Knut Erik Hovda

• Vallersnes, Odd Martin; Dines, Alison M.; Wood, David M.; Heyerdahl, Fridtjof; Hovda, Knut Erik & Yates, Christopher [Show all 20 contributors for this article] (2023). Self-discharge during treatment for acute recreational drug toxicity: an observational study from emergency departments in seven European countries. International Journal of Emergency Medicine. ISSN 1865-1372. 16(1). doi: 10.1186/s12245-023-00566-1. Full text in Research Archive
• Noseda, Roberta; Franchi, Matteo; Pagnamenta, Alberto; Müller, Laura; Dines, Alison M. & Giraudon, Isabelle [Show all 16 contributors for this article] (2023). Determinants of Admission to Critical Care Following Acute Recreational Drug Toxicity: A Euro-DEN Plus Study. Journal of Clinical Medicine. ISSN 2077-0383. 12(18). doi: 10.3390/jcm12185970. Full text in Research Archive
• Lao, Yvonne Elisabeth; Heyerdahl, Fridtjof; Jacobsen, Dag & Hovda, Knut Erik (2022). An enzymatic assay with formate oxidase for point-of-care diagnosis of methanol poisoning. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 131(6), p. 547–554. doi: 10.1111/bcpt.13789. Full text in Research Archive
• Miró, Òscar; Burillo-Putze, Guillermo; Schmid, Yasmin; Salgado, Emilio; Liechti, Matthias E & Dines, Alison M. [Show all 14 contributors for this article] (2022). Severity of emergency department presentations due to acute drug toxicity in Europe: a longitudinal analysis over a 6-year period (2014–2019) stratified by sex. European journal of emergency medicine. ISSN 0969-9546. doi: 10.1097/MEJ.0000000000000978.
• Crulli, Benjamin; Dines, Alison M.; Blanco, Georgina; Giraudon, Isabelle; Eyer, Florian & Liechti, Matthias E [Show all 13 contributors for this article] (2022). Novel psychoactive substances-related presentations to the emergency departments of the European drug emergencies network plus (Euro-DEN plus) over the six-year period 2014–2019. Clinical Toxicology. ISSN 1556-3650. doi: 10.1080/15563650.2022.2137524. Full text in Research Archive
• Schmid, Yasmin; Galicia, Miguel; Vogt, Severin B.; Liechti, Matthias E.; Burillo-Putze, Guillermo & Dargan, Paul I. [Show all 13 contributors for this article] (2022). Differences in clinical features associated with cannabis intoxication in presentations to European emergency departments according to patient age and sex. Clinical Toxicology. ISSN 1556-3650. 60(8), p. 912–919. doi: 10.1080/15563650.2022.2060116.
• Ingebrigtsen, Erlend; Persett, Per Sverre; Brekke, Mette; Heyerdahl, Fridtjof; Hovda, Knut Erik & Vallersnes, Odd Martin (2022). Poisoning with central stimulant drugs: an observational study from Oslo, Norway. International Journal of Emergency Medicine. ISSN 1865-1372. 15(1). doi: 10.1186/s12245-022-00457-x. Full text in Research Archive
• Mahdavi, Seyed Amirhosein; Zamani, Nasim; Mcdonald, Rebecca Silvia; Akhgari, Maryam; Kolahi, Ali-Asghar & Gheshlaghi, Farzad [Show all 30 contributors for this article] (2022). A cross-sectional multicenter linkage study of hospital admissions and mortality due to methanol poisoning in Iranian adults during the COVID-19 pandemic. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-14007-1. Full text in Research Archive
• Ruszkiewicz, Dorota M; Myers, Renelle; Henderson, Ben; Yusof, Hazim; Meister, Austin & Moreno, Sergi [Show all 15 contributors for this article] (2022). Peppermint protocol: First results for gas chromatography-ion mobility spectrometry. Journal of Breath Research. ISSN 1752-7155. 16(3). doi: 10.1088/1752-7163/ac6ca0.
• Roberts, Darren M.; Hoffman, Robert S.; Brent, Jeffrey; Lavergne, Valéry; Hovda, Knut Erik & Porter, William H. [Show all 8 contributors for this article] (2022). The serum glycolate concentration: its prognostic value and its correlation to surrogate markers in ethylene glycol exposures. Clinical Toxicology. ISSN 1556-3650. doi: 10.1080/15563650.2022.2049811.
• Dhanarisi, Jeevan; Tzotzolaki, Tanita Maria; Vasileva, Ana-Mariya D.; Kjellberg, Matti A.; Hakulinen, Hanna & Vanninen, Paula [Show all 10 contributors for this article] (2022). Osmolal and anion gaps after acute self-poisoning with agricultural formulations of the organophosphorus insecticides profenofos and diazinon: A pilot study. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 130(2), p. 320–327. doi: 10.1111/bcpt.13686.
• Heier, Eva-Carina; Eyer, Florian; Rabe, Christian; Geith, Stefanie; Dargan, Paul I & Wood, David M. [Show all 15 contributors for this article] (2022). Clinical effect of ethanol co-use in patients with acute drug toxicity involving the use of central nervous system depressant recreational drugs. European journal of emergency medicine. ISSN 0969-9546. 29(4), p. 291–300. doi: 10.1097/MEJ.0000000000000932.
• Beaulieu, Jessie; Roberts, Darren M.; Gosselin, Sophie; Hoffman, Robert S.; Lavergne, Valery & Hovda, Knut Erik [Show all 10 contributors for this article] (2022). Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review. Clinical Toxicology. ISSN 1556-3650. doi: 10.1080/15563650.2022.2049810.
