John Karsten Kjekshus

• Povysil, Gundula; Chazara, Olympe; Carss, Keren J.; Deevi, Sri V. V.; Wang, Quanli & Armisen, Javier [Show all 12 contributors for this article] (2020). Assessing the Role of Rare Genetic Variation in Patients with Heart Failure. JAMA cardiology. ISSN 2380-6583. doi: 10.1001/jamacardio.2020.6500.
• Kotecha, Dipak; Gill, Simrat K.; Flather, Marcus D.; Holmes, Jane; Packer, Milton & Rosano, Giuseppe [Show all 22 contributors for this article] (2019). Impact of renal impairment on beta-blocker efficacy in patients with heart failure. Journal of the American College of Cardiology. ISSN 0735-1097. 74(23), p. 2893–2904. doi: 10.1016/j.jacc.2019.09.059. Full text in Research Archive
• Cleland, John G.F.; Bunting, Karina V.; Flather, Marcus D.; Altman, Douglas G.; Holmes, Jane & Coats, Andrew J.S. [Show all 21 contributors for this article] (2018). Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials. European Heart Journal. ISSN 0195-668X. 39(1), p. 26–35. doi: 10.1093/eurheartj/ehx564.
• Dobre, Daniela; Kjekshus, John; Rossignol, Patrick; Girerd, Nicolas; Bénétos, Athanese & Dickstein, Kenneth [Show all 7 contributors for this article] (2018). Heart rate, pulse pressure and mortality in patients with myocardial infarction complicated by heart failure. International Journal of Cardiology. ISSN 0167-5273. 271, p. 181–185. doi: 10.1016/j.ijcard.2018.05.017.
• Cosmi, Franco; Shen, Li; Magnoli, Michela; Abraham, William T.; Anand, Inder S. & Cleland, John G. [Show all 29 contributors for this article] (2018). Treatment with insulin is associated with worse outcome in patients with chronic heart failure and diabetes. European Journal of Heart Failure. ISSN 1388-9842. 20(5), p. 888–895. doi: 10.1002/ejhf.1146.
• Shen, Li; Jhund, Pardeep S; Petrie, Mark C.; Claggett, Brian L; Barlera, Simona & Cleland, John GF [Show all 21 contributors for this article] (2017). Declining risk of sudden death in heart failure. New England Journal of Medicine. ISSN 0028-4793. 377(1), p. 41–51. doi: 10.1056/NEJMoa1609758.
• Agewall, Stefan; Tjessem, Liv; Rossignol, Patrick; Zannad, Faiez; Atar, Dan & Lamiral, Zohra [Show all 11 contributors for this article] (2017). Heart rate prediction of outcome in heart failure following myocardial infarction depend on heart rhythm status an analysis from the high-risk myocardial infarction database initiative. International Journal of Cardiology. ISSN 0167-5273. 249, p. 274–281. doi: 10.1016/j.ijcard.2017.09.182.
• Kotecha, Dipak; Flather, Marcus D.; Altman, Douglas G.; Holmes, Jane; Rosano, Giuseppe & Wikstrand, John [Show all 18 contributors for this article] (2017). Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure. Journal of the American College of Cardiology. ISSN 0735-1097. 69(24), p. 2885–2896. doi: 10.1016/j.jacc.2017.04.001.
• Nymo, Ståle Haugset; Aukrust, Pål; Kjekshus, John; McMurray, John J.V.; Cleland, John G.F. & Wikstrand, John [Show all 16 contributors for this article] (2017). Limited added value of circulating inflammatory biomarkers in chronic heart failure. JACC. Heart failure. ISSN 2213-1779. 5(4), p. 256–264. doi: 10.1016/j.jchf.2017.01.008.
• Tajik, Athar Ali; Dobre, Daniela; Aguilar, David; Kjekshus, John; Zannad, Faiez & Dickstein, Kenneth (2017). A history of diabetes predicts outcomes following myocardial infarction: an analysis of the 28 771 patients in the High-Risk MI Database. European Journal of Heart Failure. ISSN 1388-9842. 19(5), p. 635–642. doi: 10.1002/ejhf.797.
• Ellingsen, Øyvind; Halle, Martin; Conraads, Viviane; Støylen, Asbjørn; Dalen, Håvard & Delagardelle, Charles [Show all 28 contributors for this article] (2017). High-Intensity Interval Training in Patients with Heart Failure with Reduced Ejection Fraction. Circulation. ISSN 0009-7322. 135(9), p. 839–849. doi: 10.1161/CIRCULATIONAHA.116.022924. Full text in Research Archive
• Arain, Fizza Kanwal; Gullestad, Lars; Nymo, Ståle Haugset; Kjekshus, John; Cleland, JG & Michelsen, Annika [Show all 10 contributors for this article] (2016). Low YKL-40 in chronic heart failure may predict beneficial effects of statins: analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA. Biomarkers. ISSN 1354-750X. 22(3-4), p. 261–267. doi: 10.1080/1354750X.2016.1204003.
• Damman, Kevin; Kjekshus, John; Wikstrand, John; Cleland, John G F; Komajda, Michel & Wedel, Hans [Show all 8 contributors for this article] (2016). Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction. European Journal of Heart Failure. ISSN 1388-9842. 18(3), p. 328–336. doi: 10.1002/ejhf.462.
