Helge Rørvik Røsjø

• Solberg, Magnar Gangås; Enger, Steve; Berge, Trygve; Rønningen, Peter Selmer; Aagaard, Erika Nerdrum & Pervez, Mohammad Osman [Show all 12 contributors for this article] (2024). Left atrial function in middle-aged men and women with and without paroxysmal atrial fibrillation: Data from the Akershus Cardiac Examination (ACE) 1950 study. Echocardiography. ISSN 0742-2822. 41(6). doi: 10.1111/echo.15852.
• Young, Juliet; Lyngbakken, Magnus Nakrem; Hveem, Kristian; Røsjø, Helge Rørvik & Omland, Torbjørn (2024). Systolic Blood Pressure, Diastolic Blood Pressure and Pulse Pressure and the Risk of Subclinical Myocardial Injury: The HUNT Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 13(9). doi: 10.1161/JAHA.123.031107.
• Aakre, Kristin Moberg; Lyngbakken, Magnus Nakrem; Faaren, Arne L.; Røsjø, Helge Rørvik; Dalen, Håvard & Omland, Torbjørn (2024). Reference intervals of circulating secretoneurin concentrations determined in a large cohort of community dwellers: the HUNT study. Clinical Chemistry and Laboratory Medicine. ISSN 1434-6621. doi: 10.1515/cclm-2024-0154.
• Mecinaj, Albulena; Gulati, Geeta; Ree, Anne Hansen; Gravdehaug, Berit; Røsjø, Helge Rørvik & Steine, Kjetil [Show all 10 contributors for this article] (2024). Impact of the ESC Cardio-Oncology Guidelines Biomarker Criteria on Incidence of Cancer Therapy–Related Cardiac Dysfunction. JACC: CardioOncology. ISSN 2666-0873. 6(1), p. 83–95. doi: 10.1016/j.jaccao.2023.10.008.
• Bhatnagar, Rahul; Berge, Kristian; Røysland, Ragnhild; Høiseth, Arne Didrik; Brynildsen, Jon & Christensen, Geir [Show all 9 contributors for this article] (2023). Cardiac Troponin T and NT-proBNP for Prediction of 30-Day Readmission or Death in Patients with Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study. Cardiology. ISSN 0008-6312. 148(6), p. 506–516. doi: 10.1159/000533266. Full text in Research Archive
• Ihle-Hansen, Håkon; Vigen, Thea; Berge, Trygve; Walle-Hansen, Marte; Hagberg, Guri & Ihle-Hansen, Hege Beathe [Show all 12 contributors for this article] (2023). Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 12(17), p. 1–10. doi: 10.1161/JAHA.123.030739. Full text in Research Archive
• Sourour, Nur; Riveland, Egil Aarstad; Næsgaard, Patrycja; Kjekshus, Harald; Larsen, Alf Inge & Omland, Torbjørn [Show all 8 contributors for this article] (2023). N-terminal pro-B-type natriuretic peptide for prediction of ventricular arrhythmias: Data from the SMASH study. Clinical Cardiology. ISSN 0160-9289. 46(8), p. 989–996. doi: 10.1002/clc.24074. Full text in Research Archive
• Lyngbakken, Magnus Nakrem; Kimenai, Dorien M.; Hveem, Kristian; Dalen, Håvard; Røsjø, Helge Rørvik & Omland, Torbjørn (2023). Patterns of Cardiac Troponin I Concentrations as Risk Predictors of Cardiovascular Disease and Death: The Trøndelag Health Study. American Journal of Medicine. ISSN 0002-9343. 136(9), p. 902–909.e4. doi: 10.1016/j.amjmed.2023.05.009. Full text in Research Archive
• Røsjø, Helge Rørvik; Meessen, Jennifer; Ottesen, Anett Hellebø; Latini, Roberto & Omland, Torbjørn (2023). Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial. Clinical Biochemistry. ISSN 0009-9120. 118. doi: 10.1016/j.clinbiochem.2023.110595. Full text in Research Archive
• Sæther, Julie Caroline; Vesterbekkmo, Elisabeth Kleivhaug; Taraldsen, Maria Dalen; Gigante, Bruna; Follestad, Turid & Røsjø, Helge Rørvik [Show all 10 contributors for this article] (2023). Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy. Scientific Reports. ISSN 2045-2322. 13(1). doi: 10.1038/s41598-023-34642-6. Full text in Research Archive
• Walle-Hansen, Marte; Berge, Trygve; Vigen, Thea; Myrstad, Marius; Hagberg, Guri & Ihle-Hansen, Hege Beathe [Show all 14 contributors for this article] (2022). Systolic blood pressure at age 40 and cognitive function 25 years later: The Akershus Cardiac Examination (ACE) 1950 Study. Journal of Hypertension. ISSN 0263-6352. 41(1), p. 132–139. doi: 10.1097/HJH.0000000000003312.
• Aagaard, Erika Nerdrum; Lyngbakken, Magnus Nakrem; Kvisvik, Brede Alexander Havneraas; Berge, Trygve; Pervez, Mohammad Osman & Ariansen, Inger Kristine Holtermann [Show all 10 contributors for this article] (2022). Associations between cardiovascular risk factors, biomarkers, and left ventricular mechanical dispersion: insights from the ACE 1950 Study . European Heart Journal Open (EHJ Open). 2(2), p. 1–10. doi: 10.1093/ehjopen/oeac006. Full text in Research Archive
• Lång, Maarit; Jakob, Stephan M.; Takala, Riikka; Lyngbakken, Magnus Nakrem; Turpeinen, Anu & Omland, Torbjørn [Show all 14 contributors for this article] (2022). The prevalence of cardiac complications and their impact on outcomes in patients with non-traumatic subarachnoid hemorrhage. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-24675-8. Full text in Research Archive
• Lyngbakken, Magnus Nakrem; Rønningen, Peter Selmer; Solberg, Magnar Gangås; Berge, Trygve; Brynildsen, Jon & Aagaard, Erika Nerdrum [Show all 11 contributors for this article] (2022). Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes. Heart. ISSN 1355-6037. doi: 10.1136/heartjnl-2022-321608. Full text in Research Archive
• Figtree, Gemma A.; Vernon, Stephen T.; Hadziosmanovic, Nermin; Sundstrom, Johan; Alfredsson, Joakim & Nicholls, Stephen J. [Show all 11 contributors for this article] (2022). Mortality and Cardiovascular Outcomes in Patients Presenting With Non–ST Elevation Myocardial Infarction Despite No Standard Modifiable Risk Factors: Results From the SWEDEHEART Registry. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 11(15). doi: 10.1161/JAHA.121.024818. Full text in Research Archive
• Lyngbakken, Magnus Nakrem; Kvisvik, Brede Alexander Havneraas; Berge, Trygve; Pervez, Mohammad Osman; Aagaard, Erika Nerdrum & Ariansen, Inger Kristine Holtermann [Show all 10 contributors for this article] (2022). Serial blood pressure measurements, left ventricular remodelling and cardiovascular outcomes. European Journal of Clinical Investigation. ISSN 0014-2972. 53(1). doi: 10.1111/eci.13876. Full text in Research Archive Show summary

