Erik Taubøll

• Sødal, Hild Flatmark; Nordseth, Trond; Rasmussen, Anders Johan Orland; Rosseland, Leiv Arne; Stenehjem, Jo & Gran, Jon Michael [Show all 8 contributors for this article] (2024). Risk of epilepsy after traumatic brain injury: a nationwide Norwegian matched cohort study. Frontiers in Neurology. ISSN 1664-2295. 15. doi: 10.3389/fneur.2024.1411692.
• Heuser, Kjell; Horn, Morten Andreas; Samsonsen, Christian; ULVIN, LINE BÉDOS; OLSEN, KE TIL BERG & POWER, KJER STI NESHEIM [Show all 10 contributors for this article] (2024). Behandling av status epilepticus hos voksne. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 144(4), p. 1–10. doi: 10.4045/tidsskr.23.0782.
• Damien, Charlotte; Leitinger, Markus; Kellinghaus, Christoph; Strzelczyk, Adam; De Stefano, Pia & Beier, Christoph P. [Show all 16 contributors for this article] (2024). Sustained effort network for treatment of status epilepticus/European academy of neurology registry on adult refractory status epilepticus (SENSE-II/AROUSE). BMC Neurology. ISSN 1471-2377. 24(1). doi: 10.1186/s12883-023-03505-y.
• Rugstad Næsgaard, Jon Andreas; Gjerstad, Leif Ingvald; Heuser, Kjell & Taubøll, Erik (2023). Biological rhythms and epilepsy treatment . Frontiers in Neurology. ISSN 1664-2295. doi: 10.3389/fneur.2023.1153975. Full text in Research Archive
• Mochol, Monika; Taubøll, Erik; Aukrust, Pål; Ueland, Thor; Andreassen, Ole & Svalheim, Sigrid (2023). Serum Markers of Neuronal Damage and Astrocyte Activity in Patients with Chronic Epilepsy: Elevated Levels of Glial Fibrillary Acidic Protein. Acta Neurologica Scandinavica. ISSN 0001-6314. 2023, p. 1–5. doi: 10.1155/2023/7246373. Full text in Research Archive
• Stevelink, Remi; Campbell, Ciarán; Chen, Siwei; Abou-Khalil, Bassel; Adesoji, Oluyomi M. & Afawi, Zaid [Show all 319 contributors for this article] (2023). GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. Nature Genetics. ISSN 1061-4036. 55(9), p. 1471–1482. doi: 10.1038/s41588-023-01485-w. Full text in Research Archive
• Molteberg, Ellen; Thorsby, Per Medbøe; Kverneland, Magnhild; Iversen, Per Ole; Selmer, Kaja Kristine & Hofoss, Dag [Show all 8 contributors for this article] (2023). Stress biomarkers in adult patients with drug-resistant epilepsy on a modified Atkins diet: A prospective study. Epilepsia Open. ISSN 2470-9239. 8, p. 1331–1339. doi: 10.1002/epi4.12808. Full text in Research Archive
• Karadag, Naz; Shadrin, Alexey; O'Connell, Kevin Sean; Hindley, Guy Frederick Lanyon; Rahman, Zillur & Parker, Nadine [Show all 18 contributors for this article] (2023). Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders. Brain. ISSN 0006-8950. 146(8), p. 3392–3403. doi: 10.1093/brain/awad038. Full text in Research Archive
• Hatlestad-Hall, Christoffer; Bruña, Ricardo; Liljeström, Mia; Renvall, Hanna; Heuser, Kjell & Taubøll, Erik [Show all 8 contributors for this article] (2023). Reliable evaluation of functional connectivity and graph theory measures in source-level EEG: How many electrodes are enough? Clinical Neurophysiology. ISSN 1388-2457. 150, p. 1–16. doi: 10.1016/j.clinph.2023.03.002. Full text in Research Archive
• Berger, Toni; Taubøll, Erik & Heuser, Kjell (2022). The potential role of DNA methylation as preventive treatment target of epileptogenesis. Frontiers in Cellular Neuroscience. ISSN 1662-5102. 16, p. 1–13. doi: 10.3389/fncel.2022.931356. Full text in Research Archive
• Sødal, Hild Flatmark; Storvig, Gøril; Tverdal, Cathrine Buaas; Robinson, Hilde Stendal; Helseth, Eirik & Taubøll, Erik (2022). Early post-traumatic seizures in hospitalized patients with traumatic brain injury. Acta Neurologica Scandinavica. ISSN 0001-6314. 146(5), p. 485–491. doi: 10.1111/ane.13670. Full text in Research Archive
• Herrman, Helle; Osnes, Kåre; Egge, Arild; Konglund, Ane; Ramm-Pettersen, Jon-Terje & Dietrichs, Espen [Show all 7 contributors for this article] (2022). ANT-DBS in epilepsy shows no effect on selected neuropsychiatric tests. Acta Neurologica Scandinavica. ISSN 0001-6314. 146(3), p. 258–264. doi: 10.1111/ane.13658. Full text in Research Archive
• Bakhtiari, Aftab; Bjørke, Agnes Balint; Larsson, Pål Gunnar; Olsen, Ketil Berg; Nævra, Marianne C. Johansen & Taubøll, Erik [Show all 8 contributors for this article] (2022). Episodic Memory Dysfunction and Effective Connectivity in Adult Patients With Newly Diagnosed Nonlesional Temporal Lobe Epilepsy. Frontiers in Neurology. ISSN 1664-2295. 13, p. 1–12. doi: 10.3389/fneur.2022.774532. Full text in Research Archive Show summary

  Objective: Epilepsy is associated with both changes in brain connectivity and memory function, usually studied in the chronic patients. The aim of this study was to explore the presence of connectivity alterations measured by EEG in the parietofrontal network in patients with temporal lobe epilepsy (TLE), and to examine episodic memory, at the time point of diagnosis. Methods: The parietofrontal network of newly diagnosed patients with TLE (N = 21) was assessed through electroencephalography (EEG) effective connectivity and compared with that of matched controls (N = 21). Furthermore, we assessed phenomenological aspects of episodic memory in both groups. Association between effective connectivity and episodic memory were assessed through correlation. Results: Patients with TLE displayed decreased episodic (p ≤ 0.001, t = −5.18) memory scores compared with controls at the time point of diagnosis. The patients showed a decreased right parietofrontal connectivity (p = 0.03, F = 4.94) compared with controls, and significantly weaker connectivity in their right compared with their left hemisphere (p = 0.008, t = −2.93). There were no significant associations between effective connectivity and episodic memory scores. Conclusions: We found changes in both memory function and connectivity at the time point of diagnosis, supporting the notion that TLE involves complex memory functions and brain networks beyond the seizure focus to strongly interconnected brain regions, already early in the disease course. Whether the observed connectivity changes can be interpreted as functionally important to the alterations in memory function, it remains speculative.

