Håvard Halland Fretheim

• Scheidegger, Moritz; Boubaya, Marouane; Garaiman, Alexandru; Barua, Imon Shoumitra; Becker, Mike & Bjørkekjær, Hilde Jenssen [Show all 15 contributors for this article] (2024). Characteristics and disease course of untreated patients with interstitial lung disease associated with systemic sclerosis in a real-life two-centre cohort. RMD Open. ISSN 2056-5933. 10(1). doi: 10.1136/rmdopen-2023-003658.
• Strahm, Noemi; Didriksen, Henriette; Fretheim, Håvard Halland; Molberg, Øyvind; Midtvedt, Øyvind & Farstad, Inger Nina [Show all 13 contributors for this article] (2023). Effects of faecal microbiota transplantation on the small intestinal mucosa in systemic sclerosis. Rheumatology. ISSN 1462-0324. 62(8), p. 2918–2929. doi: 10.1093/rheumatology/kead014. Full text in Research Archive
• Didriksen, Henriette; Molberg, Øyvind; Mehta, Adi; Jordan, Suzana; Palchevskiy, Vyacheslav & Fretheim, Håvard Halland [Show all 16 contributors for this article] (2022). Target organ expression and biomarker characterization of chemokine CCL21 in systemic sclerosis associated pulmonary arterial hypertension. Frontiers in Immunology. ISSN 1664-3224. 13. doi: 10.3389/fimmu.2022.991743. Full text in Research Archive
• van Leeuwen, Nina M.; Boonstra, Maaike; Fretheim, Håvard Halland; Brunborg, Cathrine; Midtvedt, Øyvind & Garen, Torhild Oddveig [Show all 10 contributors for this article] (2022). Gastrointestinal symptom severity and progression in systemic sclerosis. Rheumatology. ISSN 1462-0324. 61(10), p. 4024–4034. doi: 10.1093/rheumatology/keac118. Full text in Research Archive
• Schniering, Janine; Maciukiewicz, Malgorzata; Gabrys, Hubert S.; Brunner, Matthias; Blüthgen, Christian & Meier, Chantal [Show all 17 contributors for this article] (2022). Computed tomography-based radiomics decodes prognostic and molecular differences in interstitial lung disease related to systemic sclerosis. European Respiratory Journal. ISSN 0903-1936. 59(5), p. 1–15. doi: 10.1183/13993003.04503-2020. Full text in Research Archive
• Hilberg, Ole; Hoffmann-Vold, Anna-Maria; Smith, Vanessa; Bouros, Demosthenes; Kilpeläinen, Maritta & Guiot, Julien [Show all 18 contributors for this article] (2022). Epidemiology of interstitial lung diseases and their progressive-fibrosing behaviour in six European countries. European Respiratory Journal Open Research (ERJ Open Research). ISSN 2312-0541. 8:00597-2021, p. 1–16. doi: 10.1183/23120541.00597-2021.
• Tennøe, Anders; Murbræch, Klaus; Didriksen, Henriette; Ueland, Thor; Palchevskiy, Vyacheslav & Weigt, Stephen S. [Show all 14 contributors for this article] (2022). Serum markers of cardiac complications in a systemic sclerosis cohort. Scientific Reports. ISSN 2045-2322. 12(4661 ). doi: 10.1038/s41598-022-08815-8. Full text in Research Archive
• Didriksen, Henriette; Molberg, Øyvind; Fretheim, Håvard Halland; Gude, Einar; Jordan, Suzana & Brunborg, Cathrine [Show all 13 contributors for this article] (2021). Association of Lymphangiogenic Factors With Pulmonary Arterial Hypertension in Systemic Sclerosis. Arthritis & Rheumatology. ISSN 2326-5191. 74(7), p. 1277–1287. doi: 10.1002/art.41665.
• Hoffmann-Vold, Anna-Maria; Fretheim, Håvard Halland; Sarna, Vikas Kumar; Barua, Imon Shoumitra; Carstens Nordgård, Maylen & Distler, Oliver [Show all 16 contributors for this article] (2021). Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: Study protocol for the randomised controlled phase II ReSScue trial. BMJ Open. ISSN 2044-6055. 11(6). doi: 10.1136/bmjopen-2020-048541. Full text in Research Archive
• Lemmers, Jacqueline MJ; Fretheim, Håvard Halland; Knaapen, Hanneke KA; Van Den Hoogen, Frank; van Haren-Willems, Jolanda HGM & Duijnhouwer, Anthony L [Show all 10 contributors for this article] (2020). Selexipag treatment in patients with systemic sclerosis–associated pulmonary arterial hypertension in clinical practice, a case series. Journal of Scleroderma and Related Disorders (JSRD). ISSN 2397-1983. 5(3), p. N7–N11. doi: 10.1177/2397198320916082. Full text in Research Archive
• Fretheim, Håvard Halland; Halse, Anne-Kristine; Seip, Marit; Bitter, Helle; Wallenius, Marianne & Garen, Torhild Oddveig [Show all 11 contributors for this article] (2020). Multidimensional tracking of phenotypes and organ involvement in a complete nationwide systemic sclerosis cohort. Rheumatology. ISSN 1462-0324. 59(10), p. 2920–2929. doi: 10.1093/rheumatology/keaa026. Full text in Research Archive Show summary

