Hilde Berner Hammer

• Gløersen, Marthe; Hermann-Eriksen, Merete; Hove, Åshild; Kjeken, Ingvild; Mathiessen, Alexander & Hammer, Hilde Berner [Show all 7 contributors for this article] (2024). Lessons learned from the PICASSO trial regarding ultrasound examinations of osteoarthritic hand joints performed by occupational therapists. Ultraschall in der Medizin. ISSN 0172-4614. 45(3), p. 335–336. doi: 10.1055/a-2285-8206.
• Mulrooney, Elisabeth; Neogi, Tuhina; Dagfinrud, Hanne; Hammer, Hilde Berner; Steen Pettersen, Pernille & Kvien, Tore Kristian Aaserud [Show all 8 contributors for this article] (2024). Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain. Osteoarthritis and Cartilage. ISSN 1063-4584. doi: 10.1016/j.joca.2024.04.011.
• Sepriano, Alexandre; Ramiro, Sofia; Landewé, Robert; van der Heijde, Désirée; Ohrndorf, Sarah & FitzGerald, Olivier [Show all 23 contributors for this article] (2024). Adding ultrasound to treat-to-target shows no benefit in achieving clinical remission nor in slowing radiographic progression in rheumatoid arthritis: results from a multicenter prospective cohort. Clinical Rheumatology. ISSN 0770-3198. doi: 10.1007/s10067-024-06978-5.
• Mandl, Peter; D'Agostino, Maria Antonietta; Navarro-Compán, Victoria; Geßl, Irina; Sakellariou, Garifallia & Abhishek, Abhishek [Show all 26 contributors for this article] (2024). 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice. Annals of the Rheumatic Diseases. ISSN 0003-4967. doi: 10.1136/ard-2023-224771.
• Uhlig, Till; Karoliussen, Lars Fridtjof; Sexton, Joseph; Kvien, Tore Kristian Aaserud; Haavardsholm, Espen A. & Hammer, Hilde Berner (2023). Lifestyle factors predict gout outcomes: Results from the NOR-Gout longitudinal 2-year treat-to-target study. RMD Open. ISSN 2056-5933. 9(4). doi: 10.1136/rmdopen-2023-003600. Full text in Research Archive
• Uhlig, Till; Karoliussen, Lars Fridtjof; Sexton, Joseph; Provan, Sella Aarrestad; Kvien, Tore Kristian Aaserud & Haavardsholm, Espen A. [Show all 7 contributors for this article] (2023). Course and predictors of work productivity in gout - results from the NOR-Gout longitudinal 2-year treat-to-target study. Rheumatology. ISSN 1462-0324. 62(12), p. 3886–3892. doi: 10.1093/rheumatology/kead124. Full text in Research Archive Show summary

  Objectives In patients with gout there is a lack of longitudinal studies on the course of work productivity. We explored longitudinal changes in and predictors of work productivity over 2 years. Methods Patients in the NOR-Gout observational study with a recent gout flare and serum urate (sUA) >360 µmol/l attended tight-control visits during escalating urate lowering therapy according to a treat-to-target strategy. From the Work Productivity and Activity Impairment (WPAI) questionnaire, scores for work productivity and activity impairment were assessed over 2 years together with the Beliefs about Medicines Questionnaire and a variety of demographic and clinical variables. Results At baseline patients had a mean age of 56.4 years and 95% were males. WPAI scores at baseline were 5.0% work missed (absenteeism), 19.1% work impairment (presenteeism), 21.4% overall work impairment and 32.1% activity impairment. Work productivity and activity impairment improved during the first months, and remained stable at 1 and 2 years. Comorbidities were not cross-sectionally associated with WPAI scores at baseline, but predicted worse work impairment and activity impairment at year 1. The Beliefs about Medicines Questionnaire subscale with concerns about medicines at baseline independently predicted worse overall work impairment and worse activity impairment at year 1. Conclusions In patients with gout who were intensively treated to the sUA target, work productivity and activity impairment were largely unchanged and at 1 year predicted by comorbidities and patient concerns about medication.

• Ramiro, Sofia; Landewé, Robert; Van Der Heijde, Désireé; Sepriano, Alexandre; Fitzgerald, Oliver & Østergaard, Mikkel [Show all 30 contributors for this article] (2023). Stricter treat-To-Target in RA does not result in less radiographic progression: A longitudinal analysis in RA BIODAM. Rheumatology. ISSN 1462-0324. 62(9), p. 2989–2997. doi: 10.1093/rheumatology/kead021.
• Westerlind, Helga; Glintborg, Bente; Hammer, Hilde Berner; Saevarsdottir, Saedis; Krogh, Niels Steen & Hetland, Merete Lund [Show all 10 contributors for this article] (2023). Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritis: a study of harmonised Swedish, Danish and Norwegian cohorts. RMD Open. ISSN 2056-5933. 9(3), p. 1–15. doi: 10.1136/rmdopen-2023-003027. Full text in Research Archive
• Gløersen, Marthe; Steen Pettersen, Pernille; Neogi, Tuhina; Sexton, Joseph; Kvien, Tore Kristian Aaserud & Hammer, Hilde Berner [Show all 7 contributors for this article] (2023). Associations between pain sensitization and measures of physical function in people with hand osteoarthritis: Results from the Nor-Hand study. Osteoarthritis and Cartilage. ISSN 1063-4584. 31(10), p. 1388–1395. doi: 10.1016/j.joca.2023.07.005. Full text in Research Archive
• Sirotti, Silvia; Terslev, Lene; Filippucci, Emilio; Iagnocco, Annamaria; Moller, Ingrid & Naredo, Esperanza [Show all 33 contributors for this article] (2023). Development and validation of an OMERACT ultrasound scoring system for the extent of calcium pyrophosphate crystal deposition at the joint level and patient level. The Lancet Rheumatology. 5(8), p. e474–e482. doi: 10.1016/S2665-9913(23)00136-4.
• Hammer, Hilde Berner; Pedersen, Sigve Lars; Jonsson, Maria Karolina; Mathsson-Alm, Linda; Gehring, Isabel & Sexton, Joseph [Show all 8 contributors for this article] (2023). Calprotectin, a sensitive marker of inflammation, is robustly assessed in plasma from patients with early or established rheumatoid arthritis by use of different laboratory methods. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 83(5), p. 330–335. doi: 10.1080/00365513.2023.2225223. Full text in Research Archive
• Uhlig, Till; Karoliussen, Lars Fridtjof; Sexton, Joseph; Kvien, Tore Kristian Aaserud; Haavardsholm, Espen A. & Taylor, W.J. [Show all 7 contributors for this article] (2023). Beliefs about medicines in gout patients: results from the NOR-Gout 2-year study. Scandinavian Journal of Rheumatology. ISSN 0300-9742. doi: 10.1080/03009742.2023.2213507. Full text in Research Archive
• Mulrooney, Elisabeth; Neogi, Tuhina; Dagfinrud, Hanne; Hammer, Hilde Berner; Steen Pettersen, Pernille & Gløersen, Marthe [Show all 9 contributors for this article] (2023). Comorbidities in people with hand OA and their associations with pain severity and sensitization: Data from the longitudinal Nor-Hand study. Osteoarthritis and Cartilage Open. ISSN 2665-9131. 5(3). doi: 10.1016/j.ocarto.2023.100367. Full text in Research Archive
• Möller Parera, Ingrid; Miguel, Maribel; Blasi, Joan; Piccaso, Riccardo; Hammer, Hilde Berner & Ortiz-Sagrista, Juan [Show all 9 contributors for this article] (2023). Ultrasound assessment of degenerative muscle sarcopenia: The University of Barcelona ultrasound scoring system for sarcopenia. RMD Open. ISSN 2056-5933. 9:e002779, p. 1–9. doi: 10.1136/rmdopen-2022-002779. Full text in Research Archive
• Tiulpin, Aleksei; Saarakkala, Simo; Mathiessen, Alexander; Hammer, Hilde Berner; Furnes, Ove Nord & Nordsletten, Lars [Show all 8 contributors for this article] (2022). Predicting total knee arthroplasty from ultrasonography using machine learning. Osteoarthritis and Cartilage Open. ISSN 2665-9131. 4(4). doi: 10.1016/j.ocarto.2022.100319. Full text in Research Archive
• Mulrooney, Elisabeth; Neogi, Tuhina; Dagfinrud, Hanne; Hammer, Hilde Berner; Pettersen, Pernille Steen & Gaarden, Torfinn Lødøen [Show all 10 contributors for this article] (2022). The associations of psychological symptoms and cognitive patterns with pain and pain sensitization in people with hand osteoarthritis. Osteoarthritis and Cartilage Open. ISSN 2665-9131. 4(2), p. 1–7. doi: 10.1016/j.ocarto.2022.100267. Full text in Research Archive
• Hammer, Hilde Berner & Caporali, Roberto (2022). Controversies in rheumatology: ultrasound for monitoring of RA-do we need it? Rheumatology. ISSN 1462-0324. 61(11), p. 4245–4251. doi: 10.1093/rheumatology/keac228. Show summary

