Knut Husø Lauritzen

• Olsen, Maria Belland; Kong, Xiang Yi; Louwe, Maria; Lauritzen, Knut Husø; Schanke, Ylva & Kaasbøll, Ole Jørgen [Show all 14 contributors for this article] (2024). SLAMF1-derived peptide exhibits cardio protection after permanent left anterior descending artery ligation in mice. Frontiers in Immunology. ISSN 1664-3224. 15. doi: 10.3389/fimmu.2024.1383505.
• Gregersen, Ida; Kong, Xiang Yi; Kooijman, Sander; Foyn, Håvard; Grannes, Helene & Olsen, Maria Belland [Show all 25 contributors for this article] (2024). T cells with increased responsiveness cause obesity in mice without diet intervention. iScience. ISSN 2589-0042. 27(4). doi: 10.1016/j.isci.2024.109471.
• Kong, Xiang Yi; Lauritzen, Knut Husø; Dahl, Tuva Børresdatter; Holm, Sverre; Olsen, Maria Belland & Skjelland, Mona [Show all 12 contributors for this article] (2024). CD38 deficient mice are not protected from atherosclerosis. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 705. doi: 10.1016/j.bbrc.2024.149734.
• Roman, Giacomo; Stavik, Benedicte; Lauritzen, Knut Husø; Sandset, Per Morten; Harrison, Sean & Sullivan, Gareth John [Show all 7 contributors for this article] (2023). “iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives”. Frontiers in Physiology. ISSN 1664-042X. 14. doi: 10.3389/fphys.2023.1094249. Full text in Research Archive
• Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi & Yang, Kuan [Show all 30 contributors for this article] (2021). DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. Atherosclerosis. ISSN 0021-9150. 324, p. 123–132. doi: 10.1016/j.atherosclerosis.2021.02.023. Full text in Research Archive
• Lauritzen, Knut H.; Olsen, Maria Belland; Ahmed, Mohammed Shakil; Yang, Kuan; Rinholm, Johanne Egge & Bergersen, Linda H. [Show all 13 contributors for this article] (2021). Instability in nad+ metabolism leads to impaired cardiac mitochondrial function and communication. eLIFE. ISSN 2050-084X. 10, p. 1–23. doi: 10.7554/ELIFE.59828. Full text in Research Archive
• Ormel, Lasse; Lauritzen, Knut Husø; Schreiber, Rainer; Kunzelmann, Karl & Gundersen, Vidar (2020). GABA, but not bestrophin-1, is localized in astroglial processes in the mouse hippocampus and the cerebellum. Frontiers in Molecular Neuroscience. ISSN 1662-5099. 13, p. 1–13. doi: 10.3389/fnmol.2020.00135. Full text in Research Archive
• Guardia-Laguarta, C; Liu, Yuhui; Lauritzen, Knut Husø; Erdjument-Bromage, Hediye; Martin, B & Swayne, T C [Show all 8 contributors for this article] (2019). PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation. Journal of Neuroscience. ISSN 0270-6474. 39(36), p. 7074–7085. doi: 10.1523/JNEUROSCI.1691-18.2019. Full text in Research Archive
• Yang, Kuan; Lauritzen, Knut Husø; Olsen, Maria Belland; Dahl, Tuva Børresdatter; Ranheim, Trine & Ahmed, Muhammad Shakil [Show all 12 contributors for this article] (2019). Low cellular NAD+ compromises lipopolysaccharide-induced inflammatory responses via inhibiting TLR4 signal transduction in human monocytes. Journal of Immunology. ISSN 0022-1767. 203(6), p. 1598–1608. doi: 10.4049/jimmunol.1801382.
• Torp, May-Kristin; Yang, Kuan; Ranheim, Trine; Lauritzen, Knut Husø; Alfsnes, Katrine & Vinge, Leif Erik [Show all 10 contributors for this article] (2019). Mammalian target of rapamycin (mTOR) and the proteasome attenuates IL-1β expression in primary mouse cardiac fibroblasts. Frontiers in Immunology. ISSN 1664-3224. 10. doi: 10.3389/fimmu.2019.01285. Full text in Research Archive
• Hasan-Olive, Md Mahdi; Lauritzen, Knut Husø; Ali, Mohammad Abdulla; Rasmussen, Lene Juel; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2018). A ketogenic diet improves mitochondrial biogenesis and bioenergetics via the PGC1α-SIRT3-UCP2 axis. Neurochemical Research. ISSN 0364-3190. p. 1–16. doi: 10.1007/s11064-018-2588-6.
• Lauritzen, Knut Husø; Hasan-Olive, Md Mahdi; Regnell, Christine E; Kleppa, Liv; Scheibye Knudsen, Morten & Gjedde, Albert [Show all 10 contributors for this article] (2016). A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. Neurobiology of Aging. ISSN 0197-4580. 48, p. 34–47. doi: 10.1016/j.neurobiolaging.2016.08.005.
• Lauritzen, Knut Husø; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald & Haugen, Øyvind Pernell [Show all 12 contributors for this article] (2015). Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 309(3), p. H434–H449. doi: 10.1152/ajpheart.00253.2014.
• Morland, Cecilie; Lauritzen, Knut Husø; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Andersson, Krister & Gjedde, Albert [Show all 9 contributors for this article] (2015). The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain. Journal of Neuroscience Research. ISSN 0360-4012. 93(7), p. 1045–1055. doi: 10.1002/jnr.23593.
• Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn & Lauritzen, Fredrik [Show all 10 contributors for this article] (2014). Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism. Cereb Cortex. Cerebral Cortex. ISSN 1047-3211. p. 2784–2795. doi: 10.1093/cercor/bht136.
• Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn & Lauritzen, Fredrik [Show all 10 contributors for this article] (2013). Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism. Cerebral Cortex. ISSN 1047-3211. doi: 10.1093/cercor/bht136. Show summary

