Gro Owren Nygaard

• Nygaard, Gro Owren & Holmøy, Trygve (2024). Norsk helsevesen børtilby stamcellebehandling mot multippel sklerose. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 144(2). doi: 10.4045/tidsskr.23.0770.
• Wolf, Asia-Sophia Fumika Michaela; Ravussin, Anthony; König, Marton; Øverås, Mathias Herstad; Solum, Guri & Kjønstad, Ingrid Fadum [Show all 18 contributors for this article] (2023). T cell responses to SARS-CoV-2 vaccination differ by disease-modifying therapy for multiple sclerosis. JCI Insight. ISSN 2379-3708. 8(12), p. 1–14. doi: 10.1172/jci.insight.165111. Full text in Research Archive
• Tran, Trung; Vaage, Eline Benno; Mehta, Adi; Chopra, Adity; Tietze, Lisa & Kolderup, Heidi Anette [Show all 40 contributors for this article] (2022). Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants. npj Vaccines. ISSN 2059-0105. 7(1). doi: 10.1038/s41541-022-00586-7. Full text in Research Archive
• König, Marton; Torgauten, Hilde Marie; Tran, Trung; Holmøy, Trygve; Vaage, John T. & Lund-Johansen, Fridtjof [Show all 7 contributors for this article] (2022). Immunogenicity and Safety of a Third SARS-CoV-2 Vaccine Dose in Patients with Multiple Sclerosis and Weak Immune Response after COVID-19 Vaccination. JAMA Neurology. ISSN 2168-6149. 79(3), p. 307–309. doi: 10.1001/jamaneurol.2021.5109.
• Riise, Jon; Meyer, Saskia; Blaas, Isaac; Chopra, Adity; Tran, Trung & Delic-Sarac, Marina [Show all 22 contributors for this article] (2022). Rituximab-treated patients with lymphoma develop strong CD8 T-cell responses following COVID-19 vaccination. British Journal of Haematology. ISSN 0007-1048. 197(6), p. 697–708. doi: 10.1111/bjh.18149. Full text in Research Archive Show summary

  B-cell depletion induced by anti-cluster of differentiation 20 (CD20) monoclonal antibody (mAb) therapy of patients with lymphoma is expected to impair humoral responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination, but effects on CD8 T-cell responses are unknown. Here, we investigated humoral and CD8 T-cell responses following two vaccinations in patients with lymphoma undergoing anti-CD20-mAb therapy as single agent or in combination with chemotherapy or other anti-neoplastic agents during the last 9 months prior to inclusion, and in healthy age-matched blood donors. Antibody measurements showed that seven of 110 patients had antibodies to the receptor-binding domain of the SARS-CoV-2 Spike protein 3–6 weeks after the second dose of vaccination. Peripheral blood CD8 T-cell responses against prevalent human leucocyte antigen (HLA) class I SARS-CoV-2 epitopes were determined by peptide-HLA multimer analysis. Strong CD8 T-cell responses were observed in samples from 20/29 patients (69%) and 12/16 (75%) controls, with similar median response magnitudes in the groups and some of the strongest responses observed in patients. We conclude that despite the absence of humoral immune responses in fully SARS-CoV-2-vaccinated, anti-CD20-treated patients with lymphoma, their CD8 T-cell responses reach similar frequencies and magnitudes as for controls. Patients with lymphoma on B-cell depleting therapies are thus likely to benefit from current coronavirus disease 2019 (COVID-19) vaccines, and development of vaccines aimed at eliciting T-cell responses to non-Spike epitopes might provide improved protection.

