Ida Elken Sønderby

• Akdeniz, Bayram Cevdet ; Frei, Oleksandr; Hagen, Espen; Filiz, Tahir Tekin; Karthikeyan, Sandeep & Pasman, Joëlle [Show all 18 contributors for this article] (2024). COSGAP: COntainerized Statistical Genetics Analysis Pipelines. Bioinformatics Advances. ISSN 2635-0041. 4(1). doi: 10.1093/bioadv/vbae067.
• Beck, Dani; de Lange, Ann-Marie Glasø; Gurholt, Tiril Pedersen; Voldsbekk, Irene; Maximov, Ivan & Subramaniapillai, Sivaniya [Show all 19 contributors for this article] (2024). Dissecting unique and common variance across body and brain health indicators using age prediction. Human Brain Mapping. ISSN 1065-9471. 45(6). doi: 10.1002/hbm.26685.
• Kopal, Jakub; Kumar, Kuldeep; Shafighi, Kimia; Saltoun, Karin; Modenato, Claudia & Moreau, Clara A. [Show all 30 contributors for this article] (2024). Using rare genetic mutations to revisit structural brain asymmetry. Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-46784-w.
• Gurholt, Tiril Pedersen; Borda, Miguel Germán; Parker, Nadine; Fominykh, Vera; Kjelkenes, Rikka & Linge, Jennifer [Show all 12 contributors for this article] (2024). Linking sarcopenia, brain structure and cognitive performance: a large-scale UK Biobank study. Brain Communications. ISSN 2632-1297. 6(2). doi: 10.1093/braincomms/fcae083.
• Koch, Elise Mirjam; Pardiñas, Antonio F.; O'Connell, Kevin Sean; Selvaggi, Pierluigi; Camacho-Collados, Jose & Babic, Aleksandar [Show all 26 contributors for this article] (2024). How real-world data can facilitate the development of precision medicine treatment in psychiatry. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2024.01.001.
• Bøen, Rune; Kaufmann, Tobias Herbert; van der Meer, Dennis; Frei, Oleksandr; Agartz, Ingrid & Ames, David [Show all 53 contributors for this article] (2023). Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers. Biological Psychiatry. ISSN 0006-3223. 95(2), p. 147–160. doi: 10.1016/j.biopsych.2023.08.018. Full text in Research Archive
• Kumar, Kuldeep; Modenato, Claudia; Moreau, Clara; Ching, Christopher R.K.; Harvey, Annabelle & Martin-Brevet, Sandra [Show all 41 contributors for this article] (2023). Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants. American Journal of Psychiatry. ISSN 0002-953X. 180(9), p. 685–698. doi: 10.1176/appi.ajp.20220304.
• Kopal, Jakub; Kumar, Kuldeep; Saltoun, Karin; Modenato, Claudia; Moreau, Clara A. & Martin-Brevet, Sandra [Show all 32 contributors for this article] (2023). Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence. Nature Human Behaviour. ISSN 2397-3374. doi: 10.1038/s41562-023-01541-9.
• Oddsson, Asmundur; Sulem, Patrick; Sveinbjornsson, Gardar; Arnadottir, Gudny A.; Steinthorsdottir, Valgerdur & Halldorsson, Gisli H. [Show all 54 contributors for this article] (2023). Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality. Nature Communications. ISSN 2041-1723. 14. doi: 10.1038/s41467-023-38951-2. Full text in Research Archive
• Birkenæs, Viktoria; Bakken, Nora Refsum; Frei, Evgeniia; Jaholkowski, Piotr Pawel; Smeland, Olav Bjerkehagen & Woldeyohannes, Markos Tesfaye [Show all 15 contributors for this article] (2023). Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men. Schizophrenia Bulletin. ISSN 0586-7614. 49(5), p. 1229–1238. doi: 10.1093/schbul/sbad074. Full text in Research Archive
• Bøen, Rune; Kaufmann, Tobias; Frei, Oleksandr; van der Meer, Dennis; Djurovic, Srdjan & Andreassen, Ole [Show all 9 contributors for this article] (2023). No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank. Translational Psychiatry. ISSN 2158-3188. 13:61, p. 1–6. doi: 10.1038/s41398-023-02358-w. Full text in Research Archive
• van der Meer, Dennis; Gurholt, Tiril Pedersen; Sønderby, Ida Elken; Shadrin, Alexey; Hindley, Guy Frederick Lanyon & Rahman, Zillur [Show all 18 contributors for this article] (2022). The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition. Communications Biology. ISSN 2399-3642. 5(1). doi: 10.1038/s42003-022-04237-4. Full text in Research Archive
• Granerud, Guro; Elvsåshagen, Torbjørn; Arntzen, Erik; Juhasz, Katalin; Emilsen, Nina Merete & Sønderby, Ida Elken [Show all 8 contributors for this article] (2022). A family study of symbolic learning and synaptic plasticity in autism spectrum disorder. Frontiers in Human Neuroscience. ISSN 1662-5161. 16. doi: 10.3389/fnhum.2022.950922. Full text in Research Archive
• Modenato, Claudia; Martin-Brevet, Sandra; Moreau, Clara; Rodriguez-Herreros, Borja; Kumar, Kuldeep & Draganski, Bogdan [Show all 8 contributors for this article] (2021). Lessons learned from neuroimaging studies of copy number variants: A systematic review. Biological Psychiatry. ISSN 0006-3223. 90(9), p. 596–610. doi: 10.1016/j.biopsych.2021.05.028. Full text in Research Archive
• Sønderby, Ida Elken; Ching, Christopher R. K.; Thomopoulos, Sophia I.; van der Meer, Dennis; Sun, Daqiang & Villalon-Reina, Julio E. [Show all 52 contributors for this article] (2021). Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Human Brain Mapping. ISSN 1065-9471. 43, p. 470–499. doi: 10.1002/hbm.25354. Full text in Research Archive
• Sønderby, Ida Elken; van der Meer, Dennis; Moreau, Clara; Kaufmann, Tobias; Walters, G. Bragi & Ellegaard, Maria [Show all 76 contributors for this article] (2021). 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry. ISSN 2158-3188. 11. doi: 10.1038/s41398-021-01213-0. Full text in Research Archive
• O'Connell, Kevin S.; Sønderby, Ida Elken; Frei, Oleksandr; van der Meer, Dennis; Athanasiu, Lavinia & Smeland, Olav Bjerkehagen [Show all 13 contributors for this article] (2021). Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank. Psychological Medicine. ISSN 0033-2917. p. 1–11. doi: 10.1017/S0033291721000179. Full text in Research Archive
• Gurholt, Tiril Pedersen; Kaufmann, Tobias; Frei, Oleksandr; Alnæs, Dag; Haukvik, Unn Kristin H. & van der Meer, Dennis [Show all 17 contributors for this article] (2021). Population-based body–brain mapping links brain morphology with anthropometrics and body composition. Translational Psychiatry. ISSN 2158-3188. doi: 10.1038/s41398-021-01414-7. Full text in Research Archive
• Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang & Li, Shuo [Show all 51 contributors for this article] (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nature Communications. ISSN 2041-1723. 11. doi: 10.1038/s41467-020-18367-y. Full text in Research Archive
• Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita & Hibar, DP [Show all 50 contributors for this article] (2020). The genetic architecture of the human cerebral cortex. Science. ISSN 0036-8075. 367(6484). doi: 10.1126/science.aay6690. Full text in Research Archive Show summary

  INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.

• Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng & Alnæs, Dag [Show all 40 contributors for this article] (2020). Genetic control of variability in subcortical and intracranial volumes. Molecular Psychiatry. ISSN 1359-4184. p. 1–8. doi: 10.1038/s41380-020-0664-1. Full text in Research Archive
• Thompson, Paul M.; Jahanshad, Neda; Ching, Christopher R.K.; Salminen, Lauren E.; Thomopoulos, Sophia I. & Bright, Joanna [Show all 170 contributors for this article] (2020). ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Translational Psychiatry. ISSN 2158-3188. 10:100, p. 1–28. doi: 10.1038/s41398-020-0705-1. Full text in Research Archive
• Gudmundsson, Ólafur Ó.; Walters, Gudmundur Bragi; Ingason, Andrés; Johansson, Stefan; Zayats, Tetyana & Athanasiu, Lavinia [Show all 27 contributors for this article] (2019). Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder. Translational Psychiatry. ISSN 2158-3188. 9, p. 1–9. doi: 10.1038/s41398-019-0599-y. Full text in Research Archive
• van der Meer, Dennis; Sønderby, Ida Elken; Kaufmann, Tobias; Walters, G. Bragi; Abdellaoui, Abdel & Ames, David [Show all 132 contributors for this article] (2019). Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA psychiatry. ISSN 2168-6238. doi: 10.1001/jamapsychiatry.2019.3779. Show summary

