Bjørn Bendz

• Holm, Marianne Sætrang; Fålun, Nina Britt; Bendz, Bjørn; Fridlund, Bengt Gotthard Anton; Langørgen, Jørund & Pettersen, Trond Røed [Show all 8 contributors for this article] (2023). The patient experience of in-hospital telemetry monitoring: a qualitative analysis. European Journal of Cardiovascular Nursing. ISSN 1474-5151. 23(3), p. 258–266. doi: 10.1093/eurjcn/zvad082. Full text in Research Archive
• Instenes, Irene; Breivik, Kyrre; Borregaard, Britt; Larsen, Alf Inge; Allore, Heather & Bendz, Bjørn [Show all 9 contributors for this article] (2023). Phenotyping Self-Reported Health Profiles in Octogenarians and Nonagenarians After Percutaneous Coronary Intervention: A Latent Profile Analysis. Heart, Lung and Circulation. ISSN 1443-9506. doi: 10.1016/j.hlc.2023.09.004. Show summary

  Background Little is known about self-reported health in octogenarians (≥80 years) and nonagenarians (≥90 years) following percutaneous coronary intervention (PCI), including characteristics of different health outcomes. This study aimed to phenotype latent health profiles of self-reported health in older adults 2 months post-PCI. Methods A prospective, multicentre, real-world study (CONCARDPCI) of 270 octogenarians and nonagenarians was performed with five validated and standardised measures of self-reported health at 2 months post-PCI. Latent profile analysis was used to identify health profiles, and multinomial logistic regression analyses were used to investigate the associations between patient characteristics and health profiles. Results Three latent health profiles were identified: The Poor health profile included 29%, the Moderate health profile included 39%, and the Good health profile included 32% of the participants. Older adults who were frail (OR 2.50, 95% CI 1.17–5.33), had a low exercise level (OR 0.49, 95% CI 0.39–0.95), and low alcohol intake (OR 0.61, 95% CI 0.39–0.95) were more likely to belong to the Poor health profile relative to the Good health profile. Furthermore, older age (OR 1.19, 95% CI 1.03–1.37) and lower exercise level (OR 0.64, 95% CI 0.43–0.97) were associated with belonging to the Moderate health profile relative to the Good health profile. Conclusion Two months after PCI, most participants displayed having Moderate to Good health profiles. Those with a Poor health profile were more likely to be frail and less active. These findings highlight that follow-up care has to be patient-centred and tailored to improve the health status of older adults.

