Arnt Eltvedt Fiane

• Aslam, Tayyba Naz; Barratt-Due, Andreas; Fiane, Arnt Eltvedt; Friis, Camilla Margrethe; Hofsø, Kristin & Kåsine, Trine [Show all 8 contributors for this article] (2024). Gravide med akutt, alvorlig respirasjonssvikt utl⊘st av covid-19. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 144(1), p. 1–8. doi: 10.4045/tidsskr.23.0615.
• Christensen, Anders Haugom; Wyller, Vegard Bruun Bratholm; Nygaard, Sissel; Rolid, Katrine; Nytrøen, Kari & Gullestad, Lars [Show all 10 contributors for this article] (2023). Factors Associated with Sinoatrial Reinnervation after Heart Transplantation. Transplantation direct. ISSN 2373-8731. 9(12). doi: 10.1097/TXD.0000000000001553. Full text in Research Archive
• Leuckfeld, Inga; Holm, Are Martin; Nilsen-Hoel, Tom & Fiane, Arnt Eltvedt (2023). Lungetransplantasjon i Norge 1999–2020. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(14). doi: 10.4045/tidsskr.22.0775. Full text in Research Archive
• Dellgren, Göran; Lund, Thomas Kromann; Raivio, Peter; Leuckfeld, Inga; Svahn, Johan & Holmberg, Erik C [Show all 12 contributors for this article] (2023). Effect of once-per-day tacrolimus versus twice-per-day ciclosporin on 3-year incidence of chronic lung allograft dysfunction after lung transplantation in Scandinavia (ScanCLAD): a multicentre randomised controlled trial. The Lancet Respiratory Medicine. ISSN 2213-2600. 12, p. 34–44. doi: 10.1016/S2213-2600(23)00293-X.
• Vistnes, Maria; Murugan Erusappan, Pugazendhi; Sasi, Athiramol; Nordén, Einar Sjaastad; Bergo, Kaja Knudsen & Romaine, Andreas [Show all 22 contributors for this article] (2023). Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction. Cardiovascular Research (CVR). ISSN 0008-6363. 119(10), p. 1915–1927. doi: 10.1093/cvr/cvad078. Full text in Research Archive
• Lilja, Didrik; Schalit, Itai; Espinoza, Andreas; Fiane, Arnt Eltvedt; Dahle, Gry & Sandbu, Helen Littorin [Show all 11 contributors for this article] (2023). Detection of inflow obstruction in left ventricular assist devices by accelerometer: A porcine model study. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 42(8), p. 1005–1014. doi: 10.1016/j.healun.2023.03.017. Full text in Research Archive
• Bakkehaug, Jens Petter; Kåsine, Trine; Romundstad, Luis Georg; Narum, Jon; Laake, Jon Henrik & Svalebjørg, Morten [Show all 12 contributors for this article] (2023). Ekstrakorporal membranoksygenering ved akutt lungesviktsyndrom hos covid-19-pasienter. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(2). doi: 10.4045/tidsskr.22.0545.
• Angleitner, Philipp; Kaider, Alexandra; De By, Theo M M H; Dimitrov, Kamen; Schlöglhofer, Thomas & Tops, Laurens F. [Show all 10 contributors for this article] (2022). Obesity and outcomes after left ventricular assist device implantation: insights from the EUROMACS Registry. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 62(3). doi: 10.1093/ejcts/ezac401.
• Schalit, Itai; Espinoza, Andreas Westenvik; Pettersen, Fred-Johan; Skulstad, Helge; Fosse, Erik & Fiane, Arnt Eltvedt [Show all 7 contributors for this article] (2022). Improved Detection of Thromboembolic Complications in Left Ventricular Assist Device by Novel Accelerometer-Based Analysis. ASAIO journal (1992). ISSN 1058-2916. 68(9), p. 1117–1125. doi: 10.1097/MAT.0000000000001654.
• Nygaard, Sissel; Christensen, Anders Haugom; Sletner, Line; Rolid, Katrine; Nytrøen, Kari & Gullestad, Lars [Show all 11 contributors for this article] (2022). Predictors of Hypertension Development 1 Year after Heart Transplantation. Transplantation. ISSN 0041-1337. 106(8), p. 1656–1665. doi: 10.1097/TP.0000000000004068.
• Merkle-Storms, Julia; Djordjevic, Ilija; Sabashnikov, Anton; Eghbalzadeh, Kaveh; Gkouziouta, Aggeliki & Fiane, Arnt Eltvedt [Show all 15 contributors for this article] (2022). Comparative analysis of LVAD patients in regard of ischaemic or idiopathic cardiomyopathy: A propensity-score analysis of EUROMACS data. International Journal of Artificial Organs. ISSN 0391-3988. 45(3), p. 284–291. doi: 10.1177/03913988221075045.