  The G-protein-coupled lactate receptor, GPR81 (HCA1), is known to promote lipid storage in adipocytes by downregulating cAMP levels. Here, we show that GPR81 is also present in the mammalian brain, including regions of the cerebral neocortex and hippocampus, where it can be activated by physiological concentrations of lactate and by the specific GPR81 agonist 3,5-dihydroxybenzoate to reduce cAMP. Cerebral GPR81 is concentrated on the synaptic membranes of excitatory synapses, with a postsynaptic predominance. GPR81 is also enriched at the blood-brain-barrier: the GPR81 densities at endothelial cell membranes are about twice the GPR81 density at membranes of perivascular astrocytic processes, but about one-seventh of that on synaptic membranes. There is only a slight signal in perisynaptic processes of astrocytes. In synaptic spines, as well as in adipocytes, GPR81 immunoreactivity is located on subplasmalemmal vesicular organelles, suggesting trafficking of the protein to and from the plasma membrane. The results indicate roles of lactate in brain signaling, including a neuronal glucose and glycogen saving response to the supply of lactate. We propose that lactate, through activation of GPR81 receptors, can act as a volume transmitter that links neuronal activity, cerebral energy metabolism and energy substrate availability.

• Chang, Cheng; Edin, Nina Frederike J; Lauritzen, Knut Husø; Aspmodal, Ida; Christoffersen, Stine & Jian, Liu [Show all 10 contributors for this article] (2012). Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cellular Oncology. ISSN 1570-5870. 35(3), p. 217–227. doi: 10.1007/s13402-012-0081-9.
• Lauritzen, Knut Husø; Dalhus, Bjørn; Storm, Johan Frederik; Bjørås, Magnar & Klungland, Arne (2011). Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond. Mechanisms of Ageing and Development. ISSN 0047-6374. 132(8-9), p. 424–428. doi: 10.1016/j.mad.2011.02.006.
• Lauritzen, Knut Husø; Chang, Cheng; Wiksén, Hege; Bergersen, Linda Hildegard & Klungland, Arne (2011). Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses. DNA Repair. ISSN 1568-7864. 10(6), p. 639–653. doi: 10.1016/j.dnarep.2011.04.011.
• Lauritzen, Knut Husø; Moldestad, Olve; Eide, Lars; Carlsen, Harald; Nesse, Gaute & Storm, Johan Frederik [Show all 9 contributors for this article] (2010). Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior. Molecular and Cellular Biology. ISSN 0270-7306. 30(6), p. 1357–1367. doi: 10.1128/MCB.01149-09. Show summary

  Mitochondrial dysfunction underlying changes in neurodegenerative diseases is often associated with apoptosis and a progressive loss of neurons, and damage to the mitochondrial genome is proposed to be involved in such pathologies. In the present study we designed a mouse model that allows us to specifically induce mitochondrial DNA toxicity in the forebrain neurons of adult mice. This is achieved by CaMKII-regulated inducible expression of a mutated version of the mitochondrial UNG DNA repair enzyme (mutUNG1). This enzyme is capable of removing thymine from the mitochondrial genome. We demonstrate that a continual generation of apyrimidinic sites causes apoptosis and neuronal death. These defects are associated with behavioral alterations characterized by increased locomotor activity, impaired cognitive abilities, and lack of anxietylike responses. In summary, whereas mitochondrial base substitution and deletions previously have been shown to correlate with premature and natural aging, respectively, we show that a high level of apyrimidinic sites lead to mitochondrial DNA cytotoxicity, which causes apoptosis, followed by neurodegeneration.

• Ringvoll, Jeanette; Ringvoll, Jeanette; Nordstrand, Line M.; Vågbø, Cathrine Broberg; Vagbo, CB & Talstad, Vivi [Show all 15 contributors for this article] (2006). Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO Journal. ISSN 0261-4189. 25, p. 2189–2198.

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• Roman, Giacomo; Lauritzen, Knut Husø; Harrison, Sean Philip; Sullivan, Gareth John; Iversen, Nina & Henriksson, Carola Elisabeth [Show all 10 contributors for this article] (2023). OC 07.1 Autologous CRISPR/Cas9 Correction of a Missense Variant from a Patient with Severe, Inherited FVII Deficiency. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. 7(Oral communications ISTH 2023). doi: 10.1016/j.rpth.2023.100475.
• Lauritzen, Knut Husø; Sullivan, Gareth John; Harrison, Sean Philip; Iversen, Nina; Henriksson, Carola Elisabeth & Glosli, Heidi [Show all 9 contributors for this article] (2023). OC 07.1 Autologous CRISPR/Cas9 Correction of a Missense Variant from a Patient with Severe, Inherited FVII Deficiency. Research and Practice in Thrombosis and Haemostasis (RPTH). ISSN 2475-0379. doi: 10.1016/j.rpth.2023.100475.
• Bergersen, Linda Hildegard; Lauritzen, Knut Husø; Lauritzen, Fredrik; Puchades, Maja Amedjkouh & Gjedde, Albert (2012). Lactate receptor locations link neurotransmission, neurovascular coupling, and brain energy metabolism. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 32, p. S183–S183.
• Lauritzen, Knut Husø (2011). Mitochondrial DNA damage in forebrain neurons of mice. Unipub forlag. ISSN 978-82-8264-151-7.

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