Karin Toska

• Lee Hansen, Young Bae; Toska, Karin; Lund, Alice; Flatman, Robert & Ceder, Rebecca (2023). Properties and units in the clinical laboratory sciences. Part XXVII: online dynamic NPU manual (IUPAC Technical Report). Pure and Applied Chemistry. ISSN 0033-4545. 95(2), s. 125–131. doi: 10.1515/pac-2021-1109.
• Elsais, Ahmed; Kerty, Emilia; Russell, Kristoffer & Toska, Karin (2022). Does cardiovascular autonomic dysfunction contribute to fatigue in myasthenia gravis? Physiological Research. ISSN 0862-8408. 71, s. 79–91. doi: 10.33549/physiolres.934660. Fulltekst i vitenarkiv
• Johannessen, Karl Arne; Wear, Nina Kristin Steen; Toska, Karin; Hansbø, Morten; Berg, Jens Petter & Fosse, Erik (2021). Pathologic Blood Samples Tolerate Exposure to Vibration and High Turbulence in Simulated Drone Flights, but Plasma Samples Should be Centrifuged after Flight. IEEE Journal of Translational Engineering in Health and Medicine. ISSN 2168-2372. 9. doi: 10.1109/JTEHM.2021.3053172. Fulltekst i vitenarkiv Vis sammendrag

  Objective. Most of the previous studies of drone transport of blood samples examined normal blood samples transported under tranquil air conditions. We studied the effects of 1- and 2-hour drone flights using random vibration and turbulence simulation (10-30 g-force) on blood samples from 16 healthy volunteers and 74 patients with varying diseased. Methods: Thirty-two of the most common analytes were tested. For biochemical analytes, we used plasma collected in lithium heparin tubes with and without separator gel. Gel samples were analyzed for the effect of separation by centrifugation before or after turbulence. Turbulence was simulated in an LDS V8900 high-force shaker using random vibration (range, 5–200 Hz), with samples randomly allocated to 1- or 2-hour flights with 25 or 50 episodes of turbulence from 10 to 30 G. Results: For all hematologic and most biochemical analytes, test results before and after turbulence exposure were similar (bias < 12%, intercepts < 10%). However, aspartate aminotransferase, folate, lactate dehydrogenase and lipid index increased significantly in samples separated by gel and centrifugation prior to vibration and turbulence test. These changes increased form 10 G to 30 G, but were not observed when the samples were separated after vibration and turbulence. Conclusions: Whole blood showed little vulnerability to turbulence, whereas plasma samples separated from blood cells by gel may be significantly influenced by turbulence when separated by spinning before the exposure. Centrifugation of plasma samples collected in tubes with separator gel should be avoided before drone flights that could be subject to turbulence.

• Ho, Ai Van Thuy; Toska, Karin & Wesche, Jarlis (2020). Rapid, Large, and Synchronous Sweat and Cardiovascular Responses Upon Minor Stimuli in Healthy Subjects. Dynamics and Reproducibility. Frontiers in Neurology. ISSN 1664-2295. 11, s. 1–10. doi: 10.3389/fneur.2020.00051. Fulltekst i vitenarkiv Vis sammendrag

  Purpose: The aim of the study was to investigate steady state levels, dynamics and reproducibility of cardiovascular variables and electrodermal activity in different skin areas in response to minor physiological and mental stimuli in healthy subjects in the thermoneutral zone, carried out in high time resolution. Methods: Thirteen healthy subjects underwent experiments on two separate days. Non-invasive electrodermal activity in five different skin areas was measured continuously using a skin conductance method, including resting supine and sitting positions, performing deep inspirations, a mental challenge and being exposed to a sudden loud sound. Blood pressure, heart rate, radial artery blood flow, and skin perfusion were measured simultaneously. Results: Electrodermal activity in the right and left palms was almost identical, with rapid and large increases within a few seconds in response to stimuli, whereas no such significant changes were seen in the face, back, and abdomen. Radial artery blood flow and palmar skin perfusion changed synchronously with electrodermal activity for each stimulus, and were correlated to changes in blood pressure and heart rate. The response patterns in each subject were very similar on the two experimental days. There was very low spontaneous electrodermal activity in the supine position, contrary to the resting sitting position. Conclusion: The electrodermal activity increased rapidly and synchronously in both palms within a few seconds as a response to minor physiological and mental stimuli, synchronous with fluctuations in radial artery blood flow, palmar skin perfusion, and cardiovascular variables. The responses are reproducible from day to day, making them a stable and constant stimuli to be used for studies in patients with hyperhidrosis.

