Erik Harald Øie

• Berg, Erlend; Tegn, Nicolai Kloumann; Abdelnoor, Michael; Røysland, Kjetil; Ryalen, Pål Christie & Aaberge, Lars [Show all 14 contributors for this article] (2023). Long-Term Outcomes of Invasive vs Conservative Strategies for Older Patients With Non–ST-Segment Elevation Acute Coronary Syndromes. Journal of the American College of Cardiology. ISSN 0735-1097. 82(21), p. 2021–2030. doi: 10.1016/j.jacc.2023.09.809. Full text in Research Archive
• Schwartz, Thomas; Hoornstra, Dieuwertje; Øie, Erik Harald; Hovius, Joppe & Quarsten, Hanne (2023). Case report: First case of Borrelia miyamotoi meningitis in an immunocompromised patient in Norway. IDCases. ISSN 2214-2509. 33. doi: 10.1016/j.idcr.2023.e01867.
• Sørensen, Eivind; Myrstad, Marius; Solberg, Magnar Gangås; Øie, Erik; Platonov, Pyotr G. & Carlson, Jonas [Show all 8 contributors for this article] (2023). Left atrial dyssynchrony in veteran endurance athletes with and without paroxysmal atrial fibrillation. Echocardiography. ISSN 0742-2822. doi: 10.1111/echo.15634. Full text in Research Archive
• Kolden, Mathias Øie; Nymo, Ståle Haugset & Øie, Erik (2022). Impact of neighbourhood-level socioeconomic status, traditional coronary risk factors, and ancestry on age at myocardial infarction onset: A population-based register study. BMC Cardiovascular Disorders. ISSN 1471-2261. 22(1). doi: 10.1186/s12872-022-02880-7.
• Nymoen, Lisbeth Damlien; Flatebø, Trude Eline; Moger, Tron Anders; Øie, Erik; Molden, Espen & Viktil, Kirsten Kilvik (2022). Impact of systematic medication review in emergency department on patients’ postdischarge outcomes—A randomized controlled clinical trial. PLOS ONE. ISSN 1932-6203. 17:e0274907(9), p. 1–19. doi: 10.1371/journal.pone.0274907. Full text in Research Archive
• Sørensen, Eivind; Myrstad, Marius; Solberg, Magnar Gangås; Øie, Erik; Tveit, Arnljot & Aarønæs, Marit (2022). Right Heart Structure and Function in Lifelong Recreational Endurance Athletes with and without Paroxysmal Atrial Fibrillation. Journal of the American Society of Echocardiography. ISSN 0894-7317. doi: 10.1016/j.echo.2022.06.008.
• Nymoen, Lisbeth Damlien; Björk, Malin; Flatebø, Trude Eline; Nilsen, Merethe; Godø, Aasmund & Øie, Erik [Show all 7 contributors for this article] (2022). Drug-related emergency department visits: prevalence and risk factors. Internal and Emergency Medicine. ISSN 1828-0447. doi: 10.1007/s11739-022-02935-9.
• Sørensen, Eivind; Myrstad, Marius; Solberg, Magnar Gangås; Øie, Erik; Tveit, Arnljot & Aarønæs, Marit (2021). Left atrial function in male veteran endurance athletes with paroxysmal atrial fibrillation. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 23(1), p. 137–146. doi: 10.1093/ehjci/jeab248. Full text in Research Archive
• Nymoen, Lisbeth Damlien; Tran, Therese Thanh Tu; Walter, Scott R; Lehnbom, Elin; Tunestveit, Ingrid Kinne & Øie, Erik [Show all 7 contributors for this article] (2021). Emergency department physicians' distribution of time in the fast paced-workflow-a novel time-motion study of drug-related activities. International Journal of Clinical Pharmacy. ISSN 2210-7703. doi: 10.1007/s11096-021-01364-6. Full text in Research Archive
• Børretzen, Mari Naumann; Romarheim, Synnøve Andrea; Danielsen, Tore Kristian; Leren, Ida Skrinde & Øie, Erik (2020). Infeksiøs endokarditt - egne data og internasjonale anbefalinger. . Hjerteforum. ISSN 0802-1465. 33(4), p. 19–30.
• Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman Ul-Haq; Muriq, Hysen & Fosshaug, Linn Elisabeth Lillerud [Show all 8 contributors for this article] (2020). Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study. European Journal of Clinical Pharmacology. ISSN 0031-6970. 76, p. 673–683. doi: 10.1007/s00228-020-02832-0. Full text in Research Archive Show summary

  Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the impact of CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction (MI). Methods We included 136 patients with MI discharged on treatment with metoprolol with a recommendation to the general practitioner (GP) to increase the metoprolol dose up to 200 mg/day within 2 months if possible. At follow-up, metoprolol dosage after up-titration, metoprolol steady-state trough plasma concentrations, hemodynamic parameters, potential metoprolol-induced adverse drug reactions and number of visits to the GP were measured. CYP2D6 genotyping including the reduced-function variant alleles CYP2D6*9, CYP2D6*10 and CYP2D6*41 was performed after end of follow-up. Results According to the genotype-defined CYP2D6 phenotypes, 30% of the patients were metoprolol extensive metabolizers (EMs), 55% intermediate metabolizers (IMs) and 13% poor metabolizers (PMs; carriers of non-coding and reduced-function variant included). Dose-adjusted metoprolol trough concentrations were significantly higher in IM (2-fold) and PM (6.2-fold) groups vs. the EM group (p < 0.001). Only 35% of patients in the PM group achieved the primary end point, i.e. reaching at least 85% of the expected maximum heart rate (HR) during exercise, compared with 78% in the EM group (p < 0.01), and maximum observed HR at exercise was significantly lower in the PM group vs. the EM group (129 ± 5 vs. 142 ± 2 bpm, p < 0.007). In contrast, metoprolol maintenance dose, blood pressure, exercise capacity, number of visits at the GP and frequency and severity of self-reported potential metoprolol-related adverse drug reactions were not significantly different between the groups. Conclusion Using a comprehensive CYP2D6 genotyping panel, the present study demonstrates a > 6-fold increase of dose-adjusted plasma metoprolol trough concentration in CYP2D6 PMs vs. EMs with a parallel lower increase in achieved maximum HR during exercise but without association between genotype and frequency or severity of self-reported adverse drug effects. This may indicate that CYP2D6 PMs potentially could benefit of the increased plasma concentration per dose in a naturalistic setting.

