Kristian Folkvord Hanssen

• Krogvold, Lars; Mynarek, Ida Maria; Ponzi, Erica; Mørk, Freja Barrett; Hessel, Trine Witzner & Roald, Trine [Show all 14 contributors for this article] (2023). Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial. Nature Medicine. ISSN 1078-8956. 29(4). doi: 10.1038/s41591-023-02576-1. Full text in Research Archive
• Kelly, Clare B.; Karanchi, Harsha; Yu, Jeremy Y.; Leyva, Misti J.; Jenkins, Alicia J. & Nankervis, Alison J. [Show all 13 contributors for this article] (2023). Plasma AGE and Oxidation Products, Renal Function, and Preeclampsia in Pregnant Women with Type 1 Diabetes: A Prospective Observational Study. Journal of Diabetes Research. ISSN 2314-6745. 2023. doi: 10.1155/2023/8537693. Full text in Research Archive
• Sveen, Kari Anne; Holte, Kristine Bech; Svanteson, Mona; Hanssen, Kristian F.; Nilsson, Jan-Åke & Bengtsson, Eva [Show all 7 contributors for this article] (2021). Autoantibodies against methylglyoxal-modified apolipoprotein B100 and apob100 peptide are associated with less coronary artery atherosclerosis and retinopathy in long-term type 1 diabetes. Diabetes Care. ISSN 0149-5992. 44(6), p. 1402–1409. doi: 10.2337/dc20-2089.
• Kelly, Clare B.; Wagner, Carol L.; Shary, Judith R.; Leyva, Misti J.; Yu, Jeremy Y. & Jenkins, Alicia J. [Show all 13 contributors for this article] (2020). Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes. Nutrients. ISSN 2072-6643. 12(7), p. 1–12. doi: 10.3390/nu12072048. Full text in Research Archive
• Holte, Kristine Bech; Svanteson, Mona; Hanssen, Kristian Folkvord; Sveen, Kari Anne; Seljeflot, Ingebjørg & Solheim, Svein [Show all 9 contributors for this article] (2020). Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study. PLOS ONE. ISSN 1932-6203. doi: 10.1371/journal.pone.0233174. Full text in Research Archive
• Kelly, Clare B.; Yu, Jeremy Y.; Jenkins, Alica J.; Nankervis, Alison J.; Hanssen, Kristian Folkvord & Garg, Satish K. [Show all 11 contributors for this article] (2019). Haptoglobin Phenotype Modulates Lipoprotein-Associated Risk for Preeclampsia in Women With Type 1 Diabetes. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 104(10), p. 4743–4755. doi: 10.1210/jc.2019-00723.
• Holte, Kristine Bech; Svanteson, Mona; Hanssen, Kristian Folkvord; Haig, Ylva; Solheim, Svein & Berg, Tore Julsrud (2019). Undiagnosed coronary artery disease in long-term type 1 diabetes. The Dialong study. Journal of Diabetes and its Complications (JDC). ISSN 1056-8727. 33(5), p. 383–389. doi: 10.1016/j.jdiacomp.2019.01.006. Full text in Research Archive
• Heier, Martin; Nygaard, Cathrine Skorpen; Brunborg, Cathrine; Seljeflot, Ingebjørg; MARGEIRSDOTTIR, HANNA DIS & Hanssen, Kristian Folkvord [Show all 8 contributors for this article] (2018). Preserved endothelial function in young adults with type 1 diabetes. PLOS ONE. ISSN 1932-6203. 13:e0206523(10), p. 1–8. doi: 10.1371/journal.pone.0206523. Full text in Research Archive
• Kuric, Enida; Krogvold, Lars; Hanssen, Kristian Folkvord; Dahl-Jørgensen, Knut; Skog, Oskar & Korsgren, Olle (2018). No evidence for presence of mucosal-associated invariant T cells in the insulitic lesions in patients recently diagnosed with Type 1 diabetes. American Journal of Pathology. ISSN 0002-9440. 188(8), p. 1744–1748. doi: 10.1016/j.ajpath.2018.04.009.
• Kelly, Clare B.; Hookham, Michelle B.; Yu, Jeremy Y.; Jenkins, Alica J.; Nankervis, Alison J. & Hanssen, Kristian Folkvord [Show all 12 contributors for this article] (2018). Subclinical first trimester renal abnormalities are associated with preeclampsia in normoalbuminuric women with type 1 diabetes. Diabetes Care. ISSN 0149-5992. 41(1), p. 120–127. doi: 10.2337/dc17-1635.
• Holm, Laurits J.; Krogvold, Lars; Hasselby, Jane P.; Kaur, Simranjeet; Claessens, Laura A. & Russell, Mark A. [Show all 15 contributors for this article] (2018). Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia. ISSN 0012-186X. 61(7), p. 1650–1661. doi: 10.1007/s00125-018-4614-2. Full text in Research Archive
• Heier, Martin; Stensæth, Knut Haakon; Brunborg, Cathrine; Seljeflot, Ingebjørg; Margeirsdottir, Hanna Dis & Hanssen, Kristian Folkvord [Show all 7 contributors for this article] (2018). Increased arterial stiffness in childhood onset diabetes: A cardiovascular magnetic resonance study. European Heart Journal-Cardiovascular Imaging. ISSN 2047-2404. 19(6), p. 694–700. doi: 10.1093/ehjci/jex178.
