Kyrre Eeg Emblem

• Luque Fernandez, Lidia; Skogen, Karoline; MacIntosh, Bradley; Emblem, Kyrre E; Larsson, Christopher & Bouget, David Nicolas Jean-Marie [Show all 14 contributors for this article] (2024). Standardized evaluation of the extent of resection in glioblastoma with automated early post-operative segmentation. Frontiers in Radiology. ISSN 2673-8740. 4. doi: 10.3389/fradi.2024.1357341.
• Blakstad, Hanne Kristin; Mireles, Eduardo Erasmo Mendoza; Kierulf-Vieira, Kirsten Strømme; Singireddy, Divija; Mdala, Ibrahimu & Heggebø, Liv Cathrine [Show all 16 contributors for this article] (2024). The impact of cancer patient pathway on timing of radiotherapy and survival: a cohort study in glioblastoma patients. Journal of Neuro-Oncology. ISSN 0167-594X. doi: 10.1007/s11060-024-04709-z.
• Kim, Albert E.; Lou, Kevin W.; Giobbie-Hurder, Anita; Chang, Ken; Gidwani, Mishka & Hoebel, Katharina [Show all 43 contributors for this article] (2024). Abnormal vascular structure and function within brain metastases is linked to pembrolizumab resistance. Neuro-Oncology. ISSN 1522-8517. 26(5), p. 965–974. doi: 10.1093/neuonc/noad236.
• Blakstad, Hanne Kristin; Mireles, Eduardo Erasmo Mendoza; Heggebø, Liv Cathrine; Magelssen, Henriette; Sprauten, Mette & Johannesen, Tom Børge [Show all 13 contributors for this article] (2023). Incidence and outcome of pseudoprogression after radiation therapy in glioblastoma patients: A cohort study. Neuro-Oncology Practice. ISSN 2054-2577. 11(1), p. 36–45. doi: 10.1093/nop/npad063.
• Osadebey, Michael; Liu, Qinghui; Fuster-Garcia, Elies & Emblem, Kyrre E (2023). Interpreting deep learning models for glioma survival classification using visualization and textual explanations. BMC Medical Informatics and Decision Making. ISSN 1472-6947. 23(1). doi: 10.1186/s12911-023-02320-2.
• Lysvik, Elisabeth Kirkeby; Mikalsen, Lars Tore Gyland; Rootwelt-Revheim, Mona Elisabeth; Emblem, Kyrre Eeg & Hjørnevik, Trine (2023). Optimization of Q.Clear reconstruction for dynamic 18F PET imaging. EJNMMI Physics. ISSN 2197-7364. 10(1), p. 1–13. doi: 10.1186/s40658-023-00584-1. Full text in Research Archive Show summary

  Background: Q.Clear, a Bayesian penalized likelihood reconstruction algorithm, has shown high potential in improving quantitation accuracy in PET systems. The Q.Clear algorithm controls noise during the iterative reconstruction through a β penalization factor. This study aimed to determine the optimal β-factor for accurate quantitation of dynamic PET scans. Methods: A Flangeless Esser PET Phantom with eight hollow spheres (4-25 mm) was scanned on a GE Discovery MI PET/CT system. Data were reconstructed into five sets of variable acquisition times using Q.Clear with 18 different β-factors ranging from 100 to 3500. The recovery coefficient (RC), coefficient of variation (CVRC) and root-mean-square error (RMSERC) were evaluated for the phantom data. Two male patients with recurrent glioblastoma were scanned on the same scanner using 18F-PSMA-1007. Using an irreversible two-tissue compartment model, the area under curve (AUC) and the net influx rate Ki were calculated to assess the impact of different β-factors on the pharmacokinetic analysis of clinical PET brain data. Results: In general, RC and CVRC decreased with increasing β-factor in the phantom data. For small spheres (

• MacIntosh, Bradley; Liu, Qinghui; SCHELLHORN, TILL; Beyer, Mona K.; Groote, Inge Rasmus & Morberg, Pål [Show all 20 contributors for this article] (2023). Radiological features of brain hemorrhage through automated segmentation from computed tomography in stroke and traumatic brain injury. Frontiers in Neurology. ISSN 1664-2295. 14. doi: 10.3389/fneur.2023.1244672. Full text in Research Archive
• Lauer, Arne; Speroni, Samantha L.; Choi, Myoung; Da, Xiao; Duncan, Christine & McCarthy, Siobhan [Show all 18 contributors for this article] (2023). Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy. Nature Communications. ISSN 2041-1723. 14. doi: 10.1038/s41467-023-37262-w.
• Hangel, Gilbert; Schmitz-Abecassis, Bárbara; Sollmann, Nico; Pinto, Joana; Arzanforoosh, Fatemehsadat & Barkhof, Frederik [Show all 41 contributors for this article] (2023). Advanced MR Techniques for Preoperative Glioma Characterization: Part 2. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. 57(6), p. 1676–1695. doi: 10.1002/jmri.28663. Full text in Research Archive
• Svensson, Siri Fløgstad; Halldórsso, Skarphéðinn; Latysheva, Anna; Fuster i Garcia, Elies; Hjornevik, Trine & Fraser-Green, Jorunn [Show all 12 contributors for this article] (2023). MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients. Neuro-Oncology Advances (NOA). 5(1). doi: 10.1093/noajnl/vdad021. Full text in Research Archive
• Hirschler, Lydiane; Sollmann, Nico; Schmitz-Abecassis, Bárbara; Pinto, Joana; Arzanforoosh, Fatemehsadat & Barkhof, Frederik [Show all 41 contributors for this article] (2023). Advanced MR Techniques for Preoperative Glioma Characterization: Part 1. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. 57(6), p. 1655–1675. doi: 10.1002/jmri.28662. Full text in Research Archive
• Ottesen, Jon André; Yi, Darvin; Tong, Elizabeth; Iv, Michael; Latysheva, Anna & Saxhaug, Cathrine [Show all 12 contributors for this article] (2023). 2.5D and 3D segmentation of brain metastases with deep learning on multinational MRI data. Frontiers in Neuroinformatics. ISSN 1662-5196. 16, p. 1–12. doi: 10.3389/fninf.2022.1056068. Full text in Research Archive Show summary