• Lao, Yvonne Elisabeth; Vartdal, Trond; Frøyshov, Sten; Latimer, Brian; Kværner, Christiane & Mataric, Marija [Show all 11 contributors for this article] (2021). Fomepizole dosing during continuous renal replacement therapy–an observational study. Clinical Toxicology. ISSN 1556-3650. doi: 10.1080/15563650.2021.1980581. Full text in Research Archive
• Leaper, Craig; Dines, Alison M.; Dargan, Paul I.; Yates, Christopher; Hovda, Knut Erik & Heyerdahl, Fridtjof [Show all 8 contributors for this article] (2021). Impact of pregabalin co-use in patients presenting with acute heroin toxicity to the European Drug Emergencies Network plus project. European journal of emergency medicine. ISSN 0969-9546. 28(2), p. 144–146. doi: 10.1097/MEJ.0000000000000738.
• Waldman, Wojciech; Kabata, Pm; Dines, Alison M.; Wood, David M.; Yates, Christopher & Heyerdahl, Fridtjof [Show all 10 contributors for this article] (2021). Rhabdomyolysis related to acute recreational drug toxicity—A Euro-DEN study. PLOS ONE. ISSN 1932-6203. 16(3), p. 1–11. doi: 10.1371/journal.pone.0246297.
• Noseda, Roberta; Schmid, Yasmin; Scholz, Irene; Liakoni, Evangelia; Liechti, Matthias E. & Dargan, Paul I. [Show all 36 contributors for this article] (2021). MDMA-related presentations to the emergency departments of the European Drug Emergencies Network plus (Euro-DEN Plus) over the four-year period 2014-2017. Clinical Toxicology. ISSN 1556-3650. 59(2), p. 131–137. doi: 10.1080/15563650.2020.1784914.
• Lao, Yvonne Elisabeth; Goffeng, Anne; Spillum, Barbro Johanne; Jacobsen, Dag; Nakstad, Espen Rostrup & Hovda, Knut Erik (2021). A survey of the antidote preparedness in Norwegian hospitals. European Journal of Hospital Pharmacy (EJHP). ISSN 2047-9956. p. 1–5. doi: 10.1136/ejhpharm-2020-002544. Full text in Research Archive
• Miro, Oscar; Waring, W. Stephen; Dargan, Paul I.; Wood, David M.; Dines, Alison M. & Yates, Christopher [Show all 25 contributors for this article] (2021). Variation of drugs involved in acute drug toxicity presentations based on age and sex: an epidemiological approach based on European emergency departments. Clinical Toxicology. ISSN 1556-3650. doi: 10.1080/15563650.2021.1884693.
• Layne, Kerry A.; Dargan, Paul I.; Dines, Alison M.; Leaper, Craig; Yates, Christopher & Hovda, Knut Erik [Show all 10 contributors for this article] (2020). Acute toxicity related to misuse (nonmedical use) of tramadol: Experience of the European Drug Emergencies Network Plus. British Journal of Clinical Pharmacology. ISSN 0306-5251. p. 1–8. doi: 10.1111/bcp.14408.
• Lao, Yvonne Elisabeth; Molden, Espen; Kringen, Marianne K.; Annexstad, Ellen Johanne; Sæverud, Håvard Andreassen & Jacobsen, Dag [Show all 7 contributors for this article] (2020). Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 127(1), p. 47–51. doi: 10.1111/bcpt.13389. Full text in Research Archive
• Gundem, Trine; Olasveengen, Theresa M.; Hovda, Knut Erik; Gaustad, Knut; Schøndorf, Christina Luise & Rostrup, Morten [Show all 11 contributors for this article] (2020). Ventilasjonsstotte for hypoksemiske intensivpasienter med covid-19. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(11), p. 1–10. doi: 10.4045/tidsskr.20.0445. Full text in Research Archive
• Galicia, Miguel; Dargan, Paul I.; Dines, Alison M.; Yates, Christopher; Heyerdahl, Fridtjof & Hovda, Knut Erik [Show all 9 contributors for this article] (2019). Clinical relevance of ethanol coingestion in patients with GHB/GBL intoxication. Toxicology Letters. ISSN 0378-4274. 314, p. 37–42. doi: 10.1016/j.toxlet.2019.07.001.
• Wood, David M.; De La Rue, Luke; Hosin, Ali A; Jurgens, Gesche; Liakoni, Evangelia & Heyerdahl, Fridtjof [Show all 11 contributors for this article] (2019). Poor Identification of Emergency Department Acute Recreational Drug Toxicity Presentations Using Routine Hospital Coding Systems: the Experience in Denmark, Switzerland and the UK. Journal of Medical Toxicology. ISSN 1556-9039. 15(2), p. 112–120. doi: 10.1007/s13181-018-0687-z.
• Wolfe, Caitlin E; Wood, David M.; Dines, Alison; Whatley, Benjamin P; Yates, Christopher & Heyerdahl, Fridtjof [Show all 9 contributors for this article] (2019). Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set. Neurotoxicology. ISSN 0161-813X. 73, p. 183–187. doi: 10.1016/j.neuro.2019.04.003.