• Berg, Erlend; Tegn, Nicolai Kloumann; Abdelnoor, Michael; Røysland, Kjetil; Ryalen, Pål Christie & Aaberge, Lars [Show all 14 contributors for this article] (2023). Long-Term Outcomes of Invasive vs Conservative Strategies for Older Patients With Non–ST-Segment Elevation Acute Coronary Syndromes. Journal of the American College of Cardiology. ISSN 0735-1097. 82(21), p. 2021–2030. doi: 10.1016/j.jacc.2023.09.809. Full text in Research Archive
• Dodgson, Christopher Alexander Steele; Beitnes, Jan Otto; Kløve, Sophie Foss; Herstad, Jon; Opdahl, Anders & Undseth, Ragnhild Marie [Show all 13 contributors for this article] (2023). An investigator-sponsored pragmatic randomized controlled trial of AntiCoagulation vs AcetylSalicylic Acid after Transcatheter Aortic Valve Implantation: Rationale and design of ACASA-TAVI. American Heart Journal. ISSN 0002-8703. 265, p. 225–232. doi: 10.1016/j.ahj.2023.08.010. Full text in Research Archive
• Rafique, Muzammil; Solberg, Ole Geir; Gullestad, Lars; Bendz, Bjørn; Murbræch, Klaus & Nytrøen, Kari [Show all 8 contributors for this article] (2023). Effects of high-intensity interval training on cardiac remodelling, function and coronary microcirculation in de novo heart transplant patients: a substudy of the HITTS randomised controlled trial. BMJ Open sport & exercise medicine. ISSN 2055-7647. 9(3). doi: 10.1136/bmjsem-2022-001331. Full text in Research Archive
• Woxholt, Sindre; Ueland, Thor; Aukrust, Pål; Anstensrud, Anne Kristine; Broch, Kaspar & Tøllefsen, Ingvild Maria [Show all 20 contributors for this article] (2023). Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab. Open heart. ISSN 2053-3624. 10(2), p. 1–8. doi: 10.1136/openhrt-2023-002301. Full text in Research Archive
• Okuno, Taishi; Dangas, George D.; Hengstenberg, Christian; Sartori, Samantha; Herrmann, Howard C. & de Winter, Robert [Show all 30 contributors for this article] (2022). Two-year clinical outcomes after successful transcatheter aortic valve implantation with balloon-expandable versus self-expanding valves: A subanalysis of the GALILEO trial. Catheterization and cardiovascular interventions. ISSN 1522-1946. 100(4), p. 636–645. doi: 10.1002/ccd.30370.
• Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar & Woxholt, Sindre [Show all 29 contributors for this article] (2022). Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial. EBioMedicine. ISSN 2352-3964. 80. doi: 10.1016/j.ebiom.2022.104013. Full text in Research Archive
• Pettersen, Trond Røed; Schjøtt, Jan Didrik; Allore, Heather G.; Bendz, Bjørn; Borregaard, Britt & Fridlund, Bengt Gotthard Anton [Show all 11 contributors for this article] (2022). Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study. BMJ Open. ISSN 2044-6055. 12(9). doi: 10.1136/bmjopen-2022-061689. Full text in Research Archive
• Nordeng, Jostein; Schandiz, Hossein Khalkhali; Solheim, Svein; Åkra, Sissel; Hoffmann, Pavel & Roald, Borghild [Show all 10 contributors for this article] (2022). TIMP-1 expression in coronary thrombi associate with myocardial injury in ST-elevation myocardial infarction patients. Coronary Artery Disease. ISSN 0954-6928. 33(6), p. 446–455. doi: 10.1097/MCA.0000000000001128. Full text in Research Archive
• Nordeng, Jostein; Solheim, Svein; Åkra, Sissel; Schandiz, Hossein Khalkhali; Hoffmann, Pavel & Roald, Borghild [Show all 10 contributors for this article] (2022). Gene expression of fibrinolytic markers in coronary thrombi. Thrombosis Journal. ISSN 1477-9560. 20. doi: 10.1186/s12959-022-00383-1. Full text in Research Archive
• Norum, Ingvild Billehaug; Otterstad, Jan Erik; Ruddox, Vidar; Bendz, Bjørn & Edvardsen, Thor (2022). Novel regional longitudinal strain by speckle tracking to detect significant coronary artery disease in patients admitted to the emergency department for chest pain suggestive of acute coronary syndrome. Journal of Echocardiography. ISSN 1349-0222. 20(3), p. 166–177. doi: 10.1007/s12574-022-00568-7. Full text in Research Archive Show summary

  Background Global longitudinal strain has shown variable results in detecting ischemia in patients admitted to the emergency department with chest pain, but without other clear evidence of coronary artery disease (CAD). Our aim was to investigate whether assessment of regional longitudinal myocardial function could assist in detecting significant CAD in these patients. Methods Clinical evaluation, electrocardiogram, echocardiogram and troponin T were evaluated in 126 patients admitted with chest pain. A subsequent invasive coronary angiography divided patients into two groups: significant CAD (CAD+) or non-significant CAD (CAD−). Global and regional myocardial function were evaluated by speckle tracking echocardiography. Regional longitudinal strain was defined as the highest longitudinal strain values in four adjacent left ventricular segments and termed 4AS. Results CAD+ was found in 37 patients (29%) of which 51% had elevated troponin. Mean 4AS was − 13.1% (± 3.5) in the CAD+ and − 15.2% (± 2.7) (p = 0.002) in the CAD− group. Predictors for CAD+ were age [OR 1.06 (1.01–1.11, p = 0.026)], smoking [OR 3.39 (1.21–9.51, p = 0.020)], troponin [OR 3.32 (1.28–8.60, p = 0.014)) and 4AS (OR 1.24 (1.05–1.46, p = 0.010)]. A cutoff for 4AS of > − 15% showed the best diagnostic performance with event-reclassification of 0.41 (p < 0.001), non-event-reclassification of − 0.34 (p < 0.001) and net reclassification improvement 0.07 (p = 0.60). Conclusion Decreased myocardial function in four adjacent LV segments assessed by strain has the potential to detect significant CAD in patients admitted with chest pain and negative/slightly elevated initial troponin.