  Introduction: Management of patients with brain metastases is often based on manual lesion detection and segmentation by an expert reader. This is a time- and labor-intensive process, and to that end, this work proposes an end-to-end deep learning segmentation network for a varying number of available MRI available sequences. Methods: We adapt and evaluate a 2.5D and a 3D convolution neural network trained and tested on a retrospective multinational study from two independent centers, in addition, nnU-Net was adapted as a comparative benchmark. Segmentation and detection performance was evaluated by: (1) the dice similarity coefficient, (2) a per-metastases and the average detection sensitivity, and (3) the number of false positives. Results: The 2.5D and 3D models achieved similar results, albeit the 2.5D model had better detection rate, whereas the 3D model had fewer false positive predictions, and nnU-Net had fewest false positives, but with the lowest detection rate. On MRI data from center 1, the 2.5D, 3D, and nnU-Net detected 79%, 71%, and 65% of all metastases; had an average per patient sensitivity of 0.88, 0.84, and 0.76; and had on average 6.2, 3.2, and 1.7 false positive predictions per patient, respectively. For center 2, the 2.5D, 3D, and nnU-Net detected 88%, 86%, and 78% of all metastases; had an average per patient sensitivity of 0.92, 0.91, and 0.85; and had on average 1.0, 0.4, and 0.1 false positive predictions per patient, respectively. Discussion/Conclusion: Our results show that deep learning can yield highly accurate segmentations of brain metastases with few false positives in multinational data, but the accuracy degrades for metastases with an area smaller than 0.4 cm2.

• Datta, Meenal; Chatterjee, Sampurna; Perez, Elizabeth M.; Gritsch, Simon; Roberge, Sylvie & Duquette, Mark [Show all 27 contributors for this article] (2023). Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 120:e2219199120(6), p. 1–11. doi: 10.1073/pnas.2219199120.
• Bouget, David Nicolas Jean-Mar; Pedersen, André; Jakola, Asgeir S.; Kavouridis, Vasileios; Emblem, Kyrre Eeg & Eijgelaar, Roelant S [Show all 30 contributors for this article] (2022). Preoperative Brain Tumor Imaging: Models and Software for Segmentation and Standardized Reporting. Frontiers in Neurology. ISSN 1664-2295. 13, p. 1–18. doi: 10.3389/fneur.2022.932219. Full text in Research Archive Show summary

  For patients suffering from brain tumor, prognosis estimation and treatment decisions are made by a multidisciplinary team based on a set of preoperative MR scans. Currently, the lack of standardized and automatic methods for tumor detection and generation of clinical reports, incorporating a wide range of tumor characteristics, represents a major hurdle. In this study, we investigate the most occurring brain tumor types: glioblastomas, lower grade gliomas, meningiomas, and metastases, through four cohorts of up to 4,000 patients. Tumor segmentation models were trained using the AGU-Net architecture with different preprocessing steps and protocols. Segmentation performances were assessed in-depth using a wide-range of voxel and patient-wise metrics covering volume, distance, and probabilistic aspects. Finally, two software solutions have been developed, enabling an easy use of the trained models and standardized generation of clinical reports: Raidionics and Raidionics-Slicer. Segmentation performances were quite homogeneous across the four different brain tumor types, with an average true positive Dice ranging between 80 and 90%, patient-wise recall between 88 and 98%, and patient-wise precision around 95%. In conjunction to Dice, the identified most relevant other metrics were the relative absolute volume difference, the variation of information, and the Hausdorff, Mahalanobis, and object average symmetric surface distances. With our Raidionics software, running on a desktop computer with CPU support, tumor segmentation can be performed in 16–54 s depending on the dimensions of the MRI volume. For the generation of a standardized clinical report, including the tumor segmentation and features computation, 5–15 min are necessary. All trained models have been made open-access together with the source code for both software solutions and validation metrics computation. In the future, a method to convert results from a set of metrics into a final single score would be highly desirable for easier ranking across trained models. In addition, an automatic classification of the brain tumor type would be necessary to replace manual user input. Finally, the inclusion of post-operative segmentation in both software solutions will be key for generating complete post-operative standardized clinical reports.

• Harkos, Constantinos; Svensson, Siri Fløgstad; Emblem, Kyrre E & Stylianopoulos, Triantafyllos (2022). Inducing Biomechanical Heterogeneity in Brain Tumor Modeling by MR Elastography: Effects on Tumor Growth, Vascular Density and Delivery of Therapeutics. Cancers. ISSN 2072-6694. 14(4), p. 1–19. doi: 10.3390/cancers14040884. Full text in Research Archive
• Fuster-Garcia, Elies; Hovden, Ivar Thokle; Svensson, Siri Fløgstad; Larsson, Christopher; Vardal, Jonas & Bjørnerud, Atle [Show all 7 contributors for this article] (2022). Quantification of Tissue Compression Identifies High-Grade Glioma Patients with Reduced Survival. Cancers. ISSN 2072-6694. 14(7). doi: 10.3390/cancers14071725.
• Petr, Jan; Hogeboom, Louise; Nikulin, Pavel; Wiegers, Evita; Schroyen, Gwen & Kallehauge, Jesper [Show all 20 contributors for this article] (2021). A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue. Magnetic Resonance Materials in Physics, Biology and Medicine. ISSN 0968-5243. 35, p. 163–186. doi: 10.1007/s10334-021-00985-2.
• Svensson, Siri Fløgstad; Fuster i Garcia, Elies; Latysheva, Anna; Fraser-Green, Jorunn; Nordhøy, Wibeke & Darwish, Omar Isam [Show all 11 contributors for this article] (2021). Decreased tissue stiffness in glioblastoma by MR elastography is associated with increased cerebral blood flow. European Journal of Radiology. ISSN 0720-048X. 147. doi: 10.1016/j.ejrad.2021.110136. Full text in Research Archive
• Yi, Darvin; Grøvik, Endre; Tong, Elizabeth; Iv, Michael; Emblem, Kyrre E & Nilsen, Line [Show all 12 contributors for this article] (2021). MRI pulse sequence integration for deep-learning-based brain metastases segmentation. Medical Physics (Lancaster). ISSN 0094-2405. 48(10), p. 6020–6035. doi: 10.1002/mp.15136.
• Álvarez-Torres, María Del Mar; Fuster i Garcia, Elies; Reynés, Gaspar; Juan-Albarracín, Javier; Chelebian, Eduard & Oleaga, Laura [Show all 13 contributors for this article] (2021). Differential effect of vascularity between long- and short-term survivors with IDH1/2 wild-type glioblastoma. NMR in Biomedicine. ISSN 0952-3480. 34(4). doi: 10.1002/nbm.4462.
• Grøvik, Endre; Yi, Darvin; Iv, Michael; Tong, Elizabeth; Nilsen, Line & Latysheva, Anna [Show all 12 contributors for this article] (2021). Handling missing MRI sequences in deep learning segmentation of brain metastases: a multicenter study. npj Digital Medicine. 4, p. 1–7. doi: 10.1038/s41746-021-00398-4. Show summary