• Wisløff-Aase, Kristin; Skulstad, Helge; Beitnes, Jan Otto; Lundblad, Runar; Halvorsen, Per Steinar & Fiane, Arnt Eltvedt [Show all 7 contributors for this article] (2022). Left Ventricular Function Changes Induced by Moderate Hypothermia Are Rapidly Reversed after Rewarming - A Clinical Study. Critical Care Medicine. ISSN 0090-3493. 50(1), p. E52–E60. doi: 10.1097/CCM.0000000000005170.
• Christensen, Anders Haugom; Nygaard, Sissel; Rolid, Katrine; Nytrøen, Kari; Gullestad, Lars & Fiane, Arnt Eltvedt [Show all 10 contributors for this article] (2021). Strong evidence for parasympathetic sinoatrial reinnervation after heart transplantation. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. p. 1–12. doi: 10.1016/j.healun.2021.11.005. Full text in Research Archive
• Christensen, Anders Haugom; Nygaard, Sissel Irene; Rolid, Katrine; Nytrøen, Kari; Gullestad, Lars & Fiane, Arnt [Show all 10 contributors for this article] (2021). Early Signs of Sinoatrial Reinnervation in the Transplanted Heart. Transplantation. ISSN 0041-1337. 105(9), p. 2086–2096. doi: 10.1097/TP.0000000000003580.
• Gude, Einar & Fiane, Arnt E (2021). Can mechanical circulatory support be an effective treatment for HFpEF patients? Heart Failure Reviews. ISSN 1382-4147. doi: 10.1007/s10741-021-10154-1. Full text in Research Archive
• Suther, Lene Kathrine R; de Lange, Charlotte; Brun, Henrik; Svendsmark, Rolf Georg; Nguyen, Bac & Larsen, Stig [Show all 10 contributors for this article] (2021). 3.0T MR coronary angiography after arterial switch operation for transposition of the great arteries—Gd-FLASH versus non-enhanced SSFP. A feasibility study. Congenital Heart Disease. ISSN 1747-079X. 16(2), p. 107–121. doi: 10.32604/CHD.2021.014164. Full text in Research Archive
• Kvaslerud, Anette Borger; Hussain, Amjad Iqbal; Auensen, Andreas; Fiane, Arnt E; Skulstad, Helge & Aaberge, Lars [Show all 8 contributors for this article] (2021). Outcomes in asymptomatic, severe aortic stenosis. PLOS ONE. ISSN 1932-6203. doi: 10.1371/journal.pone.0249610. Full text in Research Archive
• Wyller, Vegard Bruun Bratholm; Nygaard, Sissel; Christensen, Anders Haugom; Rolid, Katrine; Nytrøen, Kari & Gullestad, Lars [Show all 10 contributors for this article] (2021). Functional evidence of low-pressure cardiopulmonary baroreceptor reinnervation 1 year after heart transplantation. European Journal of Applied Physiology. ISSN 1439-6319. 121(3), p. 915–927. doi: 10.1007/s00421-020-04586-0. Full text in Research Archive
• Alm-Kruse, Kristin; Sørensen, Gro; Osbakk, Svein Are; Sunde, Kjetil; Bendz, Bjørn & Andersen, Geir Øystein [Show all 9 contributors for this article] (2021). Outcome in refractory out-of-hospital cardiac arrest before and after implementation of an ECPR protocol. Resuscitation. ISSN 0300-9572. doi: 10.1016/j.resuscitation.2021.01.038. Full text in Research Archive
• Bjørnstad, Johannes Lagethon; Helgeland, Erik; Geiran, Odd & Fiane, Arnt Eltvedt (2020). Er EXCEL studien relevant for norske forhold? . Hjerteforum. ISSN 0802-1465. 33(3), p. 22–28.
• Marasco, Silvana; Simon, André R.; Tsui, Steven; Schramm, René; Eifert, Sandra & Hagl, Christian M. [Show all 15 contributors for this article] (2020). International experience using a durable, centrifugal-flow ventricular assist device for biventricular support. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 39(12), p. 1372–1379. doi: 10.1016/j.healun.2020.08.006.