• Rafique, Muzammil; Solberg, Ole Geir; Gullestad, Lars; Bendz, Bjørn; Holm, Niels Ramsing & Neghabat, Omeed [Show all 10 contributors for this article] (2021). A randomized clinical study using optical coherence tomography to evaluate the short-term effects of high-intensity interval training on cardiac allograft vasculopathy: a HITTS substudy. Clinical Transplantation. ISSN 0902-0063. 36:e14488, p. 1–10. doi: 10.1111/ctr.14488. Full text in Research Archive
• Helseth, Ragnhild; Kleveland, Ola; Ueland, Thor; Wiseth, Rune; Damås, Jan Kristian & Broch, Kaspar [Show all 11 contributors for this article] (2021). Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction. Open heart. ISSN 2053-3624. 8(1). doi: 10.1136/openhrt-2020-001492. Full text in Research Archive
• Broch, Kaspar; Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria & Bendz, Bjørn [Show all 23 contributors for this article] (2021). Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction. Journal of the American College of Cardiology. ISSN 0735-1097. 77(15), p. 1845–1855. doi: 10.1016/j.jacc.2021.02.049. Full text in Research Archive
• Otterstad, Jan Erik; Norum, Ingvild Billehaug; Ruddox, Vidar; Le, An Chau Maria; Bendz, Bjørn & Munkhaugen, John [Show all 8 contributors for this article] (2021). Prognostic impact of non-improvement of global longitudinal strain in patients with revascularized acute myocardial infarction. The International Journal of Cardiovascular Imaging. ISSN 1569-5794. 37, p. 3477–3487. doi: 10.1007/s10554-021-02349-2. Full text in Research Archive Show summary

  Global longitudinal strain (GLS) is a more sensitive prognostic factor than left ventricular ejection fraction (LVEF) in various cardiac diseases. Little is known about the clinical impact of GLS changes after acute myocardial infarction (AMI). The present study aimed to explore if non-improvement of GLS after 3 months was associated with higher risk of subsequent composite cardiovascular events (CCVE). Patients with AMI were consecutively included at a secondary care center in Norway between April 2016 and July 2018 within 4 days following percutaneous coronary intervention. Echocardiography was performed at baseline and after 3 months. Patients were categorized with non-improvement (0 to − 100%) or improvement (0 to 100%) in GLS relative to the baseline value. Among 214 patients with mean age 65 (± 10) years and mean LVEF 50% (± 8) at baseline, 50 (23%) had non-improvement (GLS: − 16.0% (± 3.7) to − 14.2% (± 3.6)) and 164 (77%) had improvement (GLS: − 14.0% (± 3.0) to − 16.9% (± 3.0%)). During a mean follow-up of 3.3 years (95% CI 3.2 to 3.4) 77 CCVE occurred in 52 patients. In adjusted Cox regression analyses, baseline GLS was associated with all recurrent CCVE (HR 1.1, 95% CI 1.0 to 1.2, p < 0.001) whereas non-improvement versus improvement over 3 months follow-up was not. Baseline GLS was significantly associated with the number of CCVE in revascularized AMI patients whereas non-improvement of GLS after 3 months was not. Further large-scale studies are needed before repeated GLS measurements may be recommended in clinical practice.

• Samuelsen, Per-Jostein; Eggen, Anne Elise; Steigen, Terje; Wilsgaard, Tom; Kristensen, Andreas & Skogsholm, Anne [Show all 12 contributors for this article] (2021). Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT). PLOS ONE. ISSN 1932-6203. 16(3). doi: 10.1371/journal.pone.0247358. Full text in Research Archive Show summary

  Introduction Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian Coronary Stent Trial (NORSTENT). Materials and methods NORSTENT was a randomized, double blind, pragmatic trial among patients with acute coronary syndrome or stable coronary disease undergoing PCI during 2008–11. The patients (N = 9,013) were randomized to receive either a drug-eluting stent or a bare-metal stent, and were treated with at least nine months of DAPT. The patients were followed for a median of five years, with Bleeding Academic Research Consortium (BARC) 3–5 major bleeding as one of the safety endpoints. We estimated cumulative incidence of major bleeding by a competing risks model and risk factors through cause-specific Cox models. Results The 12-month cumulative incidence of major bleeding was 2.3%. Independent risk factors for major bleeding were chronic kidney disease, low bodyweight (< 60 kilograms), diabetes mellitus, and advanced age (> 80 years). A myocardial infarction (MI) or PCI during follow-up increased the risk of major bleeding (HR = 1.67, 95% CI 1-29-2.15). Conclusions The 12-month cumulative incidence of major bleeding in NORSTENT was higher than reported in previous, explanatory trials. This analysis strengthens the role of chronic kidney disease, advanced age, and low bodyweight as risk factors for major bleeding among patients receiving DAPT after PCI. The presence of diabetes mellitus or recurrent MI among patients is furthermore a signal of increased bleeding risk. Clinical trial registration Unique identifier NCT00811772; http://www.clinicaltrial.gov.