• Kelly, Clare B.; Hookham, Michelle B.; Yu, Jeremy Y.; Lockhart, Samuel M.; Du, Mei & Jenkins, Alica J. [Show all 15 contributors for this article] (2017). Circulating adipokines are associated with pre-eclampsia in women with type 1 diabetes. Diabetologia. ISSN 0012-186X. 60(12), p. 2514–2524. doi: 10.1007/s00125-017-4415-z.
• Holte, Kristine Bech; Juel, Niels Gunnar; Brox, Jens Ivar; Hanssen, Kristian Folkvord; Fosmark, Dag Sigurd & Sell, David R. [Show all 8 contributors for this article] (2017). Hand, shoulder and back stiffness in long-term type 1 diabetes; cross-sectional association with skin collagen advanced glycation end-products. The Dialong study. Journal of Diabetes and its Complications (JDC). ISSN 1056-8727. 31(9), p. 1408–1414. doi: 10.1016/j.jdiacomp.2017.06.007.
• Heier, Martin; Borja, Mark S.; Brunborg, Cathrine; Seljeflot, Ingebjørg; MARGEIRSDOTTIR, HANNA DIS & Hanssen, Kristian Folkvord [Show all 8 contributors for this article] (2017). Reduced HDL function in children and young adults with type 1 diabetes. Cardiovascular Diabetology. ISSN 1475-2840. 16:85, p. 1–8. doi: 10.1186/s12933-017-0570-2. Full text in Research Archive
• Brunvand, Leif; Heier, Martin; Brunborg, Cathrine; Hanssen, Kristian Folkvord; Fugelseth, Drude & STENSÆTH, KNUT HAAKON [Show all 8 contributors for this article] (2017). Advanced glycation end products in children with type 1 diabetes and early reduced diastolic heart function. BMC Cardiovascular Disorders. ISSN 1471-2261. 17(133). doi: 10.1186/s12872-017-0551-0. Full text in Research Archive
• Kuric, Enida; Seiron, Peter; Krogvold, Lars; Edwin, Bjørn; Buanes, Trond & Hanssen, Kristian Folkvord [Show all 9 contributors for this article] (2017). Demonstration of tissue resident memory CD8 T cells in insulitic lesions in adult patients with recent-onset type 1 diabetes. American Journal of Pathology. ISSN 0002-9440. 187(3), p. 581–588. doi: 10.1016/j.ajpath.2016.11.002.
• Krogvold, Lars; Skog, Oskar; Sundström, Görel; Edwin, Bjørn; Buanes, Trond & Hanssen, Kristian Folkvord [Show all 10 contributors for this article] (2015). Function of isolated pancreatic islets from patients at onset of type 1 diabetes: Insulin secretion can be restored after some days in a nondiabetogenic environment in vitro results from the divid study. Diabetes. ISSN 0012-1797. 64(7), p. 2506–2512. doi: 10.2337/db14-1911.
• Krogvold, Lars; Wiberg, Anna; Edwin, Bjørn; Buanes, Trond; Jahnsen, Frode Lars & Hanssen, Kristian Folkvord [Show all 10 contributors for this article] (2015). Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes. Diabetologia. ISSN 0012-186X. 59(3), p. 492–501. doi: 10.1007/s00125-015-3820-4. Show summary

  Aims/hypothesis It is thought that T cells play a major role in the immune-mediated destruction of beta cells in type 1 diabetes, causing inflammation of the islets of Langerhans (insulitis). The significance of insulitis at the onset of type 1 diabetes is debated, and the role of the T cells poorly understood. Methods In the Diabetes Virus Detection (DiViD) study, pancreatic tissue from six living patients with recent-onset type 1 diabetes was collected. The insulitis was characterised quantitatively by counting CD3+ T cells, and qualitatively by transcriptome analysis targeting 84 T and B lymphocyte genes of laser-captured microdissected islets. The findings were compared with gene expression in T cells collected from kidney biopsies from allografts with ongoing cellular rejection. Cytokine and chemokine release from isolated islets was characterised and compared with that from islets from nondiabetic organ donors. Results All six patients fulfilled the criteria for insulitis (5–58% of the insulin-containing islets in the six patients had ≥15 T cells/islet). Of all the islets, 36% contained insulin, with several resembling completely normal islets. The majority (61– 83%) of T cells were found as peri-insulitis rather than within the islet parenchyma. The expression pattern of T cell genes was found to be markedly different in islets compared with the rejected kidneys. The islet-infiltrating T cells showed only background levels of cytokine/chemokine release in vitro. Conclusions/interpretation Insulitis and a significant reserve reservoir for insulin production were present in all six cases of recent-onset type 1 diabetes. Furthermore, the expression patterns and levels of cytokines argue for a different role of the T cells in type 1 diabetes when compared with allograft rejection.

