Kirsten Muri Boberg

• Gjersvik, Petter; Falk, Ragnhild Sørum; Roscher, Ingrid; Rizvi, Syed Mohammad Husain; Mjøen, Geir & Gude, Einar [Show all 10 contributors for this article] (2023). Rates of Second Tumor, Metastasis, and Death from Cutaneous Squamous Cell Carcinoma in Patients with and Without Transplant-Associated Immunosuppression. JAMA dermatology. ISSN 2168-6068. 159(9), p. 923–929. doi: 10.1001/jamadermatol.2023.2029.
• Hole, Mikal Jacob; Jørgensen, Kristin Kaasen; Holm, Kristian; Braadland, Peder Rustøen; Meyer-Myklestad, Malin Holm & Medhus, Asle Wilhelm [Show all 13 contributors for this article] (2022). A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.32773. Full text in Research Archive
• Vedeld, Hege Marie; Grimsrud, Marit Mæhle; Andresen, Kim; Pharo, Heidi Dietrichson; von Seth, Erik & Karlsen, Tom Hemming [Show all 15 contributors for this article] (2021). Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile. Hepatology. ISSN 0270-9139. doi: 10.1002/hep.32125. Full text in Research Archive
• Ponsioen, Cyriel Y.; Assis, David N.; Boberg, Kirsten Muri; Bowlus, Christopher; Deneau, Mark & Thorburn, Douglas [Show all 11 contributors for this article] (2021). Defining Primary Sclerosing Cholangitis: Results From an International Primary Sclerosing Cholangitis Study Group Consensus Process. Gastroenterology. ISSN 0016-5085. 161(6), p. 1764–1775. doi: 10.1053/j.gastro.2021.07.046. Full text in Research Archive
• Bossen, Lars; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund; Färkkilä, Martti; Rosenberg, William & Møller, Holger J. [Show all 9 contributors for this article] (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. Clinical and Translational Gastroenterology. ISSN 2155-384X. 12(3), p. e00315–e00315. doi: 10.14309/ctg.0000000000000315. Full text in Research Archive
• Vesterhus, Mette; Nielsen, Mette Juul; Hov, Johannes Roksund; Saffioti, Francesca; Manon-Jensen, Tina & Leeming, Diana Julie [Show all 12 contributors for this article] (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. JHEP Reports. 3(1), p. 1–11. doi: 10.1016/j.jhepr.2020.100178. Full text in Research Archive
• Goeppert, Benjamin; Folseraas, Trine; Roessler, Stephanie; Kloor, Matthias; Volckmar, Anna-Lena & Endris, Volker [Show all 36 contributors for this article] (2020). Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals therapeutic opportunities. Hepatology. ISSN 0270-9139. 72(4), p. 1253–1266. doi: 10.1002/hep.31110. Full text in Research Archive
• Saffioti, Francesca; Roccarina, Davide; Vesterhus, Mette; Hov, Johannes Espolin Roksund; Rosenberg, William & Pinzani, Massimo [Show all 9 contributors for this article] (2019). Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis. European Journal of Clinical Investigation. ISSN 0014-2972. 49(5). doi: 10.1111/eci.13088.
• Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin; Boberg, Kirsten Muri; Elferink, Ronald P. Oude & Karlsen, Tom Hemming [Show all 9 contributors for this article] (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-44762-7. Full text in Research Archive
• Nielsen, MJ; Thorburn, Douglas; Leeming, DJ; Hov, Johannes Espolin Roksund; Nygård, Ståle & Moum, Bjørn [Show all 15 contributors for this article] (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 48, p. 179–189. doi: 10.1111/apt.14806.
• Åberg, Fredrik; Isoniemi, Helena; Pukkala, Eero; Jalanko, Hannu; Rasmussen, Allan & Storm, Hans H. [Show all 17 contributors for this article] (2018). Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries. Liver transplantation. ISSN 1527-6465. 24(9), p. 1252–1259. doi: 10.1002/lt.25305. Full text in Research Archive
• Lindström, Lina; Jørgensen, Kristin Kaasen; Boberg, Kirsten Muri; Castedal, Maria; Rasmussen, Allan & Rostved, Andreas Arendtsen [Show all 9 contributors for this article] (2018). Risk factors and prognosis for recurrent primary sclerosing cholangitis after liver transplantation: a Nordic Multicentre Study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 53(3), p. 297–304. doi: 10.1080/00365521.2017.1421705.
• Nordin, A; Åberg, F; Pukkala, E; Pedersen, CR; Storm, HH & Rasmussen, A. [Show all 15 contributors for this article] (2018). Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades. American Journal of Transplantation. ISSN 1600-6135. 18(4), p. 952–963. doi: 10.1111/ajt.14507.
• Rizvi, Syed Mohammad Husain; Aagnes, Bjarte; Holdaas, Hallvard; Gude, Einar; Boberg, Kirsten Muri & Bjørtuft, Øystein [Show all 10 contributors for this article] (2017). Long-term Change in the Risk of Skin Cancer After Organ Transplantation: A Population-Based Nationwide Cohort Study. JAMA dermatology. ISSN 2168-6068. 153(12), p. 1270–1277. doi: 10.1001/jamadermatol.2017.2984. Full text in Research Archive
• Alberts, R; de Vries, EMG; Goode, EC; Jiang, Xiaojun; Sampaziotis, Fotios & Rombouts, K [Show all 50 contributors for this article] (2017). Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis. Gut. ISSN 0017-5749. 67(8), p. 1517–1524. doi: 10.1136/gutjnl-2016-313598.