• Nordeng, Jostein; Schandiz, Hossein Khalkhali; Solheim, Svein; Åkra, Sissel; Hoffmann, Pavel & Roald, Borghild [Show all 10 contributors for this article] (2021). The Inflammasome Signaling Pathway Is Actively Regulated and Related to Myocardial Damage in Coronary Thrombi from Patients with STEMI. Mediators of Inflammation. ISSN 0962-9351. 2021, p. 1–12. doi: 10.1155/2021/5525917. Full text in Research Archive
• Alm-Kruse, Kristin; Sørensen, Gro; Osbakk, Svein Are; Sunde, Kjetil; Bendz, Bjørn & Andersen, Geir Øystein [Show all 9 contributors for this article] (2021). Outcome in refractory out-of-hospital cardiac arrest before and after implementation of an ECPR protocol. Resuscitation. ISSN 0300-9572. doi: 10.1016/j.resuscitation.2021.01.038. Full text in Research Archive
• Tegn, Nicolai Kloumann; Eek, Christian; Abdelnoor, Michael; Aaberge, Lars; Endresen, Knut & Skårdal, Rita [Show all 9 contributors for this article] (2020). Patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris randomised to an invasive versus conservative strategy: angiographic and procedural results from the After Eighty study. Open heart. ISSN 2053-3624. doi: 10.1136/openhrt-2020-001256.
• Bjørnstad, Johannes; Khan, Adil Mahboob; Røed-Undlien, Henriette; Bendz, Bjørn; Nygård, Ståle & Nilsen-Hoel, Tom [Show all 7 contributors for this article] (2020). Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants. Open heart. ISSN 2053-3624. 7:e001278(2), p. 1–9. doi: 10.1136/openhrt-2020-001278. Full text in Research Archive
• Otterstad, Jan Erik; Norum, Ingvild Billehaug; Ruddox, Vidar; Bendz, Bjørn; Haugaa, Kristina & Edvardsen, Thor (2020). The impact of semi-automatic versus manually adjusted assessment of global longitudinal strain in post-myocardial infarction patients. The International Journal of Cardiovascular Imaging. ISSN 1569-5794. 36(7), p. 1283–1290. doi: 10.1007/s10554-020-01826-4. Full text in Research Archive Show summary

  There are unresolved questions related to the proper use of editing the region of interest (ROI) for measurements of global longitudinal strain (GLS). The purpose of the present study was to compare the semi-automatic default GLS value by the vendor's software with manually adjusted GLS and test the impact on GLS measures with different ROI widths. We selected 25 patients post myocardial infarction treated with PCI who had excellent echocardiographic recordings after 2-5 days and 3 months. The different GLS values were assessed from these 50 analyses in three steps. The semi-automatically GLS by default ROIs was compared with manually adjusted ROIs widths selected by an expert and then with manual adjustments, but with fixed ROIs being narrow, medium and wide. Their mean age was 64 (+/- 12) years, 52% had ST elevation MI and mean LVEF was 52 (+/- 4)%. Mean default GLS was - 15.3 (+/- 2.5)% with the widest ROI level selected semi-automatically in 78% of all widths. The mean expert GLS with manually adjusted ROI was - 14.7 (+/- 2.4)%, and the medium ROI level was selected by the expert in 85% of all examinations. The mean adjusted GLS, but with fixed ROIs widths was - 15.0 (+/- 2.5%)% with narrow ROI, - 14.7 (+/- 2.6)% with medium and - 13.5 (+/- 2.3)% with wide ROI width (p < 0.001 vs. default GLS). The Intra Class Coefficient Correlation between default and manually adjusted expert GLS was 0.93 (p < 0.001). The difference between the default and the manually adjusted expert GLS was neglectable. These findings may represent a simplification of the assessment of GLS that might increase its use in clinical practice. The GLS measurements with a fixed wide ROIs were significantly different from the expert measurements and indicate that a wide ROI should be avoided