  Clinical joint examination is the cornerstone for evaluation of patients with RA. However, since large discrepancies have been shown even between experienced rheumatologists in evaluation of joint inflammation, and tender joints may have limited value in reflecting inflammation, US has in recent decades been introduced in the clinical assessments of RA patients. US has high accordance with other imaging modalities and enables detection of clinically difficult pathologies and contributes to assessments of joints difficult to evaluate clinically. However, there is no general agreement on the optimal use of US in rheumatology, and the prevalence of machines as well as the level of experience differs greatly between countries. In addition, standardized use of US in treat-to-target follow-up of RA patients was found not to have any added value. Thus, how to use US in monitoring of RA patients is open for debate. The present article will discuss the pros and cons for using US in the clinical setting.

• Delcoigne, Bénédicte; Provan, Sella Aarrestad; Hammer, Hilde Berner; Di Giuseppe, Daniela; Frisell, Thomas & Glintborg, Bente [Show all 13 contributors for this article] (2022). Do patient-reported measures of disease activity in rheumatoid arthritis vary between countries? Results from a Nordic collaboration. Rheumatology. ISSN 1462-0324. 61(11), p. 4286–4296. doi: 10.1093/rheumatology/keac081. Full text in Research Archive
• Uhlig, Till; Karoliussen, Lars Fridtjof; Sexton, Joseph; Kvien, Tore Kristian; Haavardsholm, Espen A. & Perez-Ruiz, F. [Show all 7 contributors for this article] (2022). Fluctuation and change of serum urate levels and flares in gout: results from the NOR-Gout study. Clinical Rheumatology. ISSN 0770-3198. 41, p. 3817–3823. doi: 10.1007/s10067-022-06416-4. Full text in Research Archive
• Podewski, A.F.; Glimm, A.M.; Fischer, I.; Bruyn, G.A.W.; Hanova, P. & Hammer, Hilde Berner [Show all 12 contributors for this article] (2022). The MCP2 and the wrist plus two extensor compartments are the most affected and responsive joints/tendons out of the US7 score in patients with rheumatoid arthritis-an observational study. Arthritis Research & Therapy. ISSN 1478-6354. 24(1), p. 1–13. doi: 10.1186/s13075-022-02874-y. Full text in Research Archive
• Hammer, Hilde Berner; Rollefstad, Silvia Christin Hellerud; Semb, Anne Grete; Jensen, Gro Elisabeth; Karoliussen, Lars Fridtjof & Terslev, L [Show all 9 contributors for this article] (2022). Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study. RMD Open. ISSN 2056-5933. 8(2), p. 1–5. doi: 10.1136/rmdopen-2022-002348. Full text in Research Archive
• Uhlig, Till; Karoliussen, Lars Fridtjof; Sexton, Joseph; Kvien, Tore Kristian; Haavardsholm, Espen A. & Perez-Ruiz, Fernando [Show all 7 contributors for this article] (2022). One- and 2-year flare rates after treat-to-target and tight-control therapy of gout: results from the NOR-Gout study. Arthritis Research & Therapy. ISSN 1478-6354. 24:88, p. 1–11. doi: 10.1186/s13075-022-02772-3. Full text in Research Archive
• Sundlisæter, Nina Beate Paulshus; Sundin, Ulf Gunnar; Aga, Anna-Birgitte; Sexton, Joseph; Hammer, Hilde Berner & Uhlig, Till [Show all 9 contributors for this article] (2022). Inflammation and biologic therapy in patients with rheumatoid arthritis achieving versus not achieving ACR/EULAR Boolean remission in a treat-to-target study. RMD Open. ISSN 2056-5933. 8(1), p. 1–6. doi: 10.1136/rmdopen-2021-002013. Full text in Research Archive Show summary

  Objective To investigate limiting factors of American College of Rheumatology (ACR)/EULAR Boolean remission in rheumatoid arthritis (RA), and compare patients who fulfil the criteria to patients who only partly fulfil the criteria, with respect to imaging inflammation and biologic disease modifying anti-rheumatic drug (DMARD) usage. Methods Patients with DMARD-naïve RA were treated according to current recommendations in the the ARCTIC trial (Aiming for Remission in rheumatoid arthritis: a randomised trial examining the benefit of ultrasound in a Clinical TIght Control regimen). Limiting factors of reaching ACR/EULAR Boolean remission at 2 years were assessed. Imaging inflammation (ultrasound and MRI) in patients in remission was compared with patients failing to fulfil different components of the criteria. The OR of biologic therapy was calculated using logistic regression. Results Of 203 patients, 112 (55%) reached ACR/EULAR Boolean remission; 49 (24%) fulfilled three of four criteria. The main limiting factors were patient global assessment (PGA) (59%) and tender joints (22%). Imaging inflammation was not significantly different for patients in remission and patients not fulfilling the criteria due to elevated PGA and/or tender joints, but higher odds of using biologics (OR 3.63, 95% CI 1.73 to 7.61) were observed. Conclusions PGA and tender joints were the factors most often limiting achievement of ACR/EULAR Boolean remission. The level of imaging inflammation was not elevated in these patients compared with patients in remission, but the odds of using biologic DMARDs were higher. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

• Gløersen, Marthe; Pettersen, Pernille Steen; Neogi, Tuhina; Jafarzadeh, S. Reza; Vistnes, Maria & Thudium, Christian S. [Show all 11 contributors for this article] (2022). Associations of Body Mass Index With Pain and the Mediating Role of Inflammatory Biomarkers in People With Hand Osteoarthritis. Arthritis & Rheumatology. ISSN 2326-5191. 74(5), p. 810–817. doi: 10.1002/art.42056. Full text in Research Archive
• Gløersen, Marthe; Pettersen, Pernille Steen; Neogi, Tuhina; Slatkowsky-Christensen, Barbara; Kvien, Tore Kristian & Magnusson, Karin [Show all 8 contributors for this article] (2022). Associations of pain sensitisation with tender and painful joint counts in people with hand osteoarthritis: results from the Nor-Hand study. RMD Open. ISSN 2056-5933. 8. doi: 10.1136/rmdopen-2021-001774. Full text in Research Archive Show summary

  Objective: To examine associations of pain sensitisation with tender and painful joint counts and presence of widespread pain in people with hand osteoarthritis (OA). Methods: Pressure pain thresholds (PPT) at a painful finger joint and the tibialis anterior muscle, and temporal summation (TS) were measured in 291 persons with hand OA. We examined whether sex-standardised PPT and TS values were associated with assessor-reported tender hand joint count, self-reported painful hand and total body joint counts and presence of widespread pain using linear and logistic regression analyses adjusted for age, sex, body mass index, education and OA severity. Results: People with lower PPTs at the painful finger joint (measure of peripheral and/or central sensitisation) had more tender and painful hand joints than people with higher PPTs. PPT at tibialis anterior (measure of central sensitisation) was associated with painful total body joint count (beta=−0.82, 95% CI −1.28 to –0.35) and presence of widespread pain (OR=0.57, 95% CI 0.43 to 0.77). The associations between TS (measure of central sensitisation) and joint counts in the hands and the total body were statistically non-significant. Conclusion This cross-sectional study suggested that pain sensitisation (ie, lower PPTs) was associated with joint counts and widespread pain in hand OA. This knowledge may be used for improved pain phenotyping of people with hand OA, which may contribute to better pain management through more personalised medicine. Further studies are needed to assess whether a reduction of pain sensitisation leads to a decrease in tender and painful joint counts.

