Caroline Sophie Verbeke

• Vendittelli, Pierpaolo; Bokhorst, John-Melle; Smeets, Esther M M; Kryklyva, Valentyna; Brosens, Lodewijk A A & Verbeke, Caroline Sophie [Show all 7 contributors for this article] (2024). Automatic quantification of tumor-stroma ratio as a prognostic marker for pancreatic cancer. PLOS ONE. ISSN 1932-6203. 19(5). doi: 10.1371/journal.pone.0301969.
• Holm, Maia Blomhoff; Lenggenhager, Daniela; Detlefsen, Sönke; Sántha, Petra & Verbeke, Caroline Sophie (2024). Identification of tumour regression in neoadjuvantly treated pancreatic cancer is based on divergent and nonspecific criteria. Histopathology. ISSN 0309-0167. doi: 10.1111/his.15190.
• Leonhardt, Carl-Stephan; Hank, Thomas; Pils, Dietmar; Gustorff, Charlotte; Sahora, Klaus & Schindl, Martin [Show all 9 contributors for this article] (2024). Prognostic impact of resection margin status on survival after neoadjuvant treatment for pancreatic cancer: systematic review and meta-analysis. International Journal of Surgery (IJS). ISSN 1743-9191. 110(1), p. 453–463. doi: 10.1097/JS9.0000000000000792.
• Labori, Knut Jørgen; Bratlie, Svein Olav; Andersson, Bodil; Angelsen, Jon-Helge; Biörserud, Christina & Björnsson, Bergthor [Show all 36 contributors for this article] (2024). Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial. The Lancet Gastroenterology and Hepatology. ISSN 2468-1253. 9(3), p. 205–217. doi: 10.1016/S2468-1253(23)00405-3.
• Farnes, Ingvild; Kleive, Dyre; Verbeke, Caroline Sophie; Aabakken, Lars; Issa-Epe, Aart Imran & Småstuen, Milada Cvancarova [Show all 10 contributors for this article] (2023). Resection rates and intention-to-treat outcomes in borderline and locally advanced pancreatic cancer: real-world data from a population-based, prospective cohort study (NORPACT-2). BJS Open. ISSN 2474-9842. 7:zrad137(6), p. 1–10. doi: 10.1093/bjsopen/zrad137. Full text in Research Archive
• Farnes, Ingvild; Paulsen, Vemund; Verbeke, Caroline Sophie; Tønnesen, Christer Julseth; Aabakken, Lars & Labori, Knut Jørgen (2023). Performance and safety of diagnostic EUS FNA/FNB and therapeutic ERCP in patients with borderline resectable and locally advanced pancreatic cancer - results from a population-based, prospective cohort study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 0, p. 1–7. doi: 10.1080/00365521.2023.2290456. Full text in Research Archive
• Li, Yuchuan; Amrutkar, Manoj; Finstadsveen, Anette V.; Dalen, Knut Tomas; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2023). Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells. Cancer Cell International. ISSN 1475-2867. 23. doi: 10.1186/s12935-023-03138-8. Full text in Research Archive
• Korrel, Maarten; Jones, Leia R.; van Hilst, Jony; Balzano, Gianpaolo; Björnsson, Bergthor & Boggi, Ugo [Show all 50 contributors for this article] (2023). Minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer (DIPLOMA): an international randomised non-inferiority trial. The Lancet Regional Health - Europe. ISSN 2666-7762. 31, p. 1–15. doi: 10.1016/j.lanepe.2023.100673. Full text in Research Archive
• Amrutkar, Manoj; Berg, Kjersti; Balto, Aina; Skilbrei, Miguel Garcia; Finstadsveen, Anette Vefferstad & Aasrum, Monica [Show all 8 contributors for this article] (2023). Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis. Cancer Cell International. ISSN 1475-2867. 23, p. 1–17. doi: 10.1186/s12935-023-02852-7. Full text in Research Archive
• Janssen, Boris V.; van Roessel, Stijn; van Dieren, Susan; de Boer, Onno; Adsay, Volkan & Basturk, Olca [Show all 30 contributors for this article] (2022). Histopathological tumour response scoring in resected pancreatic cancer following neoadjuvant therapy: international interobserver study (ISGPP-1). British Journal of Surgery. ISSN 0007-1323. 110(1), p. 67–75. doi: 10.1093/bjs/znac350. Full text in Research Archive
• Amrutkar, Manoj; Verbeke, Caroline Sophie; Vefferstad, Anette; Dorg, Linda Trobe; Labori, Knut Jørgen & Gladhaug, Ivar Prydz (2022). Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma. Molecular Oncology. ISSN 1574-7891. 17(1), p. 59–81. doi: 10.1002/1878-0261.13344. Full text in Research Archive Show summary

  he modest clinical benefits of neoadjuvant chemotherapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) are associated with a lack of robust data on treatment-induced changes in the tumor. To this end, comparative proteomic profiling of tumor tissue samples from treatment-naïve (TN, n = 20) and NAT-treated (n = 22) PDACs was performed. Differentially expressed proteins were identified and correlation with overall survival (OS) was performed. Tumors were also examined for histopathological changes and expression of cancer stem cell (CSC) markers. Serum from 33 matched patients was analyzed for metabolic markers. Cytotoxicity, proliferation, and expression of CSC markers were assessed in chemoresistant Panc-1 and Mia PaCa-2 cells. Of the 2265 proteins identified, 227 and 144 proteins showed significantly altered expression and differential phosphorylation, respectively, in NAT compared with TN samples. The majority of these were metabolism-related proteins, and 14 of these correlated moderately with OS. NAT-treated tumors and chemoresistant cancer cells showed increased expression of CSC markers. Serum ALDH1A1 was higher in NAT compared with TN. Differentially phosphorylated proteins were mainly involved in cytoskeleton organization, cell locomotion, motility, and migration, and 17 of these showed a strong positive correlation with OS. This study provides evidence of the effects of NAT on PDAC metabolism at both the tumor and the systemic levels. NAT-treated tumors showed significantly lower expression of metabolic proteins, and patients who underwent NAT showed reduced serum lactate and high-density lipoprotein-cholesterol. Lastly, cancer cells that survived cytotoxic treatment expressed higher CSC markers, both in vivo and in vitro.

