To expand our understanding of the frailty syndrome, NutriFrail integrates epidemiological, clinical and basic nutritional research.
The overall objective of NutriFrail is to examine the impact of diet on the progress from healthy to growing frail (from fit to frail) with advancing years, in order to develop new strategies for dietary prevention or delay of frailty progress.
Nutrition and Frailty
Frailty is a geriatric related syndrome characterized by reduced physical function and increased risk of adverse health outcomes when exposed to a stressor (e.g., illness or injury). Within the NutriFrail project, we specifically study the impact of dietary factors on risk of frailty by using data identifying dietary patterns related to frailty and examining the underlying diet-modulated biological pathways for increased risk of frailty associated with growing age.
We use data from two well-established cohorts (The Tromsø study and the Amarone study), and integrate dietary intake data and various adiposity measures with repeated longitudinal measurements of the transcriptome, applying novel methodologies. Further, we conduct complementary mouse models to enhance our understanding of the molecular pathways underlying age-related frailty.
Objectives
Our goal is to gain a deeper understanding of how diet influences the development of frailty in older adults.
We will achieve this by
- identifying food and food patterns that can predict frailty in older adults in both short and long terms, while also considering anthropometry
- revealing the underlying diet-modulated biological pathways for increased risk of frailty, focusing on inflammatory patterns and molecular signatures based on gene expression
Financing
- The Throne Holst Foundation
- Institute of Basic Medical Sciences, University of Oslo
- Aktieselskabet Freia Chocolade Fabriks Medisinske fond
Start – finish
2019 - 2025
Cooperation
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