• Holmberg, Anne; Ho, Ai Van Thuy; Fernand, Dmitry; Toska, Karin; Wester, Torjus & Klaastad, Øivind [Vis alle 8 forfattere av denne artikkelen] (2019). Microcirculation and haemodynamics after infraclavicular brachial plexus block using adrenaline as an adjuvant to lidocaine: a randomised, double-blind, crossover study in healthy volunteers. Anaesthesia. ISSN 0003-2409. s. 1–9. doi: 10.1111/anae.14795. Fulltekst i vitenarkiv
• Urdal, Petter; Amundsen, Erik Koldberg; Toska, Karin & Klingenberg, Olav (2014). Automated alarm to detect antigen excess in serum free immunoglobulin light chain kappa and lambda assays. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 74(7), s. 575–581. doi: 10.3109/00365513.2014.915426.
• Bergersen, Tone Kristin; Hoffmann-Vold, Anna-Maria; Midtvedt, Øyvind; Gran, Jan Tore; Mørk, Cato & Toska, Karin [Vis alle 7 forfattere av denne artikkelen] (2014). Dysfunctional arteriovenous anastomoses in hands of systemic sclerosis patients with digital ulcers. Clinical and Experimental Rheumatology. ISSN 0392-856X. 32(6 Suppl 86), s. 53–59.
• Grindheim, Guro ; Estensen, Mette-Lise; Langsæter, Eldrid; Rosseland, Leiv Arne & Toska, Karin (2012). Changes in blood pressure during healthy pregnancy: a longitudinal cohort study. Journal of Hypertension. ISSN 0263-6352. 30(2), s. 342–350. doi: 10.1097/HJH.0b013e32834f0b1c.
• Grindheim, Guro ; Toska, Karin; Estensen, Mette-Lise & Rosseland, Leiv Arne (2012). Changes in pulmonary function during pregnancy: a longitudinal cohort study. BJOG: An International Journal of Obstetrics and Gynaecology. ISSN 1470-0328. 119(1), s. 94–101. doi: 10.1111/j.1471-0528.2011.03158.x.
• Nådland, Inger Helene; Wesche, Jarlis; Sheriff, Don David & Toska, Karin (2011). Does venous insufficiency impair the exercise-induced rise in arterial leg blood flow? Phlebology. ISSN 0268-3555. 26, s. 326–331. doi: 10.1258/phleb.2011.010092.
• Nådland, Inger Helene; Wesche, Jarlis; Sheriff, DD & Toska, Karin (2011). Does the Great Saphenous Vein Stripping Improve Arterial Leg Blood Flow During Exercise? European Journal of Vascular and Endovascular Surgery. ISSN 1078-5884. 41(5), s. 697–703. doi: 10.1016/j.ejvs.2011.01.022.
• Elstad, Maja; Walløe, Lars; Chon, Ki H. & Toska, Karin (2011). Low-frequency fluctuations in heart rate, cardiac output and mean arterial pressure in humans: what are the physiological relationships? Journal of Hypertension. ISSN 0263-6352. 29(7), s. 1327–1336. doi: 10.1097/HJH.0b013e328347a17a.
• Toska, Karin (2010). Handgrip contraction induces a linear increase in arterial pressure by peripheral vasoconstriction, increased heart rate and a decrease in stroke volume. Acta Physiologica. ISSN 1748-1708. 200(3), s. 211–221. doi: 10.1111/j.1748-1716.2010.02144.x.
• Sheriff, Don; Nådland, Inger Helene & Toska, Karin (2010). Retrograde arterial leg blood flow during tilt-back from a head-up posture: importance of capacitive flows when arterial pressure changes. Journal of applied physiology. ISSN 8750-7587. 108(3), s. 533–537. doi: 10.1152/japplphysiol.01184.2009.
• Sheriff, Don; Nådland, Inger Helene & Toska, Karin (2010). Role of sympathetic responses on the hemodynamic consequences of rapid changes in posture in humans. Journal of applied physiology. ISSN 8750-7587. 108(3), s. 523–532. doi: 10.1152/japplphysiol.01185.2009.
• Nådland, Inger Helene; Walløe, Lars & Toska, Karin (2009). Effect of the leg muscle pump on the rise in muscle perfusion during muscle work in humans. European Journal of Applied Physiology. ISSN 1439-6319. 105(6), s. 829–841. doi: 10.1007/s00421-008-0965-6.
• Elstad, Maja; Nådland, Inger Helene; Toska, Karin & Walløe, Lars (2009). Stroke volume decreases during mild dynamic and static exercise in supine humans. Acta Physiologica. ISSN 1748-1708. 195(2), s. 289–300. doi: 10.1111/j.1748-1716.2008.01887.x.
• Sheriff, DD; Nådland, Inger Helene & Toska, Karin (2007). Hemodynamic consequences of rapid changes in posture in humans. Journal of applied physiology. ISSN 8750-7587. 103, s. 452–458. doi: 10.1152/japplphysiol.01190.2006.
• Medbo, JI; Jebens, E; Noddeland, H; Hanem, S & Toska, Karin (2006). Lactate elimination and glycogen resynthesis after intense bicycling. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 66.

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• Toska, Karin (2011). Letter by Toska regarding article, "Biological basis of therapeutic lymphangiogenesis". Circulation. ISSN 0009-7322. 124(24), s. e895–e895. doi: 10.1161/CIRCULATIONAHA.111.035709.
• Elsais, Ahmed; Kerty, Emilia; Russell, Kristoffer & Toska, Karin (2009). Cardiovascular responses during isometric exercise and low-grade head-up tilt-test in patients with myasthenia gravis. European Journal of Neurology. ISSN 1351-5101. 16, s. 373–373.
• Elstad, Maja & Toska, Karin (2006). Point: Counterpoint: Cardiovascular variability is/is not an index of autonomic control of circulation. Journal of applied physiology. ISSN 8750-7587. 101, s. 687–687.

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