• Askevold, Erik Tandberg; Gullestad, Lars; Nymo, Ståle Haugset; Kjekshus, John; Yndestad, Arne & Latini, Roberto [Show all 10 contributors for this article] (2015). Secreted frizzled related protein 3 in chronic heart failure: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA). PLOS ONE. ISSN 1932-6203. 10:e0133970(8). doi: 10.1371/journal.pone.0133970. Full text in Research Archive
• Kjekshus, John (2015). Inflammation: friend and foe. EBioMedicine. ISSN 2352-3964. 2, p. 634–635. doi: 10.1016/j.ebiom.2015.05.029.
• Swerdlow, Daniel I.; Preiss, David; Kuchenbaecker, Karoline B.; Holmes, Michael V.; Engmann, Jorgen E.L. & Shah, Tina [Show all 133 contributors for this article] (2015). HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials. The Lancet. ISSN 0140-6736. 385(9965), p. 351–361. doi: 10.1016/S0140-6736(14)61183-1.
• Abdul-Rahim, Azmil H.; Perez, Ana-Cristina; Fulton, Rachael L.; Jhund, Pardeep S.; Latini, Roberto & Tognoni, Gianni [Show all 13 contributors for this article] (2015). Risk of stroke in chronic heart failure patients without atrial fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza cardiaca-Heart Failure (GISSI-HF) trials. Circulation. ISSN 0009-7322. 131(17), p. 1486–1494. doi: 10.1161/CIRCULATIONAHA.114.013760.
• Kristensen, Søren L; Køber, Lars; Jhund, Pardeep S; Solomon, Scott D; Kjekshus, John & McKelvie, Robert S [Show all 16 contributors for this article] (2015). International geographic variation in event rates in trials of heart failure with preserved and reduced ejection fraction. Circulation. ISSN 0009-7322. 131(1), p. 43–53. doi: 10.1161/CIRCULATIONAHA.114.012284.
• Haver, Vincent G.; Leach, Irene Mateo; Kjekshus, John; Fox, Jayne C.; Wedel, Hans & Wikstrand, John [Show all 11 contributors for this article] (2015). Telomere length and outcomes in ischaemic heart failure: Data from the COntrolled ROsuvastatin multiNAtional Trial in Heart Failure (CORONA). European Journal of Heart Failure. ISSN 1388-9842. 17(3), p. 313–319. doi: 10.1002/ejhf.237.
• Smedsrud, Marit Kristine; Gravning, Jørgen A.; Omland, Torbjørn; Eek, Christian; Mørkrid, Lars & Skulstad, Helge [Show all 10 contributors for this article] (2015). Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain. The International Journal of Cardiovascular Imaging. ISSN 1569-5794. 31(5), p. 967–973. doi: 10.1007/s10554-015-0646-6.
• Feinstein, Matthew J.; Jhund, Pardeep S.; Kang, Joseph; Ning, Hongyan; Maggioni, Aldo Pietro & Wikstrand, John [Show all 10 contributors for this article] (2015). Do statins reduce the risk of myocardial infarction in patients with heart failure? A pooled individual-level reanalysis of CORONA and GISSI-HF. European Journal of Heart Failure. ISSN 1388-9842. 17(4), p. 434–441. doi: 10.1002/ejhf.247.
• Wethal, Torgeir; Røysland, Ragnhild; Omland, Torbjørn & Kjekshus, John (2015). Exercise-induced vasodilation in healthy males: A marker of reduced endothelial function. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 49(3), p. 123–129. doi: 10.3109/14017431.2015.1021708.
• Ueland, Thor; Aukrust, Pål; Nymo, Ståle Haugset; Kjekshus, John; McMurray, John J.V. & Wikstrand, John [Show all 10 contributors for this article] (2015). Predictive Value of Endostatin in Chronic Heart Failure Patients with Poor Kidney Function. Cardiology. ISSN 0008-6312. 130(1), p. 17–22. doi: 10.1159/000368220. Show summary

  OBJECTIVES: Increased circulating endostatin levels have been demonstrated in progressive cardiovascular (CV) and renal disorders. We investigated the predictive value of endostatin in patients with chronic heart failure (HF) and the association between endostatin and renal function. METHODS: The interaction between serum endostatin, estimated glomerular filtration rate (eGFR) and predefined endpoints, including the primary endpoint (CV death, nonfatal myocardial infarction, nonfatal stroke; n = 397), all-cause mortality (n = 410), CV death (n = 335) or the coronary endpoint (n = 317), was evaluated in 1,390 patients >60 years of age with ischemic systolic HF in the Controlled Rosuvastatin Multinational Trial in HF (CORONA) population, who were randomly assigned to 10 mg rosuvastatin or placebo. RESULTS: In the population as a whole, endostatin added no predictive information after full multivariable adjustment including eGFR and N-terminal pro-brain natriuretic peptide. Serum endostatin was strongly correlated with eGFR (r = 0.59, p < 0.001). After full multivariable adjustment, an association between high serum endostatin and increased risk of all-cause mortality and decreased risk of the primary and coronary endpoints was seen in HF patients with impaired and preserved renal function, respectively. CONCLUSIONS: Endostatin added no predictive information regarding the adverse outcome in patients with chronic systolic HF of ischemic etiology. An increased risk of all-cause mortality was seen in patients with decreased renal function.