• König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, Trung; Schikora-Rustad, Stine & Vaage, Eline Benno [Show all 22 contributors for this article] (2021). Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations. Journal of Neurology, Neurosurgery and Psychiatry. ISSN 0022-3050. doi: 10.1136/jnnp-2021-327612. Full text in Research Archive
• Høgestøl, Einar August; Ghezzo, Samuele; Nygaard, Gro Owren; Espeseth, Thomas; Sowa, Piotr & Beyer, Mona K. [Show all 10 contributors for this article] (2021). Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study. Multiple Sclerosis. ISSN 1352-4585. p. 1–9. doi: 10.1177/13524585211030212. Full text in Research Archive
• Brune, Synne; Høgestøl, Einar August; Cengija, Vanja; Berg-Hansen, Pål; Sowa, Piotr & Nygaard, Gro Owren [Show all 8 contributors for this article] (2020). LesionQuant for assessment of MRI in multiple sclerosis—A promising supplement to the visual scan inspection. Frontiers in Neurology. ISSN 1664-2295. 11:546744, p. 1–10. doi: 10.3389/fneur.2020.546744. Full text in Research Archive
• Høgestøl, Einar August; Kaufmann, Tobias; Nygaard, Gro Owren; Beyer, Mona K.; Sowa, Piotr & Nordvik, Jan Egil [Show all 11 contributors for this article] (2019). Cross-sectional and longitudinal MRI brain scans reveal accelerated brain aging in multiple sclerosis. Frontiers in Neurology. ISSN 1664-2295. 10:450, p. 1–9. doi: 10.3389/fneur.2019.00450. Full text in Research Archive
• Benavent, Sigrid Aune de Rodez; Nygaard, Gro Owren; Nilsen, Kristian Bernhard; Etholm, Lars; Sowa, Piotr & Gustavsen, Marte Wendel [Show all 11 contributors for this article] (2019). Neurodegenerative interplay of cardiovascular autonomic dysregulation and the retina in early multiple sclerosis. Frontiers in Neurology. ISSN 1664-2295. 10, p. 1–9. doi: 10.3389/fneur.2019.00507. Full text in Research Archive
• Høgestøl, Einar August; Nygaard, Gro Owren; Alnæs, Dag; Beyer, Mona K.; Westlye, Lars Tjelta & Harbo, Hanne Flinstad (2019). Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis. PLOS ONE. ISSN 1932-6203. 14(4). doi: 10.1371/journal.pone.0210375. Full text in Research Archive
• Lindland, Elisabeth Margrete Stokke; Solheim, Anne Marit; Andreassen, Silje; Paulsen, Else Quist; Eikeland, Randi & Ljøstad, Unn [Show all 12 contributors for this article] (2018). Imaging in Lyme neuroborreliosis. Insight into Imaging. ISSN 1869-4101. 9(5), p. 833–844. doi: 10.1007/s13244-018-0646-x. Full text in Research Archive
• Sowa, Piotr; Nygaard, Gro Owren; Bjørnerud, Atle; Celius, Elisabeth Gulowsen; Harbo, Hanne Flinstad & Beyer, Mona K. (2017). Magnetic resonance imaging perfusion is associated with disease severity and activity in multiple sclerosis. Neuroradiology. ISSN 0028-3940. 59(7), p. 655–664. doi: 10.1007/s00234-017-1849-4. Full text in Research Archive
• de Rodez Benavent, Sigrid Aune; Nygaard, Gro Owren; Harbo, Hanne Flinstad; Tønnesen, Siren; Sowa, Piotr & Landrø, Nils Inge [Show all 13 contributors for this article] (2017). Fatigue and cognition: Pupillary responses to problem-solving in early multiple sclerosis patients. Brain and Behavior. ISSN 2162-3279. 7. doi: 10.1002/brb3.717. Full text in Research Archive
• Gustavsen, Marte Wendel; Celius, Elisabeth Gulowsen; Winsvold, Bendik K S; Moen, Stine Marit; Nygaard, Gro Owren & Berg-Hansen, Pål [Show all 9 contributors for this article] (2016). Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study. Multiple Sclerosis Journal, Experimental, Translational and Clinical. ISSN 2055-2173. 2, p. 1–4. doi: 10.1177/2055217316682976. Full text in Research Archive
• Sowa, Piotr; Bjørnerud, Atle; Nygaard, Gro Owren; Damangir, Soheil; Spulber, Gabriela & Celius, Elisabeth Gulowsen [Show all 9 contributors for this article] (2015). Reduced perfusion in white matter lesions in multiple sclerosis. European Journal of Radiology. ISSN 0720-048X. 84(12), p. 2605–2612. doi: 10.1016/j.ejrad.2015.09.007.
• Nygaard, Gro Owren; Celius, Elisabeth Gulowsen; de Rodez Benavent, Sigrid Aune; Sowa, Piotr; Gustavsen, Marte Wendel & Fjell, Anders Martin [Show all 9 contributors for this article] (2015). A longitudinal study of disability, cognition and gray matter atrophy in early multiple sclerosis patients according to evidence of disease activity. PLOS ONE. ISSN 1932-6203. 10(8). doi: 10.1371/journal.pone.0135974. Full text in Research Archive
• Nygaard, Gro Owren; de Rodez Benavent, Sigrid Aune; Harbo, Hanne Flinstad; Laeng, Bruno; Sowa, Piotr & Damangir, Soheil [Show all 13 contributors for this article] (2015). Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis. Multiple Sclerosis and Related Disorders. ISSN 2211-0348. 4(6), p. 585–589. doi: 10.1016/j.msard.2015.08.003.
• Nygaard, Gro Owren; Walhovd, Kristine B; Sowa, Piotr; Chepkoech, Joy-Loi; Bjørnerud, Atle & Due-Tønnessen, Paulina [Show all 14 contributors for this article] (2015). Cortical thickness and surface area relate to specific symptoms in early relapsing−remitting multiple sclerosis. Multiple Sclerosis. ISSN 1352-4585. 21(4), p. 402–414. doi: 10.1177/1352458514543811.
• Gustavsen, Marte Wendel; Page, Christian; Moen, Stine Marit; Bjølgerud, Anja; Berg-Hansen, Pål & Nygaard, Gro Owren [Show all 10 contributors for this article] (2014). Environmental exposures and the risk of multiple sclerosis investigated in a Norwegian case-control study. BMC Neurology. ISSN 1471-2377. 14(1). doi: 10.1186/s12883-014-0196-x. Full text in Research Archive
• Fremeau, R.T Jr; Troyer, M. D.; Pahner, I; Nygaard, Gro Owren; Tran, C. H. & Reimer, R.J. [Show all 10 contributors for this article] (2001). The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron. ISSN 0896-6273. 31(2), p. 247–260.