• Weismüller, Tobias J.; Trivedi, Palak J.; Bergquist, Annika; Imam, Mohamad; Lenzen, Henrike & Ponsioen, Cyriel Y. [Show all 59 contributors for this article] (2017). Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis. Gastroenterology. ISSN 0016-5085. 152(8), p. 1975–1984.e8. doi: 10.1053/j.gastro.2017.02.038.
• de Vries, Elisabeth M.G.; Färkkilä, Martti; Milkiewicz, Piotr; Hov, Johannes Espolin Roksund; Eksteen, Bertus & Thorburn, Douglas [Show all 21 contributors for this article] (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. Liver international (Print). ISSN 1478-3223. 37(10), p. 1554–1561. doi: 10.1111/liv.13402. Full text in Research Archive
• Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund; Nygård, Ståle; Schrumpf, Erik & Melum, Espen [Show all 23 contributors for this article] (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. Journal of Hepatology. ISSN 0168-8278. 66(6), p. 1214–1222. doi: 10.1016/j.jhep.2017.01.019.
• Hov, Johannes Espolin Roksund; Boberg, Kirsten Muri; Taraldsrud, Eli; Vesterhus, Mette; Boyadzhieva, Maria & Solberg, Inger Camilla [Show all 11 contributors for this article] (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. Liver international (Print). ISSN 1478-3223. 37(3), p. 458–465. doi: 10.1111/liv.13238.
• Henriksen, Eva Kristine Klemsdal; Jørgensen, Kristin Kaasen; Kaveh, Fatemeh; Holm, Kristian; Hamm, David & Olweus, Johanna [Show all 14 contributors for this article] (2017). Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease. Journal of Hepatology. ISSN 0168-8278. 66(1), p. 116–122. doi: 10.1016/j.jhep.2016.09.002.
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M. & Boberg, Kirsten Muri [Show all 10 contributors for this article] (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. United European Gastroenterology Journal (UEG Journal). ISSN 2050-6406. 5(4), p. 532–541. doi: 10.1177/2050640616663453.
• Zenouzi, Roman; Weismüller, Tobias J; Jørgensen, Kristin Kaasen; Bubenheim, Michael; Lenzen, Henrike & Hübener, Peter [Show all 19 contributors for this article] (2016). No Evidence That Azathioprine Increases Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis. Clinical Gastroenterology and Hepatology. ISSN 1542-3565. 14(12), p. 1806–1812. doi: 10.1016/j.cgh.2016.07.032.
• Bernuzzi, F.; Marabita, F.; Lleo, A.; Carbone, M.; Mirolo, M. & Marzioni, M. [Show all 18 contributors for this article] (2016). Serum microRNAs as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma. Clinical and Experimental Immunology. ISSN 0009-9104. 185(1), p. 61–71. doi: 10.1111/cei.12776.
• Ji, Sun-Gou; Juran, Brian D.; Mucha, Sören; Folseraas, Trine; Jostins, Luke & Melum, Espen [Show all 39 contributors for this article] (2016). Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nature Genetics. ISSN 1061-4036. 49(20), p. 269–273. doi: 10.1038/ng.3745.
• Banales, Jesus M.; Cardinale, Vincenzo; Carpino, Guido; Marzioni, Marco; Andersen, Jesper B. & Invernizzi, Pietro [Show all 24 contributors for this article] (2016). Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA). Nature reviews: Gastroenterology & hepatology. ISSN 1759-5045. 13(5), p. 261–280. doi: 10.1038/nrgastro.2016.51.
• Harbord, M; Annese, V; Vavricka, SR; Allez, M.; Barreiro-de Acosta, M & Boberg, Kirsten Muri [Show all 21 contributors for this article] (2016). The first European evidence-based consensus on extra-intestinal manifestations in inflammatory bowel disease. Journal of Crohn's and Colitis. ISSN 1873-9946. 10(3), p. 239–254. doi: 10.1093/ecco-jcc/jjv213.
• Folseraas, Trine & Boberg, Kirsten Muri (2016). Cancer Risk and Surveillance in Primary Sclerosing Cholangitis. Clinics in Liver Disease. ISSN 1089-3261. 20(1), p. 79–98. doi: 10.1016/j.cld.2015.08.014.
• Andersen, Ina Marie; Fosby, Bjarte; Boberg, Kirsten Muri; Clausen, Ole Petter Fraas; Jebsen, Peter Wilhelm & Melum, Espen [Show all 10 contributors for this article] (2015). Indications and Outcomes in Liver Transplantation in Patients with Primary Sclerosing Cholangitis in Norway. Transplantation direct. ISSN 2373-8731. 1(9). doi: 10.1097/TXD.0000000000000548.