  Background Hypertension is a risk factor for the development of cardiovascular disease. Whether serial blood pressure (BP) measurements are more closely associated with subclinical left ventricular (LV) remodelling and better predict risk of cardiovascular events over individual BP measurements are not known. Methods We assessed systolic BP, diastolic BP and pulse pressure at several time points during adulthood in 1333 women and 1211 men participating in the Akershus Cardiac Examination 1950 Study. We defined serial BP measurements as the sum of averaged BPs from adjacent consecutive visits indexed to total exposure time between measurements. We assessed the associations between serial and individual BP measurements and (1) LV structure, function and volumes and (2) incident myocardial infarction, ischemic stroke, heart failure and cardiovascular death. Results All indices of higher serial BP measurements were associated with increased indexed LV mass, and the associations were stronger than those of individual BP measurements. Serial diastolic BP pressure was strongly and inversely associated with LV systolic function, while higher serial systolic BP was primarily associated with higher LV volumes. Both serial systolic (incidence rate ratio [IRR] 1.10, 95% CI 1.03 to 1.17) and diastolic BPs (IRR 1.14, 95% CI 1.02 to 1.27) were associated with increased incidence of clinical events. Conclusion In healthy community dwellers without established cardiovascular disease, different serial BP indices associate strongly with LV remodelling and cardiovascular outcomes. Whether the use of serial BP indices for guiding treatment is superior to individual measurements should be explored in additional prospective studies.

• Myhre, Peder Langeland; Claggett, Brian; Yu, Bing; Skali, Hicham; Solomon, Scott D. & Røsjø, Helge Rørvik [Show all 13 contributors for this article] (2022). Sex and Race Differences in N-Terminal Pro-B-type Natriuretic Peptide Concentration and Absolute Risk of Heart Failure in the Community. JAMA cardiology. ISSN 2380-6583. 7(6), p. 623–631. doi: 10.1001/jamacardio.2022.0680.
• Sourour, Nur; Riveland, Egil Aarstad; Rømo, Terje; Næsgaard, Patrycja; Kjekshus, Harald & Larsen, Alf Inge [Show all 9 contributors for this article] (2022). QRS fragmentation is associated with increased risk of ventricular arrhythmias in high-risk patients; Data from the SMASH 1 Study. Annals of Noninvasive Electrocardiology. ISSN 1082-720X. 27(5). doi: 10.1111/anec.12985. Full text in Research Archive
• Rønningen, Peter Selmer; Berge, Trygve; Solberg, Magnar Gangås; Enger, Steve; Pervez, Mohammad Osman & Orstad, Eivind Bjørkan [Show all 13 contributors for this article] (2022). Impact of Blood Pressure in the Early 40s on Left Atrial Volumes in the Mid-60s: Data From the ACE 1950 Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 11(11). doi: 10.1161/JAHA.121.023738. Full text in Research Archive
• Myhre, Peder Langeland; Røsjø, Helge Rørvik; Sarvari, Sebastian; Ukkonen, Heikki; Rademakers, Frank & Engvall, Jan E. [Show all 14 contributors for this article] (2022). Cardiac troponin T and NT-proBNP for detecting myocardial ischemia in suspected chronic coronary syndrome. International Journal of Cardiology. ISSN 0167-5273. 361, p. 14–17. doi: 10.1016/j.ijcard.2022.05.027. Full text in Research Archive
• Caspersen, Nina Faksvåg; Søyseth, Vidar; Lyngbakken, Magnus Nakrem; Berge, Trygve; Ariansen, Inger Kristine Holtermann & Tveit, Arnljot [Show all 8 contributors for this article] (2022). Treatable Traits in Misdiagnosed Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination 1950 Study. COPD: Journal of Chronic Obstructive Pulmonary Disease. ISSN 1541-2555. 9(2), p. 165–180. doi: 10.15326/jcopdf.2021.0265. Full text in Research Archive
• Berge, Kristian; Brynildsen, Jon; Røysland, Ragnhild; Strand, Heidi; Christensen, Geir & Høiseth, Arne Didrik [Show all 9 contributors for this article] (2022). Prognostic value of cardiac biomarkers and National Early Warning Score 2 in acute dyspnoea. Open heart. ISSN 2053-3624. 9(1). doi: 10.1136/openhrt-2021-001938. Full text in Research Archive
• Skranes, Julia Brox; Lyngbakken, Magnus Nakrem; Hveem, Kristian; Røsjø, Helge Rørvik & Omland, Torbjørn (2022). Tobacco Consumption and High-Sensitivity Cardiac Troponin I in the General Population: The HUNT Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 11(2), p. 1–9. doi: 10.1161/JAHA.121.021776. Full text in Research Archive
• Myhre, Peder Langeland; Ottesen, Anett Hellebø; Faaren, Arne L.; Tveit, Sjur Hansen; Springett, Jon & Pyylampi, Johanna [Show all 11 contributors for this article] (2021). Performance of a Novel Research-Use-Only Secretoneurin ELISA in Patients with Suspected Acute Coronary Syndrome: Comparison with an Established Secretoneurin Radioimmunoassay. Cardiology. ISSN 0008-6312. 146(5), p. 566–574. doi: 10.1159/000517444. Full text in Research Archive
• Myhre, Peder Langeland; Lyngbakken, Magnus Nakrem; Berge, Trygve; Røysland, Ragnhild; Aagaard, Erika Nerdrum & Pervez, Mohammad Osman [Show all 13 contributors for this article] (2021). Diagnostic Thresholds for Pre-Diabetes Mellitus and Diabetes Mellitus and Subclinical Cardiac Disease in the General Population: Data From the ACE 1950 Study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 10(11). doi: 10.1161/JAHA.120.020447. Full text in Research Archive
• Axfors, Cathrine; Schmitt, Andreas; Janiaud, Perrine; Hooft, Janneke; Abd-Elsalam, Sherief & Abdo, Ehab [Show all 50 contributors for this article] (2021). Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Nature Communications. ISSN 2041-1723. 12. doi: 10.1038/s41467-021-22446-z. Full text in Research Archive
• Lyngbakken, Magnus Nakrem; Hveem, Kristian; Røsjø, Helge Rørvik & Omland, Torbjørn (2021). Subclinical myocardial injury and risk of COVID-19 in the general population: The Trøndelag Health Study. Clinical Chemistry. ISSN 0009-9147. 68(3), p. 473–475. doi: 10.1093/clinchem/hvab267. Full text in Research Archive
• Myhre, Peder Langeland; Heck, Siri Lagethon; Skranes, Julia Brox; Prebensen, Christian Haugland; Jonassen, Christine M & Berge, Trygve [Show all 15 contributors for this article] (2021). Cardiac pathology 6 months after hospitalization for COVID-19 and association with the acute disease severity. American Heart Journal. ISSN 0002-8703. 242, p. 61–70. doi: 10.1016/j.ahj.2021.08.001. Full text in Research Archive
• Moksnes, Marta Riise; Røsjø, Helge; Richmond, Anne; Lyngbakken, Magnus N; Graham, Sarah E & Hansen, Ailin Falkmo [Show all 30 contributors for this article] (2021). Genome-wide association study of cardiac troponin i in the general population. Human Molecular Genetics. ISSN 0964-6906. 30(21), p. 2027–2039. doi: 10.1093/hmg/ddab124. Full text in Research Archive Show summary