• Hassanian-Moghaddam, Hossein; Zamani, Nasim; Roberts, Darren M.; Brent, Jeffrey; McMartin, Kenneth & Aaron, Cynthia [Show all 22 contributors for this article] (2019). Consensus statements on the approach to patients in a methanol poisoning outbreak. Clinical Toxicology. ISSN 1556-3650. p. 1–9. doi: 10.1080/15563650.2019.1636992.
• Miro, Oscar; Dargan, Paul I; Wood, David M.; Dines, Alison M.; Yates, Christopher & Heyerdahl, Fridtjof [Show all 9 contributors for this article] (2019). Epidemiology, clinical features and management of patients presenting to European emergency departments with acute cocaine toxicity: comparison between powder cocaine and crack cocaine cases. Clinical Toxicology. ISSN 1556-3650. 57(8), p. 718–726. doi: 10.1080/15563650.2018.1549735.
• Lao, Yvonne Elisabeth; Pham, Bich Diep; Le, Huong; Nguyen Van, Hien & Hovda, Knut Erik (2019). Methanol content in homemade alcohol from a province in North Vietnam. Drug and Alcohol Review. ISSN 0959-5236. 38(5), p. 537–542. doi: 10.1111/dar.12937.
• Syse, Victoria Lykke; Brekke, Mette; Grimsrud, Marit Mæhle; Persett, Per Sverre; Heyerdahl, Fridtjof & Hovda, Knut Erik [Show all 7 contributors for this article] (2019). Gender differences in acute recreational drug toxicity: a case series from Oslo, Norway. BMC Emergency Medicine. ISSN 1471-227X. 19(1). doi: 10.1186/s12873-019-0244-3. Full text in Research Archive Show summary

  Background Female drug users report poorer physical and mental health than male drug users. We describe female and male patients treated for acute recreational drug toxicity, and look for gender differences in clinical state, treatment, and toxic agents taken. Methods Retrospective case series from a primary care emergency outpatient clinic and a hospital emergency department in Oslo, Norway. All patients treated for acute recreational drug toxicity from October 2013 through March 2015 were included, except patients with lone alcohol intoxication. Patients were grouped according to whether they had taken opioids or not, as a proxy differentiation between heavy drug users and party drug users. Data from the two clinical settings were analysed separately. Results In total, 2495 cases were included, 567 (22.7%) were women. Female patients were younger than males, median 31 vs 34 years (p < 0.001). On most comparisons of clinical variables there were no significant differences between genders. A larger proportion of females in the outpatient opioid group were hypotensive, 10.9% vs 3.9% (p < 0.001). Fewer females were intubated, none vs 21.1% (p = 0.019) in the hospital opioid group, and 6.4% vs 21.0% (p = 0.039) in the hospital non-opioid group. The proportion of gamma-hydroxybutyrate (GHB) poisoning was larger among females both at the outpatient clinic (14.4% vs 8.6%, p < 0.001) and at the hospital (60.3% vs 36.4%, p = 0.001), while the proportion of heroin poisoning was smaller among females at the outpatient clinic (37.1% vs 47.0%, p < 0.001). Conclusion One in four patients treated for acute recreational drug toxicity were women. Female patients were younger, had more frequently taken GHB and were less frequently intubated. Otherwise, the gender differences regarding clinical state and treatment were small. Although female drug users are known to report poorer health than males, we did not find that women had a more severe clinical course than men when presenting with overdose.

• Yamamoto, Takahiro; Dargan, Paul Ivor; Dines, Alison M.; Yates, Christopher B.; Heyerdahl, Fridtjof & Hovda, Knut Erik [Show all 31 contributors for this article] (2018). Concurrent Use of Benzodiazepine by Heroin Users—What Are the Prevalence and the Risks Associated with This Pattern of Use? Journal of Medical Toxicology. ISSN 1556-9039. 15(1), p. 4–11. doi: 10.1007/s13181-018-0674-4.
• Lyphout, Cathelijne; Yates, Christopher B.; Margolin, Zachary R.; Dargan, Paul Ivor; Dines, Alison M. & Heyerdahl, Fridtjof [Show all 11 contributors for this article] (2018). Presentations to the emergency department with non-medical use of benzodiazepines and Z-drugs: profiling and relation to sales data. European Journal of Clinical Pharmacology. ISSN 0031-6970. 75(1), p. 77–85. doi: 10.1007/s00228-018-2550-1.
• Liakoni, Evangelia; Yates, Christopher; Dines, Alison M.; Dargan, Paul I; Heyerdahl, Fridtjof & Hovda, Knut Erik [Show all 9 contributors for this article] (2018). Acute recreational drug toxicity: Comparison of self-reports and results of immunoassay and additional analytical methods in a multicenter European case series. Medicine. ISSN 0025-7974. 97(5), p. 1–7. doi: 10.1097/MD.0000000000009784.
• Miro, Oscar; Yates, Christopher; Dines, Alison M.; Wood, David M.; Dargan, Paul I. & Galan, Itxaso [Show all 26 contributors for this article] (2018). Emergencies related to recreational drug abuse in Spain compared to emergencies attended in 3 European areas. Emergencias. ISSN 1137-6821. 30, p. 385–394.
• Drangsholt, Elise Rebekka; Vangstad, Marie; Zakharov, Sergey; Hovda, Knut Erik & Jacobsen, Dag (2018). The hypothesis of circulus hypoxicus and its clinical relevance in patients with methanol poisoning - An observational study of 35 patients. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 123(6), p. 749–755. doi: 10.1111/bcpt.13074.