  The purpose of this study was to assess the clinical value of a deep learning (DL) model for automatic detection and segmentation of brain metastases, in which a neural network is trained on four distinct MRI sequences using an input-level dropout layer, thus simulating the scenario of missing MRI sequences by training on the full set and all possible subsets of the input data. This retrospective, multicenter study, evaluated 165 patients with brain metastases. The proposed input-level dropout (ILD) model was trained on multisequence MRI from 100 patients and validated/tested on 10/55 patients, in which the test set was missing one of the four MRI sequences used for training. The segmentation results were compared with the performance of a state-of-the-art DeepLab V3 model. The MR sequences in the training set included pre-gadolinium and post-gadolinium (Gd) T1-weighted 3D fast spin echo, post-Gd T1-weighted inversion recovery (IR) prepped fast spoiled gradient echo, and 3D fluid attenuated inversion recovery (FLAIR), whereas the test set did not include the IR prepped image-series. The ground truth segmentations were established by experienced neuroradiologists. The results were evaluated using precision, recall, Intersection over union (IoU)-score and Dice score, and receiver operating characteristics (ROC) curve statistics, while the Wilcoxon rank sum test was used to compare the performance of the two neural networks. The area under the ROC curve (AUC), averaged across all test cases, was 0.989 ± 0.029 for the ILD-model and 0.989 ± 0.023 for the DeepLab V3 model (p = 0.62). The ILD-model showed a significantly higher Dice score (0.795 ± 0.104 vs. 0.774 ± 0.104, p = 0.017), and IoU-score (0.561 ± 0.225 vs. 0.492 ± 0.186, p < 0.001) compared to the DeepLab V3 model, and a significantly lower average false positive rate of 3.6/patient vs. 7.0/patient (p < 0.001) using a 10 mm3 lesion-size limit. The ILD-model, trained on all possible combinations of four MRI sequences, may facilitate accurate detection and segmentation of brain metastases on a multicenter basis, even when the test cohort is missing input MRI sequences.

• Kim, M.; Park, J.E.; Emblem, K.; Bjørnerud, Atle & Kim, H.S. (2021). Vessel type determined by vessel architectural imaging improves differentiation between early tumor progression and pseudoprogression in glioblastoma. American Journal of Neuroradiology. ISSN 0195-6108. 42(4), p. 663–670. doi: 10.3174/AJNR.A6984. Full text in Research Archive
• Svensson, Siri Fløgstad; De Arcos, José; Darwish, Omar Isam; Fraser-Green, Jorunn; Storås, Tryggve & Holm, Sverre [Show all 9 contributors for this article] (2021). Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. 53(5), p. 1510–1521. doi: 10.1002/jmri.27475. Full text in Research Archive
• Gerstner, Elizabeth R; Emblem, Kyrre E; Yen, Yi-Fen; Dietrich, Jorg; Jordan, Justin T & Catana, Ciprian [Show all 13 contributors for this article] (2020). Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients. Neuro-Oncology Advances (NOA). 2(1). doi: 10.1093/noajnl/vdaa157.
• Clement, Patricia; Booth, Thomas; Borovečki, Fran; Emblem, Kyrre Eeg; Figueiredo, Patrícia & Hirschler, Lydiane [Show all 15 contributors for this article] (2020). GliMR: Cross-Border Collaborations to Promote Advanced MRI Biomarkers for Glioma. Journal of Medical and Biological Engineering (JMBE). ISSN 1609-0985. p. 1–11. doi: 10.1007/s40846-020-00582-z.
• Leone, Jose Pablo; Emblem, Kyrre Eeg; Weitz, Michelle; Gelman, Rebekka S.; Schneider, Bryan P. & Freedman, Rachel A. [Show all 18 contributors for this article] (2020). Phase II trial of carboplatin and bevacizumab in patients with breast cancer brain metastases. Breast Cancer Research. ISSN 1465-5411. 22. doi: 10.1186/s13058-020-01372-w.
• Yogananda, Chandan Ganesh B.; Shah, Bhavya R.; Vejdani-Jahromi, Maryam; Nalawade, Sahil S.; Murugesan, Gowtham K. & Yu, Frank F. [Show all 13 contributors for this article] (2020). A Fully Automated Deep Learning Network for Brain Tumor Segmentation. Tomography. ISSN 2379-1381. 6(2), p. 186–193. doi: 10.18383/j.tom.2019.00026.
• Fuster i Garcia, Elies; Lorente Estellés, David; Álvarez-Torres, Maria del Mar; Juan-Albarracín, Javier; Chelebian, Eduard & Rovira, Alex [Show all 15 contributors for this article] (2020). MGMT methylation may benefit overall survival in patients with moderately vascularized glioblastomas. European Radiology. ISSN 0938-7994. doi: 10.1007/s00330-020-07297-4.
• van den Boomen, Maaike; Manhard, Mary Kate; Snel, Gert Jan H.; Han, SoHyun; Emblem, Kyrre E & Slart, Riemer H.J.A. [Show all 13 contributors for this article] (2020). Blood Oxygen Level–Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging. Radiology. ISSN 0033-8419. 294(2), p. 538–545. doi: 10.1148/radiol.2020191845.
• Digernes, Ingrid; Nilsen, Line; Grøvik, Endre; Bjørnerud, Atle; Løvland, Grethe & Vik-Mo, Einar O. [Show all 12 contributors for this article] (2020). Noise dependency in vascular parameters from combined gradient-echo and spin-echo DSC MRI. Physics in Medicine and Biology. ISSN 0031-9155. 65(22). doi: 10.1088/1361-6560/abb71a. Full text in Research Archive
• Nilsen, Line Brennhaug; Digernes, Ingrid; Grøvik, Endre; Saxhaug, Cathrine; Latysheva, Anna & Geier, Oliver [Show all 11 contributors for this article] (2020). Responses in the diffusivity and vascular function of the irradiated normal brain are seen up until 18 months following SRS of brain metastases. Neuro-Oncology Advances (NOA). 2(1). doi: 10.1093/noajnl/vdaa028. Full text in Research Archive
• Latysheva, Anna; Geier, Oliver; Hope, Tuva Roaldsdatter; Brunetti, Marta; Micci, Francesca & Vik-Mo, Einar O. [Show all 8 contributors for this article] (2020). Diagnostic utility of Restriction Spectrum Imaging in the characterization of the peritumoral brain zone in glioblastoma: Analysis of overall and progression-free survival. European Journal of Radiology. ISSN 0720-048X. 132:109289, p. 1–8. doi: 10.1016/j.ejrad.2020.109289. Full text in Research Archive
• Larsson, Christopher; Groote, Inge Rasmus; Vardal, Jonas; Kleppestø, Magne Mørk; Odland, Audun & Brandal, Petter [Show all 13 contributors for this article] (2020). Prediction of survival and progression in glioblastoma patients using temporal perfusion changes during radiochemotherapy. Magnetic Resonance Imaging. ISSN 0730-725X. 68, p. 106–112. doi: 10.1016/j.mri.2020.01.012. Full text in Research Archive
• Hovden, Ivar Thokle; Geier, Oliver; Digernes, Ingrid; Fuster i Garcia, Elies; Løvland, Grethe & Vik-Mo, Einar O. [Show all 8 contributors for this article] (2020). The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma. European Journal of Radiology. ISSN 0720-048X. doi: 10.1016/j.ejrad.2020.109278. Show summary