• Ueland, Thor; Aukrust, Pål; Nymo, Ståle Haugset; Kjekshus, John; McMurray, JJ & Wikstrand, J [Show all 9 contributors for this article] (2015). Novel Extracellular Matrix Biomarkers as Predictors of Adverse Outcome in Chronic Heart Failure: Association Between Biglycan and Response to Statin Therapy in the CORONA Trial. Journal of Cardiac Failure. ISSN 1071-9164. 21(2), p. 153–159. doi: 10.1016/j.cardfail.2014.10.016. Show summary

  BACKGROUND: The extracellular matrix (ECM) plays an important role in left ventricular remodeling and progression of heart failure (HF). Biglycan and mimecan are ECM proteins that are abundantly expressed in cardiac tissue but have not been evaluated as prognostic markers in HF. We investigated their interaction with statin treatment and association with adverse outcome in chronic HF. METHODS AND RESULTS: The association between serum levels of biglycan and mimecan and the primary end point (cardiovascular [CV] death, nonfatal myocardial infarction, nonfatal stroke), all-cause mortality, CV death, the composite of all-cause mortality/hospitalization for worsening of HF, and the coronary end point was evaluated in 1,390 patients >60 years of age with ischemic systolic HF in the Controlled Rosuvastatin Multinational Trial in HF (CORONA) population, randomly assigned to 10 mg rosuvastatin or placebo. Serum biglycan and mimecan added no prognostic information beyond conventional risk factors, including N-terminal pro-B-type natriuretic peptide. However, statin treatment improved all outcomes except CV death in patients with low biglycan levels (ie, lower tertile), even after full multivariable adjustment. CONCLUSIONS: Although circulating levels of mimecan and biglycan were of limited predictive value in patients with chronic HF, circulating biglycan could be a useful marker for targeting statin therapy in patients with HF.

• Kristensen, Søren L.; Jhund, Pardeep S.; Køber, Lars; Preiss, David; Kjekshus, John & McKelvie, Robert S. [Show all 14 contributors for this article] (2015). Comparison of outcomes after hospitalization for worsening heart failure, myocardial infarction, and stroke in patients with heart failure and reduced and preserved ejection fraction. European Journal of Heart Failure. ISSN 1388-9842. 17(2), p. 169–176. doi: 10.1002/ejhf.211.
• Batty, J.A.; Hall, A.S.; White, H.L.; Wikstrand, J.; de Boer, R.A. & van Veldhuisen, D.J. [Show all 11 contributors for this article] (2014). An Investigation of CYP2D6 Genotype and Response to Metoprolol CR/XL During Dose Titration in Patients With Heart Failure: A MERIT-HF Substudy. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 95(3), p. 321–330. doi: 10.1038/clpt.2013.193.
• Haver, Vincent G.; Verweij, Niek; Kjekshus, John; Fox, Jayne C.; Wedel, Hans & Wikstrand, John [Show all 10 contributors for this article] (2014). The impact of coronary artery disease risk loci on ischemic heart failure severity and prognosis: association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA). BMC Medical Genetics. ISSN 1471-2350. 15:140. doi: 10.1186/s12881-014-0140-3.
• Badar, Athar A.; Perez-Moreno, Ana Cristina; Jhund, Pardeep S.; Wong, Chih M.; Hawkins, Nathaniel M. & Cleland, John G F [Show all 14 contributors for this article] (2014). Relationship between angina pectoris and outcomes in patients with heart failure and reduced ejection fraction: an analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). European Heart Journal. ISSN 0195-668X. 35(48), p. 3426–3433. doi: 10.1093/eurheartj/ehu342.
• Kristensen, Søren L.; Køber, Lars; Jhund, Pardeep S; Solomon, Scott D.; Kjekshus, John & McKelvie, Robert S. [Show all 16 contributors for this article] (2014). International Geographic Variation in Event Rates in Trials of Heart Failure With Preserved and Reduced Ejection Fraction. Circulation: Heart Failure. ISSN 1941-3289. doi: 10.1161/CIRCULATIONAHA.114.012284. Show summary

  Background—International geographic differences in outcomes may exist for clinical trials of heart failure and reduced ejection fraction (HF-REF), but there are few data for those with preserved ejection fraction (HF-PEF). Methods and Results—We analyzed outcomes by international geographic region in the Irbesartan in Heart Failure with Preserved systolic function trial (I-Preserve), the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM)-Preserved trial, the CHARM-Alternative and CHARM–Added HF-REF trials, and the Controlled Rosuvastatin Multinational Trial in HF-REF (CORONA). Crude rates of heart failure hospitalization varied by geographic region, and more so for HF-PEF than for HF-REF. Rates in patients with HF-PEF were highest in the United States/Canada (HF hospitalization rate 7.6 per 100 patient-years in I-Preserve; 8.8 in CHARM-Preserved), intermediate in Western Europe (4.8/100 and 4.7/100), and lowest in Eastern Europe/Russia (3.3/100 and 2.8/100). The difference between the United States/Canada versus Eastern Europe/Russia persisted after adjustment for key prognostic variables: adjusted hazard ratios 1.34 (95% confidence interval, 1.01–1.74; P=0.04) in I-Preserve and 1.85 (95% confidence interval, 1.17–2.91; P=0.01) in CHARM-Preserved. In HF-REF, rates of HF hospitalization were slightly lower in Western Europe compared with other regions. For both HF-REF and HF-PEF, there were few regional differences in rates of all-cause or cardiovascular mortality. Conclusions—The differences in event rates observed suggest there is international geographic variation in 1 or more of the definition and diagnosis of HF-PEF, the risk profile of patients enrolled, and the threshold for hospitalization, which has implications for the conduct of future global trials.