• Zimpfer, Daniel; Fiane, Arnt E; Larbalestier, Robert; Tsui, Steven; Jansz, Paul & Simon, Andre [Show all 9 contributors for this article] (2020). Long-term survival of patients with advanced heart failure receiving an left ventricular assist device intended as a bridge to transplantation: The registry to evaluate the heartware left ventricular assist system. Circulation: Heart Failure. ISSN 1941-3289. 13:e006252, p. 1–6. doi: 10.1161/CIRCHEARTFAILURE.119.006252.
• Watne, Torstein; Chellappa, Stalin ; Leuckfeld, Inga; Fiane, Arnt E & Holm, Are Martin (2020). Flow-Cytometric Assessment of T Cell Response to Monitor Immunosuppression. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 39(4), p. S472–S473. doi: 10.1016/j.healun.2020.01.013.
• Olsen, Jul Eirik; Auråen, Henrik; Durheim, Michael; Fiane, Arnt E & Holm, Are Martin (2020). Predictors of long intensive care need after lung transplantation. Clinical Transplantation. ISSN 0902-0063. doi: 10.1111/ctr.14152.
• Lindberg, Beate; Videm, Vibeke; Dahl, Thorleif; Sørensen, Gro; Fiane, Arnt E & Thiara, Amrit Paul Singh (2020). Influence of the ECMO circuit on the concentration of nutritional supplements. Scientific Reports. ISSN 2045-2322. 10:19275, p. 1–10. doi: 10.1038/s41598-020-76299-5. Full text in Research Archive
• Schalit, Itai; Espinoza, Andreas Westenvik; Pettersen, Fred-Johan; Snartland, Steinar; Ringdal, Mari-Anne I Lindstein & Nilsen-Hoel, Tom [Show all 10 contributors for this article] (2020). Detection of thromboembolic events and pump thrombosis in heartware HVAD using accelerometer in a porcine model. ASAIO journal (1992). ISSN 1058-2916. p. 38–48. doi: 10.1097/MAT.0000000000000954.
• Nygaard, Sissel Irene; Christensen, Anders Haugom; Rolid, Katrine; Nytrøen, Kari; Gullestad, Lars & Fiane, Arnt E [Show all 11 contributors for this article] (2019). Autonomic cardiovascular control changes in recent heart transplant recipients lead to physiological limitations in response to orthostatic challenge and isometric exercise. European Journal of Applied Physiology. ISSN 1439-6319. 119(10), p. 2225–2236. doi: 10.1007/s00421-019-04207-5. Full text in Research Archive
• Hagness, Morten; Foss, Stein; SØRENSEN, DAG WENDELBO; Syversen, Torgunn Bø; Bakkan, Per Arne & Dahl, Thorleif [Show all 8 contributors for this article] (2019). Liver Transplant After Normothermic Regional Perfusion From Controlled Donors After Circulatory Death: The Norwegian Experience. Transplantation Proceedings. ISSN 0041-1345. 51(2), p. 475–478. doi: 10.1016/j.transproceed.2019.01.066. Full text in Research Archive
• Braun, Oscar Ö.; Nilsson, Johan; Gustafsson, Finn; Dellgren, Göran; Fiane, Arnt E & Lemstrom, Karl [Show all 9 contributors for this article] (2019). Continuous-flow LVADs in the Nordic countries: complications and mortality and its predictors. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 53(1), p. 14–20. doi: 10.1080/14017431.2019.1583365.
• Bürker, Britta Susanne; Gullestad, Lars; Gude, Einar; Havik, Odd E.; Relbo, Anne & Grov, Ingelin [Show all 12 contributors for this article] (2019). The predictive value of depression in the years after heart transplantation for mortality during long-term follow-up. Psychosomatic Medicine. ISSN 0033-3174. 81(6), p. 513–520. doi: 10.1097/PSY.0000000000000702. Full text in Research Archive
• Auråen, Henrik; Durheim, Michael; Dellgren, Gøran; Hämmäinen, Pekka; Larsson, H & Geiran, Odd [Show all 11 contributors for this article] (2019). Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis: A Nordic Multicenter Study. Transplantation. ISSN 0041-1337. 103(4), p. 807–814. doi: 10.1097/TP.0000000000002402. Full text in Research Archive
• Suther, Lene Kathrine R; Hopp, Einar; Geier, Oliver; Brun, Henrik; Nguyen, Bac & Tomterstad, Anders [Show all 10 contributors for this article] (2019). Diffuse myocardial fibrosis in adolescents operated with arterial switch for transposition of the great arteries - A CMR study. International Journal of Cardiology. ISSN 0167-5273. 276, p. 100–106. doi: 10.1016/j.ijcard.2018.11.107. Full text in Research Archive
• Schalit, Itai; Espinoza, Andreas Westenvik; Pettersen, Fred-Johan; Thiara, Amrit Paul Singh; Karlsen, Hilde & Sørensen, Gro [Show all 9 contributors for this article] (2018). Accelerometer Detects Pump Thrombosis and Thromboembolic Events in an In vitro HVAD Circuit. ASAIO journal (1992). ISSN 1058-2916. 64(5), p. 601–609. doi: 10.1097/MAT.0000000000000699.