• Fjeld, Karianne; Svanbring, Anny Gravdal; Brekke, Ranveig Seim; Alam, Jahedul; Wilhelm, Steven J. & el Jellas, Khadija [Show all 16 contributors for this article] (2022). The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice. Pancreatology (Print). ISSN 1424-3903. 22(8), p. 1099–1111. doi: 10.1016/j.pan.2022.11.003. Full text in Research Archive
• Holm, Maia Blomhoff & Verbeke, Caroline Sophie (2022). Prognostic Impact of Resection Margin Status on Distal Pancreatectomy for Ductal Adenocarcinoma. Current Oncology. ISSN 1198-0052. 29(9), p. 6551–6563. doi: 10.3390/curroncol29090515. Full text in Research Archive
• Tran, My Linh; Holm, Maia Blomhoff & Verbeke, Caroline Sophie (2022). Tumour Size and T-Stage in Pancreatic Cancer Resection Specimens Depend on the Pathology Examination Approach. Cancers. ISSN 2072-6694. 14(10), p. 1–17. doi: 10.3390/cancers14102471. Full text in Research Archive
• Vujasinovic, Miroslav; Pozzi Mucelli, Raffaella; Grigoriadis, Aristeidis; Palmér, Isabella; Asplund, Ebba & Rutkowski, Wiktor [Show all 11 contributors for this article] (2022). Paraduodenal pancreatitis – problem in the groove. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 00, p. 1–8. doi: 10.1080/00365521.2022.2036806. Full text in Research Archive
• Nikolic, Sara; Ghorbani, Poya; Pozzi Mucelli, Raffaella; Ghazi, Sam; Baldaque-Silva, Francisco & Del Chiaro, Marco [Show all 10 contributors for this article] (2022). Surgery in Autoimmune Pancreatitis. Digestive Surgery. ISSN 0253-4886. 39(1), p. 32–41. doi: 10.1159/000521490. Full text in Research Archive
• Janssen, Boris V.; Tutucu, Faik; van Roessel, Stijn; Adsay, Volkan; Basturk, Olca & Campbell, Fiona [Show all 32 contributors for this article] (2021). Amsterdam International Consensus Meeting: tumor response scoring in the pathology assessment of resected pancreatic cancer after neoadjuvant therapy. Modern Pathology. ISSN 0893-3952. 34(1), p. 4–12. doi: 10.1038/s41379-020-00683-9. Full text in Research Archive
• Soer, Eline C. & Verbeke, Caroline Sophie (2021). Pathology reporting of margin status in locally advanced pancreatic cancer: challenges and uncertainties. Journal of Gastrointestinal Oncology (JGO). ISSN 2078-6891. 12(5), p. 2512–2520. doi: 10.21037/jgo-20-391. Full text in Research Archive
• van Hilst, Jony; Korrel, Maarten; Lof, Sanne; de Rooij, Thijs; Vissers, Frederique L. & Edwin, Bjørn von Gohren [Show all 50 contributors for this article] (2021). Minimally invasive versus open distal pancreatectomy for pancreatic ductal adenocarcinoma (DIPLOMA): study protocol for a randomized controlled trial. Trials. ISSN 1745-6215. 22:608, p. 1–11. doi: 10.1186/s13063-021-05506-z.