• Zelano, Johan; Sveberg, Line; Taubøll, Erik & Tomson, Torbjörn (2022). Valproate Restrictions in Sweden and Norway: Online survey suggests implementation deficit. Acta Neurologica Scandinavica. ISSN 0001-6314. 145(5), p. 551–556. doi: 10.1111/ane.13581. Show summary

  Objectives To assess knowledge among neurologists in Sweden and Norway on the restrictions issued by the European Medicines Agency (EMA) regarding use of valproic acid (VPA) to female patients of childbearing potential, their use of the pregnancy prevention programme and their VPA prescription habits. Materials & Methods We conducted an online survey from May through September 2021 inviting neurologists in Sweden and Norway to participate. The questions assessed familiarity with the EMA restrictions, knowledge and use of the information material issued by Market Authorization Holders (MAH) of VPA, and experience of VPA prescriptions to women of childbearing age in the last 2 years. Results The survey received 202 responses (response rate ≈ 20%). Of the responders, 51% were well acquainted with the EMA restrictions, and 49% were aware of the MAH-issued educational material. Eighty-eight (44%) had prescribed VPA to women of childbearing age in the last 2 years, and of these, only a small minority (n = 13) regularly used the information brochure for patients, and even fewer (n = 8) the VPA risk acknowledgement forms. Conclusions We found limited penetrance of the new EMA restrictions on VPA use as well as limited acceptance and use among prescribers of the current company-issued information material and risk acknowledgment forms. More information campaigns and closer collaboration with treating physicians are likely needed.

• Roberg, Lars Egil; Monsson, Olav; Kristensen, Simon Bang; Dahl, Svein Magne; Ulvin, Line Bédos & Heuser, Kjell [Show all 15 contributors for this article] (2022). Prediction of Long-term Survival after Status Epilepticus Using the ACD Score. JAMA Neurology. ISSN 2168-6149. 79(6), p. 604–613. doi: 10.1001/jamaneurol.2022.0609. Show summary

  Importance Early prediction of long-term mortality in status epilepticus is important given the high fatality rate in the years after diagnosis. Objective To improve prognostication of long-term mortality after status epilepticus diagnosis. Design, Settings, and Participants This retrospective, multicenter, multinational cohort study analyzed adult patients who were diagnosed with and treated for status epilepticus at university hospitals in Odense, Denmark, between January 1, 2008, and December 31, 2017, as well as in Oslo, Norway; Marburg, Germany; and Frankfurt, Germany. They were aged 18 years or older and had first-time, nonanoxic status epilepticus. A new scoring system, called the ACD score, for predicting 2-year (long-term) mortality after hospital discharge for status epilepticus was developed in the Danish cohort and validated in the German and Norwegian cohorts. The ACD score represents age at onset, level of consciousness at admission, and duration of status epilepticus. Data analysis was performed between September 1, 2019, and March 31, 2020. Exposures Long-term follow-up using data from national and local civil registries in Denmark, Norway, and Germany. Main Outcomes and Measures The predefined end point was 2-year survival for all patients and for a subgroup of patients with status epilepticus causes that were not damaging or were less damaging to the brain. Neurological deficits before and after onset, demographic characteristics, etiological categories of status epilepticus, comorbidities, survival, time points, treatments, and prognostic scores for different measures were assessed. Results A total of 261 patients (mean [SD] age, 67.2 [14.8] years; 132 women [50.6%]) were included, of whom 145 patients (mean [SD] age, 66.3 [15.0] years; 78 women [53.8%]) had status epilepticus causes that were not damaging or were less damaging to the brain. The validation cohort comprised patients from Norway (n = 139) and Germany (n = 906). At hospital discharge, 29.8% of patients (n = 64 of 215) had new moderate to severe neurological deficits compared with baseline. New neurological deficits were a major predictor of 2-year survival after hospital discharge (odds ratio, 5.1; 95% CI, 2.2-11.8); this association was independent of etiological category. Nonconvulsive status epilepticus in coma and duration of status epilepticus were associated with development of new neurological deficits, and a simple 3-factor score (ACD score) combining these 2 risk factors with age at onset was developed to estimate survival after status epilepticus diagnosis. The ACD score had a linear correlation with 2-year survival (Pearson r2 = 0.848), especially in the subset of patients with a low likelihood of brain damage. Conclusions and Relevance This study found that age, long duration, and nonconvulsive type of status epilepticus in coma were associated with the development of new neurological deficits, which were predictors of long-term mortality. Accounting for risk factors for new neurological deficits using the ACD score is a reliable method of prediction of long-term outcome in patients with status epilepticus causes that were not damaging or were less damaging to the brain.

