Gunnar Andreas Husby

• Omdal, Roald; Sjøholm, Hans; Sjoholm, Hans; Koldingsnes, Wenche; Sundsfjord, Johan A & Jacobsen, Eva A. [Show all 8 contributors for this article] (2005). Fatigue in patients with lupus is not associated with disturbances in cerebral blood flow as detected by SPECT. Journal of Neurology. ISSN 0340-5354. 252, p. 78–83.
• Sorby, R; Wien, Tale Norbye; Husby, Gunnar Andreas; Espenes, A & Landsverk, T (2005). Filter function and immune complex trapping in splenic ellipsoids. Journal of Comparative Pathology. ISSN 0021-9975. 132.
• Gran, Jan Tore & Husby, Gunnar Andreas (2004). Seronegative polyarthritis including Adult Still's Disease. In Koopman, WJ. & Moreland, LW (Ed.), Arthritis and Allied Conditions: A Textbook of Rheumatology. 15th ed. Lippincott William & Wilkins. ISSN 0-7817-4671-X.
• Omtvedt, Lone Aanerud; Wien, Tale Norbye; Myran, Theresa; Sletten, Knut & Husby, Gunnar Andreas (2004). Serum amyloid P component in mink, a non-glycosylated protein with affinity for phosphorylethanolamine and phosphorylcholine. Amyloid: Journal of Protein Folding Disorders. ISSN 1350-6129. 11(2), p. 101–108.
• Wien, Tale Norbye; Sørby, R.; Omtvedt, Lone Aanerud; Landsverk, T. & Husby, Gunnar Andreas (2004). Kinetics of Glycosaminoglycan Deposition in Splenic AA Amyloidosis Induced in Mink. Scandinavian Journal of Immunology. ISSN 0300-9475. 60, p. 600–608.
• Elisen, E J.; Bruun, F. C.; Nordstoga, Knut; Husby, Gunnar Andreas & Sletten, Knut (2004). Serum amyloid A protein forms a complex with a fragment of apolipoprotein A-I in the domestic blue fox: a protective mechanism against AA amyloidosis? Amyloid: Journal of Protein Folding Disorders. ISSN 1350-6129. 11(3), p. 184–190.
• Myran, Theresa; Husby, Gunnar Andreas; Kyle, RA. & Sletten, Knut (2004). The amino acid sequence of a glycosylated AL-chain from a patient with primary amyloidosis. Amyloid: Journal of Protein Folding Disorders. ISSN 1350-6129. 11(2), p. 109–112.
• Thompson, Keith; Sletten, Knut; Brandtzæg, Per; Kallberg, Eva; Wien, Tale Norbye & Husby, Gunnar Andreas (2003). Articular, monoclonal gamma3 heavy-chain deposition disease: characterization of a partially deleted heavy-chain gene and its protein product synthesized in vivo and in vitro. Arthritis and Rheumatism. ISSN 0004-3591. 48(11), p. 3266–3271. Show summary

  OBJECTIVE: A patient presented with heavy-chain deposition disease (HCDD), exhibiting severe erosive polyarthropathy caused by synovial deposits of abnormal monoclonal, heavily deleted free gamma3 heavy chains lacking the V(H) and C(H)1 domains. The absence of V(H) was surprising, since it is considered important for pathogenic tissue deposition. This study was undertaken to analyze the genetic structure of the heavy chain, the protein product synthesized in vitro, and that deposited in the synovium in comparison with the serum and urinary proteins. METHODS: Hybridomas were made by fusion of blood and bone marrow mononuclear cells with mouse myeloma cells. Cloned B cell hybridomas secreting gamma3 were selected and analyzed by polymerase chain reaction. Purified hybridoma Ig was sequenced by Edman degradation. Antiserum raised to a peptide corresponding to residues 2-15 of the truncated V(H) was used in Western blots of synovial tissue. RESULTS: The hybridomas secreted free gamma3 chains consisting of a V(H)4 gene truncated 21 nucleotides into the first complementarity-determining region and then reading straight into the hinge region. The amino acid sequence confirmed the presence of residues 1-32 of the V(H)4 gene. Immunoblotting of synovial tissue showed the presence of Ig with truncated V(H). CONCLUSION: The gamma3 heavy chain had a deletion of V(H) from codon 33 and of the entire C(H)1. In vivo, the 32 V(H) amino acids were proteolytically degraded. In the joint, however, the 32 residues of V(H) remained intact, consistent with a pathogenic role of V(H) for tissue deposition. To our knowledge, this is the first reported case of gammaHCDD causing an erosive, polyarticular arthropathy as the dominating clinical feature