• Verbeke, Caroline Sophie; Webster, Fleur; Brosens, Lodewijk; Campbell, Fiona M.; Del Chiaro, Marco & Esposito, Irene [Show all 15 contributors for this article] (2021). Dataset for the reporting of carcinoma of the exocrine pancreas: recommendations from the International Collaboration on Cancer Reporting (ICCR). Histopathology. ISSN 0309-0167. 79(6), p. 902–912. doi: 10.1111/his.14540. Full text in Research Archive
• Van Roessel, Stijn; Janssen, Boris V.; Soer, Eline C.; Farina Sarasqueta, Arantza; Verbeke, Caroline Sophie & Luchini, Claudio [Show all 9 contributors for this article] (2021). Scoring of tumour response after neoadjuvant therapy in resected pancreatic cancer: systematic review. British Journal of Surgery. ISSN 0007-1323. 108(2), p. 119–127. doi: 10.1093/bjs/znaa031. Full text in Research Archive
• Rasmussen, Lukas Gammelgaard; Verbeke, Caroline Sophie; Sørensen, Mia Dahl; Pfeiffer, Per; Tan, Qihua & Mortensen, Michael Bau [Show all 8 contributors for this article] (2021). Gene expression profiling of morphologic subtypes of pancreatic ductal adenocarcinoma using surgical and EUS-FNB specimens. Pancreatology (Print). ISSN 1424-3903. 21(3), p. 530–543. doi: 10.1016/j.pan.2021.01.025. Full text in Research Archive
• Sahakyan, Mushegh A.; Verbeke, Caroline S.; Tholfsen, Tore; Ignjatovic, Dejan; Kleive, Dyre & Buanes, Trond [Show all 10 contributors for this article] (2021). Prognostic Impact of Resection Margin Status in Distal Pancreatectomy for Ductal Adenocarcinoma. Annals of Surgical Oncology. ISSN 1068-9265. 29, p. 366–375. doi: 10.1245/s10434-021-10464-6. Full text in Research Archive
• Santha, Petra; Lenggenhager, Daniela; Vefferstad, Anette; Dorg, Linda Trobe; Tøndel, Kristin & Amrutkar, Manoj [Show all 8 contributors for this article] (2021). Morphological heterogeneity in pancreatic cancer reflects structural and functional divergence. Cancers. ISSN 2072-6694. 13(4). doi: 10.3390/cancers13040895. Full text in Research Archive Show summary

  Pancreatic cancer has a poor prognosis, which is largely due to resistance to treatment. Tumor heterogeneity is a known cause for treatment failure and has been studied at the molecular level. Morphological heterogeneity is common but has not been investigated, despite the fact that pathology examination is an integral part of clinical diagnostics. This study assessed whether morphological heterogeneity reflects structural and functional diversity in key cancer biological processes. Using archival tissues from resected pancreatic cancer, we selected four common and distinct morphological phenotypes and demonstrated that these differed significantly for a panel of 26 structural and functional features of the cancer-cell and stromal compartments. The strong link between these features and morphological phenotypes allowed prediction of the latter based on the results for the panel of features. The findings of this study indicate that morphological heterogeneity reflects biological diversity and that its assessment may potentially provide clinically relevant information.

• Esposito, Irene; Hruban, Ralph H.; Verbeke, Caroline Sophie; Terris, Benoit; Zamboni, Giuseppe & Scarpa, Aldo [Show all 20 contributors for this article] (2020). Guidelines on the histopathology of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and the European Pancreatic Club. Pancreatology (Print). ISSN 1424-3903. 20(4), p. 586–593. doi: 10.1016/j.pan.2020.04.009.
• Cobo, Isidoro; Iglesias, Mar; Flández, Marta; Verbeke, Caroline Sophie; del Pozo, Natalia & Llorente, Miriam [Show all 11 contributors for this article] (2020). Epithelial Nr5a2 heterozygosity cooperates with mutant Kras in the development of pancreatic cystic lesions. Journal of Pathology. ISSN 0022-3417. 253(2), p. 174–185. doi: 10.1002/path.5570.