• Norekvål, Tone Merete; Allore, Heather G; Bendz, Bjørn; Bjorvatn, Cathrine; Borregaard, Britt & Brørs, Gunhild [Show all 20 contributors for this article] (2020). Rethinking rehabilitation after percutaneous coronary intervention: a protocol of a multicentre cohort study on continuity of care, health literacy, adherence and costs at all care levels (the CONCARDPCI). BMJ Open. ISSN 2044-6055. 10. doi: 10.1136/bmjopen-2019-031995. Full text in Research Archive
• Kvisvik, Brede Alexander; Aagaard, Erika Nerdrum; Mørkrid, Lars; Røsjø, Helge; Lyngbakken, Magnus & Smedsrud, Marit Kristine [Show all 11 contributors for this article] (2019). Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease. The International Journal of Cardiovascular Imaging. ISSN 1569-5794. 35, p. 1265–1275. doi: 10.1007/s10554-019-01583-z. Full text in Research Archive
• Lunde, Ngoc Dieu Nguyen; Gregersen, Ida; Ueland, Thor; Shetelig, Christian; Holm, Sverre & Kong, Xiang Yi [Show all 31 contributors for this article] (2019). Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages. Atherosclerosis. ISSN 0021-9150. p. 1–9. doi: 10.1016/j.atherosclerosis.2019.12.008. Full text in Research Archive
• Bendz, Bjørn; Gude, Einar; Ragnarsson, Asgrimur; Endresen, Knut; Aaberge, Lars & Geiran, Odd [Show all 7 contributors for this article] (2019). Intra-aortic balloon pump in acute chest pain and cardiogenic shock - a long-term follow-up. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 53(6), p. 337–341. doi: 10.1080/14017431.2019.1657938.
• Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Broch, Kaspar; Bendz, Bjørn & Aakhus, Svend [Show all 19 contributors for this article] (2019). Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI). Open heart. ISSN 2053-3624. 6(2), p. 1–9. doi: 10.1136/openhrt-2019-001108. Full text in Research Archive
• Munkhaugen, John; Ruddox, Vidar; Halvorsen, Sigrun; Dammen, Toril; Fagerland, Morten & Hernæs, Kjersti Helene [Show all 23 contributors for this article] (2019). BEtablocker Treatment After acute Myocardial Infarction in revascularized patients without reduced left ventricular ejection fraction (BETAMI): Rationale and design of a prospective, randomized, open, blinded end-point study. American Heart Journal. ISSN 0002-8703. 208, p. 37–46. doi: 10.1016/j.ahj.2018.10.005. Full text in Research Archive
• Buer, Øystein; Kalfoss, Mary; Weisæth, Lars; Stifoss-Hanssen, Hans & Bendz, Bjørn (2018). Near- Death Experience Features During Various Phases Related to Unconsciousness: An Exploratory Study of Norwegian Hospital Patients . Journal of Near-Death Studies. ISSN 0891-4494. 36(4), p. 219–231. doi: 10.17514/JNDS-2018-36-4-p219-231..
• Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne & Ekholt, Karin [Show all 18 contributors for this article] (2018). IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction. Frontiers in Immunology. ISSN 1664-3224. 9. doi: 10.3389/fimmu.2018.02035. Full text in Research Archive
• Ruddox, Vidar; Otterstad, Jan Erik; Atar, Dan; Bendz, Bjørn & Edvardsen, Thor (2018). In Current Clinical Practice, after Percutaneous Coronary Intervention for Acute Myocardial Infarction, Are β-Blockers Prescribed for Heart Failure or as Secondary Prevention? A Pilot Study. Cardiology. ISSN 0008-6312. 140(3), p. 152–154. doi: 10.1159/000490656.
• Pettersen, Trond Røed; Fridlund, Bengt Gotthard Anton; Bendz, Bjørn; Nordrehaug, Jan Erik; Rotevatn, Svein & Schjøtt, Jan [Show all 7 contributors for this article] (2018). Challenges adhering to a medication regimen following first-time percutaneous coronary intervention: A patient perspective. International Journal of Nursing Studies. ISSN 0020-7489. 88, p. 16–24. doi: 10.1016/j.ijnurstu.2018.07.013. Full text in Research Archive
• Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne & Broch, Kaspar [Show all 18 contributors for this article] (2018). Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction. International Journal of Cardiology. ISSN 0167-5273. 271, p. 1–7. doi: 10.1016/j.ijcard.2018.04.136. Full text in Research Archive
• Tegn, Nicolai Kloumann; Abdelnoor, Michael; Aaberge, Lars; Ranhoff, Anette Hylen; Endresen, Knut & Gjertsen, Erik [Show all 9 contributors for this article] (2018). Health-related quality of life in older patients with acute coronary syndrome randomised to an invasive or conservative strategy. The After Eighty randomised controlled trial. Age and Ageing. ISSN 0002-0729. 47(1), p. 42–47. doi: 10.1093/ageing/afx121.
• Hauge, Karoline Kråkmo; Dahle, Gry; Bendz, Bjørn; Halvorsen, Per Steinar; Abdelnoor, Michael & Mollnes, Tom Eirik [Show all 7 contributors for this article] (2018). Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 52(1), p. 43–50. doi: 10.1080/14017431.2017.1416157. Full text in Research Archive
• Kvisvik, Brede Alexander; Mørkrid, Lars; Røsjø, Helge; Småstuen, Milada C; Rowe, Alexander D. & Eek, Christian [Show all 9 contributors for this article] (2017). Troponinas de alta sensibilidad T vs I en Sindrome Coronario Agudo: Prediccion de lesiones coronarias significativas y pronostico a largo plazo. Acta Bioquimica Clinica Latinoamericana. ISSN 0325-2957. 51(3), p. 395–407.
• Auensen, Andreas; Hussain, Amjad; Bendz, Bjørn; Aaberge, Lars; Falk, Ragnhild Sørum & Walle-Hansen, Marte [Show all 12 contributors for this article] (2017). Morbidity outcomes after surgical aortic valve replacement. Open heart. ISSN 2053-3624. 4(1). doi: 10.1136/openhrt-2017-000588.
• Holte, Espen; Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte & Broch, Kaspar [Show all 14 contributors for this article] (2017). Effect of interleukin-6 inhibition on coronary microvascular and endothelial function in myocardial infarction. Heart. ISSN 1355-6037. 103(19), p. 1521–1527. doi: 10.1136/heartjnl-2016-310875.
• Yardley, Marianne; Gullestad, Lars; Bendz, Bjørn; Bjørkelund, Elisabeth; Rolid, Katrine & Arora, Satish [Show all 7 contributors for this article] (2017). Long-term effects of high-intensity interval training in heart transplant recipients: A 5-year follow-up study of a randomized controlled trial. Clinical Transplantation. ISSN 0902-0063. 31(1). doi: 10.1111/ctr.12868.
• Kvisvik, Brede Alexander; Mørkrid, Lars; Røsjø, Helge; Småstuen, Milada Cvancarova; Rowe, Alexander D. & Eek, Christian [Show all 9 contributors for this article] (2017). High-Sensitivity Troponin T vs I in Acute Coronary Syndrome: Prediction of Significant Coronary Lesions and Long-term Prognosis. Clinical Chemistry. ISSN 0009-9147. 63(2), p. 552–562. doi: 10.1373/clinchem.2016.261107.
• Eidet, Jo; Dahle, Gry; Bugge, Jan F; Bendz, Bjørn; Rein, Kjell Arne & Aaberge, Lars [Show all 10 contributors for this article] (2016). Long-term outcomes after transcatheter aortic valve implantation: The impact of intraoperative tissue Doppler echocardiography. Interactive Cardiovascular and Thoracic Surgery. ISSN 1569-9293. 23(3), p. 403–409. doi: 10.1093/icvts/ivw159.
• Bønaa, Kaare; Mannsverk, Jan Torbjørn; Wiseth, Rune; Aaberge, Lars; Myreng, Yngvar & Nygård, Ottar [Show all 25 contributors for this article] (2016). Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease . New England Journal of Medicine. ISSN 0028-4793. 375(13), p. 1242–1252. doi: 10.1056/NEJMoa1607991.
• Kleveland, Ola; Kunszt, Gabor; Bratlie, Marte; Ueland, Thor; Broch, Kaspar & Holte, Espen [Show all 15 contributors for this article] (2016). Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial. European Heart Journal. ISSN 0195-668X. 37(30), p. 2406–2413. doi: 10.1093/eurheartj/ehw171. Full text in Research Archive
• Tegn, Nicolai Kloumann; Abdelnoor, Michael; Aaberge, Lars; Endresen, Knut; Smith, Pål & Aakhus, Svend [Show all 11 contributors for this article] (2016). Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): An open-label randomised controlled trial. The Lancet. ISSN 0140-6736. 387(10023), p. 1057–1065. doi: 10.1016/S0140-6736(15)01166-6.
• Eidet, Jo; Dahle, Gry; Bugge, Jan F; Bendz, Bjørn; Rein, Kjell Arne & Aaberge, Lars [Show all 10 contributors for this article] (2016). Intraoperative improvement in left ventricular peak systolic velocity predicts better short-term outcome after transcatheter aortic valve implantation. Interactive Cardiovascular and Thoracic Surgery. ISSN 1569-9293. 22(1), p. 5–12. doi: 10.1093/icvts/ivv277.
• Eidet, Jo; Dahle, Gry; Bugge, Jan F; Bendz, Bjørn; Rein, Kjell Arne & Fosse, Erik [Show all 8 contributors for this article] (2015). Transcatheter aortic valve implantation and intraoperative left ventricular function: A myocardial tissue Doppler imaging study. Journal of Cardiothoracic and Vascular Anesthesia. ISSN 1053-0770. 29(1), p. 115–120. doi: 10.1053/j.jvca.2014.10.016.
• Smedsrud, Marit Kristine; Gravning, Jørgen A.; Omland, Torbjørn; Eek, Christian; Mørkrid, Lars & Skulstad, Helge [Show all 10 contributors for this article] (2015). Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain. The International Journal of Cardiovascular Imaging. ISSN 1569-5794. 31(5), p. 967–973. doi: 10.1007/s10554-015-0646-6.
• Halvorsen, Bente ; Smedbakken, Linda Merete; Michelsen, Annika ; Skjelland, Mona; Bjerkeli, Vigdis & Sagen, Ellen Lund [Show all 12 contributors for this article] (2014). Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13. Atherosclerosis. ISSN 0021-9150. 234(2), p. 352–359. doi: 10.1016/j.atherosclerosis.2014.03.021.
• Aakre, Kristin; Rotevatn, Svein; Hagve, Tor-Arne; Bendz, Bjørn; Landaas, Sverre & Trovik, Thor (2013). Nasjonale anbefalinger for tolkning av troponinverdier ved diagnostikk av akutt hjerteinfarkt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. doi: 10.4045/tidsskr.13.0647.
• Sarvari, Sebastian Imre; Haugaa, Kristina; Zahid, Wasim; Bendz, Bjørn; Aakhus, Svend & Aaberge, Lars [Show all 7 contributors for this article] (2013). Layer-Specific Quantification of Myocardial Deformation by Strain Echocardiography May Reveal Significant CAD in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome. Journal of the American College of Cardiology. ISSN 0735-1097. 6(5), p. 535–544. doi: 10.1016/j.jcmg.2013.01.009.
• Gravning, Jørgen A.; Smedsrud, Marit Kristine; Omland, Torbjørn; Eek, Christian; Skulstad, Helge & Aaberge, Lars [Show all 10 contributors for this article] (2013). Sensitive troponin assays and N-terminal pro-B-type natriuretic peptide in acute coronary syndrome: Prediction of significant coronary lesions and long-term prognosis. American Heart Journal. ISSN 0002-8703. 165(5), p. 716–724. doi: 10.1016/j.ahj.2013.02.008.
• Gullestad, Lars; Ørn, Stein; Dickstein, Kenneth; Eek, Christian; Edvardsen, Thor & Aakhus, Svend [Show all 14 contributors for this article] (2013). Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction. International Journal of Cardiology. ISSN 0167-5273. 168(1), p. 212–218. doi: 10.1016/j.ijcard.2012.09.092. Show summary

