Knut Arvid Kirkebøen

• Hoff, Ingrid Elise Taraldsrud; Hisdal, Jonny; Landsverk, Svein A.; Røislien, Jo; Kirkebøen, Knut Arvid & Høiseth, Lars Øivind (2019). Respiratory variations in pulse pressure and photoplethysmographic waveform amplitude during positive expiratory pressure and continuous positive airway pressure in a model of progressive hypovolemia. PLOS ONE. ISSN 1932-6203. 14:e0223071(9), p. 1–15. doi: 10.1371/journal.pone.0223071. Full text in Research Archive
• Hisdal, Jonny; Landsverk, Svein A.; Hoff, Ingrid Elise Taraldsrud; Hagen, Ove Andreas; Kirkebøen, Knut Arvid & Høiseth, Lars Øivind (2019). Associations between changes in precerebral blood flow and cerebral oximetry in the lower body negative pressure model of hypovolemia in healthy volunteers. PLOS ONE. ISSN 1932-6203. 14(6), p. 1–14. doi: 10.1371/journal.pone.0219154. Full text in Research Archive
• Hoff, Ingrid Elise Taraldsrud; Høiseth, Lars Øivind; Kirkebøen, Knut Arvid & Landsverk, Svein A. (2019). Volumetric and end-tidal capnography for the detection of cardiac output changes in mechanically ventilated patients early after open heart surgery. Critical Care Research and Practice. ISSN 2090-1305. 2019:6393649, p. 1–9. doi: 10.1155/2019/6393649. Full text in Research Archive
• Hagen, Ove Andreas; Høiseth, Lars Øivind; Roslin, Andre; Landsverk, Svein A.; Woldbæk, Per R & Pripp, Are Hugo [Show all 8 contributors for this article] (2016). Impact of Norepinephrine on Regional Cerebral Oxygenation During Cardiopulmonary Bypass. Journal of Cardiothoracic and Vascular Anesthesia. ISSN 1053-0770. 30(2), p. 291–296. doi: 10.1053/j.jvca.2015.12.015.
• Høiseth, Lars Øivind; Hoff, Ingrid E Taraldsrud; Hagen, Ove Andreas; Kirkebøen, Knut Arvid & Landsverk, Svein A. (2016). Respiratory variations in the photoplethysmographic waveform amplitude depend on type of pulse oximetry device. Journal of clinical monitoring and computing. ISSN 1387-1307. 30(3), p. 317–325. doi: 10.1007/s10877-015-9720-9.
• Høiseth, Lars Øivind; Hisdal, Jonny; Hoff, Ingrid E Taraldsrud; Hagen, Ove Andreas; Landsverk, Svein A. & Kirkebøen, Knut Arvid (2015). Tissue Oxygen Saturation and Finger Perfusion Index in Central Hypovolemia: Influence of Pain. Critical Care Medicine. ISSN 0090-3493. 43(4). doi: 10.1097/CCM.0000000000000766. Show summary

  Objectives: Tissue oxygen saturation and peripheral perfusion index are proposed as early indirect markers of hypovolemia in trauma patients. Hypovolemia is associated with increased sympathetic nervous activity. However, many other stimuli, such as pain, also increase sympathetic activity. Since pain is often present in trauma patients, its effect on the indirect measures of hypovolemia needs to be clarified. The aim of this study was, therefore, to explore the effects of hypovolemia and pain on tissue oxygen saturation (measurement sites: cerebral, deltoid, forearm, and thenar) and finger photoplethysmographic perfusion index. Design: Experimental study. Setting: University hospital clinical circulation and research laboratory. Subjects: Twenty healthy volunteers. Interventions: Central hypovolemia was induced with lower body negative pressure (–60 mm Hg) and pain by the cold pressor test (ice water exposure). Interventions were performed in a 2 × 2 fashion with the combination of lower body negative pressure or not (normovolemia), and ice water or not (sham). Each subject was thus exposed to four experimental sequences, each lasting for 8 minutes. Measurements and Main Results: Measurements were averaged over 30 seconds. For each person and sequence, the minimal value was analyzed. Tissue oxygenation in all measurement sites and finger perfusion index were reduced during hypovolemia/sham compared with normovolemia/sham. Tissue oxygen saturation (except cerebral) and perfusion index were reduced by pain during normovolemia. There was a larger reduction in tissue oxygenation (all measurement sites) and perfusion index during hypovolemia and pain than during normovolemia and pain. Conclusions: Pain (cold pressor test) reduces tissue oxygen saturation in all measurement sites (except cerebral) and perfusion index. In the presence of pain, tissue oxygen saturation and perfusion index are further reduced by hypovolemia (lower body negative pressure, –60 mm Hg). Thus, pain must be considered when evaluating tissue oxygen saturation and perfusion index as markers of hypovolemia in trauma patients.