• Ketchum, Eric S.; Dickstein, Kenneth; Kjekshus, John; Pitt, Bertram; Wong, Meagan F. & Linker, David T. [Show all 7 contributors for this article] (2014). The Seattle Post Myocardial Infarction Model (SPIM): prediction of mortality after acute myocardial infarction with left ventricular dysfunction. European Heart Journal: Acute Cardiovascular Care. ISSN 2048-8726. 3(1), p. 46–55. doi: 10.1177/2048872613502283.
• Perez, Ana-Cristina; Jhund, Pardeep S.; Stott, David J.; Gullestad, Lars; Cleland, John G.F. & van Veldhuisen, Dirk J. [Show all 9 contributors for this article] (2014). Thyroid-Stimulating Hormone and Clinical Outcomes: The CORONA Trial (Controlled Rosuvastatin Multinational Study in Heart Failure). JACC. Heart failure. ISSN 2213-1779. 2(1), p. 35–40. doi: 10.1016/j.jchf.2013.07.008.
• Perez-Moreno, Ana Cristina; Jhund, Pardeep S.; Macdonald, Michael R.; Petrie, Mark C.; Cleland, John G.F. & Böhm, Michael [Show all 12 contributors for this article] (2014). Fatigue as a predictor of outcome in patients with heart failure. Analysis of CORONA (Controlled rosuvastatin multinational trial in heart failure). JACC. Heart failure. ISSN 2213-1779. 2(2), p. 187–197. doi: 10.1016/j.jchf.2014.01.001.
• Rogers, Jennifer K.; Jhund, Pardeep S.; Perez, Ana-Cristina; Böhm, Michael; Cleland, John G. & Gullestad, Lars [Show all 12 contributors for this article] (2014). Effect of rosuvastatin on repeat heart failure hospitalizations: The CORONA trial (controlled rosuvastatin multinational trial in heart failure). JACC. Heart failure. ISSN 2213-1779. 2(3), p. 289–297. doi: 10.1016/j.jchf.2013.12.007.
• Gravning, Jørgen A.; Askevold, Erik Tandberg; Nymo, Ståle Haugset; Ueland, Thor; Wikstrand, John & McMurray, John J.V. [Show all 9 contributors for this article] (2014). Prognostic effect of high-sensitive troponin t assessment in elderly patients with chronic heart failure results from the CORONA Trial. Circulation: Heart Failure. ISSN 1941-3289. 7(1), p. 96–103. doi: 10.1161/CIRCHEARTFAILURE.113.000450.
• Wethal, Torgeir; Nedregaard, Bård; Andersen, Rune; Fosså, Alexander; Lund, May-Brith & Gunther, Anne [Show all 9 contributors for this article] (2014). Atherosclerotic lesions in lymphoma survivors treated with radiotherapy. Radiotherapy and Oncology. ISSN 0167-8140. 110(3), p. 448–454. doi: 10.1016/j.radonc.2013.10.029.
• Inglis, Sally C.; Bebchuk, Judith; Al-Suhaim, Sultan A.; Case, Jessica; Pfeffer, Marc A. & Solomon, Scott D. [Show all 14 contributors for this article] (2013). Peripheral artery disease and outcomes after myocardial infarction: An individual-patient meta-analysis of 28,771 patients in CAPRICORN, EPEHESUS, OPTIMAAL and VALIANT. International Journal of Cardiology. ISSN 0167-5273. 168(2), p. 1094–1101. doi: 10.1016/j.ijcard.2012.11.033.
• Ueland, Thor; Nymo, Ståle Haugset; Latini, Roberto; McMurray, John J.V.; Kjekshus, John & Yndestad, Arne [Show all 12 contributors for this article] (2013). CCL21 is associated with fatal outcomes in chronic heart failure: data from CORONA and GISSI-HF trials. European Journal of Heart Failure. ISSN 1388-9842. 15(7), p. 747–755. doi: 10.1093/eurjhf/hft031.
• Gravning, Jørgen A.; Smedsrud, Marit Kristine; Omland, Torbjørn; Eek, Christian; Skulstad, Helge & Aaberge, Lars [Show all 10 contributors for this article] (2013). Sensitive troponin assays and N-terminal pro-B-type natriuretic peptide in acute coronary syndrome: Prediction of significant coronary lesions and long-term prognosis. American Heart Journal. ISSN 0002-8703. 165(5), p. 716–724. doi: 10.1016/j.ahj.2013.02.008.
• Jaffe, Leeror M.; Kjekshus, John & Gottlieb, Stephen S. (2013). Importance and management of chronic sleep apnoea in cardiology. European Heart Journal. ISSN 0195-668X. 34(11), p. 809–815. doi: 10.1093/eurheartj/ehs046.
• Gullestad, Lars; Ueland, Thor; Kjekshus, John; Nymo, Ståle Haugset; Hulthe, Johannes & Muntendam, Pieter [Show all 9 contributors for this article] (2012). The predictive value of galectin-3 for mortality and cardiovascular events in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). American Heart Journal. ISSN 0002-8703. 164(6), p. 878–883. doi: 10.1016/j.ahj.2012.08.021.
• Gullestad, Lars; Ueland, Thor; Kjekshus, John; Nymo, Ståle Haugset; Hulthe, Johannes & Muntendam, Pieter [Show all 14 contributors for this article] (2012). Galectin-3 predicts response to statin therapy in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). European Heart Journal. ISSN 0195-668X. 33(18), p. 2290–2296. doi: 10.1093/eurheartj/ehs077.