  Circulating cardiac troponin proteins are associated with structural heart disease and predict incident cardiovascular disease in the general population. However, the genetic contribution to cardiac troponin I (cTnI) concentrations and its causal effect on cardiovascular phenotypes are unclear. We combine data from two large population-based studies, the Trøndelag Health Study and the Generation Scotland Scottish Family Health Study, and perform a genome-wide association study of high-sensitivity cTnI concentrations with 48 115 individuals. We further use two-sample Mendelian randomization to investigate the causal effects of circulating cTnI on acute myocardial infarction (AMI) and heart failure (HF). We identified 12 genetic loci (8 novel) associated with cTnI concentrations. Associated protein-altering variants highlighted putative functional genes: CAND2, HABP2, ANO5, APOH, FHOD3, TNFAIP2, KLKB1 and LMAN1. Phenome-wide association tests in 1688 phecodes and 83 continuous traits in UK Biobank showed associations between a genetic risk score for cTnI and cardiac arrhythmias, metabolic and anthropometric measures. Using two-sample Mendelian randomization, we confirmed the non-causal role of cTnI in AMI (5948 cases, 355 246 controls). We found indications for a causal role of cTnI in HF (47 309 cases and 930 014 controls), but this was not supported by secondary analyses using left ventricular mass as outcome (18 257 individuals). Our findings clarify the biology underlying the heritable contribution to circulating cTnI and support cTnI as a non-causal biomarker for AMI in the general population. Using genetically informed methods for causal inference helps inform the role and value of measuring cTnI in the general population.

• Aakre, Kristin Moberg; Ottesen, Anett Hellebø; Strand, Heidi; Faaren, Arne L.; Alaour, Bashir & Torsvik, Janniche [Show all 11 contributors for this article] (2021). Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis. Clinical Biochemistry. ISSN 0009-9120. 98, p. 74–77. doi: 10.1016/j.clinbiochem.2021.09.014. Full text in Research Archive
• Lyngbakken, Magnus Nakrem; De Lemos, James A.; Hveem, Kristian; Røsjø, Helge Rørvik & Omland, Torbjørn (2021). Lifetime obesity trends are associated with subclinical myocardial injury: The Trøndelag health study. Journal of Internal Medicine. ISSN 0954-6820. p. 1–10. doi: 10.1111/joim.13391. Full text in Research Archive
• Heck, Siri Lagethon; Mecinaj, Albulena; Ree, Anne Hansen; Hoffmann, Pavel; Schulz-Menger, Jeanette & Fagerland, Morten [Show all 12 contributors for this article] (2021). Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): Extended follow-up of a 2×2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol. Circulation. ISSN 0009-7322. 143(25), p. 2431–2440. doi: 10.1161/CIRCULATIONAHA.121.054698. Full text in Research Archive
• Sigurdardóttir, Fjóla Dögg; Lyngbakken, Magnus; Hveem, Kristian; Hrubos-Strøm, Harald; Røsjø, Helge & Redline, Susan [Show all 7 contributors for this article] (2021). Insomnia symptoms and subclinical myocardial injury: Data from the Nord-Trøndelag Health (HUNT) study. Journal of Sleep Research. ISSN 0962-1105. 30(5). doi: 10.1111/jsr.13299. Full text in Research Archive
• Rutkovskiy, Arkady; Lyngbakken, Magnus; Dahl, Mai Britt; Bye, Anja; Pedersen, Marit Holmefjord & Wisløff, Ulrik [Show all 10 contributors for this article] (2021). Circulating MicroRNA-210 Concentrations in Patients with Acute Heart Failure: Data from the Akershus Cardiac Examination 2 Study. Clinical Chemistry. ISSN 0009-9147. 67(6), p. 889–898. doi: 10.1093/clinchem/hvab030. Full text in Research Archive Show summary

  Background MicroRNA (miR)-210 expression is induced by acute and chronic hypoxia and provides prognostic information in patients with aortic stenosis and acute coronary syndrome. We hypothesized that circulating miR-210 concentrations could provide diagnostic and prognostic information in patients with acute heart failure (HF). Methods We measured miR-210 concentrations in serum samples on admission from 314 patients hospitalized for acute dyspnea and 9 healthy control subjects. The diagnostic and prognostic properties of miR-210 were tested in patients after adjudication of all diagnoses and with median follow-up of 464 days. Results All patients and control subjects had miR-210 concentrations within the range of detection, and the analytical variation was low as the coefficient of variation of synthetic spike-in RNA was 4%. Circulating miR-210 concentrations were increased in patients with HF compared to healthy control subjects, but miR-210 concentrations did not separate patients with acute HF (n = 143) from patients with non-HF-related dyspnea (n = 171): the area under the curve was 0.50 (95% CI 0.43–0.57). Circulating miR-210 concentrations were associated with mortality (n = 114) after adjustment for clinical risk factors (hazard ratio 1.65 [95% CI 1.03–2.62] per unit miR-210 increase), but this association was attenuated and not significant after adjustment for established cardiac protein biomarkers. Conclusions Circulating miR-210 concentrations are associated with mortality, but do not add to established protein biomarkers for diagnosis or prognosis in patients with acute dyspnea.