• Omdal, Roald; Waterloo, Knut; Husby, Gunnar Andreas & Mellgren, Svein Ivar (2003). Fatigue in patients with systemic lupus erythematosus: the psychosocial aspects. Journal of Rheumatology. ISSN 0315-162X. 30(2), p. 283–287.
• Wien, Tale Norbye; Sørby, R.; Espenes, A.; Gunnes, G.; Nordstoga, Knut & Landsverk, T. [Show all 7 contributors for this article] (2003). Splenic ellipsoids: an early target for deposition of AA amyloid induced in mink. Amyloid: Journal of Protein Folding Disorders. ISSN 1350-6129. 10, p. 240–249.
• Omdal, Roald; Waterloo, Knut K; Koldingsnes, Wenche; Husby, Gunnar & Mellgren, Svein Ivar (2003). Fatigue in patients with systemic lupus erythematosus: the psychosocial aspects. Journal of Rheumatology. ISSN 0315-162X. 30(2), p. 283–287.
• Aarset, Harald; Dekker, Joost; Brorson, Sverre Henning & Husby, Gunnar Andreas (2002). Crystal-induced arthritis mimicking rheumatoid arthritis in a patient with monoclonal gammopathy. Arthritis and Rheumatism. ISSN 0004-3591. 46(10), p. 2816–2816. Show summary

  The patient, a 57-year-old man, presented with seronegative, erosive polyarthritis. The small joints of the hands and feet were initially affected, followed by the development of arthritis in the ankles, knees, and elbows, and accompanied by ecchymoses and bullae on both feet. Serum analysis demonstrated a cryoprecipitable and crystal-forming IgG (M-component), and immunohistochemistry analysis of a bone marrow biopsy specimen showed a small increase in monoclonal plasma cells positive for IgG. Synovial biopsy of a metacarpophalangeal joint revealed severe crystal synovitis with fibrinoid material and infiltration by lymphocytes, plasma cells, neutrophil granulocytes, and histiocytes. In the fibrinoid material and superficially in the synovial tissue there were many crystals of different shapes and sizes; some were rhomboid or rectangular (above). Electron microscopic investigation revealed that the crystals had a homogeneous structure consistent with a proteinaceous composition, and immunoelectron microscopy demonstrated the presence of IgG. The deposition of crystals in various organs, including joints, is a rare manifestation of cryoglobulinemia.

• Husby, Gunnar Andreas; Brandtzæg, Per; Mellbye, Ove J.; Thompson, Keith; Sletten, Knut & Aarset, Harald (2002). Protein deposition diseases: when structurally altered proteins assemble out of place. With special emphasis on monoclonal immunoglobulin deposition disease causing erosive polyarthropathy. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 31, p. 60–65.
• Waterloo, Knut; Omdal, Roald; Husby, Gunnar Andreas & Mellgren, Svein Ivar (2002). Neuropsychological function in systemic lupus erythematosus; a five-year longitudinal study. Rheumatology (Sveits). ISSN 0080-2727. 41, p. 411–415.
• Omdal, Roald; Mellgren, Svein Ivar; Gøransson, L.; Skjesol, A.; Lindal, S. & Koldingsnes, Wenche [Show all 7 contributors for this article] (2002). Small nerve fiber involvement in systemic lupus erythematosus. Arthritis and Rheumatism. ISSN 0004-3591. 46(5), p. 1228–1232.
• Waterloo, Knut K; Omdal, Roald; Husby, Gunnar & Mellgren, Svein Ivar (2002). Neuropsychological function in systemic lupus erythematosus: five-year longitudinal study. Rheumatology (Sveits). ISSN 0080-2727. 41(4), p. 411–415.
• Omdal, Roald; Mellgren, Svein Ivar; Gøransson, Lasse; Skjesol, Astrid; Lindal, Sigurd & Koldingsnes, Wenche [Show all 7 contributors for this article] (2002). Small Nerve Fiber Involvement in Systemic Lupus Erythematosus. A Controlled Study. Arthritis and Rheumatism. ISSN 0004-3591. 46(5), p. 1228–1232. Show summary

  Objective: To determine if patients with systemic lupus erythematosus (SLE) may have a peripheral neuropathy involving unmyelinated and small, myelinated nerve fibers, by immunostaining epidermal nerve fibers (ENF) in skin biopsy samples for the panaxonal marker, protein gene product 9.5 (PGP 9.5). Methods: Fifteen consecutive and nonselected SLE patients and 15 age- and sex-matched controls were included in the study. The age of the patients ranged from 25 years to 65 years, with a mean +/- SD age of 47.3 +/- 10.2 years and a disease duration of 2-28 years (mean +/- SD 14.8 +/- 8.6 years). Two 3-mm skin biopsy samples were obtained with a punch needle ~10 cm superiour to the lateral malleolus of the right leg and immunostained with 0.1% rabbit polyclonal antibodies to human PGP 9.5. The number of ENF per millimeter was counted and recorded as the mean +/- SD of counts in six 50-um sections, 3 from each of the 2 biopsy samples. Results: The mean number of ENF per mm in patients with SLE was 8.0 +/- 1.5 (range 5.0-9.9), while the matched controls had 12.2 +/- 3.8 ENF per mm (range 6.8-18.6) (P = 0.0006). Conclusion: This study indicates that a small fiber involvement in patients with SLE may be responsible for the prevalent neuropathic symptoms and impaired warm sense that is observed in such patients.

