Due to copyright issues, an electronic copy of the thesis must be ordered from the faculty. For the faculty to have time to process the order, the order must be received by the faculty at the latest 2 days before the public defence. Orders received later than 2 days before the defence will not be processed. After the public defence, please address any inquiries regarding the thesis to the candidate.
Trial Lecture – time and place
See Trial Lecture.
Adjudication committee
- First opponent: Professor Martin Hallbeck, Linköping University, Sweden
- Second opponent: Associate Professor Per Nilsson, Karolinska Institutet, Sweden
- Third member and chair of the evaluation committee: Professor Anne Gjøen Simonsen, University of Oslo
Chair of the Defence
Associate Professor Johanne Egge Rinholm, University of Oslo
Principal Supervisor
Associate Professor Reidun Torp, University of Oslo
Summary
Alzheimer’s Disease (AD) is the major cause of dementia, and abnormal amyloid-β (Aβ) protein is the main component of the pathological plaques found in the brain parenchyma of these patients. However, disappointing results from many clinical trials have made it clear that Aβ alone cannot explain the pathogenesis of the disease. Multiple factors are today considered to contribute to Aβ pathology, and the aim of Skaaraas’ doctoral thesis was to explore the disease from a hormonal, vascular and neuromodulatory angle to gain a deeper understanding of the role of these factors in AD. Skaaraas has studied the spatial distribution and variance of Aβ plaques and cerebral amyloid angiopathy in the transgenic Arctic Swedish mouse model (tg-ArcSwe). Her studies demonstrate dysfunctional norepinephrine-astrocyte Ca2+ activity in tg-ArcSwe mice, a signaling system of relevance for higher cognitive functions, and provide evidence implicating hormonal and vascular factors in the pathogenesis of AD. These novel results indicate that synergies between several factors are relevant in AD, and that further experimental research may benefit from more multimodal approaches.
Additional information
Contact the research support staff.