• Tazmini, Kiarash; Fraz, Mai; Nymo, Ståle Haugset; Stokke, Mathis Korseberg; Louch, William Edward & Øie, Erik (2020). Potassium infusion increases the likelihood of conversion of recent-onset atrial fibrillation- A single-blinded, randomized clinical trial. American Heart Journal. ISSN 0002-8703. 221, p. 114–124. doi: 10.1016/j.ahj.2019.12.014. Full text in Research Archive
• Tazmini, Kiarash; Frisk, Michael; Lewalle, Alexandre; Laasmaa, Martin; Morotti, Stefano & Lipsett, David Bruce [Show all 16 contributors for this article] (2020). Hypokalemia promotes arrhythmia by distinct mechanisms in atrial and ventricular myocytes. Circulation Research. ISSN 0009-7330. 126(7), p. 889–906. doi: 10.1161/CIRCRESAHA.119.315641. Full text in Research Archive
• Berge, Torkil; Bull-Hansen, Bente; Solberg, Erik Ekker; Heyerdahl, Else Resser; Jørgensen, Kjetil Nordbø & Vinge, Leif Erik [Show all 9 contributors for this article] (2019). Screening for symptomer på depresjon og angst ved en hjertemedisinsk avdeling. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 139(14). doi: 10.4045/tidsskr.18.0570.
• Fosshaug, Linn Elisabeth Lillerud; Colas, Romain A.; Anstensrud, Anne Kristine; Gregersen, Ida; Nymoen, Ståle H. & Sagen, Ellen [Show all 15 contributors for this article] (2019). Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. EBioMedicine. ISSN 2352-3964. 46, p. 264–273. doi: 10.1016/j.ebiom.2019.07.024. Full text in Research Archive
• Tazmini, Kiarash; Nymo, Ståle Haugset; Louch, William Edward; Ranhoff, Anette Hylen & Øie, Erik (2019). Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study. PLOS ONE. ISSN 1932-6203. 14(4). doi: 10.1371/journal.pone.0215673. Full text in Research Archive
• Eek, Anne Katrine; Øie, Erik & Granås, Anne Gerd (2017). Prescribing of NOACs has outnumbered warfarin: exploring how physicians choose anticoagulant treatments. European Journal of Clinical Pharmacology. ISSN 0031-6970. 74(3), p. 323–330. doi: 10.1007/s00228-017-2374-4.
• Berge, Torkil; Finset, Arnstein; Fjerstad, Elin; Henriksen, Lise Søvde; Hyldmo, Ingrid & Lang, Nina [Show all 8 contributors for this article] (2017). Kartlegging av depressive symptomer ved hjertesykdom : hjertesykdom øker risikoen for depresjon. Hvordan kan man best fange opp deprimerte hjertepasienter? Sykepleien Forskning. ISSN 1890-2936. 2017, p. 1–8. doi: 10.4220/Sykepleienf.2017.60372.
• Halvorsen, Sigrun; Jortveit, Jarle; Hasvold, Pål; Thuresson, Marcus & Øie, Erik (2016). Initiation of and long-term adherence to secondary preventive drugs after acute myocardial infarction. BMC Cardiovascular Disorders. ISSN 1471-2261. 16(115). doi: 10.1186/s12872-016-0283-6.
• Fosshaug, Linn Elisabeth Lillerud; Dahl, Christen Peder; Risnes, Ivar; Bohov, Pavol; Berge, Rolf Kristian & Nymo, Ståle Haugset [Show all 12 contributors for this article] (2015). Altered Levels of Fatty Acids and Inflammatory and Metabolic Mediators in Epicardial Adipose Tissue in Patients With Systolic Heart Failure. Journal of Cardiac Failure. ISSN 1071-9164. 21(11), p. 916–923. doi: 10.1016/j.cardfail.2015.07.014.
• Øie, Erik; Berge, Rolf Kristian; Ueland, Thor; Dahl, Christen Peder; Edvardsen, Thor & Beitnes, Jan Otto [Show all 9 contributors for this article] (2013). Tetradecylthioacetic Acid Increases Fat Metabolism and Improves Cardiac Function in Experimental Heart Failure. Lipids. ISSN 0024-4201. 48(2), p. 139–154. doi: 10.1007/s11745-012-3749-z.
• Ueland, Thor; Svardal, Asbjørn M.; Øie, Erik; Askevold, Erik Tandberg; Nymoen, Ståle H. & Bjørndal, Bodil [Show all 10 contributors for this article] (2013). Disturbed carnitine regulation in chronic heart failure - Increased plasma levels of palmitoyl-carnitine are associated with poor prognosis. International Journal of Cardiology. ISSN 0167-5273. 167(5), p. 1892–1899. doi: 10.1016/j.ijcard.2012.04.150.
