Arne Olav Melleby

• Ruud, Marianne; Frisk, Michael; Melleby, Arne Olav; Norseng, Per Andreas; Mohamed, Belal A. & Li, Jia [Vis alle 22 forfattere av denne artikkelen] (2024). Regulation of cardiomyocyte t-tubule structure by preload and afterload: Roles in cardiac compensation and decompensation. Journal of Physiology. ISSN 0022-3751. doi: 10.1113/JP284566.
• Sasi, Athiramol; Romaine, Andreas; Murugan Erusappan, Pugazendhi; Melleby, Arne Olav; Hasic, Almira & Dahl, Christen Peder [Vis alle 14 forfattere av denne artikkelen] (2023). Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development. Matrix Biology Plus. 19-20. doi: 10.1016/j.mbplus.2023.100135. Fulltekst i vitenarkiv
• Vistnes, Maria; Murugan Erusappan, Pugazendhi; Sasi, Athiramol; Nordén, Einar Sjaastad; Bergo, Kaja Knudsen & Romaine, Andreas [Vis alle 22 forfattere av denne artikkelen] (2023). Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction. Cardiovascular Research (CVR). ISSN 0008-6363. 119(10), s. 1915–1927. doi: 10.1093/cvr/cvad078. Fulltekst i vitenarkiv
• Skogestad, Jonas; Albert, Ingrid; Hougen, Karina; Lothe, Gustav B; Lunde, Marianne & Eken, Olav Søvik [Vis alle 25 forfattere av denne artikkelen] (2023). Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice with Chronic Heart Failure. Circulation. ISSN 0009-7322. 147(16), s. 1221–1236. doi: 10.1161/CIRCULATIONAHA.121.054168.
• Rypdal, Karoline Bjarnesdatter; Melleby, Arne Olav; Robinson, Emma Louise; Li, Jia; Palmero, Sheryl & Deborah E., Seifert [Vis alle 20 forfattere av denne artikkelen] (2022). ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload. Communications Biology. ISSN 2399-3642. 5(1). doi: 10.1038/s42003-022-04361-1. Fulltekst i vitenarkiv
• Lunde, Ida Gjervold; Aronsen, Jan Magnus; Melleby, Arne Olav; Strand, Mari Elen; Skogestad, Jonas & Bendiksen, Bård Andre [Vis alle 11 forfattere av denne artikkelen] (2022). Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy. Molecular Biology Reports. ISSN 0301-4851. 49(12), s. 11795–11809. doi: 10.1007/s11033-022-07985-y. Fulltekst i vitenarkiv
• Manfra, Ornella; Calamera, Gaia; Froese, Alexander; Arunthavarajah, Dulasi; Surdo, Nicoletta C. & Meier, Silja [Vis alle 14 forfattere av denne artikkelen] (2022). CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors. Cardiovascular Research (CVR). ISSN 0008-6363. 118(6), s. 1506–1519. doi: 10.1093/cvr/cvab167. Fulltekst i vitenarkiv
• Romaine, Andreas; Melleby, Arne Olav; Alam, Jahedul; Lobert, Viola; Lu, Ning & Lockwood, Francesca Eve [Vis alle 13 forfattere av denne artikkelen] (2022). Integrin α11β1 and syndecan-4 dual receptor ablation attenuates cardiac hypertrophy in the pressure overloaded heart. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 322(6), s. H1057–H1071. doi: 10.1152/ajpheart.00635.2021.
• Tønnessen, Theis Christian; Melleby, Arne Olav; Hauge-Iversen, Ida Marie; Espe, Emil Knut Stenersen; Ahmed, Muhammad Shakil & Ueland, Thor [Vis alle 12 forfattere av denne artikkelen] (2022). Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice. PLOS ONE. ISSN 1932-6203. 17(1). doi: 10.1371/journal.pone.0262821. Fulltekst i vitenarkiv Vis sammendrag

  Aims Patients with rheumatoid arthritis (RA) have increased risk of heart failure (HF). The mechanisms and cardiac prerequisites explaining this association remain unresolved. In this study, we sought to determine the potential cardiac impact of an experimental model of RA in mice subjected to HF by constriction of the ascending aorta. Methods Aorta was constricted via thoracotomy and placement of o-rings with inner diameter 0.55 mm or 0.66 mm, or sham operated. RA-like phenotype was instigated by delayed-type hypersensitivity arthritis (DTHA) two weeks after surgery and re-iterated after additional 18 days. Cardiac magnetic resonance imaging (MRI) was performed before surgery and at successive time points throughout the study. Six weeks after surgery the mice were euthanized, blood and tissue were collected, organ weights were documented, and expression levels of cardiac foetal genes were analysed. In a supplemental study, DTHA-mice were euthanized throughout 14 days after induction of arthritis, and blood was analysed for important markers and mediators of RA (SAP, TNF-α and IL-6). In order to put the latter findings into clinical context, the same molecules were analysed in serum from untreated RA patients and compared to healthy controls. Results Significant elevations of inflammatory markers were found in both patient- and murine blood. Furthermore, the DTHA model appeared clinically relevant when compared to the inflammatory responses observed in three prespecified RA severity disease states. Two distinct trajectories of cardiac dysfunction and HF development were found using the two o-ring sizes. These differences were consistent by both MRI, organ weights and cardiac foetal gene expression levels. Still, no difference within the HF groups, nor within the sham groups, could be found when DTHA was induced. Conclusion DTHA mediated systemic inflammation did not cause, nor modify HF caused by aortic constriction. This indicates other prerequisites for RA-induced cardiac dysfunction.