• Zakharov, Sergey; Pelclová, Daniela; Navratil, Tomas; Běláček, Jaromír; Latta, Jiří & Pisar, Michal [Show all 23 contributors for this article] (2017). Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning. Clinical Toxicology. ISSN 1556-3650. 55(2), p. 123–132. doi: 10.1080/15563650.2016.1250901.
• Zakharov, Sergey; Rulisek, Jan; Nurieva, Olga; Kotikova, Katerina; Navrátil, Tomáš & Komarc, Martin [Show all 8 contributors for this article] (2017). Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks. Annals of Intensive Care. ISSN 2110-5820. 7:77, p. 1–11. doi: 10.1186/s13613-017-0300-7.
• Miro, Oscar; Galicia, Miguel; Dargan, Paul; Dines, Alison M.; Giraudon, Isabelle & Heyerdahl, Fridtjof [Show all 9 contributors for this article] (2017). Intoxication by gamma hydroxybutyrate and related analogues: Clinical characteristics and comparison between pure intoxication and that combined with other substances of abuse. Toxicology Letters. ISSN 0378-4274. 277, p. 84–91. doi: 10.1016/j.toxlet.2017.05.030.
• Vallersnes, Odd Martin; Persett, Per Sverre; Øiestad, Elisabeth Leere; Karinen, Ritva Anneli; Heyerdahl, Fridtjof & Hovda, Knut Erik (2017). Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway. Clinical Toxicology. ISSN 1556-3650. 55(7), p. 636–644. doi: 10.1080/15563650.2017.1312002. Full text in Research Archive
• Zakharov, Sergey; Pelclova, Daniela; Urban, Pavel; Navratil, Tomas; Nurieva, Olga & Kotikova, Katerina [Show all 12 contributors for this article] (2016). Use of Out-of-Hospital Ethanol Administration to Improve Outcome in Mass Methanol Outbreaks. Annals of Emergency Medicine. ISSN 0196-0644. 68(1), p. 52–61. doi: 10.1016/j.annemergmed.2016.01.010.
• Vallersnes, Odd Martin; Dines, Alison M.; Wood, David M.; Yates, Christopher; Heyerdahl, Fridtjof & Hovda, Knut Erik [Show all 8 contributors for this article] (2016). Psychosis associated with acute recreational drug toxicity: a European case series. BMC Psychiatry. ISSN 1471-244X. 16:293, p. 1–8. doi: 10.1186/s12888-016-1002-7. Full text in Research Archive
• Wood, David M.; Dines, Alison M.; Heyerdahl, Fridtjof; Yates, Christopher; Giraudon, Isabelle & Paasma, Raido [Show all 8 contributors for this article] (2016). Review of European-Drug Emergencies Network (Euro-DEN) training package for non-specialist workers to assess acute recreational drug and new psychoactive substance toxicity in night-time economy environments. Drugs: education prevention and policy. ISSN 0968-7637. 23(1), p. 73–77. doi: 10.3109/09687637.2015.1081379.
• Rostrup, Morten; Edwards, Jeffrey K.; Abukalish, Mohamed; Ezzabi, Masoud; Some, David & Ritter, Helga [Show all 13 contributors for this article] (2016). The methanol poisoning outbreaks in Libya 2013 and Kenya 2014. PLOS ONE. ISSN 1932-6203. 11(3). doi: 10.1371/journal.pone.0152676.
• McMartin, Kenneth E.; Jacobsen, Dag & Hovda, Knut Erik (2016). Antidotes for poisoning by alcohols that form toxic metabolites. British Journal of Clinical Pharmacology. ISSN 0306-5251. 81(3), p. 505–515. doi: 10.1111/bcp.12824.
• Dines, Alison M.; Woods, David; Galicia, Miguel; Yates, Christopher; Heyerdahl, Fridtjof & Hovda, Knut Erik [Show all 9 contributors for this article] (2015). Presentations to the emergency department following cannabis use - a multi-centre case series from ten European countries. Journal of Medical Toxicology. ISSN 1556-9039. 11(4), p. 415–421. doi: 10.1007/s13181-014-0460-x.
• Zakharov, Sergey; Pelclova, Daniela; Diblik, Pavel; Urban, Pavel; Kuthan, Pavel & Nurieva, Olga [Show all 20 contributors for this article] (2015). Long-term visual damage after acute methanol poisonings: Longitudinal cross-sectional study in 50 patients. Clinical Toxicology. ISSN 1556-3650. 53(9), p. 884–892. doi: 10.3109/15563650.2015.1086488.
• Dines, Alison M.; Wood, David M.; Yates, Christopher; Heyerdahl, Fridtjof; Hovda, Knut Erik & Giraudon, Isabelle [Show all 8 contributors for this article] (2015). Acute recreational drug and new psychoactive substance toxicity in Europe: 12 months data collection from the European Drug Emergencies Network (Euro-DEN). Clinical Toxicology. ISSN 1556-3650. 53(9), p. 893–900. doi: 10.3109/15563650.2015.1088157.
• Dalaker, Vivian M; Vallersnes, Odd Martin; Fosshaug, Linn Elisabeth Lillerud; Andersson, Kirsti Svendsen & Hovda, Knut Erik (2015). En ung kvinne som drakk streptestreagens. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 135(22), p. 2067–2070. doi: 10.4045/tidsskr.15.0190.
• Hovda, Knut Erik; Gadeholt, Gaut; Evtodienko, Vladimir & Jacobsen, Dag (2015). A novel bedside diagnostic test for methanol poisoning using dry chemistry for formate. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 75(7), p. 610–614. doi: 10.3109/00365513.2015.1066847.