• Astrup, Elisabeth; Lekva, Tove; Davi, Giovanni; Otterdal, Kari; Santilli, Francesca & Øie, Erik [Show all 13 contributors for this article] (2012). A Complex Interaction between Rickettsia conorii and Dickkopf-1-Potential Role in Immune Evasion Mechanisms in Endothelial Cells. PLOS ONE. ISSN 1932-6203. 7(9). doi: 10.1371/journal.pone.0043638. Full text in Research Archive
• Beitnes, Jan Otto; Øie, Erik; Shahdafar, Aboulghassem; Karlsen, Tommy Aleksander; Müller, Regine & Aakhus, Svend [Show all 8 contributors for this article] (2012). Intramyocardial Injections of Human Mesenchymal Stem Cells Following Acute Myocardial Infarction Modulate Scar Formation and Improve Left Ventricular Function. Cell Transplantation. ISSN 0963-6897. 21(8), p. 1697–1709. doi: 10.3727/096368911X627462.
• Sikkeland, Liv Ingunn Bjoner; Dahl, Christen Peder; Ueland, Thor; Andreassen, Arne K.; Gude, Einar & Edvardsen, Thor [Show all 12 contributors for this article] (2012). Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure. PLOS ONE. ISSN 1932-6203. 7(5:e36815). doi: 10.1371/journal.pone.0036815.
• Røsjø, Helge; Stridsberg, Mats; Florholmen, Geir; Stensløkken, Kåre-Olav; Ottesen, Anett Hellebø & Sjaastad, Ivar [Show all 12 contributors for this article] (2012). Secretogranin II; a Protein Increased in the Myocardium and Circulation in Heart Failure with Cardioprotective Properties. PLOS ONE. ISSN 1932-6203. 7(5). doi: 10.1371/journal.pone.0037401.
• Yndestad, Arne; Finsen, Alexandra; Ueland, Thor; Husberg, Cathrine; Dahl, Christen Peder & Øie, Erik [Show all 19 contributors for this article] (2012). The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure. PLOS ONE. ISSN 1932-6203. 7(3). doi: 10.1371/journal.pone.0033038.
• Lillerud, Linn Elisabeth; Berge, Rolf Kristian; Beitnes, Jan Otto; Berge, Kjetil; Vik, Hogne & Aukrust, Pål [Show all 9 contributors for this article] (2011). Krill oil attenuates left ventricular dilatation after myocardial infarction in rats. Lipids in Health and Disease. ISSN 1476-511X. 10. doi: 10.1186/1476-511X-10-245. Show summary

  Background: In the western world, heart failure (HF) is one of the most important causes of cardiovascular mortality. Supplement with n-3 polyunsaturated fatty acids (PUFA) has been shown to improve cardiac function in HF and to decrease mortality after myocardial infarction (MI). The molecular structure and composition of n-3 PUFA varies between different marine sources and this may be of importance for their biological effects. Krill oil, unlike fish oil supplements, contains the major part of the n-3 PUFA in the form of phospholipids. This study investigated effects of krill oil on cardiac remodeling after experimental MI. Rats were randomised to pre-treatment with krill oil or control feed 14 days before induction of MI. Seven days post-MI, the rats were examined with echocardiography and rats in the control group were further randomised to continued control feed or krill oil feed for 7 weeks before re-examination with echocardiography and euthanization. Results: The echocardiographic evaluation showed significant attenuation of LV dilatation in the group pretreated with krill oil compared to controls. Attenuated heart weight, lung weight, and levels of mRNA encoding classical markers of LV stress, matrix remodeling and inflammation reflected these findings. The total composition of fatty acids were examined in the left ventricular (LV) tissue and all rats treated with krill oil showed a significantly higher proportion of n-3 PUFA in the LV tissue, although no difference was seen between the two krill oil groups. Conclusions: Supplement with krill oil leads to a proportional increase of n-3 PUFA in myocardial tissue and supplement given before induction of MI attenuates LV remodeling.

• Øie, Erik; Ueland, Thor; Dahl, Christen Peder; Bohov, Pavol; Berge, Christ & Yndestad, Arne [Show all 9 contributors for this article] (2011). Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality. Journal of Internal Medicine. ISSN 0954-6820. 270(3), p. 263–272. doi: 10.1111/j.1365-2796.2011.02384.x.
• Andersen, Geir Øystein; Knudsen, Eva Cecilie; Aukrust, Pål; Yndestad, Arne; Øie, Erik & Muller, Carl [Show all 8 contributors for this article] (2011). Elevated serum osteoprotegerin levels measured early after acute ST-elevation myocardial infarction predict final infarct size. Heart. ISSN 1355-6037. 97(6), p. 460–465. doi: 10.1136/hrt.2010.206714.
• Ahmed, Muhammad Shakil; Gravning, Jørgen A.; Martinov, Vladimir Nikolkaev; von Lueder, Thomas Gero; Edvardsen, Thor & Czibik, Gabor Tamas [Show all 11 contributors for this article] (2011). Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 300(4), p. H1291–H1302. doi: 10.1152/ajpheart.00604.2010.