• Lyngbakken, Magnus; Vigen, Thea; Ihle-Hansen, Håkon; Brynildsen, Jon; Berge, Trygve & Rønning, Ole M. [Show all 9 contributors for this article] (2021). Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study. Clinical Biochemistry. ISSN 0009-9120. 93, p. 59–65. doi: 10.1016/j.clinbiochem.2021.04.005. Full text in Research Archive
• Lyngbakken, Magnus; Kvisvik, Brede Alexander; Aagaard, Erika Nerdrum; Berge, Trygve; Pervez, Mohammad Osman & Brynildsen, Jon [Show all 10 contributors for this article] (2020). B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healtahy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study. Clinical Chemistry. ISSN 0009-9147. doi: 10.1093/clinchem/hvaa257. Full text in Research Archive
• Lyngbakken, Magnus; Aagaard, Erika Nerdrum; Kvisvik, Brede Alexander; Berge, Trygve; Pervez, Mohammad Osman & Brynildsen, Jon [Show all 10 contributors for this article] (2020). Cardiac troponin I and T are associated with left ventricular function and structure: Data from the Akershus Cardiac Examination 1950 Study. Clinical Chemistry. ISSN 0009-9147. 66(4), p. 567–578. doi: 10.1093/clinchem/hvaa023. Full text in Research Archive
• Berge, Kristian; Lyngbakken, Magnus; Myhre, Peder Langeland; Brynildsen, Jon; Røysland, Ragnhild & Strand, Heidi [Show all 10 contributors for this article] (2020). High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study. Clinical Biochemistry. ISSN 0009-9120. p. 1–7. doi: 10.1016/j.clinbiochem.2020.11.009. Full text in Research Archive
• Røsjø, Helge; Hijazi, Ziad; Omland, Torbjørn; Westerbergh, Johan; Lyngbakken, Magnus & Alexander, J.H. [Show all 12 contributors for this article] (2020). Cardiac troponin is associated with cardiac outcomes in men and women with atrial fibrillation, insights from the ARISTOTLE trial. Journal of Internal Medicine. ISSN 0954-6820. 288(2), p. 248–259. doi: 10.1111/joim.13072. Full text in Research Archive
• Myhre, Peder Langeland; Prebensen, Christian; Strand, Heidi; Røysland, Ragnhild; Jonassen, Christine M. & Rangberg, Anbjørg [Show all 12 contributors for this article] (2020). Growth Differentiation Factor-15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized with COVID-19. Circulation. ISSN 0009-7322. doi: 10.1161/CIRCULATIONAHA.120.050360.
• Lyngbakken, Magnus; Berdal, Jan Erik; Eskesen, Arne N; Kvale, Dag; Olsen, Inge Christoffer & Rueegg, Corina Silvia [Show all 11 contributors for this article] (2020). A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics. Nature Communications. ISSN 2041-1723. 11:5284, p. 1–6. doi: 10.1038/s41467-020-19056-6. Full text in Research Archive
• Aarsetøy, Reidun; Omland, Torbjørn; Røsjø, Helge; Strand, Heidi; Lindner, Thomas Werner & Aarsetøy, Hildegunn [Show all 8 contributors for this article] (2020). N-terminal pro-B-type natriuretic peptide as a prognostic indicator for 30-day mortality following out-of-hospital cardiac arrest: A prospective observational study. BMC Cardiovascular Disorders. ISSN 1471-2261. 20:382, p. 1–10. doi: 10.1186/s12872-020-01630-x. Full text in Research Archive
• Omland, Torbjørn; Prebensen, Christian; Røysland, Ragnhild; Søvik, Signe; Sørensen, Vibecke & Røsjø, Helge [Show all 9 contributors for this article] (2020). Established Cardiovascular Biomarkers Provide Limited Prognostic Information in Unselected Patients Hospitalized with COVID-19. Circulation. ISSN 0009-7322. 19, p. 1878–1880. doi: 10.1161/CIRCULATIONAHA.120.050089.
• Rønningen, Peter Selmer; Berge, Trygve; Solberg, Magnar Gangås; Enger, Steve; Nygård, Ståle & Pervez, Mohammad Osman [Show all 12 contributors for this article] (2020). Sex differences and higher upper normal limits for left atrial end-systolic volume in individuals in their mid-60s: data from the ACE 1950 Study. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 21(5), p. 501–507. doi: 10.1093/ehjci/jeaa004.
• Chandra, Anupam; Røsjø, Helge; Svensson, My Hanna Sofia; Vigen, Thea; Ihle-Hansen, Håkon & Orstad, Eivind Bjørkan [Show all 14 contributors for this article] (2020). Plasma linoleic acid levels and cardiovascular risk factors: results from the Norwegian ACE 1950 Study. European Journal of Clinical Nutrition. ISSN 0954-3007. doi: 10.1038/s41430-020-0641-4. Full text in Research Archive
• Chandra, Anupam; Lyngbakken, Magnus; Eide, Ivar Anders; Røsjø, Helge; Vigen, Thea & Ihle-Hansen, Håkon [Show all 13 contributors for this article] (2020). Plasma trans fatty acid levels, cardiovascular risk factors and lifestyle: Results from the Akershus cardiac examination 1950 study. Nutrients. ISSN 2072-6643. 12(5). doi: 10.3390/nu12051419. Full text in Research Archive
• Gilmour, Brian Christopher; Gudmundsrud, Ruben; Frank, Johannes; Hov, Amund; Hindkjær Lautrup, Sofie & Aman, Yahyah [Show all 18 contributors for this article] (2020). Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing. Mechanisms of Ageing and Development. ISSN 0047-6374. 186, p. 1–6. doi: 10.1016/j.mad.2020.111208. Full text in Research Archive
• Chandra, Anupam; Røsjø, Helge; Eide, Ivar Anders; Vigen, Thea; Ihle-Hansen, Håkon & Orstad, Eivind Bjørkan [Show all 13 contributors for this article] (2019). Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. European Journal of Nutrition. ISSN 1436-6207. doi: 10.1007/s00394-019-02007-3.
• Aagaard, Erika Nerdrum; Kvisvik, Brede Alexander; Pervez, Mohammad Omar; Lyngbakken, Magnus; Berge, Trygve & Enger, Steve [Show all 12 contributors for this article] (2019). Left ventricular mechanical dispersion in a general population: Data from the Akershus Cardiac Examination 1950 study. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 21. doi: 10.1093/ehjci/jez210.
• Kvisvik, Brede Alexander; Aagaard, Erika Nerdrum; Mørkrid, Lars; Røsjø, Helge; Lyngbakken, Magnus & Smedsrud, Marit Kristine [Show all 11 contributors for this article] (2019). Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease. The International Journal of Cardiovascular Imaging. ISSN 1569-5794. 35, p. 1265–1275. doi: 10.1007/s10554-019-01583-z. Full text in Research Archive
• Myhre, Peder Langeland; Lyngbakken, Magnus; Tveit, Sjur Hansen; Røsjø, Helge & Omland, Torbjørn (2019). Cardiac imaging and circulating biomarkers for primary prevention in the era of precision medicine. Expert Review of Precision Medicine and Drug Development. ISSN 2380-8993. 4(5), p. 299–308. doi: 10.1080/23808993.2019.1660162. Full text in Research Archive
• Vigen, Thea; Ihle-Hansen, Håkon; Lyngbakken, Magnus; Berge, Trygve; Thommessen, Bente & Ihle-Hansen, Hege [Show all 11 contributors for this article] (2019). Carotid Atherosclerosis is Associated with Middle Cerebral Artery Pulsatility Index. Journal of Neuroimaging (JON). ISSN 1051-2284. doi: 10.1111/jon.12684. Full text in Research Archive
• Vigen, Thea; Ihle-Hansen, Håkon; Lyngbakken, Magnus; Berge, Trygve; Thommessen, Bente & Ihle-Hansen, Hege [Show all 12 contributors for this article] (2019). Blood pressure at age 40 predicts carotid atherosclerosis two decades later: Data from the Akershus Cardiac Examination 1950 Study. Journal of Hypertension. ISSN 0263-6352. 37(10), p. 1982–1990. doi: 10.1097/HJH.0000000000002131. Full text in Research Archive
• Velle-Forbord, Torbjørn; Eidlaug, Maria; Debik, Julia Barbara; Sæther, Julie Caroline; Follestad, Turid & Nauman, Javaid [Show all 11 contributors for this article] (2019). Circulating microRNAs as predictive biomarkers of myocardial infarction: Evidence from the HUNT study. Atherosclerosis. ISSN 0021-9150. 289, p. 1–7. doi: 10.1016/j.atherosclerosis.2019.07.024. Full text in Research Archive