• Vesterhus, Mette; Hov, Johannes Espolin Roksund; Holm, Anders; Schrumpf, Erik; Nygård, Ståle & Godang, Kristin [Show all 25 contributors for this article] (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. Hepatology. ISSN 0270-9139. 62(1), p. 188–197. doi: 10.1002/hep.27825.
• Thorsen, Trygve; Dahlgren, Ulrika S.; Aandahl, Einar Martin; Grzyb, Krzysztof; Karlsen, Tom Hemming & Boberg, Kirsten Muri [Show all 10 contributors for this article] (2015). Liver transplantation with deceased ABO-incompatible donors is life-saving but associated with increased risk of rejection and post-transplant complications. Transplant International. ISSN 0934-0874. 28(7), p. 800–812. doi: 10.1111/tri.12552.
• Fosby, Bjarte; Melum, Espen; Bjøro, Kristian; Bennet, William; Rasmussen, Allan & Andersen, Ina Riise [Show all 30 contributors for this article] (2015). Liver transplantation in the Nordic countries-An intention to treat and post-transplant analysis from the Nordic Liver Transplant Registry 1982-2013. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 50(6), p. 797–808. doi: 10.3109/00365521.2015.1036359.
• Andresen, Kim; Boberg, Kirsten Muri; Vedeld, Hege Marie; Honne, Hilde; Jebsen, Peter Wilhelm & Hektoen, Merete [Show all 16 contributors for this article] (2015). Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma. Hepatology. ISSN 0270-9139. 61(5), p. 1651–1659. doi: 10.1002/hep.27707.
• Åberg, Fredrik; Gissler, Mika; Karlsen, Tom Hemming; Ericzon, Bo-Göran; Foss, Aksel & Rasmussen, Allan [Show all 15 contributors for this article] (2015). Differences in long-term survival among liver transplant recipients and the general population: A population-based nordic study. Hepatology. ISSN 0270-9139. 61(2), p. 668–677. doi: 10.1002/hep.27538.
• Berntsen, Natalie Lie; Klingenberg, Olav; Juran, Brian D.; Benito De Valle, Maria; Lindkvist, Björn & Lazaridis, Konstantinos N. [Show all 9 contributors for this article] (2015). Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis. Gastroenterology. ISSN 0016-5085. 148(5), p. 924–927.e2. doi: 10.1053/j.gastro.2015.01.041.
• Schrumpf, Erik; Boberg, Kirsten Muri & Karlsen, Tom Hemming (2015). Primary sclerosing cholangitis-the Norwegian experience. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 50(6), p. 781–796. doi: 10.3109/00365521.2015.1028996.
• Vedeld, Hege Marie; Andresen, Kim; Eilertsen, Ina Andrassy; Nesbakken, Arild; Seruca, Raquel & Gladhaug, Ivar Prydz [Show all 10 contributors for this article] (2014). The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. International Journal of Cancer. ISSN 0020-7136. 136(4), p. 844–853. doi: 10.1002/ijc.29039.
• Næss, Sigrid; Lie, Benedicte Alexandra; Melum, Espen; Olsson, Marita; Hov, Johannes Espolin Roksund & Croucher, PJP [Show all 15 contributors for this article] (2014). Refinement of the MHC risk map in a Scandinavian primary sclerosing cholangitis population. PLOS ONE. ISSN 1932-6203. 9:e0114486(12). doi: 10.1371/journal.pone.0114486.
• Fosby, Bjarte; Næss, Sigrid; Hov, Johannes Espolin Roksund; Traherne, James; Boberg, Kirsten Muri & Trowsdale, John [Show all 12 contributors for this article] (2014). HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation. World Journal of Gastroenterology (WJG). ISSN 1007-9327. 20(14), p. 3986–4000. doi: 10.3748/wjg.v20.i14.3986.
• Karlsen, Tom Hemming; Vesterhus, Mette & Boberg, Kirsten Muri (2014). Review article: Controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 39(3), p. 282–301. doi: 10.1111/apt.12581.
• Næss, Sigrid; Björnsson, Einar; Anmarkrud, Jarl Andreas; Al Mamari, Said; Juran, Brian D. & Lazaridis, Konstantinos N. [Show all 15 contributors for this article] (2014). Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease. Liver international (Print). ISSN 1478-3223. 34(10), p. 1488–1495. doi: 10.1111/liv.12492.
• Block, M; Jørgensen, Kristin Kaasen; Øresland, Tom; Lindholm, E; Grzyb, Krzysztof & Småstuen, Milada Cvancarova [Show all 9 contributors for this article] (2014). Colectomy for patients with ulcerative colitis and primary sclerosing cholangitis - What next? Journal of Crohn's and Colitis. ISSN 1873-9946. 8(5), p. 421–430. doi: 10.1016/j.crohns.2013.10.008.
• Andersen, Ina Marie Riise; Tengesdal, Guro; Lie, Benedicte Alexandra; Boberg, Kirsten Muri; Karlsen, Tom Hemming & Hov, Johannes Espolin Roksund (2014). Effects of Coffee Consumption, Smoking, and Hormones on Risk for Primary Sclerosing Cholangitis. Clinical Gastroenterology and Hepatology. ISSN 1542-3565. 12(6), p. 1019–1028. doi: 10.1016/j.cgh.2013.09.024.