• Omdal, Roald; Mellgren, Svein Ivar; Koldingsnes, Wenche; Jacobsen, E. A. & Husby, Gunnar (2002). Fatigue in patients with systemic lupus erythematosus: lack of association to serum cytokines, antiphospholipid antibodies, or other disease characteristics. Journal of Rheumatology. ISSN 0315-162X. 29(3), p. 482–486.
• Omdal, Roald; Waterloo, Knut; Koldingsnes, Wenche; Husby, Gunnar Andreas & Mellgren, Svein Ivar (2001). Somatic and psychological features of headache in systemic lupus erythematosus. Journal of Rheumatology. ISSN 0315-162X. 28, p. 772–779.
• Gilboe, Inger-Margrethe; Kvien, Tore Kristian & Husby, Gunnar Andreas (2001). Disease course in systemic lupus erythematosus: Changes in health status, disease activity, and organ damage after 2 years. Journal of Rheumatology. ISSN 0315-162X. 28, p. 266–274.
• Endresen, G.K.M. & Husby, Gunnar Andreas (2001). Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 30, p. 129–134.
• Omdal, Roald; Lunde, Per Knut M.; Rasmussen, Knut Einar; Mellgren, Svein Ivar & Husby, Gunnar Andreas (2001). Transesophageal and transthoracic echocardiography and Doppler-examinations in systemic lupus erythematosus. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 30, p. 275–281.
• Gilboe, Inger-Margrethe; Kvien, Tore Kristian; Uhlig, Tillmann & Husby, Gunnar Andreas (2001). Sicca symptoms and secondary Sjøgren's syndrome in systemic lupus erythematosus: comparison to rheumatoid arthritis and correlation to disease variables. Annals of the Rheumatic Diseases. ISSN 0003-4967. 60, p. 1103–1109.
• Waterloo, Knut; Omdal, Roald; Sjøholm, H.; Koldingsnes, Wenche; Jacobsen, E.A. & Sundsfjord, J.A. [Show all 7 contributors for this article] (2001). Neuropsychological function in SLE is not associated with changes in cerebral blood flow. Journal of Neurology. ISSN 0340-5354. 248, p. 595–602.
• Husby, Gunnar Andreas; Brandtzæg, Per; Mellbye, Ove J.; Thompson, Keith & Sletten, Knut (2001). Protein deposition diseases: When structurally altered proteins assemble out of place. Amyloid: Journal of Protein Folding Disorders. ISSN 1350-6129. p. 88–90.
• Waterloo, Knut K; Omdal, Roald; Sjøholm, Hans; Koldingsnes, Wenche; Jacobsen, Eva A & Sundsfjord, Johan A [Show all 8 contributors for this article] (2001). Neuropsychological dysfunction in systemic lupus erythematosus is not associated with changes in cerebral blood flow. Journal of Neurology. ISSN 0340-5354. 248(7), p. 595–602.
• Omdal, Roald; Waterloo, Knut K; Koldingsnes, Wenche; Husby, Gunnar & Mellgren, Svein Ivar (2001). Somatic and psychological features of headache in systemic lupus erythematosus. Journal of Rheumatology. ISSN 0315-162X. 28(4), p. 772–779.
• Omdal, Roald; Lunde, Per; Rasmussen, knut; Mellgren, Svein Ivar & Husby, Gunnar (2001). Transesophageal and transthoracic echocardiography and Doppler-examinations in systemis lupus erythematosus. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 30, p. 275–281. Show summary

  Objective: To search for cardiac abnormalities in systemic lupus erythematosus (SLE). Methods: 35 patients examined by 2-D transthoracal Doppler and transesophageal echocardiography. Results: Mitral and aortic valve abnormalities were seen in 12 patients (34%) respectively, and occured altogether in 16 patients (46%). They were in general significantly asociated with longer disease duration, but not with anticardiolipin antibodies (aCL), disease activity, or any other variable, except for time on corticosteroids, which was significantly longer in patients with aortic valve calcifications. Conclusion: Valve masses and valve thickening - often in combination - are the most frequent structural findings in SLE, occuring more often on the aortic than on the mitral valves. Factors other than antiphospholipid antibodies, medication, hypertension, or coronary heart disease seem to be responsible for this problem. Drugs that modulate inflammation in endo- and pericardial tissue may, at least in part, be resposible for the observed mitral valve calcifications and pericardial fibrosis.

• Omdal, Roald; Løseth, S.; Torbergsen, Torberg; Koldingsnes, Wenche; Husby, Gunnar & Mellgren, Svein Ivar (2001). Peripheral neuropathy in systemic lupus erythematosus - a longitudinal study. Acta Neurologica Scandinavica. ISSN 0001-6314. 103, p. 386–391. Show summary

  Objective: Peripheral neuropathy (PN) is reported to occur in 5-27% of patients with systemic lupus erythematosus (SLE) mostly as a lengthdependent sensorimotor axonopathy. Studies over time have not been performed. Design: Longitudinal study. Subjects and methods: Thirtythree Caucasian SLE patients consented to participate in the study and were subjected to clinical examination, laboratory tests, and nerve conduction velocity (NCV) studies. At the follow-up 7 years later, 7 patients (21%) were dead, 4 refused to participate, and 2 did not want to perform NCV studies. Twenty patients were thus available for longitudinal study. Results: When all SLE patients were considered on a group basis at follow-up, 8 (33%) out of 24 NCV parameters showed significant deterioration despite correction for time, while 16 (67%) were unchanged. Analysis of change from baseline showed that, except for F-responses, several NCV changes were higly dependent (negative regression coefficients) on baseline levels at start of study. No demographic, laboratory, or disease associated quantitative factor was associated with these changes in NCV parameters over time. Nor was a consistent effect on NCV parameters fram any qualitative demographic or disease associated factor confirmed by Repeated Measures ANOVA analyses. Conclusions: A modest progressive neuropathic process exists in patients with SLE. Important is also the finding that, over time, the abnormalities of NCV parameters fluctuate in the individual patients, and the impairments are not necessarily irreversible. This study also shows no association to medication, demographic-, or other disease associated factors.