• Øie, Erik; Sandberg, Wiggo Johan; Ahmed, Muhammad Shakil; Yndestad, Arne; Lærum, Ole Didrik & Attramadal, Håvard [Show all 8 contributors for this article] (2010). Activation of Notch signaling in cardiomyocytes during post-infarction remodeling. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 44(6), p. 359–366. doi: 10.3109/14017431.2010.511256.
• Bergestuen, Deidi Ann; Edvardsen, Thor; Aakhus, Svend; Ueland, Thor; Øie, Erik & Vatn, Morten H [Show all 8 contributors for this article] (2010). Activin A in Carcinoid Heart Disease: A Possible Role in Diagnosis and Pathogenesis. Neuroendocrinology. ISSN 0028-3835. 92(3), p. 168–177. doi: 10.1159/000318014.
• Michelsen, Annika ; Rathcke, CN; Skjelland, Mona; Holm, Sverre; Ranheim, Trine & Krohg-Sørensen, Kirsten [Show all 12 contributors for this article] (2010). Increased YKL-40 expression in patients with carotid atherosclerosis. Atherosclerosis. ISSN 0021-9150. 211(2), p. 589–595. doi: 10.1016/j.atherosclerosis.2010.02.035.
• Røsjø, Helge; Husberg, Cathrine; Dahl, Mai Britt; Stridsberg, Mats; Sjaastad, Ivar & Finsen, Alexandra [Show all 10 contributors for this article] (2010). Chromogranin B in Heart Failure A Putative Cardiac Biomarker Expressed in the Failing Myocardium. Circulation: Heart Failure. ISSN 1941-3289. 3(4), p. 503–511. doi: 10.1161/CIRCHEARTFAILURE.109.867747.
• Øie, Erik; Ahmed, Muhammad Shakil; Ueland, Thor; Sikkeland, Liv Ingunn Bjoner; Dahl, Christen Peder & Hagelin, Else Marie Valbjørn [Show all 14 contributors for this article] (2010). Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure. Basic Research in Cardiology. ISSN 0300-8428. 105(1), p. 89–98. doi: 10.1007/s00395-009-0070-y.
• Bergestuen, Deidi Ann; Gravning, Jørgen Amundsen; Haugaa, Kristina; Sahakyan, LG; Aakhus, Svend & Thiis-Evensen, Espen [Show all 10 contributors for this article] (2010). Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors. BMC Cancer. ISSN 1471-2407. 10. doi: 10.1186/1471-2407-10-6.
• Breland, Unni Mathilde; Michelsen, Annika ; Skjelland, Mona; Folkersen, L; Krohg-Sørensen, Kirsten & Russell, David [Show all 14 contributors for this article] (2010). Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation. Cardiovascular Research (CVR). ISSN 0008-6363. 86(2), p. 265–273. doi: 10.1093/cvr/cvq044.
• Sandberg, Wiggo Johan; Halvorsen, Bente ; Yndestad, Arne; Smith, Camilla; Otterdal, Kari & Brosstad, Frank Roger [Show all 13 contributors for this article] (2009). Inflammatory Interaction Between LIGHT and Proteinase-Activated Receptor-2 in Endothelial Cells. Potential Role in Atherogenesis. Circulation Research. ISSN 0009-7330. 104(1), p. 60–U192. doi: 10.1161/CIRCRESAHA.108.188078. Show summary

  The interaction between inflammatory cytokines and endothelial cells is a critical step in atherogenesis leading to endothelial dysfunction and inflammation. We have previously reported that the tumor necrosis factor superfamily member LIGHT could be involved in atherogenesis through its ability to promote vascular inflammation. In the present study we identified proteinase-activated receptor (PAR)-2 as an inflammatory mediator that was markedly enhanced by LIGHT in endothelial cells. We also found that LIGHT acted synergistically with PAR-2 activation to promote enhanced release of the proatherogenic chemokines interleukin-8 and monocyte chemoattractant protein-1, underscoring that the interaction between LIGHT and PAR-2 is biologically active, promoting potent inflammatory effects. We showed that the LIGHT-mediated upregulation of PAR-2 in endothelial cells is mediated through the HVEM receptor, involving Jun N-terminal kinase signaling pathways. A LIGHT-mediated upregulation of PAR-2 mRNA levels was also found in human monocytes when these cells were preactivated by tumor necrosis factor {alpha}. We have previously demonstrated increased plasma levels of LIGHT in unstable angina patients, and here we show a similar pattern for PAR-2 expression in peripheral blood monocytes. We also found that LIGHT, LIGHT receptors, and PAR-2 showed enhanced expression, and, to some degree, colocalization in endothelial cells and macrophages, in the atherosclerotic plaques of ApoE–/– mice, suggesting that the inflammatory interaction between LIGHT and PAR-2 also may be operating in vivo within an atherosclerotic lesion. Our findings suggest that LIGHT/PAR-2–driven inflammation could be a pathogenic loop in atherogenesis potentially representing a target for therapy in this disorder.

• Yndestad, Arne; Larsen, Karl-Otto; Øie, Erik; Ueland, Thor; Smith, Camilla & Halvorsen, Bente [Show all 14 contributors for this article] (2009). Elevated levels of activin A in clinical and experimental pulmonary hypertension. Journal of applied physiology. ISSN 8750-7587. 106(4), p. 1356–1364. doi: 10.1152/japplphysiol.90719.2008.