• Hiis, Halvard Gautefall; Cosson, Marie-Victoire; Dahl, Christen Peder; Fiane, Arnt E; Levy, Finn Olav & Andersen, Geir Øystein [Show all 7 contributors for this article] (2018). Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 315(5), p. H1137–H1147. doi: 10.1152/ajpheart.00208.2018. Full text in Research Archive
• Auråen, Henrik; Schultz, Hans Henrik Lawaetz; Hämmäinen, Pekka; Riise, Gerdt C.; Larsson, Hillevi & Hansson, Lennart [Show all 12 contributors for this article] (2018). Urgent lung allocation system in the Scandiatransplant countries. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. p. 1–7. doi: 10.1016/j.healun.2018.08.002. Full text in Research Archive
• Dumont, Karl-Andreas; Kvitting, John Peder Escobar; Karlsen, Jørn S.; Remme, Espen W.; Hausken, John & Lundblad, Runar [Show all 8 contributors for this article] (2018). Validation of a holographic display for quantification of mitral annular dynamics by three-dimensional echocardiography. Journal of the American Society of Echocardiography. ISSN 0894-7317. p. 1–18. doi: 10.1016/j.echo.2018.08.010.
• Husebråten, Inger; Fiane, Arnt E; Ringdal, Mari-Anne I Lindstein & Thiara, Amrit Paul Singh (2018). Measurement of gaseous microemboli in the prime before the initiation of cardiopulmonary bypass. Perfusion. ISSN 0267-6591. 33(1), p. 30–35. doi: 10.1177/0267659117723454.
• Suther, Lene Kathrine R; Hopp, Einar; Smevik, Bjarne; Fiane, Arnt E; Lindberg, Harald L & Larsen, Stig [Show all 7 contributors for this article] (2018). Can visual analogue scale be used in radiologic subjective image quality assessment? Pediatric Radiology. ISSN 0301-0449. 48, p. 1567–1575. doi: 10.1007/s00247-018-4187-8. Full text in Research Archive
• Foss, Stein; Nordheim, Espen; SØRENSEN, DAG WENDELBO; Syversen, Torgunn Bø; Midtvedt, Karsten & Åsberg, Anders [Show all 12 contributors for this article] (2018). First Scandinavian Protocol for Controlled Donation After Circulatory Death Using Normothermic Regional Perfusion. Transplantation direct. ISSN 2373-8731. 4(7). doi: 10.1097/TXD.0000000000000802. Full text in Research Archive
• Parikh, Shan S.; Blackwell, Daniel J.; Gomez-Hurtado, Nieves; Frisk, Michael; Wang, Lili & Kim, Kyungsoo [Show all 12 contributors for this article] (2017). Thyroid and glucocorticoid hormones promote functional t-tubule Development in human-induced pluripotent stem cell-derived cardiomyocytes. Circulation Research. ISSN 0009-7330. 121(12), p. 1323–1330. doi: 10.1161/CIRCRESAHA.117.311920.
• Hussain, Amjad Iqbal; Auensen, Andreas; Brunborg, Cathrine; Aakhus, Svend; Fiane, Arnt E & Pettersen, Kjell [Show all 7 contributors for this article] (2017). Determinants and Outcome of Decision Making Among Patients with Severe Aortic Stenosis . Journal of Heart Valve Disease. ISSN 0966-8519. 26, p. 413–422.
• Rutkovskiy, Arkady; Sagave, Julia Fritzi; Czibik, Gabor Tamas; Baysa, Anton; Zihlavnikova, Katarina & Hillestad, Vigdis [Show all 14 contributors for this article] (2017). Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 77(5), p. 321–331. doi: 10.1080/00365513.2017.1318447.
• Rutkovskiy, Arkady; Malashicheva, Anna; Sullivan, Gareth; Bogdanova, Mariia; Kostareva, Anna & Stensløkken, Kåre-Olav [Show all 8 contributors for this article] (2017). Valve interstitial cells: The key to understanding the pathophysiology of heart valve calcification. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 6(9), p. 1–24. doi: 10.1161/JAHA.117.006339.