• Zakharov, Sergey; Pelclova, Daniela; Navratil, Tomas; Belacek, Jaromir; Komarc, Martin & Eddleston, Michael [Show all 7 contributors for this article] (2015). Fomepizole versus ethanol in the treatment of acute methanol poisoning: Comparison of clinical effectiveness in a mass poisoning outbreak. Clinical Toxicology. ISSN 1556-3650. 53(8), p. 797–806. doi: 10.3109/15563650.2015.1059946.
• Zakharov, Sergey; Pelclova, Daniela; Urban, Pavel; Navratil, Tomas; Diblik, Pavel & Kuthan, Pavel [Show all 20 contributors for this article] (2014). Czech mass methanol outbreak 2012: Epidemiology, challenges and clinical features. Clinical Toxicology. ISSN 1556-3650. 52(10), p. 1013–1024. doi: 10.3109/15563650.2014.974106.
• Heyerdahl, Fridtjof; Hovda, Knut Erik; Giraudon, Isabelle; Yates, Christopher; Dines, Alison M. & Sedefov, Roumen [Show all 8 contributors for this article] (2014). Current European data collection on emergency department presentations with acute recreational drug toxicity: Gaps and national variations. Clinical Toxicology. ISSN 1556-3650. 52(10), p. 1005–1012. doi: 10.3109/15563650.2014.976792.
• Zakharov, Sergey; Pelclova, Daniela; Navratil, Tomas; Belacek, Jaromir; Kurcova, Ivana & Komzak, Ondrej [Show all 16 contributors for this article] (2014). Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning. Kidney International. ISSN 0085-2538. 86(1), p. 199–207. doi: 10.1038/ki.2014.60.
• Lund, Cathrine; Bjørnaas, Mari Asphjell; Sandvik, Leiv; Ekeberg, Øivind; Jacobsen, Dag & Hovda, Knut Erik (2013). Five-year mortality after acute poisoning treated in ambulances, an Emergency outpatient clinic and hospitals in Oslo. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. ISSN 1757-7241. 21:65. doi: 10.1186/1757-7241-21-65.
• Krayeva, Yulia V.; Brusin, Konstantin M.; Bushuev, Alexander V.; Kondrashov, Dimitry L.; Sentsov, Valentin G. & Hovda, Knut Erik (2013). Pre-hospital management and outcome of acute poisonings by ambulances in Yekaterinburg, Russia. Clinical Toxicology. ISSN 1556-3650. 51(8), p. 752–760. doi: 10.3109/15563650.2013.827707.
• Paasma, Raido; Hovda, Knut Erik; Hassanian-Moghaddam, Hossein; Brahmi, Nozha; Afshari, Reza & Sandvik, Leiv [Show all 7 contributors for this article] (2012). Risk factors related to poor outcome after methanol poisoning and the relation between outcome and antidotes - a multicenter study. Clinical Toxicology. ISSN 1556-3650. 50(9), p. 823–831. doi: 10.3109/15563650.2012.728224.
• Lund, Cathrine; Teige, Brita; Drottning, Per; Stiksrud, Birgitte; Rui, Tor Olav & Lyngra, Marianne [Show all 9 contributors for this article] (2012). A one-year observational study of all hospitalized and fatal acute poisonings in Oslo: Epidemiology, intention and follow-up. BMC Public Health. ISSN 1471-2458. 12(1). doi: 10.1186/1471-2458-12-858.
• Lund, Cathrine; Drottning, Per; Stiksrud, Birgitte; Vahabi, Javad; Lyngra, Marianne & Ekeberg, Ivind [Show all 8 contributors for this article] (2012). A one-year observational study of all hospitalized acute poisonings in Oslo: complications, treatment and sequelae. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. ISSN 1757-7241. 20(49). doi: 10.1186/1757-7241-20-49.
• Lund, Cathrine; Vallersnes, Odd Martin; Jacobsen, Dag; Ekeberg, Øivind & Hovda, Knut Erik (2012). Outpatient treatment of acute poisonings in Oslo : poisoning pattern, factors associated with hospitalization, and mortality. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. ISSN 1757-7241. 20. doi: 10.1186/1757-7241-20-1. Full text in Research Archive
• Kolvik, Hallgeir; Bjørnaas, Mari Asphjell; Hovda, Knut Erik; Jacobsen, Dag; Ekeberg, Øivind & Heyerdahl, Fridtjof (2011). Levekår og forgiftningsmønster i Oslos bydeler. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 131, p. 1424–1428. doi: 10.4045/tidsskr.10.0531.
