Glenny Cecilie Alfsen

• Eng, Hanna Maria; Ellingsen, Christian Lycke; Pedersen, Anne Gro & Alfsen, G. Cecilie (2023). Cause of death certificates in nursing homes: Does quality matter? A retrospective review from two counties in Norway. Scandinavian Journal of Public Health. ISSN 1403-4948. doi: 10.1177/14034948231187512. Full text in Research Archive
• Tahiri, Andliena; Puco, Katarina; Naji, Faris; Kristensen, Vessela N.; Alfsen, G. Cecilie & Farkas, Lorant [Show all 10 contributors for this article] (2022). Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors. OncoTarget. ISSN 1949-2553. 13(1), p. 970–981. doi: 10.18632/oncotarget.28257. Full text in Research Archive Show summary

  Kinase activity is frequently altered in renal cell carcinoma (RCC), and tyrosine kinase inhibitors (TKIs) are part of the standard treatment strategy in patients with metastatic disease. However, there are still no established biomarkers to predict clinical benefits of a specific TKI. Here, we performed protein tyrosine kinase (PTK) profiling using PamChip® technology. The aim of this study was to identify differences in PTK activity between normal and malignant kidney tissue obtained from the same patient, and to investigate the inhibitory effects of TKIs frequently used in the clinics: sunitinib, pazopanib, cabozantinib and tivozanib. Briefly, our results showed that 36 kinase substrates differs (FDR < 0.05) between normal and cancer kidney tissue, where members of the Src family kinases and the phosphoinositide-3-kinase (PI3K) pathway exhibit high activity in renal cancer. Furthermore, ex vivo treatment of clear cell RCC with TKIs revealed that pathways such as Rap1, Ras and PI3K pathways were strongly inhibited, whereas the neurotrophin pathway had increased activity upon TKI addition. In our assay, tivozanib and cabozantinib exhibited greater inhibitory effects on PTK activity compared to sunitinib and pazopanib, implying they might be better suitable as TKIs for selected RCC patients.

• Ellingsen, Christian Lycke; Alfsen, Glenny Cecilie; Ebbing, Marta; Pedersen, Anne Gro; Sulo, Gerhard & Vollset, Stein Emil [Show all 7 contributors for this article] (2022). Garbage codes in the Norwegian Cause of Death Registry 1996–2019. BMC Public Health. ISSN 1471-2458. 22. doi: 10.1186/s12889-022-13693-w. Full text in Research Archive Show summary

  Background: Reliable statistics on the underlying cause of death are essential for monitoring the health in a population. When there is insufficient information to identify the true underlying cause of death, the death will be classified using less informative codes, garbage codes. If many deaths are assigned a garbage code, the information value of the cause-of-death statistics is reduced. The aim of this study was to analyse the use of garbage codes in the Norwegian Cause of Death Registry (NCoDR). Methods: Data from NCoDR on all deaths among Norwegian residents in the years 1996–2019 were used to describe the occurrence of garbage codes. We used logistic regression analyses to identify determinants for the use of garbage codes. Possible explanatory factors were year of death, sex, age of death, place of death and whether an autopsy was performed. Results: A total of 29.0% (290,469/1,000,128) of the deaths were coded with a garbage code; 14.1% (140,804/1,000,128) with a major and 15.0% (149,665/1,000,128) with a minor garbage code. The five most common major garbage codes overall were ICD-10 codes I50 (heart failure), R96 (sudden death), R54 (senility), X59 (exposure to unspecified factor), and A41 (other sepsis). The most prevalent minor garbage codes were I64 (unspecified stroke), J18 (unspecified pneumonia), C80 (malignant neoplasm with unknown primary site), E14 (unspecified diabetes mellitus), and I69 (sequelae of cerebrovascular disease). The most important determinants for the use of garbage codes were the age of the deceased (OR 17.4 for age ≥ 90 vs age

