The University of Oslo is closed and the public defence will be held as a video conference over Zoom.
The defence will follow regular procedure as far as possible, hence it will be open to the public and the audience can ask ex auditorio questions when invited to do so.
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Digital Trial Lecture - chosen topic - time and place
See Digital Trial Lecture on a chosen topic
Digital Trial Lecture - given topic - time and place
See Digital Trial Lecture on a given topic
Adjudication committee
- First opponent: Professor Saveiro Cinti, University of Politecnica delle Marche, Italy
- Second opponent: Professor Gunnar Mellgren, University of Bergen
- Third member and chair of the evaluation committee: Professor Kristin Austlid Tasken, University of Oslo
Chair of the Defence
Professor Emeritus Tore Henriksen, University of Oslo
Principal Supervisor
Professor Christian A. Drevon, University of Oslo
Summary
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. Insulin resistance is a key pathophysiological processes involved in diabetes mellitus type 2, one of the most prevalent and costly non-infectious diseases. Physical exercise is a cornerstone in preventing and treating diabetes mellitus type 2 by its substantial effects on insulin resistance. We analysed normal weight normoglycemic and overweight dysglycemic men before and after acute, long-term and acute upon long-term intensive exercise, focusing on three key insulin target tissues: skeletal muscle, liver, and white adipose, as well as blood. We considered the critical and underappreciated role of tissue crosstalk in whole body insulin action, especially the non-cell autonomous factors proposed to induce insulin resistance, including inflammatory mediators, sulphur- and branched-chain amino acids, adipokines, and hepatokines.
Additional information
Contact the research support staff.