• Gonzalez, Alba; Haugaa, Kristina Ingrid Helena Hermann; Brekke, Pål Haugar; Hopp, Einar; Ørn, Stein & Alvestad, Silje [Show all 8 contributors for this article] (2022). Cardiac Structure and Function in Epilepsy Patients with Drug-Resistant Convulsive Seizures. Case Reports in Neurology. ISSN 1662-680X. 14(1), p. 88–97. doi: 10.1159/000522237. Full text in Research Archive
• Molteberg, Ellen; Taubøll, Erik; Kverneland, Magnhild; Iversen, Per Ole; Selmer, Kaja Kristine & Nakken, Karl Otto [Show all 8 contributors for this article] (2022). Substantial early changes in bone and calcium metabolism among adult pharmacoresistant epilepsy patients on a modified Atkins diet. Epilepsia. ISSN 0013-9580. 63(4), p. 880–891. doi: 10.1111/epi.17169. Full text in Research Archive Show summary

  Abstract Objective The aim of this study was to investigate whether the modified Atkins diet (MAD), a variant of the ketogenic diet, has an impact on bone- and calcium (Ca) metabolism. Methods Two groups of adult patients with pharmacoresistant epilepsy were investigated. One, the diet group (n = 53), was treated with MAD for 12 weeks, whereas the other, the reference group (n = 28), stayed on their habitual diet in the same period. All measurements were performed before and after the 12 weeks in both groups. We assessed bone health by measuring parathyroid hormone (PTH), Ca, 25-OH vitamin D (25-OH vit D), 1,25-OH vitamin D (1,25-OH vit D), phosphate, alkaline phosphatase (ALP), and the bone turnover markers procollagen type 1 N-terminal propeptide (P1NP) and C-terminal telopeptide collagen type 1 (CTX-1). In addition, we examined the changes of sex hormones (estradiol, testosterone, luteinizing hormone, follicle-stimulating hormone), sex hormone-binding globulin, and leptin. Results After 12 weeks of MAD, we found a significant reduction in PTH, Ca, CTX-1, P1NP, 1,25-OH vit D, and leptin. There was a significant increase in 25-OH vit D. These changes were most pronounced among patients <37 years old, and in those patients with the highest body mass index (≥25.8 kg/m²), whereas sex and type of antiseizure medication had no impact on the results. For the reference group, the changes were nonsignificant for all the analyses. In addition, the changes in sex hormones were nonsignificant. Significance Twelve weeks of MAD treatment leads to significant changes in bone and Ca metabolism, with a possible negative effect on bone health as a result. A reduced level of leptin may be a triggering mechanism. The changes could be important for patients on MAD, and especially relevant for those patients who receive treatment with MAD at an early age before peak bone mass is reached.