• Gløersen, Marthe; Steen Pettersen, Pernille; Maugesten, Øystein Gunnar; Mulrooney, Elisabeth; Mathiessen, Alexander & Gammelsrud, Heidi [Show all 14 contributors for this article] (2021). Study protocol for the follow-up examination of the Nor-Hand study: A hospital-based observational cohort study exploring pain and biomarkers in people with hand osteoarthritis. Osteoarthritis and Cartilage Open. ISSN 2665-9131. 3(3). doi: 10.1016/j.ocarto.2021.100198.
• Uhlig, Till; Eskild, Tron Hovind; Karoliussen, Lars Fridtjof; Sexton, Joseph; Kvien, Tore Kristian & Haavardsholm, Espen A. [Show all 8 contributors for this article] (2021). Two-year reduction of dual-energy CT urate depositions during a treat-to-target strategy in gout in the NOR-Gout longitudinal study. Rheumatology. ISSN 1462-0324. 61, p. S181–S185. doi: 10.1093/rheumatology/keab533. Full text in Research Archive Show summary

  Objectives: There is a lack of large longitudinal studies of urate deposition measured by dual-energy computed tomography (DECT) during urate lowering therapy (ULT) in people with gout. We explored longitudinal changes in DECT urate depositions during a treat-to-target strategy with ULT in gout. Methods: Patients with a recent gout flare and serum-urate (sUA) >360 µmol/l attended tight-control visits during escalating ULT. The treatment target was sUA <360 µmol/l, and <300 µmol/l if presence of tophi.A DECT scanner (General Electric Discovery CT750 HD) acquired data from bilateral forefeet and ankles at baseline and after one and two years. Images were scored in known order, using the semi-quantitative Bayat method, by one experienced radiologist who was blinded to serum urate and clinical data. Four regions were scored: the first metatarsophalangeal (MTP1) joint, the other joints of the toes, the ankles and midfeet, and all tendons in the feet and ankles. Results: DECT was measured at baseline in 187 of 211 patients. The mean (S.D.) serum urate level (μmol/l) decreased from 501 (80) at baseline to 311 (48) at 12 months, and 322 (67) at 24 months.DECT scores at all locations decreased during both the first and the second year (p< 0.001 for all comparisons vs baseline), both for patients achieving and not achieving the sUA treatment target. Conclusions: In patients with gout, urate depositions in ankles and feet as measured by DECT decreased both in the first and the second year, when patients were treated using a treat-to-target ULT strategy.

• Gehin, Johanna Elin; Syversen, Silje Watterdal; Warren, David; Goll, Guro Løvik; Sexton, Joseph & Bolstad, Nils [Show all 7 contributors for this article] (2021). Serum etanercept concentrations in relation to disease activity and treatment response assessed by ultrasound, biomarkers and clinical disease activity scores: results from a prospective observational study of patients with rheumatoid arthritis. RMD Open. ISSN 2056-5933. 7(3), p. 1–9. doi: 10.1136/rmdopen-2021-001985. Full text in Research Archive Show summary

  Objectives: To identify the therapeutic range for etanercept and to assess the incidence of anti-etanercept antibody formation. Methods: Associations between etanercept serum concentration and disease activity as well as treatment response were examined in a longitudinal observational study of rheumatoid arthritis patients starting etanercept. Disease activity was assessed by ultrasound (grey scale and power Doppler), 28-joint Disease Activity Score (DAS28), Simplified Disease Activity Index, plasma calprotectin and C reactive protein. Etanercept concentration and anti-etanercept antibodies were analysed using automated in-house fluorescence assays. Results: A total of 89 patients were included, whereof 66% were biological disease-modifying antirheumatic drug (DMARD) naïve and 91% used concomitant synthetic DMARD. At 3 months, the median etanercept concentration was 1.8 (IQR 1.1-2.5) mg/L. Longitudinal associations were found between etanercept concentration and disease activity assessed by plasma calprotectin, C reactive protein and DAS28, but not between etanercept concentration and improvement in disease activity by any of the parameters at 3, 6 or 12 months of treatment. Etanercept concentrations were not significantly different among patients who achieved response or remission, compared with non-response or non-remission. Hence, no therapeutic range could be identified. None of the patients developed anti-etanercept antibodies. Conclusion: Despite the use of sensitive and objective markers of inflammation, a therapeutic range could not be identified for etanercept. Hence, this study suggests that proactive therapeutic drug monitoring is unlikely to benefit rheumatoid arthritis patients treated with etanercept, but a potential benefit in certain clinical situations cannot be excluded.

• Dejaco, Christian; Machado, Pedro M.; Carubbi, Francesco; Bosch, Philipp; Terslev, Lene & Tamborrini, Giorgio [Show all 25 contributors for this article] (2021). EULAR points to consider for the use of imaging to guide interventional procedures in patients with rheumatic and musculoskeletal diseases (RMDs). Annals of the Rheumatic Diseases. ISSN 0003-4967. 81(6), p. 760–767. doi: 10.1136/annrheumdis-2021-221261. Show summary

  Objectives: To develop evidence-based Points to Consider (PtC) for the use of imaging modalities to guide interventional procedures in patients with rheumatic and musculoskeletal diseases (RMDs). Methods: European Alliance of Associations for Rheumatology (EULAR) standardised operating procedures were followed. A systematic literature review was conducted to retrieve data on the role of imaging modalities including ultrasound (US), fluoroscopy, MRI, CT and fusion imaging to guide interventional procedures. Based on evidence and expert opinion, the task force (25 participants consisting of physicians, healthcare professionals and patients from 11 countries) developed PtC, with consensus obtained through voting. The final level of agreement was provided anonymously. Results: A total of three overarching principles and six specific PtC were formulated. The task force recommends preference of imaging over palpation to guide targeted interventional procedures at peripheral joints, periarticular musculoskeletal structures, nerves and the spine. While US is the favoured imaging technique for peripheral joints and nerves, the choice of the imaging method for the spine and sacroiliac joints has to be individualised according to the target, procedure, expertise, availability and radiation exposure. All imaging guided interventions should be performed by a trained specialist using appropriate operational procedures, settings and assistance by technical personnel. Conclusion: These are the first EULAR PtC to provide guidance on the role of imaging to guide interventional procedures in patients with RMDs.