• Yndestad, A; Landrø, Linn; Ueland, Thor; Dahl, CP; Flo, Trude Helen & Vinge, Leif Erik [Show all 15 contributors for this article] (2009). Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. European Heart Journal. ISSN 0195-668X. 30(10), p. 1229–1236. doi: 10.1093/eurheartj/ehp088. Show summary

  Aims: Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2) is a glycoprotein with bacteriostatic properties. Growing evidence suggests that NGAL may also be involved in cell survival, inflammation, and matrix degradation. We therefore aimed to investigate the role of NGAL in heart failure (HF). Methods and results: Our main findings were (i) patients with acute post-myocardial infarction (MI) HF (n = 236) and chronic HF (n = 150) had elevated serum levels of NGAL (determined by enzyme immunoassay), significantly correlated with clinical and neurohormonal deterioration, (ii) in patients with HF following acute MI, elevated NGAL levels of at baseline were associated with adverse outcomes (median of 27 months follow-up), (iii) in a rat model of post-MI HF, NGAL/lipocalin-2 gene expression was increased in the non-ischaemic part of the left ventricle primarily located to cardiomyocytes, (iv) strong NGAL immunostaining was found in cardiomyocytes within the failing myocardium both in experimental and clinical HF, (v) interleukin-1β and agonists for toll-like receptors 2 and 4, representing components of the innate immune system, were potent inducers of NGAL/lipocalin-2 in isolated neonatal cardiomyocytes. Conclusion: Our demonstration of enhanced systemic and myocardial NGAL expression in clinical and experimental HF further support a role for innate immune responses in the pathogenesis of HF.

• Yndestad, Arne; Neurauter, Christine Gran; Øie, Erik; Johansen, Rune Forstrøm; Vinge, Leif Erik & Eide, Lars [Show all 9 contributors for this article] (2009). Up-regulation of myocardial DNA base excision repair activities in experimental heart failure. Mutation research. ISSN 0027-5107. 666(1-2), p. 32–38. doi: 10.1016/j.mrfmmm.2009.03.008.
• Dahl, Christen Peder; Husberg, Cathrine; Gullestad, Lars; Wæhre, Anne; Damås, Jan Kristian & Vinge, Leif Erik [Show all 15 contributors for this article] (2009). Increased Production of CXCL16 in Experimental and Clinical Heart Failure: A Possible Role in Extracellular Matrix Remodeling. Circulation: Heart Failure. ISSN 1941-3289. 2(6), p. 624–632. doi: 10.1161/CIRCHEARTFAILURE.108.821074.
• Ueland, Thor; Otterdal, Kari; Lekva, Tove; Halvorsen, Bente ; Gabrielsen, A & Sandberg, Wiggo Johan [Show all 13 contributors for this article] (2009). Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 29(8), p. 1228–1234. doi: 10.1161/ATVBAHA.109.189761.
• Sandberg, Wiggo Johan; Otterdal, Kari; Gullestad, Lars; Halvorsen, Bente ; Ragnarsson, Asgrimur & Frøland, Stig Sophus [Show all 11 contributors for this article] (2009). The tumour necrosis factor superfamily ligand APRIL (TNFSF13) is released upon platelet activation and expressed in atherosclerosis. Thrombosis and Haemostasis. ISSN 0340-6245. 102(4), p. 704–710. doi: 10.1160/TH08-10-0665.
• Aukrust, Pål; Halvorsen, Bente ; Yndestad, Arne; Ueland, Thor; Øie, Erik & Otterdal, Kari [Show all 8 contributors for this article] (2008). Chemokines and cardiovascular risk. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 28(11), p. 1909–1919. doi: 10.1161/ATVBAHA.107.161240.
• Otterdal, Kari; Andreassen, Arne K.; Yndestad, Arne; Øie, Erik; Sandberg, Wiggo Johan & Dahl, Christen Peder [Show all 12 contributors for this article] (2008). Raised LIGHT Levels in Pulmonary Arterial Hypertension - Potential Role in Thrombus Formation. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 177, p. 202–207. doi: 10.1164/rccm.200703-506OC.
• Smith, Camilla; Halvorsen, Bente ; Otterdal, Kari; Wæhre, Torgun; Yndestad, Arne & Fevang, Børre [Show all 13 contributors for this article] (2008). High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins. Cardiovascular Research (CVR). ISSN 0008-6363. 79, p. 195–203. doi: 10.1093/cvr/cvn071.
• Husberg, Cathrine; Nygård, Ståle; Finsen, Alexandra; Damås, Jan Kristian; Frigessi, Arnoldo & Øie, Erik [Show all 11 contributors for this article] (2008). Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 45, p. 261–269. doi: 10.1016/j.yjmcc.2008.05.009.
• Aukrust, Pål; Otterdal, K; Yndestad, Arne; Sandberg, Wiggo Johan; Smith, Camilla & Ueland, Thor [Show all 10 contributors for this article] (2008). The complex role of T-cell-based immunity in atherosclerosis. Current Atherosclerosis Reports. ISSN 1523-3804. 10, p. 236–243.
• Halvorsen, Bente ; Otterdal, K; Dahl, TB; Skjelland, Mona; Gullestad, Lars & Øie, Erik [Show all 7 contributors for this article] (2008). Atherosclerotic Plaque Stability-What Determines the Fate of a Plaque? Progress in cardiovascular diseases. ISSN 0033-0620. 51(3), p. 183–194. doi: 10.1016/j.pcad.2008.09.001.
• Handberg, Aase; Skjelland, Mona; Michelsen, Annika ; Sagen, Ellen Lund; Krohg-Sørensen, Kirsten & Russell, David [Show all 11 contributors for this article] (2008). Soluble CD36 in plasma is increased in patients with symptomatic atherosclerotic carotid plaques and is related to plaque instability. Stroke. ISSN 0039-2499. 39, p. 3092–3095. doi: 10.1161/STROKEAHA.108.517128.