• Husby, Gunnar Andreas & Marhaug, Gudmund (2000). Protéine amyloide a tissulaire (AA) et sérique (SAA): Biologie moléculaire et role pathogène dans l'amylose AA, Les Amyloses, Flammarion Médicine-Sciences. ISSN 2-257-13288-2. p. 27–48.
• Wien, Tale Norbye; Omtvedt, Lone Aanerud; Landsverk, T. & Husby, Gunnar Andreas (2000). Characterization of Proteoglycans and Glycosaminoglycans in Splenic AA Amyloid Induced in Mink. Scandinavian Journal of Immunology. ISSN 0300-9475. p. 576–583.
• Husby, Gunnar Andreas (2000). Is there a pathogenic link between gamma heavy chain disease and chronic arthritis? Current Opinion in Rheumatology. ISSN 1040-8711. 12, p. 56–70.
• Omtvedt, Lone Aanerud; Bailey, D.; Renouf, David V.; Davies, M.J.; Paramonov, N.A. & Haavik, Svein [Show all 9 contributors for this article] (2000). Glycosylation of immunoglobulin light chains associated with amyloidosis. Amyloid: Journal of Protein Folding Disorders. ISSN 1350-6129. 7, p. 227–244.
• Gilboe, Inger-Margrethe; Kvien, Tore Kristian; Haugeberg, Glenn & Husby, Gunnar Andreas (2000). Bone mineral density in systemic lupus erythematosus: Comparison with rheumatoid arthritis and healthy controls. Annals of the Rheumatic Diseases. ISSN 0003-4967. 59, p. 110–115.
• Danevad, Margerete; Sletten, Knut; Gaarder, P. I.; Mellbye, Ove J. & Husby, Gunnar Andreas (2000). The amino acid sequence of a monoclonal gamma3-heavy chain from a patient with articular gamma-heavy chain deposition disease. Scandinavian Journal of Immunology. ISSN 0300-9475. 51, p. 602–606.
• Husby, Gunnar Andreas (1999). Amyloidose. In Lorenzen, IB; Bendixen, Gunnar & Hansen, Niels Ebbe (Ed.), Medicinsk Kompendium. Nyt Nordisk forlag Arnold Busck. ISSN 87-17-06800-2. p. 606–615.
• Wien, Tale Norbye; Landsverk, T.; Espenes, A.; Gunnes, G.; Nordstoga, Knut & Husby, Gunnar Andreas (1999). Splenic deposition of AA amyloid may be enhanced by Apo A in ellipsoids. In Kyle, RA. & Gertz, MA. (Ed.), Amyloid and Amyloidosis. The Parthenon Publishing Group, New York, London. p. 372–374.
• Husby, Gunnar Andreas; Brandtzæg, Per; Danevad, Margerete; Mellbye, Ove J.; Stenstad, Tore & Sletten, Knut (1999). Chronic arthritis and gamma heavy chain deposition disease: Coincidence or pathogenic link? In Kyle, RA. & Gertz, MA. (Ed.), Amyloid and Amyloidosis. The Parthenon Publishing Group, New York, London. p. 574–576.
• Waterloo, Knut; Omdal, Roald; Jacobsen, E.A.; Kløw, Nils-Einar; Husby, Gunnar Andreas & Torbergsen, T. [Show all 7 contributors for this article] (1999). Cerebral CT and electroencephalography compared with neuropsychological findings in systemic lupus erythematosus. Journal of Neurology. ISSN 0340-5354. 246, p. 706–711.
• Westermark, Per & Husby, Gunnar Andreas (1999). Nomenclature of amyloid fibril proteins. Amyloid: Journal of Protein Folding Disorders. ISSN 1350-6129. 6, p. 63–66.
• Sipe, J. & Husby, Gunnar Andreas (1999). Revised nomenclature for serum amyloid A (SAA). Amyloid: Journal of Protein Folding Disorders. ISSN 1350-6129. 6, p. 67–70.
• Endresen, Knut & Husby, Gunnar Andreas (1999). Metotreksat og folater ved reumatoid artritt. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 119, p. 534–537.
• Gilboe, Inger-Margrethe & Husby, Gunnar Andreas (1999). Application of the 1982 Revised Criteria for the Classification of Systemic Lupus Erythematosus on a Cohort of 346 Norwegian Patients with Connective Tissue Disease. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 28, p. 81–87.
• Gilboe, Inger-Margrethe; Kvien, Tore Kristian & Husby, Gunnar Andreas (1999). Health Status in Systemic Lupus Erythematosus compared to Rheumatoid Arthritis and Healthy Controls. Journal of Rheumatology. ISSN 0315-162X. 26(8), p. 1694–1700.
• Bekkelund, S.U.; Torbergsen, T.; Husby, Gunnar Andreas & Mellgren, Svein Ivar (1999). Myopathy and neuropathy in RA. A quantitative controlled electromyographic study. Journal of Rheumatology. ISSN 0315-162X. 26, p. 2348–2351.
• Forseth, Karin Øien; Husby, Gunnar Andreas; Gran, Jan Tore & Førre, Øystein Thorleiv (1999). Prognostic factors for the development of FM in women with self-reported musculoskeletal pain. A prospective study. Journal of Rheumatology. ISSN 0315-162X. 26, p. 2458–2467.
• Jensen, Janicke Cecilie L; Bergem, Heming Olsen; Gilboe, Inger-Margrethe; Husby, Gunnar Andreas & Axell, Tonny (1999). Oral and ocular sicca symptoms and findings are prevalent in systemic lupus erythematosus. Journal of Oral Pathology. ISSN 0300-9777. 28, p. 317–322. Show summary