• Löhr, J.-Matthias; Beuers, Ulrich; Vujasinovic, Miroslav; Alvaro, Domenico; Frøkjær, Jens Brøndum & Verbeke, Caroline Sophie [Show all 51 contributors for this article] (2020). European Guideline on IgG4-related digestive disease – UEG and SGF evidence-based recommendations. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 8(6), p. 637–666. doi: 10.1177/2050640620934911. Full text in Research Archive
• Ghaderi, Mehran; Moro, Carlos Fernández; Elduayen, Soledad Pouso; Hultin, Emilie; Verbeke, Caroline Sophie & Björnstedt, Mikael [Show all 7 contributors for this article] (2020). Genome-wide transcriptome profiling of ex-vivo precision-cut slices from human pancreatic ductal adenocarcinoma. Scientific Reports. ISSN 2045-2322. 10:9070, p. 1–8. doi: 10.1038/s41598-020-65911-3. Full text in Research Archive
• Vujasinovic, Miroslav; Maier, Pia; Maetzel, Hartwig; Valente, Roberto; Pozzi-Mucelli, Raffaella & Moro, Carlos F. [Show all 11 contributors for this article] (2020). Immunoglobulin G subtypes-1 and 2 differentiate immunoglobulin G4-associated sclerosing cholangitis from primary sclerosing cholangitis. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 8(5), p. 584–593. doi: 10.1177/2050640620916027. Full text in Research Archive
• Wesali, Sahar; Demir, Mehmet A.; Verbeke, Caroline Sophie; Andersson, Mats; Bratlie, Svein Olav & Sadik, Riadh (2020). EUS is accurate in characterizing pancreatic cystic lesions; a prospective comparison with cross-sectional imaging in resected cases. Surgical Endoscopy. ISSN 0930-2794. p. 1–10. doi: 10.1007/s00464-020-08166-3. Full text in Research Archive
• Amrutkar, Manoj; Vethe, Nils Tore; Verbeke, Caroline Sophie; Aasrum, Monica; Vefferstad, Anette & Santha, Petra [Show all 7 contributors for this article] (2020). Differential gemcitabine sensitivity in primary human pancreatic cancer cells and paired stellate cells is driven by heterogenous drug uptake and processing. Cancers. ISSN 2072-6694. 12:3628(12), p. 1–18. doi: 10.3390/cancers12123628. Full text in Research Archive
• Hugenschmidt, Harald; Labori, Knut Jørgen; Brunborg, Cathrine; Verbeke, Caroline Sophie; Seeberg, Lars Thomas & Schirmer, Cecilie [Show all 10 contributors for this article] (2020). Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information . BMC Cancer. ISSN 1471-2407. 20:1107, p. 1–13. doi: 10.1186/s12885-020-07510-z. Full text in Research Archive Show summary

  Background: Pancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a variety of epithelial cancers. In a cohort of patients with presumed resectable pancreatic and periampullary carcinoma, we evaluated the frequency and the potential prognostic impact of the preoperative presence of DTC, defined as cytokeratin-positive cells detected by immunocytochemistry (ICC). Methods: Preoperative BM samples from 242 patients selected for surgical resection of presumed resectable pancreatic and periampullary carcinoma from 09/2009 to 12/2014, were analysed for presence of CK-positive cells by ICC. The median observation time was 21.5 months. Overall survival (OS) and disease-free survival (DFS) were calculated by Kaplan-Meier and Cox regression analysis. Results: Successful resections of malignant tumours were performed in 179 of the cases, 30 patients resected had benign pancreatic disease based on postoperative histology, and 33 were deemed inoperable intraoperatively due to advanced disease. Overall survival for patients with resected carcinoma was 21.1 months (95% CI: 18.0-24.1), for those with benign disease OS was 101 months (95% CI: 69.4-132) and for those with advanced disease OS was 8.8 months (95% CI: 4.3-13.3). The proportion of patients with detected CK-positive cells was 6/168 (3.6%) in resected malignant cases, 2/31 (6.5%) in advanced disease and 4/29 (13.8%) in benign disease. The presence of CK-positive cells was not correlated to OS or DFS, neither in the entire cohort nor in the subgroup negative for circulating tumour cells (CTC). Conclusions: The results indicate that CK-positive cells may be present in both patients with malignant and benign diseases of the pancreas. Detection of CK-positive cells was not associated with differences in prognosis for the entire cohort or any of the subgroups analysed.

• Lof, Sanne; Rajak, Rushda; Vissers, Frederique L.; Korrel, Maarten; Bateman, Adrian & Verheij, Johanna [Show all 10 contributors for this article] (2020). DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens. Journal of Visualized Experiments. ISSN 1940-087X. 156:e60343, p. 1–7. doi: 10.3791/60343.
• Amrutkar, Manoj; Larsen, Emma Kristine; Aasrum, Monica; Finstadsveen , Anette Vefferstad; Andresen, Per Arne & Verbeke, Caroline Sophie [Show all 7 contributors for this article] (2020). Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor. Cells. ISSN 2073-4409. 9:227(1), p. 1–18. doi: 10.3390/cells9010227. Full text in Research Archive
• Vujasinovic, Miroslav; Pozzi Mucelli, Raffaella Maria; Valente, Roberto; Verbeke, Caroline Sophie; Haas, Stephan L. & Löhr, J.-Matthias (2019). Kidney involvement in patients with type 1 autoimmune pancreatitis. Journal of Clinical Medicine. ISSN 2077-0383. 8(2), p. 1–10. doi: 10.3390/jcm8020258.