  Purpose Relative cerebral blood volume (rCBV) from dynamic susceptibility contrast (DSC)-MRI is a valuable biomarker in patients with glioblastoma for assessing treatment response and predicting overall survival. DSC-MRI based on echo planar images (EPI) may possess severe geometric distortions from magnetic field inhomogeneities up to the order of centimeters. The aim of this study is to assess how much two readily available EPI-based geometric distortion correction methods, FSL TOPUP and EPIC, affect rCBV values from DSC-MRI in patients with confirmed glioblastoma. Method We used a combined single-shot 2D gradient-echo (T2*), spin-echo (T2) EPI sequence to estimate both T2* and T2-weighted rCBV from the same contrast agent injection. Effects of distortion correction on the positive phase-encoded T2- and T2*-images were assessed in healthy anatomical brain regions in terms of Wilcoxon signed rank tests on median rCBV change and on Dice coefficients, as well as in tumor lesions in terms of Wilcoxon signed rank tests on median rCBV change. Results Our results show that following distortion correction, both gradient-echo and spin-echo rCBV increased in cortical areas of the frontal, temporal and occipital lobe, including the posterior orbital gyri in the frontal lobe and middle frontal gyri (p 

• Nilsen, Line; Grøvik, Endre; Digernes, Ingrid; Saxhaug, Cathrine; Latysheva, Anna & Geier, Oliver [Show all 12 contributors for this article] (2019). Vascular responses in normal brain tissue after combined immunotherapy and SRS to brain metastases. Radiotherapy and Oncology. ISSN 0167-8140. 133, p. 551–552. doi: 10.1016/S0167-8140(19)31420-3.
• Gerstner, Elizabeth R.; Emblem, Kyrre E; Chang, K; Vakulenko-Lagun, B; Yen, YF & Beers, AL [Show all 15 contributors for this article] (2019). Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma. Clinical Cancer Research. ISSN 1078-0432. 26(1), p. 206–212. doi: 10.1158/1078-0432.CCR-19-1739.
• Álvarez-Torres, Maria del Mar; Juan-Albarracín, Javier; Fuster i Garcia, Elies; Bellvís-Bataller, Fuensanta; Lorente, David & Reynés, Gaspar [Show all 29 contributors for this article] (2019). Robust association between vascular habitats and patient prognosis in glioblastoma: An international multicenter study. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. p. 1–9. doi: 10.1002/jmri.26958.
• Due-Tønnessen, Paulina; Pinho, Marco C.; Emblem, Kyrre E; Hald, John K; Kanoto, Masafumi & Abildgaard, Andreas [Show all 10 contributors for this article] (2019). The impact of MRI features and observer confidence on the treatment decision-making for patients with untreated glioma. Scientific Reports. ISSN 2045-2322. 9:19898, p. 1–10. doi: 10.1038/s41598-019-56333-x. Full text in Research Archive
• Seano, Giorgio; Nia, Hadi Tavakoli; Emblem, Kyrre Eeg; Datta, Meenal; Ren, Jun & Krishnan, Shanmugarajan [Show all 24 contributors for this article] (2019). Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nature Biomedical Engineering. ISSN 2157-846X. 3(3), p. 230–245. doi: 10.1038/s41551-018-0334-7.
• Latysheva, Anna; Emblem, Kyrre Eeg; Brandal, Petter; Vik-Mo, Einar O.; Pahnke, Jens & Røysland, Kjetil [Show all 8 contributors for this article] (2019). Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach. Neuroradiology. ISSN 0028-3940. 61(5), p. 545–555. doi: 10.1007/s00234-019-02173-5. Full text in Research Archive Show summary

