Johanne Uthus Hermansen

• Hermansen, Johanne Uthus; Yin, Yanping; Rein, Idun Dale & Skånland, Sigrid S (2024). Immunophenotyping with (phospho)protein profiling and fluorescent cell barcoding for single-cell signaling analysis and biomarker discovery. NPJ precision oncology. ISSN 2397-768X. 8(1). doi: 10.1038/s41698-024-00604-y.
• de Muinck, Eric; Trosvik, Pål; Nguyen, Nga; Fashing, Peter J.; Stigum, Vetle Malmer & Robinson, Nina [Show all 9 contributors for this article] (2023). Reduced abundance of Faecalibacterium prausnitzii in the gut microbiota of children diagnosed with cancer, a pilot study. Frontiers in Mircobiomes. ISSN 2813-4338. 2. doi: 10.3389/frmbi.2023.1151889. Full text in Research Archive
• Ayuda Duran, Pilar; Hermansen, Johanne Uthus; Giliberto, Mariaserena; Yin, Yanping; Hanes, Robert & Gordon, Sandra [Show all 13 contributors for this article] (2023). Standardized assays to monitor drug sensitivity in hematologic cancers. Cell death discovery. ISSN 2058-7716. 9(1), p. 1–13. doi: 10.1038/s41420-023-01722-5. Full text in Research Archive
• Almaas, Runar; Atneosen-Åsegg, Monica; Ytre-Arne, Mari Eknes; Melheim, Maria; Sorte, Hanne Sørmo & Cízková, Dana [Show all 16 contributors for this article] (2023). Aagenaes syndrome/lymphedema cholestasis syndrome 1 is caused by a founder variant in the 5’-untranslated region of UNC45A. Journal of Hepatology. ISSN 0168-8278. 79(4), p. 945–954. doi: 10.1016/j.jhep.2023.05.037. Full text in Research Archive
• Hermansen, Johanne Uthus; Yin, Yanping; Urban, Aleksandra; Myklebust, Camilla Victoria; Karlsen, Linda & Melvold, Katrine [Show all 11 contributors for this article] (2023). A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine. Cell death discovery. ISSN 2058-7716. 9. doi: 10.1038/s41420-023-01426-w. Full text in Research Archive
• Hermansen, Johanne Uthus; Wojcik, Dorota; Robinson, Nina; Pahnke, Jens; Haugland, Hans Kristian & Jamtøy, Ann-Helen [Show all 11 contributors for this article] (2021). The Norwegian childhood cancer biobank. Cancer Reports. ISSN 2573-8348. 0:e1555(8), p. 1–8. doi: 10.1002/cnr2.1555. Full text in Research Archive Show summary

  Background The rapidly expanding era of “omics” research is highly dependent on the availability of quality-proven biological material, especially for rare conditions such as pediatric malignancies. Professional biobanks provide such material, focusing on standardized collection and handling procedures, distinctive quality measurements, traceability of storage conditions, and accessibility. For pediatric malignancies, traditional tumor biobanking is challenging due to the rareness and limited amount of tissue and blood samples. The higher molecular heterogeneity, lower mutation rates, and unique genomic landscapes, however, renders biobanking of this tissue even more crucial. Aim The aim of this study was to test and establish methods for a prospective and centralized biobank for infants, children, and adolescents up to 18 years of age diagnosed with cancer in Norway. Methods Obtain judicial and ethical approvals and administration through a consortium, steering committee, and advisory board. Develop pipelines including SOPs for all aspects in the biobank process, including collection, processing and storing of samples and data, as well of quality controlling, safeguarding, distributing, and transport. Results The childhood cancer biobanking started at Oslo University Hospital in March 2017 and was from 2019 run as a national Norwegian Childhood Cancer Biobank. Informed consent and biological samples are collected regionally and stored centrally. Approximately 12 000 samples from 510 patients and have been included by January 1, 2021, representing a 96% consent and participation rate among our newly diagnosed patients. Conclusion A well-functioning nationwide collection and centralized biobank with standardized procedures and national storage for pediatric malignancies has been established with a high acceptance among families.

• Skjerven, Håvard Ove; Rehbinder, Eva Maria; Vettukattil, Muhammad Riyas; LeBlanc, Marissa Erin; Granum, Berit & Haugen, Guttorm [Show all 35 contributors for this article] (2020). Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial. The Lancet. ISSN 0140-6736. 395(10228), p. 951–961. doi: 10.1016/S0140-6736(19)32983-6. Full text in Research Archive
• Skånland, Sigrid Strand; Cremaschi, Andrea; Bendiksen, Henrik; Hermansen, Johanne Uthus; Thimiri Govinda Raj, Deepak Balaji & Munthe, Ludvig Andre [Show all 8 contributors for this article] (2019). An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL. Leukemia. ISSN 0887-6924. doi: 10.1038/s41375-019-0569-7.
• Hermansen, Johanne Uthus; Tjønnfjord, Geir Erland; Munthe, Ludvig Andre; Tasken, Kjetil & Skånland, Sigrid Strand (2018). Cryopreservation of primary B cells minimally influences their signaling responses. Scientific Reports. ISSN 2045-2322. 8:17651, p. 1–7. doi: 10.1038/s41598-018-36121-9. Full text in Research Archive
• Myhrvold, Ida Kristin; Cremaschi, Andrea; Hermansen, Johanne Uthus; Tjønnfjord, Geir Erland; Munthe, Ludvig Andre & Tasken, Kjetil [Show all 7 contributors for this article] (2018). Single cell profiling of phospho-protein levels in chronic lymphocytic leukemia. OncoTarget. ISSN 1949-2553. 9(10), p. 9273–9284. doi: 10.18632/oncotarget.23949. Full text in Research Archive

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