• Kåsin, Jan Ivar; Kjellevand, Tor Ole; Kjekshus, John; Nesheim, Geir B. & Wagstaff, Anthony Sverre (2012). CT Examination of the Pericardium and Lungs in Helicopter Pilots Exposed to Vibration and Noise. Aviation, Space and Environmental Medicine. ISSN 0095-6562. 83(9), p. 858–864. doi: 10.3357/ASEM.3209.2012.
• Preiss, David; Tikkanen, Matti J.; Welsh, Paul; Ford, Ian; Lovato, Laura C. & Elam, Marshall B. [Show all 18 contributors for this article] (2012). Lipid-modifying therapies and risk of pancreatitis : a meta-analysis. Journal of the American Medical Association (JAMA). ISSN 0098-7484. 308(8), p. 804–811. doi: 10.1001/jama.2012.8439.
• Yndestad, Arne; Finsen, Alexandra; Ueland, Thor; Husberg, Cathrine; Dahl, Christen Peder & Øie, Erik [Show all 19 contributors for this article] (2012). The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure. PLOS ONE. ISSN 1932-6203. 7(3). doi: 10.1371/journal.pone.0033038.
• Nymo, Ståle Haugset; Ueland, Thor; Askevold, Erik Tandberg; Flo, Trude Helen; Kjekshus, John & Hulthe, Johannes [Show all 12 contributors for this article] (2012). The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA. Journal of Internal Medicine. ISSN 0954-6820. 271(5), p. 436–443. doi: 10.1111/j.1365-2796.2011.02503.x.
• Broch, Kaspar; Ueland, Thor; Nymo, Ståle Haugset; Kjekshus, John; Hulthe, Johannes & Muntendam, Pieter [Show all 11 contributors for this article] (2012). Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology. European Journal of Heart Failure. ISSN 1388-9842. 14(3), p. 268–277. doi: 10.1093/eurjhf/hfs006.
• Askevold, Erik Tandberg; Nymo, Ståle Haugset; Ueland, Thor; Gravning, Jørgen A.; Wergeland, Ragnhild & Kjekshus, John [Show all 11 contributors for this article] (2012). Soluble Glycoprotein 130 predicts Fatal Outcomes in Chronic Heart Failure: Analysis From the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). Circulation: Heart Failure. ISSN 1941-3289. p. 91–98. doi: 10.1161/CIRCHEARTFAILURE.112.972653.
• Ueland, Thor; Dahl, Christen Peder; Kjekshus, John; Hulthe, Johannes; Böhm, Michael & Mach, Francois [Show all 11 contributors for this article] (2011). Osteoprotegerin Predicts Progression of Chronic Heart Failure: Results From CORONA. Circulation: Heart Failure. ISSN 1941-3289. 4(2), p. 145–152. doi: 10.1161/CIRCHEARTFAILURE.110.957332.
• Sattar, Naveed; Preiss, David; Murray, Heather M.; Welsh, Paul; Buckley, Brendan M. & de Craen, Anton J.M. [Show all 33 contributors for this article] (2010). Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. The Lancet. ISSN 0140-6736. 375(9716), p. 735–742. doi: 10.1016/S0140-6736(09)61965-6.
• Wethal, Torgeir; Haugnes, Hege Sagstuen; Kjekshus, John; Småstuen, Milada C; Ueland, Thor & Aukrust, Pål [Show all 7 contributors for this article] (2010). C-reactive protein; a potential marker of second cancer and cardiovascular disease in testicular cancer survivors? International Journal of Cancer. ISSN 0020-7136. 46, p. 3425–3433. doi: 10.1016/j.ejca.2010.08.004.
• Kim, M; Yang, D.; Kida, K; Molotkova, N; Yeo, SJ & Varki, N [Show all 14 contributors for this article] (2010). Effects of ACE2 Inhibition in the Post-Myocardial Infarction Heart. Journal of Cardiac Failure. ISSN 1071-9164. 16(9), p. 777–785. doi: 10.1016/j.cardfail.2010.04.002.
• Andersen, Rune; Wethal, Torgeir; Günther, Anne; Fosså, Alexander; Edvardsen, Thor & Fosså, Sophie Dorothea [Show all 7 contributors for this article] (2010). Relation of Coronary Artery Calcium Score to Premature Coronary Artery Disease in Survivors &gt; 15 Years of Hodgkin's Lymphoma. American Journal of Cardiology. ISSN 0002-9149. 105(2), p. 149–152. doi: 10.1016/j.amjcard.2009.09.005.
• Inglis, Sally C.; McMurray, JJV; Bohm, M; Schaufelberger, M; Van Veldhuisen, D J & Lindberg, M [Show all 12 contributors for this article] (2010). Intermittent claudication as a predictor of outcome in patients with ischaemic systolic heart failure: analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure trial (CORONA). European Journal of Heart Failure. ISSN 1388-9842. 12(7), p. 698–705. doi: 10.1093/eurjhf/hfq070.
• Lorgelly, PK; Briggs, AH; Wedel, H; Dunselman, P; Hjalmarson, A & Kjekshus, John [Show all 13 contributors for this article] (2010). An economic evaluation of rosuvastatin treatment in systolic heart failure: evidence from the CORONA trial. European Journal of Heart Failure. ISSN 1388-9842. 12(1), p. 66–74. doi: 10.1093/eurjhf/hfp172.