• Mochol, Monika; Taubøll, Erik; Sveberg, Line; Tennøe, Bjørn; Olsen, Ketil Berg & Heuser, Kjell [Show all 7 contributors for this article] (2021). Seizure control after late introduction of anakinra in a patient with adult onset Rasmussen's encephalitis. Epilepsy and Behavior Reports (EBR). ISSN 2589-9864. 16. doi: 10.1016/j.ebr.2021.100462. Full text in Research Archive
• Mochol, Monika; Whatmore, Paul; Taubøll, Erik; Landmark, Cecilie Johannessen; Ropstad, Erik & Svalheim, Sigrid [Show all 7 contributors for this article] (2021). Lamotrigine effects on immune gene expression in larval zebrafish. Epilepsy Research. ISSN 0920-1211. 178, p. 1–8. doi: 10.1016/j.eplepsyres.2021.106823. Full text in Research Archive
• Heminghyt, Einar; Herrman, Helle; Skogan, Annette Holth; Konglund, Ane; Egge, Arild & Lossius, Morten Ingvar [Show all 8 contributors for this article] (2021). Cognitive change after DBS in refractory epilepsy: A randomized-controlled trial. Acta Neurologica Scandinavica. ISSN 0001-6314. p. 1–8. doi: 10.1111/ane.13539. Full text in Research Archive
• Hatlestad-Hall, Christoffer; Bruña, Ricardo; Erichsen, Erik Aksel Spendrup; Andersson, Vebjørn; Syvertsen, Marte Roa & Skogan, Annette Holth [Show all 13 contributors for this article] (2021). The organization of functional neurocognitive networks in focal epilepsy correlates with domain-specific cognitive performance. Journal of Neuroscience Research. ISSN 0360-4012. 99(10), p. 2669–2687. doi: 10.1002/jnr.24896. Full text in Research Archive
• Hatlestad-Hall, Christoffer; Bruña, Ricardo; Syvertsen, Marte Roa; Erichsen, Erik Aksel Spendrup; Andersson, Vebjørn & Vecchio, Fabrizio [Show all 12 contributors for this article] (2021). Source-level EEG and graph theory reveal widespread functional network alterations in focal epilepsy. Clinical Neurophysiology. ISSN 1388-2457. 132(7), p. 1663–1676. doi: 10.1016/j.clinph.2021.04.008. Full text in Research Archive
• Bjørke, Agnes Balint; Østby, Ylva; Grahl, Simon Gevert; Larsson, Pål Gunnar; Olsen, Ketil Berg & Nævra, Marianne C. Johansen [Show all 11 contributors for this article] (2021). Cognition in adult patients with newly diagnosed non-lesional temporal lobe epilepsy. Epilepsy & Behavior. ISSN 1525-5050. 116. doi: 10.1016/j.yebeh.2021.107771. Full text in Research Archive
• Pensel, Max C.; Nass, Robert Daniel; Taubøll, Erik; Aurlien, Dag & Surges, Rainer (2020). Prevention of sudden unexpected death in epilepsy: current status and future perspectives. Expert Review of Neurotherapeutics. ISSN 1473-7175. 20(5), p. 497–508. doi: 10.1080/14737175.2020.1754195. Full text in Research Archive
• Bjørk, Marte-Helene; Gerstner, Thorsten Alfons & Taubøll, Erik (2020). Treating women of reproductive age with valproate. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 2020(7), p. 1–6. doi: 10.4045/tidsskr.19.0767.
• Nome, Terje; Herrman, Helle; Lehtimäki, Kai; Egge, Arild; Konglund, Ane & Ramm-Pettersen, Jon-Terje [Show all 8 contributors for this article] (2020). Direct visual targeting versus preset coordinates for ANT-DBS in epilepsy. Acta Neurologica Scandinavica. ISSN 0001-6314. 142(1), p. 23–29. doi: 10.1111/ane.13233. Full text in Research Archive
• Berger, Toni; Vigeland, Magnus Dehli; Hjorthaug, Hanne Sagsveen; Nome, Cecilie; Taubøll, Erik & Selmer, Kaja Kristine [Show all 7 contributors for this article] (2020). Differential Glial Activation in Early Epileptogenesis—Insights From Cell-Specific Analysis of DNA Methylation and Gene Expression in the Contralateral Hippocampus. Frontiers in Neurology. ISSN 1664-2295. 11. doi: 10.3389/fneur.2020.573575. Full text in Research Archive
• Bjørk, Marte-Helene; Gerstner, Thorsten Alfons & Taubøll, Erik (2020). M.H. Bjørk og medarbeidere svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(9), p. 1–2. doi: 10.4045/tidsskr.20.0453. Full text in Research Archive
• Molteberg, Ellen; Thorsby, Per Medbøe; Kverneland, Magnhild; Iversen, Per Ole; Selmer, Kaja Kristine & Nakken, Karl Otto [Show all 7 contributors for this article] (2020). Effects of modified Atkins diet on thyroid function in adult patients with pharmacoresistant epilepsy. Epilepsy & Behavior. ISSN 1525-5050. 111:107285. doi: 10.1016/j.yebeh.2020.107285. Full text in Research Archive
• Mochol, Monika; Taubøll, Erik; Aukrust, Pål; Ueland, Thor; Andreassen, Ole Andreas & Svalheim, Sigrid (2020). Interleukin 18 (IL-18) and its binding protein (IL-18BP) are increased in patients with epilepsy suggesting low-grade systemic inflammation. Seizure. ISSN 1059-1311. 80, p. 221–225. doi: 10.1016/j.seizure.2020.05.018. Full text in Research Archive
• Gonzalez, Alba; Nome, Cecilie; Bendiksen, Bård Andre; Sjaastad, Ivar; Zhang, Lili & Aleksandersen, Mona [Show all 9 contributors for this article] (2020). Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy. Epilepsy Research. ISSN 0920-1211. 161, p. 1–7. doi: 10.1016/j.eplepsyres.2020.106300. Full text in Research Archive
• Berger, Toni; Vigeland, Magnus Dehli; Hjorthaug, Hanne Sagsveen; Etholm, Lars; Nome, Cecilie & Taubøll, Erik [Show all 8 contributors for this article] (2019). Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis. PLOS ONE. ISSN 1932-6203. 14:e0226575(12), p. 1–32. doi: 10.1371/journal.pone.0226575. Full text in Research Archive
• Kverneland, Magnhild; Taubøll, Erik; Molteberg, Ellen; Veierød, Marit Bragelien; Selmer, Kaja Kristine & Nakken, Karl Otto [Show all 7 contributors for this article] (2019). Pharmacokinetic interaction between modified Atkins diet and antiepileptic drugs in adults with drug-resistant epilepsy. Epilepsia. ISSN 0013-9580. 60, p. 2235–2244. doi: 10.1111/epi.16364. Full text in Research Archive
• Ulvin, Line Bédos; Taubøll, Erik; Olsen, Ketil Berg & Heuser, Kjell (2019). Predictive performances of STESS and EMSE in a Norwegian adult status epilepticus cohort. Seizure. ISSN 1059-1311. 70, p. 6–11. doi: 10.1016/j.seizure.2019.06.024.
• Herrman, Helle; Egge, Arild; Konglund, Ane; Ramm-Pettersen, Jon-Terje; Dietrichs, Espen & Taubøll, Erik (2018). Anterior thalamic deep brain stimulation in refractory epilepsy: A randomized, double-blinded study. Acta Neurologica Scandinavica. ISSN 0001-6314. 139(3), p. 294–304. doi: 10.1111/ane.13047. Full text in Research Archive
• Gonzalez Figuera, Alba Marina; Aurlien, Dag; Haugaa, Kristina & Taubøll, Erik (2018). Epilepsy in patients with long QT syndrome type 1: A Norwegian family. Epilepsy and Behavior Case Reports (EBCR). ISSN 2213-3232. 10, p. 118–121. doi: 10.1016/j.ebcr.2018.09.006. Full text in Research Archive Show summary

  The congenital long QT syndrome (cLQTS) is an inherited cardiac disorder and is associated with sudden cardiac death. We describe a Norwegian family with mutations within the KCNQ1 gene causing cLQTS type 1 (LQT1) and epilepsy. The index patient had Jervell and Lange-Nielsen-syndrome (JLNS) with deafness and recurrent episodes of cardiac arrhythmia. The mother and the brother have Romano-Ward syndrome (RWS) with recurrent arrhythmias. Whereas the father has focal epilepsy and genetically verified LQT1, the sister has both focal epilepsy and RWS. Our findings are consistent with the notion that mutations in the KCNQ1 gene can cause epilepsy.