• Hammer, Hilde Berner; Agular, Birte & Terslev, Lene (2021). Fatigue Is Not Associated With Objective Assessments of Inflammation During Tocilizumab Treatment of Patients With Rheumatoid Arthritis. ACR Open Rheumatology. ISSN 2578-5745. 4(3), p. 202–208. doi: 10.1002/acr2.11379. Show summary

  Objective: In patients with rheumatoid arthritis (RA), the relation between fatigue and disease activity is not established, and our objective was to explore in post hoc analyses the associations between fatigue and subjective as well as objective assessments of inflammation during follow-up of patients with RA initiating biologic treatment. Methods: In a Nordic multicenter study, patients with RA starting tocilizumab were examined for fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue sum score) as well as patient-reported outcome measures (PROMs) (patient's global disease activity, joint pain, and Health Assessment Questionnaire Disability Index), clinical examinations (examiner's global disease activity, 28 tender/swollen joint counts), laboratory variables (erythrocyte sedimentation rate, C-reactive protein), and ultrasound assessments (semiquantitative scoring [0-3]) of gray scale and Doppler of 36 joints and 4 tendons) at baseline and 4, 12, and 24 weeks. The associations were explored by using nonparametric tests, including the Wilcoxon rank test, the Mann-Whitney U test, Spearman correlations, and a linear regression and linear mixed model. Results: One hundred ten patients were included (83% female, mean [SD] age 55.6 [12.1] years, mean [SD] RA duration 8.7 [9.5] years, 81% anti-cyclic citrullinated peptide positive). Fatigue, PROMs, and clinical, laboratory, and ultrasound variables all decreased significantly during follow-up, already at 4 weeks (P < 0.001). Fatigue was both cross-sectionally and longitudinally associated with PROMs, whereas there were no or low associations with clinical, laboratory, or ultrasound assessments of inflammation. Baseline fatigue was predictive of PROMs at 12 and 24 weeks (P < 0.05 and P < 0.001, respectively) but not of any objective assessments. Conclusion: Fatigue was primarily associated with subjective assessments of disease activity. Thus, the present study supports fatigue to reflect other aspects of RA disease activity than inflammation.

• Felbo, Sara Kamp; Wiell, Charlotte; Østergaard, Mikkel; Poggenborg, René Panduro; Bøyesen, Pernille Helen & Hammer, Hilde Berner [Show all 14 contributors for this article] (2021). Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging? Rheumatology. ISSN 1462-0324. p. 723–733. doi: 10.1093/rheumatology/keab384. Show summary

  Objective: To investigate the association between clinical joint tenderness and intra- and periarticular inflammation as assessed by ultrasound and magnetic resonance imaging (MRI) in patients with active psoriatic arthritis (PsA) and to explore if the associations differ according to patient-reported outcomes (PROs) and structural damage. Methods: Forty-one patients with active PsA and hand involvement had 76/78 joints examined for swelling/tenderness and ultrasound and MRI of 24 and 12 finger joints, respectively. Synovitis, tenosynovitis, periarticular inflammation and erosions were assessed using OMERACT definitions and scoring systems. Correlation between imaging inflammation sum-scores (intra-and periarticular) and tender/swollen joint counts were calculated using Spearman's rho, agreement at joint level was examined using prevalence and bias adjusted kappa (PABAK). Subgroup analyses explored the influence of PROs and radiographic erosive disease on these associations. Results: No significant correlations were found between tender or swollen joint counts and imaging inflammation sum-scores (rho=-0.31-0.38). In patients with higher level of overall pain, disability and lower self-reported mental health, a tendency towards negative correlations were found. At joint level, intra- and periarticular imaging inflammatory lesions had slight agreement with joint tenderness (PABAK=0.02-0.19) and slight to moderate with swelling (PABAK=0.16-0.54). For tender joints, agreement with imaging inflammation was even weaker in patients with either high overall pain scores, high disability scores, and/or non-erosive disease. Conclusion: Joint tenderness had low association with imaging signs of inflammation in PsA patients, particularly in patients with high self-reported pain, disability and low mental health, indicating that tenderness is influenced by other parameters than local inflammation.

• Hammer, Hilde Berner; Hansen, Inger Marie Jensen; Järvinen, Pentti; Leirisalo-Repo, Marjatta; Ziegelasch, Michael & Agular, Birte [Show all 7 contributors for this article] (2021). Rheumatoid arthritis patients with predominantly tender joints rarely achieve clinical remission despite being in ultrasound remission. Rheumatology - Advances in Practice (Rheumap). ISSN 2514-1775. 5(2). doi: 10.1093/rap/rkab030. Full text in Research Archive Show summary

  Objectives: Given that subjective variables might reduce remission by composite DAS (CDAS), the main objectives were to explore whether RA patients with mainly tender vs mainly swollen joints had differences in patient-reported outcome measures (PROMs), clinical or US assessments or in achieving remission defined by CDAS or US. Methods: In a Nordic multicentre study, RA patients initiating tocilizumab were assessed by PROMs, clinical, laboratory and US assessments (36 joints and 4 tendons) at baseline, 4, 12 and 24 weeks. Remission was defined according to clinical disease activity index (CDAI)/Boolean or no Doppler activity present. Tender-swollen joint differences (TSJDs) were calculated. Statistics exploring changes over time/differences between groups included Wilcoxon, Mann-Whitney, Kruskal-Wallis and Spearman tests. Results: One hundred and ten patients were included [mean (s.d.) age 55.6 (12.1) years, RA duration 8.7 (9.5) years]. All PROMs, clinical, laboratory and US scores decreased during follow-up (P < 0.001). During follow-up, tender joint counts were correlated primarily with PROMs [r = 0.24-0.56 (P < 0.05-0.001)] and swollen joint counts with US synovitis scores [r = 0.33-0.72 (P < 0.05-0.001)]. At 24 weeks, patients with TSJD > 0 had higher PROMs and CDAI (P < 0.05-0.001) but lower US synovitis scores (P < 0.05). Remission by CDAI/Boolean was seen in 26-34% and by Doppler 53%, but only 2-3% of patients with TSJD > 0 achieved CDAI/Boolean remission. Conclusion: Patients with more tender than swollen joints scored higher on subjective assessments but had less US synovitis. They seldom achieved CDAS remission despite many being in Doppler remission. If patients with predominantly tender joints do not reach CDAS remission, objective assessments of inflammation should be performed.

• Holten, Karen; Sundlisæter, Nina Beate Paulshus; Lillegraven, Siri; Sexton, Joseph; Nordberg, Lena Kristine Bugge & Moholt, Ellen [Show all 11 contributors for this article] (2021). Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment. Annals of the Rheumatic Diseases. ISSN 0003-4967. doi: 10.1136/annrheumdis-2021-220750. Full text in Research Archive Show summary

  Objectives: Fatigue is a frequent symptom in rheumatoid arthritis (RA) and has high impact on quality of life. We explored associations between disease activity and fatigue in patients with early RA during the initial 24 months of modern treat-to-target therapy and predictors of fatigue after 24 months of follow-up. Methods: Data were obtained from the treat-to-target, tight control Aiming for Remission in Rheumatoid Arthritis: a Randomised Trial Examining the Benefit of Ultrasound in a Clinical Tight Control Regime (ARCTIC) trial. Fatigue was measured on a visual analogue scale (VAS) from 0 to 100 mm and defined as clinically relevant if VAS was ≥20 mm. Baseline predictors of fatigue at 24 months were analysed by multivariable logistic regression. Results: 205 patients with fatigue data at baseline and 24 months were included. Median (25th, 75th percentiles) symptom duration was 5.4 months (2.8, 10.4), fatigue VAS 37.0 mm (13.0, 62.0) and mean Disease Activity Score (DAS) 3.4 (SD 1.1) at baseline. Prevalence of fatigue declined from 69% at baseline to 38% at 24 months. Fewer swollen joints (OR 0.92, 95% CI 0.87 to 0.98, p=0.006), lower power Doppler ultrasound score (OR 0.95, 95% CI 0.90 to 0.99, p=0.027) and higher patient global assessment (PGA) (OR 1.03, 95% CI 1.01 to 1.04, p<0.001) increased the risk of clinically relevant fatigue at 24 months. Not achieving remission at 6 months was associated with a higher risk of reporting fatigue at 24 months. Conclusions: Fatigue in patients with early RA was prevalent at disease onset, with a rapid and sustained reduction during treatment. Low objective disease activity and high PGA at baseline were predictors of clinically relevant fatigue at 24 months.

• Trickey, Jeanette; Sahbudin, Ilfita; Ammitzbøll-Danielsen, Mads; Azzolin, Irene; Borst, Carina & Bortoluzzi, Alessandra [Show all 43 contributors for this article] (2021). Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study. Annals of the Rheumatic Diseases. ISSN 0003-4967. 81, p. 232–236. doi: 10.1136/annrheumdis-2021-219931. Full text in Research Archive Show summary

  Objectives: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. Methods: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort. Results: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups. Conclusions: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.