• Held, Thomas; Verbeke, Caroline Sophie; Strobel, Oliver; Rutkowski, Wiktor; Villard, Christina & Moro, Carlos Fernández [Show all 10 contributors for this article] (2019). Immunohistochemical profiling of liver metastases and matched-pair analysis in patients with metastatic pancreatic ductal adenocarcinoma. Pancreatology (Print). ISSN 1424-3903. 19(7), p. 963–970. doi: 10.1016/j.pan.2019.09.005. Full text in Research Archive
• Lenggenhager, Daniela; Amrutkar, Manoj; Santha, Petra; Aasrum, Monica; Löhr, Johannes-Matthias & Gladhaug, Ivar Prydz [Show all 7 contributors for this article] (2019). Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions With Pancreatic Cancer Cells. Cells. ISSN 2073-4409. 8:E23(1), p. 1–18. doi: 10.3390/cells8010023. Full text in Research Archive
• Ånonsen, Kim Vidar; Sahakyan, Mushegh; Kleive, Dyre; Waage, Anne; Verbeke, Caroline Sophie & Hauge, Truls [Show all 9 contributors for this article] (2019). Trends in management and outcome of cystic pancreatic lesions - analysis of 322 cases undergoing surgical resection. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 54(8), p. 1051–1057. doi: 10.1080/00365521.2019.1642379. Full text in Research Archive
• Amrutkar, Manoj; Aasrum, Monica; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2019). Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells. BMC Cancer. ISSN 1471-2407. 19(596). doi: 10.1186/s12885-019-5803-1. Full text in Research Archive
• Misra, Sougat; Moro, Carlos Fernández; Del Chiaro, Marco; Pouso, Soledad; Sebestyen, Anna & Löhr, Matthias [Show all 8 contributors for this article] (2019). Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma. Scientific Reports. ISSN 2045-2322. 9:2133(1), p. 1–16. doi: 10.1038/s41598-019-38603-w. Full text in Research Archive
• Kleive, Dyre; Labori, Knut Jørgen; Line, Pål Dag; Gladhaug, Ivar Prydz & Verbeke, Caroline Sophie (2019). Pancreatoduodenectomy with venous resection for ductal adenocarcinoma rarely achieves complete (R0) resection. HPB. ISSN 1365-182X. 22(1), p. 50–57. doi: 10.1016/j.hpb.2019.05.005. Full text in Research Archive
• Kamposioras, Konstantinos; Tsimplouli, Chrysiida; Verbeke, Caroline Sophie; Anthoney, Alan; Daoukopoulou, Argyro & Papandreou, Christos N [Show all 13 contributors for this article] (2018). Silencing of caveolin-1 in fibroblasts as opposed to epithelial tumor cells results in increased tumor growth rate and chemoresistance in a human pancreatic cancer model. International Journal of Oncology. ISSN 1019-6439. 54(2), p. 537–549. doi: 10.3892/ijo.2018.4640. Full text in Research Archive
• Vujasinovic, Miroslav; Valente, Roberto; Maier, Pia; von Beckerath, Victoria; Haas, Stephan L & Arnelo, Urban [Show all 14 contributors for this article] (2018). Diagnosis, treatment and long-term outcome of autoimmune pancreatitis in Sweden. Pancreatology (Print). ISSN 1424-3903. 18(8), p. 900–904. doi: 10.1016/j.pan.2018.09.003. Full text in Research Archive
• Del Chiaro, Marco; Besselink, Marc G; Bruno, Marco J; Cahen, Djuna L; Gress, Thomas M & Van Hooft, Jeanin E. [Show all 63 contributors for this article] (2018). European evidence-based guidelines on pancreatic cystic neoplasms. The European Study Group on Cystic Tumours of the Pancreas. Gut. ISSN 0017-5749. 67(5), p. 789–804. doi: 10.1136/gutjnl-2018-316027. Full text in Research Archive
• Del Chiaro, Marco; Rangelova, Elena; Halimi, Asif; Ateeb, Zeeshan; Scandavini, Chiara & Valente, Roberto [Show all 9 contributors for this article] (2018). Pancreatectomy with arterial resection is superior to palliation in patients with borderline resectable or locally advanced pancreatic cancer. HPB. ISSN 1365-182X. 21(2), p. 219–225. doi: 10.1016/j.hpb.2018.07.017.
• Hugenschmidt, Harald; Labori, Knut Jørgen; Brunborg, Cathrine; Verbeke, Caroline Sophie; Seeberg, Lars Thomas & Schirmer, Cecilie [Show all 10 contributors for this article] (2018). Circulating Tumor Cells are an Independent Predictor of Shorter Survival in Patients Undergoing Resection for Pancreatic and Periampullary Adenocarcinoma. Annals of Surgery. ISSN 0003-4932. 271(3), p. 549–558. doi: 10.1097/SLA.0000000000003035.
• Löhr, J.-Matthias; Panic, N.; Vujasinovic, Miroslav & Verbeke, Caroline Sophie (2018). The ageing pancreas: a systematic review of the evidence and analysis of the consequences. Journal of Internal Medicine. ISSN 0954-6820. 283(5), p. 446–460. doi: 10.1111/joim.12745.