• Heier, Martin; MARGEIRSDOTTIR, HANNA DIS; Gaarder, Mario; STENSÆTH, KNUT-HAAKON; Brunborg, Cathrine & Torjesen, Peter A [Show all 9 contributors for this article] (2015). Soluble RAGE and atherosclerosis in youth with type 1 diabetes: A 5-year follow-up study. Cardiovascular Diabetology. ISSN 1475-2840. 14(126). doi: 10.1186/s12933-015-0292-2. Show summary

  Background: Advanced glycation end products (AGEs) play a role in the development of late complications and ath‑ erosclerosis in diabetes by engaging the receptor for advanced glycation end products, RAGE. Receptor binding leads to activation of the vascular endothelium and increased inflammation in the vessel wall. The soluble variants of the receptor, endogenous secretory RAGE (esRAGE) and the cleaved cell ‑ surface part of RAGE, which together comprise soluble RAGE (sRAGE), are suggested to have a protective effect acting as decoys for RAGE. We aimed to test whether high levels of soluble variants of RAGE could be protective against atherosclerosis development. Methods: Participants in the prospective atherosclerosis and childhood diabetes study were examined at baseline (aged 8–18) and at follow ‑ up after 5 years. Both sRAGE and esRAGE were measured by immunoassay in 299 patients with type 1 diabetes and 112 healthy controls at baseline and 241 patients and 128 controls at follow ‑ up. The AGEs methylglyoxal ‑ derived hydroimidazolone ‑ 1 (MG ‑ H1) and carboxymethyllysine (CML) were measured by immunoas‑ say. The surrogate markers of atherosclerosis assessed were carotid intima ‑ media thickness (cIMT ), C ‑ reactive protein (CRP) and Young’s modulus, measures of arterial wall thickness, inflammation and arterial stiffness, respectively. Results: Levels of sRAGE and esRAGE correlated strongly both at baseline and at follow ‑ up in both diabetes patients and controls. With increasing age, mean values of both variants declined, independent of gender, diabetes or pubertal stage. In the diabetes group, multiple regression analysis showed a positive association between both variants of solu ‑ ble RAGE and cIMT. There was no significant relationship with Young’s modulus, but a negative association between sRAGE at baseline and CRP at follow ‑ up. The ratios between the AGEs and the variants of soluble RAGE were increased in diabetes patients compared to controls. Conclusions: The results show a possible protective effect of high levels of sRAGE at baseline against inflammation 5 years later, but not on arterial stiffness or wall thickness, in this cohort of adolescents and young adults with T1D. Keywords: Advanced glycation end products, Receptor for advanced glycation end products, sRAGE, esRAGE, Atherosclerosis, Type 1 diabetes, CRP.

• Krogvold, Lars; Edwin, Bjørn; Buanes, Trond; Frisk, Gun; Skog, Oskar & Anagandula, Mahesh [Show all 19 contributors for this article] (2015). Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes. ISSN 0012-1797. 64(5), p. 1682–1687. doi: 10.2337/db14-1370. Show summary

  The Diabetes Virus Detection study (DiViD) is the first to examine fresh pancreatic tissue at the diagnosis of type 1 diabetes for the presence of viruses. Minimal pancreatic tail resection was performed 3-9 weeks after onset of type 1 diabetes in six adult patients (age 24-35 years). The presence of enteroviral capsid protein 1 (VP1) and the expression of class I HLA were investigated by immunohistochemistry. Enterovirus RNA was analyzed from isolated pancreatic islets and from fresh-frozen whole pancreatic tissue using PCR and sequencing. Nondiabetic organ donors served as controls. VP1 was detected in the islets of all type 1 diabetic patients (two of nine controls). Hyperexpression of class I HLA molecules was found in the islets of all patients (one of nine controls). Enterovirus-specific RNA sequences were detected in four of six patients (zero of six controls). The results were confirmed in various laboratories. Only 1.7% of the islets contained VP1(+) cells, and the amount of enterovirus RNA was low. The results provide evidence for the presence of enterovirus in pancreatic islets of type 1 diabetic patients, which is consistent with the possibility that a low-grade enteroviral infection in the pancreatic islets contributes to disease progression in humans.

• Basu, Arpita; Yu, Jeremy Y.; Jenkins, Alica J.; Nankervis, Alison J.; Hanssen, Kristian Folkvord & Henriksen, Tore [Show all 13 contributors for this article] (2015). Trace elements as predictors of preeclampsia in type 1 diabetic pregnancy. Nutrition Research. ISSN 0271-5317. 35(5), p. 421–430. doi: 10.1016/j.nutres.2015.04.004.
• Heier, Martin; MARGEIRSDOTTIR, HANNA DIS; Torjesen, Peter A; Seljeflot, Ingebjørg; STENSÆTH, KNUT-HAAKON & Gaarder, Mario [Show all 9 contributors for this article] (2015). The advanced glycation end product methylglyoxal-derived hydroimidazolone-1 and early signs of atherosclerosis in childhood diabetes. Diabetes & vascular disease research. ISSN 1479-1641. 12(2), p. 139–145. doi: 10.1177/1479164114560910.
• Sveen, Kari Anne; Dahl-Jørgensen, Knut; STENSÆTH, KNUT-HAAKON; Angel, Kristin; Seljeflot, Ingebjørg & Sell, David R [Show all 8 contributors for this article] (2015). Glucosepane and oxidative markers in skin collagen correlate with intima media thickness and arterial stiffness in long-term type 1 diabetes. Journal of Diabetes and its Complications (JDC). ISSN 1056-8727. 29(3), p. 407–412. doi: 10.1016/j.jdiacomp.2014.12.011.
• Heier, Martin; MARGEIRSDOTTIR, HANNA DIS; Brunborg, Cathrine; Hanssen, Kristian Folkvord; Dahl-Jørgensen, Knut & Seljeflot, Ingebjørg (2015). Inflammation in childhood type-1 diabetes; influence of glycemic control. Atherosclerosis. ISSN 0021-9150. 238, p. 33–37. doi: 10.1016/j.atherosclerosis.2014.11.018.
• Krogvold, Lars; Edwin, Bjørn; Buanes, Trond; Ludvigsson, Johnny; Korsgren, Olle & Hyöty, Heikki [Show all 9 contributors for this article] (2014). Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study. Diabetologia. ISSN 0012-186X. 57(4), p. 841–843. doi: 10.1007/s00125-013-3155-y.