• Pettersen, Pernille Steen; Neogi, Tuhina; Magnusson, Karin; Mathiessen, Alexander; Hammer, Hilde Berner & Uhlig, Till [Show all 8 contributors for this article] (2021). Associations between joint pathologies and central sensitization in persons with hand osteoarthritis: Results from the Nor-Hand study. Rheumatology. ISSN 1462-0324. 61(6), p. 2316–2324. doi: 10.1093/rheumatology/keab708. Full text in Research Archive Show summary

  Objective: Pain sensitization is associated with pain severity in persons with hand osteoarthritis (OA). What contributes to pain sensitization is unclear. This study explores whether hand OA pathologies and symptom duration are related to central sensitization. Method: Participants with hand OA in the Nor-Hand study underwent bilateral hand radiography and ultrasound examination. Central sensitization was assessed with pressure pain thresholds (PPT) at remote sites (wrist, trapezius and tibialis anterior muscles) and temporal summation (TS). We examined whether hand OA pathologies, independent of each other, including structural severity (Kellgren-Lawrence sum score, presence of erosive hand OA), inflammatory severity (greyscale synovitis and power Doppler activity sum scores) and symptom duration, were related to central sensitization, adjusting for age, sex, body mass index, comorbidities and OA-severity of knee/hip. Results: In 291 participants (88% women, median age 61, IQR 57-66 years) Kellgren-Lawrence, greyscale synovitis and power Doppler activity sum scores were not associated with lower PPTs at remote sites. Persons with erosive hand OA had lower PPTs at the wrist (adjusted beta -0.75, 95%CI -1.32, -0.19) and tibialis anterior (adjusted beta -0.82, 95%CI -1.54, -0.09) and had greater TS (adjusted beta 0.56, 95%CI 0.12, 1.01) compared with persons with non-erosive disease. No associations were found for symptom duration. Conclusions: A person's overall amount of structural or inflammatory hand OA pathologies does not appear to drive central sensitization. Although persons with erosive hand OA showed greater signs of central sensitization, the small differences suggest that central sensitization is mainly explained by other factors than joint pathologies.

• Naredo, Esperanza; Rodriguez-Garcia, Sebastián C.; Terslev, Lene; Martinoli, Carlo; Klauser, Andrea & Hartung, Wolfgang [Show all 41 contributors for this article] (2021). The EFSUMB Guidelines and Recommendations for Musculoskeletal Ultrasound - Part II: Joint Pathologies, Pediatric Applications, and Guided Procedures. Ultraschall in der Medizin. ISSN 0172-4614. 43(3), p. 252–273. doi: 10.1055/a-1640-9183. Full text in Research Archive
• Fodor, Daniela; Rodriguez-Garcia, Sebastián C.; Cantisani, Vito; Hammer, Hilde B.; Hartung, Wolfgang & Klauser, Andrea [Show all 41 contributors for this article] (2021). The EFSUMB guidelines and recommendations for musculoskeletal ultrasound - Part I: Extraarticular pathologies. Ultraschall in der Medizin. ISSN 0172-4614. doi: 10.1055/a-1562-1455. Full text in Research Archive Show summary

  The first part of the guidelines and recommendations for musculoskeletal ultrasound, produced under the auspices of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB), provides information about the use of musculoskeletal ultrasound for assessing extraarticular structures (muscles, tendons, entheses, ligaments, bones, bursae, fasciae, nerves, skin, subcutaneous tissues, and nails) and their pathologies. Clinical applications, practical points, limitations, and artifacts are described and discussed for every structure. After an extensive literature review, the recommendations have been developed according to the Oxford Centre for Evidence-based Medicine and GRADE criteria and the consensus level was established through a Delphi process. The document is intended to guide clinical users in their daily practice.