• Lindstrøm, Lina; Hultcrantz, Rolf; Boberg, Kirsten Muri; Friis-Liby, Ingalill & Bergquist, Annika (2013). Association Between Reduced Levels of Alkaline Phosphatase and Survival Times of Patients With Primary Sclerosing Cholangitis. Clinical Gastroenterology and Hepatology. ISSN 1542-3565. 11(7), p. 841–846. doi: 10.1016/j.cgh.2012.12.032.
• Wannhoff, A; Hov, Johannes Espolin Roksund; Folseraas, Trine; Rupp, C; Friedrich, K & Anmarkrud, Jarl Andreas [Show all 13 contributors for this article] (2013). FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis. Journal of Hepatology. ISSN 0168-8278. 59(6), p. 1278–1284. doi: 10.1016/j.jhep.2013.08.005.
• Hagness, Morten; Foss, Aksel; Line, Pål Dag; Scholz, Tim; Jørgensen, Pål Foyn & Fosby, Bjarte [Show all 13 contributors for this article] (2013). Liver Transplantation for Nonresectable Liver Metastases From Colorectal Cancer. Annals of Surgery. ISSN 0003-4932. 257(5), p. 800–806. doi: 10.1097/SLA.0b013e3182823957.
• Kummen, Martin; Schrumpf, Erik & Boberg, Kirsten Muri (2013). Liver abnormalities in bowel diseases. Baillière's Best Practice & Research : Clinical Gastroenterology. ISSN 1521-6918. 27(4), p. 531–542. doi: 10.1016/j.bpg.2013.06.013. Show summary

  Liver abnormalities are often seen in bowel diseases. Whether these represent aspects of two separate diseases, or if one is causing the other, is not always easy to decide. Extraintestinal manifestations of inflammatory bowel disease (IBD) or coeliac disease are frequently observed. Of these extraintestinal manifestations, hepatic disorders are among the most common. Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis are the most frequent hepatic disorders in IBD and coeliac disease, respectively. Genetic studies have lately elucidated the associations between IBD and PSC, but there is still a long way until we have complete understanding of the molecular aetiology and pathophysiology of these conditions. There is no curative treatment available for PSC, besides liver transplantation. Steatosis and cholelithiasis are also common in IBD, as are signs of hepatic injury due to IBD treatment. Less common liver abnormalities include liver abscesses, hepatic thromboembolic events, granulomatous liver disease and hepatic amyloidosis.

• Karlsen, Tom Hemming & Boberg, Kirsten Muri (2013). Update on primary sclerosing cholangitis. Journal of Hepatology. ISSN 0168-8278. 59(3), p. 571–582. doi: 10.1016/j.jhep.2013.03.015. Full text in Research Archive
• Boberg, Kirsten Muri; Wisløff, Torbjørn; Kjøllesdal, Karl Sæbjørn; Støvring, Henrik & Kristiansen, Ivar Sønbø (2013). Cost and health consequences of treatment of primary biliary cirrhosis with ursodeoxycholic acid. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 38(7), p. 794–803. doi: 10.1111/apt.12435.
• Liu, Jimmy Z.; Hov, Johannes Espolin Roksund; Folseraas, Trine; Ellinghaus, E; Rushbrook, SM & Doncheva, NT [Show all 84 contributors for this article] (2013). Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nature Genetics. ISSN 1061-4036. 45(6), p. 670–675. doi: 10.1038/ng.2616.
• Jørgensen, Kristin Kaasen; Lindstrøm, Lina; Småstuen, Milada Cvancarova; Karlsen, Tom Hemming; Castedal, Maria & Friman, Styrbjörn [Show all 15 contributors for this article] (2013). Immunosuppression after liver transplantation for primary sclerosing cholangitis influences activity of inflammatory bowel disease. Clinical Gastroenterology and Hepatology. ISSN 1542-3565. 11(5), p. 517–523. doi: 10.1016/j.cgh.2012.12.027.
• Ellinghaus, David; Folseraas, Trine; Holm, Kristian; Ellinghaus, Eva; Melum, Espen & Balschun, Tobias [Show all 37 contributors for this article] (2013). Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. Hepatology. ISSN 0270-9139. 58(3), p. 1074–1083. doi: 10.1002/hep.25977.
• Andresen, Kim; Boberg, Kirsten Muri; Vedeld, Hege Marie; Honne, Hilde; Hektoen, Merete & Wadsworth, Christopher A [Show all 13 contributors for this article] (2012). Novel target genes and a valid biomarker panel identified for cholangiocarcinoma. Epigenetics. ISSN 1559-2294. 7(11), p. 1249–1257. doi: 10.4161/epi.22191.
• Haugaa, Håkon; Thorgersen, Ebbe Billmann; Pharo, Anne Margrethe; Boberg, Kirsten Muri; Foss, Aksel & Line, Pål Dag [Show all 13 contributors for this article] (2012). Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts. Liver transplantation. ISSN 1527-6465. 18(12), p. 1421–1429. doi: 10.1002/lt.23503.