• Heuser, Kjell; Nome, Cecilie; Pettersen, Klas; Åbjørsbråten, Knut Sindre; Jensen, Vidar & Tang, Wannan [Show all 10 contributors for this article] (2018). Ca2+ signals in astrocytes facilitate spread of epileptiform activity. Cerebral Cortex. ISSN 1047-3211. 28(11), p. 4036–4048. doi: 10.1093/cercor/bhy196. Full text in Research Archive
• Bjørke, Agnes Balint; Nome, Cecilie; Falk, Ragnhild Sørum; Gjerstad, Leif; Taubøll, Erik & Heuser, Kjell (2018). Evaluation of long-term antiepileptic drug use in patients with temporal lobe epilepsy: Assessment of risk factors for drug resistance and polypharmacy. Seizure. ISSN 1059-1311. 61, p. 63–70. doi: 10.1016/j.seizure.2018.07.011.
• Gonzalez Figuera, Alba Marina; Aurlien, Dag; Larsson, Pål Gunnar; Olsen, Ketil Berg; Dahl, Iselin Teresa & Edvardsen, Thor [Show all 8 contributors for this article] (2018). Seizure-like episodes and EEG abnormalities in patients with long QT syndrome. Seizure. ISSN 1059-1311. 61, p. 214–220. doi: 10.1016/j.seizure.2018.08.020.
• Ulvin, Line Bédos; Heuser, Kjell; Olsen, Ketil Berg & Taubøll, Erik (2018). Factors associated with refractoriness and outcome in an adult status epilepticus cohort. Seizure. ISSN 1059-1311. 61, p. 111–118. doi: 10.1016/j.seizure.2018.07.020.
• Kverneland, Magnhild; Molteberg, Ellen; Iversen, Per Ole; Veierød, Marit Bragelien; Taubøll, Erik & Selmer, Kaja Kristine [Show all 7 contributors for this article] (2018). Effect of modified Atkins diet in adults with drug-resistant focal epilepsy: A randomized clinical trial. Epilepsia. ISSN 0013-9580. 59(8), p. 1567–1576. doi: 10.1111/epi.14457.
• Heuser, Kjell; Nakken, Karl Otto; Sandvig, Inger & Taubøll, Erik (2016). Hva skyldes feberkramper? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(1), p. 36–38. doi: 10.4045/tidsskr.14.1503.
• Kwiecinska, Patrycja; Taubøll, Erik; Grzyb, Edyta; Fiedor, Elzbieta; Ptak, Anna & Gregoraszczuk, Ewa Lucja (2016). Valproic Acid as a Promising Co-Treatment with Paclitaxel and Doxorubicin in Different Ovarian Carcinoma Cell Lines. International Journal of Gynecological Cancer. ISSN 1048-891X. 26(9), p. 1546–1556. doi: 10.1097/IGC.0000000000000814.
• Aurlien, Dag; Gjerstad, Leif & Taubøll, Erik (2016). The role of antiepileptic drugs in sudden unexpected death in epilepsy. Seizure. ISSN 1059-1311. 43, p. 56–60. doi: 10.1016/j.seizure.2016.11.005.
• Lossius, Morten; Nakken, Karl Otto; Mowinckel, Petter; Taubøll, Erik & Gjerstad, Leif (2016). Favorable change of lipid profile after carbamazepine withdrawal. Acta Neurologica Scandinavica. ISSN 0001-6314. 134(3), p. 219–223. doi: 10.1111/ane.12534. Show summary

  Objective Patients treated with carbamazepine (CBZ) have increased serum levels of total cholesterol (TC), high-density lipoproteins (HDL), and low-density lipoproteins (LDL). We aimed to investigate whether these changes of serum lipids are reversible after CBZ withdrawal. Material and methods We used a prospective, randomized double-blinded design. A total of 160 patients who had been seizure free on anti-epileptic drug monotherapy for more than 2 years were included and randomized to withdrawal or not. The intervention was completed by 150 (80 females, 53%) patients. Serum samples from before and 4 months after completed withdrawal or no withdrawal were obtained from 130 patients (63 females, 48%). Of these, 84 were treated with CBZ, 28 with valproate, nine with phenytoin, four with phenobarbital, and five with lamotrigine. Of the patients who had been treated with CBZ, 47 were randomized to the withdrawal group, and 37 were randomized to the non-withdrawal group. Results Among the CBZ-treated patients, a significant decrease in serum levels of TC, LDL, and apolipoprotein B (ApoB) were found in the withdrawal group compared with the non-withdrawal group. Mean differences in change were as follows: TC 0.68 mmol/l (P = 0.005, CL – 1.15 to −0.21); LDL – 0.67 mmol/l (P = 0.001, CL – 1.03 to −0.29); ApoB – 0.13 g/l (P = 0.02, CL – 0.23 to −0.03). No significant changes in HDL, apolipoprotein A, and C-reactive protein were detected. Conclusion Our results indicate that CBZ may have unfavorable effects on serum levels of TC, LDL, and ApoB. However, these changes seem to be reversible even after years of treatment.

• Aurlien, Dag; Rath-Olsen, Trude; Taubøll, Erik; Gjerstad, Leif; Lossius, Morten & Nakken, Karl Otto (2016). Plutselig, uventet epilepsirelatert død. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(2), p. 131–135. doi: 10.4045/tidsskr.14.0640.
• Taubøll, Erik; Heuser, Kjell; Sveberg, Line & Svalheim, Sigrid (2015). Experimental models for the study of hormonal changes in epilepsy [Experimentelle Modelle zum Studium hormoneller Veränderungen bei Epilepsie]. Zeitschrift für Epileptologie. ISSN 1617-6782. 28(4), p. 246–253. doi: 10.1007/s10309-015-0001-x.
• Szokol, Karolina; Heuser, Kjell; Tang, Wannan; Jensen, Vidar; Enger, Rune & Bedner, Peter [Show all 10 contributors for this article] (2015). Augmentation of Ca&lt;sup&gt;2+&lt;/sup&gt; signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy. Frontiers in Cellular Neuroscience. ISSN 1662-5102. 9. doi: 10.3389/fncel.2015.00049. Full text in Research Archive Show summary

  Astrocytic endfeet are specialized cell compartments whose important homeostatic roles depend on their enrichment of water and ion channels anchored by the dystrophin associated protein complex (DAPC). This protein complex is known to disassemble in patients with mesial temporal lobe epilepsy and in the latent phase of experimental epilepsies. The mechanistic underpinning of this disassembly is an obvious target of future therapies, but remains unresolved. Here we show in a kainate model of temporal lobe epilepsy that astrocytic endfeet display an enhanced stimulation-evoked Ca(2+) signal that outlast the Ca(2+) signal in the cell bodies. While the amplitude of this Ca(2+) signal is reduced following group I/II metabotropic receptor (mGluR) blockade, the duration is sustained. Based on previous studies it has been hypothesized that the molecular disassembly in astrocytic endfeet is caused by dystrophin cleavage mediated by Ca(2+) dependent proteases. Using a newly developed genetically encoded Ca(2+) sensor, the present study bolsters this hypothesis by demonstrating long-lasting, enhanced stimulation-evoked Ca(2+) signals in astrocytic endfeet.

