Johannes Lagethon Bjørnstad

• Røed-Undlien, Henriette; Schultz, Nina Haagenrud; Amundsen, Erik Koldberg; Wollmann, Birgit Malene Tovik; Molden, Espen & Akerkar, Rupali Rajendra [Show all 7 contributors for this article] (2024). Does in vitro hemolysis affect measurements of plasma apixaban concentration by UPLC-MS and anti-Xa assay? International Journal of Laboratory Hematology (IJLH). ISSN 1751-5521. doi: 10.1111/ijlh.14311.
• Mortensen, Michael; Nilsen, Roy Miodini; Kvalheim, Venny Lise; BJØRNSTAD, JOHANNES; Svendsen, Øyvind Sverre & Haaverstad, Rune [Show all 7 contributors for this article] (2023). The influence of socio-demographic and clinical factors on sick leave and return to work after open-heart surgery: a nationwide registry-based cohort study. European Heart Journal - Quality of Care and Clinical Outcomes. ISSN 2058-5225. p. 1–14. doi: 10.1093/ehjqcco/qcad064. Full text in Research Archive Show summary

  Aims To estimate sick leave (SL) duration after first-time elective open-heart surgery and identify factors contributing to increased SL. Methods and results A retrospective nationwide cohort study combined data from the Norwegian Register for Cardiac Surgery and SL data from the Norwegian Labour and Welfare Administrations. All able-bodied adults who underwent first-time elective open-heart surgery in Norway between 2012 and 2021 were followed until 1 year after surgery. The impact of socio-demographic and clinical factors on SL after surgery was analysed using logistic regression and odds ratios. Of 5456 patients, 1643 (30.1%), 1798 (33.0%), 971 (17.8%), 1035 (18.9%), and 9 (0.2%) had SL of <3, 3–6, 6–9, and 9–12 months, and 1 year, respectively. SL >6 months was associated with female gender, primary education only, and average annual income. Post-operative stroke, post-operative renal failure, New York Heart Association Functional Classification system (NYHA) score >3, earlier myocardial infarction, and diabetes mellitus increased the odds of SL >6 months. Conclusion This study demonstrates that socio-demographic and clinical factors impact SL after first-time elective open-heart surgery. Patients who experience a stroke or develop renal failure after surgery have the highest odds of SL >6 months. Females and patients with low education levels, earlier myocardial infarction, or NYHA scores III–IV have a two-fold chance of SL >6 months. The findings allow for future investigations of pre- and post-surgery interventions that can most effectively reduce SL and aid return to work.

• Røed-Undlien, Henriette; Schultz, Nina Haagenrud; Lunnan, Asbjørn; Husebråten, Inger; Wollmann, Birgit Malene Tovik & Molden, Espen [Show all 7 contributors for this article] (2022). In Vitro Apixaban Removal By CytoSorb Whole Blood Adsorber: An Experimental Study. Journal of Cardiothoracic and Vascular Anesthesia. ISSN 1053-0770. 36(6), p. 1636–1644. doi: 10.1053/j.jvca.2022.01.038. Full text in Research Archive
• Bjørnstad, Johannes Lagethon; Helgeland, Erik; Geiran, Odd & Fiane, Arnt Eltvedt (2020). Er EXCEL studien relevant for norske forhold? . Hjerteforum. ISSN 0802-1465. 33(3), p. 22–28.
• Helgeland, Erik; Andresen, Kristoffer; Dumont, Karl-Andreas & BJØRNSTAD, JOHANNES (2020). Leaflet fracture and embolization from an On-X mechanical mitral valve. JTCVS Techniques. ISSN 2666-2507. p. 140–143. doi: 10.1016/j.xjtc.2020.06.021.