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• Skattebøl, Lars; Øverås, Mathias Herstad; Nordhøy, Wibeke; Harbo, Hanne Flinstad; Sowa, Piotr & Lundby, Rigmor [Show all 8 contributors for this article] (2023). Brain Age and Quantitative Susceptibility Mapping of Chronic Active Lesions in Relapsing Multiple Sclerosis.
• Tran, Trung; Vaage, Eline Benno; Mehta, Adi; Chopra, Adity; Tietze, Lisa & Kolderup, Heidi Anette [Show all 40 contributors for this article] (2023). Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants (npj Vaccines, (2022), 7, 1, (174), 10.1038/s41541-022-00586-7). npj Vaccines. ISSN 2059-0105. 8(1). doi: 10.1038/s41541-023-00600-6.
• Skattebøl, Lars; Nygaard, Gro Owren; Sowa, Piotr; Olsrud, Ellen Regine & Nordhøy, Wibeke (2022). Clinical integration of an automated QSM pipeline for multiple sclerosis on a 3 T MRI.
• Rasmussen, Tilde; König, Marton; Lorentzen, Åslaug Rudjord; Schikora-Rustad, Stine; Berge, Tone & Holmøy, Trygve [Show all 17 contributors for this article] (2022). Safety of a third SARS CoV 2 mRNA vaccine dose in people with multiple sclerosis.
• König, Marton; Wolf, Asia-Sophia Fumika Michaela; Ravussin, Anthony; Chopra, Adity; Tran, Trung & Torgauten, Hilde Marie [Show all 28 contributors for this article] (2022). Immunogenicity and efficacy of mRNA-COVID-19 vaccines in people with multiple sclerosis.
• Nygaard, Gro Owren; Torgauten, Hilde Marie; Skattebøl, Lars; Høgestøl, Einar August; Sowa, Piotr & Myhr, Kjell-Morten [Show all 8 contributors for this article] (2022). Risk of fingolimod rebound after switching to cladribine or rituximab in multiple sclerosis. Multiple Sclerosis and Related Disorders. ISSN 2211-0348. 62. doi: 10.1016/j.msard.2022.103812.
• Nygaard, Gro Owren; Schikora-Rustad, Stine; Lie, Ingeborg Haugesag; Aase, Audun; Leiknes, Ingvild Jullum & König, Marton [Show all 15 contributors for this article] (2021). Humoral immune response to the influenza vaccine in multiple sclerosis patients treated with cladribine or rituximab.
• König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, The Trung; Schikora-Rustad, Stine & Vaage, Eline Benno [Show all 22 contributors for this article] (2021). Humoral Immunity to SARS-CoV-2 mRNA Vaccination in People with Multiple Sclerosis using High-Efficacy Disease Modifying Therapies.
• Nygaard, Gro Owren (2017). Hjerneslag i sykehus. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(19), p. 1–1. doi: 10.4045/tidsskr.17.0634.
• Moen, Stine Marit; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Sowa, Piotr; Nygaard, Gro Owren & Beyer, Mona K. (2016). S.M. Moen og medarbeidere svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(19), p. 1608–1608. doi: 10.4045/tidsskr.16.0826.
• Moen, Stine Marit; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Sowa, Piotr; Nygaard, Gro Owren & Beyer, Mona K. (2016). S.M. Moen og medarbeidere svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(20), p. 1702–1702. doi: 10.4045/tidsskr.16.0865.
• Moen, Stine Marit; Harbo, Hanne Flinstad; Sowa, Piotr; Celius, Elisabeth Gulowsen; Nygaard, Gro Owren & Beyer, Mona K. (2016). MR-undersøkelser ved multippel sklerose. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 136(16), p. 1373–1376. doi: 10.4045/tidsskr.15.1361.
• Gustavsen, Marte Wendel; Celius, Elisabeth Gulowsen; Moen, Stine Marit; Bjølgerud, Anja; Berg-Hansen, Pål & Nygaard, Gro Owren [Show all 9 contributors for this article] (2015). No association between multiple sclerosis and periodontitis after adjusting for smoking habits. European Journal of Neurology. ISSN 1351-5101. 22(3), p. 588–590. doi: 10.1111/ene.12520.
• Nygaard, Gro Owren; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen & Landro, N. I. (2013). Does the Brief International Cognitive Assessment for MS (BICAMS) catch the cognitive problems of a sample of well-educated recently diagnosed MS patients in Oslo? Multiple Sclerosis. ISSN 1352-4585. 19(7), p. 970–971.
• Benavent, S.A. de Rodez; Nygaard, Gro Owren; Tønnesen, Siren; Celius, Elisabeth Gulowsen; Landro, N. I. & Laeng, Bruno (2013). Pupillometry indicates increased cognitive effort in response to easy cognitive tasks in newly diagnosed MS patients. Multiple Sclerosis. ISSN 1352-4585. 19(7), p. 988–989.

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