• Taubøll, Erik; Sveberg, Line & Svalheim, Sigrid (2015). Interactions between hormones and epilepsy. Seizure. ISSN 1059-1311. 28, p. 3–11. doi: 10.1016/j.seizure.2015.02.012.
• Svalheim, Sigrid; Sveberg, Line; Mochol, Monika & Taubøll, Erik (2015). Interactions between antiepileptic drugs and hormones. Seizure. ISSN 1059-1311. 28, p. 12–17. doi: 10.1016/j.seizure.2015.02.022.
• Sveberg, Line; Svalheim, Sigrid & Taubøll, Erik (2015). The impact of seizures on pregnancy and delivery. Seizure. ISSN 1059-1311. 28, p. 35–38. doi: 10.1016/j.seizure.2015.02.020.
• Hassel, Bjørnar; Elsais, Ahmed; Frøland, Anne-Sofie; Taubøll, Erik; Gjerstad, Leif & Quan, Yi [Show all 7 contributors for this article] (2015). Uptake and metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro. Journal of Neurochemistry. ISSN 0022-3042. 133(4), p. 572–581. doi: 10.1111/jnc.13079.
• Kverneland, Magnhild; Taubøll, Erik; Selmer, Kaja Kristine; Iversen, Per Ole & Nakken, Karl Otto (2015). Modified Atkins diet may reduce serum concentrations of antiepileptic drugs. Acta Neurologica Scandinavica. ISSN 0001-6314. 131(3), p. 187–190. doi: 10.1111/ane.12330.
• Hessel, Ellen VS; de Wit, Marina; Wolterink-Donselaar, Inge G; Karst, Henk; de Graaff, Esther & van Lith, Hein A [Show all 34 contributors for this article] (2014). Identification of Srp9 as a febrile seizure susceptibility gene. Annals of clinical and translational neurology. ISSN 2328-9503. 1(4), p. 239–250. doi: 10.1002/acn3.48.
• Nakken, Karl Otto; Lillestølen, Kari Mette; Brodtkorb, Eylert; Svendsen, Torleiv; Haggag, Kathrine J & Taubøll, Erik (2014). Antiepileptika og medfødte misdannelser. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(12-13), p. 1239–1242. doi: 10.4045/tidsskr.13.1349.
• Kwiecinska, Patrycja; Wróbel, Anna; Taubøll, Erik & Gregoraszczuk, Ewa Łucja (2014). Valproic acid, but not levetiracetam, selectively decreases HDAC7 and HDAC2 expression in human ovarian cancer cells. Toxicology Letters. ISSN 0378-4274. 224(2), p. 225–232. doi: 10.1016/j.toxlet.2013.10.035.
• Nakken, Karl Otto; Heuser, Kjell; Alfstad, Kristin Åshild & Taubøll, Erik (2014). Hvordan virker antiepileptika? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(1), p. 42–46. doi: 10.4045/tidsskr.13.0761.
• Heuser, Kjell; Szokol, Karolina & Taubøll, Erik (2014). Gliacellenes rolle ved epilepsi. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(1), p. 37–41. doi: 10.4045/tidsskr.12.1344.
• Haugaa, Kristina; Andersson, Stein; Vestervik, Tommy Tveit; Amlie, Jan Peder; Jørum, Ellen & Gjerstad, Leif [Show all 7 contributors for this article] (2013). Abnormal electroencephalograms in patients with long QT syndrome. Heart Rhythm. ISSN 1547-5271. 10(12), p. 1877–1883. doi: 10.1016/j.hrthm.2013.09.070.
• Svalheim, Sigrid; Mushtaq, Usman Ahmad; Mochol, Monika; Luef, G.; Rauchenzauner, M. & Frøland, Stig Sophus [Show all 7 contributors for this article] (2013). Reduced immunoglobulin levels in epilepsy patients treated with levetiracetam, lamotrigine, or carbamazepine. Acta Neurologica Scandinavica. ISSN 0001-6314. 127, p. 11–15. doi: 10.1111/ane.12044.
• Svalheim, Sigrid; Aurlien, Dag; Amlie, Jan Peder; Gjerstad, Leif & Taubøll, Erik (2012). Signal-averaged and standard electrocardiography in patients with newly diagnosed epilepsy. Epilepsy & Behavior. ISSN 1525-5050. 25(4), p. 543–545. doi: 10.1016/j.yebeh.2012.09.023.
• Kwiecinska, Patrycja; Taubøll, Erik & Gregoraszczuk, Ewa Lucja (2012). Comparison of the effects of valproic acid and levetiracetam on apoptosis in the human ovarian cancer cell line OVCAR-3. Pharmacological Reports. ISSN 1734-1140. 64(3), p. 603–614. doi: 10.1016/s1734-1140(12)70856-3.
• Aurlien, Dag; Larsen, Jan Petter; Gjerstad, Leif & Taubøll, Erik (2012). Comorbid and underlying diseases-Major determinants of excess mortality in epilepsy. Seizure. ISSN 1059-1311. 21(8), p. 573–577. doi: 10.1016/j.seizure.2012.05.015.
• Heuser, Kjell; Eid, Tore; Lauritzen, Fredrik; Thoren, Anna; Vindedal, Gry Fluge & Taubøll, Erik [Show all 11 contributors for this article] (2012). Loss of Perivascular Kir4.1 Potassium Channels in the Sclerotic Hippocampus of Patients With Mesial Temporal Lobe Epilepsy. Journal of Neuropathology and Experimental Neurology. ISSN 0022-3069. 71(9), p. 814–825. doi: 10.1097/NEN.0b013e318267b5af.
• Kwiecinska, Patrycja; Taubøll, Erik & Gregoraszczuk, Ewa L. (2012). Effects of valproic acid and levetiracetam on viability and cell cycle regulatory genes expression in the OVCAR-3 cell line. Pharmacological Reports. ISSN 1734-1140. 64(1), p. 157–165. doi: 10.1016/s1734-1140(12)70742-9.
• Aurlien, Dag; Larsen, Jan Petter; Gjerstad, Leif & Taubøll, Erik (2012). Increased risk of sudden unexpected death in epilepsy in females using lamotrigine: A nested, case-control study. Epilepsia. ISSN 0013-9580. 53(2), p. 258–266. doi: 10.1111/j.1528-1167.2011.03334.x.
• Svalheim, Sigrid; Røste, Line Sveberg; Nakken, Karl Otto & Taubøll, Erik (2011). Bone health in adults with epilepsy. Acta Neurologica Scandinavica. ISSN 0001-6314. 124, p. 89–95. doi: 10.1111/j.1600-0404.2011.01551.x.