• Costantino, Félicie; Carmona, Loreto; Boers, Maarten; Backhaus, Marina; Balint, Peter V. & Bruyn, George A. [Show all 23 contributors for this article] (2021). EULAR recommendations for the reporting of ultrasound studies in rheumatic and musculoskeletal diseases (RMDs). Annals of the Rheumatic Diseases. ISSN 0003-4967. 80(7), p. 840–847. doi: 10.1136/annrheumdis-2020-219816.
• Taylor, William J.; Dalbeth, Nicola; Saag, Kenneth; Singh, Jasvinder A.; Rahn, Elizabeth J. & Mudano, Amy S. [Show all 27 contributors for this article] (2021). Flare rate thresholds for patient assessment of disease activity states in Gout. Journal of Rheumatology. ISSN 0315-162X. 48(2), p. 293–298. doi: 10.3899/jrheum.191242.
• Uhlig, Till; Karoliussen, Lars Fridtjof; Sexton, Joseph; Borgen, Tove; Haavardsholm, Espen A. & Kvien, Tore Kristian [Show all 7 contributors for this article] (2021). 12-month results from the real-life observational treat-to-target and tight-control therapy NOR-Gout study: Achievements of the urate target levels and predictors of obtaining this target. RMD Open. ISSN 2056-5933. 7(1). doi: 10.1136/rmdopen-2021-001628. Full text in Research Archive
• Krafft Sande, Nina; Bøyesen, Pernille Helen; Aga, Anna-Birgitte; Hammer, Hilde Berner; Flatø, Berit & Roth, Johannes [Show all 7 contributors for this article] (2021). Development and reliability of a novel ultrasonographic joint-specific scoring system for synovitis with reference atlas for patients with juvenile idiopathic arthritis. RMD Open. ISSN 2056-5933. 7(2). doi: 10.1136/rmdopen-2021-001581. Full text in Research Archive
• Sundin, Ulf Gunnar; Sundlisæter, Nina Beate Paulshus; Aga, Anna-Birgitte; Sexton, Joseph; Nordberg, Lena Kristine Bugge & Hammer, Hilde Berner [Show all 10 contributors for this article] (2021). Value of MRI and ultrasound for prediction of therapeutic response and erosive progression in patients with early rheumatoid arthritis managed by an aggressive treat-To-Target strategy. RMD Open. ISSN 2056-5933. 7:e001525(1), p. 1–11. doi: 10.1136/rmdopen-2020-001525. Full text in Research Archive
• Hammer, Hilde Berner; Hansen, Ib M.J.; Järvinen, Pentti; Leirisalo-Repo, Marjatta T.; Ziegelasch, Michael & Agular, Birte [Show all 7 contributors for this article] (2021). Major reduction of ultrasound-detected synovitis during subcutaneous tocilizumab treatment: results from a multicentre 24 week study of patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 50, p. 262–270. doi: 10.1080/03009742.2020.1845394.
• Ziegelasch, Michael; Eloff, Emma; Hammer, Hilde Berner; Cedergren, Jan; Martinsson, Klara & Reckner, Åsa [Show all 9 contributors for this article] (2021). Bone Erosions Detected by Ultrasound Are Prognostic for Clinical Arthritis Development in Patients With ACPA and Musculoskeletal Pain. Frontiers in medicine. ISSN 2296-858X. 8, p. 1–8. doi: 10.3389/fmed.2021.653994.
• Christiansen, Sara Nysom; Filippou, Georgios; Scirè, Carlo Alberto; Balint, Peter V.; Bruyn, George AW & Dalbeth, Nicola [Show all 24 contributors for this article] (2021). Consensus-based semi-quantitative ultrasound scoring system for gout lesions: Results of an OMERACT Delphi process and web-reliability exercise. Seminars in Arthritis & Rheumatism. ISSN 0049-0172. 51(3), p. 644–649. doi: 10.1016/j.semarthrit.2020.11.011.
• Ramiro, Sofia; Landewé, Robert Bm; Van Der Heijde, Désirée; Sepriano, Alexandre; Fitzgerald, Oliver & Ostergaard, Mikkel [Show all 31 contributors for this article] (2020). Is treat-to-target really working in rheumatoid arthritis? a longitudinal analysis of a cohort of patients treated in daily practice (RA BIODAM). Annals of the Rheumatic Diseases. ISSN 0003-4967. 79(4), p. 453–459. doi: 10.1136/annrheumdis-2019-216819.
• Maugesten, Øystein Gunnar; Mathiessen, Alexander; Hammer, Hilde Berner; Hestetun, Sigrid Valen; Kvien, Tore Kristian & Uhlig, Till [Show all 8 contributors for this article] (2020). Validity and diagnostic performance of fluorescence optical imaging measuring synovitis in hand osteoarthritis: baseline results from the Nor-Hand cohort. Arthritis Research & Therapy. ISSN 1478-6354. 22(1). doi: 10.1186/s13075-020-02185-0. Full text in Research Archive
• Ranganath, Veena K.; Hammer, Hilde Berner & McQueen, Fiona M. (2020). Contemporary imaging of rheumatoid arthritis: Clinical role of ultrasound and MRI. Baillière's Best Practice & Research : Clinical Rheumatology. ISSN 1521-6942. 34(6). doi: 10.1016/j.berh.2020.101593.
• Sundin, Ulf Gunnar; Aga, Anna-Birgitte; Skare, Øivind; Nordberg, Lena Kristine Bugge; Uhlig, Till & Hammer, Hilde Berner [Show all 10 contributors for this article] (2020). Conventional versus ultrasound treat to target: No difference in magnetic resonance imaging inflammation or joint damage over 2 years in early rheumatoid arthritis. Rheumatology. ISSN 1462-0324. 59(9), p. 2550–2555. doi: 10.1093/rheumatology/kez674. Full text in Research Archive
• Provan, Sella Aarrestad; Michelsen, Brigitte; Sexton, Joseph; Uhlig, Till & Hammer, Hilde Berner (2020). Trajectories of fatigue in actively treated patients with established rheumatoid arthritis starting biologic DMARD therapy. RMD Open. ISSN 2056-5933. 6(3). doi: 10.1136/rmdopen-2020-001372.
• Hammer, Hilde Berner; Karoliussen, Lars Fridtjof; Terslev, Lene; Haavardsholm, Espen A; Kvien, Tore Kristian & Uhlig, Till (2020). Ultrasound shows rapid reduction of crystal depositions during a treat-to-target approach in gout patients: 12-month results from the NOR-Gout study. Annals of the Rheumatic Diseases. ISSN 0003-4967. 79(11), p. 1500–1505. doi: 10.1136/annrheumdis-2020-217392.
• Hammer, Hilde Berner; Michelsen, Brigitte; Sexton, Joe; Uhlig, Till & Provan, Sella Aarrestad (2020). Fatigue is cross-sectionally not associated with objective assessments of inflammation, but changes in fatigue are associated with changes of disease activity assessments during biologic treatment of patients with established rheumatoid arthritis. Clinical Rheumatology. ISSN 0770-3198. p. 1–11. doi: 10.1007/s10067-020-05402-y. Full text in Research Archive
• Pettersen, Pernille Steen; Neogi, Tuhina; Magnusson, Karin; Hammer, Hilde Berner; Uhlig, Till & Kvien, Tore Kristian [Show all 7 contributors for this article] (2020). Associations Between Radiographic and Ultrasound‐Detected Features in Hand Osteoarthritis and Local Pressure Pain Thresholds. Arthritis & Rheumatology. ISSN 2326-5191. 72(6), p. 966–971. doi: 10.1002/art.41199. Full text in Research Archive
• Maksymowych, Walter P.; FitzGerald, Oliver; Østergaard, Mikkel; Homik, Joanne; van der Heijde, Désirée & Lambert, Robert G. [Show all 31 contributors for this article] (2019). Outcomes and Findings of the International Rheumatoid Arthritis (RA) BIODAM Cohort for Validation of Soluble Biomarkers in RA. Journal of Rheumatology. ISSN 0315-162X. doi: 10.3899/jrheum.190302.
• Mandl, Peter; Studenic, Paul; Filippucci, Emilio; Bachta, Artur; Backhaus, Marina & Bong, David [Show all 39 contributors for this article] (2019). Development of semiquantitative ultrasound scoring system to assess cartilage in rheumatoid arthritis. Rheumatology. ISSN 1462-0324. 58(10), p. 1802–1811. doi: 10.1093/rheumatology/kez153.
• Fjellstad, Caroline Mehl; Mathiessen, Alexander; Christensen, Barbara Therese Slatkovsky; Kvien, Tore Kristian; Hammer, Hilde Berner & Bos-Haugen, Ida Kristin (2019). Associations Between Ultrasound-Detected Synovitis, Pain and Function in Interphalangeal and Thumb Base Osteoarthritis: Data From the Nor-Hand Study. Arthritis care & research. ISSN 2151-464X. doi: 10.1002/acr.24047.
• Hammer, Hilde Berner; Kvien, Tore Kristian & Terslev, Lene (2019). Intermetatarsal Bursitis Is Frequent in Patients With Established Rheumatoid Arthritis and Is Associated With Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor. RMD Open. ISSN 2056-5933. 5(2). doi: 10.1136/rmdopen-2019-001076.
• Bruyn, George A.; Iagnocco, Annamaria; Naredo, Esperanza; Balint, Peter VG; Gutierrez, Marwin & Hammer, Hilde Berner [Show all 16 contributors for this article] (2019). OmeRACT definitions for ultrasonographic pathologies and elementary lesions of rheumatic disorders 15 years on. Journal of Rheumatology. ISSN 0315-162X. 46(10), p. 1388–1393. doi: 10.3899/jrheum.181095.
• Macía-Villa, Cristina; Falcao, Sandra; Gutierrez, Marwin; Medina, Julio; Hammer, Hilde Berner & De Miguel, Eugenio (2019). Peritenon extensor tendon inflammation in psoriatic arthritis is an enthesitis-related lesion. Journal of Rheumatology. ISSN 0315-162X. 46(10), p. 1295–1298. doi: 10.3899/jrheum.180856.
• Sepriano, Alexandre; Ramiro, Sofia; FitzGerald, Oliver; Østergaard, Mikkel; Homik, Joanne & van der Heijde, Désirée [Show all 30 contributors for this article] (2019). Adherence to Treat-to-Target Management in Rheumatoid Arthritis and Associated Factors: Data from the International RA BIODAM Cohort. Journal of Rheumatology. ISSN 0315-162X. doi: 10.3899/jrheum.190303.
• Provan, Sella Aarrestad; Rollefstad, Silvia Christin Hellerud; Ikdahl, Eirik; Mathiessen, Alexander; Berg, Inger Jorid & Wilkinson, I. B. [Show all 12 contributors for this article] (2019). Biomarkers of cardiovascular risk across phenotypes of osteoarthritis. Biomed Central Rheumatology. ISSN 2520-1026. 3(33). doi: 10.1186/s41927-019-0081-8.