  IMPORTANCE: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. OBJECTIVE: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. DESIGN, SETTING, AND PARTICIPANTS: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. MAIN OUTCOMES AND MEASURES: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. RESULTS: Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks. CONCLUSIONS AND RELEVANCE: These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders

• Sønderby, Ida Elken; Gustafsson, Omar; Doan, Nhat Trung; Hibar, Derrek; Martin-Brevet, Sandra & Espeseth, Thomas [Show all 15 contributors for this article] (2018). Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Molecular Psychiatry. ISSN 1359-4184. p. 1–16. doi: 10.1038/s41380-019-0358-8. Full text in Research Archive
• van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir & Alnæs, Dag [Show all 54 contributors for this article] (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry. ISSN 1359-4184. p. 1–13. doi: 10.1038/s41380-018-0262-7. Full text in Research Archive
• Hughes, Timothy; Sønderby, Ida Elken; Polushina, Tatiana; Hansson, Lars Johan Axel; Holmgren, Asbjørn & Athanasiu, Lavinia [Show all 24 contributors for this article] (2018). Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder. Translational Psychiatry. ISSN 2158-3188. 8(210), p. 1–10. doi: 10.1038/s41398-018-0175-x. Full text in Research Archive
• Còrdova Palomera, Aldo; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung & van der Meer, Dennis [Show all 12 contributors for this article] (2018). Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories. European Journal of Human Genetics. ISSN 1018-4813. 26(7), p. 1049–1059. doi: 10.1038/s41431-018-0134-2.
• Stokowy, Tomasz; Polushina, Tatiana; Sønderby, Ida Elken; Karlsson, Robert; Giddaluru, Sudheer & Le Hellard, Stephanie [Show all 12 contributors for this article] (2018). Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes. Scientific Reports. ISSN 2045-2322. 8(6915), p. 1–8. doi: 10.1038/s41598-018-25280-4. Full text in Research Archive
• Hughes, Timothy; Hansson, Lars Johan Axel; Sønderby, Ida Elken; Athanasiu, Lavinia; Zuber, Verena & Tesli, Martin Steen [Show all 13 contributors for this article] (2015). A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2015.09.021.
• Athanasiu, Lavinia; Smorr, Lisa-Lena H; Tesli, Martin Steen; Røssberg, Jan Ivar; Sønderby, Ida Elken & Spigset, Olav [Show all 8 contributors for this article] (2015). Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs. Journal of Psychopharmacology. ISSN 0269-8811. 29(8), p. 884–891. doi: 10.1177/0269881115584469.
• Goulart, Luiz Fernando De Souza; Bettella, Franscesco; Sønderby, Ida Elken; Schork, Andrew J.; Thompson, Kurt Wesley & Mattingsdal, Morten [Show all 12 contributors for this article] (2015). MicroRNAs enrichment in GWAS of complex human phenotypes. BMC Genomics. ISSN 1471-2164. 16:304. doi: 10.1186/s12864-015-1513-5. Full text in Research Archive
• Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta & Tamnes, Christian Krog [Show all 15 contributors for this article] (2015). Genome-wide analysis of attention deficit hyperactivity disorder in Norway. PLOS ONE. ISSN 1932-6203. 10(4). doi: 10.1371/journal.pone.0122501. Full text in Research Archive
• Zai, Clement C; Manchia, M; Sønderby, Ida Elken; Yilmaz, Z.; De Luca, Valeria & Tiwari, AK [Show all 19 contributors for this article] (2015). Investigation of the genetic interaction between BDNF and DRD3 genes in suicidical behaviour in psychiatric disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. 16(3), p. 171–179. doi: 10.3109/15622975.2014.953011.
• Finseth, Per Ivar; Sønderby, Ida Elken; Djurovic, Srdjan; Agartz, Ingrid; Malt, Ulrik Fredrik & Melle, Ingrid [Show all 10 contributors for this article] (2014). Association analysis between suicidal behaviour and candidate genes of bipolar disorder and schizophrenia. Journal of Affective Disorders. ISSN 0165-0327. 163, p. 110–114. doi: 10.1016/j.jad.2013.12.018. Full text in Research Archive
• Tesli, Martin Steen; Egeland, Randi; Sønderby, Ida Elken; Haukvik, Unn Kristin H.; Bettella, Franscesco & Hibar, Derrek [Show all 12 contributors for this article] (2013). No evidence for association between bipolar disorder risk gene variants and brain structural phenotypes. Journal of Affective Disorders. ISSN 0165-0327. 151(1), p. 291–297. doi: 10.1016/j.jad.2013.06.008.
• Mattingsdal, Morten; Brown, Andrew; Djurovic, Srdjan; Sønderby, Ida Elken; ALONSO, ANDRES SERVER & Melle, Ingrid [Show all 10 contributors for this article] (2013). Pathway analysis of genetic markers associated with a functional MRI faces paradigm implicates polymorphisms in calcium responsive pathways. NeuroImage. ISSN 1053-8119. 70, p. 143–149. doi: 10.1016/j.neuroimage.2012.12.035.
• Wirgenes, Katrine Verena; Sønderby, Ida Elken; Haukvik, Unn Kristin H.; Mattingsdal, Morten; Tesli, Martin Steen & Athanasiu, Lavinia [Show all 14 contributors for this article] (2012). TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders. Translational Psychiatry. ISSN 2158-3188. 2(e112). doi: 10.1038/tp.2012.39.