• Bachmann, Tanja; Bertheussen, kjell h.; Svalheim, Sigrid; Rauchenzauner, M.; Luef, G. & Gjerstad, Leif [Show all 7 contributors for this article] (2011). Haematological side effects of antiepileptic drug treatment in patients with epilepsy. Acta Neurologica Scandinavica. ISSN 0001-6314. 124, p. 23–27. doi: 10.1111/j.1600-0404.2011.01539.x.
• Heuser, Kjell; Cvancarova, Milada; Gjerstad, Leif & Taubøll, Erik (2011). Is Temporal Lobe Epilepsy with childhood febrile seizures a distinctive entity? A comparative study. Seizure. ISSN 1059-1311. 20(2), p. 163–166. doi: 10.1016/j.seizure.2010.11.015.
• Hassel, Bjørnar; Taubøll, Erik; Shaw, Renee; Gjerstad, Leif & Dingledine, Ray (2010). Region-specific changes in gene expression in rat brain after chronic treatment with levetiracetam or phenytoin. Epilepsia. ISSN 0013-9580. 51(9), p. 1714–1720. doi: 10.1111/j.1528-1167.2010.02545.x.
• von Krogh, Kristine; Harjen, Hannah; Almås, Camilla; Ropstad, Erik; Taubøll, Erik & Olsaker, Ingrid [Show all 9 contributors for this article] (2010). The effect of valproate and levetiracetam on steroidogenesis in forskolin-stimulated H295R cells. Epilepsia. ISSN 0013-9580. 51(11), p. 2280–2288. doi: 10.1111/j.1528-1167.2010.02702.x.
• Nakken, Karl Otto & Taubøll, Erik (2010). Bone loss associated with use of antiepileptic drugs. Expert Opinion on Drug Safety. ISSN 1474-0338. 9(4), p. 561–571. doi: 10.1517/14740331003636475.
• Heuser, Kjell; Hoddevik, Eystein Hellstrøm; Taubøll, Erik; Gjerstad, Leif; Indahl, Ulf Geir & Kaczmarek, L [Show all 10 contributors for this article] (2010). Temporal Lobe Epilepsy and Matrix Metalloproteinase 9: A tempting relation but negative genetic association. Seizure. ISSN 1059-1311. 19(6), p. 335–338. doi: 10.1016/j.seizure.2010.05.003.
• Heuser, Kjell; Nagelhus, Erlend Arnulf; Taubøll, Erik; Indahl, Ulf Geir; Berg, Paul Ragnar & Lien, Sigbjørn [Show all 9 contributors for this article] (2010). Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. Epilepsy Research. ISSN 0920-1211. 88(1), p. 55–64. doi: 10.1016/j.eplepsyres.2009.09.023.
• Svalheim, Sigrid; Luef, G; Rauchenzauner, M; Mørkrid, Lars; Gjerstad, Leif & Taubøll, Erik (2010). Cardiovascular risk factors in epilepsy patients taking levetiracetam, carbamazepine or lamotrigine. Acta Neurologica Scandinavica. ISSN 0001-6314. 122, p. 30–33.
• Sætre, Erik Rolvsson; Abdelnoor, Michael; Perucca, Emilio; Taubøll, Erik; Isojärvi, Jouko I.T. & Gjerstad, Leif (2010). Antiepileptic drugs and quality of life in the elderly: Results from a randomized double-blind trial of carbamazepine and lamotrigine in patients with onset of epilepsy in old age. Epilepsy & Behavior. ISSN 1525-5050. 17(3), p. 395–401. doi: 10.1016/j.yebeh.2009.12.026.
• Rauchenzauner, Markus; Bitsche, Gabriele; Svalheim, Sigrid; Taubøll, Erik; Haberlandt, Edda & Wildt, Ludwig [Show all 8 contributors for this article] (2010). Effects of levetiracetam and valproic acid monotherapy on sex-steroid hormones in prepubertal children-Results from a pilot study. Epilepsy Research. ISSN 0920-1211. 88(2-3), p. 264–268. doi: 10.1016/j.eplepsyres.2009.11.003.
• Gustavsen, Marte Wendel; von Krogh, Kristine; Taubøll, Erik; Zimmer, Karin; Dahl, Ellen & Olsaker, Ingrid [Show all 8 contributors for this article] (2009). Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurologica Scandinavica. ISSN 0001-6314. 120, p. 14–21. doi: 10.1111/j.1600-0404.2009.01206.x.
• Gustavsen, M.W.; von Krogh, Kristine; Taubøll, Erik; Zimmer, Karin E.; Dahl, Ellen & Olsaker, Ingrid [Show all 8 contributors for this article] (2009). Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurologica Scandinavica, Supplementum. ISSN 0065-1427. 120(suppl 189), p. 14–21.
• Aurlien, D; Leren, Tron P; Taubøll, Erik & Gjerstad, Leif (2009). New SCN5A mutation in a SUDEP victim with idiopathic epilepsy. Seizure. ISSN 1059-1311. 18(2), p. 158–160. doi: 10.1016/j.seizure.2008.07.008.
• Heuser, Kjell; Taubøll, Erik; Nagelhus, Erlend Arnulf; Småstuen, Milada C; Ottersen, Ole Petter & Gjerstad, Leif (2009). Phenotypic characteristics of temporal lobe epilepsy: the impact of hippocampal sclerosis. Acta Neurologica Scandinavica. ISSN 0001-6314. 120, p. 8–13.
• Sætre, Erik; Abdelnoor, Michael; Amlie, Jan Peder; Tøssebro, Morten Støren; Perucca, E & Taubøll, Erik [Show all 9 contributors for this article] (2009). Cardiac function and antiepileptic drug treatment in the elderly: A comparison between lamotrigine and sustained-release carbamazepine. Epilepsia. ISSN 0013-9580. 50(8), p. 1841–1849. doi: 10.1111/j.1528-1167.2009.02069.x.
• Kostov, Konstatin; Kostov, Hrisimir & Taubøll, Erik (2009). Long-term vagus nerve stimulation in the treatment of Lennox-Gastaut syndrome. Epilepsy & Behavior. ISSN 1525-5050. 16(2), p. 321–324. doi: 10.1016/j.yebeh.2009.07.038.
• Lossius, Morten; Taubøll, Erik; Mowinckel, Petter & Gjerstad, Leif (2009). Reversible effects of antiepileptic drugs on thyroid hormones in men and women with epilepsy: A prospective randomized double-blind withdrawal study. Epilepsy & Behavior. ISSN 1525-5050. 16(1), p. 64–68. doi: 10.1016/j.yebeh.2009.07.014.