• Terslev, Lene; Christensen, Robin; Aga, Anna-Birgitte; Sexton, Joseph; Haavardsholm, Espen A. & Hammer, Hilde Berner (2019). Assessing synovitis in the hands in patients with rheumatoid arthritis by ultrasound: an agreement study exploring the most inflammatory active side from two Norwegian trials. Arthritis Research & Therapy. ISSN 1478-6354. 21. doi: 10.1186/s13075-019-1930-y.
• Hammer, Hilde Berner; Michelsen, Brigitte; Sexton, Joseph; Haugen, Ida Kristin; Provan, Sella Aarrestad & Haavardsholm, Espen A. [Show all 8 contributors for this article] (2019). Swollen, but not tender joints, are independently associated with ultrasound synovitis: Results from a longitudinal observational study of patients with established rheumatoid arthritis. Annals of the Rheumatic Diseases. ISSN 0003-4967. 78, p. 1179–1185. doi: 10.1136/annrheumdis-2019-215321.
• Sande, Jon Sigurd; Ulvik, Arve; Midttun, Øivind; Ueland, Per Magne; Hammer, Hilde Berner & Valen, Merete [Show all 8 contributors for this article] (2019). Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors. Journal of Nutrition. ISSN 0022-3166. 149(5), p. 770–775. doi: 10.1093/jn/nxz001.
• Pettersen, Pernille Steen; Neogi, Tuhina; Magnusson, Karin; Hammer, Hilde Berner; Uhlig, Till & Kvien, Tore Kristian [Show all 7 contributors for this article] (2019). Peripheral and Central Sensitization of Pain in Individuals With Hand Osteoarthritis and Associations With Self-Reported Pain Severity. Arthritis & Rheumatology. ISSN 2326-5191. 71(7), p. 1070–1077. doi: 10.1002/art.40850. Full text in Research Archive
• Zabotti, Alen; Filippou, Georgios; Canzoni, Marco; Adinolfi, Antonella; Picerno, Valentina & Carrara, Greta [Show all 24 contributors for this article] (2019). OMERACT agreement and reliability study of ultrasonographic elementary lesions in osteoarthritis of the foot. RMD Open. ISSN 2056-5933. 5(1). doi: 10.1136/rmdopen-2018-000795.
• Provan, Sella Aarrestad; Austad, Cathrine; Halsaa, Vera; Hammer, Hilde Berner; Kvien, Tore Kristian & Uhlig, Till (2019). Fibromyalgia in patients with rheumatoid arthritis. A 10-year follow-up study, results from the Oslo Rheumatoid Arthritis Register. Clinical and Experimental Rheumatology. ISSN 0392-856X. 37(Supplement 116), p. S58–S62.
• Bruyn, George A. W.; Siddle, Heidi J.; Hanova, Petra; Costantino, Félicie; Iagnocco, Annamaria & Sedie, Andrea Delle [Show all 21 contributors for this article] (2019). Ultrasound of Subtalar Joint Synovitis in Patients with Rheumatoid Arthritis: Results of an OMERACT Reliability Exercise Using Consensual Definitions. Journal of Rheumatology. ISSN 0315-162X. 46(4), p. 351–359. doi: 10.3899/jrheum.171490.
• Nordberg, Lena Kristine Bugge; Lillegraven, Siri; Aga, Anna-Birgitte; Sexton, Joseph; Olsen, Inge Christoffer & Lie, Elisabeth [Show all 11 contributors for this article] (2018). Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial. RMD Open. ISSN 2056-5933. 4(2), p. 11–17. doi: 10.1136/rmdopen-2018-000752. Full text in Research Archive
• Macía-Villa, Cristina; Falcao, Sandra; Gutierrez, Marwin; Medina, Julio; Hammer, Hilde Berner & De Miguel, Eugenio (2018). What is metacarpophalangeal joint swelling in psoriatic arthritis? Ultrasound findings and reliability assessment. Clinical and Experimental Rheumatology. ISSN 0392-856X. 36(5), p. 896–899.
• Hammer, Hilde Berner; Michelsen, Brigitte; Provan, Sella Aarrestad; Sexton, Joseph; Lampa, Jon & Uhlig, Till [Show all 7 contributors for this article] (2018). Tender joint count may not reflect inflammatory activity in established rheumatoid arthritis patients: results from a longitudinal study. Arthritis care & research. ISSN 2151-464X. doi: 10.1002/acr.23815.
• Pukšić, Silva; Bolton-King, Pernille; Sexton, Joseph; Michelsen, Brigitte; Kvien, Tore Kristian & Hammer, Hilde Berner (2018). DAPSA and ultrasound show different perspectives of psoriatic arthritis disease activity: results from a 12-month longitudinal observational study in patients starting treatment with biological disease-modifying antirheumatic drugs. RMD Open. ISSN 2056-5933. 4(2). doi: 10.1136/rmdopen-2018-000765.
• Sundlisæter, Nina Beate Paulshus; Olsen, Inge Christoffer; Aga, Anna-Birgitte; Hammer, Hilde Berner; Uhlig, Till & Heijde, Desirée van der [Show all 9 contributors for this article] (2018). Predictors of sustained remission in patients with early rheumatoid arthritis treated according to an aggressive treat-to-target protocol. Rheumatology. ISSN 1462-0324. 57(11), p. 2022–2031. doi: 10.1093/rheumatology/key202.
• Terslev, Lene; Østergaard, Mikkel; Sexton, Joseph & Hammer, Hilde Berner (2018). Is synovial hypertrophy without Doppler activity sensitive to change? Post-hoc analysis from a rheumatoid arthritis ultrasound study. Arthritis Research & Therapy. ISSN 1478-6354. 20(224). doi: 10.1186/s13075-018-1709-6.
• Nordberg, Lena Kristine Bugge; Lillegraven, Siri; Aga, Anna-Birgitte; Sexton, Joseph; Lie, Elisabeth & Hammer, Hilde Berner [Show all 11 contributors for this article] (2018). The impact of ultrasound on the use and efficacy of intraarticular glucocorticoid injections in early rheumatoid arthritis: Secondary analyses from a randomized trial examining the benefit of ultrasound in a clinical tight control regimen. Arthritis & Rheumatology. ISSN 2326-5191. 70(8), p. 1192–1199. doi: 10.1002/art.40494.
• Sundlisæter, Nina Beate Paulshus; Aga, Anna-Birgitte; Olsen, Inge Christoffer; Hammer, Hilde Berner; Uhlig, Till & Heijde, Desirée van der [Show all 9 contributors for this article] (2018). Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: Associations to future good radiographic and physical outcomes. Annals of the Rheumatic Diseases. ISSN 0003-4967. 77(10), p. 1421–1425. doi: 10.1136/annrheumdis-2017-212830. Full text in Research Archive
• Michelsen, Brigitte; Uhlig, Till; Sexton, Joseph; Heijde, Desirée van der; Hammer, Hilde Berner & Kristianslund, Eirik [Show all 13 contributors for this article] (2018). Health-related quality of life in patients with psoriatic and rheumatoid arthritis: Data from the prospective multicentre NOR-DMARD study compared with Norwegian general population controls. Annals of the Rheumatic Diseases. ISSN 0003-4967. 77(9), p. 1290–1294. doi: 10.1136/annrheumdis-2018-213286. Full text in Research Archive
• Hammer, Hilde Berner; Uhlig, Till; Kvien, Tore Kristian & Lampa, Jon (2018). Pain catastrophizing is strongly associated with subjective outcomes, but not with inflammatory assessments in rheumatoid arthritis patients. Arthritis care & research. ISSN 2151-464X. 70(5), p. 703–712. doi: 10.1002/acr.23339.
• Hammer, Hilde Berner; Kvien, Tore Kristian & Terslev, Lene (2017). Tenosynovitis in rheumatoid arthritis patients on biologic treatment: involvement and sensitivity to change compared to joint inflammation. Clinical and Experimental Rheumatology. ISSN 0392-856X. 35(6), p. 959–965.
• Mandl, Peter; Bong, David; Balint, Peter V.; Hammer, Hilde Berner; Miguel, Maribel & Naredo, Esperanza [Show all 8 contributors for this article] (2017). Sonographic and Anatomic Description of the Subtalar Joint. Ultrasound in Medicine and Biology. ISSN 0301-5629. 44(1), p. 119–123. doi: 10.1016/j.ultrasmedbio.2017.09.017.
• Nordal, Hilde Haugedal; Fagerhol, Magne Kristoffer; Halse, Anne-Kristine & Hammer, Hilde Berner (2017). Calprotectin (S100A8/A9) should preferably be measured in EDTA-plasma; results from a longitudinal study of patients with rheumatoid arthritis. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 78(1-2), p. 102–108. doi: 10.1080/00365513.2017.1419371.
• Möller, Ingrid; Janta, Iustina; Backhaus, Marina; Ohrndorf, Sarah; Bong, David A. & Martinoli, Carlo [Show all 38 contributors for this article] (2017). The 2017 EULAR standardised procedures for ultrasound imaging in rheumatology. Annals of the Rheumatic Diseases. ISSN 0003-4967. 76(12). doi: 10.1136/annrheumdis-2017-211585.
• Jonsson, Maria Karolina; Sundlisæter, Nina Beate Paulshus; Nordal, Hilde Haugedal; Hammer, Hilde Berner; Aga, Anna-Birgitte & Olsen, Inge Christoffer [Show all 12 contributors for this article] (2017). Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis. Annals of the Rheumatic Diseases. ISSN 0003-4967. 76(12), p. 2031–2037. doi: 10.1136/annrheumdis-2017-211695.
• Michelsen, Brigitte; Kristianslund, Eirik; Sexton, Joseph; Hammer, Hilde Berner; Fagerli, Karen Minde & Lie, Elisabeth [Show all 12 contributors for this article] (2017). Do depression and anxiety reduce the likelihood of remission in rheumatoid arthritis and psoriatic arthritis? Data from the prospective multicentre NOR-DMARD study. Annals of the Rheumatic Diseases. ISSN 0003-4967. 76(11), p. 1906–1910. doi: 10.1136/annrheumdis-2017-211284.
• Hammer, Hilde Berner; Kvien, Tore Kristian & Terslev, Lene (2017). Ultrasound of the hand is sufficient to detect subclinical inflammation in rheumatoid arthritis remission: A post hoc longitudinal study. Arthritis Research & Therapy. ISSN 1478-6354. 19(1). doi: 10.1186/s13075-017-1428-4.
• Magnusson, Karin; Mathiessen, Alexander; Hammer, Hilde Berner; Kvien, Tore Kristian; Christensen, Barbara Therese Slatkovsky & Natvig, Bård [Show all 9 contributors for this article] (2017). Smoking and alcohol use are associated with structural and inflammatory hand osteoarthritis features. Scandinavian Journal of Rheumatology. ISSN 0300-9742. 46(5), p. 388–395. doi: 10.1080/03009742.2016.1257736.