• Høiseth, Lars Øivind; Hoff, Ingrid E Taraldsrud; Hagen, Ove Andreas; Landsverk, Svein A. & Kirkebøen, Knut Arvid (2015). Agreement between stroke volume measured by oesophageal Doppler and uncalibrated pulse contour analysis during fluid loads in severe aortic stenosis. Journal of clinical monitoring and computing. ISSN 1387-1307. 29(4), p. 435–441. doi: 10.1007/s10877-015-9666-y.
• Lindholm, Espen; Aune, Erlend; Seljeflot, Ingebjørg; Otterstad, Jan Erik & Kirkebøen, Knut Arvid (2015). Biomarkers of inflammation in major vascular surgery: a prospective randomised trial . Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 59(6), p. 773–787. doi: 10.1111/aas.12466.
• Hoff, Ingrid E Taraldsrud; Høiseth, Lars Øivind; Hisdal, Jonny; Røislien, Jo; Landsverk, Svein A. & Kirkebøen, Knut Arvid (2014). Respiratory variations in pulse pressure reflect central hypovolemia during noninvasive positive pressure ventilation. Critical Care Research and Practice. ISSN 2090-1305. 2014. doi: 10.1155/2014/712728.
• Høiseth, Lars Øivind; Hoff, Ingrid E Taraldsrud; Hagen, Ove Andreas; Landsverk, Svein A. & Kirkebøen, Knut Arvid (2014). Dynamic variables and fluid responsiveness in patients for aortic stenosis surgery. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 58(7), p. 826–834. doi: 10.1111/aas.12328.
• Lindholm, Espen; Aune, Erlend; Frøland, Gisle S.; Kirkebøen, Knut Arvid & Otterstad, Jan Erik (2014). Analysis of transthoracic echocardiographic data in major vascular surgery from a prospective randomised trial comparing sevoflurane and fentanyl with propofol and remifentanil anaesthesia. Anaesthesia. ISSN 0003-2409. 69(6), p. 558–572. doi: 10.1111/anae.12604.
• Kvandal, Per; Sheppard, Lawrence; Landsverk, Svein A.; Stefanovska, Aneta & Kirkebøen, Knut Arvid (2013). Impaired cerebrovascular reactivity after acute traumatic brain injury can be detected by wavelet phase coherence analysis of the intracranial and arterial blood pressure signals. Journal of clinical monitoring and computing. ISSN 1387-1307. 27(4), p. 375–383. doi: 10.1007/s10877-013-9484-z.
• Lindholm, Espen; Aune, Erlend; Noren, Camilla; Seljeflot, Ingebjørg; Hayes, Thomas & Otterstad, Jan Erik [Show all 7 contributors for this article] (2013). The Anesthesia in abdominal Aortic Surgery. A prospective, randomized, controlled trial comparing Troponin T release with Fentanyl-Svoflutane and Propofol-remifentanil anesthesia in major vascular sugery. Anesthesiology. ISSN 0003-3022. 119(4), p. 802–812. doi: 10.1097/ALN.0b013e31829bd883.
• Høiseth, Lars Øivind; Hoff, Ingrid E Taraldsrud; Myre, Kirsti; Landsverk, Svein A. & Kirkebøen, Knut Arvid (2012). Dynamic variables of fluid responsiveness during pneumoperitoneum and laparoscopic surgery. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 56(6), p. 777–786. doi: 10.1111/j.1399-6576.2011.02641.x.
• Lindholm, Espen; Seljeflot, Ingebjørg; Aune, Erlend & Kirkebøen, Knut Arvid (2012). Proinflammatory cytokines and complement activation in salvaged blood from abdominal aortic aneurism surgery and total hip replacement surgery. Transfusion. ISSN 0041-1132. 52(8), p. 1761–1769. doi: 10.1111/j.1537-2995.2011.03528.x.
• Antonsen, Lars Prag & Kirkebøen, Knut Arvid (2012). Evaluation of Fluid Responsiveness: Is Photoplethysmography a Noninvasive Alternative? Anesthesiology Research and Practice. ISSN 1687-6962. 2012. doi: 10.1155/2012/617380. Show summary