• Sveen, Kari Anne; Nerdrum, Tone; Hanssen, Kristian Folkvord; Brekke, Magne; Torjesen, Peter A & Strauch, Christopher M [Show all 10 contributors for this article] (2014). Impaired left ventricular function and myocardial blood flow reserve in patients with long-term type 1 diabetes and no significant coronary artery disease: Associations with protein glycation. Diabetes & vascular disease research. ISSN 1479-1641. 11(2), p. 84–91. doi: 10.1177/1479164113518805.
• Eidem, Ingvild; Vangen, Siri; Henriksen, Tore; Vollset, Stein Emil; Hanssen, Kristian Folkvord & Joner, Geir [Show all 7 contributors for this article] (2014). Discrepancy in term calculation from second trimester ultrasound scan versus last menstrual period in women with type 1 diabetes. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 93(8), p. 809–816. doi: 10.1111/aogs.12422.
• Du, Mei; Basu, Arpita; Fu, Dongxu; Wu, Mingyuan; Centola, Michael & Jenkins, Alica J. [Show all 12 contributors for this article] (2013). Serum Inflammatory Markers and Preeclampsia in Type 1 Diabetes A prospective study. Diabetes Care. ISSN 0149-5992. 36(7), p. 2054–2061. doi: 10.2337/dc12-1934.
• Sveen, Kari Anne; Karimé, Bassam; Jørum, Ellen; Mellgren, Svein Ivar; Fagerland, Morten & Monnier, Vincent [Show all 8 contributors for this article] (2013). Small- and large-fiber neuropathy after 40 years of type 1 diabetes associations with glycemic control and advanced protein glycation: the Oslo Study. Diabetes Care. ISSN 0149-5992. 36(11), p. 3712–3717. doi: 10.2337/dc13-0788. Full text in Research Archive
• Yu, Y; Hanssen, Kristian Folkvord; Kalyanaraman, V; Chirindel, A; Jenkins, AJ & Nankervis, AJ [Show all 19 contributors for this article] (2012). Reduced soluble receptor for advanced glycation end-products (sRAGE) scavenger capacity precedes pre-eclampsia in Type 1 diabetes. BJOG: An International Journal of Obstetrics and Gynaecology. ISSN 1470-0328. 119(12), p. 1512–1520. doi: 10.1111/j.1471-0528.2012.03463.x.
• Basu, Arpita; Alaupovic, Petar; Wu, Mingyuan; Jenkins, Alica J.; Yu, Yongxin & Nankervis, Alison J. [Show all 19 contributors for this article] (2012). Plasma Lipoproteins and Preeclampsia in Women with Type 1 Diabetes: A Prospective Study. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 97(5), p. 1752–1762. doi: 10.1210/jc.2011-3255.
• Fraser, David; Diep, Lien My; Hynås, Inger Anette; Nilsen, Kristian Bernhard; Sveen, Kari Anne & Seljeflot, Ingebjørg [Show all 7 contributors for this article] (2012). The Effects of Long-Term Oral Benfotiamine Supplementation on Peripheral Nerve Function and Inflammatory Markers in Patients With Type 1 Diabetes A 24-month, double-blind, randomized, placebo-controlled trial. Diabetes Care. ISSN 0149-5992. 35(5), p. 1095–1097. doi: 10.2337/dc11-1895.
• Fraser, David; Hessvik, Nina Pettersen; Nikolic, Natasa; Aas, Vigdis; Hanssen, Kristian Folkvord & Bøhn, Siv Kjølsrud [Show all 8 contributors for this article] (2012). Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations. Genes & Nutrition. ISSN 1555-8932. doi: 10.1007/s12263-011-0252-8. Full text in Research Archive
• Berg, Jens Petter; Hanssen, Kristian Folkvord; Bjerve, Kristian S; Claudi, Tor; Dahl-Jørgensen, Knut & Rustad, Pål [Show all 8 contributors for this article] (2011). Standardisert hemoglobin A1C til diagnostisk bruk? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 131(6), p. 565–6. doi: 10.4045/tidsskr.10.1160.
• Eidem, Ingvild; Vangen, Siri; Hanssen, Kristian Folkvord; Vollset, Stein Emil; Henriksen, Tore & Joner, Geir [Show all 7 contributors for this article] (2011). Perinatal and infant mortality in term and preterm births among women with type 1 diabetes. Diabetologia. ISSN 0012-186X. 54(11), p. 2771–2778. doi: 10.1007/s00125-011-2281-7.
• Hanssen, Kristian Folkvord (2011). standardisert HbA1c. Tidsskrift for Den norske legeforening. ISSN 0029-2001. doi: 10.4045/tidsskr.10.1160.
• Lund, Terje; Svindland, Aud; Pepaj, Milaim; Jensen, Aase-Brith Ellefsen; Berg, Jens Petter & Kilhovd, Bente [Show all 7 contributors for this article] (2011). Fibrin(ogen) may be an important target for methylglyoxal-derived AGE modification in elastic arteries of humans. Diabetes & vascular disease research. ISSN 1479-1641. 8(4), p. 284–294. doi: 10.1177/1479164111416831.
• Azar, Madona; Basu, Arpita; Jenkins, Alica J.; Nankervis, Alison J.; Hanssen, Kristian Folkvord & Scholz, Hanne Bjørnson [Show all 12 contributors for this article] (2011). Serum Carotenoids and Fat-Soluble Vitamins in Women With Type 1 Diabetes and Preeclampsia A longitudinal study. Diabetes Care. ISSN 0149-5992. 34(6), p. 1258–1264. doi: 10.2337/dc10-2145.