  The aims of this study were to 1) examine the frequency of oral and ocular sicca symptoms in SLE patients 2) compare saliva and tear volume, salivary proteins, and features of the oral microflora and mucosa to a matched healthy control group 3) relate the findings to disease parameters. Median disease duration was 5.5 years (0.5-28), disease activity 5 (2-20), damage score 1 (0-7), and Schirmer I test 7.5 mm (0-30 mm). Seventeen and twelve patients complained of oral and ocular dryness, respectively. Unstimulated whole saliva and proline-rich proteins in submandibular saliva were significantly reduced in SLE. Oral microbial counts were generally higher in the patients and the number of oral mucosal changes was increased. The results show that sicca symptoms, although frequent, were not correlated to secretory rates of saliva or tears, but to oral microbial counts. There was no obvious correlation to patient's age, disease activity or duration.

• Husby, Gunnar Andreas (1999). In my opinion. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 28.
• Waterloo, Knut K; Omdal, Roald; Jacobsen, Eva A; Kløw, NE; Husby, Gunnar & Torbergsen, torberg [Show all 7 contributors for this article] (1999). Cerebral computed tomography and electroencephalography compared with neuropsychological findings in systemic lupus erythematosus. Journal of Neurology. ISSN 0340-5354. 246(8), p. 706–711.
• Bekkelund, Svein Ivar; Torbergsen, Torberg; Husby, Gunnar & Mellgren, Svein Ivar (1999). Myopathy and Neuropathy in Rheumatoid Arthritis. A Quantitative Controlled Electromyographic Study. Journal of Rheumatology. ISSN 0315-162X. 26(11), p. 2348–2351. Show summary

  Objective: To test the hypothesis that patients with rheumatoid arthritis (RA) have clinical or subclinical evidence of peripheral neuropathy or myopathy. Methods: We studied 40 seropositive women with RA, mean age 46.6 years (SD 6.4), and 56 healthy controls, mean age 43.0 years (SD 9.1). Patients had a mean disease duration of 13.0 years (SD 7.8). We performed electromyographic examination of 4 muscles (extensor digitorum communis (EDC), biceps brachii (BB), vastus lateralis (VL), and tibialis anterior (TA)) on the right side in both groups. Quantitative data included percentage of polyphasic potentials, motor unit potential amplitude, area, duration, turns, and number of polyphasic potentials. Results: There were statistically significantly higher proportions of polyphasic potentials in 3 muscles in patients compared with controls. Mean number of phases in EDC was 4.6 (SD 0.4) in the patients and 4.1 (0.5)in controls (p=0.0001). The values for the VL were 4.1 (SD 0.4) in patients compared with 3.6 (0.4) in controls (p=0.0001), and in the TA 4.5 (SD 0.5) versus 4.0 (0.4) (p=0.0001). We also found significantly increased duration of motor unit potentials in the VL and TA of patients. The amplitudes of motor unit action potentials were not significantly different in the 2 groups. Conclusion: The study reveals an increased prevalence of neurogenic but not myogenic changes in patients with RA compared with controls.