• Breland, Unni Mathilde; Halvorsen, Bente ; Hol, Johanna; Øie, Erik; Paulsson-Berne, G & Yndestad, Arne [Show all 17 contributors for this article] (2008). A potential role of the CXC chemokine GRO alpha in atherosclerosis and plaque destabilization - Downregulatory effects of statins. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 28. doi: 10.1161/ATVBAHA.108.162305.
• Pleger, ST; Harris, DM; Shan, CG; Vinge, Leif Erik; Chuprun, JK & Berzins, B [Show all 17 contributors for this article] (2008). Endothelial S100A1 modulates vascular function via nitric oxide. Circulation Research. ISSN 0009-7330. 102. doi: 10.1161/CIRCRESAHA.108.172031.
• Dahl, Christen Peder; Gullestad, Lars; Fevang, Børre; Holm, Are Martin; Landrø, Linn Aina Ysland & Vinge, Leif Erik [Show all 15 contributors for this article] (2008). Increased expression of LIGHT/TNFSF 14 and its receptors in experimental and clinical heart failure. European Journal of Heart Failure. ISSN 1388-9842. 10, p. 352–359. doi: 10.1016/j.ejheart.2008.02.010.
• Husberg, Cathrine; Nygård, Ståle; Finsen, Alexandra Vanessa; Damås, Jan Kristian; Frigessi, Arnoldo & Øie, Erik [Show all 10 contributors for this article] (2007). Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 42( 6), p. 152–153.
• Aukrust, Pål; Yndestad, Arne; Damås, Jan Kristian; Ueland, Thor; Øie, Erik & Gullestad, Lars (2007). Potential mechanisms of benefit with thalidomide in chronic heart failure. American Journal of Cardiovascular Drugs. ISSN 1175-3277. 7, p. 127–134.
• Ahmed, Muhammad Shakil; Øie, Erik; Vinge, Leif Erik; von Lueder, Thomas Gero; Attramadal, T & Attramadal, Håvard (2007). Induction of pulmonary connective tissue growth factor in heart failure is associated with pulmonary parenchymal and vascular remodeling. Cardiovascular Research (CVR). ISSN 0008-6363. 74, p. 323–333. doi: 10.1016/j.cardiores.2006.12.010.
• Gullestad, Lars; Øie, Erik; Ueland, Thor; Yndestad, Arne & Aukrust, Pål (2007). The role of statins in heart failure. Fundamental & Clinical Pharmacology. ISSN 0767-3981. 21, p. 35–40. doi: 10.1111/j.1365-2184.2007.00538.x.
• Yndestad, Arne; Damås, Jan Kristian; Øie, Erik; Ueland, Thor; Gullestad, Lars & Aukrust, Pål (2007). Role of inflammation in the progression of heart failure. Current Cardiology Reports. ISSN 1523-3782. 9, p. 236–241.
• Dahl, Tuva Børresdatter; Yndestad, Arne; Skjelland, Mona; Øie, Erik; Dahl, Arve & Michelsen, Annika [Show all 18 contributors for this article] (2007). Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization. Circulation. ISSN 0009-7322. 115, p. 972–980. doi: 10.1161/CIRCULATIONAHA.106.665893.
• Damås, Jan Kristian; Smith, Camilla; Øie, Erik; Fevang, Børre; Halvorsen, Bente & Waehre, Torgun [Show all 19 contributors for this article] (2007). Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis - Possible pathogenic role in plaque destabilization. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 27, p. 614–620. doi: 10.1161/01.ATV.0000255581.38523.7c.

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• Nome, Ragnhild Veline; Amundsen, Erik Koldberg; Tvedt, Tor Henrik Anderson; Fenstad, Mona H. & Øie, Erik (2023). Hvor ofte bør man gjenta blodprøver? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(1). doi: 10.4045/tidsskr.22.0658.
• Kolden, Mathias Øie; Nymo, Ståle Haugset & Øie, Erik (2022). Correction: Impact of neighbourhood-level socioeconomic status, traditional coronary risk factors, and ancestry on age at myocardial infarction onset: A population-based register study (BMC Cardiovascular Disorders, (2022), 22, 1, (447), 10.1186/s12872-022-02880-7). BMC Cardiovascular Disorders. ISSN 1471-2261. 22(1). doi: 10.1186/s12872-022-02938-6.
• Øie, Erik (2016). Over 80 år og hjerteinfarkt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(12/13), p. 1058–1058. doi: 10.4045/tidsskr.16.0458.
• Øie, Erik (2016). E. Øie svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(16), p. 1325–1325. doi: 10.4045/tidsskr.16.0688.
• Tazmini, Kiarash; Frisk, Michael; Lipsett, David Bruce; Aronsen, Jan Magnus; Sjaastad, Ivar & Øie, Erik [Show all 7 contributors for this article] (2016). Pro-arrhythmic consequences of hypokalemia in atrial cardiomyocytes.
• Hommerstad, Anders; Hall, Kirsten Sundby; Bjerkehagen, Bodil; Eskild, Trond H.; Geiran, Odd & Øie, Erik (2014). En kvinne i 50-årene med tungpustethet og hypotensjon. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(18), p. 1758–1761. doi: 10.4045/tidsskr.13.1110.