• McMurray, John J.V.; Dunselman, Peter; Wedel, Hans; Cleland, John G.F.; Lindberg, Magnus & Hjalmarson, Åke [Show all 15 contributors for this article] (2010). Coenzyme Q(10), Rosuvastatin, and Clinical Outcomes in Heart Failure A Pre-Specified Substudy of CORONA (Controlled Rosuvastatin Multinational Study in Heart Failure). Journal of the American College of Cardiology. ISSN 0735-1097. 56(15), p. 1196–1204. doi: 10.1016/j.jacc.2010.02.075.
• Kjekshus, John (2009). Statins and heart failure. In Tonkin, AM (Eds.), Therapeutic Strategies in Lipid Disorders. Clinical Publishing. ISSN 9781846920349. p. 143–154.
• Ghali, JK; Wikstrand, John; Van Veldhuisen, D J; Fagerberg, Bjørn; Goldstein, Sidney & Hjalmarson, A [Show all 12 contributors for this article] (2009). The Influence of Renal Function on Clinical Outcome and Response to beta-Blockade in Systolic Heart Failure: Insights From Metoprolol CR/XL Randomized Intervention Trial in Chronic HF (MERIT-HF). Journal of Cardiac Failure. ISSN 1071-9164. 15(4), p. 310–318. doi: 10.1016/j.cardfail.2008.11.003.
• Wedel, H; McMurray, JJ; Lindberg, Magnus; Wikstrand, John; Cleland, JG & Cornel, JH [Show all 13 contributors for this article] (2009). Predictors of fatal and non-fatal outcomes in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): incremental value of apolipoprotein A-1, high-sensitivity C-reactive peptide and N-terminal pro B-type natriuretic peptide. European Journal of Heart Failure. ISSN 1388-9842. 11, p. 281–291. doi: 10.1093/eurjhf/hfn046.
• Yndestad, A; Landrø, Linn; Ueland, Thor; Dahl, CP; Flo, Trude Helen & Vinge, Leif Erik [Show all 15 contributors for this article] (2009). Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. European Heart Journal. ISSN 0195-668X. 30(10), p. 1229–1236. doi: 10.1093/eurheartj/ehp088. Show summary

  Aims: Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2) is a glycoprotein with bacteriostatic properties. Growing evidence suggests that NGAL may also be involved in cell survival, inflammation, and matrix degradation. We therefore aimed to investigate the role of NGAL in heart failure (HF). Methods and results: Our main findings were (i) patients with acute post-myocardial infarction (MI) HF (n = 236) and chronic HF (n = 150) had elevated serum levels of NGAL (determined by enzyme immunoassay), significantly correlated with clinical and neurohormonal deterioration, (ii) in patients with HF following acute MI, elevated NGAL levels of at baseline were associated with adverse outcomes (median of 27 months follow-up), (iii) in a rat model of post-MI HF, NGAL/lipocalin-2 gene expression was increased in the non-ischaemic part of the left ventricle primarily located to cardiomyocytes, (iv) strong NGAL immunostaining was found in cardiomyocytes within the failing myocardium both in experimental and clinical HF, (v) interleukin-1β and agonists for toll-like receptors 2 and 4, representing components of the innate immune system, were potent inducers of NGAL/lipocalin-2 in isolated neonatal cardiomyocytes. Conclusion: Our demonstration of enhanced systemic and myocardial NGAL expression in clinical and experimental HF further support a role for innate immune responses in the pathogenesis of HF.

• Huskey, Janna; Lindenfeld, Johann; Cook, Thomas; Targher, Giovanni; Kendrick, Jessica & Kjekshus, John [Show all 8 contributors for this article] (2009). Effect of simvastatin on kidney function loss in patients with coronary heart disease: Findings from the Scandinavian Simvastatin Survival Study (4S). Atherosclerosis. ISSN 0021-9150. 205(1), p. 202–206. doi: 10.1016/j.atherosclerosis.2008.11.010.
• Cleland, John G.F.; McMurray, John J.V.; Kjekshus, John; Cornel, Jan H.; Dunselman, Peter & Fonseca, Candida [Show all 14 contributors for this article] (2009). Plasma Concentration of Amino-Terminal Pro-Brain Natriuretic Peptide in Chronic Heart Failure: Prediction of Cardiovascular Events and Interaction With the Effects of Rosuvastatin A Report From CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure). Journal of the American College of Cardiology. ISSN 0735-1097. 54(20), p. 1850–1859. doi: 10.1016/j.jacc.2009.06.041.
• McMurray, John J.V.; Kjekshus, John; Gullestad, Lars; Dunselman, Peter; Hjalmarson, Åke & Wedel, Hans [Show all 16 contributors for this article] (2009). Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the controlled rosuvastatin multinational trial in heart failure (CORONA). A retrospective analysis. Circulation. ISSN 0009-7322. 120(22), p. 2188–U51. doi: 10.1161/CIRCULATIONAHA.109.849117.
• Kasin, JI; Kjekshus, John; Aukrust, Pål; Mollnes, Tom Eirik & Wagstaff, A. S. (2009). A helicopter flight does not induce significant changes in systemic biomarker profiles. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 69(4), p. 462–474. doi: 10.1080/00365510902745360.
• Kjekshus, John; Torp-Pedersen, C; Gullestad, Lars; Kober, L; Edvardsen, Thor & Olsen, IC [Show all 11 contributors for this article] (2009). Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. European Journal of Heart Failure. ISSN 1388-9842. 11(8), p. 771–778. doi: 10.1093/eurjhf/hfp087.
