Ellen Jørum

• Lunden, Lars Kristian; Kleggetveit, Inge Petter; Schmelz, Martin & Jørum, Ellen (2022). Cold allodynia is correlated to paroxysmal and evoked mechanical pain in complex regional pain syndrome (CRPS). Scandinavian Journal of Pain. ISSN 1877-8860. 22(3), p. 533–542. doi: 10.1515/sjpain-2021-0208. Full text in Research Archive
• Lunden, Lars Kristian & Jorum, Ellen (2021). The challenge of recognizing severe pain and autonomic abnormalities for early diagnosis of CRPS. Scandinavian Journal of Pain. ISSN 1877-8860. 21(3), p. 548–559. doi: 10.1515/sjpain-2021-0036. Full text in Research Archive
• Rukwied, Roman; Thomas, Christian; Obreja, Otilia; Werland, Fiona; Kleggetveit, Inge Petter & Jørum, Ellen [Show all 9 contributors for this article] (2020). Slow depolarizing stimuli differentially activate mechanosensitive and silent C nociceptors in human and pig skin. Pain. ISSN 0304-3959. 161(9), p. 2119–2128. doi: 10.1097/j.pain.0000000000001912.
• Werland, Fiona; Hirth, Michael; Rukwied, Roman; Ringkamp, Matthias; Turnquist, Brian & Jørum, Ellen [Show all 9 contributors for this article] (2020). Maximum axonal following frequency separates classes of cutaneous unmyelinated nociceptors in the pig. Journal of Physiology. ISSN 0022-3751. doi: 10.1113/JP280269. Full text in Research Archive
• Namer, Barbara; Schmidt, Diana; Eberhardt, Esther; Maroni, Michele; Dorfmeister, Eva & Kleggetveit, Inge Petter [Show all 19 contributors for this article] (2019). Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors. EBioMedicine. ISSN 2352-3964. 39, p. 401–408. doi: 10.1016/j.ebiom.2018.11.042.
• Dukefoss, Tore Thomas; Kleggetveit, Inge Petter; Helås, Tormod & Jørum, Ellen (2019). Pain and small-fiber affection in hereditary neuropathy with liability to pressure palsies (HNPP). Scandinavian Journal of Pain. ISSN 1877-8860. 20(1), p. 61–68. doi: 10.1515/sjpain-2019-0090. Show summary

  Abstract Background and aims Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal – dominant hereditary neuropathy caused by a deficiency in the peripheral protein PMP-22, due to deletion on chromosome 17p11,2 or in some rare cases point mutations in the PMP-22 gene. The clinical picture is characterized by recurrent mononeuropathies in nerves which frequently may be exposed to pressure, such as the median, ulnar, radial and peroneal nerves or also a more general neuropathy. Although pain is reported to be an unusual clinical symptom, there have been reports of pain in a surprisingly high proportion of these patients. Since pain may be explained by mechanisms in afferent small unmyelinated C- nerve fibers, an assessment of the function of small nerve fibers has been requested. The purpose of the present study was to investigate the presence of pain and the possible affection of afferent small nerve-fibers, A-δ and C-fibers, by quantitative sensory testing (QST)-assessment of thermal thresholds, as well as quantitative sudomotor axon reflex (QSART), a quantitative, validated assessment of efferent postganglionic sumodotor function. QST values were compared to values of age- and sex matched healthy subjects. Methods The 19 patients were investigated clinically, with an emphasis on pain characteristics, with nerve conduction studies (NCS) of major nerves in upper- and lower extremity, small fiber testing (QST, measurement of thermal thresholds) and with QSART. Results A total of 10 patients reported numbness in some extremity, suggesting entrapment of individual nerves as well as a general neuropathy, as verified by NCS in nine patients. A total of 15 patients had findings compatible with a general polyneuropathy. A total of eight patients reported pain, seven patients with pain in the feet, described as burning, aching, shooting and six with severe pathological QST values, mainly cold detection, but also four patients with elevated thresholds to warmth. Four of the patients had signs of a severe sensory neuropathy on NCS, with no sural findings. One patient had only pain in the arms, with only minor changes on NCS and with normal QST-values. Cold detection thresholds (CD) were significantly elevated (reduced sensibility) on the dorsum of the foot (mean of two feet), in patients [26.0 °C (19.7–28.0)] as compared with healthy subjects [28.6 °C (27.4–29.6) p = 0.000]. There were also significantly elevated warmth detection thresholds (WD) in feet in patients 39.5 °C (36.4–42.9) compared to healthy subjects [37.7 °C (36.1–39.4) p = 0.048]. However, there were no significant differences in QST values between patients with and without pain. Conclusions Of a total of 19 patients with verified HNPP, eight patients (42.1%) suffered from neuropathic pain, mainly in both feet. Implications Due to the high percentage of pain in HNPP, it is important not to disregard this diagnosis in a patient presenting with pain. Since there are no significant differences in QST values in patients with and without pain, routine QST studies in HNPP do not seem necessary. Keywords: hereditary neuropathy with liability to pressure palsies (HNPP); pain; nerve conduction studies; small fiber affection; quantitative sensory testing