• Rypdal, Karoline Bjarnesdatter; Murugan Erusappan, Pugazendhi; Melleby, Arne Olav; Seifert, Deborah E.; Palmero, Sheryl & Strand, Mari Elen [Vis alle 13 forfattere av denne artikkelen] (2021). The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts. Scientific Reports. ISSN 2045-2322. 11(1), s. 1–15. doi: 10.1038/s41598-021-99032-2. Fulltekst i vitenarkiv
• Alam, Jahedul; Musiime, Moses; Romaine, Andreas; Sawant, Mugdha; Melleby, Arne Olav & Lu, Ning [Vis alle 9 forfattere av denne artikkelen] (2020). Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase. Matrix Biology Plus. 8. doi: 10.1016/j.mbplus.2020.100045.
• Melleby, Arne Olav; Sandvik, Guro Katrine; Couturier, Christine Stephanie; Nilsson, Göran Erik & Stecyk, Jonathan Anthony William (2020). H2S-producing enzymes in anoxia-tolerant vertebrates: Effects of cold acclimation, anoxia exposure and reoxygenation on gene and protein expression. Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology. ISSN 1096-4959. 243-244. doi: 10.1016/j.cbpb.2020.110430.
• Herum, Kate Louise Møller; Romaine, Andreas; Wang, Ariel; Melleby, Arne Olav; Strand, Mari Elen & Pacheco, Julian [Vis alle 16 forfattere av denne artikkelen] (2020). Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 9(3). doi: 10.1161/JAHA.119.013518. Fulltekst i vitenarkiv
• Mohammadzadeh, Naiyereh; Melleby, Arne Olav; Palmero, Sheryl; Sjaastad, Ivar; Chakravarti, Shukti & Engebretsen, Kristin V Thunheim [Vis alle 9 forfattere av denne artikkelen] (2020). Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload. Cardiology. ISSN 0008-6312. 145(3), s. 187–198. doi: 10.1159/000505318.
• Melleby, Arne Olav; Romaine, Andreas; Aronsen, Jan Magnus; Veras, Ioanni; Zhang, Lili & Sjaastad, Ivar [Vis alle 8 forfattere av denne artikkelen] (2018). A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice. Cardiovascular Research (CVR). ISSN 0008-6363. doi: 10.1093/cvr/cvy141. Fulltekst i vitenarkiv
• Romaine, Andreas; Sørensen, Ida Wiig; Zeltz, Cedric; Lu, Ning; Erusappan, Pugazendhi Murugan & Melleby, Arne Olav [Vis alle 15 forfattere av denne artikkelen] (2017). Overexpression of integrin α11 induces cardiac fibrosis in mice. Acta Physiologica Scandinavica. ISSN 0001-6772. 222:e13025(2), s. 1–17. doi: 10.1111/apha.12932.
• Melleby, Arne Olav; Strand, Mari Elen; Romaine, Andreas; Herum, Kate Louise Møller; Skrbic, Biljana & Dahl, Christen Peder [Vis alle 11 forfattere av denne artikkelen] (2016). The heparan sulfate proteoglycan glypican-6 is upregulated in the failing heart, and regulates cardiomyocyte growth through ERK1/2 Signaling. PLOS ONE. ISSN 1932-6203. 11(10). doi: 10.1371/journal.pone.0165079.

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• Aronsen, Jan Magnus; Skogestad, Jonas; Albert, Ingrid; Melleby, Arne Olav & Carlson, Cathrine Rein (2023). Response by Aronsen et al to Letter Regarding Article, "Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure". Circulation. ISSN 0009-7322. 148(10), s. 857–858. doi: 10.1161/CIRCULATIONAHA.123.065884.
• Romaine, Andreas; Sørensen, Ida Wiig; Melleby, Arne Olav; Zeltz, Cedric; Zhang, Lili & Bendiksen, Bård Andre [Vis alle 12 forfattere av denne artikkelen] (2016). Overexpression of integrin a11 induces cardiac hypertrophy and fibrosis.
• Melleby, Arne Olav; Strand, Mari Elen; Herum, Kate Louise Møller; Skrbic, Biljana; Dahl, Christen Peder & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2016). Glypican-6 is upregulated in heart failure and mediates cardiomyocyte growth through ERK1/2 signaling.
• Melleby, Arne Olav; Strand, Mari Elen; Herum, Kate Louise Møller; Skrbic, Biljana; Dahl, Christen Peder & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2015). Glypican-6 is increased in experimental and clinical heart failure and might play a role in cardiac fibrosis through BMP4 signalling.
• Melleby, Arne Olav; Strand, Mari Elen; Skrbic, Biljana; Dahl, Christen Peder; Tønnessen, Theis & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2014). Glypican 6 is up-regulated in pressure overload induced pathological left ventricular remodeling, mediates bFGF signaling and may affect cardiac fibrosis development.
• Melleby, Arne Olav; Strand, Mari Elen; Skrbic, Biljana; Dahl, Christen Peder; Tønnessen, Theis & Sjaastad, Ivar [Vis alle 10 forfattere av denne artikkelen] (2014). The heparan sulfate proteoglycan glypican-6 is increased in experimental and clinical heart failure and might play a role in myocardial fibrosis. European Journal of Heart Failure. ISSN 1388-9842. 16, s. 116–116.

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