• Eidem, Ingvild; Stene, Lars Christian; Henriksen, Tore; Hanssen, Kristian Folkvord; Vangen, Siri & Vollset, Stein Emil [Show all 7 contributors for this article] (2010). Congenital anomalies in newborns of women with type 1 diabetes: nationwide population-based study in Norway, 1999-2004. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 89(11), p. 1403–1411. doi: 10.3109/00016349.2010.518594.
• Yu, Y; Jenkins, AJ; Nankervis, AJ; Hanssen, Kristian Folkvord; Scholz, Hanne Bjørnson & Henriksen, Tore [Show all 21 contributors for this article] (2009). Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women. Diabetologia. ISSN 0012-186X. 52(1), p. 160–168. doi: 10.1007/s00125-008-1182-x.
• Bangstad, Hans J; Seljeflot, Ingebjørg; Berg, Tore Julsrud & Hanssen, Kristian Folkvord (2009). Renal tubulointerstitial expansion is associated with endothelial dysfunction and inflammation in type-1 diabetes. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 69(1), p. 138–144. doi: 10.1080/00365510802444080.
• Thorsby, Per Medbøe; Midthjell, Kristian; Gjerlaugsen, Nina; Holmen, Jostein; Hanssen, Kristian F & Birkeland, Kåre I [Show all 7 contributors for this article] (2009). Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study - the HUNT study. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 69(2), p. 282–287. doi: 10.1080/00365510802538188.
• Kilhovd, BK; Juutilainen, A; Lehto, S; Ronnemaa, T; Torjesen, PA & Hanssen, Kristian Folkvord [Show all 7 contributors for this article] (2009). Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women. Atherosclerosis. ISSN 0021-9150. 205(2), p. 590–594. doi: 10.1016/j.atherosclerosis.2008.12.041.
• Aas, Anne-Marie; Hanssen, Kristian Folkvord; Berg, Jens Petter; Thorsby, Per Medbøe & Birkeland, Kåre I. (2009). Insulin-Stimulated Increase in Serum Leptin Levels Precedes and Correlates with Weight Gain during Insulin Therapy in Type 2 Diabetes. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 94(8), p. 2900–2906. doi: 10.1210/jc.2008-1005.
• Fosmark, Dag Sigurd; Berg, Jens Petter; Jensen, Aase-Brith Ellefsen; Sandvik, Leiv; Agardh, Elisabet & Agardh, Carl-David [Show all 7 contributors for this article] (2009). Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone. Acta Ophthalmologica. ISSN 1755-375X. 87(5), p. 498–500. doi: 10.1111/j.1755-3768.2008.01300.x.
• Holan, Synne; Vangen, Siri; Hanssen, Kristian & Stray-Pedersen, Babill (2008). Diabetes hos gravide født i Asia, Afrika og Norge. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 128(11), p. 1289–1292.
• Hanssen, Kristian Folkvord (2008). increased retinopathy occurence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone. Acta Ophthalmologica. ISSN 1755-375X.
• Hanssen, Kristian Folkvord (2008). Advanced glycation end products in pregnancies. Hypertension in Pregnancy. ISSN 1064-1955. 27(4), p. 374–386.
• Hanssen, Kristian Folkvord (2008). Pregnancy in diabetes among Asian, African and norwegian women. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 128, p. 1289–1292.
• Harsem, Nina Kittelsen; Brække, Kristin; Torjussen, Tale Mæhre; Hanssen, Kristian Folkvord & Staff, Anne Cathrine (2008). Advanced Glycation End Products in Pregnancies Complicated with Diabetes Mellitus or Preeclampsia. Hypertension in Pregnancy. ISSN 1064-1955. 27(4), p. 374–386. doi: 10.1080/10641950802000968.
• Bangstad, Hans J; Seljeflot, Ingebjørg; Berg, Tore Julsrud & Hanssen, Kristian Folkvord (2008). Renal tubulointerstitial expansion is associated with endothelial dysfunction and inflammation in type 1 diabetes. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN 0036-5513. 10, p. 1–7. doi: 10.1080/00365510802444080.
• Fosmark, Dag Sigurd; Bragadottir, Ragnheidur; Stene-Johansen, Ingar; Berg, Jens Petter; Lund, Terje & Sandvik, Leiv [Show all 7 contributors for this article] (2007). Increased vitreous levels of hydroimidazolone in type 2 diabetes patients are associated with retinopathy: a case-control study. Acta Ophthalmologica Scandinavica. ISSN 1395-3907. 85, p. 618–622.
• Kilhovd, Bente; Juutilainen, A; Lehto, S; Ronnemaa, T; Torjesen, Peter A & Hanssen, Kristian Folkvord [Show all 7 contributors for this article] (2007). Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study. Diabetologia. ISSN 0012-186X. 50, p. 1409–1417. doi: 10.1007/s00125-007-0687-z.
• Birkeland, Kåre I.; Skeie, Svein & Hanssen, Kristian Folkvord (2006). Biomarkører ved diabetes. Norsk Epidemiologi. ISSN 0803-2491. 16(1), p. 15–21.
• Chawla, Jeevan Shikha; Amundsen, Ågot Lia; Hanssen, Kristian F. & Iversen, Per Ole (2006). Svangerskapsdiabetes hos kvinner fra Sør-Asia. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 126(8), p. 1041–1043.