• Jørum, Ellen & Opstad, Per Kristian (2019). A 4-year follow-up of non-freezing cold injury with cold allodynia and neuropathy in 26 naval soldiers. Scandinavian Journal of Pain. ISSN 1877-8860. 19(3), p. 441–451. doi: 10.1515/sjpain-2019-0035.
• Meents, Jannis E.; Bressan, Elisangela; Sontag, Stephanie; Foerster, Alec; Hautvast, Petra & Rösseler, Corinna [Show all 23 contributors for this article] (2019). The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients. Pain. ISSN 0304-3959. 160(6), p. 1327–1341. doi: 10.1097/j.pain.0000000000001511. Full text in Research Archive
• Kleggetveit, Inge Petter & Jørum, Ellen (2018). Diagnosis of carpal tunnel syndrome. Scandinavian Journal of Pain. ISSN 1877-8860. 18(3), p. 333–337. doi: 10.1515/sjpain-2018-0089.
• Helås, Tormod; Sagafos, Dagrun; Kleggetveit, Inge Petter; Quiding, Hans; Jönsson, B. & Segerdahl, Märta [Show all 10 contributors for this article] (2017). Pain thresholds, supra-threshold pain and lidocaine sensitivity in patients with erythromelalgia, including the I848Tmutation in NaV 1.7. European Journal of Pain. ISSN 1090-3801. 21(8), p. 1316–1325. doi: 10.1002/ejp.1030.
• Namer, Barbara; Ørstavik, Kristin; Schmidt, Roland; Mair, Norbert; Kleggetveit, Inge Petter & Zeidler, Maximillian [Show all 12 contributors for this article] (2017). Changes in ionic conductance signature of nociceptive neurons underlying fabry disease phenotype. Frontiers in Neurology. ISSN 1664-2295. 8:335, p. 1–18. doi: 10.3389/fneur.2017.00335.
• Kleggetveit, Inge Petter; Schmidt, Roland; Namer, Barbara; Salter, Hugh; Helås, Tormod & Schmelz, Martin [Show all 7 contributors for this article] (2016). Pathological nociceptors in two patients with erythromelalgia-like symptoms and rare genetic Nav 1.9 variants. Brain and Behavior. ISSN 2162-3279. 6(10). doi: 10.1002/brb3.528.
• Kist, Andreas M.; Sagafos, Dagrun; Rush, Anthony M.; Neacsu, Cristian; Eberhardt, Esther & Schmidt, Roland [Show all 21 contributors for this article] (2016). SCN10A mutation in a patient with erythromelalgia enhances C-fiber activity dependent slowing. PLOS ONE. ISSN 1932-6203. 11(9). doi: 10.1371/journal.pone.0161789.
• Lunden, Lars Kristian; Kleggetveit, Inge Petter & Jørum, Ellen (2016). Delayed diagnosis and worsening of pain following orthopedic surgery in patients with complex regional pain syndrome (CRPS). Scandinavian Journal of Pain. ISSN 1877-8860. 11, p. 27–33. doi: 10.1016/j.sjpain.2015.11.004.
• Sagafos, Dagrun; Kleggetveit, Inge Petter; Helås, Tormod; Schmidt, Roland; Minde, Jan & Namer, Barbara [Show all 8 contributors for this article] (2016). Single-fiber recordings of nociceptive fibers in patients With HSAN type 5 With congenital insensitivity to pain. The Clinical Journal of Pain. ISSN 0749-8047. 32(7), p. 636–642. doi: 10.1097/AJP.0000000000000303.
• Jørum, Ellen (2016). Solkongens analfistel. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(14), p. 1244–1247. doi: 10.4045/tidsskr.15.0312.
• Horn, Morten Andreas; Müller, Karin Brigitte; Ferdinandusse, Sacha; Jørum, Ellen; Mellgren, Svein Ivar & Retterstøl, Lars [Show all 8 contributors for this article] (2016). Mild phenotype in an adult male with X‐linked adrenoleukodystrophy – case report. Clinical Case Reports. ISSN 2050-0904. 4(2), p. 177–181. doi: 10.1002/ccr3.434. Full text in Research Archive
• Jørum, Ellen (2016). Advancing Methods for characterizing structure and functions of small nerve fibers in neuropathic conditions. Scandinavian Journal of Pain. ISSN 1877-8860. 10, p. 54–56. doi: 10.1016/j.sjpain.2015.09.005.
• Kleggetveit, Inge Petter; Skulberg, Per Kristian & Jørum, Ellen (2016). Complex regional pain syndrome following viper-bite. Scandinavian Journal of Pain. ISSN 1877-8860. 10, p. 15–18. doi: 10.1016/j.sjpain.2015.07.005.
• Namer, B.; Ørstavik, Kristin; Schmidt, R; Kleggetveit, Inge Petter; Weidner, Christian & Mørk, Cato [Show all 17 contributors for this article] (2015). Specific changes in conduction velocity recovery cycles of single nociceptors in a patient With erythromelalgia With the l848T gain of function mutation of Nav1.7. Pain. ISSN 0304-3959. 156(9), p. 1637–1646. doi: 10.1097/j.pain.0000000000000229. Show summary

