Leon Alexander Mclaren Berge

• Shala, Nita Kaupang; Stenehjem, Jo; Babigumira, Ronnie; Liu, Fei-Chih; Berge, Leon Alexander Mclaren & Silverman, Debra T. [Vis alle 16 forfattere av denne artikkelen] (2023). Exposure to benzene and other hydrocarbons and risk of bladder cancer among male offshore petroleum workers. British Journal of Cancer. ISSN 0007-0920. 129(5), s. 838–851. doi: 10.1038/s41416-023-02357-0. Fulltekst i vitenarkiv Vis sammendrag

  Background Occupational exposures constitute the second leading cause of urinary bladder cancer after tobacco smoking. Increased risks have been found in the petroleum industry, but high-quality exposure data are needed to explain these observations. Methods Using a prospective case-cohort design, we analysed 189 bladder cancer cases (1999–2017) and 2065 randomly drawn non-cases from the Norwegian Offshore Petroleum Workers cohort. Cases were identified in the Cancer Registry of Norway, while work histories (1965–1998) and lifestyle factors were recorded by questionnaire at baseline (1998). Occupational petroleum-related hydrocarbon exposures were assessed by expert-developed job-exposure matrices. Hazard ratios were estimated by weighted Cox-regressions, adjusted for age, tobacco smoking, education, and year of first employment, and with lagged exposures. Results Increased risks were found in benzene-exposed workers, either long-term exposure (≥18.8 years, HR = 1.89, 95% CI: 1.14–3.13; p-trend = 0.044) or high-level cumulative benzene exposure (HR = 1.60, 95% CI: 0.97–2.63; p-trend = 0.065), compared with the unexposed. Associations persisted with 20-year exposure lag. No associations were found with skin or inhalation exposure to crude oil, mineral oil (lubrication, hydraulics, turbines, drilling), or diesel exhaust. Conclusions The results suggest that exposures in the benzene fraction of the petroleum stream may be associated with increased bladder cancer risk.

• Ghiasvand, Reza; Berge, Leon Alexander Mclaren; Kulle, Bettina; Green, Adele C.; Al Rahmoun, Marie & Fournier, Agnès [Vis alle 9 forfattere av denne artikkelen] (2023). Statin use and risk of cutaneous melanoma: a nationwide nested case-control study. British Journal of Dermatology. ISSN 0007-0963. 188(6), s. 805–807. doi: 10.1093/bjd/ljad057. Fulltekst i vitenarkiv
• Berge, Leon Alexander Mclaren; Liu, Fei-Chih; Grimsrud, Tom Kristian; Babigumira, Ronnie; Støer, Nathalie Charlotte & Kjærheim, Kristina [Vis alle 15 forfattere av denne artikkelen] (2022). Night shift work and risk of aggressive prostate cancer in the Norwegian Offshore Petroleum Workers (NOPW) cohort. International Journal of Epidemiology. ISSN 0300-5771. 52(4), s. 1003–1014. doi: 10.1093/ije/dyac235. Fulltekst i vitenarkiv Vis sammendrag

  Background: Night shift work may acutely disrupt the circadian rhythm, with possible carcinogenic effects. Prostate cancer has few established risk factors though night shift work, a probable human carcinogen, may increase the risk. We aimed to study the association between night shift work and chlorinated degreasing agents (CDAs) as possible endocrine disrupters in relation to aggressive prostate cancer as verified malignancies. Methods: We conducted a case-cohort study on 299 aggressive prostate cancer cases and 2056 randomly drawn non-cases in the Norwegian Offshore Petroleum Workers cohort (1965-98) with linkage to the Cancer Registry of Norway (1953-2019). Work history was recorded as years with day, night, and rollover (rotating) shift work, and CDA exposure was assessed with expert-made job-exposure matrices. Weighted Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for aggressive prostate cancer, adjusted for education and year of first employment, stratified by 10-year birth cohorts, and with 10, 15, and 20 years of exposure lag periods. Results: Compared with day work only, an increased hazard of aggressive prostate cancer (HR = 1.86, 95% CI 1.18-2.91; P-trend = 0.046) was found in workers exposed to ≥19.5 years of rollover shift work. This persisted with longer lag periods (HR = 1.90, 95% CI 0.92-3.95; P-trend = 0.007). The exposure-hazard curve for a non-linear model increased linearly (HRs ≥1.00) for 18-26 years of rollover shift work. No association was found with CDA exposure. Conclusions: Long-term exposure to rollover shift work may increase the hazard of aggressive prostate cancer in offshore petroleum workers.