• Bürker, Britta Susanne; Gude, Einar; Gullestad, Lars; Grov, Ingelin; Relbo, Anne & Andreassen, Arne K. [Show all 12 contributors for this article] (2017). Cognitive function among long-term survivors of heart transplantation. Clinical Transplantation. ISSN 0902-0063. 31(12), p. 1–8. doi: 10.1111/ctr.13143.
• Bürker, Britta Susanne; Gullestad, Lars; Gude, Einar; Relbo, Anne; Grov, Ingelin & Hol, Per Kristian [Show all 13 contributors for this article] (2017). Cognitive function after heart transplantation: Comparing everolimus-based and calcineurin inhibitor-based regimens. Clinical Transplantation. ISSN 0902-0063. 31(4). doi: 10.1111/ctr.12927.
• Dahle, Gry; Rein, Kjell Arne & Fiane, Arnt E (2017). Single centre experience with transapical transcatheter mitral valve implantation. Interactive Cardiovascular and Thoracic Surgery. ISSN 1569-9293. 25(2), p. 177–184. doi: 10.1093/icvts/ivx038.
• Abraityte, Judita Aurelija; Lunde, Ida Gjervold; Askevold, Erik Tandberg; Michelsen, Annika; Christensen, Geir Arve & Aukrust, Pål [Show all 14 contributors for this article] (2017). Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-03625-9. Full text in Research Archive
• Grymyr, Ole-Johannes; Beitnes, Jan Otto; Eidet, Jo; Tølløfsrud, Stein G.; Fiane, Arnt E & Skulstad, Helge [Show all 8 contributors for this article] (2017). Detection of intraoperative myocardial dysfunction by accelerometer during aortic valve replacement. Interactive Cardiovascular and Thoracic Surgery. ISSN 1569-9293. 24(2), p. 188–195. doi: 10.1093/icvts/ivw326.
• Abraityte, Judita Aurelija; Vinge, Leif Erik; Askevold, Erik Tandberg; Lekva, Tove; Michelsen, Annika & Ranheim, Trine [Show all 16 contributors for this article] (2017). Wnt5a is elevated in heart failure and affects cardiac fibroblast function. Journal of Molecular Medicine. ISSN 0946-2716. 95(7), p. 767–777. doi: 10.1007/s00109-017-1529-1.
• Norum, Hilde Margrethe; Broch, Kaspar; Michelsen, Annika; Lunde, Ida Gjervold; Lekva, Tove & Abraityte, Judita Aurelija [Show all 14 contributors for this article] (2017). The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy. Journal of Cardiovascular Translational Research (JCTR). ISSN 1937-5387. p. 1–10. doi: 10.1007/s12265-017-9748-y.
• Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine & Palibrk, Vuk [Show all 29 contributors for this article] (2017). NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports. ISSN 2211-1247. 18, p. 82–92. doi: 10.1016/j.celrep.2016.12.009. Full text in Research Archive
• Mishra, Vinod Kumar; Fiane, Arnt E; Winsnes, Benny Adam; Geiran, Odd; Sørensen, Gro & Hagen, Terje P. [Show all 7 contributors for this article] (2017). Cardiac Replacement Therapies: Outcomes and Costs for Heart Transplantation versus Circulatory Assist. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 51(1), p. 1–7. doi: 10.1080/14017431.2016.1196826.
• Zimpfer, D; Strueber, M.; Aigner, P; Schmitto, JD; Fiane, Arnt E & Larbalestier, Robert [Show all 12 contributors for this article] (2016). Evaluation of the HeartWare ventricular assist device Lavare cycle in a particle image velocimetry model and in clinical practice. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. p. 839–848. doi: 10.1093/ejcts/ezw232.
• Schmitto, JD; Zimpfer, D; Fiane, Arnt E; Larbalestier, Robert; Tsui, Steven & Jansz, P [Show all 9 contributors for this article] (2016). Long-term support of patients receiving a left ventricular assist device for advanced heart failure: a follow-up analysis of the Registry to Evaluate the HeartWare Left Ventricular Assist System. Journal of Cardiothoracic Surgery. ISSN 1749-8090. p. 834–838. doi: 10.1093/ejcts/ezw224.
• Nygaard, Kent Inge; Thiara, Amrit Paul Singh; Tronstad, Christian; Ringdal, Mari-Anne I Lindstein & Fiane, Arnt E (2016). VAVD vacuum may cause bubble transgression in membrane oxygenators. Perfusion. ISSN 0267-6591. 31(8), p. 648–652. doi: 10.1177/0267659116651345.