• Skrivarhaug, T; Bangstad, HJ; Stene, Lars Christian; Sandvik, L; Hanssen, KF & Joner, G (2006). Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway. Diabetologia. ISSN 0012-186X. 49(2), p. 298–305. doi: 10.1007/s00125-005-0082-6.
• Skrivarhaug, T.; Fosmark, D.S.; Stene, Lars Christian; Bangstad, H.-J.; Sandvik, L. & Hanssen, K.F. [Show all 7 contributors for this article] (2006). Low cumulative incidence of proliferative retinopathy in childhood-onset type 1 diabetes: a 24-year follow-up study. Diabetologia. ISSN 0012-186X. 49(10), p. 2281–2290. doi: 10.1007/s00125-006-0364-7. Show summary

  AIMS/HYPOTHESIS: We estimated cumulative incidence of proliferative diabetic retinopathy (PDR) and risk factors for developing diabetic retinopathy (DR) in childhood-onset type 1 diabetes. MATERIALS AND METHODS: A sample of 294 patients with childhood-onset type 1 diabetes (<15 years) diagnosed in Norway between 1973 and 1982 was examined for retinopathy at baseline between 1989 and 1990 and at follow-up from 2002 to 2003. At follow-up, mean age was 33 years (range: 21-44), mean diabetes duration 24 years (19-30) and total person-time contributed 7,152 person-years. Retinal photographs were taken at baseline and follow-up. Associations between baseline factors and PDR were estimated using Cox regression models. RESULTS: Overall, 262 of 294 (89.1%) developed DR from diabetes onset, of whom 31 developed PDR. The 25-year cumulative incidence of PDR was 10.9% (95% CI 7.3-14.5). Among 194 without retinopathy at baseline, 163 (84%) developed DR and nine (5%) progressed to PDR. Among 97 patients with non-proliferative DR at baseline, 19 (20%) progressed to PDR. Significant predictors for developing PDR were retinopathy at baseline (relative risk [RR]=3.71, 95% CI 1.59-8.68), HbA(1c) (RR=2.05, 1.44-2.93), and triglycerides (RR=1.55, 1.06-1.95). CONCLUSIONS/INTERPRETATION: Nine out of every ten patients diagnosed with type 1 diabetes developed DR, but only one out of ten developed PDR within their first 25 years of diabetes duration. The cumulative incidence of PDR is lower than previously reported from other countries. Potentially modifiable risk factors predict the development of DR and PDR.

• Skrivarhaug, Torild; Bangstad, Hans-Jacob; Stene, Lars Christian; Sandvik, Leiv; Hanssen, Kristian F. & Joner, Geir (2006). Low risk of overt nephropathy after 24 yr of childhood-onset type 1 diabetes mellitus (T1DM) in Norway. Pediatric Diabetes. ISSN 1399-543X. 7(5), p. 239–246. doi: 10.1111/j.1399-5448.2006.00204.x. Show summary

  AIM: To estimate the risk of diabetic nephropathy and associated risk factors in a nationwide cohort of childhood-onset type 1 diabetes mellitus (T1DM) and 19-30 yr of diabetes duration. METHODS: Patients diagnosed with childhood-onset T1DM (<15 yr) from 1973 through 1982, who previously (1989-1990) participated in a clinical examination to assess diabetic complications, were invited for a new examination in 2002-2003. Of 355 eligible patients, 299 participated (84.2%), and complete urine samples for evaluation of albuminuria were obtained from 295 patients, with a mean age of 33 yr (range 20.9-44.0) and mean diabetes duration of 24 yr (range 19.3-29.9). Persistent microalbuminuria and overt nephropathy [albumin excretion rate (AER) 15-200 microg/min and AER > 200 microg/min, respectively] in at least two out of three consecutive overnight urine samples were defined as diabetic nephropathy. RESULTS: Overt nephropathy was found in 7.8% [95% confidence interval (CI) 4.7-10.9] and persistent microalbuminuria in 14.9% (95% CI 10.8-19.0) of the subjects. Hemoglobin A1c (HbA1c) (p = 0.001), systolic blood pressure (BP) (p = 0.002), total cholesterol (p = 0.019), and C-reactive protein (CRP) (p = 0.019) were associated with diabetic nephropathy. Significant predictors in 1989-1990 for the development of diabetic nephropathy in 2002-2003 were HbA1c (p < 0.001), AER (p = 0.007), and cholesterol (p = 0.022). CONCLUSIONS: In a subgroup of patients diagnosed with childhood-onset T1DM in 1973-1982, 7.8% had overt nephropathy after 19-30 yr of diabetes duration, which is low compared with studies from other countries. HbA1c, systolic BP, total cholesterol, and CRP were each independently associated with diabetic nephropathy.

• Dahl-Jørgensen, Knut; Larsen, Jakob & Hanssen, Kristian Folkvord (2005). Atherosclerosis in childhood and adolescent type 1 diabetes: early disease, early treatment? Diabetologia. ISSN 0012-186X. 48.
• Kilhovd, Bente K.; Juutilainen, A.; Lehto, S.; Rönnemaa, T.; Torjesen, Peter A. & Birkeland, Kåre I. [Show all 9 contributors for this article] (2005). High Serum Levels of Advanced Glycation End Products Predict Increased Coronary Heart Disease Mortality in Nondiabetic Women but not in Nondiabetic Men. A population-Based 18- Year Follow-Up Study. Arteriosclerosis, Thrombosis and Vascular Biology. ISSN 1079-5642. 25(4), p. 815–20.
• Skrivarhaug, T; Bangstad, Hans J; Stene, LC; Sandvik, L.; Hanssen, Kristian Folkvord & Joner, G (2005). Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway. Diabetologia. ISSN 0012-186X. 20, p. 1–8.