• Hovda, Knut Erik; Julsrud, Joar; Øvrebø, Steinar; Brørs, Odd & Jacobsen, Dag (2011). Studies on ethylene glycol poisoning: One patient - 154 admissions. Clinical Toxicology. ISSN 1556-3650. 49(6), p. 478–484. doi: 10.3109/15563650.2011.590140. Show summary

  Objective. Fomepizole is the antidote of choice in toxic alcohol poisonings. Potential side effects from frequent use of fomepizole were studied in a patient admitted 154 times with ethylene glycol (EG) poisoning. The intra-individual correlation between the serum-ethylene glycol (serum-EG) and the osmolal gap (OG) EG-kinetics, and other laboratory parameters were also studied. Methods. Combined pro- and retrospective collection of material from three different hospitals, and results from autopsy. Results. A 26-year-old female with a dissociative disorder was admitted with EG poisoning a total of 154 times. Her admission data revealed a median pH of 7.31 (range 6.87–7.49), pCO2: 4.2 kPa (1.2–6.7) (32 mmHg [9–50]), HCO–3: 15 mmol/L (4–26) (15 mEq/L [4–26]), base deficit (BD): 10 mmol/L (− 4 to 27) (10 mEq/L [–4 to 27]), serum-creatinine 65 μmol/L (40–133) (0.74 mg/dL [0.45–1.51]), OG 81 mOsm/kgH2O (25–132), and serum-EG 44 mmol/L (4–112) (250 mg/dL [25–700]). She was treated with fomepizole 99 times, ethanol 60 times (with a combination of both six times), and dialysis 73 times. The correlation between serum-EG and OG was good (r2 = 0.76). She was finally found dead outside hospital with an EG blood concentration of 81 mmol/L (506 mg/dL). An autopsy revealed calcium oxalate crystals in the kidneys, slight liver steatosis, and slight edema of the lungs. Discussion. The frequent use of fomepizole in this young patient was not associated with any detectable side effects; neither on clinical examination and lab screening, nor on the later autopsy. Regarding the sequelae from the repetitive EG-poisoning episodes, her kidney function seemed to normalize after each overdose. She was treated with buffer and antidote without hemodialysis 81 times without complications, supporting the safety of this approach in selected cases.

• Hovda, Knut Erik; Guo, Chungang; Austin, Ronald & McMartin, Kenneth E. (2010). Renal toxicity of ethylene glycol results from internalization of calcium oxalate crystals by proximal tubule cells. Toxicology Letters. ISSN 0378-4274. 192(3), p. 365–372. doi: 10.1016/j.toxlet.2009.11.013.
• Bjørnaas, Mari Asphjell; Teige, Brita; Hovda, Knut Erik; Ekeberg, Øivind; Heyerdahl, Fridtjof & Jacobsen, Dag (2010). Fatal poisonings in Oslo: A one-year observational study. BMC Emergency Medicine. ISSN 1471-227X. 10(6), p. 10–13. doi: 10.1186/1471-227X-10-13.
• Bjørnaas, Mari Asphjell; Hovda, Knut Erik; Heyerdahl, Fridtjof; Skog, Karina; Drottning, Per & Opdahl, Anders [Show all 8 contributors for this article] (2010). Suicidal intention, psychosocial factors and referral to further treatment: A one-year cross-sectional study of self-poisoning. BMC Psychiatry. ISSN 1471-244X. 10. doi: 10.1186/1471-244X-10-58.
• Heyerdahl, Fridtjof; Bjørnaas, Mari Asphjell; Dahl, Rune; Hovda, Knut Erik; Nore, AK & Ekeberg, Øivind [Show all 7 contributors for this article] (2009). Repetition of acute poisoning in Oslo: 1-year prospective study. British Journal of Psychiatry. ISSN 0007-1250. 194(1), p. 73–79. doi: 10.1192/bjp.bp.107.048322.
• Hovda, Knut Erik; Bjørnaas, Mari Asphjell; Skog, Karina; Opdahl, Anders; Drottning, P & Ekeberg, Øivind [Show all 7 contributors for this article] (2008). Acute poisonings treated in hospitals in Oslo: A one-year prospective study (I): Pattern of poisoning. Clinical Toxicology. ISSN 1556-3650. 46(1), p. 35–41. doi: 10.1080/15563650601185969. Show summary

  Objectives. Prospective design is mandatory to study pattern of poisoning and suicidal intention of patients. Material and Methods. Prospective cross-sectional multi-center study of all patients contacting health care services because of acute poisoning during one year in Oslo, irrespective of intention. Data on the adult hospitalized patients (>/=16 years) are presented here. Results. Of a total of 3,775 such adult contacts (3,025 episodes), there were 947 (31 %) hospitalizations; annual incidence 1.9 (per 1,000) in males and 2.1 in females. Median age was 36 years (range 16-89); 54% females. Benzodiazepines (18%), ethanol (17%), paracetamol (12%), opioids (7%), and gamma hydroxybutyric acid (GHB) (7%) were most frequently taken. Patients stated suicidal intention in 29% of the admissions; physicians in 10%. Conclusion. Benzodiazepines and ethanol were the most common agents, but newer illicit drugs were frequent, especially GHB. Males often took ethanol and drugs of abuse; females often used prescription drugs with suicidal intention

• Heyerdahl, Fridtjof; Bjørnaas, Mari Asphjell; Hovda, Knut Erik; Skog, Karina; Opdahl, Anders & Wium, Cecilie [Show all 8 contributors for this article] (2008). Acute poisonings treated in hospitals in Oslo: A one-year prospective study (II): Clinical outcome. Clinical Toxicology. ISSN 1556-3650. 46(1), p. 42–49. doi: 10.1080/15563650701210048. Show summary

  Objectives. The changing pattern of acute poisoning may affect complications and outcome in these patients. An update study on acute poisonings was therefore performed and compared to similar data from 1980. Design. A prospective cross-sectional multi-center study of all adult patients ( 16 years) hospitalized in Oslo with a main diagnosis of acute poisoning, irrespective of intention, over a one-year period. Results. Of 947 admissions, 222 (23%) were comatose. Complications were observed in 173 (18%), slightly reduced from 1980 (22%). Ten (1.1%) died and six (0.6%) got permanent sequelae, of which seven and five were drug- or alcohol-related, respectively. Seventy-five percent received treatment besides observation; 39% received antidotes, increased from 21% in 1980, most frequently flumazenil (23%) and naloxone (14%). Conclusions. In-hospital mortality in poisoned patients remained low, few patients entailed complications, and most patients survived without permanent sequelae. Drug- and alcohol-abuse related poisonings were most severe

• Heyerdahl, Fridtjof; Hovda, Knut Erik; Bjørnaas, Mari Asphjell; Brørs, Odd; Ekeberg, Ole Marius & Jacobsen, Dag (2008). Clinical assessment compared to laboratory screening in acutely poisoned patients. Human and Experimental Toxicology. ISSN 0960-3271. 27. doi: 10.1177/0960327107087800.