  Seven patients diagnosed with erythromelalgia (EM) were investigated by microneurography to record from unmyelinated nerve fibers in the peroneal nerve. Two patients had characterized variants of sodium channel Nav1.7 (I848T, I228M), whereas no mutations of coding regions of Navs were found in 5 patients with EM. Irrespective of Nav1.7 mutations, more than 50% of the silent nociceptors in the patients with EM showed spontaneous activity. In the patient with mutation I848T, all nociceptors, but not sympathetic efferents, displayed enhanced early subnormal conduction in the velocity recovery cycles and the expected late subnormality was reversed to supranormal conduction. The larger hyperpolarizing shift of activation might explain the difference to the I228M mutation. Sympathetic fibers that lack Nav1.8 did not show supranormal conduction in the patient carrying the I848T mutation, confirming in human subjects that the presence of Nav1.8 crucially modulates conduction in cells expressing EM mutant channels. The characteristic pattern of changes in conduction velocity observed in the patient with the I848T gain-of function mutation in Nav1.7 could be explained by axonal depolarization and concomitant inactivation of Nav1.7. If this were true, activity-dependent hyperpolarization would reverse inactivation of Nav1.7 and account for the supranormal CV. This mechanism might explain normal pain thresholds under resting conditions.

• Namer, Barbara; Schick, Maximilian; Kleggetveit, Inge Petter; Ørstavik, Kristin; Schmidt, Roland & Jørum, Ellen [Show all 9 contributors for this article] (2015). Differential sensitization of silent nociceptors to low pH stimulation by prostaglandin E2 in human volunteers. European Journal of Pain. ISSN 1090-3801. 19(2), p. 159–166. doi: 10.1002/ejp.532.
• Zhang, Zhiping; Schmelz, Martin; Segerdahl, Märta; Quiding, Hans; Centerholt, Carina & Juréus, Anna [Show all 15 contributors for this article] (2014). Exonic mutations in SCN9A (Na<sub>V</sub>1.7) are found in a minority of patients with erythromelalgia. Scandinavian Journal of Pain. ISSN 1877-8860. 5(4), p. 217–225. doi: 10.1016/j.sjpain.2014.09.002.
• Horn, Morten Andreas; Nilsen, Kristian Bernhard; Jørum, Ellen; Mellgren, Svein Ivar & Tallaksen, Chantal (2014). Small nerve fiber involvement is frequent in X-linked adrenoleukodystrophy. Neurology. ISSN 0028-3878. 82(19), p. 1678–1683. doi: 10.1212/WNL.0000000000000415.
• Ørstavik, Kristin; Kleggetveit, Inge Petter & Jørum, Ellen (2013). Mikronevrografi og forskning på perifer nevropatisk smerte. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 133(3), p. 302–305. doi: 10.4045/tidsskr.12.0098.
• Haugaa, Kristina; Andersson, Stein; Vestervik, Tommy Tveit; Amlie, Jan Peder; Jørum, Ellen & Gjerstad, Leif [Show all 7 contributors for this article] (2013). Abnormal electroencephalograms in patients with long QT syndrome. Heart Rhythm. ISSN 1547-5271. 10(12), p. 1877–1883. doi: 10.1016/j.hrthm.2013.09.070.
• Sveen, Kari Anne; Karimé, Bassam; Jørum, Ellen; Mellgren, Svein Ivar; Fagerland, Morten & Monnier, Vincent [Show all 8 contributors for this article] (2013). Small- and large-fiber neuropathy after 40 years of type 1 diabetes associations with glycemic control and advanced protein glycation: the Oslo Study. Diabetes Care. ISSN 0149-5992. 36(11), p. 3712–3717. doi: 10.2337/dc13-0788. Full text in Research Archive