• Gran, Jan Tore & Husby, Gunnar Andreas (1998). Ankylosing Spondylitis: Prevalence and Demography. In Klippel, J.A. & Dieppe, P.A. (Ed.), Rheumatology, Section 6. Mosby, London. ISSN 0-7234-2405-5.
• Husby, Gunnar Andreas (1998). Amyloidosis. In Maddison, I.J.; Isenberg, D.A.; Woo, P. & Glass, D.N. (Ed.), Oxford Textbook of Rheumatology. Oxford Medical Publications. ISSN 0-1926-2699-X. p. 1433–1444.
• Husby, Gunnar Andreas; Blichfeldt, Per; Brinch, Lorentz; Brandtzæg, Per; Mellbye, Ove J. & Sletten, Knut [Show all 7 contributors for this article] (1998). Chronic Arthritis and gamma heavy chain disease: Coincidence or pathogenic link? Scandinavian Journal of Rheumatology. ISSN 0300-9742. 27, p. 257–264.
• Follerås, Gunnar; Nilsen, Ragnhild; Cornwell III, G. G.; Husby, Gunnar Andreas & Sletten, Knut (1998). Glycosylated Bence Jones Protein and its Autologous Light Chain Amyloid Protein Containing Potentially Amyloidogenic Residues. Scandinavian Journal of Immunology. ISSN 0300-9475. 47, p. 348–354.
• Husby, Gunnar Andreas (1998). Treatment of Amyloidosis and the Rheumatologist. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 27, p. 161–165.
• Bruun, C. Foyn; Sanchez, J.-C.; Hochstrasser, D.F.; Husby, Gunnar Andreas & Marhaug, Gudmund (1998). A two-dimensional electrophoretic study of serum amyloid A and C-reactive protein in infants and children. Electrophoresis. ISSN 0173-0835. 19, p. 776–781.
• Koldingsnes, Wenche; Gran, Jan Tore; Omdal, Roald & Husby, Gunnar Andreas (1998). Wegener's granulomatosis, long term follow-up of patients treated with pulse cyclophosphamide. British Journal of Rheumatology. ISSN 0263-7103. 37, p. 659–664.
• Gran, Jan Tore & Husby, Gunnar Andreas (1998). Clinical, epidemiologic, and therapeutic aspects of ankylosing spondylitis. Current Opinion in Rheumatology. ISSN 1040-8711. 10, p. 292–298.
• Waterloo, Knut; Omdal, Roald; Husby, Gunnar Andreas & Mellgren, Svein Ivar (1998). Emotional Status in Systemic Lupus Erythematosus. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 27, p. 410–414.
• Husby, Gunnar Andreas; Blichfeldt, Per; Brinch, Lorentz; Brandtzæg, Per; Mellbye, Ove J. & Sletten, Knut [Show all 7 contributors for this article] (1998). Chronic arthritis and y heavy chain disease: Coincidence or pathogenic link? Scandinavian Journal of Rheumatology. ISSN 0300-9742. p. 257–264.
• Husby, Gunnar Andreas; Blichfeldt, Per; Brinch, Lorentz; Brandtzæg, Per; Mellbye, Ove J. & Sletten, Kari [Show all 7 contributors for this article] (1998). Chronic arthritis and _g heavy chain disease: coincidence or pathogenic link? Scandinavian Journal of Rheumatology. ISSN 0300-9742. 27, p. 257–264.
• Foss, S. Grethe; Nilsen, Ragnhild; Cornwell III, G. G.; Husby, Gunnar Andreas & Sletten, Knut (1998). A Glycosylated Bence Jones Protein and its Autologous Amyloid Light Chain Containing Potentially Amyloidogenic Residues. Scandinavian Journal of Immunology. ISSN 0300-9475. 47, p. 348–355.
• Husby, Gunnar Andreas; Blichfeldt, Per; Brinch, Lorentz; Brandtzæg, Per; Mellbye, J. Ove & Sletten, Knut [Show all 7 contributors for this article] (1998). Chronic Arthritis and Gamma Heavy Chain Disease: Coincidence or Pathogenic Link? Scandinavian Journal of Rheumatology. ISSN 0300-9742. 27, p. 257–265.
• Waterloo, Knut K; Omdal, Roald; Husby, Gunnar & Mellgren, Svein Ivar (1998). Emotional status in systemic lupus erythematosus. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 27(6), p. 410–414.
• Gran, Jan Tore & Husby, Gunnar Andreas (1997). Seronegative polyarthritis. In Koopman, WJ. (Eds.), Arthritis and Allied Conditions. Williams & Wilkins. ISSN 0-683-04728-0. p. 1145–1153.
• Pierre-Jerome, C.; Bekkelund, S I.; Mellgren, Svein Ivar; Torbergsen, T.; Husby, Gunnar Andreas & Nordstrøm, R. (1997). The Rheumatoid Wrist: Bilateral MR analysis of the Distribution of Rheumatoid Lesions in Axial Plan in a Female Population. Clinical Rheumatology. ISSN 0770-3198. 16, p. 80–86.
• Omtvedt, Lone Aanerud; Husby, Gunnar Andreas; Cornwell III, G. G.; Kyle, RA. & Sletten, Knut (1997). The Amino Acid Sequence of the Glycosylated Amyloid Immunoglobulin Light Chain Protein AS MS. Scandinavian Journal of Immunology. ISSN 0300-9475. 45, p. 551–556.
• Waterloo, Knut; Omdal, Roald; Mellgren, Svein Ivar & Husby, Gunnar Andreas (1997). Neuropsychological functions in systemic lupus erythematosus: a comparison with chronic whiplash patients. European Journal of Neurology. ISSN 1351-5101. 4, p. 171–177.
• Waterloo, Knut K; Omdal, Roald; Mellgren, Svein Ivar & Husby, Gunnar (1997). Neuropsychological functions in systemic lupus erythematosus: a comparison with chronic whiplash patients. European Journal of Neurology. ISSN 1351-5101. 4, p. 171–177.
• Pierre-Jerome, C.; Bekkelund, Svein Ivar; Mellgren, Svein Ivar; Torbergsen, Torberg; Husby, Gunnar & Nordstrøm, R. (1997). The Rheumatoid Wrist: Bilateral MR analysis of the Distribution of Rheumatoid Lesions in Axial Plan in a Female Population. Clinical Rheumatology. ISSN 0770-3198. 16(1), p. 80–86. Show summary