• Verbeke, Caroline Sophie; Häberle, Lena; Lenggenhager, Daniela & Esposito, Irene (2018). Pathology assessment of pancreatic cancer following neoadjuvant treatment: Time to move on. Pancreatology (Print). ISSN 1424-3903. 18(5), p. 467–476. doi: 10.1016/j.pan.2018.04.010.
• Verbeke, Caroline Sophie (2018). A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer. JOURNAL OF IMMUNOTHERAPY. ISSN 1053-8550. doi: 10.1097/CJI.0000000000000164.
• Sahakyan, Mushegh; Haugvik, Sven-Petter; Røsok, Bård Ingvald; Kazaryan, Airazat M.; Ignjatovic, Dejan & Buanes, Trond [Show all 9 contributors for this article] (2018). Can standardized pathology examination increase the lymph node yield following laparoscopic distal pancreatectomy for ductal adenocarcinoma? HPB. ISSN 1365-182X. 20(2), p. 175–181. doi: 10.1016/j.hpb.2017.08.038.
• Jabbar, Karolina; Sadik, Riadh; Verbeke, Caroline Sophie; Arike, Liisa & Hansson, Gunnar C. (2018). Highly accurate identification of cystic precursor lesions of pancreatic cancer through targeted mass spectrometry: a phase IIc diagnostic study. Journal of Clinical Oncology. ISSN 0732-183X. 36(4), p. 367–375. doi: 10.1200/JCO.2017.73.7288.
• Hessmann, E; Patzak, MS; Klein, L; Chen, N; Kari, V & Ramu, I [Show all 19 contributors for this article] (2018). Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer. Gut. ISSN 0017-5749. 67(3), p. 497–507. doi: 10.1136/gutjnl-2016-311954. Full text in Research Archive
• Verbeke, Caroline Sophie (2017). Operative Specimen Handling and Evaluation of Resection Margins. In Kim, Sun Whe & Yamaue, Hiroki (Ed.), Pancreatic Cancer. With Special Focus on Topical Issues and Surgical Techniques. Springer Publishing Company. ISSN 978-3-662-47180-7. p. 67–87. doi: 10.1007/978-3-662-47181-4_5.
• Verbeke, Caroline Sophie; Löhr, Matthias; Heuchel, Rainer Lothar & Kartalis, Nikolaos (2017). A preliminary report: Radical surgery and stem cell transplantation for the treatment of patients with pancreatic cancer. JOURNAL OF IMMUNOTHERAPY. ISSN 1053-8550. doi: 10.1097/CJI.0000000000000164.
• Gjelberg, Hilde; Hoem, Dag; Verbeke, Caroline Sophie; Eide, Johan; Cooper, John & Molven, Anders (2017). Hypoglycemia and decreased insulin requirement caused by malignant insulinoma in a type 1 diabetic patient: when the hoof beats are from a zebra, not a horse. Clinical Case Reports. ISSN 2050-0904. 5(6), p. 761–768. doi: 10.1002/ccr3.927. Full text in Research Archive
• Malgerud, Linea; Lindberg, Johan; Wirta, Valtteri; Gustavsson-Liljefors, Maria; Karimi, Masoud & Moro, Carlos Fernández [Show all 22 contributors for this article] (2017). Bioinformatory-assisted analysis of next-generation sequencing data for precision medicine in pancreatic cancer. Molecular Oncology. ISSN 1574-7891. 11(10), p. 1413–1429. doi: 10.1002/1878-0261.12108.
• Seleznik, Gitta; Reding, Theresia; Peter, Lukas; Gupta, Anurag; Steiner, Sabrina G & Sonda, Sabrina [Show all 12 contributors for this article] (2017). Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation. Gut. ISSN 0017-5749. 67(9), p. 1663–1673. doi: 10.1136/gutjnl-2016-313458.
• Kleive, Dyre; Berstad, Audun Elnæs; Sahakyan, Mushegh; Verbeke, Caroline Sophie; Naper, Christian & Haugvik, Sven-Petter [Show all 9 contributors for this article] (2017). Portal vein reconstruction using primary anastomosis or venous interposition allograft in pancreatic surgery. Journal of Vascular Surgery: Venous and Lymphatic Disorders (JVS-VL). ISSN 2213-333X. 6(1), p. 66–74. doi: 10.1016/j.jvsv.2017.09.003.
• Kleive, Dyre; Sahakyan, Mushegh; Berstad, Audun Elnæs; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz & Edwin, Bjørn [Show all 9 contributors for this article] (2017). Trends in indications, complications and outcomes for venous resection during pancreatoduodenectomy. British Journal of Surgery. ISSN 0007-1323. 104(11), p. 1558–1567. doi: 10.1002/bjs.10603.