  Background. Goal-directed fluid therapy reduces morbidity and mortality in various clinical settings. Respiratory variations in photoplethysmography are proposed as a noninvasive alternative to predict fluid responsiveness during mechanical ventilation. This paper aims to critically evaluate current data on the ability of photoplethysmography to predict fluid responsiveness. Method. Primary searches were performed in PubMed, Medline, and Embase on November 10, 2011. Results. 14 papers evaluating photoplethysmography and fluid responsiveness were found. Nine studies calculated areas under the receiver operating characteristic curves for Δ POP (>0.85 in four, 0.75–0.85 in one, and <0.75 in four studies) and seven for PVI (values ranging from 0.54 to 0.98). Correlations between Δ POP/PVI and Δ PP/other dynamic variables vary substantially. Conclusion. Although photoplethysmography is a promising technique, predictive values and correlations with other hemodynamic variables indicating fluid responsiveness vary substantially. Presently, it is not documented that photoplethysmography is adequately valid and reliable to be included in clinical practice for evaluation of fluid responsiveness.

• MESIC, HARIS; Kirkebøen, Knut Arvid & Bains, Ravi (2012). The Importance of a Skin Bridge in Peripheral Tissue Perfusion in Perforator Flaps. Plastic and Reconstructive Surgery. ISSN 0032-1052. 129(3), p. 428E–434E. doi: 10.1097/PRS.0b013e31824423f8.
• Høiseth, Lars Øivind; Hoff, Ingrid E Taraldsrud; Skare, Øivind; Kirkebøen, Knut-Arvid & Landsverk, Svein A. (2011). Photoplethysmographic and pulse pressure variations during abdominal surgery. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 55(10), p. 1221–1230. doi: 10.1111/j.1399-6576.2011.02527.x.
• Kirkebøen, Knut-Arvid; Lindholm, Espen & Ræder, Johan (2010). Valg av anestesimetode og anestesimidler. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(4), p. 388–391. doi: 10.4045/tidsskr.08.0370.
• Veel, Terje; Bugge, Jan Frederik; Kirkebøen, Knut Arvid & Pleym, Hilde (2010). Anestesi ved åpen hjertekirurgi hos voksne. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(6), p. 618–622.
• Kirkebøen, Knut-Arvid; LINDHOLM, ESPEN & Ræder, Johan (2010). Valg av anestesimetode og anestesimidler. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 130(4), p. 388–391. doi: 10.4045/tidsskr.08.0370.
• JONASSEN, ALF ARNE; Petersen, AJ; Mohr, Stephan; Andersson, C; Skattum, Jorunn Pettersen & Kvernebo, Knut [Show all 9 contributors for this article] (2004). Sevoflurane-induced malignant hyperthermia during cardiopulmonary bypass and moderate hypothermia. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 48(8), p. 1062–1065.

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• Høiseth, Lars Øivind; Hisdal, Jonny; Landsverk, Svein A. & Kirkebøen, Knut Arvid (2015). The authors reply: Pain and tissue oxygenation. Critical Care Medicine. ISSN 0090-3493. 43(10), p. e463–e464. doi: 10.1097/CCM.0000000000001206.
• Kirkebøen, Knut Arvid (2014). Adenosine as a regulator of NFκB activation. Acta Physiologica. ISSN 1748-1708. 210(3), p. 465–467. doi: 10.1111/apha.12203.
• Lindholm, Espen; Aune, Erlend; Otterstad, Jan Erik & Kirkebøen, Knut Arvid (2014). In reply. Anesthesiology. ISSN 0003-3022. 120(5), p. 1292–1297. doi: 10.1097/ALN.0000000000000188.
• Mohr, Stefan; Jonassen, Alf; Pettersen, Arne & Kirkebøen, Knut-Arvid (2004). Changes in clinical picture of malignant hyperthermia, consequences for monitoring.

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