View all works in Cristin

• Gløersen, Marthe; Steen Pettersen, Pernille; Maugesten, Øystein Gunnar; Mulrooney, Elisabeth; Mathiessen, Alexander & Gammelsrud, Heidi [Show all 14 contributors for this article] (2024). Corrigendum to “Study protocol for the follow-up examination of the Nor-Hand study: A hospital-based observational cohort study exploring pain and biomarkers in people with hand osteoarthritis” [Osteoarthr. Cartil. Open 3 (2021) 100198] (Osteoarthritis and Cartilage Open (2021) 3(3), (S2665913121000613), (10.1016/j.ocarto.2021.100198)). Osteoarthritis and Cartilage Open. ISSN 2665-9131. 6(1). doi: 10.1016/j.ocarto.2022.100274.
• Hammer, Hilde Berner (2023). God effekt mot fibromyalgi kommentar fra oss om farmakologi. [Newspaper]. Dagbladet online og papirutgave.
• Hammer, Hilde Berner (2023). Pasienter med fibromyalgi fikk mindre smerter etter terapi. [Internet]. Forskning.no.
• Hammer, Hilde Berner (2023). Avliver 6 artrosemyter. [Newspaper]. VG online og papirutgave.
• Delcoigne, Bénédicte; Provan, Sella Aarrestad; Hammer, Hilde Berner; Di Giuseppe, Daniela; Frisell, Thomas & Glintborg, Bente [Show all 13 contributors for this article] (2022). Erratum: Correction to: Do patient-reported measures of disease activity in rheumatoid arthritis vary between countries? Results from a Nordic collaboration (Rheumatology (Oxford, England) (2022) 61 11 (4286-4296)). Rheumatology. ISSN 1462-0324. 61(12). doi: 10.1093/rheumatology/keac151.
• Christiansen, Sara Nysom; Hammer, Hilde Berner; Torp-Pedersen, Søren & Terslev, Lene (2021). Comment on: Dual-energy computed tomography vs ultrasound, alone or combined, for the diagnosis of gout: A prospective study of accuracy. Rheumatology. ISSN 1462-0324. 60(10), p. E367–E368. doi: 10.1093/rheumatology/keab243.
• Maugesten, Øystein Gunnar; Mathiessen, Alexander; Hammer, Hilde Berner; Hestetun, Sigrid Valen; Kvien, Tore Kristian & Uhlig, Till [Show all 8 contributors for this article] (2021). Correction to: Validity and diagnostic performance of fluorescence optical imaging measuring synovitis in hand osteoarthritis: baseline results from the Nor-Hand cohort. Arthritis Research & Therapy. ISSN 1478-6354. 23. doi: 10.1186/s13075-021-02469-z.
• Sundlisæter, Nina Beate Paulshus; Aga, Anna-Birgitte; Olsen, Inge Christoffer; Hammer, Hilde Berner; Uhlig, Till & van der Heijde, Désirée [Show all 9 contributors for this article] (2021). Joint tenderness and ultrasound inflammation in DMARD-naïve patients with early rheumatoid arthritis. Annals of the Rheumatic Diseases. ISSN 0003-4967. doi: 10.1136/annrheumdis-2021-220265.
• Terslev, Lene; Østergaard, Mikkel; Sexton, Joseph & Hammer, Hilde Berner (2020). Synovial hypertrophy without Doppler in the feet changes during treatment: Results from a longitudinal study of rheumatoid arthritis patients initiating biological treatment. Rheumatology. ISSN 1462-0324. 59(7), p. 1765–1767. doi: 10.1093/rheumatology/kez607.
• Terslev, Lene; Østergaard, Mikkel; Sexton, Joseph & Hammer, Hilde Berner (2020). Erratum: Synovial hypertrophy without Doppler in the feet changes during treatment: Results from a longitudinal study of rheumatoid arthritis patients initiating biological treatment (Rheumatology (2020) 59 (1765–1767) DOI: 10.1093/rheumatology/kez607). Rheumatology. ISSN 1462-0324. 59(7). doi: 10.1093/rheumatology/keaa024.
• Hammer, Hilde Berner; Karoliussen, Lars Fridtjof; Terslev, Lene; Haavardsholm, Espen A.; Kvien, Tore Kristian & Uhlig, Till (2020). Response to: € Correspondence on € Ultrasound shows rapid reduction of crystal depositions during a treat-to-target approach in gout patients: 12-month results from the NOR-Gout study'' by Hung et al. Annals of the Rheumatic Diseases. ISSN 0003-4967. doi: 10.1136/annrheumdis-2020-218908.
• Jonsson, Maria Karolina; Sundlisæter, Nina Beate Paulshus; Nordal, Hilde Haugedal; Hammer, Hilde Berner; Aga, Anna-Birgitte & Heijde, Desirée van der [Show all 10 contributors for this article] (2018). Response to: 'Calprotectin is not independent from baseline erosion in predicting radiological progression in early rheumatoid arthritis' by Chevreau et al. Annals of the Rheumatic Diseases. ISSN 0003-4967. doi: 10.1136/annrheumdis-2017-212869.
• Gaffo, Angelo L.; Dalbeth, Nicola; Saag, Kenneth G.; Singh, Jasvinder A.; Rahn, Elizabeth J. & Mudano, Amy S. [Show all 27 contributors for this article] (2018). Brief Report: Validation of a Definition of Flare in Patients With Established Gout. Arthritis & Rheumatology. ISSN 2326-5191. 70(3), p. 462–467. doi: 10.1002/art.40381.
• Mathiessen, Alexander; Christensen, Barbara Therese Slatkovsky; Kvien, Tore Kristian; Hammer, Hilde Berner & Haugen, Ida Kristin (2017). Response to Does inflammation predict radiographic progression in hand osteoarthritis?' by Li et al. Annals of the Rheumatic Diseases. ISSN 0003-4967. 76(7), p. e21–e21. doi: 10.1136/annrheumdis-2016-210909.

View all works in Cristin