  Objective. SSc is a severe, heterogeneous multi-organ disease where population-based estimates on phenotypic spectrum, overall disease burden and societal impact are largely missing. Here the objective was to provide the first-ever complete national-level data on phenotype and major organ afflictions in SSc. Methods. A stepwise strategy was applied to find and characterize every SSc patient resident in Norway from 2000 to 2012. First we identified every case in the country registered with an International Classification of Diseases, Tenth Revision code for SSc (M34). Next we manually reviewed all cases coded as M34 to determine whether they met the 1980 ACR and/or 2013 ACR/EULAR classification criteria for SSc and could be included in the Norwegian SSc cohort (Nor-SSc). Finally, all disease features from SSc onset to study end were reviewed. Results. The Nor-SSc cohort included 815 SSc patients. The mean age at diagnosis was 53 years, with 84% females and 77% limited cutaneous SSc. The estimated incidence increased from 4 per million in 2000 to 13 per million in 2012. We identified high cumulative frequencies of internal organ involvement, coexistence of multiple organ afflictions across disease subsets and autoantibody status and stable frequencies of pulmonary arterial hypertension across haemodynamic definitions, but indications of referral-related differences in pulmonary hypertension detection rates across the study area. Conclusion. This nationwide cohort study provides new, unbiased evidence for a high disease burden in SSc patients of Caucas

• Hoffmann-Vold, Anna-Maria; Fretheim, Håvard Halland; Meier, Chantal & Maurer, Britta (2020). Circulating biomarkers of systemic sclerosis – interstitial lung disease. Journal of Scleroderma and Related Disorders (JSRD). ISSN 2397-1983. 5(25), p. 41–47. doi: 10.1177/2397198319894851.
• Fretheim, Håvard Halland; Chung, Brian K.; Didriksen, Henriette; Bækkevold, Espen Sønderaal; Midtvedt, Øyvind & Brunborg, Cathrine [Show all 18 contributors for this article] (2020). Fecal Microbiota Transplantation in Systemic Sclerosis: A Double-Blind, Placebo-Controlled Randomized Pilot Trial. PLOS ONE. ISSN 1932-6203. 15:e0232739(5), p. 1–14. doi: 10.1371/journal.pone.0232739. Full text in Research Archive
• Tennøe, Anders H; Murbraech, Klaus; Andreassen, Johanna; Fretheim, Håvard Halland; Midtvedt, Øyvind & Garen, Torhild Oddveig [Show all 12 contributors for this article] (2019). Systolic Dysfunction in Systemic Sclerosis: Prevalence and Prognostic Implications. ACR Open Rheumatology. ISSN 2578-5745. 1(4), p. 258–266. doi: 10.1002/acr2.1037. Full text in Research Archive
• Hoffmann-Vold, Anna-Maria; Fretheim, Håvard Halland; Halse, Anne-Kristine; Seip, Marit; Bitter, Helle & Wallenius, Marianne [Show all 13 contributors for this article] (2019). Tracking impact of interstitial lung disease in systemic sclerosis in a complete nationwide cohort. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 200(10), p. 1258–1266. doi: 10.1164/rccm.201903-0486OC. Full text in Research Archive Show summary