• Brynildsen, Jon; Myhre, Peder Langeland; Lyngbakken, Magnus; Klæboe, Lars Gunnar; Stridsberg, Mats & Christensen, Geir Arve [Show all 9 contributors for this article] (2019). Circulating secretoneurin concentrations in patients with moderate to severe aortic stenosis. Clinical Biochemistry. ISSN 0009-9120. 71, p. 17–23. doi: 10.1016/j.clinbiochem.2019.06.008. Full text in Research Archive
• Myhre, Peder Langeland; Claggett, Brian; Ballantyne, Christie M; Selvin, Elizabeth; Røsjø, Helge & Omland, Torbjørn [Show all 9 contributors for this article] (2019). Association between Circulating Troponin Concentrations, Left Ventricular Systolic and Diastolic Functions, and Incident Heart Failure in Older Adults. JAMA cardiology. ISSN 2380-6583. 4(10), p. 997–1006. doi: 10.1001/jamacardio.2019.3113.
• Lyngbakken, Magnus; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian & Omland, Torbjørn (2019). Temporal changes in cardiac troponin i are associated with risk of cardiovascular events in the general population: The Nord-Trøndelag health study. Clinical Chemistry. ISSN 0009-9147. 65(7), p. 871–881. doi: 10.1373/clinchem.2018.301069. Full text in Research Archive
• Chandra, Anupam; Røsjø, Helge; Eide, Ivar Anders; Vigen, Thea; Ihle-Hansen, Håkon & Orstad, Eivind Bjørkan [Show all 13 contributors for this article] (2019). Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. European Journal of Nutrition. ISSN 1436-6207. p. 1–11. doi: 10.1007/s00394-019-02007-3. Full text in Research Archive
• Ihle-Hansen, Håkon; Vigen, Thea; Berge, Trygve; Hagberg, Guri; Engedal, Knut & Rønning, Ole M. [Show all 12 contributors for this article] (2019). Carotid Atherosclerosis and Cognitive Function in a General Population Aged 63-65 Years: Data from the Akershus Cardiac Examination (ACE) 1950 Study. Journal of Alzheimer's Disease. ISSN 1387-2877. 70(4), p. 1041–1049. doi: 10.3233/JAD-190327. Full text in Research Archive
• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Eken, Olav Søvik; Sadredini, Mani; Myhre, Peder Langeland & Shen, Xin [Show all 24 contributors for this article] (2019). Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia. Circulation: Arrhythmia and Electrophysiology. ISSN 1941-3149. 12(4). doi: 10.1161/CIRCEP.118.007045. Full text in Research Archive
• Lyngbakken, Magnus; Myhre, Peder Langeland; Røsjø, Helge & Omland, Torbjørn (2019). Novel biomarkers of cardiovascular disease: Applications in clinical practice. Critical reviews in clinical laboratory sciences. ISSN 1040-8363. 56(1), p. 33–60. doi: 10.1080/10408363.2018.1525335.
• Brynildsen, Jon; Petaja, Liisa; Myhre, Peder Langeland; Lyngbakken, Magnus; Nygård, Ståle & Stridsberg, Mats [Show all 11 contributors for this article] (2019). Circulating Secretoneurin Concentrations After Cardiac Surgery: Data From the FINNish Acute Kidney Injury Heart Study. Critical Care Medicine. ISSN 0090-3493. 47(5), p. e412–e419. doi: 10.1097/CCM.0000000000003670.
• Nielsen, MJ; Thorburn, Douglas; Leeming, DJ; Hov, Johannes Espolin Roksund; Nygård, Ståle & Moum, Bjørn [Show all 15 contributors for this article] (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 48, p. 179–189. doi: 10.1111/apt.14806.
• Berge, Trygve; Lyngbakken, Magnus; Ihle-Hansen, Håkon; Brynildsen, Jon; Pervez, Mohammad Osman & Aagaard, Erika Nerdrum [Show all 14 contributors for this article] (2018). Prevalence of atrial fibrillation and cardiovascular risk factors in a 63-65 years old general population cohort: The Akershus Cardiac Examination (ACE) 1950 Study. BMJ Open. ISSN 2044-6055. 8:e021704(7), p. 1–9. doi: 10.1136/bmjopen-2018-021704. Full text in Research Archive
• Pervez, Mohammad Osman; Winther, Jacob Andreas; Brynildsen, Jon; Strand, Heidi; Christensen, Geir Arve & Høiseth, Arne Didrik [Show all 11 contributors for this article] (2018). Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study. Biomarkers. ISSN 1354-750X. p. 1–11. doi: 10.1080/1354750X.2018.1474258.
• Røsjø, Helge; Masson, Serge; Caironi, Pietro; Stridsberg, Mats; Magnoli, Michela & Christensen, Geir Arve [Show all 12 contributors for this article] (2018). Prognostic value of secretoneurin in patients with severe sepsis and septic shock: Data from the albumin Italian outcome sepsis study. Critical Care Medicine. ISSN 0090-3493. 46(5), p. e404–e410. doi: 10.1097/CCM.0000000000003050. Full text in Research Archive
• Berge, Kristian; Lyngbakken, Magnus; Einvik, Gunnar; Winther, Jacob Andreas; Brynildsen, Jon & Røysland, Ragnhild [Show all 11 contributors for this article] (2018). Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study. Clinical Biochemistry. ISSN 0009-9120. 59, p. 62–68. doi: 10.1016/j.clinbiochem.2018.07.006.
• Myhre, Peder Langeland; Omland, Torbjørn; Sarvari, Sebastian; Ukkonen, Heikki; Rademakers, Frank & Engvall, Jan E. [Show all 14 contributors for this article] (2018). Cardiac troponin T concentrations, reversible myocardial ischemia, and indices of left ventricular remodeling in patients with suspected stable angina pectoris: A DOPPLER-CIP substudy. Clinical Chemistry. ISSN 0009-9147. 64(9), p. 1371–1379. doi: 10.1373/clinchem.2018.288894.
• Caspersen, Nina Faksvåg; Røsjø, Helge; Flyvbjerg, Allan; Bjerre, Mette; Randby, Anna & Hrubos-Strøm, Harald [Show all 8 contributors for this article] (2018). The association between circulating adiponectin levels, lung function and adiposity in subjects from the general population; data from the Akershus Sleep Apnea Project. BMC Pulmonary Medicine. ISSN 1471-2466. 18(54). doi: 10.1186/s12890-018-0618-4.
• Ihle-Hansen, Håkon; Vigen, Thea; Ihle-Hansen, Hege; Rønning, Ole M.; Berge, Trygve & Thommessen, Bente [Show all 12 contributors for this article] (2018). Prevalence of carotid plaque in a 63- to 65-Year-Old Norwegian cohort from the general population: The ACE (Akershus Cardiac Examination) 1950 study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 7(10). doi: 10.1161/JAHA.118.008562. Full text in Research Archive
• Sigurdardottir, Fjola Dogg; Lyngbakken, Magnus Nakrem; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian & Røsjø, Helge [Show all 7 contributors for this article] (2018). Relative prognostic value of cardiac troponin I and C-reactive protein in the general population (from the Nord-Trøndelag Health [HUNT] Study). American Journal of Cardiology. ISSN 0002-9149. 121(8), p. 949–955. doi: 10.1016/j.amjcard.2018.01.004. Full text in Research Archive
• Brynildsen, Jon; Petäjä, Liisa; Pettilä, Ville; Nygård, Ståle; Vaara, Suvi T. & Linko, Rita [Show all 13 contributors for this article] (2018). The predictive value of NT-proBNP and hs-TnT for risk of death in cardiac surgical patients. Clinical Biochemistry. ISSN 0009-9120. 53, p. 65–71. doi: 10.1016/j.clinbiochem.2018.01.012.
• Lyngbakken, Magnus Nakrem; Pervez, Mohammad Osman; Brynildsen, Jon; Pedersen, Marit Holmefjord; Sølvernes, Janne & Christensen, Geir Arve [Show all 9 contributors for this article] (2018). Fibroblast growth factor 23 in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study. Clinical Biochemistry. ISSN 0009-9120. 52, p. 41–47. doi: 10.1016/j.clinbiochem.2017.10.015. Full text in Research Archive
• Heck, Siri Lagethon; Gulati, Geeta; HOFFMANN, PAVEL; von Knobelsdorff-Brenkenhoff, Florian; Storås, Tryggve & Ree, Anne Hansen [Show all 12 contributors for this article] (2018). Effect of candesartan and metoprolol on myocardial tissue composition during anthracycline treatment: The PRADA trial. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 19(5), p. 544–552. doi: 10.1093/ehjci/jex159. Full text in Research Archive Show summary