• Bjørnstad, Johannes; Khan, Adil Mahboob; Røed-Undlien, Henriette; Bendz, Bjørn; Nygård, Ståle & Nilsen-Hoel, Tom [Show all 7 contributors for this article] (2020). Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants. Open heart. ISSN 2053-3624. 7:e001278(2), p. 1–9. doi: 10.1136/openhrt-2020-001278. Full text in Research Archive
• Nuru, Abdul; Hagesveen Weltzien, Joachim; Sandvik, Leiv; Tønnessen, Theis & BJØRNSTAD, JOHANNES (2019). Short- and long-term survival after isolated coronary artery bypass grafting, the impact of gender and age. Scandinavian Cardiovascular Journal. ISSN 1401-7431. p. 1–6. doi: 10.1080/14017431.2019.1646430. Full text in Research Archive
• Skrbic, Biljana; Engebretsen, Kristin V Thunheim; Strand, Mari Elen; Lunde, Ida Gjervold; Herum, Kate Louise Møller & Marstein, Henriette [Show all 12 contributors for this article] (2015). Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice. Cardiovascular Research (CVR). ISSN 0008-6363. 106(1), p. 32–42. doi: 10.1093/cvr/cvv041.
• Majak, Piotr; Lunde, Ida Gjervold; Hasic, Almira; Husebye, Trygve Guttorm; Christensen, Geir Arve & Tønnessen, Theis [Show all 7 contributors for this article] (2015). Reduced visfatin levels in aortic stenosis increase after aortic valve replacement and may contribute to reverse left ventricular remodelling. Journal of Cardiovascular Surgery. ISSN 0021-9509. 56(3), p. 483–492.
• Engebretsen, Kristin V Thunheim; Skårdal, Kristine; Bjørnstad, Sigrid; Marstein, Henriette; Skrbic, Biljana & Sjaastad, Ivar [Show all 9 contributors for this article] (2014). Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 76, p. 148–157. doi: 10.1016/j.yjmcc.2014.08.008.
• Nygård, Ståle; Reitan, Trond; Clancy, Trevor; Nygaard, Vegard; BJØRNSTAD, JOHANNES & Skrbic, Biljana [Show all 9 contributors for this article] (2014). Identifying pathogenic processes by integrating microarray data with prior knowledge. BMC Bioinformatics. ISSN 1471-2105. 15(1). doi: 10.1186/1471-2105-15-115. Full text in Research Archive
• Engebretsen, Kristin V Thunheim; Lunde, Ida Gjervold; Strand, Mari Elen; Sjaastad, Ivar; Marstein, Henriette & Skrbic, Biljana [Show all 12 contributors for this article] (2013). Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli. The FEBS Journal. ISSN 1742-464X. 280(10), p. 2382–2398. doi: 10.1111/febs.12235.
• Engebretsen, Kristin V Thunheim; Wæhre, Anne; BJØRNSTAD, JOHANNES; Skrbic, Biljana; Sjaastad, Ivar & Behmen, Dina [Show all 11 contributors for this article] (2013). Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse. Journal of applied physiology. ISSN 8750-7587. 114(8), p. 988–997. doi: 10.1152/japplphysiol.00793.2012.
• Skrbic, Biljana; BJØRNSTAD, JOHANNES; Marstein, Henriette; Carlson, Cathrine Rein; Sjaastad, Ivar & Nygård, Ståle [Show all 9 contributors for this article] (2013). Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload. Matrix Biology. ISSN 0945-053X. 32(2), p. 133–142. doi: 10.1016/j.matbio.2012.11.011.
• Majak, Piotr; BJØRNSTAD, JOHANNES; Braathen, Bjørn; Lunde, Ida Gjervold; Husebye, Trygve Guttorm & Christensen, Geir Arve [Show all 7 contributors for this article] (2012). Endothelin-1 in the Human Myocardium and Circulating Plasma: Evaluation before, during and after Correction of Aortic Stenosis with Aortic Valve Replacement. Cardiology. ISSN 0008-6312. 123(1), p. 1–10. doi: 10.1159/000339756.
• Majak, Piotr; Braathen, Bjørn; BJØRNSTAD, JOHANNES & Tønnessen, Theis (2012). GDF-15 is increased during early reperfusion following aortic valve replacement. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 46(2), p. 99–106. doi: 10.3109/14017431.2011.649489.
• BJØRNSTAD, JOHANNES; Skrbic, Biljana; Marstein, Henriette; Hasic, Almira; Sjaastad, Ivar & Louch, William Edward [Show all 9 contributors for this article] (2012). Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload. Cardiovascular Research (CVR). ISSN 0008-6363. 93(1), p. 100–110. doi: 10.1093/cvr/cvr294.