• Rajka, Thomas; Heyerdahl, Fridtjof; Hovda, Knut Erik; Stiksrud, Birgitte & Jacobsen, Dag (2007). Acute child poisonings in Oslo. Acta Paediatrica. ISSN 0803-5253. 96(9), p. 1355–1359. doi: 10.1111/j.1651-2227.2007.00420.x.

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• Wood, David M.; Dines, Alison M.; Liechti, Matthias E.; Giraudon, Isabelle; Heyerdahl, Fridtjof & hovda, knut erik [Show all 10 contributors for this article] (2023). Diphenidine, methoxyphenidine and related 1,2-diarylethylamine acute toxicity reported to the Euro-DEN Plus project.
• Waters, Mitchell; Wood, David M.; Yates, Christopher; Dines, Alison M.; Giraudon, Isabelle & Liechti, Matthias E. [Show all 11 contributors for this article] (2022). Clinical effects of cannabis compared to synthetic cannabinoids (SCs): a retrospective cohort study.
• Hovda, Knut Erik; Lao, Yvonne Elisabeth; Gadeholt, Gaut & Jacobsen, Dag (2021). Formate test for bedside diagnosis of methanol poisoning. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 129(1), p. 86–88. doi: 10.1111/bcpt.13597.
• Slørdahl, Johannes Thomassen; Persett, Per Sverre; Brekke, Mette; Heyerdahl, Fridtjof; Hovda, Knut Erik & Vallersnes, Odd Martin (2021). Acute poisoning from concurrent use of opioids and amphetamine.
• Hassanian-Moghaddam, Hossein; Zamani, Nasim; Kolahi, Ali-Asghar; McDonald, Rebecca & Hovda, Knut Erik (2020). Double trouble: Methanol outbreak in the wake of the COVID-19 pandemic in Iran - A cross-sectional assessment. Critical Care. ISSN 1364-8535. 24(1). doi: 10.1186/s13054-020-03140-w.
• Gundem, Trine; Olasveengen, Theresa M.; Schøndorf, Christina Luise; Hovda, Knut Erik; Rostrup, Morten & Frøyshov, Sten [Show all 11 contributors for this article] (2020). T.M. Gundem og medarbeidere svarer. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(12), p. 1–2. doi: 10.4045/tidsskr.20.0650. Full text in Research Archive
• Vallersnes, Odd Martin; Dines, Alison M.; Wood, David M.; Heyerdahl, Fridtjof; Hovda, Knut Erik & Yates, Christopher [Show all 8 contributors for this article] (2020). Self-discharge during treatment for acute recreational drug toxicity: an analysis of four-years of Euro-DEN Plus presentations.
• Syse, Victoria Lykke; Brekke, Mette; Grimsrud, Marit Mæhle; Persett, Per Sverre; Heyerdahl, Fridtjof & Hovda, Knut Erik [Show all 7 contributors for this article] (2019). Acute recreational drug toxicity in women: a case series from Oslo, Norway.
• Zakharov, Sergey; Roberts, Darren M. & Hovda, Knut Erik (2017). Reply to “Letter in response to efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning”. Clinical Toxicology. ISSN 1556-3650. 55(4), p. 306–307. doi: 10.1080/15563650.2017.1284338.
• Vallersnes, Odd Martin; Dines, Alison M.; Wood, David M.; Yates, Christopher; Heyerdahl, Fridtjof & hovda, knut erik [Show all 8 contributors for this article] (2016). Erratum to: Psychosis associated with acute recreational drug toxicity: A European case series [BMC Psychiatry, 16 (2016), (293)], DOI:10.1186/s12888-016-1002-7. BMC Psychiatry. ISSN 1471-244X. 16(1). doi: 10.1186/s12888-016-1066-4.
• Paasma, Raido; Tönisson, Mailis; Føreid, Siri; Gadeholt, Gaut & Hovda, Knut Erik (2016). Methanol and formate concentrations in brain after methanol poisining.
• Hovda, Knut Erik; Gadeholt, Gaut & Jacobsen, Dag (2016). Ethanol strips for monitoring of ethanol concentrations during treatment of toxic alkohol: preliminary results.
• Øiestad, Elisabeth Leere; Nordfjærn, Trond; Edland-Gryt, Marit; Bretteville-Jensen, Anne Line; Hovda, Knut Erik & Persett, Per Sverre [Show all 9 contributors for this article] (2015). Use of oral fluid for analysis of new psychoactive substances.
• Dalaker, Vivian; Vallersnes, Odd Martin; Fosshaug, Linn E; Andersson, Kirsti Svendsen & Hovda, Knut Erik (2015). Drinking strep test reagents: a case of nitrite poisoning.