• Larsen, Jakob; Brekke, M; Bergengen, L; Sandvik, L; Arnesen, Harald & Hanssen, Kristian Folkvord [Show all 7 contributors for this article] (2005). Mean HbA1c over 18 years predicts carotid intima media thickness in women with type 1 diabetes. Diabetologia. ISSN 0012-186X. 48(4), p. 776–779.
• Hanssen, Kristian Folkvord (2004). Type 2 Diabetes er flere sykdommer. In Vaaler, Stein (Eds.), Diabeteshåndboken. Gyldendal Akademisk. p. 36–41.
• Hanssen, Kristian Folkvord (2004). Diabetisk ketoacidose og non-ketotisk ukontrollert diabetes. In Vaaler, Stein (Eds.), Diabeteshåndboken. Gyldendal Akademisk. p. 182–185.
• Hanssen, Kristian Folkvord (2004). Graviditet og diabetes - en viktig terapeutisk utfordring. In Vaaler, Stein (Eds.), Diabeteshåndboken. Gyldendal Akademisk. p. 284–288.
• Larsen, Jakob; Sjøholm, Hans; Berg, Tore Julsrud; Sandvik, Leiv; Brekke, Magne & Hanssen, Kristian Folkvord [Show all 7 contributors for this article] (2004). Eighteen Years of Fair Glycemic Control Preserves Cardiac Autonomic Function in Type 1 Diabetes. Diabetes Care. ISSN 0149-5992. 27(4), p. 963–6.
• Hanssen, Kristian Folkvord (2004). Offloading in patients with diabetic foot ulceration. International Diabetes Monitor. ISSN 0924-3623. 16, p. 237–239.
• Larsen, Jakob R.; Sjøholm, H.; Hanssen, Kristian Folkvord; Sandvik, Leiv; Berg, T Julsrud & Dahl-Jørgensen, Knut (2003). Optimal blood glucose control during 18 years preserves peripheral nerve function in patients with 30 years' duration of type 1 diabetes. Diabetes Care. ISSN 0149-5992. 26(8), p. 2400–4.
• Hanssen, Kristian Folkvord (2003). Melkesyreacidose som bivirkning av metformin. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 123(18), p. 2583–84.
• Kilhovd, Bente K.; Giardino, I.; Torjesen, Peter A.; Birkeland, Kåre I.; Berg, Tore Julsrud & Thornalley, P.J. [Show all 8 contributors for this article] (2003). Increased serum levels of the specific AGE-compound methylglyoxal derived hydroimidazolone in patients with type 2 diabetes. Metabolism: Clinical and Experimental. ISSN 0026-0495. 52(2), p. 163–7.
• Birkeland, Kåre I.; Kilhovd, Bente K.; Thorsby, Per; Torjesen, Peter A.; Ganss, R. & Vaaler, Stein [Show all 7 contributors for this article] (2003). Heterogeneity of non-insulin dependent diabetes expressed as variability in insulin sensivity, beta cell function and cardiovascular risk profile. Diabetic Medicine. ISSN 0742-3071. 20(1), p. 37–45.

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• Christophersen, Y. & Hanssen, Kristian Folkvord (2004). Diabetes for livet: aldri fred å få? Eget forlag. ISBN 82-996870-0-4. 224 p.

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• Henriksen, Tore; Jenum, Anne Karen; Thordarson, Hrafnkell B; Holm, Helene Oeding; Gudim, Hilde Beate & Hanssen, Kristian Folkvord (2018). Backes sammensurium av retningslinjer. Tidsskrift for Den norske legeforening. ISSN 0029-2001.
• Henriksen, Tore; Jenum, Anne Karen; Thordarson, Hrafnkell B; Holm, Helene Oeding; Gudim, Hilde Beate & Hanssen, Kristian Folkvord (2018). Backe's budskap til norske kolleger: Glem svangerskapsdiabetes. Tidsskrift for Den norske legeforening. ISSN 0029-2001.
• Henriksen, Tore; Jenum, Anne Karen; Thordarson, Hrafnkell B; Holm, Helene Oeding; Gudim, Hilde Beate & Hanssen, Kristian Folkvord (2018). Lite nytt i kritikk av retningslinjene for svangerskapsdiabetes. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 138(10), p. 894–894. doi: 10.4045/tidsskr.18.0430.
• Hanssen, Kristian Folkvord; Jenum, Anne Karen; Henriksen, Tore; Bjerkan, Kirsti; Gudim, Hilde Beate & Holm, Helene Oeding [Show all 7 contributors for this article] (2017). Svangerskapsomsorg på rett vei. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116.
• Sveen, Kari Anne; Ørstavik, Kristin; Fosmark, Dag Sigurd; Dahl-Jørgensen, Knut & Hanssen, Kristian Folkvord (2013). Retinal nerve fibre layer thickness is associated with measures of small fibre neuropathy in long-term type 1 diabetes. Diabetologia. ISSN 0012-186X. 56, p. S499–S500.
• Fraser, David; Diep, Lien My; Hynås, Inger Anette; Nilsen, Kristian Bernhard; Sveen, Kari Anne & Seljeflot, Ingebjørg [Show all 7 contributors for this article] (2012). The effects of oral benfotiamine on peripheral nerve function and inflammatory markers in type-1 diabetes: a 24-month, double-blind, randomised, placebo-controlled trial. European Journal of Neurology. ISSN 1351-5101. 19, p. 416–416.