• Bjørnstad, Johannes L.; Skrbic, Biljana; Sjaastad, Ivar; Bjørnstad, Sigrid; Christensen, Geir Arve & Tønnessen, Theis (2012). A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta. Acta Physiologica. ISSN 1748-1708. 205(1), p. 92–102. doi: 10.1111/j.1748-1716.2011.02369.x.
• BJØRNSTAD, JOHANNES; Sjaastad, Ivar; Nygård, Ståle; Hasic, Almira; Ahmed, Muhammad Shakil & Attramadal, Håvard [Show all 9 contributors for this article] (2011). Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload. European Heart Journal. ISSN 0195-668X. 32(2), p. 236–245. doi: 10.1093/eurheartj/ehq166.
• Majak, Piotr; Bjørnstad, Johannes; Vengen, Øystein; Neverdal, Nils Olav; Husebye, Trygve & Woldbæk, Per R [Show all 10 contributors for this article] (2010). Plasma IL-18 and IL-18BP are altered differently in reverse remodeling following aortic valve replacement. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 44(2), p. 113–118. doi: 10.3109/14017430903426902.
• Bjørnstad, Johannes; Pillgram-Larsen, Johan & Tønnessen, Theis (2009). Coronary artery dissection and acute myocardial infarction following blunt chest trauma. World Journal of Emergency Surgery. ISSN 1749-7922. 14(4).
• Bjørnstad, Johannes; Neverdal, Nils Olav; Vengen, Øystein; Knudsen, Cathrine Wold; Husebye, Trygve & Pepper, John [Show all 9 contributors for this article] (2008). Alterations in circulating activin A, GDF-15, TGF-beta 3 and MMP-2,-3, and-9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis. European Journal of Heart Failure. ISSN 1388-9842. 10(12), p. 1201–1207. doi: 10.1016/j.ejheart.2008.09.010.

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• Røed-Undlien, Henriette; Schultz, Nina Haagenrud; Lunnan, Asbjørn; Husebråten, Inger Marie; Wollmann, Birgit Malene Tovik & Molden, Espen [Show all 7 contributors for this article] (2024). Corrigendum to < IN-VITRO APIXABAN REMOVAL BY CYTOSORB® WHOLE BLOOD ADSORBER. AN EXPERIMENTAL STUDY.> <[Journal of Cardiothoracic and Vascular Anesthesia 36/6 (2024) 1636 – 1644]> (Journal of Cardiothoracic and Vascular Anesthesia (2022) 36(6) (1636–1644), (S1053077022000726), (10.1053/j.jvca.2022.01.038)). Journal of Cardiothoracic and Vascular Anesthesia. ISSN 1053-0770. doi: 10.1053/j.jvca.2024.03.039.
• Mortensen, Michael; Nilsen, Roy Miodini; Kvalheim, Venny Lise; BJØRNSTAD, JOHANNES; Svendsen, Øyvind Sverre & Haaverstad, Rune [Show all 7 contributors for this article] (2023). The impact of clinical and sociodemographic factors on sick leave after cardiac surgery .
• Abu Afifi, Rim; Lundblad, Runar & Bjørnstad, Johannes Lagethon (2022). Resultater etter kirurgisk behandling av atrieflimmer. Hjerteforum. ISSN 0802-1465. 35(4), p. 27–36.
• Mortensen, Michael; Nilsen, Roy Miodini; Kvalheim, Venny Lise; BJØRNSTAD, JOHANNES; Svendsen, Øyvind Sverre & Haaverstad, Rune [Show all 7 contributors for this article] (2022). Kliniske og sosiodemografiske faktorer som fører til lengre sykemelding etter hjertekirurgi.
• Bjørnstad, Johannes Lagethon; Helgeland, Erik; Geiran, Odd & Fiane, Arnt Eltvedt (2021). Hjertekirurgi og hjerneskade. Hjerteforum. ISSN 0802-1465. 34(2), p. 104–105.
• Bjørnstad, Johannes & Bendz, Bjørn (2020). Periprocedural myocardial injury in the EXCEL trial. European Heart Journal. ISSN 0195-668X. 41(17). doi: 10.1093/eurheartj/ehaa182.