  Aims: Anthracycline treatment may cause myocyte loss and expansion of the myocardial extracellular volume (ECV) fraction by oedema and fibrosis. We tested the hypotheses that adjuvant treatment for early breast cancer with the anthracycline epirubicin is dose dependently associated with increased ECV fraction and total ECV, as well as reduced total myocardial cellular volume, and that these changes could be prevented by concomitant angiotensin or beta-adrenergic blockade. Methods and results: PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA) was a 2 × 2 factorial, placebo-controlled, double-blinded trial of candesartan and metoprolol. Sixty-nine women had valid ECV measurements. ECV fraction, total ECV, and total cellular volume were measured by cardiovascular magnetic resonance before and at the completion of anthracycline therapy. ECV fraction increased from 27.5 ± 2.7% to 28.6 ± 2.9% (P = 0.002). A cumulative doxorubicin equivalent dose of 268 mg/m2 was associated with greater increase in ECV fraction than doses <268 mg/m2 (mean change 3.4% [95% confidence interval (CI) 1.2, 5.5] vs. 0.7% [95% CI 0.0, 1.5], P = 0.006), as well as greater increase in total ECV (1.9 mL [95% CI 0.4, 3.5] vs. 0.1 mL [95% CI -0.6, 0.8], P = 0.04). In patients receiving candesartan, total cellular volume decreased (-3.5 mL [95% CI - 4.7, -2.2], P < 0.001) while in patients not receiving candesartan, it remained unchanged (P = 0.45; between group difference P = 0.003). Conclusions: Anthracycline therapy is associated with dose-dependent increase in ECV fraction and total ECV. Concomitant treatment with candesartan reduces left ventricular total cellular volume.