  BACKGROUND: Left ventricular (LV) remodeling takes place after acute myocardial infarction (MI), potentially leading to overt heart failure (HF). Enhanced inflammation may contribute to LV remodeling. Our hypothesis was that the immunomodulating effects of intravenous immunoglobulin (IVIg) would be beneficial in patients with impaired myocardial function after MI by reducing myocardial remodeling and improving myocardial function. METHODS: Sixty-two patients with acute MI treated by percutaneous coronary intervention, with depressed LV ejection fraction (LVEF) were randomized in a double-blinded fashion to IVIg as induction therapy and thereafter as monthly infusions or placebo for 26weeks. The primary end point was changes in LVEF from baseline to 6months as assessed by MRI. RESULTS: Our main findings were: (i) LVEF increased significantly from 38±10 (mean±SD) to 45±13% after IVIg and from 42±9 to 49±12% after placebo with no difference between the groups. (ii) The scar area decreased significantly by 3% and 5% in the IVIg and placebo group, respectively, with no difference between the groups. (iii) During the induction therapy (baseline to day 5), IVIg induced both inflammatory (e.g., increase in tumor necrosis factor α and monocyte chemoattractant protein-1) and anti-inflammatory (e.g., increase in interleukin-10 and decrease in leukocyte counts) variables, but during maintenance therapy there were no differences in changes of inflammatory mediators between IVIg and placebo. CONCLUSIONS: IVIg therapy after ST elevation MI managed by primary PCI does not affect LV remodeling or function. This illustrates the challenges of therapeutic intervention directed against the cytokine network, to prevent post-MI remodeling.