  Rationale: Interstitial lung disease (ILD) represents a major challenge in systemic sclerosis (SSc), but there are no precise, population-based data on its overall impact, limiting opportunities for screening and management strategies. Objectives: Evaluate impact of ILD in a unique, nationwide, population-based SSc cohort. Methods: ILD was assessed prospectively in the Norwegian SSc (Nor-SSc) cohort, including all 815 patients with SSc resident in the country from 2000 to 2012. Lung high-resolution computed tomography (HRCT) scans were available for fibrosis quantification at baseline (n = 650, 80%) and follow-up. Pulmonary function tests were assessed at baseline (n = 703, 86%) and follow-up. Vital status and standardized mortality ratios (SMRs) were estimated at study end (2018) in the 630 incident Nor-SSc cases and 15 individually matched control subjects. Cumulative survival rates were computed. Measurements and Main Results: At baseline, 50% of the subjects with SSc (n = 324) had ILD by HRCT and 46% displayed pulmonary function declines consistent with ILD progression. Mortality correlated with extent of lung fibrosis as SMR increased from 2.2 with no fibrosis to 8.0 with greater than 25% fibrosis. SMR was inversely related to baseline FVC% and increased at all FVC levels below 100%. In patients with normal-range baseline FVC (80–100%), the 5- and 10-year survival rates correlated with presence or absence of lung fibrosis, being 83% and 80%, respectively, with no fibrosis and 69% and 56%, respectively, with lung fibrosis (P = 0.03). Conclusions: The mere presence of ILD at baseline appears to affect outcome in SSc, suggesting that all patients with SSc should undergo a baseline pulmonary function test and lung HRCT screening to diagnose ILD early and tailor further management.

• Elhai, Muriel; Hoffmann-Vold, Anna-Maria; Avouac, Jérôme; Pezet, Sonia; Cauvet, Anne & Leblond, Agnés [Show all 11 contributors for this article] (2019). Performance of Candidate Serum Biomarkers for Systemic Sclerosis?Associated Interstitial Lung Disease. Arthritis & Rheumatology. ISSN 2326-5191. 71(6), p. 972–982. doi: 10.1002/art.40815. Full text in Research Archive
• Wu, Wanlong; Jordan, Suzana; Becker, Mike Oliver; Dobrota, Rucsandra; Maurer, Britta & Fretheim, Håvard Halland [Show all 11 contributors for this article] (2018). Prediction of progression of interstitial lung disease in patients with systemic sclerosis: The SPAR model. Annals of the Rheumatic Diseases. ISSN 0003-4967. 77(9), p. 1326–1332. doi: 10.1136/annrheumdis-2018-213201.
• Tennøe, Anders; Murbræch, Klaus; Andreassen, Johanna; Fretheim, Håvard Halland; Garen, Torhild Oddveig & Gude, Einar [Show all 10 contributors for this article] (2018). Left ventricular diastolic dysfunction predicts mortality in patients with systemic sclerosis. Journal of the American College of Cardiology. ISSN 0735-1097. 72(15), p. 1804–1813. doi: 10.1016/j.jacc.2018.07.068. Full text in Research Archive
• Hoffmann-Vold, Anna-Maria; Hesselstrand, Roger; Fretheim, Håvard Halland; Ueland, Thor; Andreassen, Arne K. & Brunborg, Cathrine [Show all 12 contributors for this article] (2018). CCL21 as a Potential Serum Biomarker for Pulmonary Arterial Hypertension in Systemic Sclerosis. Arthritis & Rheumatology. ISSN 2326-5191. 70(10), p. 1644–1653. doi: 10.1002/art.40534.
• Hoffmann-Vold, Anna-Maria; Fretheim, Håvard Halland; Midtvedt, Øyvind; Kilian, Karin Renate; Angelshaug, Marianne & Chaudhary, Asad [Show all 12 contributors for this article] (2018). Frequencies of borderline pulmonary hypertension before and after the DETECT algorithm: Results from a prospective systemic sclerosis cohort. Rheumatology. ISSN 1462-0324. 57(3), p. 480–487. doi: 10.1093/rheumatology/kex435.

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• Hoffmann-Vold, Anna-Maria; Fretheim, Håvard Halland; Didriksen, Henriette & Molberg, Øyvind (2020). The potential of fecal microbiota transplantation in systemic sclerosis. Expert Review of Clinical Immunology. ISSN 1744-666X. VOL. 16,(NO. 2,), p. 117–118. doi: 10.1080/1744666X.2019.1707665. Full text in Research Archive
• Fretheim, Håvard Halland; Seip, Marit; Halse, Anne-Kristine; Bitter, Helle; Wallenius, Marianne & Aaløkken, Trond Mogens [Show all 10 contributors for this article] (2018). Characteristics of mild to to moderate lung disease in systemic sclerosis and impact of survival, data from the population-based, nationwide norwegian cohort. Annals of the Rheumatic Diseases. ISSN 0003-4967. 77, p. A418–A418. doi: 10.1136/annrheumdis-2018-eular.7121.
• Hoffmann-Vold, Anna-Maria; Fretheim, Håvard Halland; Halse, Anne-Kristine; Seip, Marit; Wallenius, Marianne & Bitter, Helle [Show all 9 contributors for this article] (2017). Norway as a national reference population for systemic sclerosis; preliminary results from a complete, nationwide cohort. Arthritis & Rheumatology. ISSN 2326-5191. 69.

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