  In this case-control study, we analyzed 146 wrists: a) to search for the distribution pattern of the rheumatoid lesions and, b) to correlate the distribution pattern of these lesions with the clinical parameters. Thirty-one patients with rheumatoid arthritis (RA) and 42 controls - all women - were examined by means of a bilateral MR fast field echo (FFE) sequence, in axial plan. The wrist was divided into three regions: metacarpal (level I), carpal (level II) and radioulnar (level III). Erosions were present in thirty (97%) patients and in six (14%) controls. They were asymmetrically distributed at all levels, mainly at level II. Marrow infiltration and bone destruction were seen in 35% of the patients in an asymmetrical pattern at level I and II, respectively. These lesions were absent in the control group. Subchondral cysts were asymmetrically present in both groups - in 48% of the patients at levels II and III, and in 11% of the controls at level II. In the patient group, this asymmetrical pattern of the lesions correlated with the disease duration at levels I and II (p=0.011 and p=0.013, respectively). Most lesions were found at the radial force-bearing column of the wrist, more in the right side. Synovial hypertrophy and hyperintense median nerve were evident in 96% and 70% of the patients, respectively. We concluded that contrary to common belief rheumatoid damages to the carpal bones become rather asymmetrical as the disease progresses. The line of force along the radial side of the wrist possibly influences the distribution pattern of the rheumatoid lesions.

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• Omtvedt, Lone Aanerud; Royle, L; Husby, Gunnar Andreas; Sletten, Knut; Radcliffe, C & Dwek, RA [Show all 8 contributors for this article] (2004). Artefacts formed by addition of urea to N-linked glycans released with peptide-N-glycosidase F for analysis by mass spectrometry. Rapid Communications in Mass Spectrometry. ISSN 0951-4198. 18, p. 2357–2359. doi: 10.1002/rcm.1632.
• Omdal, Roald; Waterloo, Knut K; Koldingsnes, Wenche; Husby, Gunnar; Mellgren, Svein Ivar & Straume, Bjørn (2004). Fatigue and psychological states and traits in systemic lupus erythematosus: Association or causation? Dr. Omdal, et al reply. Journal of Rheumatology. ISSN 0315-162X. 31, p. 823–824.
• Omtvedt, Lone Aanerud; Wien, Tale Norbye; Myran, Theresa; Sletten, Knut & Husby, Gunnar Andreas (2004). Serum amyloid P component in mink.
• Omtvedt, Lone Aanerud; Royle, L; Husby, Gunnar Andreas; Sletten, Knut; Radcliffe, C & Harvey, DJ [Show all 8 contributors for this article] (2004). Glycosylation studies of monoclonal immunoglobulin deposition disorders.
• Omtvedt, Lone Aanerud; Husby, Gunnar Andreas & Sletten, Knut (2003). Glycoproteome Studies of Immunoglobulin Deposition Disorders.
• Elisen, E J.; Bruun, C. Foyn; Nordstoga, Knut; Husby, Gunnar Andreas & Sletten, Knut (2002). SAA and ApoA-1 fragment occurs in a complex in the serum from the domestic blue fox.
• Husby, Gunnar Andreas (2001). Leena Ala-Kokko. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 121.
• Wien, Tale Norbye; Sørby, R.; Omtvedt, Lone Aanerud; Landsverk, T. & Husby, Gunnar Andreas (2001). Kinetics of proteoglycans and glycosaminoglycans in AA amyloidosis.
• Omdal, Roald; Mellgren, Svein Ivar; Goransson, L.; Lindal, S.; Koldingsnes, Wenche & Husby, Gunnar Andreas (2001). Small-fiber neuropathy in SLE: A controlled study.
• Omdal, Roald; Mellgren, Svein Ivar; Koldingsnes, Wenche; Jacobsen, E.A. & Husby, Gunnar Andreas (2001). Fatigue in patients with systemic lupus erythematosus: Lack of associations to serum cytokines, antiphospholipid antibodies, or other disease characteristics.
• Husby, Gunnar Andreas; Aarset, Harald; Brandtzæg, Per; Mellbye, Ove J.; Thompson, Keith & Sletten, Knut (2001). Articular monoclonal immunoglobulin deposition disease (MIDD): Three illustrative cases.
• Husby, Gunnar Andreas; Brandtzæg, Per; Mellbye, Ove J.; Thompson, Keith & Sletten, Knut (2001). Protein deposition diseases: When structurally altered proteins assemble out of place.
• Husby, Gunnar Andreas; Brandtzæg, Per; Mellbye, Ove J.; Thompson, Keith & Sletten, Knut (2001). Articular monoclonal immunoglobulin deposition disease (MIDD): Three ilustrative cases.
• Wien, Tale Norbye; Sørby, R.; Espenes, A.; Gunnes, G.; Landsverk, T. & Husby, Gunnar Andreas (2001). Splenic deposition of AA amyloid may be enhanced by ApoA in ellipsoids.
• Gilboe, Inger-Margrethe; Kvien, Tore Kristian & Husby, Gunnar Andreas (2000). Disease course in systemic lupus erythematosus: Predictors of health status and increased organ damage after 2 years.
• Husby, Gunnar Andreas; Brandtzæg, Per; Danevad, Margerete; Mellbye, J. Ove; Stenstad, Tore & Sletten, Knut (1998). Chronic arthritis and gamma heavy chain disease: Coincidence or pathogenic link?
• Jensen, Janicke Cecilie L; Bergem, Heming Olsen; Gilboe, Inger-Margrethe; Husby, Gunnar Andreas & Axell, Tonny (1998). SLE: sicca symptoms and findings as related to disease activity. Show summary