• Hanssen, Kristian Folkvord (2012). Legene og legemiddelindustrien. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 132, p. 386–387.
• Eidem, Ingvild; Vangen, Siri; Hanssen, Kristian Folkvord; Vollset, Stein Emil; Henriksen, Tore & Joner, Geir [Show all 7 contributors for this article] (2012). Perinatal and Infant Mortality in Term and Preterm Births Among Women With Type 1 Diabetes EDITORIAL COMMENT. Obstetrical and Gynecological Survey. ISSN 0029-7828. 67(3), p. 139–141. doi: 10.1097/OGX.0b013e31824b6f5f.
• Fraser, David; Diep, Lien My; Hynås, Inger Anette; Nilsen, Kristian Bernhard; Sveen, Kari Anne & Seljeflot, Ingebjørg [Show all 7 contributors for this article] (2012). Response to Comment on: Fraser et al. The Effects of Long-Term Oral Benfotiamine Supplementation on Peripheral Nerve Function and Inflammatory Markers in Patients With Type 1 Diabetes: A 24-Month, Double-Blind, Randomized, Placebo-Controlled Trial. Diabetes Care 2012;35:1095-1097. Diabetes Care. ISSN 0149-5992. 35(11), p. E80–E80. doi: 10.2337/dc12-1124.
• Wu, M.; Du, M; Jenkins, A.; Nankervis, AJ; Hanssen, Kristian Folkvord & Scholz, Hanne Bjørnson [Show all 18 contributors for this article] (2010). CIRCULATING CYTOKINES PREDICT PRE-ECLAMPSIA IN TYPE 1 DIABETES MELLITUS. Journal of Investigative Medicine. ISSN 1081-5589. 58(2), p. 392–392.
• Skrivarhaug, T; Fosmark, D; Bangstad, HJ; Stene, Lars Christian; Sandvik, L & Hanssen, KF [Show all 7 contributors for this article] (2008). Appearance of retinopathy and progression to proliferative retinopathy in childhood-onset type 1 diabetes: a long-term follow-up study. Acta Ophthalmologica. ISSN 1755-375X. 86.
• Thorsby, Per M; Midthjell, Kristian; Gjerlaugsen, N; Krüger, Øystein; Holmen, Jostein & Hanssen, Kristian [Show all 8 contributors for this article] (2006). Analyses of two major candidate genes for type 2 diabetes - does it provide additional information to traditional risk factors in prediction of diabetes: the HUNT study? Diabetic Medicine. ISSN 0742-3071. 23.
• Skrivarhaug, Torild; Bangstad, Hans J; Sandvik, Leiv; Hanssen, Kristian Folkvord & Joner, Geir (2004). Predictors of microalbuminuria and overt nephropathy in patients with type 1 diabetes: a population-based, longitudinal survey. Pediatric Diabetes. ISSN 1399-543X. 5.
• Skrivarhaug, Torild; Bangstad, Hans J; Sandvik, Leiv; Hanssen, Kristian Folkvord & Joner, Geir (2004). Low prevalence of clinical nephropathy after 24 years of Type 1 diabetes; a Norwegian population based cohort study.
• Skrivarhaug, Torild; Bangstad, Hans J; Sandvik, L; Hanssen, Kristian Folkvord & Joner, Geir (2004). Cholesterol, HbA1c and AER are predictors of diabetic kidney disease in type 1 diabetes.
• Hanssen, Kristian Folkvord (2003). Behandling med kombinasjon av insulin og perorale antidiabetika med type 2 Diabetes. Diabetes avisen. ISSN 0803-8260. p. 8–9.
• Hanssen, Kristian Folkvord (2003). Type 1 Diabetes gjennom 80 år. Diabetes (Oslo). ISSN 1502-1424.
• Hanssen, Kristian Folkvord (2003). Kombinasjonsbehandling ved type 2 Diabetes. Diabetes (Oslo). ISSN 1502-1424.
• Hanssen, Kristian Folkvord (2003). Betacellen kan vekkes? Diabetes (Oslo). ISSN 1502-1424.
• Hanssen, Kristian Folkvord (2003). Over 30 % risiko for å få diabetes i USA! Diabetes (Oslo). ISSN 1502-1424.
• Hanssen, Kristian Folkvord (2003). Vitaminer mot senkomplikasjoner? Diabetes (Oslo). ISSN 1502-1424.
• Hanssen, Kristian Folkvord (2003). GLP-1 - den nye vidundermedisinen? Diabetes (Oslo). ISSN 1502-1424.
• Larsen, J; Bergengen, L.; Sandvik, Leiv; Arnesen, Harald; Hanssen, Kristian Folkvord & Dahl-Jørgensen, Knut (2003). Mean HbA1c during 18 years predicts common carotide artery intima-media thickness in women with type-1 diabetes.
• Hanssen, Kristian Folkvord (2002). Totalkolesterol/HDL kolesterol som risikofaktor for hjerte-karsykdom ved diabetes. Diabetes for helsepersonell. ISSN 0809-3016. 1, p. 14–15.
• Hanssen, Kristian Folkvord (2002). Behandling med kombinasjon av insulin og perorale antidiabetika ved type 2. Diabetes for helsepersonell. ISSN 0809-3016. 3, p. 20–21.
• Hanssen, Kristian Folkvord (2002). Diabetisk nyresykdom kan forsinkes. Diabetes. ISSN 0012-1797. 1.
• Hanssen, Kristian Folkvord (2002). HbA1c på kjøleskapet? Diabetes. ISSN 0012-1797. 2.

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