• Folseraas, Trine; Melum, Espen; Rausch, Philipp; Juran, Brian D.; Ellinghaus, Eva & Shiryaev, Alexey [Show all 40 contributors for this article] (2012). Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci. Journal of Hepatology. ISSN 0168-8278. 57(2), p. 366–375. doi: 10.1016/j.jhep.2012.03.031.
• Haugaa, Håkon; Thorgersen, Ebbe Billmann; Pharo, Anne Margrethe; Boberg, Kirsten Muri; Foss, Aksel & Line, Pål Dag [Show all 12 contributors for this article] (2012). Early bedside detection of ischemia and rejection in liver transplants by microdialysis. Liver transplantation. ISSN 1527-6465. 18(7), p. 839–849. doi: 10.1002/lt.23425.
• Jørgensen, Kristin Kaasen; Lindstrom, Lina; Cvancarova, Milada; Castedal, Maria; Friman, Styrbjörn & Schrumpf, Erik [Show all 14 contributors for this article] (2012). Colorectal neoplasia in patients with primary sclerosing cholangitis undergoing liver transplantation: a Nordic multicenter study. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 47(8-9), p. 1021–1029. doi: 10.3109/00365521.2012.685754.
• Jørgensen, Kristin Kaasen; Grzyb, Krzysztof; Lundin, Knut E A; Clausen, Ole Petter Fraas; Aamodt, Geir & Schrumpf, Erik [Show all 8 contributors for this article] (2012). Inflammatory bowel disease in patients with primary sclerosing cholangitis: clinical characterization in liver transplanted and non transplanted pateints. Inflammatory Bowel Diseases. ISSN 1078-0998. 18(3), p. 536–545. doi: 10.1002/ibd.21699.
• Lindström, Lars; Boberg, Kirsten Muri; Wikman, Ola; Friis-Liby, Ingalill; Hultcrantz, Rolf & Prytz, Hanne [Show all 13 contributors for this article] (2012). High dose ursodeoxycholic acid in primary sclerosing cholangitis does not prevent colorectal neoplasia. Alimentary Pharmacology and Therapeutics. ISSN 0269-2813. 35(4), p. 451–457. doi: 10.1111/j.1365-2036.2011.04966.x.
• Wiencke, Kristine & Boberg, Kirsten Muri (2011). Current consensus on the management of primary sclerosing cholangitis. Clinics And Research in Hepatology and Gastroenterology. ISSN 2210-7401. 35(12), p. 786–791. doi: 10.1016/j.clinre.2011.04.007. Show summary

  Guidelines for the management of primary sclerosing cholangitis (PSC) have recently been published by both the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD). The current review focuses on the management of PSC, based on these guidelines. There is no established medical therapy for PSC. The role for UDCA in slowing the disease progression and improving survival is as yet unclear, and there are no specific recommendations for the general use of UDCA in this condition. Guidelines recommend that dominant bile duct strictures with significant cholestasis should be treated with biliary dilatation, with or without stenting. Prospective studies to define type, duration, optimal frequency and long-term effects of endoscopic therapy are needed. Liver transplantation is recommended for end stage disease and has excellent results. PSC patients with dysplasia in biliary brush cytology specimens should also be considered for transplantation. There is no evidence-based algorithm for the follow-up of PSC patients, but some regular investigations are recommended (surveillance colonoscopies in patients with IBD and ultrasound to detect gallbladder mass lesions). (C) 2011 Elsevier Masson SAS. All rights reserved.

• Boberg, Kirsten Muri & Lind, Guro Elisabeth (2011). Primary sclerosing cholangitis and malignancy. Baillière's Best Practice & Research : Clinical Gastroenterology. ISSN 1521-6918. 25(6), p. 753–764. doi: 10.1016/j.bpg.2011.10.002.
• Janse, Marcel; Lamberts, LE; Franke, L; Raychaudhuri, S; Ellinghaus, E & Boberg, Kirsten Muri [Show all 33 contributors for this article] (2011). Three Ulcerative Colitis Susceptibility Loci Are Associated with Primary Sclerosing Cholangitis and Indicate a Role for IL2, REL, and CARD9. Hepatology. ISSN 0270-9139. 53(6), p. 1977–1985. doi: 10.1002/hep.24307.
• Melum, Espen; Franke, Andre; Schramm, Christoph; Weismüller, Tobias J.; Gotthardt, Daniel & Offner, Felix A. [Show all 43 contributors for this article] (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nature Genetics. ISSN 1061-4036. 43(1), p. 17–19. doi: 10.1038/ng.728.
• Boberg, Kirsten Muri; Chapman, Roger W.; Hirschfield, Gideon M.; Lohse, Ansgar W.; Manns, Michael P. & Schrumpf, Erik (2011). Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue. Journal of Hepatology. ISSN 0168-8278. 54(2), p. 374–385. doi: 10.1016/j.jhep.2010.09.002.