  Ocular and oral dryness are frequently described in SLE, and about 8-31% of SLE-patients reportedly have secondary Sjögren's syndrome. The aim of this study was to evaluate any relationship between ocular and oral sicca symptoms, saliva and tear secretion, and current disease activity. Patients fulfilling ARA classification criteria for SLE underwent a thorough medical examination within one week prior to the oral examination, including MHAQ, SF-36, SLEDAI- and damage scores and demographic data. The oral examination focused on collection of unstimulated and paraffin chewing stimulated whole saliva, citric acid stimulated parotid and submandibular saliva, microbial analyses and analyses of salivary proteins (reported elsewhere). Specific questions on oral and ocular dryness were asked (Arthritis Rheum 1993,36,340-7) and Shirmer I test was performed. The age span of the SLE-patients (n=20) was 18-78 years, other diseases and drugs known to influence salivary gland function were excluded. A healthy age and sex matched control group with no sicca complaints also underwent an oral examination. Results are presented as medians (with ranges), using non-parametric statistics. Median disease duration for SLE-patients was 5.5 years (0.5-28), disease activity 5 (2-20), damage score 1 (0-7), SF-36 physical 75 (20-100) and MHAQ 1 (1-2). Median salivary secretory rates of patients with SLE was lower than for healthy controls, significantly so for unstimulated whole saliva (0.24 versus 0.37 ml/ min). A total of 12 SLE patients complained of ocular dryness and 17 of oral dryness, 12 patients reported dryness from both eyes and mouth. Median Schirmer I test for SLE patients was 7.5 mm (0-30 mm). Disease activity was positively correlated to the use of drugs and fatigue, and negatively correlated to disease duration and patient's age. Sicca symptoms, although frequent, were not correlated to secretory rates of saliva or tears, but to oral microbial counts and to SF-36 physical. Tear production was negatively correlated to disease duration. In conclusion, no obvious relationship was found between sicca symptoms, saliva or tear production, and disease activity. Supported by the Norwegian Research Council (grants 107574/320, 110527/300)

• Danevad, Margerete; Sletten, Knut; Husby, Gunnar Andreas & Brandtzæg, Petter (1998). Gamma heavy chain disease: characterisation of a unique heavy chain.
• Omtvedt, Lone Aanerud; Bailey, D.; Renouf, David V.; Hounsell, Elisabeth F.; Haavik, Svein & Husby, Gunnar Andreas [Show all 7 contributors for this article] (1998). Glycosylation of amyloid light chain and their implications in the fibrillogenesis.
• Danevad, Margerete; Sletten, Knut; Stenstad, Tore & Husby, Gunnar Andreas (1998). Gamma heavy chain disease: characterization of a unique heavy chain.
• Myran, Theresa; Husby, Gunnar Andreas; Kyle, A. Robert & Sletten, Knut (1998). Studies of a glycosylated AL-chain from a patient with primary amyloidosis.
• Koldingsnes, Wenche; Gran, Jan Tore; Omdal, Roald & Husby, Gunnar Andreas (1997). Wegener's granulomatosis, long time follow-up of patients treated with pulse cyclophosphamide.
• Gilboe, Inger-Margrethe; Kvien, Tore Kristian & Husby, Gunnar Andreas (1997). Health impact in systemic lupus erythematosus (SLE) compared to rheumatoid arthritis (RA)and healthy controls.
• Bergem, Heming Olsen; Gilboe, Inger-Margrethe; Axell, Tonny; Husby, Gunnar Andreas; Lyngstadaas, Ståle Petter & Jensen, Janicke Cecilie L (1997). Oral antifungal factors in patients with systemic lupus erythematosus (SLE).
• Husby, Gunnar Andreas (1997). Amyloid and amyloidosis.
• Husby, Gunnar Andreas (1997). Treatment of amyloidosis - State of the art.
• Bekkelund, S I.; Omdal, Roald; Mellgren, Svein Ivar; Pierre-Jerome, C. & Husby, Gunnar Andreas (1997). White matter hyperintense lesions and psychological impairment in rheumatoid arthritis.
• Bergem, Heming Olsen; Gilboe, Inger-Margrethe; Axell, Tonny; Husby, Gunnar Andreas; Lyngstadaas, Ståle Petter & Jensen, Janicke Cecilie L (1997). Oral antifungal factors in patients with systemic lupus erythematosus (SLE).
• Forseth, Karin Øien; Gran, Jan Tore & Husby, Gunnar Andreas (1997). A population study of the incidence of fibromyalgia among females aged 26-55 years.
• Husby, Gunnar Andreas (1997). Pulsbehandling med cyklofosfamid ved alvorlig bindevevssykdom.

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