  Purpose According to the revised World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) of 2016, oligodendrogliomas are now defined primarily by a specific molecular signature (presence of IDH mutation and 1p19q codeletion). The purpose of our study was to assess the value of dynamic susceptibility contrast MR imaging (DSC-MRI) and diffusion-weighted imaging (DWI) to characterize oligodendrogliomas and to distinguish them from astrocytomas. Methods Seventy-one adult patients with untreated WHO grade II and grade III diffuse infiltrating gliomas and known 1p/19q codeletion status were retrospectively identified and analyzed using relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) maps based on whole-tumor volume histograms. The Mann-Whitney U test and logistic regression were used to assess the ability of rCBV and ADC to differentiate between oligodendrogliomas and astrocytomas both independently, but also related to the WHO grade. Prediction performance was evaluated in leave-one-out cross-validation (LOOCV). Results Oligodendrogliomas showed significantly higher microvascularity (higher rCBVMean ≥ 0.80, p = 0.013) and higher vascular heterogeneity (lower rCBVPeak ≤ 0.044, p = 0.015) than astrocytomas. Diffuse gliomas with higher cellular density (lower ADCMean ≤ 1094 × 10−6 mm2/s, p = 0.009) were more likely to be oligodendrogliomas than astrocytomas. Histogram analysis of rCBV and ADC was able to differentiate between diffuse astrocytomas (WHO grade II) and anaplastic astrocytomas (WHO grade III). Conclusion Histogram-derived rCBV and ADC parameter may be used as biomarkers for identification of oligodendrogliomas and may help characterize diffuse gliomas based upon their genetic characteristics. Keywords Diffuse glioma Perfusion MRI Diffusion MRI