• Wethal, Torgeir; Lund, May Brit; Edvardsen, Thor; Fosså, Sophie Dorothea; Pripp, AH & Holte, Harald [Show all 8 contributors for this article] (2009). Valvular dysfunction and left ventricular changes in Hodgkin's lymphoma survivors. A longitudinal study. British Journal of Cancer. ISSN 0007-0920. 101(4), p. 575–581. doi: 10.1038/sj.bjc.6605191.
• Anker, Stefan D.; Voors, Adriaan A.; Okonko, Darlington; Clark, Andrew L.; James, Margaret K. & von Haehling, Stephan [Show all 9 contributors for this article] (2009). Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: data from the OPTIMAAL trial. European Heart Journal. ISSN 0195-668X. 30(11), p. 1331–1339. doi: 10.1093/eurheartj/ehp116.
• Gravning, J; Ueland, T; Mørkrid, Lars; Endresen, Knut; Aaberge, Lars & Kjekshus, John (2008). Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris. Scandinavian Cardiovascular Journal. ISSN 1401-7431. 42, p. 214–221. doi: 10.1080/14017430801932824.
• Gullestad, Lars & Kjekshus, John (2008). Hjertemedisinsk forskning - et lotteri? Dagens medisin. ISSN 1501-4290. 3.
• Huskey, J; Lindenfeld, J; Cook, T; Targher, G; Kendrick, J & Kjekshus, John [Show all 8 contributors for this article] (2008). Effect of simvastatin on kidney function loss in patients with coronary heart disease Findings from the Scandinavian Simvastatin Survival Study (4S). Atherosclerosis. ISSN 0021-9150.
• Kjekshus, John; Arnesen, Harald & Gullestad, Lars (2007). Klinisk forskning: medikamentell behandling. In Forfang, Kolbjørn & Rasmussen, Knut (Ed.), Det norske hjerte. Norsk hjertemedisins historie. Universitetsforlaget. ISSN 978-82-15-00891-2. p. 293–310.
• Chonchol, M; Cook, T; Kjekshus, John; Pedersen, TR & Lindenfeld, J (2007). Simvastatin for secondary prevention of all-cause mortality and major coronary events in patients with mild chronic renal insufficiency. American Journal of Kidney Diseases. ISSN 0272-6386. 49, p. 373–382. doi: 10.1053/j.ajkd.2006.11.043.
• Wethal, Torgeir; Kjekshus, John; Røislien, Jo; Ueland, Thor; Andreassen, Arne K. & Wergeland, Ragnhild [Show all 8 contributors for this article] (2007). Treatment-related differences in cardiovascular risk factors in long-term survivors of testicular cancer. Journal of cancer survivorship. ISSN 1932-2259. 1, p. 8–16.
• Kjekshus, John; Apetrei, E; Barrios, V; Bohm, M; Cleland, JG & Cornel, JH [Show all 28 contributors for this article] (2007). Rosuvastatin in older patients with systolic heart failure. New England Journal of Medicine. ISSN 0028-4793. 357, p. 2248–2261. doi: 10.1056/NEJMoa0706201.
• Damås, Jan Kristian; Smith, Camilla; Øie, Erik; Fevang, Børre; Halvorsen, Bente & Waehre, Torgun [Show all 19 contributors for this article] (2007). Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis - Possible pathogenic role in plaque destabilization. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 27, p. 614–620. doi: 10.1161/01.ATV.0000255581.38523.7c.
• Dickstein, Kenneth; Gleim, Gilbert W.; Snappin, Steven; Snapinn, Steven M.; James, Margaret K. & Kjekshus, John (2006). The impact of morbid events on survival following hospitalization for complicated myocardial infarction. European Journal of Heart Failure. ISSN 1388-9842. 8(1), p. 74–80. doi: 10.1016/j.ejheart.2005.04.010.
• Waaler, Bjarne; Hisdal, Jonny; Ihlen, Halfdan & Kjekshus, John (2006). Mechanisms behind the postprandial increase in cardiac output: a clue obtained from transplanted hearts. European Journal of Applied Physiology. ISSN 1439-6319. 97, p. 516–520.
• Gravning, Jørgen A.; Vege, Åshild & Kjekshus, John (2006). Plutselig uventet dødsfall etter perkutan koronar intervensjon. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 24(126), p. 2111–2113.
• Holm, Torbjørn; Ueland, Thor; Halvorsen, Bente ; Hognestad, Aina; Holm, A.G. & Wergeland, Ragnhild [Show all 9 contributors for this article] (2006). A protective anti-inflammatory phenotype in high-risk individuals who do not develop coronary artery disease. JACC. ISSN 1021-8009. 47(5), p. 1085–1086.
• Kennedy, L M; Anker, S D; Kjekshus, John; Cook, TJ & Willenheimer, R (2006). Impact of neurohormonal blockade on association between body mass index and mortality. International Journal of Cardiology. ISSN 0167-5273.
• Estensen, Mette Elise; Hognestad, Aina; Syversen, Unni; Squire, Iain; Ng, Leong & Kjekshus, John [Show all 8 contributors for this article] (2006). Prognostic value of plasma chromogranin A levels in patients with complicated myocardial infarction. American Heart Journal. ISSN 0002-8703. 152(5), p. 927e1–927e6.
• Kjekshus, John (2006). The effect of heart rate reduction on survival in heart failure. Medicographia. ISSN 0243-3397. 28, p. 238–244.