• Jørum, Ellen; Torbergsen, Torberg & Dietrichs, Espen (2013). Combined testing of autonomic and sensory dysfunction in patients with unilateral facial flushing and sweating during exercise. Neurophysiologie clinique. ISSN 0987-7053. 43(1), p. 1–10. doi: 10.1016/j.neucli.2012.09.090.
• Kleggetveit, Inge Petter; Namer, Barbara; Schmidt, Roland; Helås, Tormod; Ruckel, Michael & Ørstavik, Kristin [Show all 8 contributors for this article] (2012). High spontaneous activity of C-nociceptors in painful polyneuropathy. Pain. ISSN 0304-3959. 153(10), p. 2040–2047. doi: 10.1016/j.pain.2012.05.017.
• Schmidt, Roland; Kleggetveit, Inge Petter; Namer, Barbara; Helås, Tormod; Obreja, Otilia & Schmelz, Martin [Show all 7 contributors for this article] (2012). Double spikes to single electrical stimulation correlates to spontaneous activity of nociceptors in painful neuropathy patients. Pain. ISSN 0304-3959. 153(2), p. 391–398. doi: 10.1016/j.pain.2011.10.041.
• Kankel, Jennifer; Obreja, Otilia; Kleggetveit, Inge Petter; Schmidt, Roland; Jørum, Ellen & Schmelz, Martin [Show all 7 contributors for this article] (2012). Differential Effects of Low Dose Lidocaine on C-Fiber Classes in Humans. Journal of Pain. ISSN 1526-5900. 13(12), p. 1232–1241. doi: 10.1016/j.jpain.2012.09.008.
• Ørstavik, Kristin & Jørum, Ellen (2010). Microneurographic findings of relevance to pain in patients with erythromelalgia and patients with diabetic neuropathy. Neuroscience Letters. ISSN 0304-3940. 470(3), p. 180–184. doi: 10.1016/j.neulet.2009.05.061.
• Kleggetveit, Inge Petter & Jørum, Ellen (2010). Large and Small Fiber Dysfunction in Peripheral Nerve Injuries With or Without Spontaneous Pain. Journal of Pain. ISSN 1526-5900. 11(12), p. 1305–1310. doi: 10.1016/j.jpain.2010.03.004.
• Sand, Trond & Jørum, Ellen (2010). Klinisk nevrofysiologi. In Gjerstad, Leif; Helseth, Eirik & Rootwelt, Terje (Ed.), Nevrologi og nevrokirurgi. Fra barn til voksen. 5.utgave. Forlaget Vett & Viten AS. ISSN 978-82-412-0686-3. p. 75–97.
• Koht, Jeanette Aimee; Bjornara, KA; Jørum, Ellen & Tallaksen, Chantal (2009). Ataxia with vitamin E deficiency in southeast Norway, case report. Acta Neurologica Scandinavica. ISSN 0001-6314. 120, p. 42–45.
• Eide, Per Kristian; Sorteberg, Wilhelm; Meling, Torstein Ragnar; Jørum, Ellen; Hald, John K & Stubhaug, Audun (2007). From intracranial pressure to intracranial pressure wave-guided intensive care management of a patient with an aneurysmal subarachnoid hemorrhage. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 51(4), p. 501–504.
• Cruccu, G; Anand, P; Attal, N; Garcia-Larrea, L; Haanpää, M & Jørum, Ellen [Show all 8 contributors for this article] (2004). EFNS guidelines on neuropathic pain assessment. European Journal of Neurology. ISSN 1351-5101. 11, p. 153–162.
• Ørstavik, Kristin; Mørk, Cato; Kvernebo, Knut & Jørum, Ellen (2004). Pain in primary erythromelalgia - a neuropathic component. Pain. ISSN 0304-3959. 110(3), p. 531–538.
• Eide, Per Kristian; Jørum, Ellen; Stubhaug, Audun; Bremnes, Jørn & Breivik, Harald (1994). Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo . Pain. ISSN 0304-3959. 58(3), p. 347–354.