• Alfsen, G. Cecilie; Braut, Geir Sverre & Ellingsen, Christian Lycke (2022). En nasjonal strategi for obduksjoner mangler. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(8). doi: 10.4045/tidsskr.22.0061.
• Alfsen, G. Cecilie; Gulczyński, Jacek; Kholová, Ivana; Latten, Bart; Martínez, Javier & Metzger, Myriam [Show all 13 contributors for this article] (2021). Code of practice for medical autopsies: A minimum standard position paper for pathology departments performing medical (hospital) autopsies in adults . Virchows Archiv. ISSN 0945-6317. doi: 10.1007/s00428-021-03242-y. Full text in Research Archive
• Eng, Hanna Maria; Bie, Rolf Bruun; Skjulsvik, Anne Jarstein; Pedersen, Anne Gro & Alfsen, G. Cecilie (2021). Kvaliteten på medisinske obduksjonsrapporter. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(11), p. 1–5. doi: 10.4045/tidsskr.20.1000. Full text in Research Archive
• Ellingsen, Christian Lycke; Alfsen, G. Cecilie & Braut, Geir Sverre (2021). Forensic autopsies in Norway 1996–2017: A retrospective study of factors associated with deaths undergoing forensic autopsy. Scandinavian Journal of Public Health. ISSN 1403-4948. doi: 10.1177/1403494821997208. Full text in Research Archive
• Ellingsen, Christian Lycke; Ebbing, Marta; Alfsen, G. Cecilie & Vollset, Stein Emil (2018). Injury death certificates without specification of the circumstances leading to the fatal injury - the Norwegian Cause of Death Registry 2005-2014. Population Health Metrics. ISSN 1478-7954. 16. doi: 10.1186/s12963-018-0176-2. Full text in Research Archive
• Alfsen, G. Cecilie; Chen, Ying; Kähler, Hanne & Bukholm, Ida Rashida Khan (2016). Pathology-related cases in the Norwegian System of Patient Injury Compensation in the period 2010–2015. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(23-24), p. 1984–1987. doi: 10.4045/tidsskr.16.0435.
• Alfsen, G. Cecilie & Hernæs, Lotte (2013). Døde spedbarn og ugifte kvinner - fra rettsmedisinske erklæringer 1910-12. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 133(23-24), p. 2493–2497. doi: 10.4045/tidsskr.13.0897.
• Alfsen, G. Cecilie & Hernæs, Lotte (2013). Dead infants and unmarried women - from forensic pathology reports 1910-12. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 133(23), p. 2493–2497.
• Alfsen, G. Cecilie (2013). Medical autopsies after deaths outside hospital. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 7(133), p. 756–759. doi: 10.4045/tidsskr.12.1081.
• Alfsen, G. Cecilie & Lyckander, Lars Gustav (2013). Does quality control of death certificates in hospitals have an impact on cause of death statistics? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 7(133), p. 750–755. doi: 10.4045/tidsskr.12.0943.
• Tropé, Ameli Ellen Claesdotter; Sjøborg, Katrine Dønvold; Nygård, Mari; Røysland, Kjetil; Campbell, Suzanne & Alfsen, Glenny Cecilie [Show all 7 contributors for this article] (2012). Cytology and Human Papillomavirus Testing 6 to 12 Months after ASCUS or LSIL Cytology in Organized Screening To Predict High-Grade Cervical Neoplasia between Screening Rounds. Journal of Clinical Microbiology. ISSN 0095-1137. 50(6), p. 1927–1935. doi: 10.1128/JCM.00265-12.
• Alfsen, Glenny Cecilie & Mæhlen, Jan (2012). Obduksjonens betydning for registrering av dødsårsak. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 132(2), p. 147–151. doi: 10.4045/tidsskr.11.0427.
• Tropé, Ameli Ellen Claesdotter; Jonassen, Christine M; Sjøborg, Katrine Dønvold; Nygård, Mari; Dahl, Fredrik Andreas & Alfsen, Glenny Cecilie [Show all 7 contributors for this article] (2011). Role of high-risk human papillomavirus (HPV) mRNA testing in the prediction of residual disease after conisation for high-grade cervical intraepithelial neoplasia. Gynecologic Oncology. ISSN 0090-8258. 123(2), p. 257–262. doi: 10.1016/j.ygyno.2011.07.032.
• Alfsen, Glenny Cecilie; Lyckander, Lars Gustav; LINDBOE, ANNE & Svaar, Helge (2010). Kvalitetssikring ved dødsfall i sykehus. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(5), p. 476–479.
• Axcrona, Karol; Brennhovd, Bjørn; Alfsen, G. Cecilie; Giercksky, Karl-Erik & Warloe, Trond (2007). Photodynamic therapy With methyl aminolevulinate for atypical carcinoma in situ of the penis. Scandinavian Journal of Urology and Nephrology. ISSN 0036-5599. 41, p. 507–510.
• Alfsen, Cecilie G.; Reed, Wenche; Sandstad, Berit; Kristensen, Gunnar B. & Abeler, Vera M (2003). The prognostic impact of the cyclin-dependent kinase inhibitors p21WAF1, P27Kip1 and p16INK4/MTS1 in adenocarcinomas of the uterine cervix. An immunohistochemical evaluation of expression patterns in a population based material from 142 patients in FIGO Stage I and II. Cancer. ISSN 0008-543X. 98, p. 1880–1889.
• Alfsen, Cecilie G.; Reed, Wenche & Abeler, Vera M (2003). Reproducibility of calissification in non-squamous cell carcinomas of the uterine cervix. Gynecologic Oncology. ISSN 0090-8258. 90(2), p. 282–289.
• Oldenburg, Jan; Alfsen, G. Cecilie; Lien, Hans Henrik; Aas, Nina; Wæhre, Haakon & Fosså, Sophie Dorothea (2003). Postchemotherapy retroperitoneal surgery remains necessary in patients with nonseminomatous testicular cancer and minimal residual tumour masses. Journal of Clinical Oncology. ISSN 0732-183X. 21, p. 3310–3317.
• Alfsen, Cecilie G.; Kristensen, Gunnar B.; Skovlund, Eva; Pettersen, Erik O & Abeler, Vera M (2001). Histologic subtype has minor importance for overall survival in patients with adenocarcinoma of the uterine cervix. Cancer. ISSN 0008-543X. 92(9), p. 2471–2483. Show summary

  A poulation-based study of prognostic factors in 505 patients with nonsquamous cell carcinomas of the cervix.