• Hov, Johannes Espolin Roksund; Kosmoliaptsis, Vasilis; Traherne, James A.; Olsson, Marita; Boberg, Kirsten Muri & Bergquist, Annika [Show all 12 contributors for this article] (2011). Electrostatic Modifications of the Human Leukocyte Antigen-DR P9 Peptide-Binding Pocket and Susceptibility to Primary Sclerosing Cholangitis. Hepatology. ISSN 0270-9139. 53(6), p. 1967–1976. doi: 10.1002/hep.24299.
• Karlsen, Tom Hemming; Schrumpf, Erik & Boberg, Kirsten Muri (2010). Primary sclerosing cholangitis. Baillière's Best Practice & Research : Clinical Gastroenterology. ISSN 1521-6918. 24(5), p. 655–666. doi: 10.1016/j.bpg.2010.07.005.
• Dolgos, Szilviszter; Hartmann, Anders; Isaksen, Gunhild Aker; Simonsen, Svein; Bjørtuft, Øystein & Boberg, Kirsten Muri [Show all 7 contributors for this article] (2010). Osteoporosis is a prevalent finding in patients with solid organ failure awaiting transplantation - a population based study. Clinical Transplantation. ISSN 0902-0063. 24(5), p. E145–E152. doi: 10.1111/j.1399-0012.2010.01231.x.
• Karlsen, Tom Hemming; Schrumpf, Erik & Boberg, Kirsten Muri (2010). Update on primary sclerosing cholangitis. Digestive and Liver Disease. ISSN 1590-8658. 42(6), p. 390–400. doi: 10.1016/j.dld.2010.01.011.
• Hov, Johannes Espolin Roksund; Keitel, V; Lærdahl, Jon Kristen; Spomer, L; Ellinghaus, E & ElSharawy, A [Show all 36 contributors for this article] (2010). Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis. PLOS ONE. ISSN 1932-6203. 5(8). doi: 10.1371/journal.pone.0012403.
• Chapman, R; Fevery, J; Kalloo, A; Nagorney, DM; Boberg, Kirsten Muri & Shneider, B [Show all 7 contributors for this article] (2010). Diagnosis and Management of Primary Sclerosing Cholangitis. Hepatology. ISSN 0270-9139. 51(2), p. 660–678. doi: 10.1002/hep.23294. Show summary

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• Ponsioen, Cyriel Y.; Reitsma, JB; Boberg, Kirsten Muri; Aabakken, Lars; Rauws, Erik & Schrumpf, Erik (2010). Validation of a cholangiographic prognostic model in primary sclerosing cholangitis. Endoscopy. ISSN 0013-726X. 42(9), p. 742–747. doi: 10.1055/s-0030-1255527.
• Karlsen, Tom Hemming; Franke, Andre; Melum, Espen; Kaser, Arthur; Hov, Johannes Espolin Roksund & Balschun, Tobias [Show all 32 contributors for this article] (2010). Genome-Wide Association Analysis in Primary Sclerosing Cholangitis. Gastroenterology. ISSN 0016-5085. 138(3), p. 1102–1111. doi: 10.1053/j.gastro.2009.11.046.
• Forsbring, Monika; Vik, Erik Sebastian; Dalhus, Bjørn; Karlsen, Tom Hemming; Bergquist, A. & Schrumpf, Erik [Show all 9 contributors for this article] (2009). Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma. Carcinogenesis. ISSN 0143-3334. 30(7), p. 1147–1154. doi: 10.1093/carcin/bgp118.
• Yu, X; Wieczorek, S.; Franke, Andre; Yin, Hang; Pierer, M. & Sina, Christina [Show all 16 contributors for this article] (2009). Association of UCP2-866 G/A polymorphism with chronic inflammatory diseases. Genes and Immunity. ISSN 1466-4879. 10(6), p. 601–605. doi: 10.1038/gene.2009.29.
• Melum, Espen; Karlsen, TH; Schrumpf, Erik; Bergquist, A; Thorsby, Erik & Boberg, Kirsten Muri [Show all 7 contributors for this article] (2008). Cholanglocarcinoma in primary sclerosing cholangitis is associated with NKG2D Polymorphisms. Hepatology. ISSN 0270-9139. 47, p. 90–96. doi: 10.1002/hep.21964.
• Wiencke, Kristine; Karlsen, Hemming Tom; Boberg, Kirsten Muri; Thorsby, Erik; Schrumpf, Erik & Lie, Benedicte Alexandra [Show all 7 contributors for this article] (2007). Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes. Tissue Antigens. ISSN 0001-2815. 69, p. 161–169. doi: 10.1111/j.1399-0039.2006.00738.x.
• Karlsen, Hemming Tom; Boberg, Kirsten Muri; Vatn, Morten H; Bergquist, A; Hampe, J & Schrumpf, Erik [Show all 9 contributors for this article] (2007). Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis. Genes and Immunity. ISSN 1466-4879. 8. doi: 10.1038/sj.gene.6364377.
• Karlsen, Hemming Tom; Boberg, Kirsten Muri; Olsson, M; Sun, JY; Senitzer, D & Bergquist, A [Show all 9 contributors for this article] (2007). Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis. Journal of Hepatology. ISSN 0168-8278. 46. doi: 10.1016/j.jhep.2007.01.032.
• Wiencke, Kristine; Boberg, Kirsten Muri; Donaldson, P; Harbo, Hanne Flinstad; Ling, V & Schrumpf, Erik [Show all 7 contributors for this article] (2006). No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 41.
