The public defence will be held as a video conference over Zoom.
The defence will follow regular procedure as far as possible, hence it will be open to the public and the audience can ask ex auditorio questions when invited to do so.
Click here to participate in the public defence
Due to copyright reasons, an electronic copy of the thesis must be ordered from the faculty. In order for the faculty to have time to process the order, it must be received by the faculty no later than 2 days prior to the public defence. Orders received later than 2 days before the defence will not be processed. Inquiries regarding the thesis after the public defence must be addressed to the candidate.
Digital Trial Lecture – time and place
Adjudication committee
- First opponent: Senior lecturer Samira Saadoun, St. George's University
- Second opponent: Professor Masato Yasui, School of Medicine, Keito University
- Third member and chair of the evaluation committee: Professor Kåre-Olav Stensløkken, University of Oslo
Chair of the Defence
Professor Lars Nilsson, University of Oslo
Principal Supervisor
Professor Mahmood Amiry-Moghaddam, University of Oslo
Summary
Homeostasis is necessary for normal brain function. Among many anatomical and physiological factors correlated to brain homeostasis, glial cells and in particular astrocytes, play a key role in the brain water and ion homeostasis. The homeostatic mechanisms for which astrocytes are responsible, are critically dependent on astrocyte`s polarization.
Loss of macroglial polarization may have a pivotal effect in different pathophysiological events common to many neurological conditions. Using targeted deletion of astroglial gap junctions (Connexin 43 and 30) as well as the availability of a novel mouse line with a targeted disruption of the β1-syntrophin gene enabled us to explore the anchoring mechanism for AQP4 and Kir4.1 in the CNS. All over, this thesis has unraveled anchoring mechanisms for Kir4.1 and AQP4 and demonstrated an interdependency of AQP4 and connexins when it comes to their expression levels. Taken together our results have provided new insights in the molecular machinery that governs ion and water homeostasis in brain.
Additional information
Contact the research support staff.