• Hommerstad, Anders; Hall, Kirsten Sundby; Bjerkehagen, Bodil; Eskild, Trond H.; Geiran, Odd & Øie, Erik (2014). Kvinne i 50-årene med tungpustethet og hypotensjon. Tidsskrift for Den norske legeforening. ISSN 0029-2001. p. 1758–1761. doi: 10.4045/tidsskr.13.1110.
• Tazmini, Kiarash; Frisk, Michael; Aronsen, Jan Magnus; Sjaastad, Ivar; Øie, Erik & Louch, William Edward (2014). Pro-arrhythmic consequences of hypokalemia in atrial cardiomyocytes.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Stridsberg, Mats & Sjaastad, Ivar [Show all 10 contributors for this article] (2012). Secretoneurin is increased in the myocardium in heart failure and may influence pathophysiology by modulating cardiomyocyte calcium homeostasis.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Stridsberg, Mats & Sjaastad, Ivar [Show all 10 contributors for this article] (2012). Secretoneurin is increased in the myocardium in heart failure and may influence pathophysiology by modulating cardiomyocyte calcium homeostasis. Cardiovascular Research (CVR). ISSN 0008-6363. 93, p. S108–S109. doi: 10.1093/cvr/cvr336.
• Bergestuen, Deidi Ann; Edvardsen, Thor; Aakhus, Svend; Ueland, Thor; Øie, Erik & Vatn, Morten H [Show all 8 contributors for this article] (2012). Activin A in Carcinoid Heart Disease: A Possible Role in Diagnosis and Pathogenesis. Pancreas. ISSN 0885-3177. 41(2), p. 339–339.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Høiseth, Arne Didrik & Stridsberg, Mats [Show all 10 contributors for this article] (2011). Secretoneurin, a peptide associated with mortality in heart failure, modulates cardiomyocyte calcium homeostasis.
• Ottesen, Anett Hellebø; Louch, William Edward; Carlson, Cathrine Rein; Landsverk, Ole J. B.; Høiseth, Arne Didrik & Stridsberg, Mats [Show all 10 contributors for this article] (2011). Secretoneurin, a peptide associated with mortality in heart failure, modulates cardiomyocyte calcium homeostasis. Circulation. ISSN 0009-7322. 124.
• Øie, Erik; Ueland, Thor; Dahl, Christen Peder; Bohov, Pavol; Berge, Christ & Yndestad, Arne [Show all 9 contributors for this article] (2010). Low circulating eicosatetraenoic acid and high vaccenic acid are associated with disease severity and predict mortality in heart failure. European Heart Journal. ISSN 0195-668X. 31(suppl 1), p. 570–570.
• Røsjø, Helge; Stridsberg, M.; Florholmen, Geir; Stensløkken, Kåre-Olav; Sjaastad, Ivar & Husberg, Cathrine [Show all 10 contributors for this article] (2010). Secretoneurin is a novel peptide increased in the myocardium and circulation in heart failure with cardioprotective properties. European Heart Journal. ISSN 0195-668X. 31, p. 314–314.
• Bergestuen, Deidi Ann; Gravning, Jørgen A.; Haugaa, Kristina; Sahakyan, Laura G.; Aakhus, Svend & Carlsen, Espen [Show all 10 contributors for this article] (2010). Plasma CCN2/Connective Tissue Growth Factor is Associated with Right Ventricular Dysfunction in Patients with Neuroendocrine Tumors. Neuroendocrinology. ISSN 0028-3835. 92(1), p. 19–19.
• Røsjø, Helge; Stridsberg, Mats; Florholmen, Geir; Stensløkken, Kåre-Olav; Sjaastad, Ivar & Husberg, Cathrine [Show all 10 contributors for this article] (2010). Secretoneurin is a novel peptide increased in the myocardium and circulation in heart failure with cardioprotective properties.
• Røsjø, Helge; Stridsberg, M; Florholmen, Geir; Stensløkken, Kåre-Olav; Sjaastad, Ivar & Husberg, Cathrine [Show all 10 contributors for this article] (2010). Secretoneurin: a novel protective agent increased in the myocardium and circulation in heart failure. Hjerteforum. ISSN 0802-1465. 23(1), p. 101–102.
• Beitnes, Jan Otto; Øie, Erik; Shahdafar, Aboulghassem; Karlsen, Tommy Aleksander; Aakhus, Svend & Brinchmann, Jan E. (2010). Mesenchymal stem cells from skeletal muscle and adipose tissue improve LV function after myocardial infarction, but do not differentiate into cardiomyocytes. European Heart Journal. ISSN 0195-668X. 31, p. 397–397.
• Dahl, Christen Peder; Husberg, Cathrine; Gullestad, Lars; Wæhre, Anne; Damås, Jan Kristian & Vinge, Leif Erik [Show all 15 contributors for this article] (2009). Increased production of CXCL16 in experimental and clinical heart failure; a possible role in extracellular matrix remodeling. Hjerteforum. ISSN 0802-1465. 22(2), p. 113–114.
• Dahl, Christen Peder; Husberg, Cathrine; Gullestad, Lars; Wæhre, Anne; Finsen, Alexandra & Halvorsen, Bente [Show all 10 contributors for this article] (2009). Increased production of CXCL16 in experimental and clinical heart failure; a possible role in extracellular matrix remodeling. European Heart Journal, Supplement. ISSN 1520-765X. 30.