• Ina, Ly K; Vakulenko-Lagun, B; Emblem, Kyrre Eeg; Ou, Y; Da, X & Betensky, RA [Show all 15 contributors for this article] (2018). Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI. Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-34820-x.
• Angeli, Stelios; Emblem, Kyrre Eeg; Due-Tønnessen, Paulina & Stylianopoulos, Triantafyllos (2018). Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI. NeuroImage: Clinical. ISSN 2213-1582. 20, p. 664–673. doi: 10.1016/j.nicl.2018.08.032.
• Latysheva, Anna; Emblem, Kyrre Eeg; Server, Andrés; Brandal, Petter; Meling, Torstein Ragnar & Pahnke, Jens [Show all 7 contributors for this article] (2018). Survival associations using perfusion and diffusion magnetic resonance imaging in patients with histologic and genetic defined diffuse glioma World Health Organization grades II and III. Journal of computer assisted tomography. ISSN 0363-8715. 42(5), p. 807–815. doi: 10.1097/RCT.0000000000000742. Full text in Research Archive
• Digernes, Ingrid; Grøvik, Endre; Nilsen, Line; Saxhaug, Cathrine; Geier, Oliver & Reitan, Edmund [Show all 12 contributors for this article] (2018). Brain metastases with poor vascular function are susceptible to pseudoprogression after stereotactic radiation surgery. Advances in Radiation Oncology. ISSN 2452-1094. 3, p. 559–567. doi: 10.1016/j.adro.2018.05.005.
• Eide, Per Kristian; Vatnehol, Svein Are Sirirud; Emblem, Kyrre Eeg & Ringstad, Geir (2018). Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes. Scientific Reports. ISSN 2045-2322. 8(1), p. 1–10. doi: 10.1038/s41598-018-25666-4. Full text in Research Archive
• Meling, Torstein Ragnar; Latysheva, Anna; Broi, Michele Da; Jahr, Guro; Holte, Harald & Beiske, Klaus [Show all 7 contributors for this article] (2018). Is deep brain involvement in intracranial primary central nervous system lymphoma of importance for penetration of chemotherapeutic agents? Neuroradiology. ISSN 0028-3940. 60(7), p. 703–713. doi: 10.1007/s00234-018-2038-9.
• Ringstad, Geir; Valnes, Lars Magnus; Dale, Anders; Pripp, Are Hugo; Vatnehol, Svein Are Sirirud & Emblem, Kyrre Eeg [Show all 8 contributors for this article] (2018). Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. Journal of Clinical Investigation. ISSN 0021-9738. 3(13), p. 1–16. doi: 10.1172/jci.insight.121537. Full text in Research Archive
• Ringstad, Geir; Lindstrøm, Erika Kristina; Vatnehol, Svein Are Sirirud; Mardal, Kent-Andre; Emblem, Kyrre Eeg & Eide, Per Kristian (2017). Non-invasive assessment of pulsatile intracranial pressure with phase-contrast magnetic resonance imaging. PLOS ONE. ISSN 1932-6203. 12(11), p. 1–17. doi: 10.1371/journal.pone.0188896. Full text in Research Archive
• Digernes, Ingrid; Bjørnerud, Atle; Vatnehol, Svein Are Sirirud; Løvland, Grethe; Courivaud, Fredric A A & Vik-Mo, Einar O. [Show all 8 contributors for this article] (2017). A theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast MRI. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 37(6), p. 2237–2248. doi: 10.1177/0271678X17694187. Full text in Research Archive
• Kalpathy-Cramer, Jayashree; Chandra, Vinesh; Da, X; Ou, Y.; Emblem, Kyrre Eeg & Muzikansky, A [Show all 18 contributors for this article] (2016). Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma. Journal of Neuro-Oncology. ISSN 0167-594X. 131(3), p. 603–610. doi: 10.1007/s11060-016-2332-5.
• Emblem, Kyrre Eeg & Jain, Rakesh K. (2016). Improving treatment of liver metastases by targeting nonangiogenic mechanisms. Nature Medicine. ISSN 1078-8956. 22(11), p. 1209–1210. doi: 10.1038/nm.4228.
• Ringstad, Geir; Emblem, Kyrre Eeg & Eide, Per Kristian (2016). Phase-contrast magnetic resonance imaging reveals net retrograde aqueductal flow in idiopathic normal pressure hydrocephalus. Journal of Neurosurgery. ISSN 0022-3085. 124(6), p. 1850–1857. doi: 10.3171/2015.6.JNS15496.
• Heck, Ansgar; Emblem, Kyrre Eeg; Casar-Borota, Olivera; Bollerslev, Jens & Ringstad, Geir (2015). Quantitative analyses of T2-weighted MRI as a potential marker for response to somatostatin analogs in newly diagnosed acromegaly. Endocrine. ISSN 1355-008X. doi: 10.1007/s12020-015-0766-8.
• Ringstad, Geir Andre; Emblem, Kyrre Eeg; Geier, Oliver; Alperin, Noam J. & Eide, Per Kristian (2015). Aqueductal stroke volume: Comparisons with intracranial pressure scores in idiopathic normal pressure hydrocephalus. American Journal of Neuroradiology. ISSN 0195-6108. 36(9), p. 1623–1630. doi: 10.3174/ajnr.A4340.
• Juuhl-Langseth, Monica; Hartberg, Cecilie Bhandari; Holmen, Aina; Thormodsen, Rune; Groote, Inge Rasmus & Rimol, Lars Morten [Show all 9 contributors for this article] (2015). Impaired verbal learning is associated with larger caudate volumes in early onset schizophrenia spectrum disorders. PLOS ONE. ISSN 1932-6203. 10:e0130435(7). doi: 10.1371/journal.pone.0130435. Full text in Research Archive
• Gerstner, Elizabeth R.; Emblem, Kyrre Eeg & Sorensen, Gregory A. (2015). Vascular magnetic resonance imaging in brain tumors during antiangiogenic therapy - are we there yet? The Cancer Journal. ISSN 1528-9117. 21(4), p. 337–342. doi: 10.1097/PPO.0000000000000128.
• Jafari-Khouzani, Kourosh; Emblem, Kyrre Eeg; Kalpathy-Cramer, Jayashree; Bjørnerud, Atle; Vangel, Mark G. & Gerstner, Elizabeth R. [Show all 13 contributors for this article] (2015). Repeatability of cerebral perfusion using dynamic susceptibility contrast MRI in glioblastoma patients. Translational Oncology. ISSN 1944-7124. 8(3), p. 137–146. doi: 10.1016/j.tranon.2015.03.002.
• Emblem, Kyrre Eeg; Pinho, Marco C.; Zöllner, Frank G.; Due-Tønnessen, Paulina; Hald, John K & Schad, Lothar R. [Show all 9 contributors for this article] (2015). A generic support vector machine model for preoperative glioma survival associations. Radiology. ISSN 0033-8419. 275(1), p. 228–234. doi: 10.1148/radiol.14140770.
• Braband, Knut; de Lange, Charlotte; Emblem, Kyrre Eeg; Reinholt, Finn P.; Saugstad, Ola Didrik & Schram Stokke, Eirik [Show all 7 contributors for this article] (2014). Contrast-enhanced ultrasound identifies reduced overall and regional renal perfusion during global hypoxia in piglets. Investigative Radiology. ISSN 0020-9996. 49(8), p. 540–546. doi: 10.1097/RLI.0000000000000053.
• Kalpathy-Cramer, Jayashree; Gerstner, Elizabeth R.; Emblem, Kyrre Eeg; Andronesi, Ovidiu C. & Rosen, Bruce R. (2014). Advanced magnetic resonance imaging of the physical processes in human Glioblastoma. Cancer Research. ISSN 0008-5472. 74(17), p. 4622–4637. doi: 10.1158/0008-5472.CAN-14-0383.
• Emblem, Kyrre Eeg; Due-Tønnessen, Paulina; Hald, John K; Bjørnerud, Atle; Pinho, Marco C. & Scheie, David [Show all 9 contributors for this article] (2014). Machine learning in preoperative glioma MRI: Survival associations by perfusion-based support vector machine outperforms traditional MRI. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. 40(1), p. 47–54. doi: 10.1002/jmri.24390.
• Due-Tønnessen, Paulina; Groote, Inge Rasmus; Berntsen, Erik Magnus; Bjørnerud, Atle & Emblem, Kyrre Eeg (2014). Identifying the central sulcus in patients with intra-axial lesions: A multicenter study comparing conventional presurgical MRI to topographical analysis and BOLD-fMRI. Journal of computer assisted tomography. ISSN 0363-8715. 38(1), p. 1–8. doi: 10.1097/RCT.0b013e3182a589e0.
• Pinho, Marco C.; Polaskova, Pavlina; Kalpathy-Cramer, Jayashree; Jennings, Dominique; Emblem, Kyrre Eeg & Jain, Rakesh K. [Show all 11 contributors for this article] (2014). Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation. The Oncologist. ISSN 1083-7159. 19(1), p. 75–81. doi: 10.1634/theoncologist.2013-0101.
• Batchelor, Tracy T.; Gerstner, Elizabeth R.; Emblem, Kyrre E; Duda, Dan G.; Kalpathy-Cramer, Jayashree & Snuderl, Matija [Show all 23 contributors for this article] (2013). Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 110(47), p. 19059–19064. doi: 10.1073/pnas.1318022110.
• Emblem, Kyrre Eeg; Mouridsen, Kim; Bjørnerud, Atle; Farrar, Christian T.; Jennings, Dominique & Borra, Ronald J.H. [Show all 12 contributors for this article] (2013). Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy. Nature Medicine. ISSN 1078-8956. 19(9), p. 1178–1183. doi: 10.1038/nm.3289.
• Thormodsen, Rune; Rimol, Lars Morten; Tamnes, Christian Krog; Juuhl-Langseth, Monica; Holmen, Aina & Emblem, Kyrre Eeg [Show all 8 contributors for this article] (2013). Age-related cortical thickness differences in adolescents with early-onset schizophrenia compared with healthy adolescents. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 214(3), p. 190–196. doi: 10.1016/j.pscychresns.2013.07.003.
• Juuhl-Langseth, Monica; Rimol, Lars Morten; Rasmussen, Inge-André; Thormodsen, Rune; Holmen, Aina & Emblem, Kyrre Eeg [Show all 9 contributors for this article] (2012). Comprehensive segmentation of subcortical brain volumes in early onset schizophrenia reveals limited structural abnormalities. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 203(1), p. 14–23. doi: 10.1016/j.pscychresns.2011.10.005.
• Ringstad, Geir Andre; Emblem, Kyrre Eeg; Holland, Dominic; Dale, Anders M.; Bjørnerud, Atle & Hald, John K (2012). Assessment of pituitary adenoma volumetric change using longitudinal MR image registration. Neuroradiology. ISSN 0028-3940. 54(5), p. 435–443. doi: 10.1007/s00234-011-0894-7.
• Sørensen, A. Gregory; Emblem, Kyrre Eeg; Polaskova, Pavlina; Jennings, Dominique; Kim, Heisoog & Ancukiewicz, Marek [Show all 11 contributors for this article] (2012). Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion. Cancer Research. ISSN 0008-5472. 72(2), p. 402–407. doi: 10.1158/0008-5472.CAN-11-2464.
• Zöllner, Frank Gerrit; Emblem, Kyrre Eeg & Schad, Lothar R. (2012). SVM-based glioma grading: Optimization by feature reduction analysis. Zeitschrift für Medizinische Physik. ISSN 0939-3889. 22(3), p. 205–214. doi: 10.1016/j.zemedi.2012.03.007.
• Bjørnerud, Atle; Sørensen, Gregory; Mouridsen, Kim & Emblem, Kyrre Eeg (2011). T1- and T2*-dominant extravasation correction in DSC-MRI: part I--theoretical considerations and implications for assessment of tumor hemodynamic properties. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 31(10), p. 2041–2053. doi: 10.1038/jcbfm.2011.52.
• Thormodsen, Rune; Jensen, Jimmy Kristian; Holmen, Aina; Juuhl-Langseth, Monica; Emblem, Kyrre Eeg & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2011). Prefrontal hyperactivation during a working memory task in early-onset schizophrenia spectrum disorders: An fMRI study. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 194(3), p. 257–262. doi: 10.1016/j.pscychresns.2011.05.011.
• Garzon Jimenez de Cisneros, Benjamin; Emblem, Kyrre Eeg; Mouridsen, Kim; Nedregaard, Bård; Due-Tønnessen, Paulina & Nome, Terje [Show all 10 contributors for this article] (2011). Multiparametric analysis of magnetic resonance images for glioma grading and patient survival time prediction. Acta Radiologica. ISSN 0284-1851. 52(9), p. 1052–1060. doi: 10.1258/ar.2011.100510.
• Emblem, Kyrre Eeg; Bjørnerud, Atle; Mouridsen, Kim; Borra, Ronald J. H.; Batchelor, Tracy T. & Jain, Rakesh K. [Show all 7 contributors for this article] (2011). T-1- and T-2*-dominant extravasation correction in DSC-MRI: Part II-predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 31(10), p. 2054–2064. doi: 10.1038/jcbfm.2011.39.
• Lange, Eva Charlotte de; Brabrand, Knut; Emblem, Kyrre Eeg; Bjørnerud, Atle; Løberg, Else Marit & Saugstad, Ola Didrik [Show all 7 contributors for this article] (2011). Cerebral Perfusion in Perinatal Hypoxia and Resuscitation Assessed by Transcranial Contrast-Enhanced Ultrasound and 3 T MRI in Newborn Pigs. Investigative Radiology. ISSN 0020-9996. 46(11), p. 686–696. doi: 10.1097/RLI.0b013e3182266431.
• Bjørnerud, Atle; Sorensen, A. Gregory; Mouridsen, Kim & Emblem, Kyrre Eeg (2011). T-1- and T-2*-dominant extravasation correction in DSC-MRI: Part I-theoretical considerations and implications for assessment of tumor hemodynamic properties. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 31(10), p. 2041–2053. doi: 10.1038/jcbfm.2011.52.
• Zöllner, Frank Gerrit; Emblem, Kyrre Eeg & Schad, Lothar R. (2010). Support Vector Machines in DSC-Based Glioma Imaging: Suggestions for Optimal Characterization. Magnetic Resonance in Medicine. ISSN 0740-3194. 64(4), p. 1230–1236. doi: 10.1002/mrm.22495.
• Bjørnerud, Atle & Emblem, Kyrre Eeg (2010). A fully automated method for quantitative cerebral hemodynamic analysis using DSC-MRI. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 30(5), p. 1066–1078. doi: 10.1038/jcbfm.2010.4.
• Emblem, Kyrre Eeg; Nedregaard, Bård; Hald, John K; Nome, Terje; Due-Tønnessen, Paulina & Bjørnerud, Atle (2009). Automatic Glioma Characterization from Dynamic Susceptibility Contrast Imaging: Brain Tumor Segmentation Using Knowledge-Based Fuzzy Clustering. Journal of Magnetic Resonance Imaging. ISSN 1053-1807. 30(1), p. 1–10. doi: 10.1002/jmri.21815.