• Boberg, Kirsten Muri; Jebsen, Peter Wilhelm; Clausen, Ole Petter Fraas; Foss, Aksel; Aabakken, Lars & Schrumpf, Erik (2006). Diagnostic benefit of biliary brush cytology in cholangiocarcinoma in primary sclerosing cholangitis. Journal of Hepatology. ISSN 0168-8278. 45, p. 568–574.
• Berstad, Audun Elnæs; Aabakken, Lars; Smith, Hans-Jørgen; Aasen, Steinar; Boberg, Kirsten Muri & Schrumpf, Erik (2006). Diagnostic accuracy of magnetic resonance and endoscopic retrograde cholangiography in primary sclerosing cholangitis. Clinical Gastroenterology and Hepatology. ISSN 1542-3565. 4(4), p. 514–520.
• Bowlus, Christopher L.; Karlsen, Tom Hemming; Broomé, Ulrika; Thorsby, Erik; Vatn, Morten & the, IBSEN study group [Show all 9 contributors for this article] (2006). Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. Journal of Hepatology. ISSN 0168-8278. 45(5), p. 704–710.

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• Hole, Mikal Jacob; Jørgensen, Kristin Kaasen; Holm, Kristian; Braadland, Peder Rustøen; Meyer-Myklestad, Malin Holm & Medhus, Asle Wilhelm [Show all 13 contributors for this article] (2023). Reply: The mucosal gut signature in primary sclerosing cholangitis before and after liver transplantation. Is the dysbiosis index really predictive for the recurrence of PSC? Hepatology. ISSN 0270-9139. 77(6), p. E188–E189. doi: 10.1097/HEP.0000000000000340.
• Dueland, Svein; Guren, Tormod Kyrre; Boberg, Kirsten Muri; Reims, Henrik Mikael; Grzyb, Krzysztof & Aamdal, Steinar [Show all 8 contributors for this article] (2017). Acute liver graft rejection after ipilimumab therapy. Annals of Oncology. ISSN 0923-7534. 28(10), p. 2619–2620. doi: 10.1093/annonc/mdx281.
• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M. & Boberg, Kirsten Muri [Show all 10 contributors for this article] (2015). P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis. Show summary

  Background and Aims: Trimethylamine-N-oxide (TMAO) is produced in the liver from trimethylamine, which is exclusively generated by gut bacteria from dietary choline and carnitine found in e.g. red meat and dairy products. TMAO influences bile acid levels, metabolism and potentially also inflammation. Given the production in the liver, link to the gut microbiota and bile acid homeostasis, we aimed to investigate the regulation of TMAO in primary sclerosing cholangitis (PSC). Methods: We measured serum TMAO in 305 PSC patients, 90 ulcerative colitis (UC) patients and 99 healthy controls (HC), with a median age (male %) of 41 (76), 38 (51) and 40 (60), respectively. Reduced liver function was defined by increased prothrombin time (International Normalized Ratio >1.2 or Normotest <70). Results: TMAO level was lower in PSC patients than in UC and HC (medians 3.1, 4.0 and 3.5, respectively, p < 0.05 versus HC and UC). We hypothesized that this could be explained by reduced liver function affecting TMAO production. In line with this, TMAO in PSC with reduced liver function, but not TMAO in those with normal liver function, was lower than in HC (p < 0.05). The TMAO level in UC was higher than in PSC irrespective of liver function (p < 0.05), while TMAO was similar in PSC patients with and without inflammatory bowel disease. Focusing on PSC patients with normal liver function, the TMAO level was higher in patients reaching an end-point during follow-up (liver transplantation, n = 70, or all-cause death, n = 21) than those without (median 4.6 versus 2.7, p = 0.001). AUROC-analysis yielded an AUC of 0.64 (p < 0.001) with a suggested optimal TMAO cut-off of 4.1mM. When stratified by this value, PSC patients with high TMAO exhibited shorter transplantation-free survival than patients with low TMAO (median 3.0 versus 16.2 years, p < 0.001, Figure 1). In Cox regressions, TMAO>4.1mM and Mayo risk score were independently associated with transplantation-free survival, with HR 2.0 (95% CI 1.2–3.1, p = 0.005) and 1.5 (95% CI 1.2–1.8, p < 0.001), respectively. Conclusions: PSC patients with impaired liver function had decreased TMAO level, suggesting that TMAO may be influenced by reduced liver function. On the other hand, in PSC patients with normal liver function, elevated TMAO was associated with a shorter liver transplantation-free survival, suggesting that dietary factors and gut microbiota profile may be relevant for the disease prognosis in PSC.

• Kummen, Martin; Vesterhus, Mette; Trøseid, Marius; Moum, Bjørn; Svardal, Asbjørn M. & Boberg, Kirsten Muri [Show all 10 contributors for this article] (2015). MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS.
• Wadsworth, C.A.; Horneffer-van Der Sluis, VM; Zabron, A.; Boberg, Kirsten Muri; Pereira, SP & Taylor-Robinson, SD [Show all 8 contributors for this article] (2012). INCREASED LEVELS OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) IN THE PLASMA OF CHOLANGIOCARCINOMA PATIENTS. Journal of Hepatology. ISSN 0168-8278. 56, p. S130–S130.