• Bjørnstad, Johannes Lagethon; Fiane, Arnt Eltvedt; Svennevig, Jan Ludvig & Geiran, Odd (2019). Norsk hjertekirurgiregister, et forskriftsregulert nasjonalt medisinsk kvalitetsregister. . Hjerteforum. ISSN 0802-1465. 32(1), p. 42–54.
• Skrbic, Biljana; Engebretsen, Kristin V Thunheim; Strand, Mari Elen; Marstein, Henriette; Sjaastad, Ivar & Lunde, Ida Gjervold [Show all 10 contributors for this article] (2013). Lack of collagen type 8 in pressure overload causes left ventricular dilatation and overt heart failure in mice, suggesting a role in transition to heart failure in patients with aortic stenosis.
• Skrbic, Biljana; Engebretsen, Kristin V Thunheim; Strand, Mari Elen; Marstein, Henriette; Sjaastad, Ivar & Lunde, Ida Gjervold [Show all 10 contributors for this article] (2013). Lack of collagen type 8 in pressure overload causes left ventricular dilatation and overt heart failure in mice, suggesting a role in transition to heart failure in patients with aortic stenosis. Circulation. ISSN 0009-7322. 128.
• Engebretsen, Kristin V Thunheim; Skårdal, Kristine; Bjørnstad, S; Marstein, Henriette; Skrbic, Biljana & Sjaastad, Ivar [Show all 9 contributors for this article] (2013). Inhibiting phosphorylation of SMAD2/3 by the small molecule SM16 in left ventricular pressure overload reduces fibrosis and signs of heart failure, possibly due to better diastolic function.
• Skrbic, Biljana; Engebretsen, Kristin V Thunheim; Marstein, Henriette; Sjaastad, Ivar; Christensen, Geir Arve & BJØRNSTAD, JOHANNES [Show all 7 contributors for this article] (2012). Reduction in collagen type 8 might be involved in transition from compensated hypertrophy to left ventricular dilatation and overt heart failure in pressure overload.
• Engebretsen, Kristin V Thunheim; Lunde, Ida Gjervold; Wæhre, Anne; Strand, Mari Elen; Sjaastad, Ivar & Marstein, Henriette [Show all 11 contributors for this article] (2012). The collagen-organizing proteoglycan lumican is increased in experimental and clinical heart failure and its production by cardiac fibroblasts is induced by pro-inflammatory and mechanical stimuli.
• Engebretsen, Kristin V Thunheim; BJØRNSTAD, JOHANNES; Skrbic, Biljana; Marstein, Henriette; Sjaastad, Ivar & Wæhre, Anne [Show all 8 contributors for this article] (2011). Endret nivå av small leucine rich proteoglycans i en musemodell som etterligner pasienter operert for aortastenose.
• Skrbic, Biljana; BJØRNSTAD, JOHANNES; Marstein, Henriette; Sjaastad, Ivar; Nygård, Ståle & Christensen, Geir Arve [Show all 7 contributors for this article] (2011). Reduksjon i kollagen VIII kan være involvert i venstre ventrikkel dilatasjon og overgang fra kompensert hypertrofi til dekompensert hjertesvikt ved trykkoverbelastning.
• Skrbic, Biljana; BJØRNSTAD, JOHANNES; Marstein, Henriette; Sjaastad, Ivar; Nygård, Ståle & Christensen, Geir Arve [Show all 7 contributors for this article] (2011). Reduction in collagen type 8 might be involved in transition from compensated hypertrophy to left ventricular dilatation and overt heart failure in pressure overload.
• Engebretsen, Kristin V Thunheim; BJØRNSTAD, JOHANNES; Skrbic, Biljana; Marstein, Henriette; Sjaastad, Ivar & Wæhre, Anne [Show all 8 contributors for this article] (2011). Correction of left ventricular pressure overload leads to altered myocardial expression of small leucine rich proteoglycans.
• Nygård, Ståle; Reitan, Trond; Clancy, Trevor; Nygaard, Vegard; BJØRNSTAD, JOHANNES & Tønnessen, Theis [Show all 8 contributors for this article] (2011). Identifying pathogenic signaling and regulatory networks by integrating microarray data with prior knowledge.