• Strell, Carina; Norberg, Karin Jessica; Mezheyeuski, Artur; Schnittert, Jonas; Kuninty, Praneeth R. & Moro, Carlos Fernández [Show all 16 contributors for this article] (2017). Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC. British Journal of Cancer. ISSN 0007-0920. 117(1), p. 65–77. doi: 10.1038/bjc.2017.140.
• Labori, Knut Jørgen; Lassen, Kristoffer; Hoem, Dag; Grønbech, Jon Erik; Søreide, Jon Arne & Mortensen, Kim Erlend [Show all 10 contributors for this article] (2017). Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) – study protocol for a national multicentre randomized controlled trial. BMC Surgery. ISSN 1471-2482. 17(1). doi: 10.1186/s12893-017-0291-1. Full text in Research Archive
• Del Chiaro, Marco & Verbeke, Caroline Sophie (2017). Intraductal papillary mucinous neoplasms of the pancreas: reporting clinically relevant features. Histopathology. ISSN 0309-0167. 70(6), p. 850–860. doi: 10.1111/his.13131.
• Tjomsland, Vegard; Pomianowska, Ewa; Aasrum, Monica; Sandnes, Dagny Lise; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Profile of MMP and TIMP expression in human pancreatic stellate cells: regulation by IL-1? and TGF? and implications for migration of pancreatic cancer cells. Neoplasia. ISSN 1522-8002. 18(7), p. 447–456. doi: 10.1016/j.neo.2016.06.003.
• Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Dissection of Pancreatic Resection Specimens. Surgical Pathology Clinics. ISSN 1875-9181. 9(4), p. 523–538. doi: 10.1016/j.path.2016.05.001.
• Kleive, Dyre; Berstad, Audun Elnæs; Verbeke, Caroline Sophie; Haugvik, Sven-Petter; Gladhaug, Ivar Prydz & Line, Pål Dag [Show all 7 contributors for this article] (2016). Cold-stored cadaveric venous allograft for superior mesenteric/portal vein reconstruction during pancreatic surgery. HPB. ISSN 1365-182X. 18(7), p. 615–622. doi: 10.1016/j.hpb.2016.05.010. Show summary

  Background SMV/PV resection has become common practice in pancreatic surgery. The aim of this study was to evaluate the technical feasibility and surgical outcome of using cold-stored cadaveric venous allografts (AG) for superior mesenteric vein (SMV) and portal vein (PV) reconstruction during pancreatectomy. Methods Patients who underwent pancreatic resection with concomitant vascular resection and reconstruction with AG between January 2006 and December 2014 were identified from our institutional prospective database. Medical records and pre- and postoperative CT-images were reviewed. Results Forty-five patients underwent SMV/PV reconstruction with AG interposition (n = 37) or AG patch (n = 8). The median operative time and blood loss were 488 min (IQR: 450–551) and 900 ml (IQR: 600-2000), respectively. Major morbidity (Clavien ≥ III) occurred in 16 patients. Four patients were reoperated (thrombosis n = 2, graft kinking/low flow n = 2) and in-hospital mortality occurred in two patients. On last available CT scan, 3 patients had thrombosis, all of whom also had local recurrence. Estimated cumulative patency rate (reduction in SMV/PV luminal diameter <70% and no thrombosis) at 12 months was 52%. Conclusion Cold-stored cadaveric venous AG for SMV/PV reconstruction during pancreatic surgery is safe and associated with acceptable long-term patency.

• Fernández Moro, Carlos; Fernandez-Woodbridge, Alejandro; D'souza,, Melroy Alistair; Zhang,, Qianni; Bozoky, Benedek & Kandaswamy, Senthil Vasan [Show all 16 contributors for this article] (2016). Immunohistochemical typing of adenocarcinoma of the pancreatobiliary system improves diagnosis and prognostic stratification. PLOS ONE. ISSN 1932-6203. 11. doi: 10.1371/journal.pone.0166067.
• Li, Xuan; Nania, Salvatore; Fejzibegovic, Nino; Fernández Moro, Carlos; Klopp-Schulze, Lena & Verbeke, Caroline Sophie [Show all 8 contributors for this article] (2016). Cerulein-induced pancreatic fibrosis is modulated by Smad7, the major negative regulator of transforming growth factor-b signaling. Biochimica et Biophysica Acta - Molecular Basis of Disease. ISSN 0925-4439. 1862, p. 1839–1846. doi: 10.1016/j.bbadis.2016.06.017.
• Verbeke, Caroline Sophie (2016). Expansion of tumor-reactive T cells from patients with pancreatic cancer. JOURNAL OF IMMUNOTHERAPY. ISSN 1053-8550. 30, p. 81–90. doi: 10.1097/cji.0000000000000111.
• Pozzi-Mucelli, Raffaella Maria; Rinta-Kiikka, Irina; Wünsche, Katharina; Laukkarinen, Johanna; Labori, Knut Jørgen & Ånonsen, Kim Vidar [Show all 9 contributors for this article] (2016). Pancreatic MRI for the surveillance of cystic neoplasms: comparison of a short with a comprehensive imaging protocol. European Radiology. ISSN 0938-7994. 27(1), p. 41–50. doi: 10.1007/s00330-016-4377-4.