• Melleby, Arne Olav; Strand, Mari Elen; Romaine, Andreas; Herum, Kate Louise Møller; Skrbic, Biljana & Dahl, Christen Peder [Show all 11 contributors for this article] (2016). The heparan sulfate proteoglycan glypican-6 is upregulated in the failing heart, and regulates cardiomyocyte growth through ERK1/2 Signaling. PLOS ONE. ISSN 1932-6203. 11(10). doi: 10.1371/journal.pone.0165079.
• Dhondup, Yangchen; Ueland, Thor; Dahl, Christen Peder; Askevold, Erik Tandberg; Sandanger, Øystein & Fiane, Arnt E [Show all 14 contributors for this article] (2016). Low circulating levels of mitochondrial and high levels of nuclear DNA predict mortality in chronic heart failure. Journal of Cardiac Failure. ISSN 1071-9164. 22(10), p. 823–828. doi: 10.1016/j.cardfail.2016.06.013. Show summary

  Background Mitochondrial DNA (mtDNA) and possibly nuclear DNA (nDNA) are released as danger-associated molecular patterns during cardiac stress, and may activate several innate immune receptors. The purpose of this study was to investigate the regulation of these danger-associated molecular patterns during human heart failure (HF). Methods and Results Plasma levels of mtDNA and nDNA from HF patients (n = 84) were analyzed by reverse transcriptase-polymerase chain reaction and compared with controls (n = 72). Increased levels of mtDNA were found in New York Heart Association (NYHA) I-II and NYHA III-IV. There was evidence of increased nDNA in NYHA III-IV compared with controls and NYHA I-II. Kaplan-Meier analysis revealed higher mortality in patients with high nDNA levels, whereas high levels of mtDNA were associated with survival. Conclusions Plasma levels of mtDNA and nDNA are elevated in human HF associated with increased and decreased mortality, respectively. This study may suggest a rationale for exploring interventions within inflammatory signaling pathways activated by nucleic acids as novel targets in treatment of HF.

• Rashidi, Mira; Esmaily, Sorosh; Fiane, Arnt E; Gude, Einar; Tønseth, Kim Aleksander & Ueland, Thor [Show all 10 contributors for this article] (2016). Wound complications and surgical events in de novo heart transplant patients treated with everolimus: Post-hoc analysis of the SCHEDULE trial. International Journal of Cardiology. ISSN 0167-5273. 210, p. 80–84. doi: 10.1016/j.ijcard.2016.02.075.
• Broch, Kaspar; Murbræch, Klaus; Ragnarsson, Asgrimur; Gude, Einar; Andersen, Rune & Fiane, Arnt E [Show all 9 contributors for this article] (2016). Echocardiographic evidence of right ventricular functional improvement after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 35(1), p. 80–86. doi: 10.1016/j.healun.2015.08.007.
• Dumont, Karl-Andreas; Karlsen, Jørn Skaarud; Helle-Valle, Thomas Michael; Fiane, Arnt E; Lundblad, Runar & Urheim, Stig (2015). Mitral valve analysis adding a virtual semi-transparent annulus plane for detection of prolapsing segments. Cardiovascular Ultrasound. ISSN 1476-7120. 13:25, p. 1–9. doi: 10.1186/s12947-015-0019-2.
• Lindstedt, Sandra; Dellgren, Göran; Iversen, Martin; Riise, Gerdt C.; Bjørtuft, Øystein & Hämmäinen, Pekka [Show all 9 contributors for this article] (2015). Pulmonary retransplantation in the nordic countries. Annals of Thoracic Surgery. ISSN 0003-4975. 99(5), p. 1781–1787. doi: 10.1016/j.athoracsur.2015.01.052.
• Hein, E; Munthe-Fog, Lea; Thiara, Amrit Paul Singh; Fiane, Arnt E; Mollnes, Tom Eirik & Garred, P (2015). Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo. Clinical and Experimental Immunology. ISSN 0009-9104. 179(2), p. 294–299. doi: 10.1111/cei.12446.
• Nytrøen, Kari; Rustad, Lene Anette; Gude, Einar; Hallén, Jostein; Fiane, Arnt E & Rolid, Katrine [Show all 9 contributors for this article] (2014). Muscular exercise capacity and body fat predict VO2peak in heart transplant recipients. European Journal of Preventive Cardiology (EJPC). ISSN 2047-4873. 21(1), p. 21–29. doi: 10.1177/2047487312450540.