• Erikssen, Gunnar; Liestøl, Knut; Gullestad, Lars; Haugaa, Kristina; Bendz, Bjørn & Amlie, Jan Peder (2012). The Terminal Part of the QT Interval (T peak to T end): A Predictor of Mortality after Acute Myocardial Infarction. Annals of Noninvasive Electrocardiology. ISSN 1082-720X. 17(2), p. 85–94. doi: 10.1111/j.1542-474X.2012.00493.x.
• Meen, Øystein; Brosstad, Frank Roger; Liestøl, Knut; Kunszt, Gabor; Bendz, Bjørn & Wettergreen, Marianne [Show all 9 contributors for this article] (2012). Sequential ADP-stimulated light transmission and multiple electrode aggregometry in patients taking aspirin and clopidogrel after non ST-elevation myocardial infarction. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 72(4), p. 318–325. doi: 10.3109/00365513.2012.666565.
• Arora, Satish; Ueland, Thor; Wennerblom, Bertil; Sigurdadottir, Vilborg; Eiskjær, Hans & Bøtker, Hans Erik [Show all 16 contributors for this article] (2011). Effect of Everolimus Introduction on Cardiac Allograft Vasculopathy-Results of a Randomized, Multicenter Trial. Transplantation. ISSN 0041-1337. 92(2), p. 235–243. doi: 10.1097/TP.0b013e31822057f1.
• Aasheim, Anders; Bendz, Bjørn; Mangschau, Arild; Wik, Lars; Steen, Petter Andreas & Braarud, Anne-Cathrine (2003). Prehospitalt EKG forkorter tiden til utblokking ved akutt hjerteinfarkt i Oslo. Tidsskrift for Den norske legeforening. ISSN 0029-2001.