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• Horn, Morten Andreas; Hov, Maren Ranhoff; Heuser, Kjell & Taubøll, Erik (2023). Tid til kontroll som kvalitetsmål ved håndtering av kramper. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 143(9). doi: 10.4045/tidsskr.23.0230.
• Horn, Morten Andreas; Hov, Maren Ranhoff; Heuser, Kjell & Taubøll, Erik (2023). Time To Control—A goal in seizure management. Seizure. ISSN 1059-1311. 106. doi: 10.1016/j.seizure.2023.02.008.
• Storvig, Gøril; Sødal, Hild Flatmark; Robinson, Hilde Stendal; Tverdal, Cathrine Buaas; Helseth, Eirik & Taubøll, Erik (2022). Tidlig post-traumatiske epileptiske anfall hos pasienter med traumatisk hjerneskade.
• Aamodt, Anne Hege; Taubøll, Erik; Ele, Tom Eich; Romundstad, Luis Georg; Sorteberg, Angelika & Wallace, Sean Ciaran [Show all 24 contributors for this article] (2021). Brain monitoring in hospitals needs to be strengthened. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(15), p. 1–8. doi: 10.4045/tidsskr.21.0412.
• Habhab, Sarah Folkestad; Ulvin, Line Bédos; Taubøll, Erik; Svalheim, Sigrid; Olsen, Ketil Berg & Horn, Morten Andreas [Show all 7 contributors for this article] (2020). Influence of valproate-induced hyperammonemia on treatment decision in an adult status epilepticus cohort. Epilepsy & Behavior. ISSN 1525-5050. 111. doi: 10.1016/j.yebeh.2020.107193.
• Gonzalez, Alba; Aurlien, Dag; Larsson, Pål Gunnar; Olsen, Ketil Berg; Dahl, Iselin Teresa & Edvardsen, Thor [Show all 8 contributors for this article] (2019). Corrigendum to “Seizure-like episodes and EEG abnormalities in patients with long QT syndrome” (Seizure: European Journal of Epilepsy (2018) 61 (214–220), (S1059131118303662), (10.1016/j.seizure.2018.08.020)). Seizure. ISSN 1059-1311. 69. doi: 10.1016/j.seizure.2018.12.002.
• Kverneland, Magnhild; Selmer, Kaja Kristine; Nakken, Karl Otto; Iversen, Per Ole & Taubøll, Erik (2015). A prospective study of the modified Atkins diet for adults with idiopathic generalized epilepsy. Epilepsy & Behavior. ISSN 1525-5050. 53, p. 197–201. doi: 10.1016/j.yebeh.2015.10.021.
• Taubøll, Erik & luef, gerhard (2015). Gender issues in epilepsy - difference in management of epilepsy. Seizure. ISSN 1059-1311. 28, p. 1–2.
• Sveberg, Line; Vik, Kristin; Henriksen, Tore & Taubøll, Erik (2015). Women with epilepsy and post partum bleeding - Is there a role for vitamin K supplementation? Seizure. ISSN 1059-1311. 28, p. 85–87. doi: 10.1016/j.seizure.2015.02.021.
• Vik-Mo, Einar O.; Krossnes, Bård Kronen; Stanisic, Milo; Egge, Arild; Holter, Ellen & Taubøll, Erik [Show all 8 contributors for this article] (2014). Reactivation of occult herpes simplex meningoencephalitis after temporal lobe resection for refractory epilepsy - A case report. Seizure. ISSN 1059-1311. 23(4), p. 321–323. doi: 10.1016/j.seizure.2014.01.010.
• Nakken, Karl Otto & Taubøll, Erik (2014). Valproat bør unngås hos gravide. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 134(2), p. 144–145. doi: 10.4045/tidsskr.13.1350.
• Aurlien, Dag; Larsen, Jan Petter; Gjerstad, Leif & Taubøll, Erik (2012). Consistent message? Epilepsia. ISSN 0013-9580. 53(5), p. 929–930. doi: 10.1111/j.1528-1167.2012.03461.x.
• Taubøll, Erik (2010). Disorders of reproduction in epilepsy. European Journal of Neurology. ISSN 1351-5101. 17(supp. 3), p. 630–630.
• Engelsen, Bernt & Taubøll, Erik (2016). Behandling av status epileptikus hos voksne. Oslo universitetssykehus HF.
• Henriksen, Tore; Kampman, Margitta T.; Nakken,, Karl Otto; Braathen, Geir J.; Gjerstad,, Leif & Husby., Henrik [Show all 12 contributors for this article] (2012). Epilepsi og svangerskap. I: Retningslinjer for behandling av kvinner med epilepsi. Cappelen Damm Høyskoleforlaget. ISSN 0029-2001.
• Svalheim, Sigrid & Taubøll, Erik (2010). Epilepsy, hormones and antiepileptic drugs. Unipub forlag.

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