• Nygård, Ståle; Reitan, Trond; Clancy, Trevor; Nygaard, Vegard; BJØRNSTAD, JOHANNES & Tønnessen, Theis [Show all 8 contributors for this article] (2011). Identifying pathogenic signaling and regulatory networks by integrating microarray data with prior knowledge.
• Nygård, Ståle; Nygaard, Vigdis; Clancy, Trevor; BJØRNSTAD, JOHANNES; Skrbic, Biljana & Sjaastad, Ivar [Show all 9 contributors for this article] (2010). Integrating microarray gene expression data with prior knowledge about molecular interactions for identification of important heart failure pathways.
• Skrbic, Biljana; BJØRNSTAD, JOHANNES; Marstein, Henriette; Sjaastad, Ivar; Nygård, Ståle & Christensen, Geir Arve [Show all 7 contributors for this article] (2010). Reduction in collagen VIII might be involved in transition from compensated hypertrophy to overt heart failure in pressure overload.
• Nygård, Ståle; Nygaard, Vigdis; Clancy, Trevor; BJØRNSTAD, JOHANNES; Skrbic, Biljana & Tønnessen, Theis [Show all 8 contributors for this article] (2010). Integrating microarray gene expression data with prior knowledge about molecular interactions for identification of important heart failure pathways.
• BJØRNSTAD, JOHANNES; Sjaastad, Ivar; Nygård, Ståle; Finsen, Alexandra; Hasic, Almira & Christensen, Geir Arve (2010). The pro-inflammatory adipocytokine visfatin might play a role regulating cardiac metabolism in human and experimental aortic stenosis. European Journal of Heart Failure. Supplements. ISSN 1567-4215. 9, p. S220–S220.
• BJØRNSTAD, JOHANNES; Skrbic, Biljana; Marstein, Henriette; Sjaastad, Ivar; Louch, William Edward & Christensen, Geir Arve [Show all 7 contributors for this article] (2010). Inhibiting phosphorylation of SMAD2 preserves cardiac function during pressure overload by attenuating left ventricular SERCA2 loss.
• BJØRNSTAD, JOHANNES; Skrbic, Biljana; Marstein, Henriette; Sjaastad, Ivar; Christensen, Geir Arve & Tønnessen, Theis (2009). Inhibiting phosphorylation of SMAD2 preserves cardiac function during pressure overload. Circulation. ISSN 0009-7322. 120, p. S857–S857.
• BJØRNSTAD, JOHANNES; Sjaastad, Ivar; Nygård, Ståle; Hasic, Almira; Ahmed, Muhammad Shakil & Attramadal, Håvard [Show all 9 contributors for this article] (2009). Reverse remodeling of the left ventricle during the early phase after relief of pressure overload in a mouse model. European Heart Journal, Supplement. ISSN 1520-765X. 30, p. 218–218.
• BJØRNSTAD, JOHANNES; Sjaastad, Ivar; Nygård, Ståle; Finsen, Alexandra; Hasic, Almira & Attramadal, Håvard [Show all 9 contributors for this article] (2009). Reverse remodeling of the left ventricle during the early phase after relief of pressure overload in a mouse model. Hjerteforum. ISSN 0802-1465. 22, p. 110–110.
• BJØRNSTAD, JOHANNES; Skrbic, Biljana; Marstein, Henriette; Sjaastad, Ivar; Christensen, Geir Arve & Tønnessen, Theis (2009). Inhibiting phosphorylation of SMAD2 preserves cardiac function during pressure overload.
• BJØRNSTAD, JOHANNES; Sjaastad, Ivar; Finsen, Alexandra; Nygård, Ståle; Hasic, Almira & Christensen, Geir Arve (2008). Reversible pressure overload alters expression of actin binding and extracellular matrix genes.
• Bjørnstad, Johannes Lagethon & Tønnessen, Theis (2011). The TGFβ/SMAD signalling system and extracellular matrix changes in myocardial remodelling and reverse remodelling following correction of pressure overload. Unipub forlag. ISSN 9788282641395.

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