• Haugvik, Sven-Petter; Kaemmerer, Daniel; Gaujoux, Sebastien; Labori, Knut Jørgen; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2016). Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape. Current Oncology Reports. ISSN 1523-3790. 18(5). doi: 10.1007/s11912-016-0518-9.
• Verbeke, Caroline Sophie (2016). Morphological heterogeneity in ductal adenocarcinoma of the pancreas - Does it matter? Pancreatology (Print). ISSN 1424-3903. 16(3), p. 295–301. doi: 10.1016/j.pan.2016.02.004.
• Del Chiaro, Marco; Verbeke, Caroline Sophie; Salvia, Roberto; Klöppel, Gunter; Werner, Jens & McKay, Colin [Show all 39 contributors for this article] (2013). European experts consensus statement on cystic tumours of the pancreas. Digestive and Liver Disease. ISSN 1590-8658. 45(9), p. 703–711. doi: 10.1016/j.dld.2013.01.010.
• Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2012). Resection margin involvement and tumour origin in pancreatic head cancer. British Journal of Surgery. ISSN 0007-1323. 99(8), p. 1036–1049. doi: 10.1002/bjs.8734.
• Verbeke, Caroline Sophie; Knapp, Johannes & Gladhaug, Ivar Prydz (2011). Tumour growth is more dispersed in pancreatic head cancers than in rectal cancer: implications for resection margin assessment. Histopathology. ISSN 0309-0167. 59(6), p. 1111–1121. doi: 10.1111/j.1365-2559.2011.04056.x.

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• Verbeke, Caroline Sophie & Campbell, Fiona M. (2021). Pathology of the pancreas. A practical approach. Springer London. ISBN 978-3-030-49847-4. 442 p.

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• Henmo, Ola; Helland, Åslaug; Mala, Tom; Verbeke, Caroline Sophie & Bjerkvig, Rolf (2023). Dette superteamet skal løse våre største kreftutfordringer. [Business/trade/industry journal]. Forskning.no.
• Schuurmans, Megan; Alves, Natália; Vendittelli, Pierpaolo; Huisman, Henkjan; Hermans, John & Litjens, Geert [Show all 10 contributors for this article] (2023). Artificial Intelligence in Pancreatic Ductal Adenocarcinoma Imaging: A Commentary on Potential Future Applications. Gastroenterology. ISSN 0016-5085. 165(2), p. 309–316. doi: 10.1053/j.gastro.2023.04.003.
• Resell, Mathilde Victoria; Rabben, Hanne-Line; Amrutkar, Manoj; Hagen, Lars; Batra, Surinder K. & Verbeke, Caroline Sophie [Show all 9 contributors for this article] (2023). Mo1138 COMPARATIVE PROTEOMICS REVEALS TRANSLATIONAL POTENTIAL OF TARGETS FOR PANCREATIC DUCTAL ADENOCARCINOMA. Gastroenterology. ISSN 0016-5085. 164(6), p. S-771–S-771.
• Resell, Mathilde Victoria; Rabben, Hanne-Line; Amrurkar, Manoj; Hagen, Lars; Batra, Surinder K. & Verbeke, Caroline Sophie [Show all 9 contributors for this article] (2023). COMPARATIVE PROTEOMICS REVEALS TRANSLATIONAL POTENTIAL OF TARGETS FOR PANCREATIC DUCTAL ADENOCARCINOMA.
• Arnelo, Urban; Rangelova, Elena; Del Chiaro, Marco; Valente, Roberto & Verbeke, Caroline Sophie (2019). RE: correct reporting is of utmost importance when a controversial treatment is being evaluated. HPB. ISSN 1365-182X. 21(9), p. 1251–1252. doi: 10.1016/j.hpb.2019.04.009.
• Del Chiaro, Marco; Arnelo, Urban; Rangelova, Elena; Valente, Roberto & Verbeke, Caroline Sophie (2019). RE: Pancreatectomy with arterial resection. HPB. ISSN 1365-182X. 21(9), p. 1254–1255. doi: 10.1016/j.hpb.2019.06.003.
• Kartalis, Nikolaos; Rinta-Kiikka, Irina; Wünsche, Katharina; Laukkarinen, Johanna; Labori, Knut Jørgen & Ånonsen, Kim Vidar [Show all 9 contributors for this article] (2015). Pancreatic MRI for the follow-up of cystic neoplasms: Comparison of a short with a comprehensive imaging protocol.
• Labori, Knut Jørgen; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2015). Information needs among patients and a surveillance strategy after surgery for pancreatic and periampullary cancer. HPB Surgery. ISSN 0894-8569. 17(7). doi: 10.1111/hpb.12411.

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