• Persett, Per Sverre; Vallersnes, Odd Martin; Øiestad, Elisabeth Leere; Karinen, Ritva Anneli; Bogstrand, Stig Tore & Heyerdahl, Fridtjof [Show all 7 contributors for this article] (2015). Laboratory confirmation of recreational drugs in Oslo, Norway.
• Vallersnes, Odd Martin; Dines, Alison M.; Wood, David M.; Yates, Christopher; Heyerdahl, Fridtjof & Hovda, Knut Erik [Show all 9 contributors for this article] (2015). Psychosis associated with acute poisoning by recreational drugs: a European case series.
• Lund, Caroline; Hovda, Knut Erik; Gudmundsdottir, Helga; Andersson, Kirsti Svendsen; NYVOLD, CECILIE & Froyshov, Sten [Show all 8 contributors for this article] (2013). Severe metformin-induced lactic acidosis: Case series of 10 patients. Clinical Toxicology. ISSN 1556-3650. 51(4), p. 365–365.
• Pelclova, Daniela; Zakharov, Sergej; Navratil, Tomas & Hovda, Knut Erik (2013). Methanol outbreak in the Czech Republic in 2012: Epidemiology and clinical features. Clinical Toxicology. ISSN 1556-3650. 51(4), p. 252–253.
• Paasma, Raido; Hovda, Knut Erik; Hassanian-Moghaddan, H; Brahmi, Nozha; Afshari, Reza & Sandvik, Leiv [Show all 7 contributors for this article] (2013). Response to the letter "Risk assessment of methanol poisoning in outbreaks not applicable to isolated cases". Clinical Toxicology. ISSN 1556-3650. 51(2), p. 120–120. doi: 10.3109/15563650.2013.764430.
• Hovda, Knut Erik (2013). Formate analysis as a simple methanol diagnostic approach: The cost-beneficial answer for evaluating metabolic acidosis. Clinical Toxicology. ISSN 1556-3650. 51(4), p. 298–298.
• Hovda, Knut Erik; Refsum, Helge & Jacobsen, Dag (2012). A Case of Extraordinary High Serum-Venlafaxine and Prolonged Elimination without Genetic Predisposal. Clinical Toxicology. ISSN 1556-3650. 50(4), p. 324–325.
• Paasma, Raido; Hovda, Knut Erik; Hassanian-Moghaddan, H; Brahmi, Nozha; Afshari, Reza & Jacobsen, Dag (2012). Risk Assessment Score for Methanol Poisoning. Clinical Toxicology. ISSN 1556-3650. 50(4), p. 350–351.
• Lund, Cathrine; Vallersnes, Odd Martin; Jacobsen, Dag; Ekeberg, Øivind & Hovda, Knut Erik (2011). Acute poisonings treated at the outpatient accident and emergency clinic (EMA) in Oslo, 2008.
• Hovda, Knut Erik (2010). Formate Analyses: A Research Tool of Limited Interest, or a Diagnostic Tool in the Clinical Setting? Clinical Toxicology. ISSN 1556-3650. 48(3), p. 267–268.
• Bjornaas, MA; Bjørnaas, Mari Asphjell; Teige, Brita; Hovda, KE; Heyerdahl, F & Ekeberg, O [Show all 7 contributors for this article] (2009). Deaths by self-poisoning in Oslo and the surrounding area during one year. Clinical Toxicology. ISSN 1556-3650. 47(5), p. 504–505.
• Heyerdahl, Fridtjof; Bjørnaas, Mari Asphjell; Dahl, R.; Hovda, Knut Erik; Ekeberg, Øivind & Jacobsen, Dag (2007). Repetition of acute poisonings in Oslo: a one year prospective study.
• Heyerdahl, Fridtjof; Hovda, Knut Erik; Bjørnaas, Mari Asphjell; Ekeberg, Øivind & Jacobsen, Dag (2007). Forgiftninger ved sykehusene i Oslo.
• Heyerdahl, Fridtjof; Bjørnaas, Mari Asphjell; Dahl, R; Hovda, Knut Erik; Ekeberg, Øivind & Jacobsen, Dag (2007). Repetition of acute poisonings in Oslo. A one year prospective study.
• Heyerdahl, Fridtjof; Bjørnaas, Mari Asphjell; Hovda, Knut Erik; Ekeberg, Øivind & Jacobsen, Dag (2007). Different levels of care for poisoned patients in Oslo. A one year prospective study.
• Bjørnaas, Mari Asphjell; Hovda, Knut Erik; Heyerdahl, Fridtjof; Ekeberg, Øivind; Skog, K & Drottning, P [Show all 8 contributors for this article] (2006). Differences in suicidal intention, background and aftercare among patients treated for self-poisonings – a one year prospective study from Oslo. Psychiatria Danubina. ISSN 0353-5053. 18, p. 87–87.
• Heyerdahl, Fridtjof; Hovda, Knut Erik; Bjørnaas, Mari Asphjell; Ekeberg, Øivind & Jacobsen, Dag (2006). Clinical versus laboratory findings in the diagnosis of acute poisoning. Clinical Toxicology. ISSN 1556-3650. 44(4), p. 408–409.
• Heyerdahl, Fridtjof; Hovda, Knut Erik; Bjørnaas, Mari Asphjell; Ekeberg, Øivind & Jacobsen, Dag (2006). Clinical versus laboratory findings in the diagnosis of acute poisoning.

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