• Wadsworth, C.A.; Horneffer-van Der Sluis, VM; Zabron, A.; Boberg, Kirsten Muri; Pereira, SP & Edwards, RJ [Show all 8 contributors for this article] (2012). INCREASED LEVELS OF NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN (NGAL) IN THE PLASMA OF CHOLANGIOCARCINOMA PATIENTS. Gut. ISSN 0017-5749. 61, p. A350–A351. doi: 10.1136/gutjnl-2012-302514d.133.
• Hagness, Morten; Foss, Aksel; Line, Pål Dag; Scholz, Tim; Jørgensen, Pål Foyn & Fosby, Bjarte [Show all 13 contributors for this article] (2012). Liver Transplantation for Non-Resectable Liver Metastases from Colorectal Cancer. Liver transplantation. ISSN 1527-6465. 18, p. S140–S140.
• Thorsen, Trygve; Boberg, Kirsten Muri; Jørgensen, Pål Foyn; Karlsen, Tom Hemming & Foss, Aksel (2012). Liver Transplantation Using ABO-Incompatible Donors; a Single Center Experience of 23 Adult Recipients. Liver transplantation. ISSN 1527-6465. 18, p. S259–S259.
• Fosby, Bjarte; Næss, Sigrid; Hov, Johannes Espolin Roksund; Traherne, James A.; Boberg, Kirsten Muri & Trowsdale, John [Show all 11 contributors for this article] (2012). Increased risk of acute rejection after liver transplantation in patients carrying HLA variants related to primary sclerosing cholangitis. Hepatology. ISSN 0270-9139. 56, p. 507A–508A.
• Naess, Sigrid; Anmarkrud, Jarl Andreas; Björnsson, Einar; Al Mamari, Said; Juran, Brian D. & Lazaridis, Konstantios N [Show all 13 contributors for this article] (2012). HLA associations in small-duct compared with large-duct primary sclerosing cholangitis. Hepatology. ISSN 0270-9139. 56, p. 1134A–1134A.
• Lindstrom, Lina; Boberg, Kirsten Muri; Friis-Liby, Ingalill; Hultcrantz, Rolf & Bergquist, Annika (2012). A reduction in alkaline phosphatase levels is associated to improved prognosis in primary sclerosing cholangitis: A 14 year follow up of the Scandinavian ursodeoxycholic acid trial. Hepatology. ISSN 0270-9139. 56, p. 247A–247A.
• Tengesdal, Guro; Lie, Benedicte Alexandra; Boberg, Kirsten Muri; Karlsen, Tom Hemming & Hov, Johannes Espolin Roksund (2012). Survey of nongenetic risk factors suggests that tobacco exposure, coffee consumption, the use of oral contraception and the number of pregnancies could affect disease risk or presentation of primary sclerosing cholangitis. Hepatology. ISSN 0270-9139. 56, p. 301A–301A.
• Andresen, K.; Boberg, Kirsten Muri; Eknaes, M; Honne, Hilde; Schrumpf, E & Lothe, Ragnhild A [Show all 7 contributors for this article] (2010). Array-based approach for early tumour detection in the biliary tract. European Journal of Cancer. ISSN 0959-8049. 8(5), p. 44–44.
• Boberg, Kirsten Muri; Lohse, AW; Hennes, EM; Dienes, HP; Heathcote, EJ & Chapman, RW [Show all 7 contributors for this article] (2009). ASSESSMENT OF 479 PATIENTS WITH AUTOIMMUNE LIVER DISEASES ACCORDING TO THE IAIHG SCORING SYSTEM FOR AUTOIMMUNE HEPATITIS DOES NOT SUPPORT THE CONTENTION OF OVERLAP SYNDROMES AS SEPARATE DIAGNOSTIC ENTITIES. Hepatology. ISSN 0270-9139. 50(4), p. 1009A–1009A.
• Boberg, Kirsten Muri (2009). Diagnosis of cholangiocarcinoma in PSC. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 44, p. 28–29.
• Boberg, Kirsten Muri (2008). PSC and dysplasia surveillance. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 43, p. 23–23.
• Melum, Espen; Karlsen, TH; Bergquist, A; Schrumpf, Erik & Boberg, Kirsten Muri (2008). An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis. American Journal of Gastroenterology. ISSN 0002-9270. 103, p. 1045–1045.
• Wiencke, Kristine; Karlsen, TH; Boberg, Kirsten Muri; Harbo, Hanne Flinstad; Lie, Benedicte Alexandra & Thorsby, Erik [Show all 8 contributors for this article] (2005). Association to the HLA-DR6 haplotype in PSC: Additional effects in the HLA class I/extended class I region. Journal of Hepatology. ISSN 0168-8278. 42.
• Karlsen, Tom Hemming & Boberg, Kirsten Muri (2007). On the genetic influence on disease susceptibility and disease progression in primary sclerosing cholangitis. Unipub forlag. ISSN 978-82-8072-709-1.

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