• Alfsen, G. Cecilie; Thoresen, Steinar Østerbø; Kristensen, Gunnar S Balle; Skovlund, Eva & Abeler, Vera Maria (2000). Histopathologic subtyping of cervical adenocarcinomas reveals increasing incidence rates of endometrioid tumors in all age Groups: a population based study With review of all nonsquamous cervical carcinomas in Norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990. Cancer. ISSN 0008-543X. 89, p. 1291–1299.
• Bryne, Magne; Boysen, Morten Ebbe; Alfsen, Cecilie G.; Abeler, Vera M; Sudbø, Jon & Nesland, Jahn M [Show all 7 contributors for this article] (1998). The invsive front of carcinomas. The most important area for tumour prognostication. Antivancer. 18(5).
• Bryne, Magne; Boysen, Morten Ebbe; Alfsen, Cecilie G.; Abeler, Vera M; Sudbø, Jon & Nesland, Jahn M [Show all 9 contributors for this article] (1998). The Invasive Front of Carcinomas. The Most Important Area for Tumour Prognosis? Anticancer Research. ISSN 0250-7005. 18, p. 4757–4764.
• Scheistrøen, M.; Trope, Claes Gøran; Kærn, Janne; Pettersen, Eirik; Alfsen, Cecilie G. & Nesland, Jahn M (1997). DNA Ploidy and Express of p53 and C-erbB-2 in Extramammary Paget's Disease of the Vulva. Gynecologic Oncology. ISSN 0090-8258. 64, p. 88–92.

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• Akslen, Lars Andreas; Alfsen, G. Cecilie & Chen, Ying (2023). Faget og foreningen gjennom 100 år. Den Norske Patologforening 1923-2023. . Den norske patologforening. ISBN 978-82-91613-15-4. 446 p.

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• Hansen, Mona; Kristiansen-Haugland, Hanne; Ambur, Ole Herman; Christiansen, Irene Kraus & Alfsen, G. Cecilie (2017). Prevalence of human papillomavirus in tonsillar/adenoid tissue. A study of paraffin-embedded archival material from diagnostic biobanks in Norway.
• Kristiansen-Haugland, Hanne; Hansen, Mona; Penz, Carla; Ambur, Ole Herman; Alfsen, G. Cecilie & Christiansen, Irene Kraus (2017). Validation of HPV analysis of formalin-fixed paraffin-embedded tissue; procedures to be included in long-term HPV vaccine surveillance in Norway.
• Alfsen, G. Cecilie; Herns, L. & Ellingsen, Christian Lycke (2013). Infanticide or stillbirth? Forensic pathology in Norway 100 years ago. Virchows Archiv. ISSN 0945-6317. 463(2), p. 223–223.
• Alfsen, Glenny Cecilie; Ellingsen, Christian Lycke & Hernæs, Lotte (2013). «Barnet har levet og aandet» – sakkyndighet ved døde nyfødte 1910 – 12. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 133, p. 2498–2501. doi: 10.4045/tidsskr.13.0898.
• Alfsen, Glenny Cecilie (2010). Tenk på et tall! Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(16).
• Hansen, Mona; Alfsen, Glenny Cecilie & Jonassen, Christine M. (2010). Lasermicrodissection and Real-Time RT-PCR in a Study of HPV Oncogene Expression in Cervical Intraepithelial Neoplasia and Cancer.
• Alfsen, G. Cecilie (2010). Ja, vi trenger flere obduksjoner! Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(11).
• Alfsen, Cecilie G.; Abeler, Vera M; Reed, Wenche; Kristensen, Gunnar B.; Skovlund, Eva & Pettersen, Erik O [Show all 7 contributors for this article] (2000). Adenocarcinoma of the Uterine cervix. Incidence, Prognosis and Reproducibility of classification.
• Nilsen, Ellen M; Alfsen, Cecilie G.; Feiring, Berit; Skjeldestad, Finn Egil; Steen, Rita & Sæterdal, Ingvil von Mehren (2007). Prophylactic vaccines against human papillomavirus. Nasjonalt kunnskapssenter for helsetjenesten. ISSN 978-82-8121-145-2. Full text in Research Archive Show summary

  The Norwegian Knowledge Centre for the Health Service (NOKC) was requested by the Norwegian Institute of Public Health to do a health technology assessment (HTA) on the effectiveness of prophylactic vaccines against human papillomavirus (HPV) infection. This part of the report, has evaluated the effectiveness and safety of such vaccines. Part two evaluates the cost-effectiveness and will be published at a later stage.

• Alfsen, Cecilie (2004). Adenocarcinomas and other non-squamous cell carcinomas of the uterine cervix. A population-based study. Unipub forlag. ISSN 82-8072-106-1.

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