• Ihle-Hansen, Håkon; Vigen, Thea; Berge, Trygve; Einvik, Gunnar; Aarsland, Dag & Rønning, Ole M. [Show all 10 contributors for this article] (2017). Montreal Cognitive Assessment in a 63- to 65-year-old Norwegian Cohort from the General Population: Data from the Akershus Cardiac Examination 1950 Study. Dementia and Geriatric Cognitive Disorders Extra. ISSN 1664-5464. 7(3), p. 318–327. doi: 10.1159/000480496. Full text in Research Archive
• Berge, Trygve; Brynildsen, Jon; Larssen, Hege Kristin Netmangen; Onarheim, Sophia; Jenssen, Gaute Reier & Ihle-Hansen, Håkon [Show all 11 contributors for this article] (2017). Systematic screening for atrial fibrillation in a 65-year-old population with risk factors for stroke: data from the Akershus Cardiac Examination 1950 study. Europace. ISSN 1099-5129. 20(3), p. f299–f305. doi: 10.1093/europace/eux293. Full text in Research Archive Show summary

  Aims To investigate the yield of screening for atrial fibrillation (AF) in a cohort of 65-year-old individuals from the general population with additional risk factors for stroke. Methods and results We invited participants with additional risk factors for stroke (CHA2DS2-VASc score ≥2 for men or ≥ 3 for women) without previously known AF from a population-based study in Norway to participate in a 2-week screening for AF. Screening was performed by one-lead ‘thumb electrocardiography (ECG)’ recordings of 30 s twice daily or when the participants experienced symptoms. In total, 1742 (47.0%) participants of the Akershus Cardiac Examination (ACE) 1950 study had at least one additional risk factor for stroke. Of these, 123 cases reported a history of AF and 101 (5.8%) cases were ECG validated. Eight [0.5%, 95% confidence interval (CI) 0.2–0.9] new AF cases were diagnosed by 12-lead ECG at baseline, and 10 additional participants were diagnosed with AF before screening commenced. We invited all 1601 participants who met the inclusion criteria for screening, of which 1510 (94.3%) participants were included (44% women and 56% men). The screening revealed AF in 13 (0.9%, 95% CI 0.5–1.5) participants. The total prevalence of ECG-validated AF after screening among the 65-year-olds with risk factors for stroke was 7.6% (95% CI 6.4–8.9), in men 10.0% (95% CI 8.2–12.0), and in women 4.3% (95% CI 3.0–6.1) (P < 0.001). Conclusion In a group of 1510 well-characterized 65-year-olds with risk factors for stroke, 2-week intermittent ECG screening identified undiagnosed AF in 0.9%. The total prevalence of AF was 7.6%

• Kvisvik, Brede Alexander; Mørkrid, Lars; Røsjø, Helge; Småstuen, Milada C; Rowe, Alexander D. & Eek, Christian [Show all 9 contributors for this article] (2017). Troponinas de alta sensibilidad T vs I en Sindrome Coronario Agudo: Prediccion de lesiones coronarias significativas y pronostico a largo plazo. Acta Bioquimica Clinica Latinoamericana. ISSN 0325-2957. 51(3), p. 395–407.
• Gulati, Geeta; Heck, Siri Lagethon; Røsjø, Helge; Ree, Anne Hansen; HOFFMANN, PAVEL & Hagve, Tor-Arne [Show all 11 contributors for this article] (2017). Neurohormonal blockade and circulating cardiovascular biomarkers during anthracycline therapy in breast cancer patients: Results from the PRADA (Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy) study. Journal of the American Heart Association (JAHA). ISSN 2047-9980. 6(11). doi: 10.1161/JAHA.117.006513. Full text in Research Archive
• Myhre, Peder Langeland; Stridsberg, Mats; Linko, Rita; Okkonen, Marjatta; Nygård, Ståle & Christensen, Geir Arve [Show all 9 contributors for this article] (2017). Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study. Biomarkers. ISSN 1354-750X. 22(8), p. 775–781. doi: 10.1080/1354750X.2016.1269200. Full text in Research Archive
• Winther, Jacob Andreas; Brynildsen, Jon; Høiseth, Arne Didrik; Strand, Heidi; Følling, Ivar & Christensen, Geir Arve [Show all 9 contributors for this article] (2017). Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: Data from the ACE 2 study. Respiratory Research. ISSN 1465-9921. 18(184). doi: 10.1186/s12931-017-0665-z. Full text in Research Archive
• Klæboe, Lars Gunnar; Håland, Trine Synnøve Fink; Leren, Ida Skrinde; ter Bekke, Rachel M. A.; Brekke, Pål Haugar & Røsjø, Helge [Show all 11 contributors for this article] (2017). Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography. Journal of the American Society of Echocardiography. ISSN 0894-7317. 30(8), p. 727–735.e1. doi: 10.1016/j.echo.2017.04.009. Full text in Research Archive
• Ottesen, Anett Hellebø; Christensen, Geir Arve; Omland, Torbjørn & Røsjø, Helge (2017). Glycosylated Chromogranin A: Potential Role in the Pathogenesis of Heart Failure. Current Heart Failure Reports. ISSN 1546-9530. 14. doi: 10.1007/s11897-017-0360-x. Full text in Research Archive
• de Vries, Elisabeth M.G.; Färkkilä, Martti; Milkiewicz, Piotr; Hov, Johannes Espolin Roksund; Eksteen, Bertus & Thorburn, Douglas [Show all 21 contributors for this article] (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. Liver international (Print). ISSN 1478-3223. 37(10), p. 1554–1561. doi: 10.1111/liv.13402. Full text in Research Archive
• Pervez, Mohammad Osman; Lyngbakken, Magnus Nakrem; Myhre, Peder Langeland; Brynildsen, Jon; Langsjøen, Eva Camilla & Høiseth, Arne Didrik [Show all 9 contributors for this article] (2017). Mid-regional pro-adrenomedullin in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study. Clinical Biochemistry. ISSN 0009-9120. 50(7-8), p. 394–400. doi: 10.1016/j.clinbiochem.2016.12.010. Full text in Research Archive
• Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund; Nygård, Ståle; Schrumpf, Erik & Melum, Espen [Show all 23 contributors for this article] (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. Journal of Hepatology. ISSN 0168-8278. 66(6), p. 1214–1222. doi: 10.1016/j.jhep.2017.01.019.