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• TV2, Journalist; Emblem, Kyrre E & Barua, Ishita (2023). Norske tilstander, episode 30: Kunstig intelligens og bedre helse. [TV]. TV2.
• Nordanger, Karoline; Ludvigsen, Elin; Emblem, Kyrre E & Barua, Ishita (2023). Kunstig intelligens: Kan ha svaret på vår tids største helsetrusler. [Internet]. TV2.
• Yi, Darvin; Grøvik, Endre; Tong, Elizabeth; Iv, Michael; Emblem, Kyrre E & Nilsen, Line [Show all 12 contributors for this article] (2023). Erratum to: MRI pulse sequence integration for deep-learning-based brain metastases segmentation (Medical Physics, (2021), 48, 10, (6020-6035), 10.1002/mp.15136). Medical Physics (Lancaster). ISSN 0094-2405. 50(8). doi: 10.1002/mp.16594.
• Datta, Meenal; Emblem, Kyrre Eeg & Jain, Rakesh K. (2022). Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma. bioRxiv. ISSN 2692-8205. doi: 10.1101/2022.06.28.497997.
• Lysvik, Elisabeth Kirkeby; Fuster-Garcia, Elies; Revheim, Mona-Elisabeth; Svensson, Siri Fløgstad; Ager-Wick, Gunnhild & Bugge, Robin Antony Birkeland [Show all 12 contributors for this article] (2022). Multimodal imaging of vascular and molecular biomarkers in glioblastoma.
• Due-Tønnessen, Paulina; Pinho, Marco C.; Emblem, Kyrre E; Hald, John K; Kanoto, Masafumi & Abildgaard, Andreas [Show all 10 contributors for this article] (2021). Author Correction: The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma (Scientific Reports, (2019), 9, 1, (19898), 10.1038/s41598-019-56333-x). Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-99776-x.
• Bannier, Elise; Barker, Gareth; Borghesani, Valentina; Broeckx, Nils; Clement, Patricia & Emblem, Kyrre E [Show all 36 contributors for this article] (2021). The Open Brain Consent: Informing research participants and obtaining consent to share brain imaging data. Human Brain Mapping. ISSN 1065-9471. 42(7), p. 1945–1951. doi: 10.1002/hbm.25351.
• Emblem, Kyrre Eeg (2021). Abstract 2654: Differential effect of MGMT methylation between moderate or high vascular profile in IDH wild-type glioblastoma. Cancer Research. ISSN 0008-5472. doi: 10.1158/1538-7445.AM2021-2654.
• Grøvik, Endre; Lysvik, Elisabeth Kirkeby; Bugge, Robin Antony Birkeland; Emblem, Kyrre E; Hjornevik, Trine & Vatnehol, Svein Are Sirirud [Show all 7 contributors for this article] (2021). A novel MRI phantom to study the fluid dynamics of the glymphatic system: a proof-of-concept study.
• Ly, K. Ina; Vakulenko-Lagun, Bella; Emblem, Kyrre E; Ou, Yangming; Da, Xiao & Betensky, Rebecca A. [Show all 15 contributors for this article] (2019). Publisher Correction: Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI (Scientific Reports, (2018), 8, 1, (17062), 10.1038/s41598-018-34820-x). Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-44365-2.
• Wilhelmsen, Øivind; Lohndal, Terje & Emblem, Kyrre Eeg (2018). Forskningsrådet hedrer tre store forskertalenter. [Business/trade/industry journal]. Forskningsrådet.
• Emblem, Kyrre Eeg & Bratland-Sanda, Solfrid (2018). Mangel på langsiktighet hindrer utviklingen av verdensledende forskning. Khrono.no. ISSN 1894-8995.
• Aronsen, Jan Magnus; Jensenius, Alexander Refsum; Emblem, Kyrre Eeg; Storeng, Katerini Tagmatarchi; Enberg, Katja & Knutsen, Carl Henrik [Show all 7 contributors for this article] (2017). Kvalitetsparadokset i den norske forskningspolitikken. Khrono.no. ISSN 1894-8995. Show summary