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• Abdul-Rahim, Azmil H.; Perez, Ana-Cristina; Fulton, Rachael L.; Jhund, Pardeep S.; Latini, Roberto & Tognoni, Gianni [Show all 13 contributors for this article] (2015). Response to Letter Regarding Article, "risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials". Circulation. ISSN 0009-7322. 132(22). doi: 10.1161/CIRCULATIONAHA.115.018395.
• Kjekshus, John (2015). Are statins failing in heart failure? European Heart Journal. ISSN 0195-668X. 36(24), p. 1502–1504. doi: 10.1093/eurheartj/ehv133.
• Dobre, D.; Zannad, F.; Kjekshus, John & Dickstein, Kenneth (2013). The association between heart rate, pulse pressure and clinical outcomes in 16503 patients with myocardial infarction complicated by signs of heart failure or left ventricular dysfunction. European Heart Journal. ISSN 0195-668X. 34, p. 349–349.
• Dahl, Christen Peder; Aukrust, Pål; Nymo, Ståle Haugset; Kjekshus, John; Cleland, John G.F. & McMurray, John J. V. [Show all 9 contributors for this article] (2013). Prognostic value of CXCL16 in patients with left ventricular systolic dysfunction and heart failure. International Journal of Cardiology. ISSN 0167-5273. 168(4), p. 4427–4429. doi: 10.1016/j.ijcard.2013.05.008.
• Perez, A; Jhund, Pardeep; Preiss, David; Kjekshus, John & McMurray, John J.V. (2013). Effect of Rosuvastatin on Fatigue in Patients With Heart Failure. Journal of the American College of Cardiology. ISSN 0735-1097. 61(10), p. 1121–1122. doi: 10.1016/j.jacc.2012.12.004.
• Gravning, Jørgen A.; Askevold, Erik Tandberg; Nymo, Ståle Haugset; Ueland, Thor; Wergeland, Ragnhild & Wikstrand, J [Show all 9 contributors for this article] (2012). Prognostic impact of high-sensitive troponin T assessment in chronic heart failure and interaction with statin therapy. Results from CORONA. European Heart Journal. ISSN 0195-668X. 33, p. 644–645.
• Wethal, Torgeir; Haugnes, Hege Sagstuen; Kjekshus, John; Småstuen, Milada Cvancarova; Ueland, Thor & Aukrust, Pål [Show all 7 contributors for this article] (2010). C-reactive protein; a potential marker of second cancer and cardiovascular disease in testicular cancer survivors? European Journal of Cancer. ISSN 0959-8049. 46(18), p. 3425–3433. doi: 10.1016/j.ejca.2010.08.004.
• Wethal, Torgeir; Haugnes, Hege Sagstuen; Kjekshus, John; Småstuen, Milada; Ueland, Thor & Aukrust, Pål [Show all 7 contributors for this article] (2010). C-reactive protein; a potential marker of second cancer and cardiovascular disease in testicular cancer survivors? European Journal of Cancer. ISSN 0959-8049. 8(5), p. 152–153.
• Kjekshus, John (2009). Is there a heart rate paradox - demystification of the myths? Journal of Internal Medicine. ISSN 0954-6820. 266(3), p. 242–247. doi: 10.1111/j.1365-2796.2009.02143.x.
• Inglis, S; McMurray, J; Wedel, H; Dunselman, P; Kjekshus, John & Hjalmarson, A [Show all 8 contributors for this article] (2009). Intermittent claudication as a new predictor of outcome in heart failure: evidence from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
• Kjekshus, John (2008). Risk associated with statin treatment. Journal of the American College of Cardiology. ISSN 0735-1097. 51, p. 91–91. doi: 10.1016/j.jacc.2007.08.056.
• Kjekshus, John (2008). What are the effects of patient age and blood pressure on the cholesterol-related risk of vascular mortality? Nature Clinical Practice Cardiovascular Medicine. ISSN 1743-4297. 5, p. 310–311. doi: 10.1038/ncpcardio1209.
• Gravning, Jørgen Amundsen & Kjekshus, John (2008). The perfect biomarker in acute coronary syndrome: a challenge for diagnosis, prognosis, and treatment. European Heart Journal. ISSN 0195-668X. 29(23), p. 2827–2828. doi: 10.1093/eurheartj/ehn489.
• Kjekshus, John (2008). Risk associated with statin treatment. Journal of the American College of Cardiology. ISSN 0735-1097. 51.
• Kjekshus, John (2008). Practice point. What are the effects of patient age and blood pressure on the cholesterol-related risk of vascular mortality? Nature Clinical Practice Cardiovascular Medicine. ISSN 1743-4297. 5(6), p. 310–311. doi: 10.1038/ncpcardio1209.
• Kjekshus, John; Edvardsen, Thor; Gullestad, Lars; Koeber, L; Osnes, Jan-Bjørn & Qvigstad, Erik [Show all 10 contributors for this article] (2008). The effect of Piboserod a 5-HT4-receptor antagonist on left ventricular function in patients with symptomatic heart failure.
• Wethal, Torgeir; Lund, May Brit; Fosså, Sophie Dorothea; Kjekshus, John; Edvardsen, Thor & Pripp, AH [Show all 8 contributors for this article] (2008). Late onset valvular and myocardial dysfunction in Hodgkin lymphoma survivors.
• Kjekshus, John (2007). Prescription of beta-blockers in patients with advanced heart failure and preserved left ventricular ejection fraction. Clinical implications and survival. European Journal of Heart Failure. ISSN 1388-9842. 9, p. 962–963.
• Kjekshus, John (2007). Untitled. European Journal of Heart Failure. ISSN 1388-9842. 9.

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