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• Pettersen, Trond Røed; Schjøtt, Jan Didrik; Allore, Heather; Bendz, Bjørn; Borregard, Britt & Fridlund, Bengt [Show all 14 contributors for this article] (2023). Sex differences in incidence of self-reported adverse drug reactions after percutaneous coronary intervention. European Heart Journal. ISSN 0195-668X. 44.
• Aarskog, Nikolai Ravn; Iuell, Ragnhild Skari; Dunlop, Oona Borghild; Sevre, Knut; Bendz, Bjørn & Rostrup, Morten (2023). Neuropsychological function is associated with hypocapnia at simulated high altitude. Acta Physiologica. ISSN 1748-1708. doi: 10.1111/apha.13949.
• Pettersen, Trond Røed; Schjøtt, Jan Didrik; Allore, Heather; Bendz, Bjørn; Fridlund, Bengt & Larsen, Alf Inge [Show all 10 contributors for this article] (2022). Informing patients about potential adverse drug reactions after percutaneous coronary intervention reduces the occurrence of self-reported adverse drug reactions.
• Pettersen, Trond Røed; Schjøtt, Jan Didrik; Bendz, Bjørn; Borregaard, Britt; Fridlund, Bengt & Larsen, Alf Inge [Show all 10 contributors for this article] (2021). Perceptions of efficacy and safety of generic medicines in patients after percutaneous coronary intervention. European Heart Journal. ISSN 0195-668X. 42. doi: 10.1093/eurhaertj/ehab724.3020.
• Pettersen, Trond Røed; Allore, Heather; Bendz, Bjørn; Borregaard, Britt; Fridlund, Bengt & Ghaderi, Sara [Show all 13 contributors for this article] (2021). Communication of Potential Adverse Drug Reactions in Patients Undergoing Percutaneous Coronary Intervention. Circulation. ISSN 0009-7322. 144.
• Bjørnstad, Johannes & Bendz, Bjørn (2020). Periprocedural myocardial injury in the EXCEL trial. European Heart Journal. ISSN 0195-668X. 41(17). doi: 10.1093/eurheartj/ehaa182.
• Pettersen, Trond Røed; Schjøtt, Jan; Allore, Heather; Bendz, Bjørn; Larsen, Alf Inge & Nordrehaug, Jan E [Show all 9 contributors for this article] (2019). Patients’ Perceptions of Generic Drugs After Percutaneous Coronary Intervention: A Multicentre Cohort Study. Circulation. ISSN 0009-7322. 140.
• Pettersen, Trond Røed; Schjøtt, Jan; Bendz, Bjørn; Fridlund, Bengt; Nordrehaug, Jan Erik & Rotevatn, Svein [Show all 7 contributors for this article] (2018). Discontinuation of drug treatment due to side effects after first-time percutaneous coronary intervention: a patient perspective.
• Tegn, Nicolai Kloumann; Abdelnoor, Michael; Aaberge, Lars; Endresen, Knut; Gullestad, Lars & Bendz, Bjørn (2016). Re: Over 80 år og hjerteinfarkt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(16), p. 1324–1325. doi: 10.4045/tidsskr.16.0685.
• Buer, Øystein; Kalfoss, Mary; Weisæth, Lars & Bendz, Bjørn (2016). Kartlegging av nær døden-opplevelser. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(23/24), p. 1968–1969. doi: 10.4045/tidsskr.16.0953.
• Tegn, Nicolai Kloumann; Abdelnoor, Michael; Aaberge, Lars; Endresen, Knut & Bendz, Bjørn (2016). Invasive strategy in acute coronary syndrome - Authors' reply. The Lancet. ISSN 0140-6736. 387(10037). doi: 10.1016/S0140-6736(16)30673-0.
• Aaberge, Lars; Bendz, Bjørn; Beitnes, Jan Otto & Busund, Rolf (2015). TAVI - kateterbasert behandling av aortastenose. In Wiseth, Rune; Forfang, Kolbjørn & Istad, Helge (Ed.), Kardiologi, Klinisk veileder. Gyldendal Akademisk. ISSN 9788205484580. p. 265–271.

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