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• Kopal, Jakub; Kumar, Kuldeep; Shafighi, Kimia; Saltoun, Karin; Modenato, Claudia & Moreau, Clara A. [Show all 30 contributors for this article] (2024). Correction to: Using rare genetic mutations to revisit structural brain asymmetry (Nature Communications, (2024), 15, 1, (2639), 10.1038/s41467-024-46784-w). Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-024-47545-5.
• Birkenæs, Viktoria; Shadrin, Alexey; Parekh, Pravesh; Frei, Evgeniia; Havdahl, Alexandra & Andreassen, Ole [Show all 7 contributors for this article] (2023). Self-Reported Psychotic Experiences: Does an Unreliable Phenotypic Measure Introduce Bias in Genetic Associations?
• Birkenæs, Viktoria; Shadrin, Alexey; Frei, Evgeniia; Parekh, Pravesh; Jaholkowski, Piotr Pawel & Smeland, Olav Bjerkehagen [Show all 9 contributors for this article] (2023). Genome-Wide Analysis of Self-Reported Psychotic Experiences in the Norwegian Mother, Father, and Child study.
• Akdeniz, Bayram Cevdet ; Bøen, Rune; Frei, Oleksandr; Hovig, Eivind; Andreassen, Ole & Sønderby, Ida Elken (2022). LARGE-SCALE ANALYSIS WITH SOFTWARE CONTAINERS IN ENIGMA-CNV–AN INTERNATIONAL WORKING GROUP TO STUDY RECURRENT COPY NUMBER VARIANTS AND BRAIN MEASURES. Neuropsychopharmacology, 2022.
• Sønderby, Ida Elken (2017). Update, ENIGMA-CNV - from genes to phenotypes to brain structures.
• Sønderby, Ida Elken (2017). The 16p11.2 Distal Copy Number Variant Conveys Dose-Response Effects on Intracranial Volume and Structures of the Basal ganglia: A Mega-Analysis from the Enigma-CNV Working Group.
• Sønderby, Ida Elken (2016). ENIGMA-CNV - a genetics-MR-project - finding the needle in the haystack.
• Sønderby, Ida Elken (2016). Coupling subcortical brain volumes with CNVs: A preliminary mega-analysis in ENIGMA-CNV.
• Córdova-Palomera, Aldo; Bettella, Francesco; Wang, Yunpeng; Doan, Nhat Trung; Alnæs, Dag & Moberget, Torgeir [Show all 11 contributors for this article] (2016). POTENTIAL BRAIN MORPHOLOGY INSTABILITY FEATURES MEDIATING THE ASSOCIATION BETWEEN GENOME-WIDE HOMOZYGOSITY AND ALTERED NEUROCOGNITION.
• Sønderby, Ida Elken (2016). Association of subcortical brain volumes with CNVs: A mega-analysis from the ENIGMA-CNV working group.
• Sønderby, Ida Elken (2015). ENIGMA CNV working group: Coupling subcortical brain volumes with CNVs in healthy and patient populations.

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