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• Handwerker, Hermann; Jørum, Ellen; Schady, Wolfgang; LaMotte, Robert & Schmelz, Martin (2022). Erik Torebjörk, MD PhD, Professor of Clinical Pain Research 1939-2021 Forerunner and lead researcher of human nociceptor research. European Journal of Pain. ISSN 1090-3801. 26(2), p. 275–279. doi: 10.1002/ejp.1893.
• Norheim, Arne Johan; Rannestad, Bård Stian; Howes, Richard; Rein, Erling Bekkestad; Jørum, Ellen & Friedl, Karl [Show all 16 contributors for this article] (2022). Abstracts from The Cold Weather Operations Conference 2021. International Journal of Circumpolar Health. ISSN 1239-9736. 81(1). doi: 10.1080/22423982.2022.2049491. Full text in Research Archive Show summary

  A common effort for both military and civil healthcare is to achieve knowledge-based health care in cold weather injuries and fatal accidents in harsh arctic environment. The Cold Weather Operations Conference in November 2021, having more than 300 participants from 20 countries, was addressing the prevention and treatment of injuries and trauma care in cold weather conditions and the challenges for military prehospital casualty care. The intention of the programme was to stimulate further research and systematic knowledge-based clinical work. The abstracts from the conference present cold weather research and clinical experience relevant for readers of the International Journal of Circumpolar Health.

• Kleggetveit, Inge Petter & Jørum, Ellen (2018). Reply to the Letter to the Editor by Ly-Pen and Andreu. Scandinavian Journal of Pain. ISSN 1877-8860. 18(4). doi: 10.1515/sjpain-2018-0118.
• Sand, Trond & Jørum, Ellen (2014). Klinisk nevrofysiologi (KNF), Nevrologi og nevrokirurgi fra barn til voksen, 6.utgave. Forlaget Vett & Viten AS. ISSN 978-82-412-0709-9. p. 75–98.
• Hals, Else Kristine Breivik; Herlofson, Bente Brokstad; Breivik, Harald; Jørum, Ellen; Mellgren, Svein Ivar & Stubhaug, Audun (2011). Intraoral somatosensory function in patients with chronic orofacial pain.
• Jørum, Ellen; Ørstavik, Kristin; Schmidt, Roland; Carr, Richard W.; Kvarstein, Gunnvald & Hilliges, Marita [Show all 9 contributors for this article] (2007). Catecholamine-induced excitation of nociceptors in sympathetically maintained pain. Pain. ISSN 0304-3959. 127(3). doi: 10.1016/j.pain.2006.08.022.
• Jørum, Ellen (2004). Neuropathic pain; assessment and treatment. Pfizer.

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