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• Axfors, Cathrine; Schmitt, Andreas M.; Janiaud, Perrine; van’t Hooft, Janneke; Abd-Elsalam, Sherief & Abdo, Ehab F. [Show all 94 contributors for this article] (2024). Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials(Nature Communications, (2021), 12, (1), 10.1038/s41467-021-22446-z). Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-45360-6.
• Sæther, Julie Caroline; Follestad, Turid; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost & Gigante, Bruna [Show all 10 contributors for this article] (2023). Circulating lipoprotein subfractions and microRNAs as potential biomarkers for improved risk prediction of myocardial infarction: the HUNT study.
• Sourour, Nur; Riveland, Egil Aarstad; Omland, Torbjørn; Kjekshus, Harald; Larsen, Alf Inge & Røsjø, Helge Rørvik [Show all 7 contributors for this article] (2023). Re: Detailed association between B-type natriuretic peptide levels and ventricular tachyarrhythmia. Clinical Cardiology. ISSN 0160-9289. 46(12), p. 1604–1605. doi: 10.1002/clc.24145. Full text in Research Archive
• Lundin, Knut Erik Aslaksen; Røsjø, Helge Rørvik; Myhren, Hilde; Kvale, Dag & Rosvold, Elin Olaug (2021). Legeutdanning i en pandemitid. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141. doi: 10.4045/tidsskr.21.0581.
• Berge, Kristian; Lyngbakken, Magnus Nakrem; Omland, Torbjørn; Juliebø, Vibeke; Schirmer, Henrik & Røsjø, Helge Rørvik (2021). Ytterligere læringsmomenter fra et kardiologisk perspektiv. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(1). doi: 10.4045/tidsskr.20.1025.
• Myhre, Peder Langeland; Lyngbakken, Magnus Nakrem; Røsjø, Helge Rørvik & Omland, Torbjørn (2020). Removing stable and adding precision to chronic coronary artery disease. International Journal of Cardiology. ISSN 0167-5273. 316, p. 54–56. doi: 10.1016/j.ijcard.2020.04.063.
• Tveit, Sjur Hansen; Myhre, Peder Langeland; Røsjø, Helge Rørvik & Omland, Torbjørn (2020). Reply: The complementary role of cardiac troponin I and cardiac troponin T. Clinical Biochemistry. ISSN 0009-9120. 78. doi: 10.1016/j.clinbiochem.2020.02.011.
• Lyngbakken, Magnus; Berdal, Jan Erik; Eskesen, Arne N; Kvale, Dag; Inge Christoffer, Olsen & Rangberg, Anbjørg [Show all 10 contributors for this article] (2020). Norwegian Coronavirus Disease 2019 (NO COVID-19) Pragmatic Open label Study to assess early use of hydroxychloroquine sulphate in moderately severe hospitalised patients with coronavirus disease 2019: A structured summary of a study protocol for a randomised controlled trial. Trials. ISSN 1745-6215. 21. doi: 10.1186/s13063-020-04420-0.
• Tveit, Sjur Hansen; Myhre, Peder Langeland; Le, Tri Minh; Seljeflot, Ingebjørg; Høiseth, Arne Didrik & Røsjø, Helge [Show all 7 contributors for this article] (2019). Superiority of high sensitivity cardiac troponin T vs. I for long-term prognostic value in patients with chest pain; data from the Akershus cardiac Examination (ACE) 3 study. Clinical Biochemistry. ISSN 0009-9120. doi: 10.1016/j.clinbiochem.2019.12.016.
• Aarsetøy, Reidun; Omland, Torbjørn; Røsjø, Helge; Strand, Heidi; Aarsetøy, Hildegunn & Staines, Harry [Show all 7 contributors for this article] (2019). N-terminal Pro-B-Type Natriuretic Peptide may serve as a prognostic indicator for 30-day mortality following out-of-hospital cardiac arrest, whereas both high-sensitivity cardiac troponin-T and copeptin did not yield prognostic information. Circulation 2019; 140: Suppl 2, Abstract 135 . Show summary

  Abstract Introduction: Sudden cardiac arrest (SCA) may be due to different underlying conditions. Prior heart disease is a major risk factor, and coronary artery disease is the most common underlying cause. Hs-cTnT and copeptin are used for early diagnosis of acute myocardial infarction, and may also serve as prognostic indicators following an acute coronary syndrome. NT-proBNP is a marker of heart failure and may act as a predictor of mortality in SCA patients. These three biomarkers in relation to ventricular fibrillation (VF) and asystole on scene during resuscitation has not, to our knowledge, been evaluated. Hypothesis: We hypothesized that early-on levels of hs-cTnT, copeptin and NT-proBNP may relate to prognosis. Methods: From February 2007 until November 2010 blood samples were collected from patients aged > 18 years with out-of-hospital cardiac arrest of assumed cardiac origin. EDTA-blood was drawn during or immediately after termination of cardiopulmonary resuscitation or at hospital admission. Hs-cTnT, copeptin and NT-proBNP were all measured by standardized methods. Patients were classified according to first recorded heart rhythm. Both univariate and multivariate analyses, adjusted for age and gender, were performed using a Cox Proportional-Hazards model. Results: A total of 115 patients were included, 77 patients with VF and 38 patients with asystole as first recorded heart rhythm. Forty-four patients (38,3%) survived to 30-day follow-up. There was no significant difference in hs-cTnT (p = 0.71) or copeptin (p = 0.43) between non-survivors and survivors. The mean NT-proBNP level was significantly elevated in non-survivors compared to survivors, p = 0.001. The hazard ratio (HR) in the univariate analysis for patients with NT-proBNP in the highest quartile (Q4) compared to the lowest quartile (Q1) was 4.68 (95% CI 2.05-10.68), p = < 0.001, and in the multivariate analysis HR was 2.52 (95% CI 0.97-6.53), p = 0.058. All patients in the asystole group died. Only NT-proBNP differed between the two groups, with significantly higher values in the asystole group, p = < 0.001. Conclusion: Applying hs-cTnT, copeptin and NT-proBNP for assessment of prognosis in SCA patients with either VF or asystole, only NT-proBNP was found to yield prognostic information.

• Røsjø, Helge Rørvik; Caironi, Pietro; Meessen, Jennifer; Latini, Roberto & Omland, Torbjørn (2018). The authors reply. Critical Care Medicine. ISSN 0090-3493. 46(9), p. E959–E961. doi: 10.1097/CCM.0000000000003248.
• Ottesen, Anett Hellebø; Carlson, Cathrine Rein; Laver, Derek R; Myhre, Peder Langeland; Dalhus, Bjørn & Lunde, Per Kristian [Show all 14 contributors for this article] (2017). Secretoneurin is an Endogenous CaMKII Inhibitor That Attenuates Ca2+-Dependent Arrhythmogenesis. Circulation. ISSN 0009-7322. 136.
• Lyngbakken, Magnus Nakrem; Røsjø, Helge; Holmen, Oddgeir Lingaas; Dalen, Håvard; Hveem, Kristian & Omland, Torbjørn (2017). Temporal Changes in Cardiac Troponin I and Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study.
• Myhre, Peder Langeland & Røsjø, Helge (2017). Cardiovascular biomarkers. Universitetet i Oslo. ISSN 9788283770339.
• Ottesen, Anett Hellebø & Røsjø, Helge (2017). Functional aspects of granin proteins in Cardiac disease. Universitetet i Oslo. ISSN 9788283333916.

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