Torunn Melnes

Stipendiat - Kosthold og aterosklerose

English version of this page

E-post torunn.melnes@medisin.uio.no

Brukernavn

Besøksadresse Sognsvannsveien 9 Domus Medica 0372 Oslo

Postadresse Postboks 1046 Blindern 0317 Oslo

Andre tilknytninger Det medisinske fakultet (Student)

Last ned visittkort

Faglige interesser

Klinisk ernæring
Kommunikasjon
Hjerte- og karsykdom
Familiær hyperkolesterolemi
Lipidmetabolisme, metabolomikk og genuttrykk
Folkehelse

Bakgrunn og utdanning

2020-d.d: Stipendiat, Avdeling for ernæringsvitenskap, Universitetet i Oslo
2019-2020: Klinisk ernæringsfysiolog, Molde sjukehus
2018: Klinisk ernæringsfysiolog, Stavanger universitetssjukehus
2018: Lærer i realfag, videregående skole
2013-2018: MSc i Klinisk ernæring, Universitetet i Oslo
2017: Forskningsassistent, Oslo universitetssykehus
2012-2016: Avdelingsingeniør, Folkehelseinstituttet
2012: Halvtårsstudium i Interkulturell kommunikasjon, Mediehøgskolen Gimlekollen

Annen erfaring:
Sensor i emnet "Idrett og Ernæring" ved Høgskulen i Volda.
Foredragsholder/underviser for masterstudenter i "Avansert Klinisk Sykepleie" ved Høgskolen i Molde og for elever ved Stavern folkehøgskole.
Arrangementkomité for NutriNOR PhD-konferanse 2023.

Priser

Best Poster Award, NuGO week 2023, Senigallia, Italia
Best Poster Award, Throne Holst Symposium 2022, Oslo

Emneord: Ernæring, Kolesterol, Hjerte- og karsykdom, Lipid metabolism, Metabolomikk, Kommunikasjon

Melnes, Torunn; Bogsrud, Martin Prøven; Christensen, Jacob Juel; Rundblad, Amanda; Narverud, Ingunn & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2024). Gene expression profiling in elderly patients with familial hypercholesterolemia with and without coronary heart disease. Atherosclerosis. ISSN 0021-9150. 392. doi: 10.1016/j.atherosclerosis.2024.117507.
Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2022). What characterizes event-free elderly FH patients? A comprehensive lipoprotein profiling. NMCD. Nutrition Metabolism and Cardiovascular Diseases. ISSN 0939-4753. 32(7), s. 1651–1660. doi: 10.1016/j.numecd.2022.03.028. Fulltekst i vitenarkiv Vis sammendrag
Familial hypercholesterolemia (FH) is a genetic disorder characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) and increased risk of pre- mature coronary heart disease (CHD). Cholesterol-lowering therapy (statins) reduces CHD risk, but have been available only in the last 25 years, thus, elderly FH patients have been exposed to elevated LDL-C levels most of their life. Surprisingly, some of these have never experienced any CHD event, raising the question whether they present CHD resistant characteristics. Identifying possible cardioprotective biomarkers could contribute to future CHD preventive treatment, therefore, we aimed to identify metabolic markers in event-free elderly FH subjects. Methods and results: We used a high-throughput nuclear magnetic resonance (NMR) spectroscopy platform to quantify a large number of metabolites in serum samples from 83 FH patients >65 years, and analyze differences between subjects with (n = 39) and without (n = 44) CHD. Mean age was 70 years in both groups (57% and 38% female in the event-free group and CHD group, respectively). The event-free group had significantly higher levels of large and extra-large high-density lipoprotein (HDL) particles, and higher concentration of Apolipoprotein A1 (ApoA1) and cholesterol in HDL and HDL2 particles, compared to the CHD group (p < 0.05 for all). Conclusion: CHD resistant elderly FH patients have higher levels of large HDL particles. The mechanisms behind the event-free survival among these patients remain unclear; hence, a deeper understanding of the metabolic profile in event-free elderly FH subjects may lead to development of novel preventive therapies.

Se alle arbeider i Cristin

Melnes, Torunn; Bogsrud, Martin Prøven; Christensen, Jacob J.; Rundblad, Amanda; Narverud, Ingunn & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2023). Difference in PBMC gene expression between elderly event-free FH patients and FH patients with CHD.
Melnes, Torunn; Bogsrud, Martin Prøven; Christensen, Jacob J.; Rundblad, Amanda; Narverud, Ingunn & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2023). Difference in PBMC gene expression between elderly event-free FH patients and FH patients with CHD.
Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2023). What characterizes event-free elderly FH patients? A comprehensive lipoprotein profiling.
Melnes, Torunn; Bogsrud, Martin Prøven; Christensen, Jacob J.; Rundblad, Amanda; Narverud, Ingunn & Retterstøl, Kjetil [Vis alle 10 forfattere av denne artikkelen] (2023). Difference in PBMC gene expression between elderly event-free FH patients and FH patients with CHD.
Rundblad, Amanda; Hansen, Anna Lena; Christensen, Jacob Juel; Melnes, Torunn; Ottestad, Inger Olaug & Narverud, Ingunn [Vis alle 12 forfattere av denne artikkelen] (2023). Patients with familial hypercholesterolemia have shorter telomeres than controls in older, but not in young subjects: a cross-sectional study.
Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2022). What characterizes event-free elderly FH patients? A comprehensive lipoprotein profiling.
Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2021). Event-free FH patients >65 years of age are characterized by higher concentration of large HDL particles.
Melnes, Torunn; Bogsrud, Martin Prøven; Thorsen, Ida; Fossum, Julie; Christensen, Jacob J. & Narverud, Ingunn [Vis alle 9 forfattere av denne artikkelen] (2021). Event-free FH patients ≥65 years of age are characterized by higher concentration of large HDL particles.