• Strueber, M.; Larbalestier, Robert; Jansz, P; Zimpfer, D; Fiane, Arnt E & Tsui, Steven [Show all 12 contributors for this article] (2014). Results of the post-market Registry to Evaluate the HeartWare Left Ventricular Assist System (ReVOLVE). The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 33(5), p. 486–491. doi: 10.1016/j.healun.2014.01.856.
• Gude, Einar; Fiane, Arnt E & Sørensen, Gro (2014). LVAD som varig behandling - muligheter, begrensninger og status i Norge. Hjerteforum. ISSN 0802-1465. 27(3), p. 16–22.
• Finsen, Alexandra; Ueland, Thor; Sjaastad, Ivar; Ranheim, Trine; Ahmed, Muhammad Shakil & Dahl, Christen Peder [Show all 15 contributors for this article] (2014). The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling. PLOS ONE. ISSN 1932-6203. 9. doi: 10.1371/journal.pone.0112172.
• Rashidi, Mitra; Barstad, Marius; Brunborg, Cathrine & Fiane, Arnt E (2014). Bilateral pectoralis muscle advancement flap in the management of deep sternal wound infection: A single clinic study of clinical outcome and postoperative quality of life. European journal of plastic surgery. ISSN 0930-343X. 37(8), p. 423–430. doi: 10.1007/s00238-014-0967-z.
• Askevold, Erik Tandberg; Aukrust, Pål; Nymo, Ståle Haugset; Lunde, Ida Gjervold; Kaasbøll, Ole Jørgen & Aakhus, Svend [Show all 21 contributors for this article] (2014). The cardiokine secreted Frizzled related protein 3, a modulator of Wnt-signalling, in clinical and experimental heart failure. Journal of Internal Medicine. ISSN 0954-6820. 275(6), p. 621–630. doi: 10.1111/joim.12175.
• Auråen, Henrik; Mollnes, Tom Eirik; Bjørtuft, Øystein; Bakkan, Per Arne; Geiran, Odd & Kongerud, Johny [Show all 8 contributors for this article] (2013). Multiorgan procurement increases systemic inflammation in brain dead donors. Clinical Transplantation. ISSN 0902-0063. 27(4), p. 613–618. doi: 10.1111/ctr.12175.
• Dahle, Gry; Rein, Kjell Arne; Fiane, Arnt E; Fosse, Erik; Kushi, Ishtiaq & Hagen, Terje P. [Show all 7 contributors for this article] (2012). Innovative technology-transcatheter aortic valve implantation: Cost and reimbursement issues. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 46(6), p. 345–352. doi: 10.3109/14017431.2012.724177.
• Mishra, Vinod Kumar; Fiane, Arnt E; Geiran, Odd; Sørensen, Gro; Khushi, Ishtiaq & Hagen, Terje P. (2012). Hospital costs fell as numbers of LVADs were increasing: experiences from Oslo University Hospital. Journal of Cardiothoracic Surgery. ISSN 1749-8090. Aug(27). doi: 10.1186/1749-8090-7-76.
• Rashidi, Mitra; Nilsen-Hoel, Tom; Fiane, Arnt E & Lindberg, Harald L (2012). Combined Repair of Upper Sternal Cleft and Transposition of the Great Arteries in a Newborn. Annals of Thoracic Surgery. ISSN 0003-4975. 94(5), p. 1722–1724. doi: 10.1016/j.athoracsur.2012.02.097.
• Nytrøen, Kari; Rustad, Lene Anette; Aukrust, Pål; Ueland, Thor; Hallén, Jostein & Holm, Inger [Show all 12 contributors for this article] (2012). High-Intensity Interval Training Improves Peak Oxygen Uptake and Muscular Exercise Capacity in Heart Transplant Recipients. American Journal of Transplantation. ISSN 1600-6135. 12(11), p. 3134–3142. doi: 10.1111/j.1600-6143.2012.04221.x.
• Yndestad, Arne; Finsen, Alexandra; Ueland, Thor; Husberg, Cathrine; Dahl, Christen Peder & Øie, Erik [Show all 19 contributors for this article] (2012). The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure. PLOS ONE. ISSN 1932-6203. 7(3). doi: 10.1371/journal.pone.0033038.
• Timms, Daniel; Gude, Einar; Gaddum, Nicholas; Lim, Einly; Greatrex, Nicholas & Wong, Kai [Show all 10 contributors for this article] (2011). Assessment of Right Pump Outflow Banding and Speed Changes on Pulmonary Hemodynamics During Biventricular Support With Two Rotary Left Ventricular Assist Devices. Artificial Organs. ISSN 0160-564X. 35(8), p. 807–832 . doi: 10.1111/j.1525-1594.2011.01283.x.