• Røsjø, Helge; Husberg, Cathrine; Dahl, Mai Britt; Stridsberg, Mats; Sjaastad, Ivar & Finsen, Alexandra [Show all 10 contributors for this article] (2009). Chromogranin B: a novel myocardium-regulated biomarker in experimental and clinical heart failure. Hjerteforum. ISSN 0802-1465. 22, p. 107–107.
• Røsjø, Helge; Husberg, Cathrine; Dahl, Mai Britt; Stridsberg, Mats; Sjaastad, Ivar & Finsen, Alexandra [Show all 10 contributors for this article] (2009). The chromogranins A and B are regulated differently in the myocardium and circulation during heart failure development; complimentary cardiac biomarkers? European Heart Journal, Supplement. ISSN 1520-765X. 30, p. 134–134.
• Røsjø, Helge; Stridsberg, Mats; Husberg, Cathrine; Dahl, Mai Britt; Sjaastad, Ivar & Øie, Erik [Show all 8 contributors for this article] (2009). Secretogranin II is closely regulated in the murine myocardium and increased in the circulation of heart failure patients. Circulation. ISSN 0009-7322. 120, p. S858–S858.
• Røsjø, Helge; Husberg, Cathrine; Dahl, Mai Britt; Stridsberg, Mats; Sjaastad, Ivar & Øie, Erik [Show all 8 contributors for this article] (2009). Chromogranin B is regulated in the myocardium and circulation during heart failure development; a novel marker of cardiac disease. European Journal of Heart Failure. Supplements. ISSN 1567-4215. 8.
• Dahl, Christen Peder; Husberg, Cathrine; Gullestad, Lars; Halvorsen, Bente ; Aukrust, Pål & Øie, Erik [Show all 8 contributors for this article] (2009). Increased production of CXCL16 in experimental and clinical heart failure; a possible role in extracellular matrix remodeling. European Journal of Heart Failure. Supplements. ISSN 1567-4215. 8.
• Dahl, Christen Peder; Sikkeland, Liv Ingunn Bjoner; Andreassen, Arne K.; Gude, Einar; Gullestad, Lars & Kongerud, Johny [Show all 8 contributors for this article] (2009). Increased levels of cytokines, vasoactive peptides, and growth factors in alveolar macrophages in heart failure.
• Røsjø, Helge; Husberg, Cathrine; Dahl, Mai Britt; Stridsberg, M; Sjaastad, I & Øie, Erik [Show all 8 contributors for this article] (2009). Chromagranin B is regulated in the myocardium and circulation during heart failure development - a novel marker of cardiac disease.
• Øie, Erik; Sikkeland, Liv Ingunn Bjoner; Dahl, Christen Peder; Andreassen, Arne K.; Gude, Einar & Gullestad, Lars [Show all 8 contributors for this article] (2009). Increased levels of cytokines, vasoactive peptides, and growth factors in alveolar macrophages in heart failure.
• Øie, Erik; Sandberg, Wiggo Johan; Ahmed, MS; Vinge, Leif Erik; Gullestad, Lars & Attramadal, Håvard [Show all 8 contributors for this article] (2009). Activation of notch signalling in cardiomyocytes during post-infarction myocardial remodelling.
• Dahl, Christen Peder; Husberg, Cathrine; Gullestad, Lars; Wæhre, Torgun; Finsen, Alexandra & Halvorsen, Bente [Show all 10 contributors for this article] (2009). Increased production of CXCL16 in experimental and clinical heart failure; a possible role in extracellular matric remodeling.
• Dahl, Christen Peder; Husberg, Cathrine; Gullestad, Lars; Halvorsen, Bente ; Aukrust, Pål & Øie, Erik [Show all 8 contributors for this article] (2009). Increased production of CXCL16 in experimental and clinical heart failure, a possible role in extracellular matrix remodeling.
• Breland, Unni Mathilde; Halvorsen, Bente ; Hol, Johanna; Øie, Erik; Yndestad, Arne & Smith, Camilla [Show all 16 contributors for this article] (2008). Enhanced expression of the chemokine CXCL1 in atherosclerotic disorders, down-regulatory effects of statin.
• Dahl, Christen Peder; Husberg, Cathrine; Gullestad, Lars; Wæhre, Anne; Finsen, Alexandra & Halvorsen, Bente [Show all 10 contributors for this article] (2008). Increased production of CXCL16 in heart failure; a role in extracellular matrix remodeling.
• Husberg, Cathrine; Nygård, Ståle; Finsen, Alexandra; Damas, JK; Frigessi, Arnoldo & Øie, Erik [Show all 10 contributors for this article] (2007). Cytokine expression profiling of the myocardium reveals a role for CX3CL1 in heart failure. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 42. doi: 10.1016/j.yjmcc.2007.03.495.
• Sandberg, Wiggo Johan; Yndestad, Arne; Øie, Erik; Smith, Camilla; Otterdal, Kari & Gullestad, Lars [Show all 8 contributors for this article] (2007). APRIL a new platelet derived member of the TNF superfamily related to atherosclerotic disorders.
• Yndestad, Arne; Finsen, Alexandra; Husberg, Cathrine; Øie, Erik; Lipp, M. & Gullestad, Lars [Show all 8 contributors for this article] (2007). The homeostatic chemokines CCL19 and CCL21 are elevated in heart failure and may regulate myocardial hypertrophy.
• Yndestad, Arne; Finsen, Alexandra; Husberg, Cathrine; Øie, Erik; Damås, Jan Kristian & Lipp, M. [Show all 9 contributors for this article] (2007). The homeostatic chemokines CCL19 and CCL21 are elevated in heart failure and may regulate myocardial growth.

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