• Ghiasvand, Reza; Berge, Leon Alexander Mclaren; Kulle, Bettina; Stenehjem, Jo Steinson; Heir, Trond & Karlstad, Øystein [Vis alle 11 forfattere av denne artikkelen] (2022). Use of antihypertensive drugs and risk of cutaneous melanoma: A nationwide nested case-control study. International Journal of Epidemiology. ISSN 0300-5771. 52(3), s. 887–898. doi: 10.1093/ije/dyac223. Fulltekst i vitenarkiv
• Berge, Leon Alexander Mclaren; Grimsrud, Tom Kristian; Babigumira, Ronnie; Støer, Nathalie Charlotte; Shala, Nita Kaupang & Veierød, Marit Bragelien [Vis alle 7 forfattere av denne artikkelen] (2022). Cancer epidemiology in practice: Working notes on cancer history-based selection and censoring. Norsk Epidemiologi. ISSN 0803-2491. 30(1-2), s. 107–112. doi: 10.5324/nje.v30i1-2.4986. Fulltekst i vitenarkiv Vis sammendrag

  Researchers conducting observational studies of exposure-cancer associations must make decisions regarding the selection and censoring of study subjects with respect to their cancer history. Given available information, this may include cancers prior to start of follow-up (prevalent cases), and multiple primary cancers (MPCs) at the same or different time-points during follow-up. The choice of analytical strategy may have implications for statistical power and for potential biases. We discuss herein two approaches, the “all cancer approach” and the “first primary cancer approach”. Each contains a set of criteria, primarily for, but not limited to, cohort studies of exposure-cancer associations. Both approaches exclude subjects with prevalent cancers at start of follow-up to avoid information and selection bias but differ in terms of case definition and censoring criteria. In the “all cancer approach”, subjects are censored on non-eligible cancer subtypes of the cancer under study, though subjects with MPCs are not censored on other incident cancers preceding or occurring simultaneously (at time of diagnosis) with the cancer under study. To limit the influence of prior treatment regimens, the “first primary cancer approach” censors subjects upon any first primary incident cancer not under study, including any “simultaneous” MPCs, as well as non-eligible subtypes of the cancer under study. Depending on the cancer under study, these approaches may yield different estimates of the exposure-cancer association and may in this regard be utilized for sensitivity analyses. These alternative approaches are presented and discussed here as a potential resource and source of further discussion for peers in the field of cancer epidemiology.

• Berge, Leon Alexander; Kulle, Bettina; Stenehjem, Jo S.; Heir, Trond; Karlstad, Øystein & Juzeniene, Asta [Vis alle 11 forfattere av denne artikkelen] (2020). Use of immunomodulating drugs and risk of cutaneous melanoma: A nationwide nested case-control study. Clinical Epidemiology. ISSN 1179-1349. 12, s. 1389–1401. doi: 10.2147/CLEP.S269446. Fulltekst i vitenarkiv
• Berge, Leon Alexander; Kulle, Bettina; Stenehjem, Jo S.; Heir, Trond; Furu, Kari & Juzeniene, Asta [Vis alle 11 forfattere av denne artikkelen] (2020). Use of Antidepressants and Risk of Cutaneous Melanoma: A Prospective Registry-Based Case-Control Study. Clinical Epidemiology. ISSN 1179-1349. 12, s. 193–202. doi: 10.2147/CLEP.S241249. Fulltekst i vitenarkiv
• Berge, Leon Alexander; Kulle, Bettina; Stenehjem, Jo S.; Larsen, Inger Kristin; Furu, Kari & Juzeniene, Asta [Vis alle 11 forfattere av denne artikkelen] (2019). Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: A protocol for a prospective case-control study. BMJ Open. ISSN 2044-6055. 9:e025246(2), s. 1–8. doi: 10.1136/bmjopen-2018-025246. Fulltekst i vitenarkiv

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• Liu, Fei-Chih; Veierød, Marit Bragelien; Kjærheim, Kristina; Robsahm, Trude Eid; Ghiasvand, Reza & Babigumira, Ronnie [Vis alle 11 forfattere av denne artikkelen] (2021). Excess risk of male breast cancer in the Norwegian Offshore Petroleum Workers (NOPW) cohort: a possible link to extreme night shift work? Breast Cancer Research. ISSN 1465-5411. doi: 10.1186/s13058-021-01485-w.
• Robsahm, Trude Eid; Stenehjem, Jo S.; Berge, Leon Alexander & Veierød, Marit Bragelien (2020). Prevalence of Indoor Tanning Among Teenagers in Norway Before and After Enforcement of Ban for Ages Under 18 Years. Acta Dermato-Venereologica. ISSN 0001-5555. 100(8). doi: 10.2340/00015555-3482.

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