• Epailly, E; Albanell, J.; Andreassen, Arne K.; Bara, C; Campistol, JM & Delgado, Jonathan Førland [Show all 15 contributors for this article] (2011). Proliferation signal inhibitors and post-transplant malignancies in heart transplantation: practical clinical management questions. Clinical Transplantation. ISSN 0902-0063. 25(5), p. E475–E486. doi: 10.1111/j.1399-0012.2011.01476.x.
• Thiara, Amrit Paul Singh; Mollnes, Tom Eirik; Videm, Vibeke; Andersen, Vidar Ytterdal; Svennevig, Katja Christiane & Kolset, Svein Olav [Show all 7 contributors for this article] (2011). Biocompatibility and pathways of initial complement pathway activation with Phisio- and PMEA-coated cardiopulmonary bypass circuits during open-heart surgery. Perfusion. ISSN 0267-6591. 26(2), p. 107–114. doi: 10.1177/0267659110392438.
• Eggum, Rune; Ueland, Thor; Mollnes, Tom Eirik; Videm, Vibeke; Fiane, Arnt E & Aukrust, Pål [Show all 7 contributors for this article] (2010). Perfusion temperature, thyroid horomones and inflammation during pediatric cardiac surgery. Interactive Cardiovascular and Thoracic Surgery. ISSN 1569-9293. 10, p. 76–80. doi: 10.1510/icvts.2009.213876.
• Gude, Einar; Andreassen, Arne K.; Arora, Satish; Gullestad, Lars; Grov, Ingelin & Hartmann, Anders [Show all 11 contributors for this article] (2010). Acute renal failure early after heart transplantation: risk factors and clinical consequences. Clinical Transplantation. ISSN 0902-0063. 24(6), p. E207–E213. doi: 10.1111/j.1399-0012.2010.01225.x.
• Mishra, Vinod Kumar; Geiran, Odd; Fiane, Arnt E; Sørensen, Gro; Andresen, Sølvi & Olsen, Ellen Kristin [Show all 8 contributors for this article] (2010). Costs and reimbursement gaps following implementation of 3rd generation Left Ventricular Assist Devices. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 29(1), p. 72–78. doi: 10.1016/j.healun.2009.06.029. Show summary

  BACKGROUND: The purpose of this study was to compare and contrast total hospital costs and subsequent reimbursement of implementing a new program using a third-generation left ventricular assist device (LVAD) in Norway. METHODS: Between July 2005 and March 2008, the total costs of treatment for 9 patients were examined. Costs were calculated for three periods—the pre-implantation LVAD phase, the LVAD implantation phase and the post-implantation LVAD phase—as well as for total hospital care. Patientspecific costs were obtained prospectively from patient records and included personnel resources, medication, blood products, blood chemistry and microbiology, imaging, and procedure costs including operating room costs. Overhead costs were registered retrospectively and allocated to the specific patient by pre-defined allocation keys. Finally, patient-specific costs and overhead costs were aggregated into total patient costs. RESULTS: The average total patient cost in 2007 U.S. dollars was $735,342 and the median was $613,087 (range $342,581 to $1,256,026). The mean length of stay was 77 days (range 40 to 127 days). For the LVAD implantation phase, the mean cost was $457,795 and median cost was $458,611 (range $246,239 to $677,680). The mean length of stay for the LVAD implantation phase was 55 days (range 25 to 125 days). The diagnosis-related group (DRG) reimbursement (2007) was $143,192. CONCLUSIONS: There is significant discrepancy between actual hospital costs and the current Norwegian DRG reimbursement for the LVAD procedure. This discrepancy can be partly explained by excessive costs related to the introduction of a new program with new technology. Costly innovations should be considered in price setting of reimbursement for novel technology.

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• Skauby, Morten Heier; Heldal, Kristian; Line, Pål Dag; SØRENSEN, DAG WENDELBO; Fiane, Arnt Eltvedt & Hagness, Morten (2023). Lengre ventelister for organtransplantasjon. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(9). doi: 10.4045/tidsskr.22.0777.
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• Halvorsen, Per Steinar; Espinoza, Andreas Westenvik; Fiane, Arnt E & Fosse, Erik (2013). Continuous Monitoring of Right Ventricular Function with a 3-Axis Accelerometer during Left Ventricular Assist Device Implantation. The Journal of Heart and Lung Transplantation. ISSN 1053-2498. 32(4), p. S161–S162.
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