* Paul Baker (Avanti Polar Lipids, USA)

* David Broadhurst (Edith Cowan University, Australia)

* Matej Oresic (University of Turku, Finland and Örebro University)

 9:00 Analytical and biological factors affecting the lipidomes. Sampling and sample preparation for lipidomics (Tuulia Hyötyläinen)

9:45 The Challenges of Quantitative Lipidomics: Analytical Methodology and Internal Standard Strategies (Paul Baker)

11:00 -12:00   Lunch and posters

12:00 – 12:45 Lipidomics data processing (Matej Oresic)

12:45 – 14:00 Better Data by Design: The critical roles of experimental design, quality assurance, and post-hoc statistical model assessment, in lipidomics and metabolomics (David Broadhurst)