  De fleste insentivene norske forskere opplever i sin hverdag, er preget av kortsiktige resultater og målstyring mot kvantitet heller enn kvalitet. Dette er et kvalitetsparadoks i norsk forskningspolitikk. skriver flere medlemmer i Akademiet for yngre forskere.

• Andronesi, Ovidiu C.; Esmaeili, Morteza; Borra, Ronald J. H.; Emblem, Kyrre Eeg; Gerstner, Elizabeth R. & Pinho, Marco C. [Show all 17 contributors for this article] (2017). Metabolic and functional MR imaging probes early response in glioblastoma patients treated with combination antiangiogenic-chemoradiation therapy.
• Emblem, Kyrre Eeg; Enberg, Katja; Helland, Ingeborg Palm; Jensenius, Alexander Refsum; Rognes, Marie & Storeng, Katerini Tagmatarchi [Show all 7 contributors for this article] (2017). Tenk nytt om tellekanter, Haugstad! Morgenbladet. ISSN 0805-3847. Show summary

  En siteringsindikator kan være positivt for å måle forskningskvalitet fremfor -kvantitet, men vi trenger fornyelse av tellekantsystemet.

• Heck, Ansgar; Emblem, Kyrre Eeg; Casar-Borota, Olivera; Ringstad, Geir & Bollerslev, Jens (2016). MRI T2 characteristics in somatotroph adenomas following somatostatin analog treatment in acromegaly. Endocrine. ISSN 1355-008X. 53(1), p. 327–330. doi: 10.1007/s12020-015-0816-2.
• Ringstad, Geir; Eide, Per Kristian; Emblem, Kyrre Eeg; Geier, Oliver & Alperin, Noam J. (2015). Reply: To PMID 25977480. American Journal of Neuroradiology. ISSN 0195-6108. 36(9), p. 1633–1634.
• Ringstad, Geir Andre; Emblem, Kyrre Eeg; Alperin, N & Eide, Per Kristian (2013). Aqueductal stroke volume in iNPH patients: Intracranial pressure monitoring does not compare with phase-contrast MRI.
• Garzon, Benjamin J De C; Emblem, Kyrre Eeg; Mouridsen, Kim; Bjørnerud, Atle; Håberg, Asta & Kvinnsland, Yngve (2009). Multispectral Analysis of Magnetic Resonance Images for Glioma Grading.
• Thormodsen, Rune; Jensen, Jimmy Kristian; Holmen, Aina; Juuhl-Langseth, Monica; Emblem, Kyrre Eeg & Andreassen, Ole Andreas [Show all 7 contributors for this article] (2009). NEURAL CORRELATES OF WORKING MEMORY DYSFUNCTION IN EARLY ONSET SCHIZOPHRENIA: AN FMRI STUDY. Schizophrenia Bulletin. ISSN 0586-7614. 35, p. 191–192.
• deLange, Charlotte; Braband, Knut; Emblem, Kyrre Eeg; Bjørnerud, Atle; Løberg, Else Marit & Saugstad, Ola Didrik [Show all 7 contributors for this article] (2009). THE ROLE OF TRANSCRANIAL CEUS AND 3T MRI DURING AND AFTER HYPOXIA AND RESUSCITATION – AN EXPERIMENTAL STUDY IN PIGLETS. Acta Paediatrica. Supplement. ISSN 0803-5326. 98.

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